Entrez Gene
7399
PhysicalInteraction [MYH9 -- MYO3A ]
NFKB1
Entrez Gene
4133
CDKN1A
INHIBITION
GFI1_inactive
BCL2
Entrez Gene
1387
GPR98
Entrez Gene
1080
Entrez Gene
1385
PubMed
14697198
Prediction of mammalian microRNA targets
f-actin.complex
filamentous actin
DAPK1
PubMed
15002035
DAP-kinase-mediated morphological changes are localization dependent and involve myosin-II phosphorylation
INHIBITION
SMAD5
CREB1
Entrez Gene
51168
MYC
PhysicalInteraction [GPR98 -- MYO7A ]
Entrez Gene
64072
Entrez Gene
406979
Entrez Gene
10083
Entrez Gene
65217
INHIBITION
ESPN
ACTIVATION
GFI1
ATF4
AKT1
PubMed
15590698
Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly
CAD_inactive
ACTIVATION
ACTIVATION
GSN
INHIBITION
MIR19A
PubMed
15465029
Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity
PhysicalInteraction [GFI1 -- HDAC1 ]
MYO7A
TERT
PubMed
17050716
Stereociliary myosin-1c receptors are sensitive to calcium chelation and absent from cadherin 23 mutant mice
CAMK2A
GFI1
ACTIVATION
POU4F3
Entrez Gene
2745
USH1C
ACTIVATION
PubMed
16206170
Balanced levels of Espin are critical for stereociliary growth and length maintenance
Entrez Gene
406996
Entrez Gene
79784
Entrez Gene
2934
MAP2
Entrez Gene
406991
BCL2L1
ACTIVATION
PhysicalInteraction [MAP2 -- MYO7A ]
PhysicalInteraction [MEN1 -- Complex NFkB {Family NFkB_sub_II {RELA}} ]
HCN4
PubMed
16007092
Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3
INHIBITION
PubMed
16540633
The phosphoinositide 3-kinase/Akt1/Par-4 axis: a cancer-selective therapeutic target
Entrez Gene
8328
NTF3_RNA
PubMed
11171103
Myosin VIIA is specifically associated with calmodulin and microtubule-associated protein-2B (MAP-2B)
NFKB1
Translation
Translation
PubMed
15805470
Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4
CDH23
PubMed
15037754
The unique insert in myosin VI is a structural calcium-calmodulin binding site
MEN1
INHIBITION
INHIBITION
MPDZ
Entrez Gene
7157
BDNF
Actin.family
INHIBITION
PubMed
11313698
DAP-kinase: from functional gene cloning to establishment of its role in apoptosis and cancer
MEN1
Entrez Gene
790
PubMed
11080149
Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex
intact:EBI-1064920,intact:EBI-1064920
PhysicalInteraction [GIPC1 -- MYO6 ]
CDKN1C
PubMed
16533812
Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer
Entrez Gene
4221
GSN_inactive
BAX
PubMed
17681183
MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
CDKN1C
FUS_RNA
PubMed
12804776
PTEN modulates insulin-like growth factor II (IGF-II)-mediated signaling; the protein phosphatase activity of PTEN downregulates IGF-II expression in hepatoma cells
CAMK2A
USH1G
CALM2
LHX3
GFI1_DNA
ATF4
BCL2L1
PhysicalInteraction [EPCAM -- MYO3A ]
PhysicalInteraction [DFNB31 -- USH2A ]
MYO15A_inactive
ACTIVATION
PhysicalInteraction [MYO7A -- USH2A ]
PubMed
12556467
Glutathione-thiyl radical scavenging and transferase properties of human glutaredoxin (thioltransferase). Potential role in redox signal transduction
ACTA1_inactive
SPRY2
PubMed
17476304
Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression
Entrez Gene
10755
PhysicalInteraction [GFI1B -- HDAC2 ]
Translation
MYO3A
Homo sapiens
ACTA1
BCL2_inactive
CFTR
Entrez Gene
4627
Entrez Gene
4628
Entrez Gene
4072
Entrez Gene
1639
Spike DB
TAU:F-000011
Entrez Gene
815
ATOH1
LHX3_DNA
Entrez Gene
207
PubMed
18973575
Ablation of Cx47 in transgenic mice leads to the loss of MUPP1, ZONAB and multiple connexins at oligodendrocyte-astrocyte gap junctions
HCN4
PubMed
15725726
Overview of cell death signaling pathways
Entrez Gene
5459
PubMed
15526166
Gelsolin superfamily proteins: key regulators of cellular functions
Entrez Gene
801
Entrez Gene
7401
Entrez Gene
805
Entrez Gene
610
PubMed
17145710
IntAct--open source resource for molecular interaction data
PubMed
16862555
Expression of Myh9 in the mammalian cochlea: localization within the stereocilia
FUS_DNA
MYO3A
INHIBITION
PubMed
19287378
Myosin IIIa boosts elongation of stereocilia by transporting espin 1 to the plus ends of actin filaments
PhysicalInteraction [MYO7A -- USH1G ]
BAX_RNA
EGR1
MYH9
ACTIVATION
PubMed
14729949
Suppression of PTEN expression by NF-kappa B prevents apoptosis
PubMed
19043405
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
Entrez Gene
4609
MYH10
PhysicalInteraction [FUS -- MYO6 ]
SP1
Translation
DAPk localizes to the actin cytoskeleton by immunostaining and cell fractionation
PhysicalInteraction [DAPK1 -- Complex f-actin {} ]
Entrez Gene
836
ACTIVATION
PTPN11
BDNF_DNA
PubMed
11242034
Mammalian MAP kinase signalling cascades
G6PD_inactive
PhysicalInteraction [ACTA1 -- MYO7A ]
LHX3_RNA
EPCAM
ACTIVATION
Entrez Gene
627
PhysicalInteraction [ESPN -- MYO15A ]
HDAC3_inactive
PhysicalInteraction [MYO7A -- USH1C ]
MYO1C
Entrez Gene
1612
CALM1
ATOH1_RNA
PubMed
18431400
Transcriptional control of human p53-regulated genes
CDKN1A_RNA
CREBBP
Entrez Gene
6667
MYH10
PubMed
9323209
Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis
Entrez Gene
5970
ATOH1
NFKB1_RNA
TP53
TERT
DCTN1
ERK.family
CK2.complex
Caseine Kinase 2
MHC (nonmuscle).family
Entrez Gene
2672
Entrez Gene
2670
PubMed
12881425
Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation
SPRY2
Entrez Gene
596
PubMed
15150273
Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2
MYO15A
Entrez Gene
598
GPR98
Spike
Translation
MAGI1
AKT1_inactive
INHIBITION
PubMed
12080385
USH3A transcripts encode clarin-1, a four-transmembrane-domain protein with a possible role in sensory synapses
POU4F3
ACTIVATION
MYO7A
GFI1B
PhysicalInteraction [ESPN -- MYO3A ]
mir-1.family
ACTIVATION
ACTIVATION
Entrez Gene
468
PubMed
17936325
Usher syndrome: animal models, retinal function of Usher proteins, and prospects for gene therapy
PhysicalInteraction [CLRN1 -- MYO7A ]
Entrez Gene
53904
G6PD
NFkB_sub_II.family
PhysicalInteraction [MEN1 -- SMAD5 ]
Translation
INHIBITION
HDAC3
PubMed
9930654
Caspase-3-induced gelsolin fragmentation contributes to actin cytoskeletal collapse, nucleolysis, and apoptosis of vascular smooth muscle cells exposed to proinflammatory cytokines
PhysicalInteraction [GFI1 -- HDAC2 ]
TERT_RNA
PhysicalInteraction [HDAC1 -- MEN1 ]
ACTIVATION
CALM1
CLRN1
Entrez Gene
474
Entrez Gene
4090
Entrez Gene
4790
EGR1
Entrez Gene
25861
SP1_inactive
Entrez Gene
4908
PROX1
PubMed
18508928
MicroRNA-21 Targets Sprouty2 and Promotes Cellular Outgrowths
PubMed
12837246
Multiple tumor suppressor pathways negatively regulate telomerase
AKT1
CALM2
PubMed
16997566
Menin and its interacting proteins: elucidation of menin function
ACTIVATION
PhysicalInteraction [CALM1 -- MYO1C ]
PhysicalInteraction [MEN1 -- NFKB1 ]
PubMed
20416459
In vitro expression and characterization of MYH9 mutant alleles linked to hereditary hearing loss
Entrez Gene
581
Entrez Gene
4647
Entrez Gene
5728
DAPK1
Entrez Gene
4646
Entrez Gene
4641
MYC
RELA
MIR19A
PTEN_inactive
GAPDH_inactive
PCDH15
Entrez Gene
5629
Entrez Gene
2539
PubMed
10224060
Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit
PubMed
18458081
Downregulation of MIRNA-1/MIRNA-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart
PubMed
17353931
Large-scale mapping of human protein-protein interactions by mass spectrometry
PubMed
12927282
Expression of caspase-activated deoxyribonuclease (CAD) and caspase 3 (CPP32) in the cochlea of cisplatin (CDDP)-treated guinea pigs
CREBBP
HDAC1
CREB1
MIR21
CDKN1A_DNA
PhysicalInteraction [CAMK2A -- MYO7A ]
PubMed
19906824
microRNA 21: response to hormonal therapies and regulatory function in leiomyoma, transformed leiomyoma and leiomyosarcoma cells
HCN2_inactive
PubMed
16301217
Usherin, the defective protein in Usher syndrome type IIA, is likely to be a component of interstereocilia ankle links in the inner ear sensory cells
NOLC1
Entrez Gene
5781
MAP2
Entrez Gene
84059
USH1C
Translation
TP53
Spike DB
ELK:F-000030
PubMed
20730097
Conserved and distinct modes of CREB/ATF transcription factor regulation by PP2A/B56gamma and genotoxic stress
PubMed
19558455
A protein-protein interaction of stress-responsive myosin VI endowed to inhibit neural progenitor self-replication with RNA binding protein, TLS, in murine hippocampus
GLRX
CDKN1C_inactive
PhysicalInteraction [FUS -- MYO3A ]
Entrez Gene
8841
CAD
PubMed
9988278
Direct activation of TERT transcription by c-MYC
PhysicalInteraction [PCDH15 -- USH1C ]
PTEN_DNA
INHIBITION
NFkB.complex
Nuclear factor kappa-B
GFI1B
Translation
Translation
CDH23
PI3K.complex
Class I phosphoinositide-3-kinase
Entrez Gene
124590
PubMed
11123304
Multiple signals required for cyclic AMP-responsive element binding protein (CREB) binding protein interaction induced by CD3/CD28 costimulation
myosin II.complex
myosin II
PhysicalInteraction [MEN1 -- RELA ]
MYH14
USH1G
POU4F3_RNA
GFAP
PhysicalInteraction [USH1C -- USH1G ]
PhysicalInteraction [GFI1B -- HDAC1 ]
MYO1C
DAB2
DFNB31
PhysicalInteraction [CDH23 -- USH1C ]
MIR21
ACTIVATION
ACTIVATION
PhysicalInteraction [USH2A -- VEZT ]
MIR214
Spike DB
WSC:F-000021
PubMed
12588794
Usher syndrome type I G (USH1G) is caused by mutations in the gene encoding SANS, a protein that associates with the USH1C protein, harmonin
NTF3
PubMed
12384981
Regulation of life and death by the zinc finger transcription factor Egr-1
TERT_DNA
PubMed
11526476
The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation
ACTIVATION
PubMed
17331196
Lhx3, a LIM domain transcription factor, is regulated by Pou4f3 in the auditory but not in the vestibular system
INHIBITION
PubMed
16713569
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
PhysicalInteraction [DCTN1 -- MYO3A ]
PubMed
9118961
DAP-kinase is a Ca2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity
INHIBITION
GAPDH
INHIBITION
GFAP
PubMed
15184909
Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas
Translation
intact:EBI-1136111,intact:EBI-1137776,intact:EBI-1139313,intact:EBI-1140373,intact:EBI-1141531,intact:EBI-1144664,intact:EBI-1148514
PhysicalInteraction [MEN1 -- MYH9 ]
myosin II.complex_inactive
ACTIVATION
PubMed
18471544
Cellular and molecular mechanisms of liver injury
PhysicalInteraction [GFI1 -- HDAC3 ]
BDNF
DAPK1_inactive
Entrez Gene
2597
Entrez Gene
1601
Translation
PubMed
18160714
Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia
HCN2
PubMed
9660950
Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300
ACTA1
PubMed
1740105
The characterization of the promoter of the gene encoding the p50 subunit of NF-kappa B indicates that it participates in its own regulation
PubMed
12874834
Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism
VEZT
SP1
BAX
INHIBITION
INHIBITION
NFKB1_DNA
BDNF_RNA
PubMed
17619105
Whirler mutant hair cells have less severe pathology than shaker 2 or double mutants
intact:EBI-1171098
PhysicalInteraction [CFTR -- EPCAM ]
Spike DB
TAU:F-000005
PhysicalInteraction [CREB1 -- CREBBP ]
f-actin.complex_inactive
DAB2
GFI1_RNA
SPRY1_inactive
CLRN1
PhysicalInteraction [DAB2 -- MYO6 ]
CDKN1A
CASP3
HDAC1
SPRY2_inactive
ACTIVATION
MAGI1
HCN4_inactive
MYH14
Entrez Gene
8022
MPDZ
CK2.complex_inactive
PhysicalInteraction [MYO7A -- VEZT ]
GAPDH
ACTIVATION
PubMed
18971469
MAGI-1, a candidate stereociliary scaffolding protein, associates with the tip-link component cadherin 23
PubMed
15654330
Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia
PubMed
17932487
Interaction of tau protein with the dynactin complex
PubMed
18602179
GFAP aggregates in the cochlear nerve increase the noise vulnerability of sensory cells in the organ of Corti in the murine model of Alexander disease
INHIBITION
GPCR.family
PubMed
14508515
Menin, a tumor suppressor, associates with nonmuscle myosin II-A heavy chain
INHIBITION
PubMed
16169070
A human protein-protein interaction network: a resource for annotating the proteome
PubMed
11533489
Duration of nuclear NF-kappaB action regulated by reversible acetylation
MIR214
GLRX
ACTIVATION
taxonomy
9606
HDAC2
Entrez Gene
83715
PhysicalInteraction [DFNB31 -- MYO15A ]
SPRY1
mir-133.family
RELA
Entrez Gene
7015
Myo.family
INHIBITION
PhysicalInteraction [MPDZ -- MYO3A ]
ACTIVATION
PubMed
11906161
DOC-2/DAB2 is the binding partner of myosin VI
HDAC3
MYO15A
Entrez Gene
10252
Entrez Gene
1026
Entrez Gene
58
Entrez Gene
3066
Entrez Gene
10253
Entrez Gene
1028
Entrez Gene
3065
LHX3
PTEN_RNA
NFKB1_inactive
PTEN
PhysicalInteraction [CDH23 -- MAGI1 ]
MYH9
BDNF_inactive
CFTR
SMAD5
ACTIVATION
NFkB.complex_inactive
USH2A
G6PD
PhysicalInteraction [CALM2 -- MYO6 ]
NOLC1
EPCAM
PhysicalInteraction [CAD -- MYO3A ]
HCN2
PubMed
15254021
Transcription profiling of inner ears from Pou4f3(ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene
DCTN1
GSN
PubMed
11967127
Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton
PCDH15
INHIBITION
INHIBITION
ACTIVATION
PhysicalInteraction [GFAP -- MYO3A ]
PubMed
17187061
Myosin VI targeting to clathrin-coated structures and dimerization is mediated by binding to Disabled-2 and PtdIns(4,5)P2
CREB1_inactive
PhysicalInteraction [CREBBP -- RELA ]
Entrez Gene
10021
FUS
MYO6
Spike DB
TAU:F-329920
INHIBITION
POU4F3_DNA
CAD
PTEN
INHIBITION
ACTIVATION
VEZT
ACTIVATION
Translation
PubMed
17567809
Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning
Spike DB
TAU:F-329925
ESPN
MYO6
PubMed
18241676
NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK
ACTIVATION
GIPC1
PubMed
18652815
Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia
BCL2
PubMed
15590703
Interactions in the network of Usher syndrome type 1 proteins
ATOH1_DNA
PCDH15_inactive
DFNB31_inactive
RELA_inactive
Entrez Gene
55591
MYO7A_inactive
INHIBITION
Entrez Gene
8777
PubMed
17038328
Protein kinase CK2 is inhibited by human nucleolar phosphoprotein p140 in an inositol hexakisphosphate-dependent manner
PhysicalInteraction [DFNB31 -- MYO7A ]
FUS
ACTIVATION
PhysicalInteraction [CDH23 -- MYO1C ]
PubMed
18199536
MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN
NTF3_DNA
TERT_inactive
NTF3
PubMed
16481439
Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells
BAX_DNA
USH2A
INHIBITION
Entrez Gene
9221
Entrez Gene
9223
PROX1
Entrez Gene
2521
ACTIVATION
intact:EBI-734105
PhysicalInteraction [CALM1 -- MYO6 ]
BCL2L1_inactive
Entrez Gene
1958
USH2A_inactive
PKA (PRKA).complex
Protein kinase, cAMP-dependent
PubMed
19737086
Nuclear redox signalling
PTPN11
HDAC2
PI3K.complex_inactive
INHIBITION
Spike DB
TAU:F-329932
Spike DB
TAU:F-329934
SPRY1
PubMed
143236
Nonmuscle contractile proteins: the role of actin and myosin in cell motility and shape determination
DFNB31
INHIBITION
VEZT_inactive
GIPC1
CASP3
PhysicalInteraction [GFI1B -- HDAC3 ]