BMP4
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#652

TGFB1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7040

.APC.INHIBITS.CTNNB1.
type: Catalysis
controlled: Physical.Interaction.I.APC.CTNNB1
control type: INHIBITION
controller: APC
data source: Spike
xref: 16798748

http://www.ncbi.nlm.nih.gov/#7471
type: UnificationXref
id: 7471
db: Entrez Gene

.STAT3.PROMOTES.BCL2L1.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.STAT3.BCL2L1
data source: Spike
controller: STAT3
xref: 11994401

15951851
type: PublicationXref
id: 15951851
db: PubMed
title: The multiple personalities of the regulatory subunit of protein kinase CK2: CK2 dependent and CK2 independent roles reveal a secret identity for CK2beta

TP53_DNA
type: DnaRegion
entity reference: TP53

.SIX1.PROMOTES.PAX2.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.SIX1.PAX2
data source: Spike
controller: SIX1
xref: 17035528

PhysicalInteraction [Complex CK2 {} -- FGF1 ]
type: MolecularInteraction
participant: Caseine Kinase 2
participant: FGF1
xref: 12396231

.BCL2.INHIBITS.BAX.
type: Catalysis
controlled: Other.I.BCL2.BAX
control type: INHIBITION
controller: BCL2
data source: Spike
xref: 8358790
xref: 9463381
xref: 9111042

FOXI1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2299

PAX3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5077

CDKN1A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1026

Translation
type: MolecularInteraction
participant: BCL2L1_inactive
participant: BCL2L1_RNA

http://www.ncbi.nlm.nih.gov/#2625
type: UnificationXref
id: 2625
db: Entrez Gene

PARP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#142

http://www.ncbi.nlm.nih.gov/#1387
type: UnificationXref
id: 1387
db: Entrez Gene

BCL2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#596

LFNG
type: Protein
entity reference: LFNG

http://www.ncbi.nlm.nih.gov/#1386
type: UnificationXref
id: 1386
db: Entrez Gene

.SIX1.PROMOTES.GATA3.
type: Catalysis
controlled: Dephosphorylation.P.SIX1.GATA3
control type: ACTIVATION
controller: SIX1
data source: Spike
xref: 12874121

FGFR3
type: Protein
entity reference: FGFR3

EYA1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2138

Translation
type: MolecularInteraction
participant: JAG1_RNA
participant: JAG1_inactive

DACH1
type: Protein
entity reference: DACH1

CDKN1B
type: Protein
entity reference: CDKN1B

PhysicalInteraction [Complex CK2 {} -- FGF2 ]
type: MolecularInteraction
participant: FGF2
participant: Caseine Kinase 2
xref: 12396231

11994401
type: PublicationXref
id: 11994401
db: PubMed
title: Stat proteins and oncogenesis

.EGR1.PROMOTES.TP53.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.EGR1.TP53
data source: Spike
controller: EGR1
xref: 12384981

8900201
type: PublicationXref
id: 8900201
db: PubMed
title: The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32

TGFB1_RNA
type: RnaRegion
entity reference: TGFB1

.Complex.CK2....PROMOTES.TP53.
type: Catalysis
controlled: Phosphorylation.P.CK2.TP53
control type: ACTIVATION
controller: Caseine Kinase 2
data source: Spike
xref: 15951851

HSP90-CDC37 chaperone complex
type: Complex
data source: Spike
component: CDC37
display name: HSP90-CDC37.complex

MAF_DNA
type: DnaRegion
entity reference: MAF

JUN_inactive
type: Protein
entity reference: JUN

DLX5_DNA
type: DnaRegion
entity reference: DLX5

.EGR1.PROMOTES.PDGFA.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.EGR1.PDGFA
data source: Spike
controller: EGR1
xref: 12384981

FGFR3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2261

Ternary Complex Factor
type: Complex
data source: Spike
display name: TCF.complex

http://www.ncbi.nlm.nih.gov/#26281
type: UnificationXref
id: 26281
db: Entrez Gene

Translation
type: MolecularInteraction
participant: OTX1_RNA
participant: OTX1

HES1_inactive
type: Protein
entity reference: HES1

APC_DNA
type: DnaRegion
entity reference: APC

.BAD.INHIBITS.BCL2.
type: Catalysis
controlled: Physical.Interaction.I.BAD.BCL2
control type: INHIBITION
controller: BAD
data source: Spike
xref: 11583631
xref: 11483855
xref: 9463381
xref: 7834748

16251211
type: PublicationXref
id: 16251211
db: PubMed
title: Homeotic factor ATBF1 induces the cell cycle arrest associated with neuronal differentiation

GSN
type: Protein
entity reference: GSN

CASP6
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#839

http://www.ncbi.nlm.nih.gov/#9518
type: UnificationXref
id: 9518
db: Entrez Gene

ESR1
type: Protein
entity reference: ESR1

.STAT1.PROMOTES.CDKN1A.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.STAT1.CDKN1A
data source: Spike
controller: STAT1
xref: 17992189

18259074
type: PublicationXref
id: 18259074
db: PubMed
title: Progressive hearing loss in mice with a mutated vitamin D receptor gene

LEF/TCF-BETA CATENIN.complex_inactive
type: Protein

.Family.mir.17....INHIBITS.STAT3.
type: Catalysis
controlled: N/A.I.mir.17.STAT3
control type: INHIBITION
controller: mir-17.family
data source: Spike
xref: 19073166

Translation
type: MolecularInteraction
participant: Protein kinase, cAMP-dependent
participant: PKA (PRKA).complex_RNA

OTX1
type: Protein
entity reference: OTX1

Translation
type: MolecularInteraction
participant: CTNNB1_RNA
participant: CTNNB1_inactive

MAF_RNA
type: RnaRegion
entity reference: MAF

CASP6
type: Protein
entity reference: CASP6

16495313
type: PublicationXref
id: 16495313
db: PubMed
title: Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear

CTNNB1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1499

16798748
type: PublicationXref
id: 16798748
db: PubMed
title: Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells

BMP4_DNA
type: DnaRegion
entity reference: BMP4

DLX5
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1749

17312100
type: PublicationXref
id: 17312100
db: PubMed
title: The JAK-STAT signaling pathway: input and output integration

FGFR2
type: Protein
entity reference: FGFR2

CASP7
type: Protein
entity reference: CASP7

Translation
type: MolecularInteraction
participant: EGFR_RNA
participant: EGFR

DACH2_DNA
type: DnaRegion
entity reference: DACH2

STAT3
type: Protein
entity reference: STAT3

http://www.ncbi.nlm.nih.gov/#2934
type: UnificationXref
id: 2934
db: Entrez Gene

BCL2L1
type: Protein
entity reference: BCL2L1

CDKN1B_RNA
type: RnaRegion
entity reference: CDKN1B

OTX2
type: Protein
entity reference: OTX2

EGFR
type: Protein
entity reference: EGFR

PDGF.family
type: Protein
data source: Spike
member physical entity: PDGFA
xref: ELK:F.329918

http://www.ncbi.nlm.nih.gov/#2637
type: UnificationXref
id: 2637
db: Entrez Gene

Translation
type: MolecularInteraction
participant: FGF3_inactive
participant: FGF3_RNA

Translation
type: MolecularInteraction
participant: DLX5_inactive
participant: DLX5_RNA

http://www.ncbi.nlm.nih.gov/#1499
type: UnificationXref
id: 1499
db: Entrez Gene

PAX8
type: Protein
entity reference: PAX8

LFNG
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3955

CTNNB1
type: Protein
entity reference: CTNNB1

BCL2L1_RNA
type: RnaRegion
entity reference: BCL2L1

OTX2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5015

SIX1_DNA
type: DnaRegion
entity reference: SIX1

PDGFA
type: Protein
entity reference: PDGFA

APC_RNA
type: RnaRegion
entity reference: APC

.CASP3.INHIBITS.XIAP.
type: Catalysis
controlled: Protein.Degradation.I.CASP3.XIAP
control type: INHIBITION
controller: CASP3
data source: Spike
xref: 15725726

.STAT6.PROMOTES.ARG1.
type: Catalysis
controlled: Translational.Regulation.P.STAT6.ARG1
control type: ACTIVATION
controller: STAT6
data source: Spike
xref: 17312100

TNFRSF1B
type: Protein
entity reference: TNFRSF1B

11437602
type: PublicationXref
id: 11437602
db: PubMed
title: [W206R]-procaspase 3: an inactivatable substrate for caspase 8

CASP9_inactive
type: Protein
entity reference: CASP9

Translation
type: MolecularInteraction
participant: NFE2L2_RNA
participant: NFE2L2_inactive

BAD
type: Protein
entity reference: BAD

Translation
type: MolecularInteraction
participant: TP53_inactive
participant: TP53_RNA

http://www.ncbi.nlm.nih.gov/#7157
type: UnificationXref
id: 7157
db: Entrez Gene

.MAPK8.PROMOTES.BID.
type: Catalysis
controlled: N/A.P.MAPK8.BID
control type: ACTIVATION
controller: MAPK8
data source: Spike
xref: 18594987

.EGR1.PROMOTES.ID3.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.EGR1.ID3
data source: Spike
controller: EGR1
xref: 12165491

http://www.ncbi.nlm.nih.gov/#7849
type: UnificationXref
id: 7849
db: Entrez Gene

.NOTCH1.PROMOTES.PAX8.
type: Catalysis
controlled: Other.P.NOTCH1.PAX8
control type: ACTIVATION
controller: NOTCH1
data source: Spike
xref: 18495817

http://www.ncbi.nlm.nih.gov/#3725
type: UnificationXref
id: 3725
db: Entrez Gene

BID
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#637

SIX1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6495

STAT1_inactive
type: Protein
entity reference: STAT1

18594987
type: PublicationXref
id: 18594987
db: PubMed
title: Involvement of JNK regulation in oxidative stress-mediated murine liver injury by microcystin-LR

OTX2_DNA
type: DnaRegion
entity reference: OTX2

PAX6
type: Protein
entity reference: PAX6

EGFR
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1956

.TP53.PROMOTES.GDF15.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.TP53.GDF15
data source: Spike
controller: TP53
xref: 17276395

DACH2_RNA
type: RnaRegion
entity reference: DACH2

17185372
type: PublicationXref
id: 17185372
db: PubMed
title: Gonadotropin-releasing hormone couples to 3',5'-cyclic adenosine-5'-monophosphate pathway through novel protein kinase Cdelta and -epsilon in LbetaT2 gonadotrope cells

http://www.ncbi.nlm.nih.gov/#652
type: UnificationXref
id: 652
db: Entrez Gene

.SIX1.INHIBITS.HMX3.
type: Catalysis
controlled: Translational.Regulation.I.SIX1.HMX3
control type: INHIBITION
controller: SIX1
data source: Spike
xref: 14695375

.WNT1.PROMOTES.HES1.
type: Catalysis
controlled: Other.P.WNT1.HES1
control type: ACTIVATION
controller: WNT1
data source: Spike
xref: 18495817

CDKN1C
type: Protein
entity reference: CDKN1C

GSN_inactive
type: Protein
entity reference: GSN

BAX
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#581

.Family.mir.17....INHIBITS.CDKN1A.
type: Catalysis
controlled: N/A.I.mir.17.CDKN1A
control type: INHIBITION
controller: mir-17.family
data source: Spike
xref: 18212054
xref: 18328430

NOTCH1_RNA
type: RnaRegion
entity reference: NOTCH1

18619531
type: PublicationXref
id: 18619531
db: PubMed
title: Identification of phosphorylation sites on transcription factor Sp1 in response to DNA damage and its accumulation at damaged sites

TNFRSF1B
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7133

CDKN1C
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1028

CDC37
type: Protein
entity reference: CDC37

CASP8
type: Protein
entity reference: CASP8

.APC.INHIBITS.Complex.LEF/TCF.BETA.CATENIN...(CTNNB1).
type: Catalysis
controlled: Physical.Interaction.I.APC.LEF/TCF.BETA.CATENIN
control type: INHIBITION
controller: APC
data source: Spike
xref: 9065401

.SIX1.PROMOTES.OTX1.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.SIX1.OTX1
data source: Spike
controller: SIX1
xref: 14695375

TNFRSF1A-RIPK1 INDUCED NOX1
type: Complex
data source: Spike
component: RAC1
component: TNF
component: TRADD
display name: TNFR1.complex

.SIX1.INHIBITS.DACH2.
type: TemplateReactionRegulation
control type: INHIBITION
controlled: Transcription.Regulation.I.SIX1.DACH2
data source: Spike
controller: SIX1
xref: 14695375

ATM
type: Protein
entity reference: ATM

.WNT1.PROMOTES.SOX9.
type: Catalysis
controlled: Other.P.WNT1.SOX9
control type: ACTIVATION
controller: WNT1
data source: Spike
xref: 18495817

19931527
type: PublicationXref
id: 19931527
db: PubMed
title: Recent developments in our understanding of how platelet-derived growth factor (PDGF) and its receptors contribute to proliferative vitreoretinopathy

NOTCH1_DNA
type: DnaRegion
entity reference: NOTCH1

11369511
type: PublicationXref
id: 11369511
db: PubMed
title: Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.

PAX6
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5080

NTRK2_RNA
type: RnaRegion
entity reference: NTRK2

DLX5_RNA
type: RnaRegion
entity reference: DLX5

.SIX1.INHIBITS.DLX5.
type: TemplateReactionRegulation
control type: INHIBITION
controlled: Transcription.Regulation.I.SIX1.DLX5
data source: Spike
controller: SIX1
xref: 14695375

PAK.family
type: Protein
data source: Spike
xref: ELK:F.329923

BCL2_RNA
type: RnaRegion
entity reference: BCL2

http://www.ncbi.nlm.nih.gov/#1749
type: UnificationXref
id: 1749
db: Entrez Gene

.SIX1.INHIBITS.DACH1.
type: TemplateReactionRegulation
control type: INHIBITION
controlled: Transcription.Regulation.I.SIX1.DACH1
data source: Spike
controller: SIX1
xref: 14695375

.SIX1.PROMOTES.OTX2.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.SIX1.OTX2
data source: Spike
controller: SIX1
xref: 14695375

FGF1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2246

BCL2L1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#598

9348292
type: PublicationXref
id: 9348292
db: PubMed
title: Dismantling cell-cell contacts during apoptosis is coupled to a caspase-dependent proteolytic cleavage of beta-catenin

.CASP3.PROMOTES.GSN.
type: Catalysis
controlled: Proteolytic.Processing.P.CASP3.GSN
control type: ACTIVATION
controller: CASP3
data source: Spike
xref: 9323209
xref: 9930654

http://www.ncbi.nlm.nih.gov/#7040
type: UnificationXref
id: 7040
db: Entrez Gene

.NEUROD1.PROMOTES.CDKN1A.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NEUROD1.CDKN1A
data source: Spike
controller: NEUROD1
xref: 16251211

http://www.ncbi.nlm.nih.gov/#4851
type: UnificationXref
id: 4851
db: Entrez Gene

STAT6
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6778

EGFR_DNA
type: DnaRegion
entity reference: EGFR

IGF2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3481

STAT3_inactive
type: Protein
entity reference: STAT3

Translation
type: MolecularInteraction
participant: FOS_RNA
participant: FOS

TGFB1
type: Protein
entity reference: TGFB1

ATF2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1386

PAX.family
type: Protein
data source: Spike
member physical entity: PAX6
member physical entity: PAX2
member physical entity: PAX8
member physical entity: PAX3
xref: TAU:F.329931

TP53_inactive
type: Protein
entity reference: TP53

.NOTCH1.PROMOTES.WNT1.
type: Catalysis
controlled: Other.P.NOTCH1.WNT1
control type: ACTIVATION
controller: NOTCH1
data source: Spike
xref: 18495817

http://www.ncbi.nlm.nih.gov/#2099
type: UnificationXref
id: 2099
db: Entrez Gene

Homo sapiens
type: BioSource
xref: 9606

.CASP3.INHIBITS.PARP1.
type: Catalysis
controlled: Proteolytic.Processing.I.CASP3.PARP1
control type: INHIBITION
controller: CASP3
data source: Spike
xref: 7774019

FOS
type: Protein
entity reference: FOS

BCL2_inactive
type: Protein
entity reference: BCL2

9525868
type: PublicationXref
id: 9525868
db: PubMed
title: A single BIR domain of XIAP sufficient for inhibiting caspases

.EYA1.PROMOTES.FGF3.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.EYA1.FGF3
data source: Spike
controller: EYA1
xref: 12874121

9463381
type: PublicationXref
id: 9463381
db: PubMed
title: The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4

SIX1
type: Protein
entity reference: SIX1

CASP7_inactive
type: Protein
entity reference: CASP7

http://www.ncbi.nlm.nih.gov/#4915
type: UnificationXref
id: 4915
db: Entrez Gene

.SIX1.PROMOTES.FGF3.
type: Catalysis
controlled: Other.P.SIX1.FGF3
control type: ACTIVATION
controller: SIX1
data source: Spike
xref: 12874121

TAU:F.000011
type: UnificationXref
id: TAU:F-000011
db: Spike DB

ESR1_DNA
type: DnaRegion
entity reference: ESR1

GATA3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2625

CASP8
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#841

TAU:F.000018
type: UnificationXref
id: TAU:F-000018
db: Spike DB

VDR
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7421

MIR433
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#574034

.Complex.CK2....UNKNOWN.NFE2L2.
type: TemplateReactionRegulation
control type: ACTIVATION_UNKMECH
controlled: Transcription.Regulation.U.CK2.NFE2L2
data source: Spike
controller: Caseine Kinase 2
xref: 17512459

http://www.ncbi.nlm.nih.gov/#5599
type: UnificationXref
id: 5599
db: Entrez Gene

15725726
type: PublicationXref
id: 15725726
db: PubMed
title: Overview of cell death signaling pathways

PAX2_RNA
type: RnaRegion
entity reference: PAX2

14963018
type: PublicationXref
id: 14963018
db: PubMed
title: Evidence of STAT1 phosphorylation modulated by MAPKs, MEK1 and MSK1

FOS_RNA
type: RnaRegion
entity reference: FOS

ATF2_inactive
type: Protein
entity reference: ATF2

Translation
type: MolecularInteraction
participant: GDF15
participant: GDF15_RNA

11154691
type: PublicationXref
id: 11154691
db: PubMed
title: Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation

Translation
type: MolecularInteraction
participant: BMP4_inactive
participant: BMP4_RNA

FGF10_inactive
type: Protein
entity reference: FGF10

12396231
type: PublicationXref
id: 12396231
db: PubMed
title: Protein kinase CK2: structure, regulation and role in cellular decisions of life and death

1828073
type: PublicationXref
id: 1828073
db: PubMed
title: Phosphorylation of neuromodulin (GAP-43) by casein kinase II. Identification of phosphorylation sites and regulation by calmodulin

http://www.ncbi.nlm.nih.gov/#6495
type: UnificationXref
id: 6495
db: Entrez Gene

17276395
type: PublicationXref
id: 17276395
db: PubMed
title: A p53-type response element in the GDF15 promoter confers high specificity for p53 activation

http://www.ncbi.nlm.nih.gov/#6774
type: UnificationXref
id: 6774
db: Entrez Gene

BMP4_inactive
type: Protein
entity reference: BMP4

http://www.ncbi.nlm.nih.gov/#6772
type: UnificationXref
id: 6772
db: Entrez Gene

EGR1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1958

XIAP
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#331

PhysicalInteraction [Complex CK2 {} -- CTNNB1 ]
type: MolecularInteraction
participant: Caseine Kinase 2
participant: CTNNB1
comment: Inter- and Supramolecular Interactions of Protein Kinase CK2 and their Relevance for Genome Integrity
xref: 15951851

ATM
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#472

http://www.ncbi.nlm.nih.gov/#331
type: UnificationXref
id: 331
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#841
type: UnificationXref
id: 841
db: Entrez Gene

.EGR1.PROMOTES.EGFR.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.EGR1.EGFR
data source: Spike
controller: EGR1
xref: 11830539

http://www.ncbi.nlm.nih.gov/#842
type: UnificationXref
id: 842
db: Entrez Gene

.SIX1.PROMOTES.FGF10.
type: Catalysis
controlled: Dephosphorylation.P.SIX1.FGF10
control type: ACTIVATION
controller: SIX1
data source: Spike
xref: 12874121

.Family.Rho.GTPases..RAC1..PROMOTES.Family.PAK....
type: Catalysis
controlled: Physical.Interaction.P.Rho.GTPases.PAK
control type: ACTIVATION
controller: Rho GTPases.family
data source: Spike
xref: 9705280

http://www.ncbi.nlm.nih.gov/#6778
type: UnificationXref
id: 6778
db: Entrez Gene

ARG1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#383

http://www.ncbi.nlm.nih.gov/#637
type: UnificationXref
id: 637
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#840
type: UnificationXref
id: 840
db: Entrez Gene

SP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6667

http://www.ncbi.nlm.nih.gov/#839
type: UnificationXref
id: 839
db: Entrez Gene

.STAT3.PROMOTES.EGR1.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.STAT3.EGR1
data source: Spike
controller: STAT3
xref: 17129668

GAP43_inactive
type: Protein
entity reference: GAP43

http://www.ncbi.nlm.nih.gov/#5076
type: UnificationXref
id: 5076
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#5077
type: UnificationXref
id: 5077
db: Entrez Gene

SIX1_inactive
type: Protein
entity reference: SIX1

FGF2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2247

http://www.ncbi.nlm.nih.gov/#836
type: UnificationXref
id: 836
db: Entrez Gene

ESR1_inactive
type: Protein
entity reference: ESR1

PAX8_inactive
type: Protein
entity reference: PAX8

.STAT3.PROMOTES.BCL2.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.STAT3.BCL2
data source: Spike
controller: STAT3
xref: 11994401

NOTCH1
type: Protein
entity reference: NOTCH1

CASP9
type: Protein
entity reference: CASP9

NTRK2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4915

Translation
type: MolecularInteraction
participant: IGF2_RNA
participant: IGF2

.CASP9.PROMOTES.CASP3.
type: Catalysis
controlled: Proteolytic.Processing.P.CASP9.CASP3
control type: ACTIVATION
controller: CASP9
data source: Spike
xref: 9390557

FGFR1
type: Protein
entity reference: FGFR1

http://www.ncbi.nlm.nih.gov/#5080
type: UnificationXref
id: 5080
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#1602
type: UnificationXref
id: 1602
db: Entrez Gene

HES1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3280

http://www.ncbi.nlm.nih.gov/#7421
type: UnificationXref
id: 7421
db: Entrez Gene

.Family.ERK....PROMOTES.EGR1.
type: Catalysis
controlled: N/A.P.ERK.EGR1
control type: ACTIVATION
controller: ERK.family
data source: Spike
xref: 11165042

http://www.ncbi.nlm.nih.gov/#6662
type: UnificationXref
id: 6662
db: Entrez Gene

18431400
type: PublicationXref
id: 18431400
db: PubMed
title: Transcriptional control of human p53-regulated genes

CDKN1A_RNA
type: RnaRegion
entity reference: CDKN1A

10801845
type: PublicationXref
id: 10801845
db: PubMed
title: Cell cycle-regulated phosphorylation of the human SIX1 homeodomain protein

CREBBP
type: Protein
entity reference: CREBBP

JAG1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#182

PARP1_inactive
type: Protein
entity reference: PARP1

.NOTCH1.PROMOTES.JAG1.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NOTCH1.JAG1
data source: Spike
controller: NOTCH1
xref: 18495817

HMX3
type: Protein
entity reference: HMX3

18252210
type: PublicationXref
id: 18252210
db: PubMed
title: Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein

http://www.ncbi.nlm.nih.gov/#6667
type: UnificationXref
id: 6667
db: Entrez Gene

19749794
type: PublicationXref
id: 19749794
db: PubMed
title: Pro-proliferative FoxM1 is a target of p53-mediated repression

9323209
type: PublicationXref
id: 9323209
db: PubMed
title: Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis

CDKN1B_inactive
type: Protein
entity reference: CDKN1B

http://www.ncbi.nlm.nih.gov/#5970
type: UnificationXref
id: 5970
db: Entrez Gene

TP53
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7157

BCL2_DNA
type: DnaRegion
entity reference: BCL2

15649893
type: PublicationXref
id: 15649893
db: PubMed
title: Casein kinase 2- and protein kinase A-regulated adenomatous polyposis coli and beta-catenin cellular localization is dependent on p38 MAPK

http://www.ebi.ac.uk/chebi/#17489
type: UnificationXref
id: 17489
db: ChEBI

FGFR2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2263

.WNT1.PROMOTES.PAX2.
type: Catalysis
controlled: Other.P.WNT1.PAX2
control type: ACTIVATION
controller: WNT1
data source: Spike
xref: 18495817

.cAMP.PROMOTES.Complex.PKA.(PRKA)...(PRKACA).
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.cAMP.PKA.(PRKA)
data source: Spike
controller: cAMP
xref: 12937157

14693367
type: PublicationXref
id: 14693367
db: PubMed
title: Ets ternary complex transcription factors

ERK.family
type: Protein
data source: Spike
xref: TAU:F.000011

Translation
type: MolecularInteraction
participant: ESR1_inactive
participant: ESR1_RNA

ESR1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2099

Caseine Kinase 2
type: Complex
data source: Spike
display name: CK2.complex

http://www.ncbi.nlm.nih.gov/#5015
type: UnificationXref
id: 5015
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#5154
type: UnificationXref
id: 5154
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#5013
type: UnificationXref
id: 5013
db: Entrez Gene

FGFR1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2260

12881425
type: PublicationXref
id: 12881425
db: PubMed
title: Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation

http://www.ncbi.nlm.nih.gov/#596
type: UnificationXref
id: 596
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#598
type: UnificationXref
id: 598
db: Entrez Gene

.Complex.CK2....INHIBITS.SIX1.
type: Catalysis
controlled: Phosphorylation.I.CK2.SIX1
control type: INHIBITION
controller: Caseine Kinase 2
data source: Spike
xref: 10801845

FGF3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2248

Spike
type: Provenance

10617656
type: PublicationXref
id: 10617656
db: PubMed
title: Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation

http://www.ncbi.nlm.nih.gov/#2260
type: UnificationXref
id: 2260
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#324
type: UnificationXref
id: 324
db: Entrez Gene

18521080
type: PublicationXref
id: 18521080
db: PubMed
title: MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma

http://www.ncbi.nlm.nih.gov/#2261
type: UnificationXref
id: 2261
db: Entrez Gene

platelet-derived growth factor receptor
type: Complex
data source: Spike
display name: PDGFR.complex

http://www.ncbi.nlm.nih.gov/#2263
type: UnificationXref
id: 2263
db: Entrez Gene

GAP43
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2596

FGF3_inactive
type: Protein
entity reference: FGF3

Src kinases.family
type: Protein
data source: Spike
xref: CEN:F.329887

.EGR1.PROMOTES.CDKN1A.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.EGR1.CDKN1A
data source: Spike
controller: EGR1
xref: 12690110

http://www.ncbi.nlm.nih.gov/#574034
type: UnificationXref
id: 574034
db: Entrez Gene

mir-221.family
type: Protein
data source: Spike
xref: TAU:F.329923

PKA (PRKA).complex_DNA
type: DnaRegion

OTX2_RNA
type: RnaRegion
entity reference: OTX2

.STAT1.PROMOTES.CDKN1B.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.STAT1.CDKN1B
data source: Spike
controller: STAT1
xref: 17992189

WNT1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7471

.MAPK8.INHIBITS.BCL2.
type: Catalysis
controlled: Other.I.MAPK8.BCL2
control type: INHIBITION
controller: MAPK8
data source: Spike
xref: 18471544

Translation
type: MolecularInteraction
participant: DACH2_RNA
participant: DACH2

http://www.ncbi.nlm.nih.gov/#4760
type: UnificationXref
id: 4760
db: Entrez Gene

NEUROD1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4760

WNT1
type: Protein
entity reference: WNT1

.TP53.PROMOTES.APC.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.TP53.APC
data source: Spike
controller: TP53
xref: 18431400

BMP4_RNA
type: RnaRegion
entity reference: BMP4

PAX8
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7849

http://www.ncbi.nlm.nih.gov/#4094
type: UnificationXref
id: 4094
db: Entrez Gene

PAX2_DNA
type: DnaRegion
entity reference: PAX2

9930654
type: PublicationXref
id: 9930654
db: PubMed
title: Caspase-3-induced gelsolin fragmentation contributes to actin cytoskeletal collapse, nucleolysis, and apoptosis of vascular smooth muscle cells exposed to proinflammatory cytokines

FGF20_inactive
type: Protein
entity reference: FGF20

http://www.ncbi.nlm.nih.gov/#2299
type: UnificationXref
id: 2299
db: Entrez Gene

14695375
type: PublicationXref
id: 14695375
db: PubMed
title: Six1 controls patterning of the mouse otic vesicle

.TP53.PROMOTES.CDKN1A.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.TP53.CDKN1A
data source: Spike
controller: TP53
xref: 12748190
xref: 21163364
xref: 19749794

.MPG.INHIBITS.ESR1.
type: TemplateReactionRegulation
control type: INHIBITION
controlled: Transcription.Regulation.I.MPG.ESR1
data source: Spike
controller: MPG
xref: 17129768

http://www.ncbi.nlm.nih.gov/#572
type: UnificationXref
id: 572
db: Entrez Gene

IGF2
type: Protein
entity reference: IGF2

http://www.ncbi.nlm.nih.gov/#472
type: UnificationXref
id: 472
db: Entrez Gene

EGR1
type: Protein
entity reference: EGR1

MAF
type: Protein
entity reference: MAF

FGF3_RNA
type: RnaRegion
entity reference: FGF3

8358790
type: PublicationXref
id: 8358790
db: PubMed
title: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

.NOTCH1.PROMOTES.BMP4.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NOTCH1.BMP4
data source: Spike
controller: NOTCH1
xref: 17537801

.WNT1.PROMOTES.JAG1.
type: Catalysis
controlled: Other.P.WNT1.JAG1
control type: ACTIVATION
controller: WNT1
data source: Spike
xref: 18495817

.CREBBP.PROMOTES.NFE2L2.
type: Catalysis
controlled: Physical.Interaction.P.CREBBP.NFE2L2
control type: ACTIVATION
controller: CREBBP
data source: Spike
xref: 11154691

SP1_inactive
type: Protein
entity reference: SP1

.MAPK8.INHIBITS.BCL2L1.
type: Catalysis
controlled: mRNA.stability.I.MAPK8.BCL2L1
control type: INHIBITION
controller: MAPK8
data source: Spike
xref: 18471544

DACH2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#117154

http://www.ncbi.nlm.nih.gov/#5879
type: UnificationXref
id: 5879
db: Entrez Gene

DACH2
type: Protein
entity reference: DACH2

APC
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#324

.SIX1.INHIBITS.EYA1.
type: TemplateReactionRegulation
control type: INHIBITION
controlled: Transcription.Regulation.I.SIX1.EYA1
data source: Spike
controller: SIX1
xref: 17035528

APC_inactive
type: Protein
entity reference: APC

http://www.ncbi.nlm.nih.gov/#581
type: UnificationXref
id: 581
db: Entrez Gene

DLX5
type: Protein
entity reference: DLX5

GBX2_inactive
type: Protein
entity reference: GBX2

PDGFR.complex_inactive
type: Protein

MPG
type: Protein
entity reference: MPG

http://www.ncbi.nlm.nih.gov/#4780
type: UnificationXref
id: 4780
db: Entrez Gene

RELA
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5970

.MAPK8.PROMOTES.JUN.
type: Catalysis
controlled: Phosphorylation.P.MAPK8.JUN
control type: ACTIVATION
controller: MAPK8
data source: Spike
xref: 9169478
xref: 10617656
xref: 12871843
xref: 9561845
xref: 1460037
xref: 10871633

.Family.IAP.fam....INHIBITS.CASP3.
type: Catalysis
controlled: Physical.Interaction.I.IAP.fam.CASP3
control type: INHIBITION
controller: IAP-fam.family
data source: Spike
xref: 9990849

http://www.ncbi.nlm.nih.gov/#383
type: UnificationXref
id: 383
db: Entrez Gene

FGF2
type: Protein
entity reference: FGF2

9230442
type: PublicationXref
id: 9230442
db: PubMed
title: X-linked IAP is a direct inhibitor of cell-death proteases

.Family.FGF..FGF3,.FGF2,.FGF1,.FGF20,.FGF10..PROMOTES.Family.FGFR..FGFR1,.FGFR2,.FGFR3..
type: Catalysis
controlled: Physical.Interaction.P.FGF.FGFR
control type: ACTIVATION
controller: FGF.family
data source: Spike
xref: 15613447

.VDR.PROMOTES.CASP3.
type: Catalysis
controlled: Other.P.VDR.CASP3
control type: ACTIVATION
controller: VDR
data source: Spike
xref: 18259074

.JAG1.PROMOTES.CDKN1B.
type: Catalysis
controlled: Other.P.JAG1.CDKN1B
control type: ACTIVATION
controller: JAG1
data source: Spike
xref: 16495313

JAG1_inactive
type: Protein
entity reference: JAG1

10871633
type: PublicationXref
id: 10871633
db: PubMed
title: c-Jun inhibits transforming growth factor beta-mediated transcription by repressing Smad3 transcriptional activity

BMP4
type: Protein
entity reference: BMP4

PDGFA_DNA
type: DnaRegion
entity reference: PDGFA

http://www.ncbi.nlm.nih.gov/#2246
type: UnificationXref
id: 2246
db: Entrez Gene

DACH1_RNA
type: RnaRegion
entity reference: DACH1

http://www.ncbi.nlm.nih.gov/#2247
type: UnificationXref
id: 2247
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#182
type: UnificationXref
id: 182
db: Entrez Gene

GDF15_DNA
type: DnaRegion
entity reference: GDF15

http://www.ncbi.nlm.nih.gov/#2248
type: UnificationXref
id: 2248
db: Entrez Gene

TGFB1_DNA
type: DnaRegion
entity reference: TGFB1

CREBBP
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1387

9990849
type: PublicationXref
id: 9990849
db: PubMed
title: IAP family proteins--suppressors of apoptosis

18413744
type: PublicationXref
id: 18413744
db: PubMed
title: MicroRNAs 221 and 222 bypass quiescence and compromise cell survival

11165042
type: PublicationXref
id: 11165042
db: PubMed
title: Activation of mitogen-activated protein kinase phosphatase 2 by gonadotropin-releasing hormone

CDKN1A_DNA
type: DnaRegion
entity reference: CDKN1A

CASP6_inactive
type: Protein
entity reference: CASP6

WNT1_inactive
type: Protein
entity reference: WNT1

BID
type: Protein
entity reference: BID

http://www.ncbi.nlm.nih.gov/#2353
type: UnificationXref
id: 2353
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#2255
type: UnificationXref
id: 2255
db: Entrez Gene

TP53
type: Protein
entity reference: TP53

ID3
type: Protein
entity reference: ID3

JUN
type: Protein
entity reference: JUN

CDKN1C_inactive
type: Protein
entity reference: CDKN1C

9065401
type: PublicationXref
id: 9065401
db: PubMed
title: Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

DACH1_DNA
type: DnaRegion
entity reference: DACH1

FGF10
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2255

cAMP
type: SmallMoleculeReference
xref: http://www.ebi.ac.uk/chebi/#17489

http://www.ncbi.nlm.nih.gov/#117154
type: UnificationXref
id: 117154
db: Entrez Gene

.FOXI1.PROMOTES.SIX1.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.FOXI1.SIX1
data source: Spike
controller: FOXI1
xref: 17035528

Translation
type: MolecularInteraction
participant: EYA1_RNA
participant: EYA1

9765224
type: PublicationXref
id: 9765224
db: PubMed
title: Pro-caspase-3 is a major physiologic target of caspase-8

.STAT6.PROMOTES.GATA3.
type: Catalysis
controlled: Translational.Regulation.P.STAT6.GATA3
control type: ACTIVATION
controller: STAT6
data source: Spike
xref: 17312100

.SP1.PROMOTES.GDF15.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.SP1.GDF15
data source: Spike
controller: SP1
xref: 11895857

Translation
type: MolecularInteraction
participant: SIX1_inactive
participant: SIX1_RNA

NFE2L2
type: Protein
entity reference: NFE2L2

9111042
type: PublicationXref
id: 9111042
db: PubMed
title: A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members

.PAX6.PROMOTES.MAF.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.PAX6.MAF
data source: Spike
controller: PAX6
xref: 12128206

XIAP_inactive
type: Protein
entity reference: XIAP

CASP7
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#840

.Complex.PKA.(PRKA)....PROMOTES.RELA.
type: Catalysis
controlled: Phosphorylation.P.PKA.(PRKA).RELA
control type: ACTIVATION
controller: Protein kinase, cAMP-dependent
data source: Spike
xref: 9660950

.Complex.CK2....UNKNOWN.GAP43.
type: Catalysis
controlled: Phosphorylation.U.CK2.GAP43
control type: ACTIVATION_UNKMECH
controller: Caseine Kinase 2
data source: Spike
xref: 1828073

NEUROD1
type: Protein
entity reference: NEUROD1

NTRK2
type: Protein
entity reference: NTRK2

FGF20
type: Protein
entity reference: FGF20

12384981
type: PublicationXref
id: 12384981
db: PubMed
title: Regulation of life and death by the zinc finger transcription factor Egr-1

SOX9_inactive
type: Protein
entity reference: SOX9

.TP53.INHIBITS.Complex.CK2...(CSNK2B).
type: Catalysis
controlled: Physical.Interaction.I.TP53.CK2
control type: INHIBITION
controller: TP53
data source: Spike
xref: 11180407

OTX1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5013

VDR
type: Protein
entity reference: VDR

FGF1
type: Protein
entity reference: FGF1

NOTCH1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4851

11483855
type: PublicationXref
id: 11483855
db: PubMed
title: Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis

http://www.ncbi.nlm.nih.gov/#340784
type: UnificationXref
id: 340784
db: Entrez Gene

16713569
type: PublicationXref
id: 16713569
db: PubMed
title: A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration

GBX2
type: Protein
entity reference: GBX2

.WNT1.PROMOTES.NOTCH1.
type: Catalysis
controlled: Other.P.WNT1.NOTCH1
control type: ACTIVATION
controller: WNT1
data source: Spike
xref: 18495817

.EGR1.PROMOTES.TGFB1.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.EGR1.TGFB1
data source: Spike
controller: EGR1
xref: 12384981

OTX1_RNA
type: RnaRegion
entity reference: OTX1

12748190
type: PublicationXref
id: 12748190
db: PubMed
title: p21/CDKN1A mediates negative regulation of transcription by p53

http://www.ncbi.nlm.nih.gov/#142
type: UnificationXref
id: 142
db: Entrez Gene

9390557
type: PublicationXref
id: 9390557
db: PubMed
title: Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

.Family.mir.221....INHIBITS.ESR1.
type: Catalysis
controlled: N/A.I.mir.221.ESR1
control type: INHIBITION
controller: mir-221.family
data source: Spike
xref: 18790736

MAPK8
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5599

1460037
type: PublicationXref
id: 1460037
db: PubMed
title: Interleukin 2-induced activation of Ras requires two domains of interleukin 2 receptor beta subunit, the essential region for growth stimulation and Lck-binding domain

.Complex.PKA.(PRKA)....INHIBITS.APC.
type: Catalysis
controlled: Phosphorylation.I.PKA.(PRKA).APC
control type: INHIBITION
controller: Protein kinase, cAMP-dependent
data source: Spike
xref: 15649893

11021801
type: PublicationXref
id: 11021801
db: PubMed
title: Regulation of STAT3 by direct binding to the Rac1 GTPase

GAP43
type: Protein
entity reference: GAP43

18471544
type: PublicationXref
id: 18471544
db: PubMed
title: Cellular and molecular mechanisms of liver injury

ARG1
type: Protein
entity reference: ARG1

.MAPK8.PROMOTES.STAT1.
type: Catalysis
controlled: Phosphorylation.P.MAPK8.STAT1
control type: ACTIVATION
controller: MAPK8
data source: Spike
xref: 14963018

12871843
type: PublicationXref
id: 12871843
db: PubMed
title: Role of c-jun N-terminal kinase in the induced release of GM-CSF, RANTES and IL-8 from human airway smooth muscle cells

EYA1_RNA
type: RnaRegion
entity reference: EYA1

http://www.ncbi.nlm.nih.gov/#2596
type: UnificationXref
id: 2596
db: Entrez Gene

TNF
type: Protein
entity reference: TNF

cAMP
type: SmallMolecule
entity reference: cAMP

7834748
type: PublicationXref
id: 7834748
db: PubMed
title: Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

Translation
type: MolecularInteraction
participant: CDKN1A_inactive
participant: CDKN1A_RNA

ID3_DNA
type: DnaRegion
entity reference: ID3

.SP1.PROMOTES.CDKN1A.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.SP1.CDKN1A
data source: Spike
controller: SP1
xref: 17026958

9660950
type: PublicationXref
id: 9660950
db: PubMed
title: Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300

.XIAP.INHIBITS.CASP3.
type: Catalysis
controlled: Ubiquitination.I.XIAP.CASP3
control type: INHIBITION
controller: XIAP
data source: Spike
xref: 9230442
xref: 9525868
xref: 11447297
xref: 11927604

12874121
type: PublicationXref
id: 12874121
db: PubMed
title: The role of Six1 in mammalian auditory system development

HES1
type: Protein
entity reference: HES1

.Complex.TCF....PROMOTES.EGR1.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.TCF.EGR1
data source: Spike
controller: Ternary Complex Factor
xref: 14693367

JUN
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3725

PKA (PRKA).complex_RNA
type: RnaRegion

17026958
type: PublicationXref
id: 17026958
db: PubMed
title: p38MAPK mediates benzyl isothiocyanate-induced p21WAF1 expression in vascular smooth muscle cells via the regulation of Sp1

SP1
type: Protein
entity reference: SP1

17899380
type: PublicationXref
id: 17899380
db: PubMed
title: Delineation of the caspase-9 signaling cascade

http://www.ncbi.nlm.nih.gov/#4350
type: UnificationXref
id: 4350
db: Entrez Gene

BAX
type: Protein
entity reference: BAX

MPG
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4350

TAU:F.000008
type: UnificationXref
id: TAU:F-000008
db: Spike DB

Translation
type: MolecularInteraction
participant: NTRK2
participant: NTRK2_RNA

BID_inactive
type: Protein
entity reference: BID

.SIX1.PROMOTES.LFNG.
type: Catalysis
controlled: Translational.Regulation.P.SIX1.LFNG
control type: ACTIVATION
controller: SIX1
data source: Spike
xref: 14695375

PAK.family_inactive
type: Protein

PAX3
type: Protein
entity reference: PAX3

CDKN1B
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1027

MAF.family
type: Protein
data source: Spike
member physical entity: MAF
xref: CEN:F.329894

http://www.ncbi.nlm.nih.gov/#3481
type: UnificationXref
id: 3481
db: Entrez Gene

TNF
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7124

11447297
type: PublicationXref
id: 11447297
db: PubMed
title: Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death

19073166
type: PublicationXref
id: 19073166
db: PubMed
title: miR-17 family miRNAs are expressed during early mammalian development and regulate stem cell differentiation

CTNNB1_inactive
type: Protein
entity reference: CTNNB1

.CASP8.PROMOTES.CASP3.
type: Catalysis
controlled: Proteolytic.Processing.P.CASP8.CASP3
control type: ACTIVATION
controller: CASP8
data source: Spike
xref: 9765224
xref: 11437602

11830539
type: PublicationXref
id: 11830539
db: PubMed
title: Early Growth Response-1 gene mediates up-regulation of epidermal growth factor receptor expression during hypoxia.

CDKN1A
type: Protein
entity reference: CDKN1A

CASP3
type: Protein
entity reference: CASP3

NFE2L2_RNA
type: RnaRegion
entity reference: NFE2L2

GATA3
type: Protein
entity reference: GATA3

.SIX1.PROMOTES.BMP4.
type: Catalysis
controlled: N/A.P.SIX1.BMP4
control type: ACTIVATION
controller: SIX1
data source: Spike
xref: 12874121

.TNF.PROMOTES.TNFRSF1B.
type: Catalysis
controlled: Physical.Interaction.P.TNF.TNFRSF1B
control type: ACTIVATION
controller: TNF
data source: Spike
xref: 15450251

http://www.ncbi.nlm.nih.gov/#8717
type: UnificationXref
id: 8717
db: Entrez Gene

FGFR.family_inactive
type: Protein

.Complex.CK2....PROMOTES.APC.
type: Catalysis
controlled: Phosphorylation.P.CK2.APC
control type: ACTIVATION
controller: Caseine Kinase 2
data source: Spike
xref: 15649893

CK2.complex_inactive
type: Protein

GATA3_inactive
type: Protein
entity reference: GATA3

.Family.JNK....PROMOTES.JUN.
type: Catalysis
controlled: Phosphorylation.P.JNK.JUN
control type: ACTIVATION
controller: JNK.family
data source: Spike
xref: 11369511

Translation
type: MolecularInteraction
participant: MAF_RNA
participant: MAF

FOS_DNA
type: DnaRegion
entity reference: FOS

.WNT1.PROMOTES.PAX8.
type: Catalysis
controlled: Other.P.WNT1.PAX8
control type: ACTIVATION
controller: WNT1
data source: Spike
xref: 18495817

NFE2L2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4780

Translation
type: MolecularInteraction
participant: EGR1_RNA
participant: EGR1_inactive

Translation
type: MolecularInteraction
participant: PAX2_RNA
participant: PAX2_inactive

PDGFA_RNA
type: RnaRegion
entity reference: PDGFA

.Family.Src.kinases....UNKNOWN.CTNNB1.
type: TemplateReactionRegulation
control type: ACTIVATION_UNKMECH
controlled: Transcription.Regulation.U.Src.kinases.CTNNB1
data source: Spike
controller: Src kinases.family
xref: 18815812

.MIR433.INHIBITS.FGF20.
type: Catalysis
controlled: N/A.I.MIR433.FGF20
control type: INHIBITION
controller: MIR433
data source: Spike
xref: 18252210

FGF20
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#26281

EGR1_inactive
type: Protein
entity reference: EGR1

IGF2_DNA
type: DnaRegion
entity reference: IGF2

Translation
type: MolecularInteraction
participant: CDKN1B_RNA
participant: CDKN1B_inactive

STAT3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6774

.CASP3.INHIBITS.CTNNB1.
type: Catalysis
controlled: Proteolytic.Processing.I.CASP3.CTNNB1
control type: INHIBITION
controller: CASP3
data source: Spike
xref: 9348292

.CASP3.PROMOTES.CASP9.
type: Catalysis
controlled: Proteolytic.Processing.P.CASP3.CASP9
control type: ACTIVATION
controller: CASP3
data source: Spike
xref: 8900201

RAC1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5879

http://www.ncbi.nlm.nih.gov/#7124
type: UnificationXref
id: 7124
db: Entrez Gene

CTNNB1_DNA
type: DnaRegion
entity reference: CTNNB1

SOX9
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6662

9606
type: UnificationXref
id: 9606
db: taxonomy

GDF15
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9518

IGF2_RNA
type: RnaRegion
entity reference: IGF2

Translation
type: MolecularInteraction
participant: PDGFA
participant: PDGFA_RNA

PAX2_inactive
type: Protein
entity reference: PAX2

FGF3
type: Protein
entity reference: FGF3

RELA
type: Protein
entity reference: RELA

FGF3_DNA
type: DnaRegion
entity reference: FGF3

CDKN1A_inactive
type: Protein
entity reference: CDKN1A

FGF.family
type: Protein
data source: Spike
member physical entity: FGF2
member physical entity: FGF20
member physical entity: FGF10
member physical entity: FGF3
member physical entity: FGF1
xref: ELK:F.329919

LEG/TCF-BETA CATENIN
type: Complex
data source: Spike
display name: LEF/TCF-BETA CATENIN.complex

Translation
type: MolecularInteraction
participant: APC_RNA
participant: APC_inactive

.NEUROD1.PROMOTES.NTRK2.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NEUROD1.NTRK2
data source: Spike
controller: NEUROD1
xref: 16251211

ESR1_RNA
type: RnaRegion
entity reference: ESR1

9705280
type: PublicationXref
id: 9705280
db: PubMed
title: Structural requirements for PAK activation by Rac GTPases

http://www.ncbi.nlm.nih.gov/#3955
type: UnificationXref
id: 3955
db: Entrez Gene

.CASP3.PROMOTES.CASP7.
type: Catalysis
controlled: Proteolytic.Processing.P.CASP3.CASP7
control type: ACTIVATION
controller: CASP3
data source: Spike
xref: 17899380

12165491
type: PublicationXref
id: 12165491
db: PubMed
title: Thymocyte development in early growth response gene 1-deficient mice

FOXI1
type: Protein
entity reference: FOXI1

http://www.ncbi.nlm.nih.gov/#1026
type: UnificationXref
id: 1026
db: Entrez Gene

STAT6
type: Protein
entity reference: STAT6

http://www.ncbi.nlm.nih.gov/#1027
type: UnificationXref
id: 1027
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#1028
type: UnificationXref
id: 1028
db: Entrez Gene

PAX2
type: Protein
entity reference: PAX2

.Family.PDGF..PDGFA..PROMOTES.Complex.PDGFR...(PDGFRA).
type: Catalysis
controlled: Physical.Interaction.P.PDGF.PDGFR
control type: ACTIVATION
controller: PDGF.family
data source: Spike
xref: 19931527
xref: 21357737

15003631
type: PublicationXref
id: 15003631
db: PubMed
title: GATA3 and NeuroD distinguish auditory and vestibular neurons during development of the mammalian inner ear

SOX9
type: Protein
entity reference: SOX9

TRADD
type: Protein
entity reference: TRADD

FOS
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2353

15613447
type: PublicationXref
id: 15613447
db: PubMed
title: The role of fibroblast growth factors and their receptors in prostate cancer

11583631
type: PublicationXref
id: 11583631
db: PubMed
title: BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

HMX3_inactive
type: Protein
entity reference: HMX3

CTNNB1_RNA
type: RnaRegion
entity reference: CTNNB1

21163364
type: PublicationXref
id: 21163364
db: PubMed
title: Dose-dependent mutual regulation between Wip1 and p53 following UVC irradiation

EYA1_DNA
type: DnaRegion
entity reference: EYA1

18815812
type: PublicationXref
id: 18815812
db: PubMed
title: Src family kinases as mediators of endothelial permeability: effects on inflammation and metastasis

ID3_RNA
type: RnaRegion
entity reference: ID3

http://www.ncbi.nlm.nih.gov/#11140
type: UnificationXref
id: 11140
db: Entrez Gene

CASP3_inactive
type: Protein
entity reference: CASP3

LFNG_inactive
type: Protein
entity reference: LFNG

JNK.family
type: Protein
data source: Spike
xref: TAU:F.000008

.RAC1.PROMOTES.STAT3.
type: Catalysis
controlled: Physical.Interaction.P.RAC1.STAT3
control type: ACTIVATION
controller: RAC1
data source: Spike
xref: 11021801

BCL2L1_DNA
type: DnaRegion
entity reference: BCL2L1

.WNT1.PROMOTES.GBX2.
type: Catalysis
controlled: Other.P.WNT1.GBX2
control type: ACTIVATION
controller: WNT1
data source: Spike
xref: 18495817

ELK:F.329919
type: UnificationXref
id: ELK:F-329919
db: Spike DB

ELK:F.329918
type: UnificationXref
id: ELK:F-329918
db: Spike DB

.CASP3.PROMOTES.CASP6.
type: Catalysis
controlled: Proteolytic.Processing.P.CASP3.CASP6
control type: ACTIVATION
controller: CASP3
data source: Spike
xref: 17899380

EGR1_DNA
type: DnaRegion
entity reference: EGR1

EGFR_RNA
type: RnaRegion
entity reference: EGFR

PhysicalInteraction [GATA3 -- NEUROD1 ]
type: MolecularInteraction
participant: NEUROD1
participant: GATA3
xref: 15003631

Translation
type: MolecularInteraction
participant: DACH1_RNA
participant: DACH1

Translation
type: MolecularInteraction
participant: NOTCH1_RNA
participant: NOTCH1_inactive

7774019
type: PublicationXref
id: 7774019
db: PubMed
title: Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

ATF2
type: Protein
entity reference: ATF2

PhysicalInteraction [CDC37 -- Complex CK2 {} ]
type: MolecularInteraction
participant: Caseine Kinase 2
participant: CDC37
xref: 12396231

17129768
type: PublicationXref
id: 17129768
db: PubMed
title: Crosstalk of DNA glycosylases with pathways other than base excision repair

17129668
type: PublicationXref
id: 17129668
db: PubMed
title: STAT3 as a central mediator of neoplastic cellular transformation

17035528
type: PublicationXref
id: 17035528
db: PubMed
title: The transcription factor six1 inhibits neuronal and promotes hair cell fate in the developing zebrafish (Danio rerio) inner ear

GSN
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2934

http://www.ncbi.nlm.nih.gov/#7133
type: UnificationXref
id: 7133
db: Entrez Gene

DLX5_inactive
type: Protein
entity reference: DLX5

BAD
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#572

NTRK2_DNA
type: DnaRegion
entity reference: NTRK2

17512459
type: PublicationXref
id: 17512459
db: PubMed
title: Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2

ELK:F.329923
type: UnificationXref
id: ELK:F-329923
db: Spike DB

ELK:F.329924
type: UnificationXref
id: ELK:F-329924
db: Spike DB

.Complex.TCF....PROMOTES.FOS.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.TCF.FOS
data source: Spike
controller: Ternary Complex Factor
xref: 14693367

18495817
type: PublicationXref
id: 18495817
db: PubMed
title: Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode

STAT1
type: Protein
entity reference: STAT1

ELK:F.329920
type: UnificationXref
id: ELK:F-329920
db: Spike DB

PhysicalInteraction [CREBBP -- RELA ]
type: MolecularInteraction
participant: RELA
participant: CREBBP
xref: 16713569
xref: 18241676
xref: 12881425

.JAG1.PROMOTES.NOTCH1.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.JAG1.NOTCH1
data source: Spike
controller: JAG1
xref: 18495817

.TP53.INHIBITS.APC.
type: TemplateReactionRegulation
control type: INHIBITION
controlled: Transcription.Regulation.I.TP53.APC
data source: Spike
controller: TP53
xref: 18431400

CEN:F.329894
type: UnificationXref
id: CEN:F-329894
db: Spike DB

9561845
type: PublicationXref
id: 9561845
db: PubMed
title: Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development

http://www.ncbi.nlm.nih.gov/#3399
type: UnificationXref
id: 3399
db: Entrez Gene

.Family.JNK....PROMOTES.EGR1.
type: Catalysis
controlled: N/A.P.JNK.EGR1
control type: ACTIVATION
controller: JNK.family
data source: Spike
xref: 11165042

ARG1_inactive
type: Protein
entity reference: ARG1

17992189
type: PublicationXref
id: 17992189
db: PubMed
title: Identification of a novel p53-dependent activation pathway of STAT1 by antitumour genotoxic agents

FGF10
type: Protein
entity reference: FGF10

STAT1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6772

MAPK8
type: Protein
entity reference: MAPK8

NFE2L2_DNA
type: DnaRegion
entity reference: NFE2L2

18212054
type: PublicationXref
id: 18212054
db: PubMed
title: MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression

TAU:F.329923
type: UnificationXref
id: TAU:F-329923
db: Spike DB

OTX1_DNA
type: DnaRegion
entity reference: OTX1

MIR433
type: Protein
entity reference: MIR433

18241676
type: PublicationXref
id: 18241676
db: PubMed
title: NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

PAX2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5076

IAP-fam.family
type: Protein
data source: Spike
xref: TAU:F.000018

12937157
type: PublicationXref
id: 12937157
db: PubMed
title: Ethanol stimulates ciliary beating by dual cyclic nucleotide kinase activation in bovine bronchial epithelial cells

Translation
type: MolecularInteraction
participant: BCL2_inactive
participant: BCL2_RNA

JAG1_RNA
type: RnaRegion
entity reference: JAG1

.EGR1.PROMOTES.IGF2.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.EGR1.IGF2
data source: Spike
controller: EGR1
xref: 12384981

BCL2
type: Protein
entity reference: BCL2

Translation
type: MolecularInteraction
participant: TGFB1_RNA
participant: TGFB1

CEN:F.329887
type: UnificationXref
id: CEN:F-329887
db: Spike DB

NFE2L2_inactive
type: Protein
entity reference: NFE2L2

DACH1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1602

TRADD
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8717

HMX3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#340784

.Family.mir.221....INHIBITS.CDKN1B.
type: Catalysis
controlled: N/A.I.mir.221.CDKN1B
control type: INHIBITION
controller: mir-221.family
data source: Spike
xref: 18521080
xref: 18413744

RELA_inactive
type: Protein
entity reference: RELA

EYA1
type: Protein
entity reference: EYA1

SIX1_RNA
type: RnaRegion
entity reference: SIX1

TAU:F.329914
type: UnificationXref
id: TAU:F-329914
db: Spike DB

EGR1_RNA
type: RnaRegion
entity reference: EGR1

BAX_inactive
type: Protein
entity reference: BAX

CASP9
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#842

APC
type: Protein
entity reference: APC

Translation
type: MolecularInteraction
participant: OTX2_RNA
participant: OTX2

RAC1
type: Protein
entity reference: RAC1

GDF15
type: Protein
entity reference: GDF15

Translation
type: MolecularInteraction
participant: ID3_RNA
participant: ID3

http://www.ncbi.nlm.nih.gov/#2138
type: UnificationXref
id: 2138
db: Entrez Gene

PARP1
type: Protein
entity reference: PARP1

18328430
type: PublicationXref
id: 18328430
db: PubMed
title: E2F1-Regulated MicroRNAs Impair TGFbeta-Dependent Cell-Cycle Arrest and Apoptosis in Gastric Cancer

ID3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3399

FGFR.family
type: Protein
data source: Spike
member physical entity: FGFR3
member physical entity: FGFR2
member physical entity: FGFR1
xref: ELK:F.329920

PDGFA
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5154

.cAMP.PROMOTES.ATF2.
type: Catalysis
controlled: N/A.P.cAMP.ATF2
control type: ACTIVATION
controller: cAMP
data source: Spike
xref: 17185372

Rho GTPases.family
type: Protein
data source: Spike
member physical entity: RAC1
xref: ELK:F.329924

CDC37
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#11140

.Family.mir.221....INHIBITS.CDKN1C.
type: Catalysis
controlled: N/A.I.mir.221.CDKN1C
control type: INHIBITION
controller: mir-221.family
data source: Spike
xref: 18521080
xref: 18413744

mir-17.family
type: Protein
data source: Spike
xref: TAU:F.329914

CDKN1B_DNA
type: DnaRegion
entity reference: CDKN1B

http://www.ncbi.nlm.nih.gov/#1958
type: UnificationXref
id: 1958
db: Entrez Gene

BCL2L1_inactive
type: Protein
entity reference: BCL2L1

http://www.ncbi.nlm.nih.gov/#1956
type: UnificationXref
id: 1956
db: Entrez Gene

9169478
type: PublicationXref
id: 9169478
db: PubMed
title: T cell proliferation in response to interleukins 2 and 7 requires p38MAP kinase activation

JAG1_DNA
type: DnaRegion
entity reference: JAG1

15450251
type: PublicationXref
id: 15450251
db: PubMed
title: Ligands working as receptors: reverse signaling by members of the TNF superfamily enhance the plasticity of the immune system

.WNT1.PROMOTES.DLX5.
type: Catalysis
controlled: Other.P.WNT1.DLX5
control type: ACTIVATION
controller: WNT1
data source: Spike
xref: 18495817

Protein kinase, cAMP-dependent
type: Complex
data source: Spike
display name: PKA (PRKA).complex

GDF15_RNA
type: RnaRegion
entity reference: GDF15

MAF
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4094

GBX2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2637

NOTCH1_inactive
type: Protein
entity reference: NOTCH1

12690110
type: PublicationXref
id: 12690110
db: PubMed
title: p21Cip1 gene expression is modulated by Egr1: a novel regulatory mechanism involved in the resveratrol antiproliferative effect

http://www.ncbi.nlm.nih.gov/#3280
type: UnificationXref
id: 3280
db: Entrez Gene

JAG1
type: Protein
entity reference: JAG1

.ATM.PROMOTES.SP1.
type: Catalysis
controlled: Phosphorylation.P.ATM.SP1
control type: ACTIVATION
controller: ATM
data source: Spike
xref: 18619531
xref: 18171990

TAU:F.329931
type: UnificationXref
id: TAU:F-329931
db: Spike DB

11180407
type: PublicationXref
id: 11180407
db: PubMed
title: Wild-type p53 inhibits protein kinase CK2 activity

12128206
type: PublicationXref
id: 12128206
db: PubMed
title: L-Maf, a downstream target of Pax6, is essential for chick lens development.

18790736
type: PublicationXref
id: 18790736
db: PubMed
title: MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer

TNFRSF1B_inactive
type: Protein
entity reference: TNFRSF1B

18171990
type: PublicationXref
id: 18171990
db: PubMed
title: Phosphorylation of Sp1 in response to DNA damage by ataxia telangiectasia-mutated kinase

TP53_RNA
type: RnaRegion
entity reference: TP53

XIAP
type: Protein
entity reference: XIAP

21357737
type: PublicationXref
id: 21357737
db: PubMed
title: Pathological signaling via PDGFR{alpha} involves chronic activation of Akt and suppression of p53

11927604
type: PublicationXref
id: 11927604
db: PubMed
title: The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites

17537801
type: PublicationXref
id: 17537801
db: PubMed
title: Notch signalling is needed to maintain, but not to initiate, the formation of prosensory patches in the chick inner ear

11895857
type: PublicationXref
id: 11895857
db: PubMed
title: Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53

CASP3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#836

.MAPK8.PROMOTES.BAX.
type: Catalysis
controlled: Phosphorylation.P.MAPK8.BAX
control type: ACTIVATION
controller: MAPK8
data source: Spike
xref: 18471544

.SIX1.PROMOTES.DACH1.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.SIX1.DACH1
data source: Spike
controller: SIX1
xref: 17035528