Research Laboratory - Systems and Network Biology Laboratory
Classical biological research has focused on the understanding of the function of single genes and specific biological mechanisms. With the recent development of high-throughput technologies for measuring biological data at large scale, a systems view of biology has emerged. Systems Biology investigates the behavior of an entire biological system and the relationships between its elements, with the goal of constructing global models that explain well the measured data. A succssful modeling approach views complex cellular processes as networks of interactions between molecules. The modeling and dissection of these networks presents exciting graph-theoretic and statistical problems with important applications in biology.
Within this scope, our research spans a variety of topics, including the construction and analysis of biological networks, the analysis of transcriptional regulation, and the study of genomic variation and its association with disease. It aims to both develop new analysis methods and models, and to enrich our understanding of the operation of intact biological networks and their alterations in human disorders.
The lab is supervised by Prof. Roded Sharan.