Computational Systems Biology, Spring 2011
0368-4158

 

Instructors: Martin Kupiec, Eytan Ruppin and Roded Sharan

Office hours: by appointment.


Syllabus and Handouts

Following is a tentative outline of the course, which will be updated according to what is actually studied in class:

Week

Date

Lecture & handouts

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1

21 Feb

Introduction to Molecular & Systems Biology (I)

 

2

28 Feb

Introduction to Molecular & Systems Biology (II)

 

3

7 Mar

Calssification, Clustering & Biclustering

 

4

14 Mar

Transcriptional regulation: promoter sequence analysis

Tanay et al. PNAS04 (SAMBA)

5

21 Mar

Discussion on the power of gene expression analysis (emphasis on the SAMBA paper)

 

6

28 Mar

Tirgul: construction and analysis of biclusters

Kelley et al. NBT05

7

4 Apr

Genetic and protein-protein interactions (discussion on the Kelley et al. paper)

 

8

11 Apr

Network analysis

 

9

2 May

Metabolism I: introduction

 

10

16 May

Metabolism II: modeling

 

11

23 May

Metabolism III: disease modeling

 

12

30 May

Guest lecture

 

13

Jun 6

Metabolism IV

 

 


Bibliography and Notes

A recommended book on introduction to biology is 'Molecular Biology of the Cell' by Alberts et al.