Translation
ACTIVATION
ACTIVATION
Entrez Gene
4133
MCL1_RNA
INHIBITION
CDKN1A
EDN1_inactive
GFI1_inactive
ATM-dependent phosphorylation and accumulation of endogenous BLM protein in response to ionizing radiation
PubMed
11146546
INHIBITION
OAS.family
LFNG
ACTIVATION
GPR98
The protooncogene c-Maf is an essential transcription factor for IL-10 gene expression in macrophages
PubMed
15749884
INHIBITION
PhysicalInteraction [GPR98 -- MYO7A ]
HMOX1
Entrez Gene
65217
Entrez Gene
10083
SPARC
ACTIVATION
TCF.complex
Ternary Complex Factor
PhysicalInteraction [OTOF -- SNAP25 ]
ACTIVATION
Translation
Translation
ACTIVATION
APC_DNA
Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51
PubMed
11278509
RBPJ
GNRH1
CASP6
Entrez Gene
7275
ACTIVATION
Dual-specificity phosphatase DUSP1 protects overactivation of hypoxia-inducible factor 1 through inactivating ERK MAPK
PubMed
16081065
RPS6KA1
Entrez Gene
23621
CASP6
CTNNB1
ACTIVATION
TIMP1
Entrez Gene
2745
GADD45B
OTOF
ACTIVATION
PIK3R1
CDKN1B_RNA
APC/C-FZR1.complex_inactive
PDGF.family
EGFR
MIR29C
CCL2
Translation
INHIBITION
Myosin VIIA is specifically associated with calmodulin and microtubule-associated protein-2B (MAP-2B)
PubMed
11171103
LFNG
MCL1_inactive
INHIBITION
BCL2L1_RNA
SIX1_DNA
PDGFA
DUSP1_inactive
intact:EBI-875456,intact:EBI-875497
PhysicalInteraction [EGFR -- ERBB4 ]
INHIBITION
MKP-1 represses JNK-mediated apoptosis via NF-kappa B regulation
PubMed
18508759
Translation
ACTIVATION
ACTIVATION
SIX1
Actin.family
Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo
PubMed
18535259
INHIBITION
Translation
EGFR_inactive
ACTIVATION
Entrez Gene
5295
GADD45A_DNA
DACH2_RNA
GJB6_inactive
BAX
PML3 Orchestrates the Nuclear Dynamics and Function of TIP60
PubMed
19150978
GNRHR_inactive
INHIBITION
Direct interaction of otoferlin with syntaxin 1A, SNAP-25, and the L-type voltage-gated calcium channel Cav1.3
PubMed
19004828
ACTIVATION
CDKN2A
Inflammasome.complex
Gadd45a contributes to p53 stabilization in response to DNA damage
PubMed
14627995
DLX5_RNA
ACTIVATION
Translation
PAK.family
Entrez Gene
2706
COL1A1_DNA
ATR_DNA
INHIBITION
TFRC
ACTIVATION
FGF1
MAP2K1_inactive
Translation
INHIBITION
IL18
ACTIVATION
STAT3_inactive
SCF-SKP2.complex
SCF-SKP2 ubiquitin ligasse
ACTIVATION
Inhibitors of differentiation and DNA binding (Ids) regulate Math1 and hair cell formation during the development of the organ of Corti
PubMed
16407553
Tumor necrosis factor-alpha induces Bax-Bak interaction and apoptosis, which is inhibited by adenovirus E1B 19K
PubMed
11571294
RAD51
ACTA1
Transcriptional regulation of the interleukin-6 gene in mesangial cells
PubMed
10405202
ACTIVATION
ACTIVATION
MIR106A
SMAD4_RNA
ACTIVATION
Entrez Gene
815
MIR29C
INHIBITION
INHIBITION
ACTIVATION
ACTIVATION
ACTIVATION
ACTIVATION
IL6_RNA
EPOR
FOS_RNA
SPARC_inactive
ATF2_inactive
ACTIVATION
ACTIVATION
ACTIVATION
BAX_RNA
XIAP
ACTIVATION
Entrez Gene
841
Isolation and properties of the FSH and LH-releasing hormone
PubMed
4930860
ACTIVATION
ACTIVATION
Entrez Gene
842
CAMK2A_inactive
Glucocorticoid-mediated gene suppression of rat cytokine-induced neutrophil chemoattractant CINC/gro, a member of the interleukin-8 family, through impairment of NF-kappa B activation
PubMed
8576166
Entrez Gene
840
Entrez Gene
839
DAPk localizes to the actin cytoskeleton by immunostaining and cell fractionation
PhysicalInteraction [DAPK1 -- Complex f-actin {} ]
A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest
PubMed
10920185
HIF1A_inactive
INHIBITION
Entrez Gene
834
Entrez Gene
836
ESR1_inactive
Translation
COL1A2_inactive
PAX8_inactive
Entrez Gene
10524
HIF1A
ACTIVATION
Differences in the association of p53 phosphorylated on serine 15 and key enzymes of homologous recombination
PubMed
15806145
SMAD4_DNA
Entrez Gene
1602
TDG
Entrez Gene
1612
Cell cycle-regulated phosphorylation of the human SIX1 homeodomain protein
PubMed
10801845
ICAM1
CDKN1B_inactive
TFRC_DNA
The phosphatase MKP1 is a transcriptional target of p53 involved in cell cycle regulation
PubMed
12890671
NRG1
Entrez Gene
861
RAD51_RNA
ACTIVATION
Entrez Gene
4170
SKP1
Translation
RB1
Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM
PubMed
15546863
AR
INHIBITION
ACTIVATION
LEF/TCFs.family
MAP2K2
MAGI1
PDGFR.complex
platelet-derived growth factor receptor
MAP2K3
Dual Regulation of Tumor Necrosis Factor-alpha-Induced CCL2/Monocyte Chemoattractant Protein-1 Expression in Vascular Smooth Muscle Cells by Nuclear Factor-kappaB and Activator Protein-1: Modulation by Type III Phosphodiesterase Inhibition
PubMed
14978197
ACTIVATION
ACTIVATION
mir-221.family
INHIBITION
CD79B
MYO5A
Entrez Gene
6500
Entrez Gene
6502
RB1_inactive
MAPK14_inactive
Entrez Gene
2290
INHIBITION
CD44
Entrez Gene
5888
Erythropoietin: physiology and pharmacology update
PubMed
12524467
Entrez Gene
2299
CD79A
ACTIVATION
Entrez Gene
474
FAS_DNA
Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double strand breaks
PubMed
17272272
ACTIVATION
IGF2
Entrez Gene
472
NGF
Entrez Gene
2798
Entrez Gene
2796
Entrez Gene
25861
Entrez Gene
4908
Entrez Gene
1647
DACH2
Apoptotic threshold is lowered by p53 transactivation of caspase-6
PubMed
12089322
INHIBITION
APC_inactive
DAPK1
AP-1-mediated invasion requires increased expression of the hyaluronan receptor CD44
PubMed
9001250
Translation
Entrez Gene
387
HSPB1
Translation
INHIBITION
Translation
Downregulation of MIRNA-1/MIRNA-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart
PubMed
18458081
PDGFA_DNA
INHIBITION
MAPKAPK2
IAP family proteins--suppressors of apoptosis
PubMed
9990849
AR_inactive
Nonionic detergents induce dimerization among members of the Bcl-2 family
PubMed
9153240
BLM
ACTIVATION
A PI3K pathway mediates hair cell survival and opposes gentamicin toxicity in neonatal rat organ of Corti
PubMed
17053865
CDKN1A_DNA
Inhibition of Notch/RBP-J signaling induces hair cell formation in neonate mouse cochleas
PubMed
16283144
CASP6_inactive
CD79A_RNA
Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway
PubMed
14757642
Entrez Gene
2353
INHIBITION
Tip60 acetyltransferase activity is controlled by phosphorylation
PubMed
12468530
H2AFX_inactive
ACTIVATION
Entrez Gene
84059
Phosphorylation and regulation of Raf by Akt (protein kinase B)
PubMed
10576742
RPS6KA1
FGF10
DUSP1_RNA
SPARC
ACTIVATION
CDKN2A_inactive
ACTIVATION
INHIBITION
ACTIVATION
ACTIVATION
TNF_DNA
Gonadotropin-releasing hormone stimulation of gonadotropin subunit transcription: evidence for the involvement of calcium/calmodulin-dependent kinase II (Ca/CAMK II) activation in rat pituitaries
PubMed
12810529
Translation
Entrez Gene
124590
Translation
RHOA_inactive
ACTIVATION
Entrez Gene
6616
NFE2L2
ACTIVATION
ACTIVATION
GJB2
ACTIVATION
ACTIVATION
ACTIVATION
A comparative study of Eya1 and Eya4 protein function and its implication in branchio-oto-renal syndrome and DFNA10
PubMed
15492887
FGF20
INHIBITION
Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells
PubMed
8621729
MAPKAPK2
INHIBITION
Transcriptional activation of the human TNF-alpha promoter by superantigen in human monocytic cells: role of NF-kappa B
PubMed
7608567
ACTIVATION
Regulation of monocyte chemoattractant protein-1 by the oxidized lipid, 13-hydroperoxyoctadecadienoic acid, in vascular smooth muscle cells via nuclear factor-kappa B (NF-kappa B)
PubMed
15081318
Entrez Gene
6195
Cellular and molecular mechanisms of liver injury
PubMed
18471544
Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis
PubMed
18694732
Translation
BDNF
Transcriptional and post-transcriptional mechanisms involved in the differential expression of LPS-induced IL-1 and TNF mRNA
PubMed
1916897
Translation
Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia
PubMed
18160714
INHIBITION
ACTIVATION
ACTIVATION
LEF/TCFs.family_inactive
Regulation of cell death protease caspase-9 by phosphorylation
PubMed
9812896
ACTIVATION
Triple layer control: phosphorylation, acetylation and ubiquitination of FOXO proteins
PubMed
15917664
Translation
INHIBITION
Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy
PubMed
18337766
ACTIVATION
Entrez Gene
56751
ACTIVATION
BDNF_RNA
PAK.family_inactive
Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK
PubMed
15616583
INHIBITION
mir-7.family
INHIBITION
INHIBITION
TNF
INHIBITION
ATM_inactive
miR-17 family miRNAs are expressed during early mammalian development and regulate stem cell differentiation
PubMed
19073166
Stress-inducible transcription factor CHOP/gadd153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanisms
PubMed
11426938
GADD45A
Calcium- and otoferlin-dependent exocytosis by immature outer hair cells
PubMed
18287496
INHIBITION
Transcriptional control of SPARC by v-Jun and other members of the AP1 family of transcription factors
PubMed
11042689
Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity
PubMed
10572067
GATA3_inactive
ACTIVATION
Translation
ACTIVATION
SOX2_DNA
Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs
PubMed
12649301
Translation
ACTIVATION
ACTIVATION
Translation
PDGFA_RNA
INHIBITION
PAX4
EGR1_inactive
dapk1, encoding an activator of a p19ARF-p53-mediated apoptotic checkpoint, is a transcription target of p53
PubMed
15608685
INHIBITION
ACTIVATION
Spike DB
CEN:F-329940
ERBB3
INHIBITION
STAT3
INHIBITION
GLRX
ACTIVATION
taxonomy
9606
GADD45A
p38.family
The murine gastrin promoter is synergistically activated by transforming growth factor-beta/Smad and Wnt signaling pathways
PubMed
15292219
Noncatalytic requirement for cyclin A-cdk2 in p27 turnover
PubMed
15199159
CDKN1A_inactive
ACTIVATION
RAB8B
MAP2K2_inactive
ACTIVATION
p53-dependent repression of the human MCL-1 gene encoding an anti-apoptotic member of the BCL-2 family: the role of Sp1 and of basic transcription factor binding sites in the MCL-1 promoter
PubMed
18208354
ATM associates with and phosphorylates p53: mapping the region of interaction
PubMed
9843217
Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons
PubMed
10085086
The role of fibroblast growth factors and their receptors in prostate cancer
PubMed
15613447
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis
PubMed
11583631
JNK.family
MIR155HG
LFNG_inactive
BCL2L1_DNA
Tumor necrosis factor alpha transcription in macrophages is attenuated by an autocrine factor that preferentially induces NF-kappaB p50
PubMed
9742085
INHIBITION
NFkB.complex_inactive
INHIBITION
mir-9.family
STAT3 as a central mediator of neoplastic cellular transformation
PubMed
17129668
Entrez Gene
3383
HCN2
HMOX1_RNA
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
PubMed
9727491
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
PubMed
9727492
p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs
PubMed
9841917
Towards a proteome-scale map of the human protein-protein interaction network
PubMed
16189514
STAT1
MIR17_RNA
SOX2_RNA
ELK1
Entrez Gene
3397
Entrez Gene
3398
Entrez Gene
3399
POU4F3_DNA
INHIBITION
MIR29A
IAP-fam.family
ACTIVATION
ARF induces autophagy by virtue of interaction with Bcl-xl
PubMed
19049976
PAX5
ACTIVATION
INHIBITION
Translation
ACTIVATION
HMX3
SIX1_RNA
Translation
RAD51
Translation
PhysicalInteraction [EYA1 -- SIX1 ]
PAX1
ACTIVATION
Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors
PubMed
11006133
APC
CDKN2A_DNA
CASP6_RNA
DAPK1_RNA
NTF3
Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells
PubMed
16481439
Entrez Gene
1277
HES5
Entrez Gene
1278
ID3
MAPK1_RNA
PhysicalInteraction [FBXO2 -- SKP1 ]
Rho GTPases.family
SNAP25_inactive
ACTIVATION
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
PubMed
17254970
ELK1
ACTIVATION
MIR17_DNA
MAF
INHIBITION
MIR17
MAP2K6
PTK2_DNA
miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42
PubMed
19079265
Wild-type p53 inhibits protein kinase CK2 activity
PubMed
11180407
PP2A.complex
Protein phosphatase 2A
JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
PubMed
8343951
ATOH1_inactive
ACTIVATION
BARHL1
IL18_RNA
ACTIVATION
BMP4
Translation
Entrez Gene
7399
ACTIVATION
EPO
PARP1
Entrez Gene
2625
MAPK3
BCL2
Prediction of mammalian microRNA targets
PubMed
14697198
ACTIVATION
EYA1
DAPK1
SMAD4
Identification of multiple nuclear factors that interact with cyclic adenosine 3',5'-monophosphate response element-binding protein and activating transcription factor-2 by protein-protein interactions
PubMed
1828107
ACTIVATION
MYC
Fra-1 negatively regulates lipopolysaccharide-mediated inflammatory responses
PubMed
19251936
MYOG
ACTIVATION
Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity
PubMed
1827203
ACTIVATION
AKT1
Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly
PubMed
15590698
PAX4
MicroRNAs 17-5p-20a-106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation
PubMed
17589498
ACTIVATION
Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity
PubMed
15465029
MAF_RNA
TrkA/B.family
BMP4_DNA
ACTIVATION
Transcriptional regulation in myelopoiesis: Hematopoietic fate choice, myeloid differentiation, and leukemogenesis
PubMed
15676205
Entrez Gene
5376
ACTIVATION
PhysicalInteraction [MAP2 -- MYO7A ]
RB1_DNA
ATR
INHIBITION
NTF3_RNA
CD44_DNA
Identification of dynamically regulated microRNA and mRNA networks in developing oligodendrocytes
PubMed
18987208
Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form
PubMed
18772196
ACTIVATION
Molecular mechanisms underlying cochlear degeneration in the tubby mouse and the therapeutic effect of sulforaphane
PubMed
19114066
MAPK14_RNA
INHIBITION
BAD
C-myb, but not B-myb, upregulates type I collagen gene expression in human fibroblasts
PubMed
9989795
BDNF
ACTIVATION
PAX5
BCL6
PAX6
MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors
PubMed
18539114
Protein phosphatase 2A (PP2A) holoenzymes regulate death-associated protein kinase (DAPK) in ceramide-induced anoikis
PubMed
20220139
INHIBITION
CDC42
CAMK2A
RAD52
Entrez Gene
4843
APC/C-FZR1.complex
Anaphase promoting complex / FZR1(CDH1) activator
Darbepoetin alfa exerts a cardioprotective effect in autoimmune cardiomyopathy via reduction of ER stress and activation of the PI3K/Akt and STAT3 pathways
PubMed
18586265
INHIBITION
SMAD2_inactive
KAT5
BCL2_RNA
Selective regulation of ICAM-1 and RANTES gene expression after ICAM-1 ligation on human renal fibroblasts
PubMed
12506144
Requirement for Map2k1 (Mek1) in extra-embryonic ectoderm during placentogenesis
PubMed
16887817
BAD_inactive
Entrez Gene
3320
ACTIVATION
Translation
EDN1_DNA
MYB_inactive
Translation
Entrez Gene
4851
EPO_DNA
IGF2
GADD45B_DNA
GNRHR_DNA
NF-kappaB and c-Jun-dependent regulation of macrophage inflammatory protein-2 gene expression in response to lipopolysaccharide in RAW 264.7 cells
PubMed
14597166
ACTIVATION
Entrez Gene
3315
GHR
RB1
IL18_inactive
MYO3A
Homo sapiens
ACTIVATION
PMP22_inactive
Entrez Gene
3717
INHIBITION
Entrez Gene
960
Glyceraldehyde-3-phosphate dehydrogenase regulates endothelin-1 expression by a novel, redox-sensitive mechanism involving mRNA stability
PubMed
18809573
ACTG1
Spike DB
TAU:F-000011
Spike DB
TAU:F-000010
JNK.family_inactive
LHX3_DNA
Spike DB
TAU:F-000019
CASP8
Spike DB
TAU:F-000018
VDR
ACTIVATION
TNFR1-TNF ALPHA.complex
TNFR1-TNF ALPHA
NLK
PhysicalInteraction [Complex B-AgR {CD79A, CD79B} -- CD19 ]
PIK3R1_inactive
HMOX1
ACTIVATION
PDCD1
HSPB1_inactive
CXCL2_DNA
Entrez Gene
71
IntAct--open source resource for molecular interaction data
PubMed
17145710
FAS
ACTIVATION
BMP4_inactive
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
PubMed
9733515
ACTIVATION
Enhanced phosphorylation of p53 by ATM in response to DNA damage
PubMed
9733514
AR
Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of Gadd45a
PubMed
12748288
ACTIVATION
Translation
CXCL2_RNA
Entrez Gene
6678
BDNF_DNA
CASP9
MYB
Entrez Gene
4803
Entrez Gene
930
CycD-Cdk4.complex_inactive
Interleukin-10 gene expression in adult T-cell leukemia
PubMed
8704212
PDCD1
ACTIVATION
Entrez Gene
545
ACTIVATION
Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein
PubMed
18252210
ACTIVATION
Ras GTPases.family
ZIC1
ERBB2_inactive
Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria
PubMed
11832478
BCL2_DNA
Regulation of the gadd45beta promoter by NF-kappaB
PubMed
12162804
CycB-Cdc2.complex
CyclinB-Cdc2 (CDK1)- M-phase-promoting factor (MPF)
Ets ternary complex transcription factors
PubMed
14693367
Entrez Gene
6657
Entrez Gene
2672
MAP2K6
Entrez Gene
596
Entrez Gene
598
GPR98
Spike
AKT1_inactive
INHIBITION
RAB8B
INHIBITION
ACTIVATION
Entrez Gene
998
INHIBITION
ACTIVATION
SNAP25
MYO7A
mir-1.family
PhysicalInteraction [ATOH1 -- HES5 ]
Translation
HES5
ACTIVATION
BARHL1_RNA
Translation
Entrez Gene
5747
YY1
Divorcing ARF and p53: an unsettled case
PubMed
16915296
Entrez Gene
983
X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes
PubMed
11359776
Caspase-3-induced gelsolin fragmentation contributes to actin cytoskeletal collapse, nucleolysis, and apoptosis of vascular smooth muscle cells exposed to proinflammatory cytokines
PubMed
9930654
Six1 controls patterning of the mouse otic vesicle
PubMed
14695375
Stressing the role of FoxO proteins in lifespan and disease
PubMed
17522590
MCL1
Entrez Gene
572
PhysicalInteraction [BLM -- RAD51 ]
Neurite outgrowth on cultured spiral ganglion neurons induced by erythropoietin
PubMed
18672044
EGR1
MAF
Entrez Gene
2690
FGF3_RNA
Structure of the EGF receptor transactivation circuit integrates multiple signals with cell context
PubMed
20458382
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
PubMed
8358790
ACTIVATION
Hypoxia-inducible factor 1, a master transcription factor of cellular hypoxic gene expression
PubMed
14517667
ACTIVATION
APC
Entrez Gene
974
AKT1
Entrez Gene
973
Nemo-like kinase induces apoptosis in DLD-1 human colon cancer cells
PubMed
12901858
apoptosome.complex
APAF1-CASP9 precursor
Entrez Gene
581
PDGFR.complex_inactive
PhysicalInteraction [EYA1 -- PAX2 ]
MYC
INHIBITION
ACTIVATION
ACTIVATION
ACTIVATION
ACTIVATION
RAD52_inactive
PCNA_RNA
Entrez Gene
2246
Entrez Gene
2248
Activation of mitogen-activated protein kinase phosphatase 2 by gonadotropin-releasing hormone
PubMed
11165042
Translation
DUSP1_DNA
Usherin, the defective protein in Usher syndrome type IIA, is likely to be a component of interstereocilia ankle links in the inner ear sensory cells
PubMed
16301217
RAD51_DNA
ACTIVATION
Entrez Gene
2255
USH1C
IAP proteins: blocking the road to death's door
PubMed
12042762
GLRX
Translation
NFkB.complex_DNA
DACH1_DNA
PhysicalInteraction [ATF2 -- FOS ]
Interaction between YY1 and the retinoblastoma protein. Regulation of cell cycle progression in differentiated cells.
PubMed
11118439
- and tumor necrosis factor alpha-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone. Functional analysis of the human icam1
PubMed
7907090
ACTIVATION
Translation
ACTIVATION
ACTIVATION
IL10
SKP1
CDC42
Translation
USH1G
TGF-beta induces apoptosis through Smad-mediated expression of DAP-kinase
PubMed
11740493
TrkA/B.family_inactive
PhysicalInteraction [USH1C -- USH1G ]
INHIBITION
PTK2
ACTIVATION
XIAP_inactive
ACTIVATION
FAS_RNA
Regulation of life and death by the zinc finger transcription factor Egr-1
PubMed
12384981
NOTCH1
ACTIVATION
Ras-like GTPases
PubMed
9395281
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
PubMed
16713569
ACTIVATION
INHIBITION
ACTIVATION
Gonadotropin-releasing hormone analogues alter gene expression of metalloproteinases and their tissue inhibitors in human breast cancer epithelial cells
PubMed
17201186
DAP-kinase is a Ca2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity
PubMed
9118961
ACTIVATION
OTX1_RNA
Zebrafish foxi one modulates cellular responses to Fgf signaling required for the integrity of ear and jaw patterning
PubMed
12702667
GAPDH
Proapoptotic BID is an ATM effector in the DNA-damage response
PubMed
16122426
A role for proapoptotic BID in the DNA-damage response
PubMed
16122425
All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor
PubMed
2543678
NF-Y-dependent cyclin B2 expression in colorectal adenocarcinoma
PubMed
17289878
EYA1_RNA
DAPK1_inactive
Deciphering the intricate regulatory mechanisms for the cellular choice between cell repair, apoptosis or senescence in response to damaging signals
PubMed
21144894
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
PubMed
7834749
Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death
PubMed
7834748
HCN2
The role of Six1 in mammalian auditory system development
PubMed
12874121
Sox2 is required for sensory organ development in the mammalian inner ear
PubMed
15846349
MAPK1
ACTIVATION
INHIBITION
ACTA1
PhysicalInteraction [MAP2K3 -- MAPK14 ]
Apoptosis and caspases regulate death and inflammation in sepsis
PubMed
17039247
BAX
The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA
PubMed
15574335
Dephosphorylation of focal adhesion kinase (FAK) and loss of focal contacts precede caspase-mediated cleavage of FAK during apoptosis in renal epithelial cells
PubMed
10224094
NLK
Spike DB
TAU:F-000008
CD79A
INHIBITION
Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis
PubMed
9670005
INHIBITION
Spike DB
TAU:F-000001
IL10_RNA
CDKN1B
MIR106A
Zic1 represses Math1 expression via interactions with the Math1 enhancer and modulation of Math1 autoregulation
PubMed
12642498
Perturbations of the AKT signaling pathway in human cancer
PubMed
16288292
CTNNB1_inactive
c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3
PubMed
17641686
RPS6KA1_inactive
MYC_inactive
SPARC_DNA
Entrez Gene
8022
FGFR.family_inactive
CK2.complex_inactive
FOS_DNA
Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival
PubMed
18039929
GAPDH
GNRHR
ICAM1
ICAM1_DNA
MicroRNA-9 modulates Cajal-Retzius cell differentiation by suppressing Foxg1 expression in mouse medial pallium
PubMed
18842901
IGF2_DNA
GPCR.family
Translation
Activation of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase by G protein and tyrosine kinase oncoproteins
PubMed
8394352
Translation
ACTIVATION
INHIBITION
Spike DB
ELK:F-329931
PAX2_inactive
Molecular regulation of monocyte chemoattractant protein-1 expression in pancreatic beta-cells
PubMed
12540607
mir-133.family
FGF3
Entrez Gene
407037
FGF3_DNA
PAX1
CD19
ACTIVATION
Translation
ACTIVATION
E2F1-3.family
MIR29B1
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/{beta}-secretase expression
PubMed
18434550
FOXG1_inactive
PAX2
The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling
PubMed
12482967
ACTIVATION
Oct3/4-Sox2.complex
Oct3/4-Sox2
ACTIVATION
INHIBITION
FOS
HIF1A
Dose-dependent mutual regulation between Wip1 and p53 following UVC irradiation
PubMed
21163364
ACTIVATION
CDKN2A_RNA
MIR15A
INHIBITION
TNF combined with IFN-alpha accelerates NF-kappaB-mediated apoptosis through enhancement of Fas expression in colon cancer cells
PubMed
12761580
RAF1_inactive
Spike DB
ELK:F-329919
Spike DB
ELK:F-329918
ACTIVATION
SOX2
BACE1
PCNA_DNA
PhysicalInteraction [OTOF -- RAB8B ]
MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins
PubMed
18390668
Exploiting the PI3K/AKT pathway for cancer drug discovery
PubMed
16341064
Spike DB
ELK:F-329910
MEK/ERK and signal transducer and activator of transcription signaling pathways modulate oncostatin M-stimulated CCL2 expression in human osteoblasts through a common transcription factor
PubMed
15022320
ACTIVATION
Translation
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
PubMed
7774019
ATF2
HES5_inactive
Entrez Gene
407021
Crosstalk of DNA glycosylases with pathways other than base excision repair
PubMed
17129768
Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK
PubMed
15082531
Down-regulation of the extracellular matrix protein SPARC in vSrc- and vJun-transformed chick embryo fibroblasts contributes to tumor formation in vivo
PubMed
10777211
The transcription factor six1 inhibits neuronal and promotes hair cell fate in the developing zebrafish (Danio rerio) inner ear
PubMed
17035528
DLX5_inactive
AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival
PubMed
11756412
PCDH15
Entrez Gene
1906
Sensing and integration of Erk and PI3K signals by Myc
PubMed
18463697
Spike DB
ELK:F-329923
Entrez Gene
407026
Spike DB
ELK:F-329922
ACTIVATION
Entrez Gene
407024
HSP90AA1
Spike DB
ELK:F-329924
Spike DB
ELK:F-329921
Spike DB
ELK:F-329920
TUB
SKP2
Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress
PubMed
11283254
Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis
PubMed
11546872
FGF10
ACTIVATION
Translation
Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning
PubMed
17567809
Translation
FOXG1
NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK
PubMed
18241676
MKK3/6.family
BCL2
Interactions in the network of Usher syndrome type 1 proteins
PubMed
15590703
NFE2L2_inactive
INHIBITION
DACH1
PCDH15_inactive
CSF1R
DFNB31_inactive
c-Myc-regulated microRNAs modulate E2F1 expression
PubMed
15944709
EYA1
Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition
PubMed
17459151
INHIBITION
MIR320A
EPO_RNA
ACTIVATION
E2F1-Regulated MicroRNAs Impair TGFbeta-Dependent Cell-Cycle Arrest and Apoptosis in Gastric Cancer
PubMed
18328430
INHIBITION
ERK.family_inactive
ACTIVATION
CDKN1B_DNA
ACTIVATION
MCL1_DNA
Entrez Gene
1958
p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1
PubMed
10551817
Entrez Gene
1956
Entrez Gene
1950
INHIBITION
GATA3_DNA
L-Maf, a downstream target of Pax6, is essential for chick lens development.
PubMed
12128206
Foxos.family
ERBB2
XIAP
Notch signalling is needed to maintain, but not to initiate, the formation of prosensory patches in the chick inner ear
PubMed
17537801
Entrez Gene
7471
COL1A2_DNA
The multiple personalities of the regulatory subunit of protein kinase CK2: CK2 dependent and CK2 independent roles reveal a secret identity for CK2beta
PubMed
15951851
INHIBITION
E2Fs link the control of G1/S and G2/M transcription
PubMed
15510213
MYO5A
Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A
PubMed
15510216
Translation
PAX3
GJB6
ACTIVATION
Translation
Heat Shock Protein 20 Interacting With Phosphorylated Akt Reduces Doxorubicin-Triggered Oxidative Stress and Cardiotoxicity
PubMed
18948619
Stat proteins and oncogenesis
PubMed
11994401
The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32
PubMed
8900201
HSP90-CDC37.complex
HSP90-CDC37 chaperone complex
NGF
EPOR_inactive
DLX5_DNA
INHIBITION
ACTIVATION
GFI1
INHIBITION
MAP2K2
INHIBITION
COL1A1_RNA
Translation
CASP8_inactive
INHIBITION
Entrez Gene
3606
GSN
Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
PubMed
9381178
ESR1
CCL2_RNA
Progressive hearing loss in mice with a mutated vitamin D receptor gene
PubMed
18259074
LEF/TCF-BETA CATENIN.complex_inactive
MCL1
MYO7A
Entrez Gene
7076
CXCL2
CD40-mediated transcriptional regulation of the IL-6 gene in B lymphocytes: involvement of NF-kappa B, AP-1, and C/EBP
PubMed
12626566
Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear
PubMed
16495313
MAPKAPK2_inactive
GFI1
DLX5
The JAK-STAT signaling pathway: input and output integration
PubMed
17312100
FOXI1_inactive
POU4F3
USH1C
Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse
PubMed
17055430
DACH2_DNA
Entrez Gene
2934
MAP2
BCL2L1
microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma
PubMed
18483236
COL1A2
MKK3/6.family_inactive
Mxi2 promotes stimulus-independent ERK nuclear translocation
PubMed
17255949
ALC.complex
ankle-link molecular complex (ALC)
TFRC_RNA
INHIBITION
Entrez Gene
1499
PAX8
Estradiol differentially modulates the exocytotic proteins SNAP-25 and munc-18 in pituitary gonadotrophs
PubMed
17293448
CCL2_DNA
Entrez Gene
2056
CTNNB1
Entrez Gene
2057
BMF
APC_RNA
Human Rad51 amino acid residues required for Rad52 binding
PubMed
10448035
CDH23
GADD45B_RNA
Translation
Heat shock proteins: essential proteins for apoptosis regulation
PubMed
18266962
Entrez Gene
7849
ACTIVATION
Translation
BID
Entrez Gene
2064
Entrez Gene
2066
Entrez Gene
2065
A distinct element involved in lipopolysaccharide activation of the tumor necrosis factor-alpha promoter in monocytes
PubMed
10954918
Exogenous nitric oxide stimulates cell proliferation via activation of a mitogen-activated protein kinase pathway in ovine fetoplacental artery endothelial cells
PubMed
16251502
E2F1-3.family_inactive
Entrez Gene
652
ATR
MIR150
AP-1_I.complex
AP-1 (JUN/:FOS)
CDKN1C
DUSP1
GSN_inactive
Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner
PubMed
9922454
EPO
ACTIVATION
NOTCH1_RNA
Translation
ACTIVATION
CSF1R_RNA
CDKN1C
INHIBITION
Recent developments in our understanding of how platelet-derived growth factor (PDGF) and its receptors contribute to proliferative vitreoretinopathy
PubMed
19931527
ACTIVATION
NOTCH1_DNA
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
PubMed
11369511
PAX6
LHX3
Manipulating cell cycle regulation in the mature cochlea
PubMed
17658230
ACTIVATION
NOS2
PCNA
Entrez Gene
7039
Entrez Gene
7037
INHIBITION
Entrez Gene
406899
ACTIVATION
RAF1
PhysicalInteraction [MYO7A -- USH2A ]
ACTA1_inactive
ATF2
PAX.family
TP53_inactive
EGF
ACTIVATION
Coordinated control of connexin 26 and connexin 30 at the regulatory and functional level in the inner ear
PubMed
19047647
Entrez Gene
2099
CASP1
Translation
FOS
INHIBITION
Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2
PubMed
8626767
The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4
PubMed
9463381
miR-29.family
BARHL1
ATOH1
ACTIVATION
GATA3
Entrez Gene
207
Entrez Gene
6347
Overview of cell death signaling pathways
PubMed
15725726
Entrez Gene
1432
Entrez Gene
5459
Entrez Gene
604
Entrez Gene
1436
IL18_DNA
Entrez Gene
114614
Entrez Gene
610
Peripheral myelin protein 22 is regulated post-transcriptionally by miRNA-29a
PubMed
19170179
FGF10_inactive
ACTIVATION
ACTIVATION
PTK2
Entrez Gene
6774
PhysicalInteraction [MYO7A -- USH1G ]
Entrez Gene
6772
EGR1
ERBB4
ATM
ACTIVATION
Entrez Gene
637
ACTIVATION
Entrez Gene
5075
Entrez Gene
5076
Entrez Gene
5077
Entrez Gene
5078
Entrez Gene
5079
Entrez Gene
641
ID2
NOTCH1
ACTIVATION
Translation
INHIBITION
ACTIVATION
Constitutive activation of nuclear factor kappaB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer
PubMed
12727841
Entrez Gene
5083
Entrez Gene
627
COL1A1_inactive
Entrez Gene
5080
Entrez Gene
7421
ATOH1_RNA
DUSP1
CREBBP
HSPB1
Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome
PubMed
11734542
INHIBITION
ATOH1
TP53
Mechanism in the sequential control of cell morphology and S phase entry by epidermal growth factor involves distinct MEK/ERK activations
PubMed
11251083
CASP1_DNA
TGFA
ACTIVATION
VDR_RNA
Entrez Gene
5013
NOS2_RNA
Cholesterol enrichment upregulates intercellular adhesion molecule-1 in human vascular endothelial cells
PubMed
11786300
FGF3
SCF.complex
SCF-FBXW7
CD19
FGF3_inactive
Entrez Gene
574034
POU4F3
HIF-1.complex
Hypoxia-inducible factor-1
Casein kinase 2 inhibition decreases hypoxia-inducible factor-1 activity under hypoxia through elevated p53 protein level
PubMed
16882692
Entrez Gene
90427
COL1A2
ACTIVATION
WNT1
WNT1
MIR106A_RNA
TDG
PAX8
Translation
ACTIVATION
OTOF
FGF20_inactive
INHIBITION
PDCD1_RNA
MIR29B1
GATA3_RNA
ACTIVATION
CD19_DNA
RHOA
DACH2
Myc antagonizes Ras-mediated growth arrest in leukemia cells through the inhibition of the Ras-ERK-p21Cip1 pathway
PubMed
15528212
DLX5
ACTIVATION
INHIBITION
INHIBITION
Entrez Gene
4780
X-linked IAP is a direct inhibitor of cell-death proteases
PubMed
9230442
ID1
PCDH15
Translation
JAG1_inactive
NRG1
ACTIVATION
Translation
Translation
INHIBITION
ACTIVATION
Entrez Gene
182
CREBBP
Translation
MicroRNAs 221 and 222 bypass quiescence and compromise cell survival
PubMed
18413744
YY1
PhysicalInteraction [CAMK2A -- MYO7A ]
IL6
HCN2_inactive
DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death
PubMed
18806755
Eya1 regulates the growth of otic epithelium and interacts with Pax2 during the development of all sensory areas in the inner ear
PubMed
16916509
MAP2
Dynamic FoxO transcription factors
PubMed
17646672
CCL2
Translation
ID3
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
PubMed
9065401
TIMP1_inactive
Entrez Gene
117154
Caspase-mediated cleavage of focal adhesion kinase pp125FAK and disassembly of focal adhesions in human endothelial cell apoptosis
PubMed
9463408
GnRH activates ERK1/2 leading to the induction of c-fos and LHbeta protein expression in LbetaT2 cells
PubMed
11875099
ACTIVATION
HMOX1_DNA
Translation
CDH23
Translation
POU4F3_RNA
MYC_RNA
SKP2
Translation
ACTIVATION
CASP7
ACTIVATION
Usher syndrome type I G (USH1G) is caused by mutations in the gene encoding SANS, a protein that associates with the USH1C protein, harmonin
PubMed
12588794
NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma
PubMed
18977326
OTX1
VDR
Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression
PubMed
12789342
TGFA
Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis
PubMed
11483855
Lhx3, a LIM domain transcription factor, is regulated by Pou4f3 in the auditory but not in the vestibular system
PubMed
17331196
Entrez Gene
340784
RHOA
MYB
Entrez Gene
142
ACTIVATION
EDN1
ACTIVATION
Entrez Gene
2597
TNF
ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses
PubMed
12919958
BLM_inactive
TUB
ID3_DNA
ACTG1
CD95 (Fas)-induced caspase-mediated proteolysis of NF-kappaB
PubMed
9500443
Delineation of the caspase-9 signaling cascade
PubMed
17899380
Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases
PubMed
8939914
ACTIVATION
BID_inactive
INHIBITION
MAPK1_DNA
CASP1
ACTIVATION
f-actin.complex_inactive
HIF-1.complex_inactive
MAP2K3
Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death
PubMed
11447297
IL6
GHR
Early Growth Response-1 gene mediates up-regulation of epidermal growth factor receptor expression during hypoxia.
PubMed
11830539
CDKN1A
CASP3
Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016
PubMed
14737100
ACTIVATION
MAGI1
Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK
PubMed
12792650
Translation
ACTIVATION
Cell death by mitotic catastrophe: a molecular definition
PubMed
15077146
RAD51_inactive
Translation
ACTIVATION
Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family
PubMed
11390657
Translation
MAPK1_inactive
MAGI-1, a candidate stereociliary scaffolding protein, associates with the tip-link component cadherin 23
PubMed
18971469
MAPK3
NFE2L2
INHIBITION
FGF20
INHIBITION
BLM
Epidermal growth factor receptor: mechanisms of activation and signalling
PubMed
12648464
The Bcl2 family: regulators of the cellular life-or-death switch
PubMed
12209154
Direct p53 Transcriptional Repression: In Vivo Analysis of CCAAT-Containing G2/M Promoters
PubMed
15831478
Functional interaction of beta-catenin with the transcription factor LEF-1
PubMed
8757136
Translation
ACTIVATION
E2F-dependent induction of p14ARF during cell cycle re-entry in human T cells
PubMed
17912037
ACTIVATION
IL6_DNA
IGF2_RNA
TNF-alpha and H2O2 induce IL-18 and IL-18R beta expression in cardiomyocytes via NF-kappa B activation
PubMed
12684057
Entrez Gene
1843
STAT1 as a key modulator of cell death
PubMed
17085014
Translation
Myo.family
Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR
PubMed
17558410
Nuclear Stabilization of {beta}-catenin and Inactivation of Glycogen Synthase Kinase-3{beta} by Gonadotropin-Releasing Hormone: Targeting Wnt Signaling in the Pituitary Gonadotrope
PubMed
17717075
Cytokine-mediated transcriptional induction of the human inducible nitric oxide synthase gene requires both activator protein 1 and nuclear factor kappaB-binding sites
PubMed
9712833
CD44
TFRC_inactive
PTK2_RNA
PhysicalInteraction [EGFR -- ERBB2 ]
Structural requirements for PAK activation by Rac GTPases
PubMed
9705280
Entrez Gene
3162
INHIBITION
CycD-Cdk4.complex
CyclinD-CDK4
FOXI1
Thymocyte development in early growth response gene 1-deficient mice
PubMed
12165491
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
PubMed
12191486
NF-Y.complex
NF-Y (trimer) transcription factor
Entrez Gene
1026
Entrez Gene
58
Peroxynitrite induces GADD34, 45, and 153 VIA p38 MAPK in human neuroblastoma SH-SY5Y cells
PubMed
11163539
Entrez Gene
1027
Entrez Gene
1028
Entrez Gene
1029
LHX3
HMX3_inactive
GNRH1
INHIBITION
ID3_RNA
FOS_inactive
CASP3_inactive
BDNF_inactive
The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism
PubMed
11579085
ID1
Entrez Gene
9261
EGFR_RNA
MAPK14
Gata3 is required for early morphogenesis and Fgf10 expression during otic development
PubMed
16806848
INHIBITION
USH2A
Translation
ACTIVATION
Rb regulates fate choice and lineage commitment in vivo
PubMed
20686481
Transcription profiling of inner ears from Pou4f3(ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene
PubMed
15254021
ACTIVATION
Characterization of the antiapoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ovary
PubMed
10579309
CD19_RNA
GSN
BAD
INHIBITION
Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence
PubMed
11971971
EGF
INHIBITION
INHIBITION
Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode
PubMed
18495817
INHIBITION
Entrez Gene
2920
INHIBITION
ACTIVATION
TIMP1
STAT1
ACTIVATION
INHIBITION
PTK2_inactive
Rac1-MKK3-p38-MAPKAPK2 pathway promotes urokinase plasminogen activator mRNA stability in invasive breast cancer cells
PubMed
12377770
The developmental genetics of auditory hair cells
PubMed
15358736
Critical roles for c-Myb in hematopoietic progenitor cells
PubMed
18585056
p53 modulates homologous recombination by transcriptional regulation of the RAD51 gene
PubMed
16322760
MIR433
A chaperone-dependent GSK3beta transitional intermediate mediates activation-loop autophosphorylation
PubMed
17188038
Translation
Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia
PubMed
18652815
MIR17
JAG1_RNA
HES5_DNA
Connecting proliferation and apoptosis in development and disease
PubMed
15459661
ACTIVATION
ACTIVATION
MIR29A
INHIBITION
MYOG
ACTIVATION
ATOH1_DNA
NF-Y mediates the transcriptional inhibition of the cyclin B1, cyclin B2, and cdc25C promoters upon induced G2 arrest
PubMed
11096075
INHIBITION
INHIBITION
MYO7A_inactive
PMP22
TNF_RNA
RB1_RNA
NTF3_DNA
Translation
Entrez Gene
2138
CASP1_RNA
USH2A
MIR106A_DNA
Entrez Gene
9223
FGFR.family
PROX1
PDGFA
JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis
PubMed
14737178
Cytokine regulation of interleukin-6 gene expression in astrocytes involves activation of an NF-kappa B-like nuclear protein
PubMed
1644898
INHIBITION
mir-17.family
Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit
PubMed
16990795
BCL2L1_inactive
CD79A_DNA
CDC42_inactive
ACTIVATION_UNKMECH
ACTIVATION
JAG1
ACTIVATION
ACTIVATION
BID_RNA
COL1A2_RNA
DFNB31
FBXO2
The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites
PubMed
11927604
ELK1_inactive
CASP3
VDR_DNA
Regulation of IL-18 production by IFN gamma and PGE2 in mouse microglial cells: involvement of NF-kB pathway in the regulatory processes
PubMed
11377701
ACTIVATION
EDN1
Nuclear caspase-3 and caspase-7 activation, and poly(ADP-ribose) polymerase cleavage are early events in camptothecin-induced apoptosis
PubMed
16374543
In vitro selection and characterization of Bcl-X(L)-binding proteins from a mix of tissue-specific mRNA display libraries
PubMed
11283018
TP53_DNA
ACTIVATION
IFN regulatory factor-2 regulates macrophage apoptosis through a STAT1/3- and caspase-1-dependent mechanism
PubMed
17339457
INHIBITION
Entrez Gene
5111
FOXI1
PAX9
Translation
Entrez Gene
1387
Entrez Gene
1386
HSP90AA1
f-actin.complex
filamentous actin
ERK1b, a 46-kDa ERK isoform that is differentially regulated by MEK
PubMed
10748187
Selective cochlear degeneration in mice lacking the F-box protein, Fbx2, a glycoprotein-specific ubiquitin ligase subunit
PubMed
17494702
DAP-kinase-mediated morphological changes are localization dependent and involve myosin-II phosphorylation
PubMed
15002035
DACH1
Translation
CDKN1B
IFN-gamma up-regulates IL-18 gene expression via IFN consensus sequence-binding protein and activator protein-1 elements in macrophages
PubMed
10975835
ACTIVATION
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
PubMed
9346240
MAF_DNA
CD44_RNA
Entrez Gene
64072
ACTIVATION
GNRHR_RNA
Translation
ACTIVATION
Entrez Gene
26281
focal adhesion.complex
focal adhesion complex
PMP22
Entrez Gene
388585
Identification of dynamic proteome changes upon ligand activation of Trk-receptors using two-dimensional fluorescence difference gel electrophoresis and mass spectrometry
PubMed
15654083
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
PubMed
15694340
ACTIVATION
Entrez Gene
406982
MAPK14_DNA
MIR20A
Recruitment of a repressosome complex at the growth hormone receptor promoter and its potential role in diabetic nephropathy
PubMed
12529387
Cytoplasmic p21 is a potential predictor for cisplatin sensitivity in ovarian cancer
PubMed
21933447
Thrombopoietin regulates IEX-1 gene expression through ERK-induced AML1 phosphorylation
PubMed
16368886
Translation
OTX1
CAMK2A
CASP7
GADD45A_RNA
SNAP25
ACTIVATION
JAK2
Translation
ACTIVATION
STAT3
ACTIVATION
Translation
MIR320A
CDKN2A
MAP2K1
JAK2
ACTIVATION
CDK1
Translation
The cochlear F-box protein OCP1 associates with OCP2 and connexin 26
PubMed
15109709
ACTIVATION
Regulation of the gene encoding the monocyte chemoattractant protein 1 (MCP-1) in the mouse and rat brain in response to circulating LPS and proinflammatory cytokines
PubMed
11343293
SPARC_RNA
Entrez Gene
26232
GJB6
[W206R]-procaspase 3: an inactivatable substrate for caspase 8
PubMed
11437602
CASP9_inactive
BACE1
Entrez Gene
7157
ACTIVATION
ACTIVATION
mir-101.family
RUNX1_inactive
Entrez Gene
51701
ACTIVATION
Transcriptional regulation of the PCNA promoter by p53
PubMed
7915517
EGFR
ACTIVATION
INHIBITION
ERbBs.family
Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases
PubMed
8226933
CASP8
EPOR
INHIBITION
ERBB4
ACTIVATION
ACTIVATION
CASP6_DNA
USH1G
ATM
MYC_DNA
JAK2/STAT3, not ERK1/2, mediates interleukin-6-induced activation of inducible nitric-oxide synthase and decrease in contractility of adult ventricular myocytes
PubMed
12595539
PIK3R1
COL1A1
ACTIVATION
Entrez Gene
1749
GFI1_DNA
BCL2L1
Differential regulation of Bax and Bak by anti-apoptotic Bcl-2 family proteins Bcl-B and Mcl-1
PubMed
18178565
PhysicalInteraction [DFNB31 -- USH2A ]
Glutathione-thiyl radical scavenging and transferase properties of human glutaredoxin (thioltransferase). Potential role in redox signal transduction
PubMed
12556467
EGFR_DNA
ACTIVATION
ACTIVATION
Translation
Reciprocal cross talk between gonadotropin-releasing hormone (GnRH) and prostaglandin receptors regulates GnRH receptor expression and differential gonadotropin secretion
PubMed
17138645
ACTIVATION
The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest
PubMed
11136975
ACTIVATION
CD79B
MAP2K1
BCL2_inactive
A single BIR domain of XIAP sufficient for inhibiting caspases
PubMed
9525868
RBPJ
ACTIVATION
SIX1
CASP7_inactive
Entrez Gene
355
ACTIVATION
SMAD4
FBXO2
ACTIVATION
MIR433
ACTIVATION
Entrez Gene
3586
FOXG1
Activation of ErbB2 by 2-methyl-1,4-naphthoquinone (menadione) in human keratinocytes: role of EGFR and protein tyrosine phosphatases
PubMed
16516204
PAX2_RNA
Entrez Gene
4616
Entrez Gene
367
Gelsolin superfamily proteins: key regulators of cellular functions
PubMed
15526166
Entrez Gene
5595
Entrez Gene
5594
INHIBITION
Translation
Entrez Gene
7545
MYO3A
KAT5_inactive
The c-myb Protooncogene and microRNA (miR)-15a comprise an active autoregulatory feedback loop in human hematopoietic cells
PubMed
18818396
Entrez Gene
6495
Thrombin activates the p21-activated kinase in pulmonary artery smooth muscle cells. Role in tissue factor expression
PubMed
15968404
DAPK1_DNA
INHIBITION
ACTIVATION
Entrez Gene
331
Entrez Gene
4609
Translation
DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation
PubMed
11146619
ACTIVATION
Analysis of receptor signaling pathways by mass spectrometry: identification of vav-2 as a substrate of the epidermal and platelet-derived growth factor receptors
PubMed
10618391
SIX1_inactive
NOS2
Spike DB
CEN:F-329904
ACTIVATION
ACTIVATION
ACTIVATION
c-fos regulates neuronal excitability and survival
PubMed
11925568
Entrez Gene
3569
PhysicalInteraction [ACTA1 -- MYO7A ]
LHX3_RNA
ACTIVATION
PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites
PubMed
18025084
ACTIVATION
PhysicalInteraction [MYO7A -- USH1C ]
Investigation of the proapoptotic BCL-2 family member bid on the crossroad of the DNA damage response and apoptosis
PubMed
18662573
Entrez Gene
4602
Enhancers and transcription factors controlling the inducibility of the tumor necrosis factor-alpha promoter in primary macrophages
PubMed
1715367
Transcriptional control of human p53-regulated genes
PubMed
18431400
BID_DNA
Entrez Gene
7528
CDKN1A_RNA
Regulation of tumor necrosis factor alpha promoter by human parvovirus B19 NS1 through activation of AP-1 and AP-2
PubMed
11991968
JAG1
HMX3
PARP1_inactive
Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis
PubMed
9323209
Pro-proliferative FoxM1 is a target of p53-mediated repression
PubMed
19749794
Casein kinase 2- and protein kinase A-regulated adenomatous polyposis coli and beta-catenin cellular localization is dependent on p38 MAPK
PubMed
15649893
ACTIVATION
ERK.family
ESR1
CK2.complex
Caseine Kinase 2
Regulation of DNA damage response pathways by the cullin-RING ubiquitin ligases
PubMed
19231300
Entrez Gene
5154
BACE1_inactive
MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA
PubMed
18794355
INHIBITION
Translation
Entrez Gene
324
ACTIVATION
Activation of interleukin-6 gene expression through the NF-kappa B transcription factor
PubMed
2183031
MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma
PubMed
18521080
PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation
PubMed
12876277
p38.family_inactive
GJB2_inactive
ACTIVATION
Translation
H2AFX
ACTIVATION
SMAD2
CDK1_DNA
Usher syndrome: animal models, retinal function of Usher proteins, and prospects for gene therapy
PubMed
17936325
ACTIVATION
BMP4_RNA
Entrez Gene
53904
Entrez Gene
4094
PAX2_DNA
Entrez Gene
51762
ACTIVATION
Entrez Gene
5133
Entrez Gene
4656
Regulation of c-myc expression by IFN-gamma through Stat1-dependent and -independent pathways
PubMed
10637230
NOS2_DNA
ACTIVATION
ATM-dependent phosphorylation of ATF2 is required for the DNA damage response
PubMed
15916964
Entrez Gene
5925
Entrez Gene
4087
ACTIVATION
Entrez Gene
4089
IL10_DNA
PROX1
Entrez Gene
3516
Entrez Gene
4647
Entrez Gene
4644
MAPK1
SOX2
Computer-assisted identification of cell cycle-related genes: new targets for E2F transcription factors.
PubMed
11491305
B-AgR.complex
B-cell Antigen Receptor
ACTIVATION
ACTIVATION
Entrez Gene
5629
ACTIVATION
Differential regulation of expression of the mammalian DNA repair genes by growth stimulation
PubMed
15467751
BMP4
SMAD2
The anaphase-promoting complex: a key factor in the regulation of cell cycle
PubMed
15678131
CXCL2
DACH1_RNA
GAPDH_RNA
KAT5
INHIBITION
GHR_DNA
MAPK3_inactive
BID
PhysicalInteraction [ATOH1 -- SKP2 ]
Translation
TP53
Gadd45a, a p53- and BRCA1-regulated stress protein, in cellular response to DNA damage
PubMed
15603758
Spike DB
ELK:F-000030
INHIBITION
ACTIVATION
ACTIVATION
CDKN1C_inactive
ACTIVATION
Entrez Gene
5606
intact:EBI-875451,intact:EBI-875494
PhysicalInteraction [EGFR -- ERBB3 ]
Entrez Gene
5608
Regulation of Raf-Akt Cross-talk
PubMed
12048182
ACTIVATION
CSF1R
PhysicalInteraction [PCDH15 -- USH1C ]
INHIBITION
Pro-caspase-3 is a major physiologic target of caspase-8
PubMed
9765224
ACTIVATION
NFkB.complex
Nuclear factor kappa-B
CASP1_inactive
Bradykinin induces interleukin-6 expression in astrocytes through activation of nuclear factor-kappaB
PubMed
10501190
ACTIVATION
BMF
ACTIVATION
IL10
CycB-Cdc2.complex_inactive
PP1.complex
PP1 (Protein Phosphatase 1)
A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members
PubMed
9111042
TRAIL and cancer therapy
PubMed
18329793
The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells
PubMed
15577913
Molecular biology of gonadotropin-releasing hormone (GnRH)-I, GnRH-II, and their receptors in humans
PubMed
15561800
DFNB31
PhysicalInteraction [CDH23 -- USH1C ]
NTF3
FGF1
A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM
PubMed
16141325
Translation
ID2
The transcription factor activator protein-1 is activated and interleukin-6 production is increased in interleukin-1beta-stimulated human enterocytes
PubMed
11028561
p21/CDKN1A mediates negative regulation of transcription by p53
PubMed
12748190
FOXO-binding partners: it takes two to tango
PubMed
18391971
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
PubMed
9390557
GAPDH_DNA
ERBB2
Entrez Gene
3091
ACTIVATION
Hsp90 and Cdc37 -- a chaperone cancer conspiracy
PubMed
15661534
HES5_RNA
Mutagenesis of the BH3 domain of BAX identifies residues critical for dimerization and killing
PubMed
9742125
ACTIVATION
ACTIVATION
ACTIVATION
CDK1_RNA
ACTIVATION
The genomic analysis of erythrocyte microRNA expression in sickle cell diseases
PubMed
18523662
BID regulation by p53 contributes to chemosensitivity
PubMed
12402042
ACTIVATION
Entrez Gene
5604
Entrez Gene
5605
Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation
PubMed
15531749
Entrez Gene
5893
INHIBITION
Entrez Gene
5894
GADD45B
BCL6
Foxos.family_inactive
PAX3
MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity
PubMed
19155302
Entrez Gene
3481
ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling
PubMed
17124492
GFI1_RNA
The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer
PubMed
12573436
INHIBITION
ACTIVATION
INHIBITION
Entrez Gene
3084
GATA3
Stress-induced inhibition of ERK1 and ERK2 by direct interaction with p38 MAP kinase
PubMed
11238443
COL1A1
ACTIVATION
Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM
PubMed
12034743
CSF1R_DNA
INHIBITION
Role of ERK and calcium in the hypoxia-induced activation of HIF-1
PubMed
12447987
ATR_RNA
Entrez Gene
7124
Entrez Gene
9381
ACTIVATION
PDCD1_DNA
MIR150
INHIBITION
Translation
Coordinate actions of calcium and protein kinase-C in the expression of primary response genes in pituitary gonadotrophs
PubMed
7518388
FGF.family
ACTIVATION
LEF/TCF-BETA CATENIN.complex
LEG/TCF-BETA CATENIN
ACTIVATION
Entrez Gene
3955
ACTIVATION
ACTIVATION
RAD52
EYA1_DNA
Translation
MAPK14
TFRC
ERBB3
CDK1
PhysicalInteraction [CDH23 -- MAGI1 ]
ACTIVATION
GHR_RNA
ACTIVATION
ACTIVATION
RUNX1
GJB2
ACTIVATION
EGR1_DNA
ACTIVATION
c-Myb is an evolutionary conserved miR-150 target and miR-150/c-Myb interaction is important for embryonic development
PubMed
18667440
p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y
PubMed
14586402
RAF1
INHIBITION
EDN1_RNA
Entrez Gene
6996
ACTIVATION
ACTIVATION
INHIBITION
ACTIVATION
MIR20A
TDG_inactive
GNRHR
ACTIVATION
Spike DB
TAU:F-329920
ACTIVATION
PhysicalInteraction [FBXO2 -- GJB2 ]
Identification of a novel p53-dependent activation pathway of STAT1 by antitumour genotoxic agents
PubMed
17992189
ACTIVATION
ACTIVATION
Regulation of p38 MAPK by MAPK kinases 3 and 6 in fibroblast-like synoviocytes
PubMed
15778394
ZIC1
Spike DB
TAU:F-329928
MIR15A
Spike DB
TAU:F-329927
Spike DB
TAU:F-329925
Spike DB
TAU:F-329924
Spike DB
TAU:F-329923
PCNA
MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression
PubMed
18212054
PhysicalInteraction [JAG1 -- NOTCH1 ]
ACTIVATION
ICAM1_RNA
OTX1_DNA
PAX2
Entrez Gene
3014
INHIBITION
BARHL1_DNA
EPO-EPOR.complex
EPO-EPOR
Spike DB
CEN:F-329884
NFkB.complex_RNA
Entrez Gene
2002
PAX9
NGFs.family
Conversion of Bcl-2 to a Bax-like death effector by caspases
PubMed
9395403
H2AFX
Pax6-Sox2.complex
Pax6-Sox2 complex
JAK2_inactive
Spike DB
TAU:F-329914
Spike DB
TAU:F-329913
Barhl1 regulatory sequences required for cell-specific gene expression and autoregulation in the inner ear and central nervous system
PubMed
18212062
PhysicalInteraction [DFNB31 -- MYO7A ]
EGR1_RNA
BAX_inactive
INHIBITION
CASP9
INHIBITION
Translation
YY1_inactive
IL18
BAX_DNA
PARP1
Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes
PubMed
18667412
PhysicalInteraction [BCL2 -- BMF ]
MIR155HG
nhibition of p38 MAPK by glucocorticoids via induction of MAPK phosphatase-1 enhances nontypeable Haemophilus influenzae-induced expression of toll-like receptor 2.
PubMed
12356755
Entrez Gene
10804
PhysicalInteraction [LHX3 -- POU4F3 ]
Poly(ADP-ribose) polymerase 1 promotes tumor cell survival by coactivating hypoxia-inducible factor-1-dependent gene expression
PubMed
18314489
Entrez Gene
406952
PAX3_inactive
RUNX1
JAG1_DNA
USH2A_inactive
ACTIVATION
FAS
Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo
PubMed
9915826
p21Cip1 gene expression is modulated by Egr1: a novel regulatory mechanism involved in the resveratrol antiproliferative effect
PubMed
12690110
Spike DB
TAU:F-329931
Spike DB
TAU:F-329932
Spike DB
TAU:F-329934
Entrez Gene
406948
ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation
PubMed
10781582
TP53_RNA
Pathological signaling via PDGFR{alpha} involves chronic activation of Akt and suppression of p53
PubMed
21357737
Entrez Gene
406942