ACTIVATION
ACTIVATION
MAP2K7
NFKBIA
DAXX
PubMed
12215209
Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice
ACTIVATION
MKK1/2.family_inactive
PubMed
8702708
Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins
PubMed
10593883
MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway
MADD
Entrez Gene
1386
ChEBI
16618
INHIBITION
PubMed
1381507
Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product
ELK4
PubMed
20932475
A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-B activation
Entrez Gene
6416
MAP2K5
MYC
IL1R1
Entrez Gene
23118
Entrez Gene
1978
JUN_inactive
TSC1-TSC2.complex_inactive
PubMed
21135870
Structural studies of NF-B signaling
AKT1
MAP2K2
ACTIVATION
PubMed
15654083
Identification of dynamic proteome changes upon ligand activation of Trk-receptors using two-dimensional fluorescence difference gel electrophoresis and mass spectrometry
Entrez Gene
10454
TRAF2_inactive
GTP-Ras.complex
INHIBITION
TAB1
MAP3K5
PubMed
10892748
A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction
PubMed
16081065
Dual-specificity phosphatase DUSP1 protects overactivation of hypoxia-inducible factor 1 through inactivating ERK MAPK
PubMed
19442713
Dexamethasone protects auditory hair cells against TNFalpha-initiated apoptosis via activation of PI3K/Akt and NFkappaB signaling
GSK3B
TrkA/B.family
IL1A
PubMed
14988025
Constitutively active Src facilitates NGF-induced phosphorylation of TrkA and causes enhancement of the MAPK signaling in SK-N-MC cells
STAT3
CHUK
MAP2K1
MKK3/6.family_inactive
EGFR
PDGF.family
PubMed
11726515
Tyrosine phosphorylation of Grb2 by Bcr/Abl and epidermal growth factor receptor: a novel regulatory mechanism for tyrosine kinase signaling
PubMed
16540633
The phosphoinositide 3-kinase/Akt1/Par-4 axis: a cancer-selective therapeutic target
INHIBITION
PubMed
10473620
Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus
ACTIVATION
NR4A1
ACTIVATION
ACTIVATION
ACTIVATION
Akt.family_inactive
FAS_inactive
Entrez Gene
7157
Entrez Gene
3725
ACTIVATION
Entrez Gene
3727
ACTIVATION
EGFR_inactive
ACTIVATION
PubMed
12172553
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
EGFR
PubMed
15746962
The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling
ACTIVATION
DUSP1
PubMed
20093361
Expression of a homeostatic regulator, Wip1 (wild-type p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation
PubMed
9743501
Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx
PIP3_inactive
PIP3
CDC42
ACTIVATION
Entrez Gene
4216
Entrez Gene
4217
MAP3K5
JUN.family
Entrez Gene
4214
PubMed
19931527
Recent developments in our understanding of how platelet-derived growth factor (PDGF) and its receptors contribute to proliferative vitreoretinopathy
Entrez Gene
4215
PubMed
11369511
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
PAK.family
IKBKB
MAP2K1_inactive
INHIBITION
PubMed
10523862
Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)
ACTIVATION
Entrez Gene
10746
Entrez Gene
8567
ATF2
Entrez Gene
7186
EGF
TP53_inactive
PubMed
18429814
ERK5 is involved in TCR-induced apoptosis through the modification of Nur77
MAP3K2
Entrez Gene
7189
GRB2
GSK3B
ACTIVATION
MTOR
Homo sapiens
MAP3K7_inactive
Entrez Gene
2885
MAP2K1
MAP2K4_inactive
PI(4,5)P2
Entrez Gene
6895
MADD_inactive
Entrez Gene
355
MAP3K7
Entrez Gene
356
Spike DB
TAU:F-000011
MAP3K4
Spike DB
TAU:F-000010
PubMed
16317285
Molecular targeting of growth factor receptor-bound 2 (Grb2) as an anti-cancer strategy
Spike DB
TAU:F-000013
JNK.family_inactive
EIF4EBP1
ACTIVATION
Entrez Gene
207
PubMed
16251197
TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd
Entrez Gene
5599
Entrez Gene
5598
MAP2K6_inactive
Entrez Gene
6885
ACTIVATION
ACTIVATION
ACTIVATION
IKBKB
ACTIVATION
Spike DB
TAU:F-000020
Entrez Gene
5594
Spike DB
TAU:F-000023
ATF2_inactive
PubMed
7758105
The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation
Spike DB
TAU:F-000021
FAS
MAPK7
ACTIVATION
FASLG
ACTIVATION
Entrez Gene
6774
PubMed
15968404
Thrombin activates the p21-activated kinase in pulmonary artery smooth muscle cells. Role in tissue factor expression
ACTIVATION
Entrez Gene
5170
INHIBITION
Entrez Gene
3554
Entrez Gene
3552
Entrez Gene
4609
Entrez Gene
3551
CHUK_inactive
Entrez Gene
1616
PDPK1
IL1A
HIF1A_inactive
SOS1
INHIBITION
ELK4
Tuberous sclerosis complex
TSC1-TSC2.complex
RAC2
PubMed
8248196
Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation
HIF1A
PubMed
11274386
Akt phosphorylates and regulates the orphan nuclear receptor Nur77
ELK4_inactive
INHIBITION
SOS1_inactive
ACTIVATION
DUSP1
PubMed
7716521
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2.
GDP-Ras.complex_inactive
TP53
MLKs.family
ACTIVATION
TARBP2
ACTIVATION
MAP3K1
PubMed
14693367
Ets ternary complex transcription factors
ERK.family
TRADD_inactive
Entrez Gene
6654
ACTIVATION
MAP2K6
ACTIVATION
INHIBITION
ACTIVATION
PubMed
1851250
Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils
MAP2K2
Spike
platelet-derived growth factor receptor
PDGFR.complex
MAP2K3
Entrez Gene
998
PubMed
12876277
PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation
TAB2
p38.family_inactive
ACTIVATION
INHIBITION
MAPK7
JUND
PubMed
15866172
Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases
TARBP2
NFKBIA_inactive
ACTIVATION
TRAF2
Entrez Gene
5881
Entrez Gene
5880
PubMed
10688666
Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin
INHIBITION
PDPK1
PubMed
14579250
TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology
IRAKs.family_inactive
RAC3
MAP3K3
Entrez Gene
4792
PubMed
20458382
Structure of the EGF receptor transactivation circuit integrates multiple signals with cell context
PubMed
14734742
Regulation of c-Jun N-terminal kinase by MEKK-2 and mitogen-activated protein kinase kinase kinases in rheumatoid arthritis
Entrez Gene
1649
RHOA
ACTIVATION
Entrez Gene
5879
AKT1
PubMed
9228058
Characterization of Fas (Apo-1, CD95)-Fas ligand interaction
Entrez Gene
5728
PDGFR.complex_inactive
NR4A1
MYC
PubMed
11394873
Adaptor protein Lad relays PDGF signal to Grb2 in lung cells: a tissue-specific PDGF signal transduction
ACTIVATION
MAPK1
TGFbR.family_inactive
ACTIVATION
PubMed
11483955
TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation
Entrez Gene
387
AP-1 Subtype II: cJun:ATF2
AP-1_II.complex
ACTIVATION
ACTIVATION
PIP3
MAP3K3
GDP-Ras.complex
CHUK
PubMed
17053865
A PI3K pathway mediates hair cell survival and opposes gentamicin toxicity in neonatal rat organ of Corti
ACTIVATION
TP53
JUN
MAPK7_inactive
MAP2K5_DNA
TAB1
Entrez Gene
5606
MKK4/7.family_inactive
INHIBITION
Entrez Gene
5607
MAP3K7
Entrez Gene
5608
MAP2K5_inactive
Entrez Gene
5609
Nuclear factor kappa-B
NFkB.complex
MAP2K4
Class I phosphoinositide-3-kinase
PI3K.complex
CDC42
PubMed
11073940
MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway
MADD
RAF.family
RAF.family_inactive
TrkA/B.family_inactive
PubMed
19718661
Effect on the Ras/Raf signaling pathway of post-translational modifications of neurofibromin: in silico study of protein modification responsible for regulatory pathways
IRAKs.family
RAC2
PubMed
12242663
MEKK1-induced apoptosis requires TRAIL death receptor activation and is inhibited by AKT/PKB through inhibition of MEKK1 cleavage
PubMed
8131746
Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues
TARBP2_inactive
ACTIVATION
ACTIVATION
TRAF6
PubMed
19479203
The role of IL-1 in the pathogenesis of heart disease
MAP3K5_inactive
ACTIVATION
PPM1D
RHOA
PubMed
11416147
The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis
ACTIVATION
ACTIVATION
ACTIVATION
PubMed
1849075
Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase)
PubMed
10634209
TNF-induced signaling in apoptosis
Entrez Gene
3091
MAPK8
PubMed
9244310
Identification and characterization of an IkappaB kinase
ACTIVATION
PubMed
16289117
Structural basis for the interaction of TAK1 kinase with its activating protein TAB1
MKK4/7.family
PubMed
12628002
An analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5) by mitogen-activated protein kinase kinase 5 (MKK5) in vitro
TNF
JUN
MAPK1
GRB2
ACTIVATION
Entrez Gene
5604
Entrez Gene
5605
ACTIVATION
ACTIVATION
Spike DB
TAU:F-000008
Spike DB
TAU:F-000009
PDPK1_inactive
PAK.family_inactive
TGF-beta.family
INHIBITION
IL1R1_inactive
TNFRSF1A_inactive
PubMed
16339969
Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms
MAP2K3
TNF
PubMed
16288292
Perturbations of the AKT signaling pathway in human cancer
ACTIVATION
ACTIVATION
MYC_inactive
Entrez Gene
8717
FGFR.family_inactive
Entrez Gene
2475
NR4A1_inactive
MAP2K7
ACTIVATION
MKK1/2.family
DDIT3_inactive
ACTIVATION
ACTIVATION
PI(4,5)P2
ACTIVATION
ACTIVATION
PubMed
10085062
Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta
PubMed
19804757
Phosphorylation of the human microRNA-generating complex mediates MAPK/Erk signaling
PubMed
14764989
The functional interactions between the p53 and MAPK signaling pathways
PubMed
12447987
Role of ERK and calcium in the hypoxia-induced activation of HIF-1
STAT3
TRAF6
PPM1D
RAC1
Entrez Gene
7124
TGFbR.family
taxonomy
9606
PubMed
15378007
Stat3 upregulates MEK5 expression in human breast cancer cells
Entrez Gene
1843
DAXX_inactive
p38.family
JUND
ACTIVATION
INHIBITION
ACTIVATION
PubMed
8565075
TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
Translation
RAC3
ACTIVATION
FGF.family
PubMed
2158863
Molecular cloning and expression of a receptor for human tumor necrosis factor
PubMed
9705280
Structural requirements for PAK activation by Rac GTPases
Entrez Gene
3164
MTOR
TRADD
TRAF2
Akt.family
PubMed
15613447
The role of fibroblast growth factors and their receptors in prostate cancer
MAP3K1_inactive
HIF1A
ACTIVATION
MAP2K4
PTEN
JNK.family
ACTIVATION
Spike DB
ELK:F-329919
Spike DB
ELK:F-329918
ACTIVATION
ACTIVATION
Spike DB
ELK:F-329917
Spike DB
ELK:F-329916
TRAF6_inactive
Spike DB
ELK:F-329915
Spike DB
ELK:F-329912
Spike DB
ELK:F-329911
Spike DB
ELK:F-329910
NFkB.complex_inactive
ATF2
NFKBIA
GRB2_inactive
ACTIVATION
ACTIVATION
Entrez Gene
7132
EIF4EBP1
TAB2
ACTIVATION
PubMed
11971971
Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence
PubMed
18463697
Sensing and integration of Erk and PI3K signals by Myc
EGF
Spike DB
ELK:F-329923
Spike DB
ELK:F-329922
Spike DB
ELK:F-329924
PubMed
1322500
Raf-1 activates MAP kinase-kinase
Spike DB
ELK:F-329921
Spike DB
ELK:F-329920
MAP2K7_inactive
ELK1
ACTIVATION
PubMed
11283254
Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress
DAXX
SOS1
PTEN
PubMed
15778394
Regulation of p38 MAPK by MAPK kinases 3 and 6 in fibroblast-like synoviocytes
TNFRSF1A
ACTIVATION_UNKMECH
MAPK8
ACTIVATION
PubMed
9639556
Differential activation of stress-activated protein kinase kinases SKK4/MKK7 and SKK1/MKK4 by the mixed-lineage kinase-2 and mitogen-activated protein kinase kinase (MKK) kinase-1
MAP3K1
PubMed
9126929
Identification of amino acid residues important for ligand binding to Fas
Entrez Gene
2932
MKK3/6.family
ACTIVATION
TNFRSF1A
Entrez Gene
2002
PubMed
2549071
Transient increase in phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol trisphosphate during activation of human neutrophils
NGFs.family
TRADD
Entrez Gene
2005
Entrez Gene
8493
MAP2K5
INHIBITION
JIP.family
PubMed
9020136
Activation of the Sap-1a transcription factor by the c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase
RAC1
ChEBI
18348
MAP3K2
ACTIVATION
ACTIVATION
PubMed
12584189
Glycogen synthase kinase 3 beta is a natural activator of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 1 (MEKK1)
MAP2K5_RNA
PubMed
12947395
MAPK pathways in radiation responses
PubMed
12356755
nhibition of p38 MAPK by glucocorticoids via induction of MAPK phosphatase-1 enhances nontypeable Haemophilus influenzae-induced expression of toll-like receptor 2.
FGFR.family
ACTIVATION
Rho GTPases.family
ACTIVATION
EIF4EBP1_inactive
PubMed
17724081
Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1
TAB2_inactive
ERK.family_inactive
PubMed
9346485
IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK
MTOR_inactive
ACTIVATION
GTP-Ras.complex_inactive
Entrez Gene
1956
MAP3K4
PubMed
16123588
Crosstalk between Pten and Ras signaling pathways in tumor development
Entrez Gene
1950
Entrez Gene
1147
PubMed
11883936
Nuclear receptor and apoptosis initiator NGFI-B is a substrate for kinase ERK2
ACTIVATION
ELK1
PubMed
20704570
Regulation of TGF-beta signalling by protein phosphatases
FAS
IL1R1
MAP2K6
PI3K.complex_inactive
DDIT3
FASLG
DDIT3
PubMed
10781582
ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation
PubMed
21357737
Pathological signaling via PDGFR{alpha} involves chronic activation of Akt and suppression of p53
ELK1_inactive