EDN1
type: Protein
entity reference: EDN1

AMPK.complex
type: Complex
name: 5'-AMP-activated protein kinase
data source: Spike

http://www.ncbi.nlm.nih.gov/#7399
type: UnificationXref
db: Entrez Gene
id: 7399

GAPDH_inactive
type: Protein
entity reference: GAPDH

.TUB.PROMOTES.MAPK3.
type: Catalysis
xref: 19114066
controlled: N/A.P.TUB.MAPK3
control type: ACTIVATION
data source: Spike
controller: TUB

PCDH15
type: Protein
entity reference: PCDH15

http://www.ncbi.nlm.nih.gov/#4133
type: UnificationXref
db: Entrez Gene
id: 4133

MYO5A
type: Protein
entity reference: MYO5A

CaM.family_inactive
type: Protein

EDN1_inactive
type: Protein
entity reference: EDN1

MYO1B
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4430
organism: Homo sapiens

MAPK3
type: Protein
entity reference: MAPK3

PIP3
type: SmallMolecule
entity reference: PIP3

GPR98
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#84059
organism: Homo sapiens

17353931
type: PublicationXref
title: Large-scale mapping of human protein-protein interactions by mass spectrometry
db: PubMed
id: 17353931

10748187
type: PublicationXref
title: ERK1b, a 46-kDa ERK isoform that is differentially regulated by MEK
db: PubMed
id: 10748187

http://www.ebi.ac.uk/chebi/#16618
type: UnificationXref
db: ChEBI
id: 16618

.CAMKK2.PROMOTES.Complex.AMPK...(PRKAG1).
type: Catalysis
xref: 16054096
xref: 17244528
controlled: Phosphorylation.P.CAMKK2.AMPK
control type: ACTIVATION
data source: Spike
controller: CAMKK2

PRKCD
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5580
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#51168
type: UnificationXref
db: Entrez Gene
id: 51168

PhysicalInteraction [GPR98 -- MYO7A ]
type: MolecularInteraction
participant: GPR98
participant: MYO7A
xref: 17567809

CEBPB
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1051
organism: Homo sapiens

MYOG
type: Protein
entity reference: MYOG

http://www.ncbi.nlm.nih.gov/#64072
type: UnificationXref
db: Entrez Gene
id: 64072

http://www.ncbi.nlm.nih.gov/#65217
type: UnificationXref
db: Entrez Gene
id: 65217

http://www.ncbi.nlm.nih.gov/#10083
type: UnificationXref
db: Entrez Gene
id: 10083

.MAP2K1.PROMOTES.MAPK3.
type: Catalysis
xref: 8626767
xref: 8226933
xref: 10748187
controlled: Phosphorylation.P.MAP2K1.MAPK3
control type: ACTIVATION
data source: Spike
controller: MAP2K1

PhysicalInteraction [CAMK2A -- MYO7A ]
type: MolecularInteraction
participant: MYO7A
participant: CAMK2A
xref: 11171103

RYR2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6262
organism: Homo sapiens

ESPN
type: Protein
entity reference: ESPN

MAPK3_inactive
type: Protein
entity reference: MAPK3

.DAG.PROMOTES.PRKCB.
type: Catalysis
xref: 1411571
controlled: Other.P.DAG.PRKCB
control type: ACTIVATION
data source: Spike
controller: DAG

16301217
type: PublicationXref
title: Usherin, the defective protein in Usher syndrome type IIA, is likely to be a component of interstereocilia ankle links in the inner ear sensory cells
db: PubMed
id: 16301217

MAP2K2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5605
organism: Homo sapiens

DAG
type: SmallMolecule
entity reference: DAG

15590698
type: PublicationXref
title: Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly
db: PubMed
id: 15590698

MAP2
type: Protein
entity reference: MAP2

USH1C
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#10083
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#84059
type: UnificationXref
db: Entrez Gene
id: 84059

17244528
type: PublicationXref
title: Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2
db: PubMed
id: 17244528

GLRX
type: Protein
entity reference: GLRX

.Ca 2+.PROMOTES.PRKCA.
type: Catalysis
xref: 1411571
controlled: N/A.P.Ca 2+.PRKCA
control type: ACTIVATION
data source: Spike
controller: Ca_2+

Glutathione
type: SmallMoleculeReference
xref: http://www.ebi.ac.uk/chebi/#16856

http://www.ncbi.nlm.nih.gov/#5608
type: UnificationXref
db: Entrez Gene
id: 5608

PhysicalInteraction [PCDH15 -- USH1C ]
type: MolecularInteraction
participant: USH1C
participant: PCDH15
xref: 15590703

http://www.ncbi.nlm.nih.gov/#7275
type: UnificationXref
db: Entrez Gene
id: 7275

PRKCA_inactive
type: Protein
entity reference: PRKCA

MYO7A
type: Protein
entity reference: MYO7A

.DAG.PROMOTES.PRKCA.
type: Catalysis
xref: 1411571
controlled: Other.P.DAG.PRKCA
control type: ACTIVATION
data source: Spike
controller: DAG

CDH23
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#64072
organism: Homo sapiens

17050716
type: PublicationXref
title: Stereociliary myosin-1c receptors are sensitive to calcium chelation and absent from cadherin 23 mutant mice
db: PubMed
id: 17050716

CAMK2A
type: Protein
entity reference: CAMK2A

http://www.ncbi.nlm.nih.gov/#124590
type: UnificationXref
db: Entrez Gene
id: 124590

USH1G
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#124590
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#2745
type: UnificationXref
db: Entrez Gene
id: 2745

USH1C
type: Protein
entity reference: USH1C

16206170
type: PublicationXref
title: Balanced levels of Espin are critical for stereociliary growth and length maintenance
db: PubMed
id: 16206170

MYO1E
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4643
organism: Homo sapiens

.Ca 2+.PROMOTES.PRKCB.
type: Catalysis
xref: 1411571
controlled: N/A.P.Ca 2+.PRKCB
control type: ACTIVATION
data source: Spike
controller: Ca_2+

MAP2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4133
organism: Homo sapiens

CALM3
type: Protein
entity reference: CALM3

PhysicalInteraction [USH1C -- USH1G ]
type: MolecularInteraction
participant: USH1G
participant: USH1C
xref: 12588794
xref: 16713569
xref: 17936325

.MAPK3.PROMOTES.CEBPB.
type: Catalysis
xref: 19443782
controlled: Phosphorylation.P.MAPK3.CEBPB
control type: ACTIVATION
data source: Spike
controller: MAPK3

PhysicalInteraction [MAP2 -- MYO7A ]
type: MolecularInteraction
participant: MYO7A
participant: MAP2
xref: 11171103

DAB2
type: Protein
entity reference: DAB2

MAP2K1
type: Protein
entity reference: MAP2K1

DFNB31
type: Protein
entity reference: DFNB31

MYO1C
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4641
organism: Homo sapiens

PhysicalInteraction [CDH23 -- USH1C ]
type: MolecularInteraction
participant: USH1C
participant: CDH23
xref: 16713569
xref: 15590703

PhysicalInteraction [MAP2K6 -- PLCB2 ]
type: MolecularInteraction
participant: MAP2K6
participant: PLCB2
xref: 16189514

ALC.complex
type: Complex
component: USH2A
component: VEZT
component: DFNB31
name: ankle-link molecular complex (ALC)
data source: Spike

PhysicalInteraction [USH2A -- VEZT ]
type: MolecularInteraction
participant: USH2A
participant: VEZT
xref: 17567809

MYO1G
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#64005
organism: Homo sapiens

12588794
type: PublicationXref
title: Usher syndrome type I G (USH1G) is caused by mutations in the gene encoding SANS, a protein that associates with the USH1C protein, harmonin
db: PubMed
id: 12588794

http://www.ncbi.nlm.nih.gov/#1051
type: UnificationXref
db: Entrez Gene
id: 1051

1411571
type: PublicationXref
title: Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
db: PubMed
id: 1411571

11171103
type: PublicationXref
title: Myosin VIIA is specifically associated with calmodulin and microtubule-associated protein-2B (MAP-2B)
db: PubMed
id: 11171103

16713569
type: PublicationXref
title: A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
db: PubMed
id: 16713569

19114066
type: PublicationXref
title: Molecular mechanisms underlying cochlear degeneration in the tubby mouse and the therapeutic effect of sulforaphane
db: PubMed
id: 19114066

CDH23
type: Protein
entity reference: CDH23

15037754
type: PublicationXref
title: The unique insert in myosin VI is a structural calcium-calmodulin binding site
db: PubMed
id: 15037754

MYO1F
type: Protein
entity reference: MYO1F

MYO1A
type: Protein
entity reference: MYO1A

http://www.ebi.ac.uk/chebi/#16856
type: UnificationXref
db: ChEBI
id: 16856

RYR2_inactive
type: Protein
entity reference: RYR2

GAPDH
type: Protein
entity reference: GAPDH

.GLRX.INHIBITS.GAPDH.
type: Catalysis
xref: 12556467
controlled: S.glutathionylation.I.GLRX.GAPDH
control type: INHIBITION
data source: Spike
controller: GLRX

.Ca 2+.PROMOTES.RYR2.
type: Catalysis
xref: 11483514
controlled: Other.P.Ca 2+.RYR2
control type: ACTIVATION
data source: Spike
controller: Ca_2+

http://www.ncbi.nlm.nih.gov/#3091
type: UnificationXref
db: Entrez Gene
id: 3091

MYO1B
type: Protein
entity reference: MYO1B

EDN1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1906
organism: Homo sapiens

MYO1G
type: Protein
entity reference: MYO1G

http://www.ncbi.nlm.nih.gov/#2597
type: UnificationXref
db: Entrez Gene
id: 2597

http://www.ncbi.nlm.nih.gov/#283446
type: UnificationXref
db: Entrez Gene
id: 283446

http://www.ncbi.nlm.nih.gov/#1601
type: UnificationXref
db: Entrez Gene
id: 1601

11080149
type: PublicationXref
title: Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex
db: PubMed
id: 11080149

18160714
type: PublicationXref
title: Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia
db: PubMed
id: 18160714

TUB
type: Protein
entity reference: TUB

PhysicalInteraction [GIPC1 -- MYO6 ]
type: MolecularInteraction
participant: MYO6
participant: GIPC1
xref: 17187061
xref: 17145710
xref: 17353931
comment: intact:EBI-1064920,intact:EBI-1064920

CaM.family
type: Protein
xref: WSC:F.000002
data source: Spike
member physical entity: CALM2
member physical entity: CALM1
member physical entity: CALM3

PIP3_inactive
type: Protein

.MAPK3.PROMOTES.SHC1.
type: Catalysis
xref: 15930121
controlled: Phosphorylation.P.MAPK3.SHC1
control type: ACTIVATION
data source: Spike
controller: MAPK3

ACTA1
type: Protein
entity reference: ACTA1

VEZT
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#55591
organism: Homo sapiens

8226933
type: PublicationXref
title: Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases
db: PubMed
id: 8226933

http://www.ncbi.nlm.nih.gov/#5604
type: UnificationXref
db: Entrez Gene
id: 5604

http://www.ncbi.nlm.nih.gov/#5605
type: UnificationXref
db: Entrez Gene
id: 5605

WSC:F.000002
type: UnificationXref
db: Spike DB
id: WSC:F-000002

PIP3
type: SmallMoleculeReference
xref: http://www.ebi.ac.uk/chebi/#16618

.PI(4,5)P2.PROMOTES.DAG.
type: Catalysis
xref: 1411571
controlled: N/A.P.PI(4,5)P2.DAG
control type: ACTIVATION
data source: Spike
controller: PI(4,5)P2

CAMK2A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#815
organism: Homo sapiens

USH1G
type: Protein
entity reference: USH1G

11955428
type: PublicationXref
title: Calmodulin in action: diversity in target recognition and activation mechanisms
db: PubMed
id: 11955428

MYO1E
type: Protein
entity reference: MYO1E

CALM2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#805
organism: Homo sapiens

DAG
type: SmallMoleculeReference
xref: http://www.ebi.ac.uk/chebi/#18035

.GAPDH.INHIBITS.EDN1.
type: Catalysis
xref: 18809573
controlled: Other.I.GAPDH.EDN1
control type: INHIBITION
data source: Spike
controller: GAPDH

DAB2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1601
organism: Homo sapiens

16887817
type: PublicationXref
title: Requirement for Map2k1 (Mek1) in extra-embryonic ectoderm during placentogenesis
db: PubMed
id: 16887817

PhysicalInteraction [DAB2 -- MYO6 ]
type: MolecularInteraction
participant: MYO6
participant: DAB2
xref: 11967127
xref: 16713569
xref: 11906161

MYO1D
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4642
organism: Homo sapiens

PRKCB
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5579
organism: Homo sapiens

SHC1_inactive
type: Protein
entity reference: SHC1

PhysicalInteraction [DFNB31 -- USH2A ]
type: MolecularInteraction
participant: USH2A
participant: DFNB31
xref: 16301217

CAMKK2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#10645
organism: Homo sapiens

MAGI1
type: Protein
entity reference: MAGI1

MYO15A_inactive
type: Protein
entity reference: MYO15A

.Ca 2+.PROMOTES.Family.CaM..CALM3,.CALM1,.CALM2.(CALM3).
type: Catalysis
xref: 11955428
controlled: Physical.Interaction.P.Ca 2+.CaM
control type: ACTIVATION
data source: Spike
controller: Ca_2+

11238443
type: PublicationXref
title: Stress-induced inhibition of ERK1 and ERK2 by direct interaction with p38 MAP kinase
db: PubMed
id: 11238443

PRKCD_inactive
type: Protein
entity reference: PRKCD

.MAP2K2.PROMOTES.MAPK3.
type: Catalysis
xref: 11251083
xref: 16887817
xref: 8226933
controlled: Phosphorylation.P.MAP2K2.MAPK3
control type: ACTIVATION
data source: Spike
controller: MAP2K2

CALM3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#808
organism: Homo sapiens

PLCB2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5330
organism: Homo sapiens

PhysicalInteraction [MYO7A -- USH2A ]
type: MolecularInteraction
participant: USH2A
participant: MYO7A
xref: 16301217
xref: 17567809

12556467
type: PublicationXref
title: Glutathione-thiyl radical scavenging and transferase properties of human glutaredoxin (thioltransferase). Potential role in redox signal transduction
db: PubMed
id: 12556467

ACTA1_inactive
type: Protein
entity reference: ACTA1

PLCB2
type: Protein
entity reference: PLCB2

PhysicalInteraction [MYO7A -- VEZT ]
type: MolecularInteraction
participant: VEZT
participant: MYO7A
xref: 11080149

CEBPB_inactive
type: Protein
entity reference: CEBPB

http://www.ncbi.nlm.nih.gov/#10755
type: UnificationXref
db: Entrez Gene
id: 10755

GAPDH
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2597
organism: Homo sapiens

18971469
type: PublicationXref
title: MAGI-1, a candidate stereociliary scaffolding protein, associates with the tip-link component cadherin 23
db: PubMed
id: 18971469

MAPK3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5595
organism: Homo sapiens

15654330
type: PublicationXref
title: Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia
db: PubMed
id: 15654330

MYO3A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#53904
organism: Homo sapiens

Homo sapiens
type: BioSource
xref: 9606

PI(4,5)P2
type: SmallMoleculeReference
xref: http://www.ebi.ac.uk/chebi/#18348

.PI(4,5)P2.PROMOTES.Ca 2+.
type: Catalysis
xref: 1411571
controlled: N/A.P.PI(4,5)P2.Ca 2+
control type: ACTIVATION
data source: Spike
controller: PI(4,5)P2

.DAG.PROMOTES.PRKCD.
type: Catalysis
xref: 1411571
controlled: Other.P.DAG.PRKCD
control type: ACTIVATION
data source: Spike
controller: DAG

DAG_inactive
type: Protein

ACTA1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#58
organism: Homo sapiens

MAP2K1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5604
organism: Homo sapiens

8626767
type: PublicationXref
title: Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2
db: PubMed
id: 8626767

GPCR.family
type: Protein
xref: TAU:F.329932
data source: Spike
member physical entity: DFNB31

http://www.ncbi.nlm.nih.gov/#4430
type: UnificationXref
db: Entrez Gene
id: 4430

PI(4,5)P2
type: SmallMolecule
entity reference: PI(4,5)P2

18809573
type: PublicationXref
title: Glyceraldehyde-3-phosphate dehydrogenase regulates endothelin-1 expression by a novel, redox-sensitive mechanism involving mRNA stability
db: PubMed
id: 18809573

19443782
type: PublicationXref
title: MAPK3/1 (ERK1/2) in ovarian granulosa cells are essential for female fertility
db: PubMed
id: 19443782

16169070
type: PublicationXref
title: A human protein-protein interaction network: a resource for annotating the proteome
db: PubMed
id: 16169070

GLRX
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2745
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#815
type: UnificationXref
db: Entrez Gene
id: 815

http://www.ncbi.nlm.nih.gov/#64005
type: UnificationXref
db: Entrez Gene
id: 64005

9606
type: UnificationXref
db: taxonomy
id: 9606

Ca_2+
type: SmallMoleculeReference
xref: http://www.ebi.ac.uk/chebi/#29108

http://www.ncbi.nlm.nih.gov/#83715
type: UnificationXref
db: Entrez Gene
id: 83715

Myo.family
type: Protein
xref: TAU:F.329934
data source: Spike
member physical entity: MYO1G
member physical entity: MYOG
member physical entity: MYO1E
member physical entity: MYO1F
member physical entity: MYO1A
member physical entity: MYO5A
member physical entity: MYO1C
member physical entity: MYO7A
member physical entity: MYO6
member physical entity: MYO3A
member physical entity: MYO1H
member physical entity: MYO1D
member physical entity: MYO15A
member physical entity: MYO1B

.MAPK3.PROMOTES.HIF1A.
type: Catalysis
xref: 10551817
controlled: Phosphorylation.P.MAPK3.HIF1A
control type: ACTIVATION
data source: Spike
controller: MAPK3

http://www.ncbi.nlm.nih.gov/#1432
type: UnificationXref
db: Entrez Gene
id: 1432

.GPR98.PROMOTES.DFNB31.
type: Catalysis
xref: 17567809
controlled: Other.P.GPR98.DFNB31
control type: ACTIVATION
data source: Spike
controller: GPR98

http://www.ncbi.nlm.nih.gov/#10645
type: UnificationXref
db: Entrez Gene
id: 10645

11906161
type: PublicationXref
title: DOC-2/DAB2 is the binding partner of myosin VI
db: PubMed
id: 11906161

http://www.ncbi.nlm.nih.gov/#5595
type: UnificationXref
db: Entrez Gene
id: 5595

SHC1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6464
organism: Homo sapiens

MYO15A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#51168
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#801
type: UnificationXref
db: Entrez Gene
id: 801

http://www.ncbi.nlm.nih.gov/#808
type: UnificationXref
db: Entrez Gene
id: 808

19074803
type: PublicationXref
title: Stimulatory role of PKCalpha in extracellular regulated kinase 1/2 pathway in conjunctival goblet cell proliferation
db: PubMed
id: 19074803

http://www.ncbi.nlm.nih.gov/#805
type: UnificationXref
db: Entrez Gene
id: 805

17145710
type: PublicationXref
title: IntAct--open source resource for molecular interaction data
db: PubMed
id: 17145710

http://www.ncbi.nlm.nih.gov/#58
type: UnificationXref
db: Entrez Gene
id: 58

MYO3A
type: Protein
entity reference: MYO3A

MYO1H
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#283446
organism: Homo sapiens

MYO1D
type: Protein
entity reference: MYO1D

PhysicalInteraction [MYO7A -- USH1G ]
type: MolecularInteraction
participant: USH1G
participant: MYO7A
xref: 15590703

http://www.ncbi.nlm.nih.gov/#6262
type: UnificationXref
db: Entrez Gene
id: 6262

.GLRX.PROMOTES.ACTA1.
type: Catalysis
xref: 12556467
controlled: S.glutathionylation.P.GLRX.ACTA1
control type: ACTIVATION
data source: Spike
controller: GLRX

HIF1A
type: Protein
entity reference: HIF1A

CAMKK2
type: Protein
entity reference: CAMKK2

MAPK14
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1432
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#5580
type: UnificationXref
db: Entrez Gene
id: 5580

PhysicalInteraction [CDH23 -- MAGI1 ]
type: MolecularInteraction
participant: MAGI1
participant: CDH23
xref: 18971469

HIF1A_inactive
type: Protein
entity reference: HIF1A

http://www.ebi.ac.uk/chebi/#29108
type: UnificationXref
db: ChEBI
id: 29108

MAPK14
type: Protein
entity reference: MAPK14

http://www.ncbi.nlm.nih.gov/#6464
type: UnificationXref
db: Entrez Gene
id: 6464

CAMKK2_inactive
type: Protein
entity reference: CAMKK2

USH2A
type: Protein
entity reference: USH2A

http://www.ncbi.nlm.nih.gov/#4542
type: UnificationXref
db: Entrez Gene
id: 4542

http://www.ncbi.nlm.nih.gov/#5579
type: UnificationXref
db: Entrez Gene
id: 5579

http://www.ncbi.nlm.nih.gov/#5578
type: UnificationXref
db: Entrez Gene
id: 5578

HIF1A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3091
organism: Homo sapiens

PhysicalInteraction [ACTA1 -- MYO7A ]
type: MolecularInteraction
participant: MYO7A
participant: ACTA1
xref: 18160714

15930121
type: PublicationXref
title: ERK phosphorylates p66shcA on Ser36 and subsequently regulates p27kip1 expression via the Akt-FOXO3a pathway: implication of p27kip1 in cell response to oxidative stress
db: PubMed
id: 15930121

PRKCB_inactive
type: Protein
entity reference: PRKCB

PhysicalInteraction [CALM2 -- MYO6 ]
type: MolecularInteraction
participant: CALM2
participant: MYO6
xref: 15037754
xref: 16169070

MYO1F
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4542
organism: Homo sapiens

PhysicalInteraction [MYO7A -- USH1C ]
type: MolecularInteraction
participant: USH1C
participant: MYO7A
xref: 17567809
xref: 16713569

11967127
type: PublicationXref
title: Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton
db: PubMed
id: 11967127

CALM1
type: Protein
entity reference: CALM1

MYO1C
type: Protein
entity reference: MYO1C

PCDH15
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#65217
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#1906
type: UnificationXref
db: Entrez Gene
id: 1906

Ca_2+_inactive
type: Protein

16189514
type: PublicationXref
title: Towards a proteome-scale map of the human protein-protein interaction network
db: PubMed
id: 16189514

PRKCA
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5578
organism: Homo sapiens

TUB
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7275
organism: Homo sapiens

11251083
type: PublicationXref
title: Mechanism in the sequential control of cell morphology and S phase entry by epidermal growth factor involves distinct MEK/ERK activations
db: PubMed
id: 11251083

17187061
type: PublicationXref
title: Myosin VI targeting to clathrin-coated structures and dimerization is mediated by binding to Disabled-2 and PtdIns(4,5)P2
db: PubMed
id: 17187061

16054096
type: PublicationXref
title: Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells
db: PubMed
id: 16054096

MYO6
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4646
organism: Homo sapiens

Glutathione
type: SmallMolecule
entity reference: Glutathione

.ESPN.PROMOTES.MYO15A.
type: Catalysis
xref: 16206170
controlled: N/A.P.ESPN.MYO15A
control type: ACTIVATION
data source: Spike
controller: ESPN

VEZT
type: Protein
entity reference: VEZT

17567809
type: PublicationXref
title: Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning
db: PubMed
id: 17567809

.PLCB2.PROMOTES.PI(4,5)P2.
type: Catalysis
xref: 1411571
controlled: N/A.P.PLCB2.PI(4,5)P2
control type: ACTIVATION
data source: Spike
controller: PLCB2

MYO6
type: Protein
entity reference: MYO6

ESPN
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#83715
organism: Homo sapiens

Ca_2+
type: SmallMolecule
entity reference: Ca_2+

MAP2K6
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5608
organism: Homo sapiens

MYO15A
type: Protein
entity reference: MYO15A

GIPC1
type: Protein
entity reference: GIPC1

PRKCB
type: Protein
entity reference: PRKCB

1851250
type: PublicationXref
title: Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils
db: PubMed
id: 1851250

GPR98
type: Protein
entity reference: GPR98

MAP2K2
type: Protein
entity reference: MAP2K2

Spike
type: Provenance

MAGI1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#9223
organism: Homo sapiens

.Glutathione.INHIBITS.GAPDH.
type: Catalysis
xref: 18809573
controlled: S.glutathionylation.I.Glutathione.GAPDH
control type: INHIBITION
data source: Spike
controller: Glutathione

.Complex.Ca/CaM..Ca 2+,.Family.CaM..CALM3,.CALM1,.CALM2...PROMOTES.CAMKK2.
type: Catalysis
xref: 11395482
controlled: Physical.Interaction.P.Ca/CaM.CAMKK2
control type: ACTIVATION
data source: Spike
controller: Ca/CaM.complex

MYOG
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4656
organism: Homo sapiens

15590703
type: PublicationXref
title: Interactions in the network of Usher syndrome type 1 proteins
db: PubMed
id: 15590703

2549071
type: PublicationXref
title: Transient increase in phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol trisphosphate during activation of human neutrophils
db: PubMed
id: 2549071

CEBPB
type: Protein
entity reference: CEBPB

.GPR98.PROMOTES.USH2A.
type: Catalysis
xref: 17567809
controlled: Other.P.GPR98.USH2A
control type: ACTIVATION
data source: Spike
controller: GPR98

DFNB31_inactive
type: Protein
entity reference: DFNB31

MYO7A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4647
organism: Homo sapiens

.PI(4,5)P2.PROMOTES.PIP3.
type: Catalysis
xref: 1851250
xref: 2549071
controlled: Other.P.PI(4,5)P2.PIP3
control type: ACTIVATION
data source: Spike
controller: PI(4,5)P2

.MYO15A.PROMOTES.DFNB31.
type: Catalysis
xref: 15654330
controlled: Physical.Interaction.P.MYO15A.DFNB31
control type: ACTIVATION
data source: Spike
controller: MYO15A

http://www.ncbi.nlm.nih.gov/#55591
type: UnificationXref
db: Entrez Gene
id: 55591

MYO5A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4644
organism: Homo sapiens

MYO1A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4640
organism: Homo sapiens

PhysicalInteraction [DFNB31 -- MYO7A ]
type: MolecularInteraction
participant: MYO7A
participant: DFNB31
xref: 15590698

17936325
type: PublicationXref
title: Usher syndrome: animal models, retinal function of Usher proteins, and prospects for gene therapy
db: PubMed
id: 17936325

PhysicalInteraction [CDH23 -- MYO1C ]
type: MolecularInteraction
participant: MYO1C
participant: CDH23
xref: 17050716

http://www.ncbi.nlm.nih.gov/#53904
type: UnificationXref
db: Entrez Gene
id: 53904

PRKCA
type: Protein
entity reference: PRKCA

http://www.ebi.ac.uk/chebi/#18348
type: UnificationXref
db: ChEBI
id: 18348

RYR2
type: Protein
entity reference: RYR2

USH2A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7399
organism: Homo sapiens

SHC1
type: Protein
entity reference: SHC1

http://www.ncbi.nlm.nih.gov/#9223
type: UnificationXref
db: Entrez Gene
id: 9223

PI(4,5)P2_inactive
type: Protein

.GPR98.PROMOTES.VEZT.
type: Catalysis
xref: 17567809
controlled: Other.P.GPR98.VEZT
control type: ACTIVATION
data source: Spike
controller: GPR98

CALM1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#801
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#4656
type: UnificationXref
db: Entrez Gene
id: 4656

PhysicalInteraction [CALM1 -- MYO6 ]
type: MolecularInteraction
participant: CALM1
participant: MYO6
xref: 17145710
xref: 15037754
comment: intact:EBI-734105

http://www.ebi.ac.uk/chebi/#18035
type: UnificationXref
db: ChEBI
id: 18035

10551817
type: PublicationXref
title: p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1
db: PubMed
id: 10551817

11395482
type: PublicationXref
title: Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity
db: PubMed
id: 11395482

USH2A_inactive
type: Protein
entity reference: USH2A

http://www.ncbi.nlm.nih.gov/#25861
type: UnificationXref
db: Entrez Gene
id: 25861

.MAPK14.INHIBITS.MAPK3.
type: Catalysis
xref: 11238443
controlled: Physical.Interaction.I.MAPK14.MAPK3
control type: INHIBITION
data source: Spike
controller: MAPK14

PRKCD
type: Protein
entity reference: PRKCD

AMPK.complex_inactive
type: Protein

MAP2K6
type: Protein
entity reference: MAP2K6

.PRKCA.PROMOTES.MAPK3.
type: Catalysis
xref: 19074803
controlled: Indirect.P.PRKCA.MAPK3
control type: ACTIVATION
data source: Spike
controller: PRKCA

11483514
type: PublicationXref
title: Propagation of the apoptotic signal by mitochondrial waves
db: PubMed
id: 11483514

TAU:F.329932
type: UnificationXref
db: Spike DB
id: TAU:F-329932

CALM2
type: Protein
entity reference: CALM2

TAU:F.329934
type: UnificationXref
db: Spike DB
id: TAU:F-329934

http://www.ncbi.nlm.nih.gov/#4640
type: UnificationXref
db: Entrez Gene
id: 4640

PhysicalInteraction [CALM1 -- MYO1C ]
type: MolecularInteraction
participant: MYO1C
participant: CALM1
xref: 17050716

DFNB31
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#25861
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#4647
type: UnificationXref
db: Entrez Gene
id: 4647

VEZT_inactive
type: Protein
entity reference: VEZT

GIPC1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#10755
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#4646
type: UnificationXref
db: Entrez Gene
id: 4646

http://www.ncbi.nlm.nih.gov/#5330
type: UnificationXref
db: Entrez Gene
id: 5330

http://www.ncbi.nlm.nih.gov/#4643
type: UnificationXref
db: Entrez Gene
id: 4643

MYO1H
type: Protein
entity reference: MYO1H

http://www.ncbi.nlm.nih.gov/#4644
type: UnificationXref
db: Entrez Gene
id: 4644

Ca/CaM.complex
type: Complex
component: Ca_2+
component: CaM.family
name: Calcium-Calmodulin complex
data source: Spike

http://www.ncbi.nlm.nih.gov/#4641
type: UnificationXref
db: Entrez Gene
id: 4641

http://www.ncbi.nlm.nih.gov/#4642
type: UnificationXref
db: Entrez Gene
id: 4642