BMP4
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#652

http://www.ncbi.nlm.nih.gov/#7471
type: UnificationXref
db: Entrez Gene
id: 7471

http://www.ncbi.nlm.nih.gov/#8650
type: UnificationXref
db: Entrez Gene
id: 8650

.SIX1.PROMOTES.PAX2.
type: TemplateReactionRegulation
controller: SIX1
data source: Spike
controlled: Transcription.Regulation.P.SIX1.PAX2
xref: 17035528
control type: ACTIVATION

Translation
type: MolecularInteraction
participant: IL10
participant: IL10_RNA

FOXI1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2299

CDKN1A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1026

12614353
type: PublicationXref
db: PubMed
title: The Ras/MAPK cascade and the control of positive selection
id: 12614353

http://www.ncbi.nlm.nih.gov/#2625
type: UnificationXref
db: Entrez Gene
id: 2625

LFNG
type: Protein
entity reference: LFNG

14697198
type: PublicationXref
db: PubMed
title: Prediction of mammalian microRNA targets
id: 14697198

.SIX1.PROMOTES.GATA3.
type: Catalysis
controller: SIX1
control type: ACTIVATION
data source: Spike
controlled: Dephosphorylation.P.SIX1.GATA3
xref: 12874121

17494702
type: PublicationXref
db: PubMed
title: Selective cochlear degeneration in mice lacking the F-box protein, Fbx2, a glycoprotein-specific ubiquitin ligase subunit
id: 17494702

EYA1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2138

XPO6_inactive
type: Protein
entity reference: XPO6

Translation
type: MolecularInteraction
participant: JAG1_RNA
participant: JAG1_inactive

DACH1
type: Protein
entity reference: DACH1

20972443
type: PublicationXref
db: PubMed
title: Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes
id: 20972443

Translation
type: MolecularInteraction
participant: NOS2
participant: NOS2_RNA

CDKN1B
type: Protein
entity reference: CDKN1B

.Complex.AP.1 I....PROMOTES.CXCL2.
type: TemplateReactionRegulation
controller: AP-1_I.complex
data source: Spike
controlled: Transcription.Regulation.P.AP.1 I.CXCL2
xref: 14597166
control type: ACTIVATION

MIR1-2
type: Protein
entity reference: MIR1-2

19251936
type: PublicationXref
db: PubMed
title: Fra-1 negatively regulates lipopolysaccharide-mediated inflammatory responses
id: 19251936

11175815
type: PublicationXref
db: PubMed
title: Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade
id: 11175815

CD44_RNA
type: RnaRegion
entity reference: CD44

.Family.mir.1..MIR1.1,.MIR1.2..INHIBITS.BDNF.
type: Catalysis
controller: mir-1.family
control type: INHIBITION
data source: Spike
controlled: N/A.I.mir.1.BDNF
xref: 14697198

DLX5_DNA
type: DnaRegion
entity reference: DLX5

SPARC
type: Protein
entity reference: SPARC

GFI1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2672

Translation
type: MolecularInteraction
participant: PTGS2_RNA
participant: PTGS2

http://www.ncbi.nlm.nih.gov/#388585
type: UnificationXref
db: Entrez Gene
id: 388585

Translation
type: MolecularInteraction
participant: OTX1_RNA
participant: OTX1

HES1_inactive
type: Protein
entity reference: HES1

.Complex.AP.1 I....PROMOTES.PTGS2.
type: TemplateReactionRegulation
controller: AP-1_I.complex
data source: Spike
controlled: Transcription.Regulation.P.AP.1 I.PTGS2
xref: 11292836
xref: 12068008
control type: ACTIVATION

.SIX1.PROMOTES.HMX3.
type: Catalysis
controller: SIX1
control type: ACTIVATION
data source: Spike
controlled: Dephosphorylation.P.SIX1.HMX3
xref: 12874121

RBPJ
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3516

CCL2_RNA
type: RnaRegion
entity reference: CCL2

15465029
type: PublicationXref
db: PubMed
title: Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity
id: 15465029

OTX1
type: Protein
entity reference: OTX1

CXCL2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2920

16495313
type: PublicationXref
db: PubMed
title: Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear
id: 16495313

12626566
type: PublicationXref
db: PubMed
title: CD40-mediated transcriptional regulation of the IL-6 gene in B lymphocytes: involvement of NF-kappa B, AP-1, and C/EBP
id: 12626566

GFI1
type: Protein
entity reference: GFI1

BMP4_DNA
type: DnaRegion
entity reference: BMP4

DLX5
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1749

POU4F3
type: Protein
entity reference: POU4F3

DACH2_DNA
type: DnaRegion
entity reference: DACH2

http://www.ncbi.nlm.nih.gov/#406991
type: UnificationXref
db: Entrez Gene
id: 406991

PhysicalInteraction [DLL1 -- NOTCH1 ]
type: MolecularInteraction
participant: DLL1
participant: NOTCH1
xref: 17537801
xref: 11006133

CDKN1B_RNA
type: RnaRegion
entity reference: CDKN1B

HCN4
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#10021

OTX2
type: Protein
entity reference: OTX2

HBEGF_DNA
type: DnaRegion
entity reference: HBEGF

http://www.ncbi.nlm.nih.gov/#2637
type: UnificationXref
db: Entrez Gene
id: 2637

CCL2
type: Protein
entity reference: CCL2

TCF3_inactive
type: Protein
entity reference: TCF3

Translation
type: MolecularInteraction
participant: DLX5_inactive
participant: DLX5_RNA

NTF3_RNA
type: RnaRegion
entity reference: NTF3

CD44_DNA
type: DnaRegion
entity reference: CD44

PAX8
type: Protein
entity reference: PAX8

CCL2_DNA
type: DnaRegion
entity reference: CCL2

LFNG
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3955

TCF3
type: Protein
entity reference: TCF3

SIX1_DNA
type: DnaRegion
entity reference: SIX1

OTX2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5015

SPARC_RNA
type: RnaRegion
entity reference: SPARC

http://www.ncbi.nlm.nih.gov/#26232
type: UnificationXref
db: Entrez Gene
id: 26232

Translation
type: MolecularInteraction
participant: SPARC_RNA
participant: SPARC

.NOTCH1.PROMOTES.SOX2.
type: TemplateReactionRegulation
controller: NOTCH1
data source: Spike
controlled: Transcription.Regulation.P.NOTCH1.SOX2
xref: 17537801
control type: ACTIVATION

.EGR1.PROMOTES.ID3.
type: TemplateReactionRegulation
controller: EGR1
data source: Spike
controlled: Transcription.Regulation.P.EGR1.ID3
xref: 12165491
control type: ACTIVATION

http://www.ncbi.nlm.nih.gov/#7849
type: UnificationXref
db: Entrez Gene
id: 7849

BDNF
type: Protein
entity reference: BDNF

.NOTCH1.PROMOTES.PAX8.
type: Catalysis
controller: NOTCH1
control type: ACTIVATION
data source: Spike
controlled: Other.P.NOTCH1.PAX8
xref: 18495817

SIX1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6495

OTX2_DNA
type: DnaRegion
entity reference: OTX2

10954918
type: PublicationXref
db: PubMed
title: A distinct element involved in lipopolysaccharide activation of the tumor necrosis factor-alpha promoter in monocytes
id: 10954918

DACH2_RNA
type: RnaRegion
entity reference: DACH2

http://www.ncbi.nlm.nih.gov/#652
type: UnificationXref
db: Entrez Gene
id: 652

.WNT1.PROMOTES.HES1.
type: Catalysis
controller: WNT1
control type: ACTIVATION
data source: Spike
controlled: Other.P.WNT1.HES1
xref: 18495817

AP-1_I.complex
type: Complex
data source: Spike
name: AP-1 (JUN/:FOS)

.SIX1.INHIBITS.HMX3.
type: Catalysis
controller: SIX1
control type: INHIBITION
data source: Spike
controlled: Translational.Regulation.I.SIX1.HMX3
xref: 14695375

NOTCH1_RNA
type: RnaRegion
entity reference: NOTCH1

http://www.ncbi.nlm.nih.gov/#399823
type: UnificationXref
db: Entrez Gene
id: 399823

.SIX1.PROMOTES.OTX1.
type: TemplateReactionRegulation
controller: SIX1
data source: Spike
controlled: Transcription.Regulation.P.SIX1.OTX1
xref: 14695375
control type: ACTIVATION

.SIX1.INHIBITS.DACH2.
type: TemplateReactionRegulation
controller: SIX1
data source: Spike
controlled: Transcription.Regulation.I.SIX1.DACH2
xref: 14695375
control type: INHIBITION

12068008
type: PublicationXref
db: PubMed
title: Activation of monocyte cyclooxygenase-2 gene expression by human herpesvirus 6. Role for cyclic AMP-responsive element-binding protein and activator protein-1
id: 12068008

http://www.ncbi.nlm.nih.gov/#4843
type: UnificationXref
db: Entrez Gene
id: 4843

.WNT1.PROMOTES.SOX9.
type: Catalysis
controller: WNT1
control type: ACTIVATION
data source: Spike
controlled: Other.P.WNT1.SOX9
xref: 18495817

NOTCH1_DNA
type: DnaRegion
entity reference: NOTCH1

.SIX1.INHIBITS.DLX5.
type: TemplateReactionRegulation
controller: SIX1
data source: Spike
controlled: Transcription.Regulation.I.SIX1.DLX5
xref: 14695375
control type: INHIBITION

DLX5_RNA
type: RnaRegion
entity reference: DLX5

LHX3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8022

XPO6
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#23214

17658230
type: PublicationXref
db: PubMed
title: Manipulating cell cycle regulation in the mature cochlea
id: 17658230

12506144
type: PublicationXref
db: PubMed
title: Selective regulation of ICAM-1 and RANTES gene expression after ICAM-1 ligation on human renal fibroblasts
id: 12506144

http://www.ncbi.nlm.nih.gov/#1749
type: UnificationXref
db: Entrez Gene
id: 1749

NOS2
type: Protein
entity reference: NOS2

GFI1_DNA
type: DnaRegion
entity reference: GFI1

.SIX1.INHIBITS.DACH1.
type: TemplateReactionRegulation
controller: SIX1
data source: Spike
controlled: Transcription.Regulation.I.SIX1.DACH1
xref: 14695375
control type: INHIBITION

PTGS2_RNA
type: RnaRegion
entity reference: PTGS2

.SIX1.PROMOTES.OTX2.
type: TemplateReactionRegulation
controller: SIX1
data source: Spike
controlled: Transcription.Regulation.P.SIX1.OTX2
xref: 14695375
control type: ACTIVATION

FOXI2
type: Protein
entity reference: FOXI2

Translation
type: MolecularInteraction
participant: CXCL2_RNA
participant: CXCL2

http://www.ncbi.nlm.nih.gov/#4851
type: UnificationXref
db: Entrez Gene
id: 4851

SPRY2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#10253

.NOTCH1.PROMOTES.WNT1.
type: Catalysis
controller: NOTCH1
control type: ACTIVATION
data source: Spike
controlled: Other.P.NOTCH1.WNT1
xref: 18495817

14597166
type: PublicationXref
db: PubMed
title: NF-kappaB and c-Jun-dependent regulation of macrophage inflammatory protein-2 gene expression in response to lipopolysaccharide in RAW 264.7 cells
id: 14597166

JAG2_inactive
type: Protein
entity reference: JAG2

11136975
type: PublicationXref
db: PubMed
title: The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest
id: 11136975

16407553
type: PublicationXref
db: PubMed
title: Inhibitors of differentiation and DNA binding (Ids) regulate Math1 and hair cell formation during the development of the organ of Corti
id: 16407553

Homo sapiens
type: BioSource
xref: 9606

http://www.ncbi.nlm.nih.gov/#3714
type: UnificationXref
db: Entrez Gene
id: 3714

10405202
type: PublicationXref
db: PubMed
title: Transcriptional regulation of the interleukin-6 gene in mesangial cells
id: 10405202

RBPJ
type: Protein
entity reference: RBPJ

http://www.ncbi.nlm.nih.gov/#960
type: UnificationXref
db: Entrez Gene
id: 960

.Complex.AP.1 I....PROMOTES.IL6.
type: TemplateReactionRegulation
controller: AP-1_I.complex
data source: Spike
controlled: Transcription.Regulation.P.AP.1 I.IL6
xref: 10405202
xref: 19251936
xref: 11028561
xref: 12626566
xref: 12727841
control type: ACTIVATION

SIX1
type: Protein
entity reference: SIX1

BARHL1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#56751

.SIX1.PROMOTES.FGF3.
type: Catalysis
controller: SIX1
control type: ACTIVATION
data source: Spike
controlled: Other.P.SIX1.FGF3
xref: 12874121

.Complex.AP.1 I....PROMOTES.NOS2.
type: TemplateReactionRegulation
controller: AP-1_I.complex
data source: Spike
controlled: Transcription.Regulation.P.AP.1 I.NOS2
xref: 9712833
control type: ACTIVATION

ATOH1
type: Protein
entity reference: ATOH1

FBXO2
type: Protein
entity reference: FBXO2

.Family.mir.1..MIR1.1,.MIR1.2..INHIBITS.HCN4.
type: Catalysis
controller: mir-1.family
control type: INHIBITION
data source: Spike
controlled: N/A.I.mir.1.HCN4
xref: 18458081

LHX3_DNA
type: DnaRegion
entity reference: LHX3

FOXI2_inactive
type: Protein
entity reference: FOXI2

GATA3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2625

http://www.ncbi.nlm.nih.gov/#6347
type: UnificationXref
db: Entrez Gene
id: 6347

http://www.ncbi.nlm.nih.gov/#3586
type: UnificationXref
db: Entrez Gene
id: 3586

DLL1
type: Protein
entity reference: DLL1

http://www.ncbi.nlm.nih.gov/#5599
type: UnificationXref
db: Entrez Gene
id: 5599

DLL1_inactive
type: Protein
entity reference: DLL1

PTGS2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5743

15725726
type: PublicationXref
db: PubMed
title: Overview of cell death signaling pathways
id: 15725726

HCN4
type: Protein
entity reference: HCN4

PAX2_RNA
type: RnaRegion
entity reference: PAX2

10637481
type: PublicationXref
db: PubMed
title: Intracellular forms of human NOTCH1 interact at distinctly different levels with RBP-jkappa in human B and T cells
id: 10637481

http://www.ncbi.nlm.nih.gov/#9978
type: UnificationXref
db: Entrez Gene
id: 9978

http://www.ncbi.nlm.nih.gov/#5459
type: UnificationXref
db: Entrez Gene
id: 5459

IL6_RNA
type: RnaRegion
entity reference: IL6

CXCL2_DNA
type: DnaRegion
entity reference: CXCL2

.Complex.AP.1 I....PROMOTES.HBEGF.
type: TemplateReactionRegulation
controller: AP-1_I.complex
data source: Spike
controlled: Transcription.Regulation.P.AP.1 I.HBEGF
xref: 10444406
control type: ACTIVATION

Translation
type: MolecularInteraction
participant: BMP4_inactive
participant: BMP4_RNA

http://www.ncbi.nlm.nih.gov/#610
type: UnificationXref
db: Entrez Gene
id: 610

http://www.ncbi.nlm.nih.gov/#7545
type: UnificationXref
db: Entrez Gene
id: 7545

FGF10_inactive
type: Protein
entity reference: FGF10

18384814
type: PublicationXref
db: PubMed
title: miR-21 Gene Expression Triggered by AP-1 Is Sustained through a Double-Negative Feedback Mechanism
id: 18384814

http://www.ncbi.nlm.nih.gov/#6495
type: UnificationXref
db: Entrez Gene
id: 6495

.SOX2.PROMOTES.ATOH1.
type: TemplateReactionRegulation
controller: SOX2
data source: Spike
controlled: Transcription.Regulation.P.SOX2.ATOH1
xref: 15846349
control type: ACTIVATION

BMP4_inactive
type: Protein
entity reference: BMP4

http://www.ncbi.nlm.nih.gov/#6772
type: UnificationXref
db: Entrez Gene
id: 6772

EGR1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1958

19043405
type: PublicationXref
db: PubMed
title: MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
id: 19043405

.SIX1.PROMOTES.FGF10.
type: Catalysis
controller: SIX1
control type: ACTIVATION
data source: Spike
controlled: Dephosphorylation.P.SIX1.FGF10
xref: 12874121

MIR1-2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#406905

Translation
type: MolecularInteraction
participant: NTF3
participant: NTF3_RNA

11292836
type: PublicationXref
db: PubMed
title: Activator protein-1 transcription factor mediates bombesin-stimulated cyclooxygenase-2 expression in intestinal epithelial cells
id: 11292836

RBX1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9978

http://www.ncbi.nlm.nih.gov/#5076
type: UnificationXref
db: Entrez Gene
id: 5076

.NOTCH1.INHIBITS.ATOH1.
type: TemplateReactionRegulation
controller: NOTCH1
data source: Spike
controlled: Transcription.Regulation.I.NOTCH1.ATOH1
xref: 16283144
control type: INHIBITION

AP-1_I.complex_DNA
type: DnaRegion

CXCL2_RNA
type: RnaRegion
entity reference: CXCL2

SIX1_inactive
type: Protein
entity reference: SIX1

NOS2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4843

ID2
type: Protein
entity reference: ID2

http://www.ncbi.nlm.nih.gov/#6678
type: UnificationXref
db: Entrez Gene
id: 6678

.ATOH1.PROMOTES.POU4F3.
type: TemplateReactionRegulation
controller: ATOH1
data source: Spike
controlled: Transcription.Regulation.P.ATOH1.POU4F3
xref: 15254021
control type: ACTIVATION

PAX8_inactive
type: Protein
entity reference: PAX8

11925568
type: PublicationXref
db: PubMed
title: c-fos regulates neuronal excitability and survival
id: 11925568

NOTCH1
type: Protein
entity reference: NOTCH1

18676839
type: PublicationXref
db: PubMed
title: Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer
id: 18676839

BDNF_DNA
type: DnaRegion
entity reference: BDNF

G6PD_inactive
type: Protein
entity reference: G6PD

http://www.ncbi.nlm.nih.gov/#3569
type: UnificationXref
db: Entrez Gene
id: 3569

LHX3_RNA
type: RnaRegion
entity reference: LHX3

.Complex.AP.1 I....PROMOTES.TNF.
type: TemplateReactionRegulation
controller: AP-1_I.complex
data source: Spike
controlled: Transcription.Regulation.P.AP.1 I.TNF
xref: 10954918
xref: 11991968
control type: ACTIVATION

12727841
type: PublicationXref
db: PubMed
title: Constitutive activation of nuclear factor kappaB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer
id: 12727841

http://www.ncbi.nlm.nih.gov/#627
type: UnificationXref
db: Entrez Gene
id: 627

http://www.ncbi.nlm.nih.gov/#1602
type: UnificationXref
db: Entrez Gene
id: 1602

HES1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3280

ATOH1_RNA
type: RnaRegion
entity reference: ATOH1

http://www.ncbi.nlm.nih.gov/#6662
type: UnificationXref
db: Entrez Gene
id: 6662

11991968
type: PublicationXref
db: PubMed
title: Regulation of tumor necrosis factor alpha promoter by human parvovirus B19 NS1 through activation of AP-1 and AP-2
id: 11991968

CDKN1A_RNA
type: RnaRegion
entity reference: CDKN1A

JAG1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#182

10801845
type: PublicationXref
db: PubMed
title: Cell cycle-regulated phosphorylation of the human SIX1 homeodomain protein
id: 10801845

.NOTCH1.PROMOTES.JAG1.
type: TemplateReactionRegulation
controller: NOTCH1
data source: Spike
controlled: Transcription.Regulation.P.NOTCH1.JAG1
xref: 18495817
control type: ACTIVATION

HMX3
type: Protein
entity reference: HMX3

11734542
type: PublicationXref
db: PubMed
title: Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome
id: 11734542

ICAM1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3383

CDKN1B_inactive
type: Protein
entity reference: CDKN1B

.NOTCH1.PROMOTES.HES1.
type: Catalysis
controller: NOTCH1
control type: ACTIVATION
data source: Spike
controlled: Other.P.NOTCH1.HES1
xref: 18495817

ATOH1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#474

ZIC1
type: Protein
entity reference: ZIC1

SKP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6500

.WNT1.PROMOTES.PAX2.
type: Catalysis
controller: WNT1
control type: ACTIVATION
data source: Spike
controlled: Other.P.WNT1.PAX2
xref: 18495817

http://www.ncbi.nlm.nih.gov/#6657
type: UnificationXref
db: Entrez Gene
id: 6657

CK2.complex
type: Complex
data source: Spike
name: Caseine Kinase 2

http://www.ncbi.nlm.nih.gov/#5015
type: UnificationXref
db: Entrez Gene
id: 5015

http://www.ncbi.nlm.nih.gov/#2672
type: UnificationXref
db: Entrez Gene
id: 2672

.ID2.INHIBITS.ATOH1.
type: TemplateReactionRegulation
controller: ID2
data source: Spike
controlled: Transcription.Regulation.I.ID2.ATOH1
xref: 16407553
control type: INHIBITION

http://www.ncbi.nlm.nih.gov/#5013
type: UnificationXref
db: Entrez Gene
id: 5013

NOS2_RNA
type: RnaRegion
entity reference: NOS2

11786300
type: PublicationXref
db: PubMed
title: Cholesterol enrichment upregulates intercellular adhesion molecule-1 in human vascular endothelial cells
id: 11786300

SPRY2
type: Protein
entity reference: SPRY2

FGF3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2248

.Complex.CK2....INHIBITS.SIX1.
type: Catalysis
controller: CK2.complex
control type: INHIBITION
data source: Spike
controlled: Phosphorylation.I.CK2.SIX1
xref: 10801845

Spike
type: Provenance

Translation
type: MolecularInteraction
participant: BDNF_RNA
participant: BDNF_inactive

SCF.complex
type: Complex
data source: Spike
component: RBX1
component: SKP1
name: SCF-FBXW7

18521080
type: PublicationXref
db: PubMed
title: MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma
id: 18521080

.ID1.INHIBITS.ATOH1.
type: TemplateReactionRegulation
controller: ID1
data source: Spike
controlled: Transcription.Regulation.I.ID1.ATOH1
xref: 16407553
control type: INHIBITION

14978197
type: PublicationXref
db: PubMed
title: Dual Regulation of Tumor Necrosis Factor-alpha-Induced CCL2/Monocyte Chemoattractant Protein-1 Expression in Vascular Smooth Muscle Cells by Nuclear Factor-kappaB and Activator Protein-1: Modulation by Type III Phosphodiesterase Inhibition
id: 14978197

FGF3_inactive
type: Protein
entity reference: FGF3

.HES5.INHIBITS.ATOH1.
type: Catalysis
controller: HES5
control type: INHIBITION
data source: Spike
controlled: Physical.Interaction.I.HES5.ATOH1
xref: 15358736

POU4F3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5459

mir-221.family
type: Protein
data source: Spike
xref: TAU:F.329923

.STAT1.PROMOTES.CDKN1B.
type: TemplateReactionRegulation
controller: STAT1
data source: Spike
controlled: Transcription.Regulation.P.STAT1.CDKN1B
xref: 17992189
control type: ACTIVATION

OTX2_RNA
type: RnaRegion
entity reference: OTX2

mir-1.family
type: Protein
member physical entity: MIR1-1
member physical entity: MIR1-2
data source: Spike
xref: TAU:F.329920

.Complex.AP.1 I....PROMOTES.IL10.
type: TemplateReactionRegulation
controller: AP-1_I.complex
data source: Spike
controlled: Transcription.Regulation.P.AP.1 I.IL10
xref: 12649301
control type: ACTIVATION

WNT1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7471

Translation
type: MolecularInteraction
participant: DACH2_RNA
participant: DACH2

http://www.ncbi.nlm.nih.gov/#6500
type: UnificationXref
db: Entrez Gene
id: 6500

WNT1
type: Protein
entity reference: WNT1

http://www.ncbi.nlm.nih.gov/#6502
type: UnificationXref
db: Entrez Gene
id: 6502

BMP4_RNA
type: RnaRegion
entity reference: BMP4

HES5
type: Protein
entity reference: HES5

G6PD
type: Protein
entity reference: G6PD

BARHL1_RNA
type: RnaRegion
entity reference: BARHL1

http://www.ncbi.nlm.nih.gov/#5743
type: UnificationXref
db: Entrez Gene
id: 5743

Translation
type: MolecularInteraction
participant: POU4F3
participant: POU4F3_RNA

PAX8
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7849

PAX2_DNA
type: DnaRegion
entity reference: PAX2

CD44
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#960

.Complex.AP.1 I....INHIBITS.SPARC.
type: TemplateReactionRegulation
controller: AP-1_I.complex
data source: Spike
controlled: Transcription.Regulation.I.AP.1 I.SPARC
xref: 10777211
xref: 11042689
control type: INHIBITION

http://www.ncbi.nlm.nih.gov/#2299
type: UnificationXref
db: Entrez Gene
id: 2299

14695375
type: PublicationXref
db: PubMed
title: Six1 controls patterning of the mouse otic vesicle
id: 14695375

http://www.ncbi.nlm.nih.gov/#474
type: UnificationXref
db: Entrez Gene
id: 474

EGR1
type: Protein
entity reference: EGR1

NOS2_DNA
type: DnaRegion
entity reference: NOS2

.NOTCH1.PROMOTES.BMP4.
type: TemplateReactionRegulation
controller: NOTCH1
data source: Spike
controlled: Transcription.Regulation.P.NOTCH1.BMP4
xref: 17537801
control type: ACTIVATION

.WNT1.PROMOTES.JAG1.
type: Catalysis
controller: WNT1
control type: ACTIVATION
data source: Spike
controlled: Other.P.WNT1.JAG1
xref: 18495817

IL10_DNA
type: DnaRegion
entity reference: IL10

http://www.ncbi.nlm.nih.gov/#4908
type: UnificationXref
db: Entrez Gene
id: 4908

DACH2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#117154

18508928
type: PublicationXref
db: PubMed
title: MicroRNA-21 Targets Sprouty2 and Promotes Cellular Outgrowths
id: 18508928

DACH2
type: Protein
entity reference: DACH2

FOXI2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#399823

AP-1_I.complex_RNA
type: RnaRegion

.SIX1.INHIBITS.EYA1.
type: TemplateReactionRegulation
controller: SIX1
data source: Spike
controlled: Transcription.Regulation.I.SIX1.EYA1
xref: 17035528
control type: INHIBITION

http://www.ncbi.nlm.nih.gov/#3516
type: UnificationXref
db: Entrez Gene
id: 3516

DLX5
type: Protein
entity reference: DLX5

GBX2_inactive
type: Protein
entity reference: GBX2

9001250
type: PublicationXref
db: PubMed
title: AP-1-mediated invasion requires increased expression of the hyaluronan receptor CD44
id: 9001250

15016815
type: PublicationXref
db: PubMed
title: E2A/HEB and Id3 proteins control the sensitivity to glucocorticoid-induced apoptosis in thymocytes by regulating the SRG3 expression
id: 15016815

TCF3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6929

SOX2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6657

ID1
type: Protein
entity reference: ID1

.Complex.AP.1 I....PROMOTES.BDNF.
type: TemplateReactionRegulation
controller: AP-1_I.complex
data source: Spike
controlled: Transcription.Regulation.P.AP.1 I.BDNF
xref: 11925568
control type: ACTIVATION

.JAG1.PROMOTES.CDKN1B.
type: Catalysis
controller: JAG1
control type: ACTIVATION
data source: Spike
controlled: Other.P.JAG1.CDKN1B
xref: 16495313

HBEGF
type: Protein
entity reference: HBEGF

JAG1_inactive
type: Protein
entity reference: JAG1

BMP4
type: Protein
entity reference: BMP4

http://www.ncbi.nlm.nih.gov/#2539
type: UnificationXref
db: Entrez Gene
id: 2539

18458081
type: PublicationXref
db: PubMed
title: Downregulation of MIRNA-1/MIRNA-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart
id: 18458081

Translation
type: MolecularInteraction
participant: IL6_RNA
participant: IL6

CXCL2
type: Protein
entity reference: CXCL2

DACH1_RNA
type: RnaRegion
entity reference: DACH1

http://www.ncbi.nlm.nih.gov/#182
type: UnificationXref
db: Entrez Gene
id: 182

http://www.ncbi.nlm.nih.gov/#2248
type: UnificationXref
db: Entrez Gene
id: 2248

.MAPK8.PROMOTES.Complex.AP.1 I....
type: TemplateReactionRegulation
controller: MAPK8
data source: Spike
controlled: Transcription.Regulation.P.MAPK8.AP.1 I
xref: 15725726
control type: ACTIVATION

18413744
type: PublicationXref
db: PubMed
title: MicroRNAs 221 and 222 bypass quiescence and compromise cell survival
id: 18413744

MIR21
type: Protein
entity reference: MIR21

Translation
type: MolecularInteraction
participant: ICAM1
participant: ICAM1_RNA

http://www.ncbi.nlm.nih.gov/#6929
type: UnificationXref
db: Entrez Gene
id: 6929

CDKN1A_DNA
type: DnaRegion
entity reference: CDKN1A

16283144
type: PublicationXref
db: PubMed
title: Inhibition of Notch/RBP-J signaling induces hair cell formation in neonate mouse cochleas
id: 16283144

WNT1_inactive
type: Protein
entity reference: WNT1

IL6
type: Protein
entity reference: IL6

HCN2_inactive
type: Protein
entity reference: HCN2

PhysicalInteraction [ATOH1 -- SKP2 ]
type: MolecularInteraction
participant: ATOH1
participant: SKP2
xref: 17658230

http://www.ncbi.nlm.nih.gov/#2255
type: UnificationXref
db: Entrez Gene
id: 2255

Translation
type: MolecularInteraction
participant: LHX3_RNA
participant: LHX3

Translation
type: MolecularInteraction
participant: MIR21_RNA
participant: MIR21

PTGS2
type: Protein
entity reference: PTGS2

CCL2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6347

.ATOH1.PROMOTES.BARHL1.
type: TemplateReactionRegulation
controller: ATOH1
data source: Spike
controlled: Transcription.Regulation.P.ATOH1.BARHL1
xref: 18212062
control type: ACTIVATION

Translation
type: MolecularInteraction
participant: BARHL1
participant: BARHL1_RNA

ID3
type: Protein
entity reference: ID3

DACH1_DNA
type: DnaRegion
entity reference: DACH1

FGF10
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2255

SPARC
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6678

http://www.ncbi.nlm.nih.gov/#117154
type: UnificationXref
db: Entrez Gene
id: 117154

.Complex.AP.1 I....PROMOTES.ICAM1.
type: TemplateReactionRegulation
controller: AP-1_I.complex
data source: Spike
controlled: Transcription.Regulation.P.AP.1 I.ICAM1
xref: 12506144
xref: 11786300
control type: ACTIVATION

.FOXI1.PROMOTES.SIX1.
type: TemplateReactionRegulation
controller: FOXI1
data source: Spike
controlled: Transcription.Regulation.P.FOXI1.SIX1
xref: 17035528
control type: ACTIVATION

Translation
type: MolecularInteraction
participant: EYA1_RNA
participant: EYA1

IL10
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3586

Translation
type: MolecularInteraction
participant: GFI1_RNA
participant: GFI1

TNF_DNA
type: DnaRegion
entity reference: TNF

Translation
type: MolecularInteraction
participant: ATOH1_RNA
participant: ATOH1_inactive

SKP1
type: Protein
entity reference: SKP1

Translation
type: MolecularInteraction
participant: SOX2_RNA
participant: SOX2

Translation
type: MolecularInteraction
participant: SIX1_inactive
participant: SIX1_RNA

POU4F3_RNA
type: RnaRegion
entity reference: POU4F3

IL10
type: Protein
entity reference: IL10

Translation
type: MolecularInteraction
participant: HBEGF_RNA
participant: HBEGF

SKP2
type: Protein
entity reference: SKP2

MIR21
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#406991

.POU4F3.PROMOTES.NTF3.
type: TemplateReactionRegulation
controller: POU4F3
data source: Spike
controlled: Transcription.Regulation.P.POU4F3.NTF3
xref: 15465029
control type: ACTIVATION

NTF3
type: Protein
entity reference: NTF3

NOTCH1-RBPJ.complex
type: Complex
data source: Spike
component: RBPJ
component: NOTCH1
name: NOTCH1-RBPJ (RBPSUH)

15492887
type: PublicationXref
db: PubMed
title: A comparative study of Eya1 and Eya4 protein function and its implication in branchio-oto-renal syndrome and DFNA10
id: 15492887

SOX9_inactive
type: Protein
entity reference: SOX9

OTX1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5013

NOTCH1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4851

17331196
type: PublicationXref
db: PubMed
title: Lhx3, a LIM domain transcription factor, is regulated by Pou4f3 in the auditory but not in the vestibular system
id: 17331196

http://www.ncbi.nlm.nih.gov/#340784
type: UnificationXref
db: Entrez Gene
id: 340784

ID2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3398

GBX2
type: Protein
entity reference: GBX2

11028561
type: PublicationXref
db: PubMed
title: The transcription factor activator protein-1 is activated and interleukin-6 production is increased in interleukin-1beta-stimulated human enterocytes
id: 11028561

.WNT1.PROMOTES.NOTCH1.
type: Catalysis
controller: WNT1
control type: ACTIVATION
data source: Spike
controlled: Other.P.WNT1.NOTCH1
xref: 18495817

OTX1_RNA
type: RnaRegion
entity reference: OTX1

.Family.mir.1..MIR1.1,.MIR1.2..INHIBITS.G6PD.
type: Catalysis
controller: mir-1.family
control type: INHIBITION
data source: Spike
controlled: N/A.I.mir.1.G6PD
xref: 14697198

.Complex.SCF..SKP1,.RBX1..INHIBITS.CDKN1B.
type: Catalysis
controller: SCF.complex
control type: INHIBITION
data source: Spike
controlled: Ubiquitination.I.SCF.CDKN1B
xref: 15199159

MAPK8
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5599

HES5_RNA
type: RnaRegion
entity reference: HES5

.Complex.AP.1 I....PROMOTES.CD44.
type: TemplateReactionRegulation
controller: AP-1_I.complex
data source: Spike
controlled: Transcription.Regulation.P.AP.1 I.CD44
xref: 9001250
control type: ACTIVATION

EYA1_RNA
type: RnaRegion
entity reference: EYA1

BDNF
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#627

TNF
type: Protein
entity reference: TNF

Translation
type: MolecularInteraction
participant: CDKN1A
participant: CDKN1A_RNA

ID3_DNA
type: DnaRegion
entity reference: ID3

HCN2
type: Protein
entity reference: HCN2

12874121
type: PublicationXref
db: PubMed
title: The role of Six1 in mammalian auditory system development
id: 12874121

15846349
type: PublicationXref
db: PubMed
title: Sox2 is required for sensory organ development in the mammalian inner ear
id: 15846349

HES1
type: Protein
entity reference: HES1

.ATOH1.PROMOTES.HES5.
type: Catalysis
controller: ATOH1
control type: ACTIVATION
data source: Spike
controlled: Physical.Interaction.P.ATOH1.HES5
xref: 15358736

.ID3.INHIBITS.ATOH1.
type: TemplateReactionRegulation
controller: ID3
data source: Spike
controlled: Transcription.Regulation.I.ID3.ATOH1
xref: 16407553
control type: INHIBITION

.NOTCH1.INHIBITS.DLL1.
type: Catalysis
controller: NOTCH1
control type: INHIBITION
data source: Spike
controlled: Physical.Interaction.I.NOTCH1.DLL1
xref: 15358736

Translation
type: MolecularInteraction
participant: HES5_inactive
participant: HES5_RNA

.Complex.AP.1 I....PROMOTES.MIR21.
type: TemplateReactionRegulation
controller: AP-1_I.complex
data source: Spike
controlled: Transcription.Regulation.P.AP.1 I.MIR21
xref: 18384814
control type: ACTIVATION

HBEGF_RNA
type: RnaRegion
entity reference: HBEGF

DLL1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#28514

.NOTCH1.PROMOTES.HES5.
type: TemplateReactionRegulation
controller: NOTCH1
data source: Spike
controlled: Transcription.Regulation.P.NOTCH1.HES5
xref: 17537801
xref: 16283144
control type: ACTIVATION

HBEGF
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1839

http://www.ncbi.nlm.nih.gov/#56751
type: UnificationXref
db: Entrez Gene
id: 56751

.SIX1.PROMOTES.LFNG.
type: Catalysis
controller: SIX1
control type: ACTIVATION
data source: Spike
controlled: Translational.Regulation.P.SIX1.LFNG
xref: 14695375

BDNF_RNA
type: RnaRegion
entity reference: BDNF

IL10_RNA
type: RnaRegion
entity reference: IL10

CDKN1B
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1027

GFI1_RNA
type: RnaRegion
entity reference: GFI1

TNF
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7124

12642498
type: PublicationXref
db: PubMed
title: Zic1 represses Math1 expression via interactions with the Math1 enhancer and modulation of Math1 autoregulation
id: 12642498

SPRY1_inactive
type: Protein
entity reference: SPRY1

IL6
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3569

.ZIC1.INHIBITS.ATOH1.
type: Catalysis
controller: ZIC1
control type: INHIBITION
data source: Spike
controlled: Physical.Interaction.I.ZIC1.ATOH1
xref: 12642498

.NOTCH1.INHIBITS.FOXI2.
type: Catalysis
controller: NOTCH1
control type: INHIBITION
data source: Spike
controlled: Other.I.NOTCH1.FOXI2
xref: 18495817

CDKN1A
type: Protein
entity reference: CDKN1A

SPRY2_inactive
type: Protein
entity reference: SPRY2

GATA3
type: Protein
entity reference: GATA3

HCN4_inactive
type: Protein
entity reference: HCN4

.SIX1.PROMOTES.BMP4.
type: Catalysis
controller: SIX1
control type: ACTIVATION
data source: Spike
controlled: N/A.P.SIX1.BMP4
xref: 12874121

SPARC_DNA
type: DnaRegion
entity reference: SPARC

http://www.ncbi.nlm.nih.gov/#8022
type: UnificationXref
db: Entrez Gene
id: 8022

11042689
type: PublicationXref
db: PubMed
title: Transcriptional control of SPARC by v-Jun and other members of the AP1 family of transcription factors
id: 11042689

.Family.mir.1..MIR1.1,.MIR1.2..INHIBITS.HCN2.
type: Catalysis
controller: mir-1.family
control type: INHIBITION
data source: Spike
controlled: N/A.I.mir.1.HCN2
xref: 18458081

GATA3_inactive
type: Protein
entity reference: GATA3

.WNT1.PROMOTES.PAX8.
type: Catalysis
controller: WNT1
control type: ACTIVATION
data source: Spike
controlled: Other.P.WNT1.PAX8
xref: 18495817

.POU4F3.PROMOTES.BDNF.
type: TemplateReactionRegulation
controller: POU4F3
data source: Spike
controlled: Transcription.Regulation.P.POU4F3.BDNF
xref: 15465029
control type: ACTIVATION

ICAM1_DNA
type: DnaRegion
entity reference: ICAM1

ICAM1
type: Protein
entity reference: ICAM1

SOX2_DNA
type: DnaRegion
entity reference: SOX2

12649301
type: PublicationXref
db: PubMed
title: Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs
id: 12649301

Translation
type: MolecularInteraction
participant: PAX2_RNA
participant: PAX2_inactive

http://www.ncbi.nlm.nih.gov/#1839
type: UnificationXref
db: Entrez Gene
id: 1839

Translation
type: MolecularInteraction
participant: CDKN1B_RNA
participant: CDKN1B_inactive

NUMB
type: Protein
entity reference: NUMB

Translation
type: MolecularInteraction
participant: CCL2
participant: CCL2_RNA

http://www.ncbi.nlm.nih.gov/#7124
type: UnificationXref
db: Entrez Gene
id: 7124

MIR21_RNA
type: RnaRegion
entity reference: MIR21

SOX9
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6662

.Complex.NOTCH1.RBPJ..NOTCH1,.RBPJ..PROMOTES.HES5.
type: TemplateReactionRegulation
controller: NOTCH1-RBPJ.complex
data source: Spike
controlled: Transcription.Regulation.P.NOTCH1.RBPJ.HES5
xref: 10637481
xref: 20972443
control type: ACTIVATION

9606
type: UnificationXref
db: taxonomy
id: 9606

IL6_DNA
type: DnaRegion
entity reference: IL6

Translation
type: MolecularInteraction
participant: AP-1_I.complex_RNA
participant: AP-1_I.complex

PAX2_inactive
type: Protein
entity reference: PAX2

SPRY1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#10252

FGF3
type: Protein
entity reference: FGF3

15199159
type: PublicationXref
db: PubMed
title: Noncatalytic requirement for cyclin A-cdk2 in p27 turnover
id: 15199159

Translation
type: MolecularInteraction
participant: CD44_RNA
participant: CD44

9712833
type: PublicationXref
db: PubMed
title: Cytokine-mediated transcriptional induction of the human inducible nitric oxide synthase gene requires both activator protein 1 and nuclear factor kappaB-binding sites
id: 9712833

CD44
type: Protein
entity reference: CD44

http://www.ncbi.nlm.nih.gov/#3955
type: UnificationXref
db: Entrez Gene
id: 3955

12165491
type: PublicationXref
db: PubMed
title: Thymocyte development in early growth response gene 1-deficient mice
id: 12165491

FOXI1
type: Protein
entity reference: FOXI1

http://www.ncbi.nlm.nih.gov/#10252
type: UnificationXref
db: Entrez Gene
id: 10252

http://www.ncbi.nlm.nih.gov/#1026
type: UnificationXref
db: Entrez Gene
id: 1026

http://www.ncbi.nlm.nih.gov/#10253
type: UnificationXref
db: Entrez Gene
id: 10253

http://www.ncbi.nlm.nih.gov/#1027
type: UnificationXref
db: Entrez Gene
id: 1027

PAX2
type: Protein
entity reference: PAX2

SOX9
type: Protein
entity reference: SOX9

.NUMB.INHIBITS.NOTCH1.
type: Catalysis
controller: NUMB
control type: INHIBITION
data source: Spike
controlled: N/A.I.NUMB.NOTCH1
xref: 15358736

LHX3
type: Protein
entity reference: LHX3

HMX3_inactive
type: Protein
entity reference: HMX3

EYA1_DNA
type: DnaRegion
entity reference: EYA1

MIR1-1
type: Protein
entity reference: MIR1-1

ID3_RNA
type: RnaRegion
entity reference: ID3

LFNG_inactive
type: Protein
entity reference: LFNG

XPO6
type: Protein
entity reference: XPO6

BDNF_inactive
type: Protein
entity reference: BDNF

.WNT1.PROMOTES.GBX2.
type: Catalysis
controller: WNT1
control type: ACTIVATION
data source: Spike
controlled: Other.P.WNT1.GBX2
xref: 18495817

SOX2
type: Protein
entity reference: SOX2

ID1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3397

15022320
type: PublicationXref
db: PubMed
title: MEK/ERK and signal transducer and activator of transcription signaling pathways modulate oncostatin M-stimulated CCL2 expression in human osteoblasts through a common transcription factor
id: 15022320

G6PD
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2539

Translation
type: MolecularInteraction
participant: DACH1_RNA
participant: DACH1

Translation
type: MolecularInteraction
participant: NOTCH1_RNA
participant: NOTCH1_inactive

HES5_inactive
type: Protein
entity reference: HES5

.NOTCH1.INHIBITS.JAG2.
type: Catalysis
controller: NOTCH1
control type: INHIBITION
data source: Spike
controlled: Physical.Interaction.I.NOTCH1.JAG2
xref: 15358736

HCN2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#610

http://www.ncbi.nlm.nih.gov/#3383
type: UnificationXref
db: Entrez Gene
id: 3383

10777211
type: PublicationXref
db: PubMed
title: Down-regulation of the extracellular matrix protein SPARC in vSrc- and vJun-transformed chick embryo fibroblasts contributes to tumor formation in vivo
id: 10777211

15254021
type: PublicationXref
db: PubMed
title: Transcription profiling of inner ears from Pou4f3(ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene
id: 15254021

17035528
type: PublicationXref
db: PubMed
title: The transcription factor six1 inhibits neuronal and promotes hair cell fate in the developing zebrafish (Danio rerio) inner ear
id: 17035528

DLX5_inactive
type: Protein
entity reference: DLX5

RBX1
type: Protein
entity reference: RBX1

MIR21_DNA
type: DnaRegion
entity reference: MIR21

18495817
type: PublicationXref
db: PubMed
title: Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode
id: 18495817

STAT1
type: Protein
entity reference: STAT1

http://www.ncbi.nlm.nih.gov/#406905
type: UnificationXref
db: Entrez Gene
id: 406905

http://www.ncbi.nlm.nih.gov/#406904
type: UnificationXref
db: Entrez Gene
id: 406904

SOX2_RNA
type: RnaRegion
entity reference: SOX2

http://www.ncbi.nlm.nih.gov/#2920
type: UnificationXref
db: Entrez Gene
id: 2920

http://www.ncbi.nlm.nih.gov/#10021
type: UnificationXref
db: Entrez Gene
id: 10021

.JAG1.PROMOTES.NOTCH1.
type: TemplateReactionRegulation
controller: JAG1
data source: Spike
controlled: Transcription.Regulation.P.JAG1.NOTCH1
xref: 18495817
control type: ACTIVATION

SKP2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6502

http://www.ncbi.nlm.nih.gov/#3397
type: UnificationXref
db: Entrez Gene
id: 3397

JAG2
type: Protein
entity reference: JAG2

http://www.ncbi.nlm.nih.gov/#3398
type: UnificationXref
db: Entrez Gene
id: 3398

TAU:F.329920
type: UnificationXref
db: Spike DB
id: TAU:F-329920

http://www.ncbi.nlm.nih.gov/#3399
type: UnificationXref
db: Entrez Gene
id: 3399

POU4F3_DNA
type: DnaRegion
entity reference: POU4F3

17992189
type: PublicationXref
db: PubMed
title: Identification of a novel p53-dependent activation pathway of STAT1 by antitumour genotoxic agents
id: 17992189

FGF10
type: Protein
entity reference: FGF10

ZIC1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7545

STAT1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6772

.MIR21.INHIBITS.SPRY2.
type: Catalysis
controller: MIR21
control type: INHIBITION
data source: Spike
controlled: N/A.I.MIR21.SPRY2
xref: 18508928

MAPK8
type: Protein
entity reference: MAPK8

.POU4F3.PROMOTES.LHX3.
type: TemplateReactionRegulation
controller: POU4F3
data source: Spike
controlled: Transcription.Regulation.P.POU4F3.LHX3
xref: 17331196
control type: ACTIVATION

TAU:F.329923
type: UnificationXref
db: Spike DB
id: TAU:F-329923

15358736
type: PublicationXref
db: PubMed
title: The developmental genetics of auditory hair cells
id: 15358736

http://www.ncbi.nlm.nih.gov/#28514
type: UnificationXref
db: Entrez Gene
id: 28514

ICAM1_RNA
type: RnaRegion
entity reference: ICAM1

OTX1_DNA
type: DnaRegion
entity reference: OTX1

PAX2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5076

.ID3.INHIBITS.TCF3.
type: Catalysis
controller: ID3
control type: INHIBITION
data source: Spike
controlled: Physical.Interaction.I.ID3.TCF3
xref: 15016815
xref: 12614353
xref: 11175815

.Complex.AP.1 I....INHIBITS.CDKN1A.
type: TemplateReactionRegulation
controller: AP-1_I.complex
data source: Spike
controlled: Transcription.Regulation.I.AP.1 I.CDKN1A
xref: 11136975
control type: INHIBITION

BARHL1_DNA
type: DnaRegion
entity reference: BARHL1

JAG1_RNA
type: RnaRegion
entity reference: JAG1

HES5_DNA
type: DnaRegion
entity reference: HES5

.Family.mir.1..MIR1.1,.MIR1.2..INHIBITS.XPO6.
type: Catalysis
controller: mir-1.family
control type: INHIBITION
data source: Spike
controlled: N/A.I.mir.1.XPO6
xref: 18676839

10444406
type: PublicationXref
db: PubMed
title: AP-1 mediates stretch-induced expression of HB-EGF in bladder smooth muscle cells
id: 10444406

ATOH1_DNA
type: DnaRegion
entity reference: ATOH1

DACH1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1602

HMX3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#340784

.Family.mir.221....INHIBITS.CDKN1B.
type: Catalysis
controller: mir-221.family
control type: INHIBITION
data source: Spike
controlled: N/A.I.mir.221.CDKN1B
xref: 18521080
xref: 18413744

SIX1_RNA
type: RnaRegion
entity reference: SIX1

EYA1
type: Protein
entity reference: EYA1

Translation
type: MolecularInteraction
participant: TNF
participant: TNF_RNA

TNF_RNA
type: RnaRegion
entity reference: TNF

18212062
type: PublicationXref
db: PubMed
title: Barhl1 regulatory sequences required for cell-specific gene expression and autoregulation in the inner ear and central nervous system
id: 18212062

PhysicalInteraction [EYA1 -- SIX1 ]
type: MolecularInteraction
participant: EYA1
participant: SIX1
xref: 15492887
xref: 11734542

.POU4F3.PROMOTES.GFI1.
type: TemplateReactionRegulation
controller: POU4F3
data source: Spike
controlled: Transcription.Regulation.P.POU4F3.GFI1
xref: 15254021
control type: ACTIVATION

11006133
type: PublicationXref
db: PubMed
title: Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors
id: 11006133

NTF3_DNA
type: DnaRegion
entity reference: NTF3

Translation
type: MolecularInteraction
participant: OTX2_RNA
participant: OTX2

Translation
type: MolecularInteraction
participant: ID3_RNA
participant: ID3

http://www.ncbi.nlm.nih.gov/#2138
type: UnificationXref
db: Entrez Gene
id: 2138

NTF3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4908

HES5
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#388585

ID3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3399

PhysicalInteraction [FBXO2 -- SKP1 ]
type: MolecularInteraction
participant: FBXO2
participant: SKP1
xref: 17494702

CDKN1B_DNA
type: DnaRegion
entity reference: CDKN1B

NUMB
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8650

http://www.ncbi.nlm.nih.gov/#1958
type: UnificationXref
db: Entrez Gene
id: 1958

http://www.ncbi.nlm.nih.gov/#23214
type: UnificationXref
db: Entrez Gene
id: 23214

JAG1_DNA
type: DnaRegion
entity reference: JAG1

.WNT1.PROMOTES.DLX5.
type: Catalysis
controller: WNT1
control type: ACTIVATION
data source: Spike
controlled: Other.P.WNT1.DLX5
xref: 18495817

GBX2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2637

NOTCH1_inactive
type: Protein
entity reference: NOTCH1

.NOTCH1.PROMOTES.NOTCH1.
type: Catalysis
controller: NOTCH1
control type: ACTIVATION
data source: Spike
controlled: Other.P.NOTCH1.NOTCH1
xref: 18495817

JAG1
type: Protein
entity reference: JAG1

http://www.ncbi.nlm.nih.gov/#3280
type: UnificationXref
db: Entrez Gene
id: 3280

.RBPJ.INHIBITS.HES5.
type: TemplateReactionRegulation
controller: RBPJ
data source: Spike
controlled: Transcription.Regulation.I.RBPJ.HES5
control type: INHIBITION

.Complex.AP.1 I....PROMOTES.CCL2.
type: TemplateReactionRegulation
controller: AP-1_I.complex
data source: Spike
controlled: Transcription.Regulation.P.AP.1 I.CCL2
xref: 14978197
xref: 15022320
control type: ACTIVATION

SPRY1
type: Protein
entity reference: SPRY1

.WNT1.INHIBITS.FOXI2.
type: Catalysis
controller: WNT1
control type: INHIBITION
data source: Spike
controlled: Other.I.WNT1.FOXI2
xref: 18495817

FBXO2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#26232

ATOH1_inactive
type: Protein
entity reference: ATOH1

.MIR21.INHIBITS.SPRY1.
type: Catalysis
controller: MIR21
control type: INHIBITION
data source: Spike
controlled: N/A.I.MIR21.SPRY1
xref: 19043405

PTGS2_DNA
type: DnaRegion
entity reference: PTGS2

MIR1-1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#406904

17537801
type: PublicationXref
db: PubMed
title: Notch signalling is needed to maintain, but not to initiate, the formation of prosensory patches in the chick inner ear
id: 17537801

BARHL1
type: Protein
entity reference: BARHL1

JAG2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3714

.SIX1.PROMOTES.DACH1.
type: TemplateReactionRegulation
controller: SIX1
data source: Spike
controlled: Transcription.Regulation.P.SIX1.DACH1
xref: 17035528
control type: ACTIVATION