PCNA: structure, functions and interactions
A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response
Regulation of monoubiquitinated PCNA by DUB autocleavage
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice
CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals
Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein
Dissecting the role of ubiquitylation in the DNA damage response checkpoint in G2
Ku heterodimer (Ku-70-ku-80) XRCC6-XRCC5
Characterization of promoter regulatory elements involved in downexpression of the DNA polymerase kappa in colorectal cancer
Human transcription-repair coupling factor CSB/ERCC6 is a DNA-stimulated ATPase but is not a helicase and does not disrupt the ternary transcription complex of stalled RNA polymerase II
Direct and indirect roles of RECQL4 in modulating base excision repair capacity
Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair
p300-mediated Acetylation of Histone H3 Lysine 56 Functions in DNA Damage Response in Mammals
Human papillomavirus 16 E7 oncoprotein attenuates DNA damage checkpoint control by increasing the proteolytic turnover of claspin
ATR kinase as master regulator of nucleotide excision repair during S phase of the cell cycle
Transcriptional regulation of the PCNA promoter by p53
CBP/p300-mediated acetylation of histone H3 on lysine 56
Sequential recruitment of the repair factors during NER: the role of XPG in initiating the resynthesis step
Identification of phosphorylation sites on transcription factor Sp1 in response to DNA damage and its accumulation at damaged sites
Role of the tumor suppressor PTEN in antioxidant responsive element-mediated transcription and associated histone modifications
Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors
DNA Polymerase delta tetramer [nucleoplasm]
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase
Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1
Replication factor C recruits DNA polymerase delta to sites of nucleotide excision repair but is not required for PCNA recruitment
Coordination of dual incision and repair synthesis in human nucleotide excision repair
ATR: an essential regulator of genome integrity
Chk1 in the DNA damage response: conserved roles from yeasts to mammals
The Fanconi anemia pathway: Insights from somatic cell genetics using DT40 cell line
Cyclin-dependent kinase 2 dependent phosphorylation of ATRIP regulates the G2-M checkpoint response to DNA damage
Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA
Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1
Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response
PhysicalInteraction [Complex DDB1-CUL4A {CUL4A, DDB1, RBX1} -- DTL ]
UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity
A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH
Cockayne syndrome B protein (CSB): linking p53, HIF-1 and p300 to robustness, lifespan, cancer and cell fate decisions
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
Enhanced phosphorylation of p53 by ATM in response to DNA damage
p53 is a chromatin accessibility factor for nucleotide excision repair of DNA damage
A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1
Chk1 and Claspin potentiate PCNA ubiquitination
Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism
Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase
Chromatin assembly. Cooperation between histone chaperones and ATP-dependent nucleosome remodeling machines
Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway
New nomenclature for chromatin-modifying enzymes
Regulation of DNA damage response pathways by the cullin-RING ubiquitin ligases
Histone modifications: crucial elements for damage response and chromatin restoration
An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair
Late activation of stress kinases (SAPK/JNK) by genotoxins requires the DNA repair proteins DNA-PKcs and CSB
Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells
ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation
xeroderma pigmentosum complementation group E
CSA-CUL4A-COP9-NEDD8-ERCC8 (CSA) E3 UBIQITINE LIGASE
Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks
Physical and functional interactions of human DNA polymerase eta with PCNA
Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double strand breaks
Biochemical characterization of the WRN-FEN-1 functional interaction
Physical and functional interaction between the Bloom's syndrome gene product and the largest subunit of chromatin assembly factor 1
UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex
The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage
Modulation of nucleotide excision repair by mammalian SWI/SNF chromatin-remodeling complex
SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
The transcription elongation factor TFIIS is a component of RNA polymerase II preinitiation complexes
Regulation of DNA repair throughout the cell cycle
Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA
Functional interaction between the Werner Syndrome protein and DNA polymerase delta
Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo
DDB1 maintains genome integrity through regulation of Cdt1
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
Checkpoint kinase ATR promotes nucleotide excision repair of UV-induced DNA damage via physical interaction with xeroderma pigmentosum group A
PhysicalInteraction [RPA1 -- Complex TIMELESS-TIPIN {TIMELESS, TIPIN} ]
DNA Polymerase delta tetramer.complex_inactive
RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network
A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein
ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses
The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA
PhysicalInteraction [Family H1 {} -- HMGN1 ]
DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku and contributes to the recruitment of XPA
ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling
A UV-sensitive syndrome patient with a specific CSA mutation reveals separable roles for CSA in response to UV and oxidative DNA damage
Histone H1 and HMG 14/17 are deposited nonrandomly in the nucleus
Rapid activation of ATR by ionizing radiation requires ATM and Mre11
ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage
Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts
A CAF-1-PCNA-mediated chromatin assembly pathway triggered by sensing DNA damage
Evidence for hSNM1B/Apollo functioning in the HSP70 mediated DNA damage response
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
ATM associates with and phosphorylates p53: mapping the region of interaction
Rad18 regulates DNA polymerase kappa and is required for recovery from S-phase checkpoint-mediated arrest
Cyclin-dependent kinases (cdks) and the DNA damage response: rationale for cdk inhibitor-chemotherapy combinations as an anticancer strategy for solid tumors
Towards a proteome-scale map of the human protein-protein interaction network
Profiling of UV-induced ATM/ATR signaling pathways
Chk1 and Chk2 kinases in checkpoint control and cancer
XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription
DDB1-DDB2-RBX1-CUL4A ubiquitine ligase E3 complex
Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair
CSB protein is (a direct target of HIF-1 and) a critical mediator of the hypoxic response
Role of Claspin in regulation of nucleotide excision repair factor DDB2
Histone ubiquitination associates with BRCA1-dependent DNA damage response
PhysicalInteraction [Complex RNA polymerase II {} -- TCEA2 ]
DDB2 (damaged-DNA binding protein 2) in nucleotide excision repair and DNA damage response
PhysicalInteraction [Complex RNA polymerase II {} -- XAB2 ]
Human claspin is required for replication checkpoint control
Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response