PubMed
12430714
Autocrine signaling through Ras regulates cell survival activity in human glioma cells: potential cross-talk between Ras and the phosphatidylinositol 3-kinase-Akt pathway
PubMed
21070974
Phosphoinositides are essential coactivators for p21-activated kinase 1
CDKN1A
PubMed
9148935
Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src
INHIBITION
PubMed
20478380
RalGDS family members couple Ras to Ral signalling and that's not all
Spike DB
WEB:0003687
PAK1
PubMed
1381507
Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product
ACTIVATION
PubMed
10438924
The B cell antigen receptor activates the Akt (protein kinase B)/glycogen synthase kinase-3 signaling pathway via phosphatidylinositol 3-kinase
HGF
IGF2R_inactive
PubMed
8107774
A brain serine/threonine protein kinase activated by Cdc42 and Rac1
PubMed
11099047
Deacetylation of p53 modulates its effect on cell growth and apoptosis
IGF1
Entrez Gene
83593
KRAS_inactive
Entrez Gene
51196
PLCE1_inactive
Entrez Gene
7074
PubMed
9381178
Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
ACTIVATION
PAK1_inactive
CTNNB1
PubMed
12791979
Wnt signaling, Ca2+, and cyclic GMP: visualizing Frizzled functions
CCND1
CDH1
PDGF.family
EGFR
PubMed
16540633
The phosphoinositide 3-kinase/Akt1/Par-4 axis: a cancer-selective therapeutic target
PubMed
17160011
Modulation of protein kinase C by curcumin; inhibition and activation switched by calcium ions
Entrez Gene
3815
Entrez Gene
1499
KIT
CTNNB1
PubMed
22110359
Characterization of the Rho GTPase-Activating Protein RhoGAP68F
PhysicalInteraction [RASSF1 -- RASSF5 ]
PubMed
19597465
Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesis
HDAC1_inactive
PhysicalInteraction [PTK2 -- PXN ]
ACTIVATION
Actin.family
Entrez Gene
2064
Entrez Gene
2065
ACTIVATION
PLD1
CTTN
EGFR_inactive
FLT3
Entrez Gene
3845
AP-1 (JUN/:FOS)
AP-1_I.complex
RALGDS
INHIBITION
PIP3_inactive
ACTIVATION
PIP3
RALB
Spike DB
WEB:0002987
PubMed
19931527
Recent developments in our understanding of how platelet-derived growth factor (PDGF) and its receptors contribute to proliferative vitreoretinopathy
ACTIVATION
Entrez Gene
7039
PLD1
PubMed
20940393
Phosphorylation of RalB is important for bladder cancer cell growth and metastasis
KITLG
TIAM1_inactive
PubMed
9252186
A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB
RAF1
Entrez Gene
673
EGF
TP53_inactive
PubMed
22119715
TGF- Promotes Proliferation of Thyroid Epithelial Cells in IFN-(-/-) Mice by Down-Regulation of p21 and p27 via AKT Pathway
MTOR
INHIBITION
FOS
ACTIVATION
INHIBITION
Entrez Gene
4914
INHIBITION
ROCK1/2.family
ERK1/2.family
MAP3K4
PubMed
16317285
Molecular targeting of growth factor receptor-bound 2 (Grb2) as an anti-cancer strategy
Entrez Gene
5058
PubMed
15169778
Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation
Entrez Gene
207
IGF2R
PubMed
15725726
Overview of cell death signaling pathways
ACTIVATION
PLCE1
PubMed
11022048
Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras
ACTIVATION
PubMed
11130063
Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1
PubMed
9854310
ECM signalling: orchestrating cell behaviour and misbehaviour
PTK2
PA_inactive
GAB1
ATM
Entrez Gene
842
PDPK1
RALA
AP-1_I.complex_DNA
PubMed
19962312
ATM Regulates a RASSF1A-Dependent DNA Damage Response
Entrez Gene
7414
ACTIVATION
PRKC.family
PubMed
14993273
Inhibition of the Jun N-terminal protein kinase pathway by SHIP-1, a lipid phosphatase that interacts with the adaptor molecule Dok-3
PubMed
8248196
Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation
INHIBITION
PubMed
12198493
Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1
TIAM1
Entrez Gene
1612
INHIBITION
Ca_2+_inactive
CDKN1B_inactive
PubMed
12244301
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization
Entrez Gene
5829
ACTIVATION
TP53
PubMed
11251083
Mechanism in the sequential control of cell morphology and S phase entry by epidermal growth factor involves distinct MEK/ERK activations
PubMed
7722458
The intracellular signal transduction mechanism of interleukin 5 in eosinophils: the involvement of lyn tyrosine kinase and the Ras-Raf-1-MEK-microtubule-associated protein kinase pathway
PubMed
21876001
Ras-induced and extracellular signal-regulated kinase 1 and 2 phosphorylation-dependent isomerization of protein tyrosine phosphatase (PTP)-PEST by PIN1 promotes FAK dephosphorylation by PTP-PEST
ACTIVATION
PubMed
17510057
PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding
PubMed
15302099
Requirement of MKK4 and MKK7 for CdCl2- or HgCl2-induced activation of c-Jun NH2-terminal kinase in mouse embryonic stem cells
RASGAPs.family
PubMed
21199877
The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2
IGF1R
KRAS
ACTIVATION
RASSF1_inactive
TGFA
ZDHHC9
AR
PubMed
18030348
PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis
GRB2-SOS1/2
GRB2-SOS1/2.complex
Rho GTPases.family_inactive
PubMed
1851250
Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils
Entrez Gene
6788
PubMed
10490027
Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP
platelet-derived growth factor receptor
PDGFR.complex
HRAS_inactive
INHIBITION
PubMed
11389892
B cell receptor signaling involves physical and functional association of FAK with Lyn and IgM
AKT1S1_inactive
PubMed
11231573
Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells
PubMed
15866172
Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases
FLT3
Entrez Gene
5217
ACTIVATION
ACTIVATION
PRKCA
IGF1
PubMed
11173924
Neuregulin-induced association of Sos Ras exchange protein with HER2(erbB2)/HER3(erbB3) receptor complexes in Schwann cells through a specific Grb2-HER2(erbB2) interaction
INHIBITION
PubMed
9393871
The multiple endocrine neoplasia type 2B point mutation switches the specificity of the Ret tyrosine kinase towards cellular substrates that are susceptible to interact with Crk and Nck
ACTIVATION
Entrez Gene
5037
Entrez Gene
4193
MDM2
ACTIVATION
PRKC.family_inactive
ACTIVATION
IGF2
Entrez Gene
472
PubMed
10801816
The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras
RHOA
S1P
Entrez Gene
5879
ACTIVATION
ACTIVATION
PA
DAPK1
ACTIVATION
MST1
Translation
ACTIVATION
PubMed
15618521
Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1
Entrez Gene
387
INHIBITION
PIP3
Entrez Gene
4485
PubMed
19576207
Single low-dose administration of pharmacological inhibitor of mitogen-activated ERK kinase to the adventitia of the injured rat carotid artery suppresses neointima formation and inhibits nuclear ERK signaling
PubMed
17889669
RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein
HDAC1
RALB
HRAS
ACTIVATION
PubMed
8479540
The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1
PubMed
17053865
A PI3K pathway mediates hair cell survival and opposes gentamicin toxicity in neonatal rat organ of Corti
CDKN1A_DNA
PubMed
20624651
Functional variants of the sphingosine-1-phosphate receptor 1 gene associate with asthma susceptibility
ACTIVATION
Entrez Gene
2353
Entrez Gene
2549
Entrez Gene
5782
FLT3LG
PubMed
11875099
GnRH activates ERK1/2 leading to the induction of c-fos and LHbeta protein expression in LbetaT2 cells
PLCE1
PubMed
8630736
Regulation of Btk function by a major autophosphorylation site within the SH3 domain
RAF.family
ACTIVATION
RAF.family_inactive
PubMed
12515821
Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1
PubMed
21480388
Fyn is induced by Ras/PI3K/Akt signaling and is required for enhanced invasion/migration
AR_DNA
CTTN_inactive
PubMed
8131746
Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues
INHIBITION
ACTIVATION
ECM.family
TGFA
HRAS
ETS1
RHOA
INHIBITION
PubMed
1849075
Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase)
ACTIVATION
ACTIVATION
MDM2_inactive
PubMed
11030146
Phosphorylation and nuclear exclusion of the forkhead transcription factor FKHR after epidermal growth factor treatment in human breast cancer cells
myosin II.complex_inactive
BRAF
PubMed
12871843
Role of c-jun N-terminal kinase in the induced release of GM-CSF, RANTES and IL-8 from human airway smooth muscle cells
Entrez Gene
2308
PTPN12
Translation
PubMed
17386266
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
PubMed
22020193
Involvement of the PI3K/Akt pathway in myxoid/round cell liposarcoma
PubMed
15084259
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
PubMed
20639885
The C terminus of p53 binds the N-terminal domain of MDM2
PubMed
9812896
Regulation of cell death protease caspase-9 by phosphorylation
Entrez Gene
8976
GRB2
ACTIVATION
Entrez Gene
2316
PubMed
9405455
Vinculin is associated with the E-cadherin adhesion complex
PubMed
15616583
Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK
ChEBI
16337
PubMed
16339969
Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms
Entrez Gene
2323
Entrez Gene
2322
CDKN1A
PubMed
12176742
Osmotic stress-induced remodeling of the cortical cytoskeleton
NRAS
PubMed
11042193
Phospholipase C-gamma 2 couples Bruton's tyrosine kinase to the NF-kappaB signaling pathway in B lymphocytes
ACTIVATION
PubMed
10572067
Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity
RhoGAPs.family
PIN1
PubMed
12593858
Activation of phospholipase D1 by ADP-ribosylated RhoA
Spike DB
WEB:0003700
INHIBITION
ACTIVATION
PLC-gamma.family
ACTIVATION
PI(4,5)P2
PubMed
12648464
Epidermal growth factor receptor: mechanisms of activation and signalling
KIT
ERBB3
PubMed
11882288
Cadherin-directed actin assembly: E-cadherin physically associates with the Arp2/3 complex to direct actin assembly in nascent adhesive contacts
PubMed
10377264
Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor
Entrez Gene
10928
S1PR1
ACTIVATION
RET
taxonomy
9606
Ca_2+
PubMed
12134164
Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism
PubMed
18644866
Filamin A links sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 at lamellipodia to orchestrate cell migration
BCAR1
IGF2R
INHIBITION
S1P
CDKN1A_inactive
PhysicalInteraction [EGFR -- ERBB2 ]
Entrez Gene
1020
Entrez Gene
1026
Entrez Gene
1027
PubMed
16717130
Paxillin phosphorylation at Ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamics
ACTIVATION
RASSF5
PubMed
9843217
ATM associates with and phosphorylates p53: mapping the region of interaction
ChEBI
16595
CDK5
PubMed
15613447
The role of fibroblast growth factors and their receptors in prostate cancer
MAP2K4
PubMed
21779492
Ras, an actor on many stages: posttranslational modifications, localization, and site-specified events
FOS_inactive
PubMed
21779497
RAS Interaction with PI3K: More Than Just Another Effector Pathway
PTEN
PLD1_inactive
ChEBI
29108
PubMed
21779498
The RalGEF-Ral Effector Signaling Network: The Road Less Traveled for Anti-Ras Drug Discovery
PubMed
21779499
Differential Regulation of RasGAPs in Cancer
ACTIVATION
ACTIVATION
ARP2/3 complex
ARP2/3.complex
ACTIVATION
MIR181C
ACTIVATION
RALB_inactive
GRB2_inactive
STK3
PubMed
9642236
Involvement of Ras in Bruton's tyrosine kinase-mediated JNK activation
PubMed
21283725
The Ras-PI3K signaling pathway is involved in clathrin-independent endocytosis and the internalization of influenza viruses
PLC-gamma.family_inactive
Spike DB
WEB:0003740
BAD
Entrez Gene
51114
EGF
PubMed
1852007
The ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site
Spike DB
TAU:F-329408
PubMed
10207050
Cumulative effect of phosphorylation of pRB on regulation of E2F activity
ELK1
SPHK1
Entrez Gene
2113
SOS1
Spike DB
TAU:F-329659
PTEN
MAPK8
PubMed
17440071
P21-activated protein kinase is overexpressed in hepatocellular carcinoma and enhances cancer metastasis involving c-Jun NH2-terminal kinase activation and paxillin phosphorylation
RhoGEFs.family
PTK2_inactive
Ca_2+
BRAF
RAC1_inactive
AKT1S1
PFNs.family
ACTIVATION
ACTIVATION
ACTIVATION
BCAR1_inactive
ACTIVATION
PubMed
15718470
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
PubMed
8490966
Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor
RASSF1
ACTIVATION
PubMed
17962350
Nuclear exclusion of forkhead box O and Elk1 and activation of nuclear factor-kappaB are required for C2C12-RasV12C40 myoblast differentiation
PubMed
19880753
Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors
IGF1R_inactive
Entrez Gene
11186
RAC1
ChEBI
18348
ACTIVATION
ACTIVATION
MET_inactive
SHC1
FGFR.family
IP3
PTPN12_inactive
Rho GTPases.family
PubMed
14737178
JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis
PubMed
11350930
Role of transglutaminase II in retinoic acid-induced activation of RhoA-associated kinase-2
PubMed
21686269
RLIP76 (RalBP1): The first piece of the structural puzzle
CDC42_inactive
VCL
GTP-Ras.complex_inactive
MAP3K4
WASL
ACTIVATION
PubMed
16861033
C1 domains exposed: from diacylglycerol binding to protein-protein interactions
Spike DB
WEB:0003786
PubMed
9169478
T cell proliferation in response to interleukins 2 and 7 requires p38MAP kinase activation
ELK1
ACTIVATION
PubMed
7505204
Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells
ARAF
PubMed
12024041
The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation
PubMed
11401320
FGF-1 and FGF-2 modulate the E-cadherin/catenin system in pancreatic adenocarcinoma cell lines
PubMed
143236
Nonmuscle contractile proteins: the role of actin and myosin in cell motility and shape determination
PubMed
21079800
Cortactin phosphorylated by ERK1/2 localizes to sites of dynamic actin regulation and is required for carcinoma lamellipodia persistence
ELK1_inactive
PubMed
12065577
Involvement of cell-cell interactions in the rapid stimulation of Cas tyrosine phosphorylation and Src kinase activity by transforming growth factor-beta 1
ACTIVATION
ACTIVATION
RAL-GEFs.family_inactive
PubMed
14517206
RhoA/ROCK regulation of neuritogenesis via profilin IIa-mediated control of actin stability
PubMed
10080542
Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells
MKK1/2.family_inactive
PubMed
10085258
E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation
filamentous actin
f-actin.complex
ChEBI
16618
Spike DB
WEB:0002414
ACTIVATION
DAPK1
CDKN1B
Entrez Gene
6416
PubMed
9346240
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
MYC
PubMed
10998413
Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis
ACTIVATION
JUN_inactive
PubMed
19579266
Efficient activation of p53 pathway in A549 cells exposed to L2, a novel compound targeting p53-MDM2 interaction
AKT1
FOXO1
FOXO1
INHIBITION
DAG
MAP3K4_inactive
Entrez Gene
4254
Entrez Gene
5900
PubMed
11598012
PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization
RALGDS
GTP-Ras.complex
S1PR1_inactive
PubMed
16574237
Signaling functions of phosphatidic acid
ACTIVATION
Entrez Gene
84335
VCL
PubMed
20980691
IGF2 actions on trophoblast in human placenta are regulated by the insulin-like growth factor 2 receptor, which can function as both a signaling and clearance receptor
NTRK1
ACTIVATION
PXN
Entrez Gene
4893
ACTIVATION
PhysicalInteraction [GRB2 -- PTK2 ]
PubMed
11726515
Tyrosine phosphorylation of Grb2 by Bcr/Abl and epidermal growth factor receptor: a novel regulatory mechanism for tyrosine kinase signaling
ACTIVATION
PubMed
7673236
Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity
PubMed
20080834
Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis
CCND1_inactive
MST1_inactive
PubMed
11729323
Phosphatidic acid-mediated mitogenic activation of mTOR signaling
SPHK1
PubMed
18568040
Ras oncogenes: split personalities
RASSF5
RASGEFs.family
PubMed
8400019
Receptor-mediated signalling pathways acting through hydrolysis of membrane phospholipids in cardiomyocytes
CASP9_inactive
MDM2
Entrez Gene
4233
BAD
Entrez Gene
7157
Entrez Gene
3725
EGFR
PubMed
15746962
The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling
PI3K - p85.family
PFN2_inactive
PubMed
9409807
Profilins as regulators of actin dynamics
CDC42
Entrez Gene
4216
ATM
PubMed
9488663
Identification of Nore1 as a potential Ras effector
JUN.family
ACTIVATION
PhysicalInteraction [GAB1 -- SHC1 ]
ACTIVATION
ACTIVATION
BAD_inactive
ACTIVATION
FOXO1_inactive
PubMed
10757792
Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein
ACTIVATION
IGF2
Entrez Gene
9564
ACTIVATION
PubMed
11136975
The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest
PubMed
1846706
Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product
GRB2
Homo sapiens
ACTIVATION
DAG_inactive
RET
Entrez Gene
2885
NKX3-1
MAP2K4_inactive
PI(4,5)P2
Spike DB
TAU:F-000011
Spike DB
TAU:F-000013
MST1
Spike DB
TAU:F-000014
MET
Spike DB
TAU:F-000019
ACTIVATION
Entrez Gene
4824
ACTIVATION
MIR181C
Entrez Gene
5599
PubMed
16516204
Activation of ErbB2 by 2-methyl-1,4-naphthoquinone (menadione) in human keratinocytes: role of EGFR and protein tyrosine phosphatases
Entrez Gene
369
Spike DB
TAU:F-000020
Entrez Gene
367
SHC1
S1P_inactive
ACTIVATION
Spike DB
TAU:F-000021
PubMed
17145710
IntAct--open source resource for molecular interaction data
ACTIVATION
ACTIVATION
ACTIVATION
ACTIVATION
PubMed
9733515
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
Entrez Gene
5170
PubMed
9733514
Enhanced phosphorylation of p53 by ATM in response to DNA damage
AR
Entrez Gene
4609
alpha- /beta1 integrin
Integrin, alpha/beta1.complex
PIN1
KRAS
PubMed
1322798
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling
FLNA_inactive
MET
SOS1
Entrez Gene
5300
IP3_inactive
PXN
PubMed
15766527
RAS is regulated by the let-7 microRNA family
INHIBITION
RAL-GEFs.family
Entrez Gene
6464
CASP9
Entrez Gene
5578
ACTIVATION
PubMed
20606160
Platelet-derived growth factor (PDGF)-PDGF receptor interaction activates bone marrow-derived mesenchymal stromal cells derived from chronic lymphocytic leukemia: implications for an angiogenic switch
INHIBITION
Entrez Gene
6093
SOS1_inactive
Entrez Gene
5979
CDKN1A_RNA
Integrin, alpha/beta1.complex_inactive
FOS/F.family
PubMed
19749794
Pro-proliferative FoxM1 is a target of p53-mediated repression
PubMed
12881490
A Ras activation pathway dependent on Syk phosphorylation of protein kinase C
Ras GTPases.family
ERBB2_inactive
ETS1
MIR143
PubMed
14693367
Ets ternary complex transcription factors
ERK.family
Entrez Gene
999
KITLG
INHIBITION
Entrez Gene
6654
ACTIVATION
Entrez Gene
595
ACTIVATION
Spike
PubMed
10995762
p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1)
PubMed
10617656
Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation
AKT1_inactive
Entrez Gene
998
AKT1S1
INHIBITION
VCL_inactive
PubMed
16697957
NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss
ACTIVATION
ACTIVATION
ACTIVATION
STK3
Entrez Gene
5747
ACTIVATION
PubMed
20484029
Inhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signaling
Ras GTPases.family_inactive
PubMed
12042314
Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization
PDPK1
ARAF
PubMed
16083947
Ras initiates phosphatidyl-inositol-3-kinase (PI3K)/PKB mediated signalling pathways in untransformed human peripheral blood T lymphocytes
PubMed
2984676
Tumor-promoting phorbol diesters cause the phosphorylation of epidermal growth factor receptors in normal human fibroblasts at threonine-654
CTTN
Entrez Gene
572
PubMed
9305638
MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42
AR_RNA
ACTIVATION
ACTIVATION
PubMed
20458382
Structure of the EGF receptor transactivation circuit integrates multiple signals with cell context
PubMed
12640114
p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction
PubMed
17517883
The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1
PubMed
10918572
Unique carboxyl-terminal sequences of wild type and alternatively spliced variant forms of transforming growth factor-alpha precursors mediate specific interactions with ErbB4 and ErbB2
PubMed
10896658
Hepatocyte growth factor-induced differential activation of phospholipase cgamma 1 and phosphatidylinositol 3-kinase is regulated by tyrosine phosphatase SHP-1 in astrocytes
AKT1
AP-1_I.complex_RNA
PubMed
19377290
AKT1 mediates bypass of the G1/S checkpoint after genotoxic stress in normal human cells
Entrez Gene
5337
ACTIVATION
Entrez Gene
5728
PDGFR.complex_inactive
MYC
FLT3LG
ACTIVATION
FLNA
PubMed
10871633
c-Jun inhibits transforming growth factor beta-mediated transcription by repressing Smad3 transcriptional activity
ACTIVATION
PubMed
21918248
[The mechanism of phospholipase C1 activation]
Spike DB
TAU:F-329768
PubMed
11311142
Determination of interaction sites of phospholipase D1 for RhoA
PubMed
9305878
Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110beta is synergistically activated by the betagamma subunits of G proteins and phosphotyrosyl peptide
PFN2
Entrez Gene
8877
IP3
PubMed
9804835
The Gab1 protein is a docking site for multiple proteins involved in signaling by the B cell antigen receptor
ACTIVATION
STK3_inactive
ACTIVATION
TP53
ACTIVATION
Spike DB
ELK:F-000030
JUN
PubMed
9104825
Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis
ARP2/3.complex_inactive
MIR143
MAP2K4
ACTIVATION_UNKMECH
Class I phosphoinositide-3-kinase
PI3K.complex
CDC42
PubMed
20711231
A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells
myosin II
myosin II.complex
NTRK1
Spike DB
WSC:F-000017
PIN1_inactive
BCAR1
PubMed
11331603
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage
INHIBITION
ACTIVATION
ACTIVATION
PEBP1
ROCK1
PTK2
ACTIVATION
PubMed
18830272
The EGFR is required for proper innervation to the skin
ACTIVATION
PEBP1
PubMed
15632134
Peroxisome proliferator-activated receptor-beta/delta inhibits epidermal cell proliferation by down-regulation of kinase activity
PubMed
11179219
Phospholipase C(epsilon): a novel Ras effector
PubMed
19137007
Role of miR-143 targeting KRAS in colorectal tumorigenesis
PubMed
8155326
Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses
ACTIVATION
PubMed
16713569
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
ACTIVATION
ACTIVATION
PubMed
18596699
Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II
ZDHHC9
RALA_inactive
ACTIVATION
ACTIVATION
INHIBITION
ACTIVATION
PubMed
12748190
p21/CDKN1A mediates negative regulation of transcription by p53
PFN2
PubMed
21565291
Gain-of-function mutations of ARHGAP31, a Cdc42/Rac1 GTPase regulator, cause syndromic cutis aplasia and limb anomalies
ERBB2
MAPK8
PubMed
15184909
Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas
PubMed
1460037
Interleukin 2-induced activation of Ras requires two domains of interleukin 2 receptor beta subunit, the essential region for growth stimulation and Lck-binding domain
CDH1_inactive
PubMed
2543678
All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor
MAPK8_inactive
SOS1/2.family
Eps8-Abi1-Sos1
Eps8-Abi1-Sos1.complex
JUN
ACTIVATION
Entrez Gene
5894
ACTIVATION
ACTIVATION
PDPK1_inactive
Entrez Gene
5899
DAG
Entrez Gene
5898
CDKN1B
Entrez Gene
3480
Entrez Gene
3481
CDH1
ACTIVATION
ChEBI
37550
Entrez Gene
3482
Spike DB
WEB:0003844
Actin.family_inactive
PubMed
8259209
Proteins regulating Ras and its relatives
PubMed
11687500
Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer
SHC1_inactive
intact:EBI-960623
PhysicalInteraction [HRAS -- RASSF5 ]
HDAC1
Entrez Gene
3082
PubMed
7744004
A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20
RALBP1_inactive
MYC_inactive
FGFR.family_inactive
Entrez Gene
2475
PubMed
2987962
Platelet-derived growth factor mimics phorbol diester action on epidermal growth factor receptor phosphorylation at threonine-654
PubMed
19933846
Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling
FLNA
MKK1/2.family
SPHK1_inactive
ACTIVATION
Entrez Gene
3479
ACTIVATION
PhysicalInteraction [Complex ARP2/3 {} -- CTTN ]
PubMed
9651358
Structure-function analysis of FLT3 ligand-FLT3 receptor interactions using a rapid functional screen
ACTIVATION
RAC1
PubMed
1375232
A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses
INHIBITION
PA
RALBP1
ACTIVATION
Translation
Entrez Gene
3265
INHIBITION
PLC.family
PubMed
7518388
Coordinate actions of calcium and protein kinase-C in the expression of primary response genes in pituitary gonadotrophs
RALA
FGF.family
PubMed
11741957
A lipid-regulated docking site on vinculin for protein kinase C
NKX3-1
ROCK1
INHIBITION
RASSF1
CCND1
ACTIVATION
MTOR
Entrez Gene
3065
FOS
ACTIVATION
HGF
IGF1R
PubMed
21163364
Dose-dependent mutual regulation between Wip1 and p53 following UVC irradiation
ACTIVATION
FLT3_inactive
ERBB3
RAF1_inactive
Spike DB
ELK:F-329919
PubMed
20553968
Phospholipase C is a key enzyme regulating intracellular calcium and modulating the phosphoinositide balance
Spike DB
ELK:F-329918
ROCK1/2.family_inactive
PubMed
16341064
Exploiting the PI3K/AKT pathway for cancer drug discovery
PubMed
8321321
Protein kinase C alpha activates RAF-1 by direct phosphorylation
ACTIVATION
BRAF_inactive
RAF1
NRAS_inactive
Spike DB
ELK:F-329926
Entrez Gene
1901
PubMed
18463697
Sensing and integration of Erk and PI3K signals by Myc
PRKCA
Spike DB
ELK:F-329924
PubMed
1322500
Raf-1 activates MAP kinase-kinase
TIAM1
Spike DB
ELK:F-329920
ACTIVATION
PubMed
7680037
Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem cell factor
INHIBITION
ACTIVATION
PubMed
9561845
Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development
CDK5
Entrez Gene
2017
INHIBITION
ACTIVATION
ACTIVATION
intact:EBI-1191199,intact:EBI-1191206,intact:EBI-727492,intact:EBI-762404
PhysicalInteraction [CDH1 -- CTNNB1 ]
RALBP1
Entrez Gene
406935
ACTIVATION
ACTIVATION
PAK1
PhysicalInteraction [CTNNB1 -- VCL ]
PubMed
16129412
Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor
Spike DB
WEB:0003669
Entrez Gene
2002
PubMed
2549071
Transient increase in phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol trisphosphate during activation of human neutrophils
intact:EBI-985666,intact:EBI-985686
PhysicalInteraction [HRAS -- RASSF1 ]
Spike DB
TAU:F-329912
Spike DB
TAU:F-329911
GAB1
PubMed
12426395
MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation
ACTIVATION
CASP9
PubMed
15242766
Interaction of cortactin and Arp2/3 complex is required for sphingosine-1-phosphate-induced endothelial cell remodeling
WASL_inactive
INHIBITION
KIT_inactive
PubMed
12947395
MAPK pathways in radiation responses
PXN_inactive
let-7a.family
Entrez Gene
406957
ERK.family_inactive
WASL
ETS1_inactive
MTOR_inactive
ChEBI
18035
NRAS
Entrez Gene
1956
PubMed
8052307
Phosphatidylinositol-3-OH kinase as a direct target of Ras
Entrez Gene
1950
PubMed
11857081
The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1
PI3K.complex_inactive
PubMed
10781580
GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex
ACTIVATION
PTPN12
ERBB2
PubMed
21357737
Pathological signaling via PDGFR{alpha} involves chronic activation of Akt and suppression of p53
S1PR1