Translation
type: MolecularInteraction
participant: PCNA_inactive
participant: PCNA_RNA

9038370
type: PublicationXref
id: 9038370
title: PCNA: structure, functions and interactions
db: PubMed

TIPIN
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#54962
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#7398
type: UnificationXref
id: 7398
db: Entrez Gene

ATRIP
type: Protein
entity reference: ATRIP

.ATR.PROMOTES.CEP164.
type: Catalysis
controlled: Phosphorylation.P.ATR.CEP164
control type: ACTIVATION
controller: ATR
xref: 18283122
data source: Spike

16901786
type: PublicationXref
id: 16901786
title: A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response
db: PubMed

16531995
type: PublicationXref
id: 16531995
title: Regulation of monoubiquitinated PCNA by DUB autocleavage
db: PubMed

http://www.ncbi.nlm.nih.gov/#5111
type: UnificationXref
id: 5111
db: Entrez Gene

CAF-1.complex_inactive
type: Protein

NEDD4
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4734
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#8451
type: UnificationXref
id: 8451
db: Entrez Gene

CEP164_inactive
type: Protein
entity reference: CEP164

EP300
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2033
organism: Homo sapiens

CLSPN
type: Protein
entity reference: CLSPN

RNF8_inactive
type: Protein
entity reference: RNF8

SETD8
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#387893
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#1385
type: UnificationXref
id: 1385
db: Entrez Gene

10859164
type: PublicationXref
id: 10859164
title: Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
db: PubMed

10859163
type: PublicationXref
id: 10859163
title: Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice
db: PubMed

20932471
type: PublicationXref
id: 20932471
title: CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation
db: PubMed

CREB1
type: Protein
entity reference: CREB1

Translation
type: MolecularInteraction
participant: POLK_RNA
participant: POLK

http://www.ncbi.nlm.nih.gov/#7486
type: UnificationXref
id: 7486
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#9401
type: UnificationXref
id: 9401
db: Entrez Gene

RPA1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6117
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#9025
type: UnificationXref
id: 9025
db: Entrez Gene

ATRIP
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#84126
organism: Homo sapiens

16427009
type: PublicationXref
id: 16427009
title: MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals
db: PubMed

.DTL.INHIBITS.SETD8.
type: Catalysis
controlled: Ubiquitination.I.DTL.SETD8
control type: INHIBITION
controller: DTL
xref: 21220508
xref: 20932471
data source: Spike

8652557
type: PublicationXref
id: 8652557
title: Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein
db: PubMed

http://www.ncbi.nlm.nih.gov/#2033
type: UnificationXref
id: 2033
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#7874
type: UnificationXref
id: 7874
db: Entrez Gene

EP300
type: Protein
entity reference: EP300

HMGN1_inactive
type: Protein
entity reference: HMGN1

H4.family_inactive
type: Protein

WRN
type: Protein
entity reference: WRN

19680264
type: PublicationXref
id: 19680264
title: Dissecting the role of ubiquitylation in the DNA damage response checkpoint in G2
db: PubMed

Ku heterodimer (Ku-70-ku-80) XRCC6-XRCC5
type: Complex
display name: Ku heterodimer (Ku-70-ku-80).complex
data source: Spike

WRN
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7486
organism: Homo sapiens

POLK_DNA
type: DnaRegion
entity reference: POLK

CHEK2_inactive
type: Protein
entity reference: CHEK2

.ERCC5.PROMOTES.PCNA.
type: Catalysis
controlled: Physical.Interaction.P.ERCC5.PCNA
control type: ACTIVATION
controller: ERCC5
xref: 18079701
xref: 20713449
xref: 19279666
data source: Spike

17099721
type: PublicationXref
id: 17099721
title: Characterization of promoter regulatory elements involved in downexpression of the DNA polymerase kappa in colorectal cancer
db: PubMed

DDB2_inactive
type: Protein
entity reference: DDB2

CLSPN_inactive
type: Protein
entity reference: CLSPN

http://www.ncbi.nlm.nih.gov/#1069
type: UnificationXref
id: 1069
db: Entrez Gene

CHEK1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1111
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#406997
type: UnificationXref
id: 406997
db: Entrez Gene

8999876
type: PublicationXref
id: 8999876
title: Human transcription-repair coupling factor CSB/ERCC6 is a DNA-stimulated ATPase but is not a helicase and does not disrupt the ternary transcription complex of stalled RNA polymerase II
db: PubMed

http://www.ncbi.nlm.nih.gov/#84126
type: UnificationXref
id: 84126
db: Entrez Gene

FEN1
type: Protein
entity reference: FEN1

.ERCC8.PROMOTES.TCEA2.
type: Catalysis
controlled: Physical.Interaction.P.ERCC8.TCEA2
control type: ACTIVATION
controller: ERCC8
xref: 16916636
data source: Spike

H2B.family_inactive
type: Protein

CHAF1A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#10036
organism: Homo sapiens

CHAF1B
type: Protein
entity reference: CHAF1B

ATR
type: Protein
entity reference: ATR

19567405
type: PublicationXref
id: 19567405
title: Direct and indirect roles of RECQL4 in modulating base excision repair capacity
db: PubMed

DDB1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1642
organism: Homo sapiens

DDB1
type: Protein
entity reference: DDB1

RECQL4
type: Protein
entity reference: RECQL4

http://www.ncbi.nlm.nih.gov/#55832
type: UnificationXref
id: 55832
db: Entrez Gene

RPA2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6118
organism: Homo sapiens

PhysicalInteraction [MDC1 -- USP28 ]
type: MolecularInteraction
xref: 16901786
participant: USP28
participant: MDC1

10880451
type: PublicationXref
id: 10880451
title: Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair
db: PubMed

http://www.ncbi.nlm.nih.gov/#6597
type: UnificationXref
id: 6597
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#10036
type: UnificationXref
id: 10036
db: Entrez Gene

.Complex.DDB1.2.CUL4A..CUL4A,.RBX1..PROMOTES.Family.H2A...(H2AFZ).
type: Catalysis
controlled: Ubiquitination.P.DDB1.2.CUL4A.H2A
control type: ACTIVATION
controller: DDB1-DDB2-RBX1-CUL4A ubiquitine ligase E3 complex
xref: 19440044
data source: Spike

20587414
type: PublicationXref
id: 20587414
title: p300-mediated Acetylation of Histone H3 Lysine 56 Functions in DNA Damage Response in Mammals
db: PubMed

DCLRE1B
type: Protein
entity reference: DCLRE1B

http://www.ncbi.nlm.nih.gov/#2068
type: UnificationXref
id: 2068
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#2067
type: UnificationXref
id: 2067
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#7157
type: UnificationXref
id: 7157
db: Entrez Gene

19706760
type: PublicationXref
id: 19706760
title: Human papillomavirus 16 E7 oncoprotein attenuates DNA damage checkpoint control by increasing the proteolytic turnover of claspin
db: PubMed

19440044
type: PublicationXref
id: 19440044
title: ATR kinase as master regulator of nucleotide excision repair during S phase of the cell cycle
db: PubMed

TIMELESS
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8914
organism: Homo sapiens

FEN1_inactive
type: Protein
entity reference: FEN1

.RECQL4.PROMOTES.FEN1.
type: Catalysis
controlled: Physical.Interaction.P.RECQL4.FEN1
control type: ACTIVATION
controller: RECQL4
xref: 19567405
data source: Spike

7915517
type: PublicationXref
id: 7915517
title: Transcriptional regulation of the PCNA promoter by p53
db: PubMed

19270680
type: PublicationXref
id: 19270680
title: CBP/p300-mediated acetylation of histone H3 on lysine 56
db: PubMed

18079701
type: PublicationXref
id: 18079701
title: Sequential recruitment of the repair factors during NER: the role of XPG in initiating the resynthesis step
db: PubMed

CHAF1A
type: Protein
entity reference: CHAF1A

HSP70.family
type: Protein
xref: CEN:F.329896
data source: Spike

CAND1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#55832
organism: Homo sapiens

.MIR215.INHIBITS.DTL.
type: Catalysis
controlled: Translational.Regulation.I.MIR215.DTL
control type: INHIBITION
controller: MIR215
xref: 20433742
data source: Spike

ATR
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#545
organism: Homo sapiens

.ASF1B.PROMOTES.Complex.CAF.1..CHAF1A,.CHAF1B.(CHAF1B).
type: Catalysis
controlled: Physical.Interaction.P.ASF1B.CAF.1
control type: ACTIVATION
controller: ASF1B
xref: 11897662
data source: Spike

RAD23B
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5887
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#64858
type: UnificationXref
id: 64858
db: Entrez Gene

18619531
type: PublicationXref
id: 18619531
title: Identification of phosphorylation sites on transcription factor Sp1 in response to DNA damage and its accumulation at damaged sites
db: PubMed

19158375
type: PublicationXref
id: 19158375
title: Role of the tumor suppressor PTEN in antioxidant responsive element-mediated transcription and associated histone modifications
db: PubMed

17141802
type: PublicationXref
id: 17141802
title: Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors
db: PubMed

XPA_inactive
type: Protein
entity reference: XPA

http://www.ncbi.nlm.nih.gov/#2073
type: UnificationXref
id: 2073
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#2072
type: UnificationXref
id: 2072
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#2071
type: UnificationXref
id: 2071
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#11200
type: UnificationXref
id: 11200
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#57646
type: UnificationXref
id: 57646
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#2074
type: UnificationXref
id: 2074
db: Entrez Gene

POLK_RNA
type: RnaRegion
entity reference: POLK

ERCC6
type: Protein
entity reference: ERCC6

ATM
type: Protein
entity reference: ATM

CSA.complex_inactive
type: Protein

XAB2
type: Protein
entity reference: XAB2

DNA Polymerase delta tetramer [nucleoplasm]
type: Complex
display name: DNA Polymerase delta tetramer.complex
data source: Spike

.ATR.PROMOTES.SP1.
type: Catalysis
controlled: Phosphorylation.P.ATR.SP1
control type: ACTIVATION
controller: ATR
xref: 18619531
data source: Spike

TCEA2
type: Protein
entity reference: TCEA2

.XPA.PROMOTES.CEP164.
type: Catalysis
controlled: Physical.Interaction.P.XPA.CEP164
control type: ACTIVATION
controller: XPA
xref: 19197159
data source: Spike

18006705
type: PublicationXref
id: 18006705
title: Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase
db: PubMed

RNA polymerase II whole complex
type: Complex
display name: RNA polymerase II.complex
data source: Spike

17996703
type: PublicationXref
id: 17996703
title: Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1
db: PubMed

ERCC1-XPF(ERCC4).complex_inactive
type: Protein

PCNA
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5111
organism: Homo sapiens

20713449
type: PublicationXref
id: 20713449
title: Replication factor C recruits DNA polymerase delta to sites of nucleotide excision repair but is not required for PCNA recruitment
db: PubMed

19279666
type: PublicationXref
id: 19279666
title: Coordination of dual incision and repair synthesis in human nucleotide excision repair
db: PubMed

CUL4A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8451
organism: Homo sapiens

.Complex.RAD18.UBE2B....PROMOTES.PCNA.
type: Catalysis
controlled: Ubiquitination.P.RAD18.UBE2B.PCNA
control type: ACTIVATION
controller: RAD18-UBE2B UBIQUITILATION COMPLEX
xref: 20937699
xref: 10880451
xref: 19622405
data source: Spike

ASF1B
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#55723
organism: Homo sapiens

18594563
type: PublicationXref
id: 18594563
title: ATR: an essential regulator of genome integrity
db: PubMed

15279789
type: PublicationXref
id: 15279789
title: Chk1 in the DNA damage response: conserved roles from yeasts to mammals
db: PubMed

TP53_inactive
type: Protein
entity reference: TP53

19622405
type: PublicationXref
id: 19622405
title: The Fanconi anemia pathway: Insights from somatic cell genetics using DT40 cell line
db: PubMed

CLSPN
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#63967
organism: Homo sapiens

ERCC2_inactive
type: Protein
entity reference: ERCC2

Homo sapiens
type: BioSource
xref: 9606

DCLRE1B
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#64858
organism: Homo sapiens

17638878
type: PublicationXref
id: 17638878
title: Cyclin-dependent kinase 2 dependent phosphorylation of ATRIP regulates the G2-M checkpoint response to DNA damage
db: PubMed

ASF1A_inactive
type: Protein
entity reference: ASF1A

17948053
type: PublicationXref
id: 17948053
title: Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA
db: PubMed

18283122
type: PublicationXref
id: 18283122
title: Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1
db: PubMed

16360315
type: PublicationXref
id: 16360315
title: Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response
db: PubMed

PhysicalInteraction [Complex DDB1-CUL4A {CUL4A, DDB1, RBX1} -- DTL ]
type: MolecularInteraction
xref: 16949367
participant: DTL
participant: DDB1-CUL4A E3-ubiquitination complex

http://www.ncbi.nlm.nih.gov/#81620
type: UnificationXref
id: 81620
db: Entrez Gene

.ERCC8.PROMOTES.HMGN1.
type: Catalysis
controlled: Physical.Interaction.P.ERCC8.HMGN1
control type: ACTIVATION
controller: ERCC8
xref: 16916636
data source: Spike

http://www.ncbi.nlm.nih.gov/#1642
type: UnificationXref
id: 1642
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#1643
type: UnificationXref
id: 1643
db: Entrez Gene

.Complex.DDB1.CUL4A..CUL4A,.DDB1,.RBX1..PROMOTES.Family.H2A...(H2AFZ).
type: Catalysis
controlled: Ubiquitination.P.DDB1.CUL4A.H2A
control type: ACTIVATION
controller: DDB1-CUL4A E3-ubiquitination complex
xref: 16940174
data source: Spike

http://www.ncbi.nlm.nih.gov/#4734
type: UnificationXref
id: 4734
db: Entrez Gene

19197159
type: PublicationXref
id: 19197159
title: UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity
db: PubMed

http://www.ncbi.nlm.nih.gov/#8914
type: UnificationXref
id: 8914
db: Entrez Gene

ERCC1-XPF(ERCC4)
type: Complex
display name: ERCC1-XPF(ERCC4).complex
component: ERCC4
component: ERCC1
data source: Spike

11445587
type: PublicationXref
id: 11445587
title: A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH
db: PubMed

ASF1A
type: Protein
entity reference: ASF1A

http://www.ncbi.nlm.nih.gov/#5599
type: UnificationXref
id: 5599
db: Entrez Gene

CEP164
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#22897
organism: Homo sapiens

19221478
type: PublicationXref
id: 19221478
title: Cockayne syndrome B protein (CSB): linking p53, HIF-1 and p300 to robustness, lifespan, cancer and cell fate decisions
db: PubMed

http://www.ncbi.nlm.nih.gov/#9978
type: UnificationXref
id: 9978
db: Entrez Gene

.USP28.PROMOTES.CLSPN.
type: Catalysis
controlled: Deubiqitination.P.USP28.CLSPN
control type: ACTIVATION
controller: USP28
xref: 16901786
data source: Spike

.SMARCA4.PROMOTES.XPC.
type: Catalysis
controlled: Physical.Interaction.P.SMARCA4.XPC
control type: ACTIVATION
controller: SMARCA4
xref: 19740755
data source: Spike

HMGN1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3150
organism: Homo sapiens

ERCC4
type: Protein
entity reference: ERCC4

TIPIN
type: Protein
entity reference: TIPIN

PhysicalInteraction [APEX1 -- FEN1 ]
type: MolecularInteraction
xref: 16189514
xref: 11601988
participant: FEN1
participant: APEX1

ERCC6_inactive
type: Protein
entity reference: ERCC6

ERCC1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2067
organism: Homo sapiens

APEX1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#328
organism: Homo sapiens

.Complex.CAF.1..CHAF1A,.CHAF1B..PROMOTES.ASF1A.
type: Catalysis
controlled: Physical.Interaction.P.CAF.1.ASF1A
control type: ACTIVATION
controller: chromatin assembly factor 1
xref: 11897662
data source: Spike

9733515
type: PublicationXref
id: 9733515
title: Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
db: PubMed

9733514
type: PublicationXref
id: 9733514
title: Enhanced phosphorylation of p53 by ATM in response to DNA damage
db: PubMed

ATM
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#472
organism: Homo sapiens

SCF-beta-TrCP complex [cytosol]
type: Complex
display name: SCF-beta-TrCP.complex
data source: Spike

.RPA1.PROMOTES.Complex.ATR.ATRIP..ATR,.ATRIP.(ATRIP).
type: Catalysis
controlled: Physical.Interaction.P.RPA1.ATR.ATRIP
control type: ACTIVATION
controller: RPA1
xref: 15743907
data source: Spike

12574133
type: PublicationXref
id: 12574133
title: p53 is a chromatin accessibility factor for nucleotide excision repair of DNA damage
db: PubMed

HMGN1
type: Protein
entity reference: HMGN1

LIG1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3978
organism: Homo sapiens

SP1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6667
organism: Homo sapiens

16949367
type: PublicationXref
id: 16949367
title: A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1
db: PubMed

http://www.ncbi.nlm.nih.gov/#328
type: UnificationXref
id: 328
db: Entrez Gene

RBX1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#9978
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#641
type: UnificationXref
id: 641
db: Entrez Gene

RNA polymerase II.complex_inactive
type: Protein

.ERCC6.PROMOTES.MAPK8.
type: Catalysis
controlled: Other.P.ERCC6.MAPK8
control type: ACTIVATION
controller: ERCC6
xref: 16319174
data source: Spike

18451105
type: PublicationXref
id: 18451105
title: Chk1 and Claspin potentiate PCNA ubiquitination
db: PubMed

.Family.HSP70....PROMOTES.DCLRE1B.
type: Catalysis
controlled: Physical.Interaction.P.HSP70.DCLRE1B
control type: ACTIVATION
controller: HSP70.family
xref: 19411856
data source: Spike

15272308
type: PublicationXref
id: 15272308
title: Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism
db: PubMed

CHEK1
type: Protein
entity reference: CHEK1

POLH_inactive
type: Protein
entity reference: POLH

POLK
type: Protein
entity reference: POLK

TFIIH-XPC-HR23B.complex
type: Complex
component: ERCC2
component: ERCC3
component: RAD23B
data source: Spike

.Complex.COP9....INHIBITS.Complex.DDB1.2.CUL4A..CUL4A,.RBX1.(DDB1).
type: Catalysis
controlled: Deubiqitination.I.COP9.DDB1.2.CUL4A
control type: INHIBITION
controller: CSN COP9 Signalosome
xref: 12732143
data source: Spike

CHEK2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#11200
organism: Homo sapiens

ERCC2
type: Protein
entity reference: ERCC2

15163406
type: PublicationXref
id: 15163406
title: Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase
db: PubMed

.ERCC6.PROMOTES.XAB2.
type: Catalysis
controlled: Physical.Interaction.P.ERCC6.XAB2
control type: ACTIVATION
controller: ERCC6
xref: 10944529
data source: Spike

PhysicalInteraction [CHEK2 -- MDC1 ]
type: MolecularInteraction
xref: 12919958
participant: CHEK2
participant: MDC1

http://www.ncbi.nlm.nih.gov/#9656
type: UnificationXref
id: 9656
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#545
type: UnificationXref
id: 545
db: Entrez Gene

USP28
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#57646
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#6667
type: UnificationXref
id: 6667
db: Entrez Gene

ATR-ATRIP.complex_inactive
type: Protein

Cdk activating kinase [nucleoplasm]
type: Complex
display name: CAK.complex
data source: Spike

.Complex.DDB1.2.CUL4A..CUL4A,.RBX1..INHIBITS.TP53.
type: Catalysis
controlled: Ubiquitination.I.DDB1.2.CUL4A.TP53
control type: INHIBITION
controller: DDB1-DDB2-RBX1-CUL4A ubiquitine ligase E3 complex
xref: 19923893
data source: Spike

TP53
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7157
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#5429
type: UnificationXref
id: 5429
db: Entrez Gene

11985607
type: PublicationXref
id: 11985607
title: Chromatin assembly. Cooperation between histone chaperones and ATP-dependent nucleosome remodeling machines
db: PubMed

11897662
type: PublicationXref
id: 11897662
title: Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway
db: PubMed

.Complex.DDB1.CUL4A..CUL4A,.DDB1,.RBX1..PROMOTES.H2AFX.
type: Catalysis
controlled: Ubiquitination.P.DDB1.CUL4A.H2AFX
control type: ACTIVATION
controller: DDB1-CUL4A E3-ubiquitination complex
xref: 16940174
data source: Spike

18022353
type: PublicationXref
id: 18022353
title: New nomenclature for chromatin-modifying enzymes
db: PubMed

.PCNA.PROMOTES.Complex.DNA.Polymerase.delta.tetramer...(POLD4).
type: Catalysis
controlled: Physical.Interaction.P.PCNA.DNA.Polymerase.delta.tetramer
control type: ACTIVATION
controller: PCNA
xref: 9038370
data source: Spike

TFIIH [nucleoplasm]
type: Complex
display name: TFIIH.complex
component: ERCC2
component: ERCC3
data source: Spike

http://www.ncbi.nlm.nih.gov/#8208
type: UnificationXref
id: 8208
db: Entrez Gene

PCNA-RFC
type: Complex
display name: PCNA-RFC.complex
component: PCNA
data source: Spike

CUL4A_inactive
type: Protein
entity reference: CUL4A

19231300
type: PublicationXref
id: 19231300
title: Regulation of DNA damage response pathways by the cullin-RING ubiquitin ligases
db: PubMed

20112283
type: PublicationXref
id: 20112283
title: Histone modifications: crucial elements for damage response and chromatin restoration
db: PubMed

CEP164
type: Protein
entity reference: CEP164

7565690
type: PublicationXref
id: 7565690
title: An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair
db: PubMed

16319174
type: PublicationXref
id: 16319174
title: Late activation of stress kinases (SAPK/JNK) by genotoxins requires the DNA repair proteins DNA-PKcs and CSB
db: PubMed

H2B.family
type: Protein
xref: ELK:F.000027
data source: Spike

CSN COP9 Signalosome
type: Complex
display name: COP9.complex
data source: Spike

Spike
type: Provenance

20433742
type: PublicationXref
id: 20433742
title: Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells
db: PubMed

DTL_inactive
type: Protein
entity reference: DTL

http://www.ncbi.nlm.nih.gov/#6117
type: UnificationXref
id: 6117
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#6118
type: UnificationXref
id: 6118
db: Entrez Gene

APEX1_inactive
type: Protein
entity reference: APEX1

DDB1-2-CUL4A.complex_inactive
type: Protein

http://www.ncbi.nlm.nih.gov/#25842
type: UnificationXref
id: 25842
db: Entrez Gene

USP1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7398
organism: Homo sapiens

.WRN.PROMOTES.Complex.DNA.Polymerase.delta.tetramer...(POLD4).
type: Catalysis
controlled: Physical.Interaction.P.WRN.DNA.Polymerase.delta.tetramer
control type: ACTIVATION
controller: WRN
xref: 10781066
data source: Spike

H2AFX
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3014
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#7507
type: UnificationXref
id: 7507
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#7508
type: UnificationXref
id: 7508
db: Entrez Gene

15743907
type: PublicationXref
id: 15743907
title: ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation
db: PubMed

ERCC8
type: Protein
entity reference: ERCC8

.Complex.CycA.Cdk2....PROMOTES.ATRIP.
type: Catalysis
controlled: Phosphorylation.P.CycA.Cdk2.ATRIP
control type: ACTIVATION
controller: CycA-Cdk2
xref: 20932174
xref: 17638878
data source: Spike

.NEDD4.INHIBITS.Complex.RNA.polymerase.II...(POLR2L).
type: Catalysis
controlled: Ubiquitination.I.NEDD4.RNA.polymerase.II
control type: INHIBITION
controller: NEDD4
xref: 17996703
data source: Spike

ASF1B
type: Protein
entity reference: ASF1B

xeroderma pigmentosum complementation group E
type: Complex
display name: DDB1-2 (XPE).complex
component: DDB2
component: DDB1
data source: Spike

FEN1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2237
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#5887
type: UnificationXref
id: 5887
db: Entrez Gene

H3.family
type: Protein
xref: ELK:F.000028
data source: Spike

.CHEK1.PROMOTES.CLSPN.
type: Catalysis
controlled: Physical.Interaction.P.CHEK1.CLSPN
control type: ACTIVATION
controller: CHEK1
xref: 18451105
data source: Spike

CSA-CUL4A-COP9-NEDD8-ERCC8 (CSA) E3 UBIQITINE LIGASE
type: Complex
display name: CSA.complex
component: RBX1
component: CUL4A
component: DDB1
component: ERCC8
data source: Spike

PhysicalInteraction [RPA2 -- XPA ]
type: MolecularInteraction
xref: 11081631
participant: XPA
participant: RPA2

15592449
type: PublicationXref
id: 15592449
title: Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks
db: PubMed

http://www.ncbi.nlm.nih.gov/#63967
type: UnificationXref
id: 63967
db: Entrez Gene

11585903
type: PublicationXref
id: 11585903
title: Physical and functional interactions of human DNA polymerase eta with PCNA
db: PubMed

17272272
type: PublicationXref
id: 17272272
title: Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double strand breaks
db: PubMed

http://www.ncbi.nlm.nih.gov/#5347
type: UnificationXref
id: 5347
db: Entrez Gene

12356323
type: PublicationXref
id: 12356323
title: Biochemical characterization of the WRN-FEN-1 functional interaction
db: PubMed

http://www.ncbi.nlm.nih.gov/#472
type: UnificationXref
id: 472
db: Entrez Gene

15143166
type: PublicationXref
id: 15143166
title: Physical and functional interaction between the Bloom's syndrome gene product and the largest subunit of chromatin assembly factor 1
db: PubMed

DTL
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#51514
organism: Homo sapiens

chromatin assembly factor 1
type: Complex
display name: CAF-1.complex
component: CHAF1A
component: CHAF1B
data source: Spike

.TP53.PROMOTES.PCNA.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.TP53.PCNA
controller: TP53
xref: 7915517
data source: Spike

DDB2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1643
organism: Homo sapiens

SP1_inactive
type: Protein
entity reference: SP1

.PCNA.PROMOTES.Complex.CAF.1..CHAF1A,.CHAF1B.(CHAF1B).
type: Catalysis
controlled: Physical.Interaction.P.PCNA.CAF.1
control type: ACTIVATION
controller: PCNA
xref: 10648606
xref: 20112283
data source: Spike

15882621
type: PublicationXref
id: 15882621
title: UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex
db: PubMed

CUL4A
type: Protein
entity reference: CUL4A

PhysicalInteraction [CLSPN -- XPC ]
type: MolecularInteraction
xref: 17196446
participant: CLSPN
participant: XPC

.RPA1.PROMOTES.FEN1.
type: Catalysis
controlled: Physical.Interaction.P.RPA1.FEN1
control type: ACTIVATION
controller: RPA1
xref: 15592449
data source: Spike

MIR215
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#406997
organism: Homo sapiens

.H2AFX.PROMOTES.MDC1.
type: Catalysis
controlled: Physical.Interaction.P.H2AFX.MDC1
control type: ACTIVATION
controller: H2AFX
xref: 16427009
data source: Spike

.ATM.PROMOTES.CHEK2.
type: Catalysis
controlled: Phosphorylation.P.ATM.CHEK2
control type: ACTIVATION
controller: ATM
xref: 12773400
xref: 9889122
data source: Spike

12732143
type: PublicationXref
id: 12732143
title: The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage
db: PubMed

H3.family_inactive
type: Protein

RPA1
type: Protein
entity reference: RPA1

XPC_inactive
type: Protein
entity reference: XPC

PCNA_RNA
type: RnaRegion
entity reference: PCNA

XAB2_inactive
type: Protein
entity reference: XAB2

http://www.ncbi.nlm.nih.gov/#6919
type: UnificationXref
id: 6919
db: Entrez Gene

19740755
type: PublicationXref
id: 19740755
title: Modulation of nucleotide excision repair by mammalian SWI/SNF chromatin-remodeling complex
db: PubMed

21220508
type: PublicationXref
id: 21220508
title: SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation
db: PubMed

.SETD8.INHIBITS.Family.H4...(HIST2H4B).
type: Catalysis
controlled: Methylation.I.SETD8.H4
control type: INHIBITION
controller: SETD8
xref: 18022353
data source: Spike

9889122
type: PublicationXref
id: 9889122
title: A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
db: PubMed

17913884
type: PublicationXref
id: 17913884
title: The transcription elongation factor TFIIS is a component of RNA polymerase II preinitiation complexes
db: PubMed

.ERCC6.INHIBITS.TP53.
type: Catalysis
controlled: Physical.Interaction.I.ERCC6.TP53
control type: INHIBITION
controller: ERCC6
xref: 19221478
xref: 18784753
data source: Spike

TCEA2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6919
organism: Homo sapiens

MDC1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#9656
organism: Homo sapiens

PCNA_inactive
type: Protein
entity reference: PCNA

CREB1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1385
organism: Homo sapiens

USP28
type: Protein
entity reference: USP28

POLH
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5429
organism: Homo sapiens

BLM
type: Protein
entity reference: BLM

.USP7.PROMOTES.CLSPN.
type: Catalysis
controlled: Deubiqitination.P.USP7.CLSPN
control type: ACTIVATION
controller: USP7
xref: 19706760
xref: 19680264
data source: Spike

18285803
type: PublicationXref
id: 18285803
title: Regulation of DNA repair throughout the cell cycle
db: PubMed

H2A.family
type: Protein
xref: ELK:F.000026
data source: Spike

.ASF1B.PROMOTES.Family.H3...(HIST1H3F).
type: Catalysis
controlled: Physical.Interaction.P.ASF1B.H3
control type: ACTIVATION
controller: ASF1B
xref: 11985607
data source: Spike

11081631
type: PublicationXref
id: 11081631
title: Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA
db: PubMed

H2AFX_inactive
type: Protein
entity reference: H2AFX

TP53
type: Protein
entity reference: TP53

.ATR.PROMOTES.CHEK1.
type: Catalysis
controlled: Phosphorylation.P.ATR.CHEK1
control type: ACTIVATION
controller: ATR
xref: 16431910
xref: 15279789
xref: 12766152
xref: 12781359
xref: 15190204
xref: 15272308
xref: 10859164
xref: 10859163
xref: 16360315
xref: 11090622
xref: 11390642
data source: Spike

.Complex.DDB1.2.CUL4A..CUL4A,.RBX1..PROMOTES.XPC.
type: Catalysis
controlled: Ubiquitination.P.DDB1.2.CUL4A.XPC
control type: ACTIVATION
controller: DDB1-DDB2-RBX1-CUL4A ubiquitine ligase E3 complex
xref: 15882621
data source: Spike

.USP1.INHIBITS.PCNA.
type: Catalysis
controlled: Deubiqitination.I.USP1.PCNA
control type: INHIBITION
controller: USP1
xref: 16531995
data source: Spike

ERCC5
type: Protein
entity reference: ERCC5

.PLK1.INHIBITS.CLSPN.
type: Catalysis
controlled: Phosphorylation.I.PLK1.CLSPN
control type: INHIBITION
controller: PLK1
xref: 15163406
data source: Spike

http://www.ncbi.nlm.nih.gov/#22897
type: UnificationXref
id: 22897
db: Entrez Gene

USP7
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7874
organism: Homo sapiens

.EP300.PROMOTES.Family.H3...(HIST1H3F).
type: Catalysis
controlled: Acetylation.P.EP300.H3
control type: ACTIVATION
controller: EP300
xref: 19158375
xref: 19270680
xref: 20587414
data source: Spike

10781066
type: PublicationXref
id: 10781066
title: Functional interaction between the Werner Syndrome protein and DNA polymerase delta
db: PubMed

ELK:F.000026
type: UnificationXref
id: ELK:F-000026
db: Spike DB

RAD18-UBE2B UBIQUITILATION COMPLEX
type: Complex
display name: RAD18-UBE2B.complex
data source: Spike

ELK:F.000028
type: UnificationXref
id: ELK:F-000028
db: Spike DB

ELK:F.000027
type: UnificationXref
id: ELK:F-000027
db: Spike DB

ELK:F.000029
type: UnificationXref
id: ELK:F-000029
db: Spike DB

USP1
type: Protein
entity reference: USP1

http://www.ncbi.nlm.nih.gov/#54962
type: UnificationXref
id: 54962
db: Entrez Gene

.Complex.CAK....INHIBITS.ERCC2.
type: Catalysis
controlled: Physical.Interaction.I.CAK.ERCC2
control type: INHIBITION
controller: Cdk activating kinase [nucleoplasm]
xref: 11445587
data source: Spike

POLK
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#51426
organism: Homo sapiens

16916636
type: PublicationXref
id: 16916636
title: Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo
db: PubMed

.MDC1.PROMOTES.ATM.
type: Catalysis
controlled: Physical.Interaction.P.MDC1.ATM
control type: ACTIVATION
controller: MDC1
xref: 16427009
data source: Spike

ASF1A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#25842
organism: Homo sapiens

.TP53.PROMOTES.EP300.
type: Catalysis
controlled: Physical.Interaction.P.TP53.EP300
control type: ACTIVATION
controller: TP53
xref: 12574133
data source: Spike

APEX1
type: Protein
entity reference: APEX1

SMARCA4
type: Protein
entity reference: SMARCA4

http://www.ncbi.nlm.nih.gov/#2237
type: UnificationXref
id: 2237
db: Entrez Gene

.Complex.SCF.beta.TrCP....INHIBITS.CLSPN.
type: Catalysis
controlled: Ubiquitination.I.SCF.beta.TrCP.CLSPN
control type: INHIBITION
controller: SCF-beta-TrCP complex [cytosol]
xref: 18285803
data source: Spike

PhysicalInteraction [CLSPN -- DDB2 ]
type: MolecularInteraction
xref: 17196446
participant: CLSPN
participant: DDB2

.CREB1.PROMOTES.POLK.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.CREB1.POLK
controller: CREB1
xref: 17099721
data source: Spike

16940174
type: PublicationXref
id: 16940174
title: DDB1 maintains genome integrity through regulation of Cdt1
db: PubMed

H1.family
type: Protein
xref: CEN:F.329895
data source: Spike

H2A.family_inactive
type: Protein

LIG3-XRCC1
type: Complex
display name: LIG3-XRCC1.complex
data source: Spike

16713569
type: PublicationXref
id: 16713569
title: A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
db: PubMed

CETN2
type: Protein
entity reference: CETN2

11390642
type: PublicationXref
id: 11390642
title: ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
db: PubMed

http://www.ncbi.nlm.nih.gov/#51426
type: UnificationXref
id: 51426
db: Entrez Gene

19586908
type: PublicationXref
id: 19586908
title: Checkpoint kinase ATR promotes nucleotide excision repair of UV-induced DNA damage via physical interaction with xeroderma pigmentosum group A
db: PubMed

PhysicalInteraction [RPA1 -- Complex TIMELESS-TIPIN {TIMELESS, TIPIN} ]
type: MolecularInteraction
xref: 17141802
participant: TIMELESS-TIPIN
participant: RPA1

CETN2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1069
organism: Homo sapiens

MAPK8
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5599
organism: Homo sapiens

ASF1B_inactive
type: Protein
entity reference: ASF1B

DNA Polymerase delta tetramer.complex_inactive
type: Protein

XPC-HARD23B
type: Complex
display name: XPC-HRAD23B.complex
component: CETN2
component: RAD23B
component: XPC
data source: Spike

.ATR.PROMOTES.ATM.
type: Catalysis
controlled: Phosphorylation.P.ATR.ATM
control type: ACTIVATION
controller: ATR
xref: 17124492
data source: Spike

http://www.ncbi.nlm.nih.gov/#51514
type: UnificationXref
id: 51514
db: Entrez Gene

20937699
type: PublicationXref
id: 20937699
title: RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network
db: PubMed

ERCC3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2071
organism: Homo sapiens

12773400
type: PublicationXref
id: 12773400
title: A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein
db: PubMed

MAPK8_inactive
type: Protein
entity reference: MAPK8

POLH
type: Protein
entity reference: POLH

12919958
type: PublicationXref
id: 12919958
title: ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses
db: PubMed

.ASF1A.PROMOTES.Family.H3...(HIST1H3F).
type: Catalysis
controlled: Physical.Interaction.P.ASF1A.H3
control type: ACTIVATION
controller: ASF1A
xref: 11985607
data source: Spike

.ERCC8.PROMOTES.XPA.
type: Catalysis
controlled: Physical.Interaction.P.ERCC8.XPA
control type: ACTIVATION
controller: ERCC8
xref: 8999876
data source: Spike

16326861
type: PublicationXref
id: 16326861
title: The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA
db: PubMed

USP7
type: Protein
entity reference: USP7

PhysicalInteraction [Family H1 {} -- HMGN1 ]
type: MolecularInteraction
xref: 4022776
participant: H1.family
participant: HMGN1

.RNF8.PROMOTES.Family.H2A...(H2AFZ).
type: Catalysis
controlled: Ubiquitination.P.RNF8.H2A
control type: ACTIVATION
controller: RNF8
xref: 18001824
xref: 19797077
data source: Spike

ERCC2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2068
organism: Homo sapiens

.ASF1B.PROMOTES.Family.H4...(HIST2H4B).
type: Catalysis
controlled: Physical.Interaction.P.ASF1B.H4
control type: ACTIVATION
controller: ASF1B
xref: 11985607
data source: Spike

SP1
type: Protein
entity reference: SP1

DNA polymerase epsilon [nucleoplasm]
type: Complex
display name: DNA polymerase epsilon.complex
data source: Spike

NEDD4
type: Protein
entity reference: NEDD4

.CAND1.INHIBITS.CUL4A.
type: Catalysis
controlled: Physical.Interaction.I.CAND1.CUL4A
control type: INHIBITION
controller: CAND1
xref: 19231300
data source: Spike

RECQL4
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#9401
organism: Homo sapiens

XPA
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7507
organism: Homo sapiens

PLK1
type: Protein
entity reference: PLK1

RAD23B
type: Protein
entity reference: RAD23B

20368362
type: PublicationXref
id: 20368362
title: DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku and contributes to the recruitment of XPA
db: PubMed

17124492
type: PublicationXref
id: 17124492
title: ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling
db: PubMed

MIR215
type: Protein
entity reference: MIR215

XPC
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7508
organism: Homo sapiens

.XPC.PROMOTES.Complex.DDB1.2.CUL4A..CUL4A,.RBX1.(DDB1).
type: Catalysis
controlled: Physical.Interaction.P.XPC.DDB1.2.CUL4A
control type: ACTIVATION
controller: XPC
xref: 20368362
data source: Spike

ATM_inactive
type: Protein
entity reference: ATM

XAB2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#56949
organism: Homo sapiens

.Complex.CAF.1..CHAF1A,.CHAF1B..PROMOTES.ASF1B.
type: Catalysis
controlled: Physical.Interaction.P.CAF.1.ASF1B
control type: ACTIVATION
controller: chromatin assembly factor 1
xref: 11897662
data source: Spike

.ERCC8.PROMOTES.XAB2.
type: Catalysis
controlled: Physical.Interaction.P.ERCC8.XAB2
control type: ACTIVATION
controller: ERCC8
xref: 10944529
data source: Spike

19329487
type: PublicationXref
id: 19329487
title: A UV-sensitive syndrome patient with a specific CSA mutation reveals separable roles for CSA in response to UV and oxidative DNA damage
db: PubMed

TIMELESS
type: Protein
entity reference: TIMELESS

.Complex.Ku.heterodimer.(Ku.70.ku.80)....INHIBITS.Complex.DDB1.2.CUL4A..CUL4A,.RBX1.(DDB1).
type: Catalysis
controlled: Other.I.Ku.heterodimer.(Ku.70.ku.80).DDB1.2.CUL4A
control type: INHIBITION
controller: Ku heterodimer (Ku-70-ku-80) XRCC6-XRCC5
xref: 20368362
data source: Spike

PLK1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5347
organism: Homo sapiens

.ATR.PROMOTES.H2AFX.
type: Catalysis
controlled: Phosphorylation.P.ATR.H2AFX
control type: ACTIVATION
controller: ATR
xref: 12919958
data source: Spike

.Complex.COP9....INHIBITS.Complex.CSA..ERCC8,.CUL4A,.DDB1,.RBX1.(ERCC8).
type: Catalysis
controlled: Deubiqitination.I.COP9.CSA
control type: INHIBITION
controller: CSN COP9 Signalosome
xref: 12732143
data source: Spike

BLM
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#641
organism: Homo sapiens

4022776
type: PublicationXref
id: 4022776
title: Histone H1 and HMG 14/17 are deposited nonrandomly in the nucleus
db: PubMed

16431910
type: PublicationXref
id: 16431910
title: Rapid activation of ATR by ionizing radiation requires ATM and Mre11
db: PubMed

TIMELESS-TIPIN
type: Complex
display name: TIMELESS-TIPIN.complex
component: TIPIN
component: TIMELESS
data source: Spike

15190204
type: PublicationXref
id: 15190204
title: ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage
db: PubMed

DCLRE1B_inactive
type: Protein
entity reference: DCLRE1B

CAND1
type: Protein
entity reference: CAND1

ERCC8
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1161
organism: Homo sapiens

CHEK1_inactive
type: Protein
entity reference: CHEK1

http://www.ncbi.nlm.nih.gov/#1111
type: UnificationXref
id: 1111
db: Entrez Gene

11090622
type: PublicationXref
id: 11090622
title: Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts
db: PubMed

RNF8
type: Protein
entity reference: RNF8

MDC1
type: Protein
entity reference: MDC1

MDC1_inactive
type: Protein
entity reference: MDC1

CDT1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#81620
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#3150
type: UnificationXref
id: 3150
db: Entrez Gene

10648606
type: PublicationXref
id: 10648606
title: A CAF-1-PCNA-mediated chromatin assembly pathway triggered by sensing DNA damage
db: PubMed

9606
type: UnificationXref
id: 9606
db: taxonomy

.SP1.PROMOTES.POLK.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.SP1.POLK
controller: SP1
xref: 17099721
data source: Spike

DTL
type: Protein
entity reference: DTL

19411856
type: PublicationXref
id: 19411856
title: Evidence for hSNM1B/Apollo functioning in the HSP70 mediated DNA damage response
db: PubMed

18001824
type: PublicationXref
id: 18001824
title: RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
db: PubMed

.Complex.DDB1.CUL4A..CUL4A,.DDB1,.RBX1..INHIBITS.CDT1.
type: Catalysis
controlled: Ubiquitination.I.DDB1.CUL4A.CDT1
control type: INHIBITION
controller: DDB1-CUL4A E3-ubiquitination complex
xref: 16940174
data source: Spike

DDB2
type: Protein
entity reference: DDB2

9843217
type: PublicationXref
id: 9843217
title: ATM associates with and phosphorylates p53: mapping the region of interaction
db: PubMed

RPA2
type: Protein
entity reference: RPA2

http://www.ncbi.nlm.nih.gov/#3978
type: UnificationXref
id: 3978
db: Entrez Gene

CycA-Cdk2
type: Complex
display name: CycA-Cdk2.complex
data source: Spike

XPA
type: Protein
entity reference: XPA

ATR-ATRIP [nucleoplasm]
type: Complex
display name: ATR-ATRIP.complex
component: ATR
component: ATRIP
data source: Spike

16611994
type: PublicationXref
id: 16611994
title: Rad18 regulates DNA polymerase kappa and is required for recovery from S-phase checkpoint-mediated arrest
db: PubMed

.ATR.PROMOTES.TP53.
type: Catalysis
controlled: Phosphorylation.P.ATR.TP53
control type: ACTIVATION
controller: ATR
xref: 9733515
xref: 9733514
xref: 17272272
xref: 9843217
data source: Spike

SETD8_inactive
type: Protein
entity reference: SETD8

PCNA_DNA
type: DnaRegion
entity reference: PCNA

PhysicalInteraction [RPA1 -- XPA ]
type: MolecularInteraction
xref: 7565690
participant: RPA1
participant: XPA

Replication Protein A
type: Complex
display name: RPA.complex
component: RPA1
component: RPA2
data source: Spike

.RECQL4.PROMOTES.APEX1.
type: Catalysis
controlled: mRNA.stability.P.RECQL4.APEX1
control type: ACTIVATION
controller: RECQL4
xref: 19567405
data source: Spike

CDT1_inactive
type: Protein
entity reference: CDT1

.ATR.UNKNOWN.MDC1.
type: Catalysis
controlled: Phosphorylation.U.ATR.MDC1
control type: ACTIVATION_UNKMECH
controller: ATR
xref: 18077418
data source: Spike

SMARCA4
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6597
organism: Homo sapiens

SWI/SNF
type: Complex
display name: SWI/SNF.complex
component: SMARCA4
data source: Spike

20932174
type: PublicationXref
id: 20932174
title: Cyclin-dependent kinases (cdks) and the DNA damage response: rationale for cdk inhibitor-chemotherapy combinations as an anticancer strategy for solid tumors
db: PubMed

RBX1
type: Protein
entity reference: RBX1

ERCC4
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2072
organism: Homo sapiens

.ASF1A.PROMOTES.Family.H4...(HIST2H4B).
type: Catalysis
controlled: Physical.Interaction.P.ASF1A.H4
control type: ACTIVATION
controller: ASF1A
xref: 11985607
data source: Spike

16189514
type: PublicationXref
id: 16189514
title: Towards a proteome-scale map of the human protein-protein interaction network
db: PubMed

.MDC1.PROMOTES.RNF8.
type: Catalysis
controlled: Indirect.P.MDC1.RNF8
control type: ACTIVATION
controller: MDC1
xref: 18001824
data source: Spike

http://www.ncbi.nlm.nih.gov/#55723
type: UnificationXref
id: 55723
db: Entrez Gene

CEN:F.329895
type: UnificationXref
id: CEN:F-329895
db: Spike DB

ERCC6
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2074
organism: Homo sapiens

CEN:F.329896
type: UnificationXref
id: CEN:F-329896
db: Spike DB

.XPA.PROMOTES.Complex.ERCC1.XPF(ERCC4)..ERCC1,.ERCC4.(ERCC1).
type: Catalysis
controlled: Physical.Interaction.P.XPA.ERCC1.XPF(ERCC4)
control type: ACTIVATION
controller: XPA
xref: 17948053
data source: Spike

.ASF1A.PROMOTES.Complex.CAF.1..CHAF1A,.CHAF1B.(CHAF1B).
type: Catalysis
controlled: Physical.Interaction.P.ASF1A.CAF.1
control type: ACTIVATION
controller: ASF1A
xref: 11897662
data source: Spike

RNF8
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#9025
organism: Homo sapiens

MAPK8
type: Protein
entity reference: MAPK8

.Complex.CSA..ERCC8,.CUL4A,.DDB1,.RBX1..INHIBITS.ERCC6.
type: Catalysis
controlled: Ubiquitination.I.CSA.ERCC6
control type: INHIBITION
controller: CSA-CUL4A-COP9-NEDD8-ERCC8 (CSA) E3 UBIQITINE LIGASE
xref: 19329487
data source: Spike

18077418
type: PublicationXref
id: 18077418
title: Profiling of UV-induced ATM/ATR signaling pathways
db: PubMed

SETD8
type: Protein
entity reference: SETD8

PhysicalInteraction [XAB2 -- XPA ]
type: MolecularInteraction
xref: 10944529
participant: XPA
participant: XAB2

PCNA
type: Protein
entity reference: PCNA

http://www.ncbi.nlm.nih.gov/#3014
type: UnificationXref
id: 3014
db: Entrez Gene

ERCC1
type: Protein
entity reference: ERCC1

PhysicalInteraction [ERCC5 -- ERCC6 ]
type: MolecularInteraction
xref: 8652557
xref: 16713569
participant: ERCC6
participant: ERCC5

12781359
type: PublicationXref
id: 12781359
title: Chk1 and Chk2 kinases in checkpoint control and cancer
db: PubMed

CDT1
type: Protein
entity reference: CDT1

10944529
type: PublicationXref
id: 10944529
title: XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription
db: PubMed

DDB1-DDB2-RBX1-CUL4A ubiquitine ligase E3 complex
type: Complex
display name: DDB1-2-CUL4A.complex
component: RBX1
component: CUL4A
data source: Spike

11601988
type: PublicationXref
id: 11601988
title: Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair
db: PubMed

http://www.ncbi.nlm.nih.gov/#1161
type: UnificationXref
id: 1161
db: Entrez Gene

ERCC5
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2073
organism: Homo sapiens

H2AFX
type: Protein
entity reference: H2AFX

.CHEK2.INHIBITS.ASF1A.
type: Catalysis
controlled: Physical.Interaction.I.CHEK2.ASF1A
control type: INHIBITION
controller: CHEK2
xref: 11985607
data source: Spike

PhysicalInteraction [MDC1 -- RNF8 ]
type: MolecularInteraction
xref: 18006705
xref: 18001824
participant: RNF8
participant: MDC1

.BLM.PROMOTES.FEN1.
type: Catalysis
controlled: Physical.Interaction.P.BLM.FEN1
control type: ACTIVATION
controller: BLM
xref: 12356323
xref: 16326861
data source: Spike

H4.family
type: Protein
xref: ELK:F.000029
data source: Spike

.RNF8.PROMOTES.Family.H2B...(HIST1H2BJ).
type: Catalysis
controlled: Ubiquitination.P.RNF8.H2B
control type: ACTIVATION
controller: RNF8
xref: 19015238
data source: Spike

LIG1
type: Protein
entity reference: LIG1

18784753
type: PublicationXref
id: 18784753
title: CSB protein is (a direct target of HIF-1 and) a critical mediator of the hypoxic response
db: PubMed

ATRIP_inactive
type: Protein
entity reference: ATRIP

17196446
type: PublicationXref
id: 17196446
title: Role of Claspin in regulation of nucleotide excision repair factor DDB2
db: PubMed

19015238
type: PublicationXref
id: 19015238
title: Histone ubiquitination associates with BRCA1-dependent DNA damage response
db: PubMed

EP300_inactive
type: Protein
entity reference: EP300

.BLM.PROMOTES.Complex.CAF.1..CHAF1A,.CHAF1B.(CHAF1A).
type: Catalysis
controlled: Physical.Interaction.P.BLM.CAF.1
control type: ACTIVATION
controller: BLM
xref: 15143166
data source: Spike

PhysicalInteraction [Complex RNA polymerase II {} -- TCEA2 ]
type: MolecularInteraction
xref: 17913884
participant: TCEA2
participant: RNA polymerase II whole complex

CHAF1B
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8208
organism: Homo sapiens

19923893
type: PublicationXref
id: 19923893
title: DDB2 (damaged-DNA binding protein 2) in nucleotide excision repair and DNA damage response
db: PubMed

PhysicalInteraction [PCNA -- POLK ]
type: MolecularInteraction
xref: 16611994
participant: PCNA
participant: POLK

http://www.ncbi.nlm.nih.gov/#387893
type: UnificationXref
id: 387893
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#56949
type: UnificationXref
id: 56949
db: Entrez Gene

CHEK2
type: Protein
entity reference: CHEK2

.Complex.DDB1.2.CUL4A..CUL4A,.RBX1..INHIBITS.DDB2.
type: Catalysis
controlled: Ubiquitination.I.DDB1.2.CUL4A.DDB2
control type: INHIBITION
controller: DDB1-DDB2-RBX1-CUL4A ubiquitine ligase E3 complex
xref: 19231300
data source: Spike

PhysicalInteraction [Complex RNA polymerase II {} -- XAB2 ]
type: MolecularInteraction
xref: 10944529
participant: RNA polymerase II whole complex
participant: XAB2

DDB1-CUL4A E3-ubiquitination complex
type: Complex
display name: DDB1-CUL4A.complex
component: RBX1
component: CUL4A
component: DDB1
data source: Spike

ERCC3
type: Protein
entity reference: ERCC3

12766152
type: PublicationXref
id: 12766152
title: Human claspin is required for replication checkpoint control
db: PubMed

TCEA2_inactive
type: Protein
entity reference: TCEA2

.ATR.PROMOTES.XPA.
type: Catalysis
controlled: Phosphorylation.P.ATR.XPA
control type: ACTIVATION
controller: ATR
xref: 19586908
xref: 18594563
data source: Spike

19797077
type: PublicationXref
id: 19797077
title: Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response
db: PubMed

.Complex.PCNA.RFC..PCNA..PROMOTES.POLH.
type: Catalysis
controlled: Physical.Interaction.P.PCNA.RFC.POLH
control type: ACTIVATION
controller: PCNA-RFC
xref: 11585903
data source: Spike

XPC
type: Protein
entity reference: XPC