A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain
A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction
Dexamethasone protects auditory hair cells against TNFalpha-initiated apoptosis via activation of PI3K/Akt and NFkappaB signaling
TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex
NF-kappaB Signaling in the Aging Process
Endothelial activation by angiotensin II through NFkappaB and p38 pathways: Involvement of NFkappaB-inducible kinase (NIK), free oxygen radicals, and selective inhibition by aspirin
MKP-1 represses JNK-mediated apoptosis via NF-kappa B regulation
Constitutive silencing of IFN-beta promoter is mediated by NRF (NF-kappaB-repressing factor), a nuclear inhibitor of NF-kappaB
Involvement of two NF-kappa B binding elements in tumor necrosis factor alpha -, CD40-, and epstein-barr virus latent membrane protein 1-mediated induction of the cIAP2
Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner
Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation
MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
IRF3 mediates a TLR3/TLR4-specific antiviral gene program
The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation
Overview of cell death signaling pathways
C/EBP, NF-kappa B, and c-Ets family members and transcriptional regulation of the cell-specific and inducible macrophage inflammatory protein 1 alpha immediate-early gene
Regulation of lipocalin-type prostaglandin D synthase gene expression by Hes-1 through E-box and interleukin-1 beta via two NF-kappa B elements in rat leptomeningeal cells
Suppression of PTEN expression by NF-kappa B prevents apoptosis
Glucocorticoid-mediated gene suppression of rat cytokine-induced neutrophil chemoattractant CINC/gro, a member of the interleukin-8 family, through impairment of NF-kappa B activation
Regulation of interleukin 12 p40 expression through an NF-kappa B half-site
Role of CXCL1 in tumorigenesis of melanoma
The NF-kappaB binding site is essential for transcriptional activation of the IL-15 gene
Structural and functional characterization of the promoter regions of the NFKB2 gene
NFkappaB activation is required for interferon regulatory factor-1-mediated interferon beta induction
Direct binding of Fas-associated death domain (FADD) to the tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 is regulated by the death effector domain of FADD
Nuclear factor kappa B activates proenkephalin transcription in T lymphocytes
Dysregulated activation of activator protein 1 in keratinocytes of atopic dermatitis patients with enhanced expression of granulocyte/macrophage-colony stimulating factor
Characterization of Fas (Apo-1, CD95)-Fas ligand interaction
X-linked IAP is a direct inhibitor of cell-death proteases
The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation
NF-kappa B regulates IL-1 beta transcription through a consensus NF-kappa B binding site and a nonconsensus CRE-like site
IAP family proteins--suppressors of apoptosis
TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa)B mediated induction of MT1-MMP
Nonionic detergents induce dimerization among members of the Bcl-2 family
microRNA 21: response to hormonal therapies and regulatory function in leiomyoma, transformed leiomyoma and leiomyosarcoma cells
NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
Global mapping of c-Myc binding sites and target gene networks in human B cells
IKBKE is over-expressed in glioma and contributes to resistance of glioma cells to apoptosis via activating NF-B
Regulation of monocyte chemoattractant protein-1 by the oxidized lipid, 13-hydroperoxyoctadecadienoic acid, in vascular smooth muscle cells via nuclear factor-kappa B (NF-kappa B)
Transcriptional activation of the human TNF-alpha promoter by superantigen in human monocytic cells: role of NF-kappa B
Transcriptional and post-transcriptional mechanisms involved in the differential expression of LPS-induced IL-1 and TNF mRNA
PIDD mediates NF-kappaB activation in response to DNA damage
The characterization of the promoter of the gene encoding the p50 subunit of NF-kappa B indicates that it participates in its own regulation
CD95 (Fas)-induced caspase-mediated proteolysis of NF-kappaB
The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
NF-kappa B and STAT5 play important roles in the regulation of mouse Toll-like receptor 2 gene expression
Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death
Expression, biological activities and mechanisms of action of A20 (TNFAIP3)
TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis
Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family
An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation
Adenovirus vector-induced expression of the C-X-C chemokine IP-10 is mediated through capsid-dependent activation of NF-kappaB
Thrombin receptor mediated signals induce expressions of interleukin 6 and granulocyte colony stimulating factor via NF-kappa B activation in synovial fibroblasts
Coordination of cell signaling, chromatin remodeling, histone modifications, and regulator recruitment in human matrix metalloproteinase 9 gene transcription
Proinflammatory cytokines induce NF-kappaB-dependent/NO-independent chemokine gene expression in MIN6 beta cells
TNF-alpha and H2O2 induce IL-18 and IL-18R beta expression in cardiomyocytes via NF-kappa B activation
Nitric oxide-induced resistance or sensitization to death in tumor cells
An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway
Cytokine-mediated transcriptional induction of the human inducible nitric oxide synthase gene requires both activator protein 1 and nuclear factor kappaB-binding sites
The role of Bcl-2 family member BNIP3 in cell death and disease: NIPping at the heels of cell death
Differential roles for NF-kappa B in endotoxin and oxygen induction of interleukin-8 in the macrophage
Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons
Tumor necrosis factor alpha transcription in macrophages is attenuated by an autocrine factor that preferentially induces NF-kappaB p50
STAT3 as a central mediator of neoplastic cellular transformation
Three NF-kappa B sites in the I kappa B-alpha promoter are required for induction of gene expression by TNF alpha
Tumour necrosis factor-alpha and interferon-gamma synergistically activate the RANTES promoter through nuclear factor kappaB and interferon regulatory factor 1 (IRF-1) transcription factors
Protein kinase CK2 phosphorylates and upregulates Akt/PKB
The organization of the human GSTP1-1 gene promoter and its response to retinoic acid and cellular redox status
Identification of amino acid residues important for ligand binding to Fas
Cytokine regulation of interleukin-6 gene expression in astrocytes involves activation of an NF-kappa B-like nuclear protein
IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases
Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway
The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites
TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB
Importance of PIKKs in NF-B activation by genotoxic stress
Regulation of IL-18 production by IFN gamma and PGE2 in mouse microglial cells: involvement of NF-kB pathway in the regulatory processes
Expression of membrane type 1 matrix metalloproteinase (MT1-MMP) in A2058 melanoma cells is associated with MMP-2 activation and increased tumor growth and vascularization
In vitro selection and characterization of Bcl-X(L)-binding proteins from a mix of tissue-specific mRNA display libraries
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins
A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-B activation
IL-1beta-dependent activation of NF-kappaB mediates PGE2 release via the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase
DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1
Regulation of MHC class I and beta 2-microglobulin gene expression in human neuronal cells. Factor binding to conserved cis-acting regulatory sequences correlates with expression of the genes
IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program
Nuclear protein IkappaB-zeta inhibits the activity of STAT3
STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer
IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kappa B and activator protein-2
Regulation of the gene encoding the monocyte chemoattractant protein 1 (MCP-1) in the mouse and rat brain in response to circulating LPS and proinflammatory cytokines
[W206R]-procaspase 3: an inactivatable substrate for caspase 8
Requirements for NF-kappaB activation in hemorrhagic shock
Latent membrane protein 1 of Epstein-Barr virus induces CD83 by the NF-kappaB signaling pathway
Induction of the gene encoding mucosal vascular addressin cell adhesion molecule 1 by tumor necrosis factor alpha is mediated by NF-kappa B proteins
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
Differential regulation of Bax and Bak by anti-apoptotic Bcl-2 family proteins Bcl-B and Mcl-1
Reciprocal cross talk between gonadotropin-releasing hormone (GnRH) and prostaglandin receptors regulates GnRH receptor expression and differential gonadotropin secretion
ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3alpha gene expression in Caco-2 human colonic epithelial cells
A single BIR domain of XIAP sufficient for inhibiting caspases
Regulation of IKKbeta by miR-199a affects NF-kappaB activity in ovarian cancer cells
Innate immunity meets with cellular stress at the IKK complex: regulation of the IKK complex by HSP70 and HSP90
The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation
IntAct--open source resource for molecular interaction data
Transcriptional suppression of mir-29b-1/mir-29a promoter by c-Myc, hedgehog, and NF-kappaB
NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites
Induction of RANTES chemokine expression in human astrocytic cells is dependent upon activation of NF-kappaB transcription factor
Interleukin-10 gene expression in adult T-cell leukemia
Enhancers and transcription factors controlling the inducibility of the tumor necrosis factor-alpha promoter in primary macrophages
MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation
APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis
Regulation of the gadd45beta promoter by NF-kappaB
Protein-protein interactions involving IKKgamma (NEMO) that promote the activation of NF-kappaB
A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells
Activation of interleukin-6 gene expression through the NF-kappa B transcription factor
The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis
Up-regulation of MMP-2 and MMP-9 leads to degradation of type IV collagen during skeletal muscle reperfusion injury; protection by the MMP inhibitor, doxycycline
Downstream activation of a TATA-less promoter by Oct-2, Bob1, and NF-kappaB directs expression of the homing receptor BLR1 to mature B cells
PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1
Induction of microRNA-155 during Helicobacter pylori infection and its negative regulatory role in the inflammatory response
Involvement of NF-kappaB in the regulation of cyclooxygenase-2 protein expression in LPS-stimulated J774 macrophages
Suppression of lipopolysaccharide-induced nuclear factor-kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages
Interaction of aging-associated signaling cascades: inhibition of NF-kappaB signaling by longevity factors FoxOs and SIRT1
Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli
IAP proteins: blocking the road to death's door
- and tumor necrosis factor alpha-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone. Functional analysis of the human icam1
Pro-caspase-3 is a major physiologic target of caspase-8
Bradykinin induces interleukin-6 expression in astrocytes through activation of nuclear factor-kappaB
A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members
DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1
Regulation of life and death by the zinc finger transcription factor Egr-1
Regulation of human IP-10 gene expression in astrocytoma cells by inflammatory cytokines
TNF-alpha induces two distinct caspase-8 activation pathways
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas
Mutagenesis of the BH3 domain of BAX identifies residues critical for dimerization and killing
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
Activation of death-inducing signaling complex (DISC) by pro-apoptotic C-terminal fragment of RIP
Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock
Following a TRAIL: update on a ligand and its five receptors
IL-1beta induction of RANTES (regulated upon activation, normal T cell expressed and secreted) chemokine gene expression in endometriotic stromal cells depends on a nuclear factor-kappaB site in the proximal promoter
Regulation of JAK-STAT signalling in the immune system
IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain
Apaf-1 is a transcriptional target for E2F and p53
c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment
Molecular regulation of monocyte chemoattractant protein-1 expression in pancreatic beta-cells
IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival
TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
Identification of two NF-kappa B sites in mouse CD95 ligand (Fas ligand) promoter: functional analysis in T cell hybridoma
Molecular cloning and expression of a receptor for human tumor necrosis factor
TNF initiates E-selectin transcription in human endothelial cells through parallel TRAF-NF-kappa B and TRAF-RAC/CDC42-JNK-c-Jun/ATF2 pathways
Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex
Regulation of Fas-Ligand Expression during Activation-induced Cell Death in T Lymphocytes via Nuclear Factor B
Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
TNF combined with IFN-alpha accelerates NF-kappaB-mediated apoptosis through enhancement of Fas expression in colon cancer cells
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
Role of interferon regulatory factor-1 and mitogen-activated protein kinase pathways in the induction of nitric oxide synthase-2 in retinal pigmented epithelial cells
Membrane type 1-matrix metalloproteinase is regulated by chemokines monocyte-chemoattractant protein-1/ccl2 and interleukin-8/CXCL8 in endothelial cells during angiogenesis
Ceramide-induced and age-associated increase in macrophage COX-2 expression is mediated through up-regulation of NF-kappa B activity
Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop
NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling
The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination
Rel induces interferon regulatory factor 4 (IRF-4) expression in lymphocytes: modulation of interferon-regulated gene expression by rel/nuclear factor kappaB