Tracking the evolution of 3D gene organization demonstrates its connection to phenotypic divergence

Alon Diament (1), Tamir Tuller (1, 2)

(1) Biomedical Engineering Dept.; Tel Aviv University; Tel Aviv, 6997801; Israel. (2) The Sagol School of Neuroscience; Tel Aviv University; Tel Aviv, 6997801; Israel.

Nucleic Acids Research, 2017. DOI:10.1093/nar/gkx205

SCOM database

For an online interactive database of annotated conserved and divergent SCOMs between the budding yeast S. cerevisiae and the fission yeast S. pombe, see the NDEx site.

SCOM scripts

The following scripts require MATLAB (for generating conservation / divergence networks from Hi-C data) and python (for detecting SCOMs in given networks, tested on python 3). The provided shell script '' demonstrates the pipeline for a small-scale example.