The multiple personalities of the regulatory subunit of protein kinase CK2: CK2 dependent and CK2 independent roles reveal a secret identity for CK2beta
PhysicalInteraction [Complex CK2 {} -- FGF1 ]
PhysicalInteraction [Complex CK2 {} -- FGF2 ]
The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32
Homeotic factor ATBF1 induces the cell cycle arrest associated with neuronal differentiation
Progressive hearing loss in mice with a mutated vitamin D receptor gene
Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear
Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells
The JAK-STAT signaling pathway: input and output integration
[W206R]-procaspase 3: an inactivatable substrate for caspase 8
Involvement of JNK regulation in oxidative stress-mediated murine liver injury by microcystin-LR
Gonadotropin-releasing hormone couples to 3',5'-cyclic adenosine-5'-monophosphate pathway through novel protein kinase Cdelta and -epsilon in LbetaT2 gonadotrope cells
Identification of phosphorylation sites on transcription factor Sp1 in response to DNA damage and its accumulation at damaged sites
Recent developments in our understanding of how platelet-derived growth factor (PDGF) and its receptors contribute to proliferative vitreoretinopathy
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
Dismantling cell-cell contacts during apoptosis is coupled to a caspase-dependent proteolytic cleavage of beta-catenin
A single BIR domain of XIAP sufficient for inhibiting caspases
The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4
Overview of cell death signaling pathways
Evidence of STAT1 phosphorylation modulated by MAPKs, MEK1 and MSK1
Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation
Protein kinase CK2: structure, regulation and role in cellular decisions of life and death
Phosphorylation of neuromodulin (GAP-43) by casein kinase II. Identification of phosphorylation sites and regulation by calmodulin
A p53-type response element in the GDF15 promoter confers high specificity for p53 activation
PhysicalInteraction [Complex CK2 {} -- CTNNB1 ]
Inter- and Supramolecular Interactions of Protein Kinase CK2 and their Relevance for Genome Integrity
Transcriptional control of human p53-regulated genes
Cell cycle-regulated phosphorylation of the human SIX1 homeodomain protein
Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein
Pro-proliferative FoxM1 is a target of p53-mediated repression
Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis
Casein kinase 2- and protein kinase A-regulated adenomatous polyposis coli and beta-catenin cellular localization is dependent on p38 MAPK
Ets ternary complex transcription factors
Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation
Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation
MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma
Caspase-3-induced gelsolin fragmentation contributes to actin cytoskeletal collapse, nucleolysis, and apoptosis of vascular smooth muscle cells exposed to proinflammatory cytokines
Six1 controls patterning of the mouse otic vesicle
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
X-linked IAP is a direct inhibitor of cell-death proteases
c-Jun inhibits transforming growth factor beta-mediated transcription by repressing Smad3 transcriptional activity
IAP family proteins--suppressors of apoptosis
MicroRNAs 221 and 222 bypass quiescence and compromise cell survival
Activation of mitogen-activated protein kinase phosphatase 2 by gonadotropin-releasing hormone
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
Pro-caspase-3 is a major physiologic target of caspase-8
A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members
Regulation of life and death by the zinc finger transcription factor Egr-1
Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
p21/CDKN1A mediates negative regulation of transcription by p53
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
Interleukin 2-induced activation of Ras requires two domains of interleukin 2 receptor beta subunit, the essential region for growth stimulation and Lck-binding domain
Regulation of STAT3 by direct binding to the Rac1 GTPase
Cellular and molecular mechanisms of liver injury
Role of c-jun N-terminal kinase in the induced release of GM-CSF, RANTES and IL-8 from human airway smooth muscle cells
Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death
Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300
The role of Six1 in mammalian auditory system development
p38MAPK mediates benzyl isothiocyanate-induced p21WAF1 expression in vascular smooth muscle cells via the regulation of Sp1
Delineation of the caspase-9 signaling cascade
Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death
miR-17 family miRNAs are expressed during early mammalian development and regulate stem cell differentiation
Early Growth Response-1 gene mediates up-regulation of epidermal growth factor receptor expression during hypoxia.
Structural requirements for PAK activation by Rac GTPases
Thymocyte development in early growth response gene 1-deficient mice
GATA3 and NeuroD distinguish auditory and vestibular neurons during development of the mammalian inner ear
The role of fibroblast growth factors and their receptors in prostate cancer
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis
Dose-dependent mutual regulation between Wip1 and p53 following UVC irradiation
Src family kinases as mediators of endothelial permeability: effects on inflammation and metastasis
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
PhysicalInteraction [CDC37 -- Complex CK2 {} ]
Crosstalk of DNA glycosylases with pathways other than base excision repair
STAT3 as a central mediator of neoplastic cellular transformation
The transcription factor six1 inhibits neuronal and promotes hair cell fate in the developing zebrafish (Danio rerio) inner ear
Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2
Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode
Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development
Identification of a novel p53-dependent activation pathway of STAT1 by antitumour genotoxic agents
MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression
NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK
Ethanol stimulates ciliary beating by dual cyclic nucleotide kinase activation in bovine bronchial epithelial cells
E2F1-Regulated MicroRNAs Impair TGFbeta-Dependent Cell-Cycle Arrest and Apoptosis in Gastric Cancer
T cell proliferation in response to interleukins 2 and 7 requires p38MAP kinase activation
Ligands working as receptors: reverse signaling by members of the TNF superfamily enhance the plasticity of the immune system
p21Cip1 gene expression is modulated by Egr1: a novel regulatory mechanism involved in the resveratrol antiproliferative effect
Wild-type p53 inhibits protein kinase CK2 activity
L-Maf, a downstream target of Pax6, is essential for chick lens development.
MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer
Phosphorylation of Sp1 in response to DNA damage by ataxia telangiectasia-mutated kinase
Pathological signaling via PDGFR{alpha} involves chronic activation of Akt and suppression of p53
The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites
Notch signalling is needed to maintain, but not to initiate, the formation of prosensory patches in the chick inner ear
Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53