PubMed
19412162
F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage
PubMed
21741842
miRNA response to DNA damage
Entrez Gene
7471
MIR221
PubMed
19126397
MicroRNA-dependent regulation of cKit in cutaneous melanoma
ACTIVATION
JAG1_inactive
Entrez Gene
5629
GJB6
GFI1_inactive
PubMed
15678131
The anaphase-promoting complex: a key factor in the regulation of cell cycle
Entrez Gene
26271
Entrez Gene
8454
PubMed
12824889
hCDC4b, a regulator of cyclin E, as a direct transcriptional target of p53
PubMed
17494702
Selective cochlear degeneration in mice lacking the F-box protein, Fbx2, a glycoprotein-specific ubiquitin ligase subunit
Translation
Entrez Gene
182
INHIBITION
CDKN1B
MIR222
HDAC1
MYC
PubMed
18413744
MicroRNAs 221 and 222 bypass quiescence and compromise cell survival
PubMed
17081987
Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex
GFI1
AKT1
Translation
TP53
MYCN
CDKN1C_inactive
Entrez Gene
8841
ESR1
PubMed
15465029
Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity
PhysicalInteraction [GFI1 -- HDAC1 ]
Translation
Translation
Entrez Gene
55294
SKP1
PubMed
19424584
Co-suppression of miR-221/222 cluster suppresses human glioma cell growth by targeting p27kip1 in vitro and in vivo
PubMed
16495313
Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear
GFI1
Entrez Gene
407007
Entrez Gene
407006
PubMed
19111882
Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma
POU4F3_RNA
POU4F3
PubMed
20399964
MYC in oncogenesis and as a target for cancer therapies
CDKN1B_RNA
PubMed
10706881
c-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover
CCND1
GJB2
ACTIVATION
PubMed
19730150
Antisense inhibition of microRNA-21 or -221 arrests cell cycle, induces apoptosis, and sensitizes the effects of gemcitabine in pancreatic adenocarcinoma
NTF3
NTF3_RNA
CCND1_inactive
Entrez Gene
3815
ZBTB16
KIT
PubMed
15109709
The cochlear F-box protein OCP1 associates with OCP2 and connexin 26
NOTCH1
INHIBITION
PubMed
17331196
Lhx3, a LIM domain transcription factor, is regulated by Pou4f3 in the auditory but not in the vestibular system
Entrez Gene
26232
PubMed
18417445
The promyelocytic leukemia zinc finger-microRNA-221/-222 pathway controls melanoma progression through multiple oncogenic mechanisms
INHIBITION
GJB3
GJB6
INHIBITION
Entrez Gene
7157
BDNF
INHIBITION
INHIBITION
STAT1_inactive
PhysicalInteraction [GFI1 -- HDAC3 ]
MIR181A2
BDNF
GJB6_inactive
PubMed
19723763
PLZF is a regulator of homeostatic and cytokine-induced myeloid development
CDKN1C
PubMed
17721077
Regulation of p27Kip1 by miRNA 221/222 in glioblastoma
BAX
NOTCH1_RNA
Translation
FBXO5
PubMed
17569667
miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1
PubMed
12874834
Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism
CDKN1C
BAX
PubMed
17646408
The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
SCF-FBX4-aLpha-B Crystallin.complex
SCF-FBX4-aLpha-B Crystallin
PubMed
16023596
The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase
NOTCH1_DNA
BDNF_RNA
FBXO5_inactive
LHX3
CDKN1B
Entrez Gene
2707
Entrez Gene
2706
PubMed
19829074
p27 as Jekyll and Hyde: regulation of cell cycle and cell motility
GFI1_RNA
FBXW7
RTKs.family
GFI1_DNA
PubMed
16288292
Perturbations of the AKT signaling pathway in human cancer
Entrez Gene
7704
HDAC1
Entrez Gene
4851
MYC_inactive
INHIBITION
Entrez Gene
8022
PubMed
16330772
MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation
SCF-SKP2.complex
SCF-SKP2 ubiquitin ligasse
ACTIVATION
ACTIVATION
PubMed
19047647
Coordinated control of connexin 26 and connexin 30 at the regulatory and functional level in the inner ear
FBXO5
Entrez Gene
2099
Homo sapiens
PubMed
19050930
Digenic inheritance of non-syndromic deafness caused by mutations at the gap junction proteins Cx26 and Cx31
MIR221
KIT
CUL1
Translation
ACTIVATION
PubMed
18708351
MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1
ATOH1
FBXO2
taxonomy
9606
HHIP
HDAC2
LHX3_DNA
Entrez Gene
207
MIR181A2
SCF-FBXO31.complex
SCF-FBXO31
CUL1
PubMed
15199159
Noncatalytic requirement for cyclin A-cdk2 in p27 turnover
MYCN
Entrez Gene
5459
HDAC3
ACTIVATION
INHIBITION
CCND1
CUL1_RNA
PubMed
17145710
IntAct--open source resource for molecular interaction data
Entrez Gene
3066
Entrez Gene
1027
Entrez Gene
1028
intact:EBI-1190099
PhysicalInteraction [FBXW7 -- MYC ]
Entrez Gene
3065
MLL
LHX3
BAX_RNA
Entrez Gene
6772
PubMed
19273599
miR-181a regulates cap-dependent translation of p27(kip1) mRNA in myeloid cells
MIR145
INHIBITION
INHIBITION
Entrez Gene
4609
CUL1_DNA
FBXW7_RNA
Translation
Entrez Gene
4613
ACTIVATION
PubMed
16989775
Expression of mouse Fbxw7 isoforms is regulated in a cell cycle- or p53-dependent manner
GJB2
ESR1_inactive
ACTIVATION
INHIBITION
NOTCH1
BDNF_DNA
MIR145
Translation
HHIP
PubMed
20098684
MicroRNA-145 targets YES and STAT1 in colon cancer cells
LHX3_RNA
PubMed
15254021
Transcription profiling of inner ears from Pou4f3(ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene
Entrez Gene
627
ATOH1_RNA
INHIBITION
JAG1
ACTIVATION
INHIBITION
INHIBITION
PubMed
18495817
Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode
STAT1
CDKN1B_inactive
ATOH1
INHIBITION
TP53
Entrez Gene
64399
ACTIVATION
ACTIVATION
SKP1
POU4F3_DNA
PhysicalInteraction [FBXO2 -- GJB2 ]
PubMed
17992189
Identification of a novel p53-dependent activation pathway of STAT1 by antitumour genotoxic agents
INHIBITION
Entrez Gene
406937
STAT1
ESR1
ACTIVATION
Translation
Translation
Entrez Gene
2672
Spike DB
TAU:F-329923
Entrez Gene
595
PubMed
18652815
Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia
MLL
JAG1_RNA
Spike
Translation
SCF.complex
SCF-FBXW7
INHIBITION
PubMed
18521080
MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma
PhysicalInteraction [FBXW7 -- MYCN ]
ACTIVATION
PubMed
16682404
A novel route for F-box protein-mediated ubiquitination links CHIP to glycoprotein quality control
INHIBITION
ATOH1_DNA
POU4F3
FBXW7_DNA
mir-221.family
GJB2_inactive
ACTIVATION
WNT1
Entrez Gene
6500
WNT1
ACTIVATION
PhysicalInteraction [FBXO2 -- HHIP ]
PubMed
19107213
The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice
NTF3_DNA
Translation
NTF3
BAX_DNA
KIT_inactive
INHIBITION
PubMed
16915296
Divorcing ARF and p53: an unsettled case
HDAC3
PhysicalInteraction [FBXO2 -- SKP1 ]
PhysicalInteraction [GFI1 -- HDAC2 ]
PROX1
Spike DB
CEN:F-329968
Entrez Gene
10804
PhysicalInteraction [LHX3 -- POU4F3 ]
Entrez Gene
474
CDKN1B_DNA
ACTIVATION
Entrez Gene
4297
PhysicalInteraction [GJB2 -- GJB3 ]
Entrez Gene
406954
GJB3
ACTIVATION
JAG1_DNA
Entrez Gene
4908
NOTCH1_inactive
HDAC2
PROX1
JAG1
FBXW7
AKT1
ZBTB16
PubMed
18790736
MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer
PubMed
16997566
Menin and its interacting proteins: elucidation of menin function
MIR222
FBXO2
Entrez Gene
581
MYC