IFNB1_DNA
type: DnaRegion
entity reference: IFNB1

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.NFKB2.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.NFKB2
xref: 7541912
data source: Spike
controller: NFkB.complex

.ATM.PROMOTES.IKBKG.
type: Catalysis
controlled: Phosphorylation.P.ATM.IKBKG
control type: ACTIVATION
data source: Spike
controller: ATM
xref: 16497931

Translation
type: MolecularInteraction
participant: IL10
participant: IL10_RNA

http://www.ncbi.nlm.nih.gov/#7097
type: UnificationXref
db: Entrez Gene
id: 7097

Translation
type: MolecularInteraction
participant: CCL5
participant: CCL5_RNA

Translation
type: MolecularInteraction
participant: TRAF2_inactive
participant: TRAF2_RNA

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.CFLAR.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.CFLAR
xref: 11359904
data source: Spike
controller: NFkB.complex

MMP9_DNA
type: DnaRegion
entity reference: MMP9

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.NFKB1.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.NFKB1
xref: 1740105
data source: Spike
controller: NFkB.complex

HSP90-CDC37.complex
type: Complex
data source: Spike
name: HSP90-CDC37 chaperone complex

.BNIP3.INHIBITS.BCL2L1.
type: Catalysis
controlled: Physical.Interaction.I.BNIP3.BCL2L1
control type: INHIBITION
data source: Spike
controller: BNIP3
xref: 10625696

.BIRC2.INHIBITS.CASP9.
type: Catalysis
controlled: Physical.Interaction.I.BIRC2.CASP9
control type: INHIBITION
data source: Spike
controller: BIRC2
xref: 9545235
xref: 9990849

7536190
type: PublicationXref
db: PubMed
title: A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain
id: 7536190

PENK
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5179
organism: Homo sapiens

NFKBIA_RNA
type: RnaRegion
entity reference: NFKBIA

RIPK1
type: Protein
entity reference: RIPK1

NO
type: SmallMoleculeReference
xref: http://www.ebi.ac.uk/chebi/#16480

APAF1_RNA
type: RnaRegion
entity reference: APAF1

http://www.ncbi.nlm.nih.gov/#3600
type: UnificationXref
db: Entrez Gene
id: 3600

CXCL10_RNA
type: RnaRegion
entity reference: CXCL10

ISG15
type: Protein
entity reference: ISG15

CASP8_inactive
type: Protein
entity reference: CASP8

.TRAF2.PROMOTES.RIPK1.
type: Catalysis
controlled: Ubiquitination.P.TRAF2.RIPK1
control type: ACTIVATION
data source: Spike
controller: TRAF2
xref: 8702708
xref: 8612133
xref: 18981220

.STAT3.PROMOTES.MIR181B1.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.STAT3.MIR181B1
xref: 20797623
xref: 21502305
data source: Spike
controller: STAT3

http://www.ncbi.nlm.nih.gov/#3606
type: UnificationXref
db: Entrez Gene
id: 3606

IRF4_RNA
type: RnaRegion
entity reference: IRF4

TRAF2_inactive
type: Protein
entity reference: TRAF2

CCL2_RNA
type: RnaRegion
entity reference: CCL2

10892748
type: PublicationXref
db: PubMed
title: A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction
id: 10892748

19442713
type: PublicationXref
db: PubMed
title: Dexamethasone protects auditory hair cells against TNFalpha-initiated apoptosis via activation of PI3K/Akt and NFkappaB signaling
id: 19442713

CXCL2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2920
organism: Homo sapiens

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.PTGDS.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.PTGDS
xref: 12488457
data source: Spike
controller: NFkB.complex

http://www.ncbi.nlm.nih.gov/#407008
type: UnificationXref
db: Entrez Gene
id: 407008

http://www.ncbi.nlm.nih.gov/#2950
type: UnificationXref
db: Entrez Gene
id: 2950

GADD45B
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4616
organism: Homo sapiens

.BIRC2.INHIBITS.CASP7.
type: Catalysis
controlled: Physical.Interaction.I.BIRC2.CASP7
control type: INHIBITION
data source: Spike
controller: BIRC2
xref: 9384571

PhysicalInteraction [MAP3K7 -- TRAF6 ]
type: MolecularInteraction
participant: MAP3K7
participant: TRAF6
xref: 19232515
xref: 17145710
comment: intact:EBI-525891

BCL2L1
type: Protein
entity reference: BCL2L1

BIRC2_DNA
type: DnaRegion
entity reference: BIRC2

Translation
type: MolecularInteraction
participant: IL12B
participant: IL12B_RNA

8612133
type: PublicationXref
db: PubMed
title: TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex
id: 8612133

CCL2
type: Protein
entity reference: CCL2

19408108
type: PublicationXref
db: PubMed
title: NF-kappaB Signaling in the Aging Process
id: 19408108

NFKB1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4790
organism: Homo sapiens

CCL2_DNA
type: DnaRegion
entity reference: CCL2

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.IL6.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.IL6
xref: 1644898
xref: 2183031
xref: 10501190
data source: Spike
controller: NFkB.complex

IL8_DNA
type: DnaRegion
entity reference: IL8

CD48_DNA
type: DnaRegion
entity reference: CD48

BCL2L1_RNA
type: RnaRegion
entity reference: BCL2L1

12704649
type: PublicationXref
db: PubMed
title: Endothelial activation by angiotensin II through NFkappaB and p38 pathways: Involvement of NFkappaB-inducible kinase (NIK), free oxygen radicals, and selective inhibition by aspirin
id: 12704649

.CASP3.INHIBITS.XIAP.
type: Catalysis
controlled: Protein.Degradation.I.CASP3.XIAP
control type: INHIBITION
data source: Spike
controller: CASP3
xref: 15725726

http://www.ncbi.nlm.nih.gov/#664
type: UnificationXref
db: Entrez Gene
id: 664

NFKBIB
type: Protein
entity reference: NFKBIB

GADD45B_RNA
type: RnaRegion
entity reference: GADD45B

18508759
type: PublicationXref
db: PubMed
title: MKP-1 represses JNK-mediated apoptosis via NF-kappa B regulation
id: 18508759

10562553
type: PublicationXref
db: PubMed
title: Constitutive silencing of IFN-beta promoter is mediated by NRF (NF-kappaB-repressing factor), a nuclear inhibitor of NF-kappaB
id: 10562553

FAS_inactive
type: Protein
entity reference: FAS

.RIPK1.PROMOTES.Complex.IKK..IKBKB,.IKBKG,.CHUK..
type: Catalysis
controlled: Physical.Interaction.P.RIPK1.IKK
control type: ACTIVATION
data source: Spike
controller: RIPK1
xref: 12654725

SELE
type: Protein
entity reference: SELE

CD83_RNA
type: RnaRegion
entity reference: CD83

IL12B_DNA
type: DnaRegion
entity reference: IL12B

10751398
type: PublicationXref
db: PubMed
title: Involvement of two NF-kappa B binding elements in tumor necrosis factor alpha -, CD40-, and epstein-barr virus latent membrane protein 1-mediated induction of the cIAP2
id: 10751398

DUSP1
type: Protein
entity reference: DUSP1

9922454
type: PublicationXref
db: PubMed
title: Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner
id: 9922454

CD48
type: Protein
entity reference: CD48

BAX
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#581
organism: Homo sapiens

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.FASLG.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.FASLG
xref: 9873041
xref: 9660938
xref: 9759866
data source: Spike
controller: NFkB.complex

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.IL8.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.IL8
xref: 12909591
xref: 11418672
data source: Spike
controller: NFkB.complex

9539746
type: PublicationXref
db: PubMed
title: Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation
id: 9539746

17681183
type: PublicationXref
db: PubMed
title: MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
id: 17681183

http://www.ncbi.nlm.nih.gov/#3434
type: UnificationXref
db: Entrez Gene
id: 3434

IKBKE_inactive
type: Protein
entity reference: IKBKE

TNFSF10
type: Protein
entity reference: TNFSF10

.NFKBIA.INHIBITS.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL..(Family.NFkB sub I..NFKB1,.NFKB2.).
type: Catalysis
controlled: Physical.Interaction.I.NFKBIA.NFkB
control type: INHIBITION
data source: Spike
controller: NFKBIA
xref: 21135870

RELB
type: Protein
entity reference: RELB

MMP9_RNA
type: RnaRegion
entity reference: MMP9

NOS2
type: Protein
entity reference: NOS2

CSF2_RNA
type: RnaRegion
entity reference: CSF2

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.ISG15.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.ISG15
xref: 12354379
data source: Spike
controller: NFkB.complex

Translation
type: MolecularInteraction
participant: IER3
participant: IER3_RNA

IL18
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3606
organism: Homo sapiens

IL15_RNA
type: RnaRegion
entity reference: IL15

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.MMP9.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.MMP9
xref: 15169910
data source: Spike
controller: NFkB.complex

STAT3_inactive
type: Protein
entity reference: STAT3

.BIRC2.INHIBITS.CASP3.
type: Catalysis
controlled: Physical.Interaction.I.BIRC2.CASP3
control type: INHIBITION
data source: Spike
controller: BIRC2
xref: 9384571
xref: 9990849
xref: 12042762

12354379
type: PublicationXref
db: PubMed
title: IRF3 mediates a TLR3/TLR4-specific antiviral gene program
id: 12354379

http://www.ncbi.nlm.nih.gov/#3456
type: UnificationXref
db: Entrez Gene
id: 3456

Translation
type: MolecularInteraction
participant: NFKB1_RNA
participant: NFKB1_inactive

VCAM1_RNA
type: RnaRegion
entity reference: VCAM1

12654725
type: PublicationXref
db: PubMed
title: The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation
id: 12654725

LIN28A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#79727
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#1440
type: UnificationXref
db: Entrez Gene
id: 1440

IL8_RNA
type: RnaRegion
entity reference: IL8

CFLAR_DNA
type: DnaRegion
entity reference: CFLAR

http://www.ncbi.nlm.nih.gov/#1437
type: UnificationXref
db: Entrez Gene
id: 1437

CCL20_DNA
type: DnaRegion
entity reference: CCL20

http://www.ncbi.nlm.nih.gov/#6348
type: UnificationXref
db: Entrez Gene
id: 6348

http://www.ncbi.nlm.nih.gov/#207
type: UnificationXref
db: Entrez Gene
id: 207

http://www.ncbi.nlm.nih.gov/#6347
type: UnificationXref
db: Entrez Gene
id: 6347

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.SELE.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.SELE
xref: 9317150
data source: Spike
controller: NFkB.complex

.BIRC3.INHIBITS.CASP9.
type: Catalysis
controlled: Physical.Interaction.I.BIRC3.CASP9
control type: INHIBITION
data source: Spike
controller: BIRC3
xref: 9545235
xref: 9990849

Translation
type: MolecularInteraction
participant: MMP14_RNA
participant: MMP14_inactive

Translation
type: MolecularInteraction
participant: LIN28A
participant: LIN28A_RNA

15725726
type: PublicationXref
db: PubMed
title: Overview of cell death signaling pathways
id: 15725726

8355682
type: PublicationXref
db: PubMed
title: C/EBP, NF-kappa B, and c-Ets family members and transcriptional regulation of the cell-specific and inducible macrophage inflammatory protein 1 alpha immediate-early gene
id: 8355682

IL6_RNA
type: RnaRegion
entity reference: IL6

Translation
type: MolecularInteraction
participant: B2M
participant: B2M_RNA

IL18_DNA
type: DnaRegion
entity reference: IL18

MIR301A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#407027
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#6352
type: UnificationXref
db: Entrez Gene
id: 6352

Translation
type: MolecularInteraction
participant: IRF4
participant: IRF4_RNA

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.MADCAM1.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.MADCAM1
xref: 7724598
data source: Spike
controller: NFkB.complex

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.ICAM1.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.ICAM1
xref: 7907090
data source: Spike
controller: NFkB.complex

FASLG
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#356
organism: Homo sapiens

BNIP3
type: Protein
entity reference: BNIP3

http://www.ncbi.nlm.nih.gov/#6774
type: UnificationXref
db: Entrez Gene
id: 6774

.BCL2L1.INHIBITS.APAF1.
type: Catalysis
controlled: Physical.Interaction.I.BCL2L1.APAF1
control type: INHIBITION
data source: Spike
controller: BCL2L1
xref: 9539746
xref: 9488720

BAX_RNA
type: RnaRegion
entity reference: BAX

EGR1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1958
organism: Homo sapiens

XIAP
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#331
organism: Homo sapiens

mir146 fam.family
type: Protein
data source: Spike
xref: WEB:0002173

ATM
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#472
organism: Homo sapiens

.TRAF2.PROMOTES.Complex.IKK..IKBKB,.IKBKG,.CHUK.(IKBKB).
type: Catalysis
controlled: Physical.Interaction.P.TRAF2.IKK
control type: ACTIVATION
data source: Spike
controller: TRAF2
xref: 10795740

12488457
type: PublicationXref
db: PubMed
title: Regulation of lipocalin-type prostaglandin D synthase gene expression by Hes-1 through E-box and interleukin-1 beta via two NF-kappa B elements in rat leptomeningeal cells
id: 12488457

Translation
type: MolecularInteraction
participant: VCAM1
participant: VCAM1_RNA

14729949
type: PublicationXref
db: PubMed
title: Suppression of PTEN expression by NF-kappa B prevents apoptosis
id: 14729949

.TP53.PROMOTES.BAX.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.TP53.BAX
xref: 7834749
data source: Spike
controller: TP53

http://www.ncbi.nlm.nih.gov/#841
type: UnificationXref
db: Entrez Gene
id: 841

http://www.ncbi.nlm.nih.gov/#842
type: UnificationXref
db: Entrez Gene
id: 842

CCL20
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6364
organism: Homo sapiens

8576166
type: PublicationXref
db: PubMed
title: Glucocorticoid-mediated gene suppression of rat cytokine-induced neutrophil chemoattractant CINC/gro, a member of the interleukin-8 family, through impairment of NF-kappa B activation
id: 8576166

IKBKG
type: Protein
entity reference: IKBKG

http://www.ncbi.nlm.nih.gov/#5071
type: UnificationXref
db: Entrez Gene
id: 5071

http://www.ncbi.nlm.nih.gov/#840
type: UnificationXref
db: Entrez Gene
id: 840

http://www.ncbi.nlm.nih.gov/#6364
type: UnificationXref
db: Entrez Gene
id: 6364

http://www.ncbi.nlm.nih.gov/#7412
type: UnificationXref
db: Entrez Gene
id: 7412

Translation
type: MolecularInteraction
participant: NFKB2_RNA
participant: NFKB2

CYLD_inactive
type: Protein
entity reference: CYLD

7565674
type: PublicationXref
db: PubMed
title: Regulation of interleukin 12 p40 expression through an NF-kappa B half-site
id: 7565674

PTGDS
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5730
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#836
type: UnificationXref
db: Entrez Gene
id: 836

12101257
type: PublicationXref
db: PubMed
title: Role of CXCL1 in tumorigenesis of melanoma
id: 12101257

.CASP3.INHIBITS.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL..(RELA).
type: Catalysis
controlled: Proteolytic.Processing.I.CASP3.NFkB
control type: INHIBITION
data source: Spike
controller: CASP3
xref: 9500443

CCL5
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6352
organism: Homo sapiens

NFKB2
type: Protein
entity reference: NFKB2

NFKBIA_DNA
type: DnaRegion
entity reference: NFKBIA

.BIRC3.INHIBITS.CASP7.
type: Catalysis
controlled: Physical.Interaction.I.BIRC3.CASP7
control type: INHIBITION
data source: Spike
controller: BIRC3
xref: 9384571

SELE
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6401
organism: Homo sapiens

TLR2_DNA
type: DnaRegion
entity reference: TLR2

.CASP9.PROMOTES.CASP3.
type: Catalysis
controlled: Proteolytic.Processing.P.CASP9.CASP3
control type: ACTIVATION
data source: Spike
controller: CASP9
xref: 9390557

CCL20_RNA
type: RnaRegion
entity reference: CCL20

BNIP3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#664
organism: Homo sapiens

SELE_RNA
type: RnaRegion
entity reference: SELE

DUSP1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1843
organism: Homo sapiens

ICAM1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3383
organism: Homo sapiens

9601937
type: PublicationXref
db: PubMed
title: The NF-kappaB binding site is essential for transcriptional activation of the IL-15 gene
id: 9601937

TP53
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7157
organism: Homo sapiens

.TRADD.PROMOTES.TRAF2.
type: Catalysis
controlled: Physical.Interaction.P.TRADD.TRAF2
control type: ACTIVATION
data source: Spike
controller: TRADD
xref: 10892748
xref: 8702708
xref: 8565075

Translation
type: MolecularInteraction
participant: GSTP1
participant: GSTP1_RNA

FADD_inactive
type: Protein
entity reference: FADD

Translation
type: MolecularInteraction
participant: IFNB1_RNA
participant: IFNB1

.MMP14.PROMOTES.MMP2.
type: Catalysis
controlled: Other.P.MMP14.MMP2
control type: ACTIVATION
data source: Spike
controller: MMP14
xref: 11857380

VCAM1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7412
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#8517
type: UnificationXref
db: Entrez Gene
id: 8517

Translation
type: MolecularInteraction
participant: MIR29A
participant: MIR29A_RNA

7541912
type: PublicationXref
db: PubMed
title: Structural and functional characterization of the promoter regions of the NFKB2 gene
id: 7541912

http://www.ncbi.nlm.nih.gov/#9641
type: UnificationXref
db: Entrez Gene
id: 9641

IER3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8870
organism: Homo sapiens

SOCS1_RNA
type: RnaRegion
entity reference: SOCS1

NOS2_RNA
type: RnaRegion
entity reference: NOS2

http://www.ncbi.nlm.nih.gov/#3627
type: UnificationXref
db: Entrez Gene
id: 3627

11709054
type: PublicationXref
db: PubMed
title: Mechanisms of p53-dependent apoptosis
id: 11709054

CSF2
type: Protein
entity reference: CSF2

MMP14_DNA
type: DnaRegion
entity reference: MMP14

.PTEN.INHIBITS.AKT1.
type: Catalysis
controlled: Indirect.I.PTEN.AKT1
control type: INHIBITION
data source: Spike
controller: PTEN
xref: 15184909

NO
type: SmallMolecule
entity reference: NO

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.GADD45B.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.GADD45B
xref: 12162804
data source: Spike
controller: NFkB.complex

B2M
type: Protein
entity reference: B2M

10215868
type: PublicationXref
db: PubMed
title: NFkappaB activation is required for interferon regulatory factor-1-mediated interferon beta induction
id: 10215868

.CYLD.INHIBITS.TRAF2.
type: Catalysis
controlled: Deubiqitination.I.CYLD.TRAF2
control type: INHIBITION
data source: Spike
controller: CYLD
xref: 12917691

http://www.ncbi.nlm.nih.gov/#9636
type: UnificationXref
db: Entrez Gene
id: 9636

CXCL1
type: Protein
entity reference: CXCL1

15173180
type: PublicationXref
db: PubMed
title: Direct binding of Fas-associated death domain (FADD) to the tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 is regulated by the death effector domain of FADD
id: 15173180

IFNB1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3456
organism: Homo sapiens

.MIR155.INHIBITS.IKBKE.
type: Catalysis
controlled: mRNA.stability.I.MIR155.IKBKE
control type: INHIBITION
data source: Spike
controller: MIR155
xref: 19650740
xref: 21502305
xref: 17911593

.TNFSF10.PROMOTES.TNFRSF10B.
type: Catalysis
controlled: Physical.Interaction.P.TNFSF10.TNFRSF10B
control type: ACTIVATION
data source: Spike
controller: TNFSF10
xref: 15538968

IKBKG
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8517
organism: Homo sapiens

.SIRT1.INHIBITS.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL..(RELB).
type: Catalysis
controlled: Deacetylation.I.SIRT1.NFkB
control type: INHIBITION
data source: Spike
controller: SIRT1
xref: 19408108
xref: 15152190
xref: 18193389

Translation
type: MolecularInteraction
participant: GADD45B
participant: GADD45B_RNA

MADCAM1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8174
organism: Homo sapiens

1990263
type: PublicationXref
db: PubMed
title: Nuclear factor kappa B activates proenkephalin transcription in T lymphocytes
id: 1990263

MIR29B1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#407024
organism: Homo sapiens

FAS_DNA
type: DnaRegion
entity reference: FAS

http://www.ncbi.nlm.nih.gov/#472
type: UnificationXref
db: Entrez Gene
id: 472

http://www.ncbi.nlm.nih.gov/#4790
type: UnificationXref
db: Entrez Gene
id: 4790

http://www.ncbi.nlm.nih.gov/#4791
type: UnificationXref
db: Entrez Gene
id: 4791

SIRT1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#23411
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#4792
type: UnificationXref
db: Entrez Gene
id: 4792

http://www.ncbi.nlm.nih.gov/#4793
type: UnificationXref
db: Entrez Gene
id: 4793

http://www.ncbi.nlm.nih.gov/#4794
type: UnificationXref
db: Entrez Gene
id: 4794

http://www.ncbi.nlm.nih.gov/#3662
type: UnificationXref
db: Entrez Gene
id: 3662

CFLAR_RNA
type: RnaRegion
entity reference: CFLAR

Translation
type: MolecularInteraction
participant: BCL2A1
participant: BCL2A1_RNA

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.BCL2L1.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.BCL2L1
xref: 10085086
data source: Spike
controller: NFkB.complex

.BIRC3.INHIBITS.CASP3.
type: Catalysis
controlled: Physical.Interaction.I.BIRC3.CASP3
control type: INHIBITION
data source: Spike
controller: BIRC3
xref: 9384571
xref: 9990849
xref: 12042762

.Family.HSP70....INHIBITS.Complex.IKK..IKBKB,.IKBKG,.CHUK.(IKBKG).
type: Catalysis
controlled: Physical.Interaction.I.HSP70.IKK
control type: INHIBITION
data source: Spike
controller: HSP70.family
xref: 18282612

11121152
type: PublicationXref
db: PubMed
title: Dysregulated activation of activator protein 1 in keratinocytes of atopic dermatitis patients with enhanced expression of granulocyte/macrophage-colony stimulating factor
id: 11121152

CXCL1_DNA
type: DnaRegion
entity reference: CXCL1

9228058
type: PublicationXref
db: PubMed
title: Characterization of Fas (Apo-1, CD95)-Fas ligand interaction
id: 9228058

http://www.ncbi.nlm.nih.gov/#3659
type: UnificationXref
db: Entrez Gene
id: 3659

9230442
type: PublicationXref
db: PubMed
title: X-linked IAP is a direct inhibitor of cell-death proteases
id: 9230442

.CYLD.INHIBITS.TRAF6.
type: Catalysis
controlled: Deubiqitination.I.CYLD.TRAF6
control type: INHIBITION
data source: Spike
controller: CYLD
xref: 12917691

MMP2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4313
organism: Homo sapiens

PTEN_inactive
type: Protein
entity reference: PTEN

Translation
type: MolecularInteraction
participant: DUSP1_RNA
participant: DUSP1

.Family.IkB..NFKBIA,.NFKBIB,.NFKBIE..INHIBITS.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...
type: Catalysis
controlled: Physical.Interaction.I.IkB.NFkB
control type: INHIBITION
data source: Spike
controller: IkB.family
xref: 10644043

Translation
type: MolecularInteraction
participant: IL6_RNA
participant: IL6

10795740
type: PublicationXref
db: PubMed
title: The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation
id: 10795740

8021507
type: PublicationXref
db: PubMed
title: NF-kappa B regulates IL-1 beta transcription through a consensus NF-kappa B binding site and a nonconsensus CRE-like site
id: 8021507

Translation
type: MolecularInteraction
participant: CCL20
participant: CCL20_RNA

9990849
type: PublicationXref
db: PubMed
title: IAP family proteins--suppressors of apoptosis
id: 9990849

MMP2
type: Protein
entity reference: MMP2

11112697
type: PublicationXref
db: PubMed
title: TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa)B mediated induction of MT1-MMP
id: 11112697

http://www.ncbi.nlm.nih.gov/#8737
type: UnificationXref
db: Entrez Gene
id: 8737

9153240
type: PublicationXref
db: PubMed
title: Nonionic detergents induce dimerization among members of the Bcl-2 family
id: 9153240

Translation
type: MolecularInteraction
participant: CXCL1
participant: CXCL1_RNA

CHUK
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1147
organism: Homo sapiens

IL6
type: Protein
entity reference: IL6

.FADD.PROMOTES.RIPK1.
type: Catalysis
controlled: Physical.Interaction.P.FADD.RIPK1
control type: ACTIVATION
data source: Spike
controller: FADD
xref: 18485876

MADCAM1
type: Protein
entity reference: MADCAM1

19906824
type: PublicationXref
db: PubMed
title: microRNA 21: response to hormonal therapies and regulatory function in leiomyoma, transformed leiomyoma and leiomyosarcoma cells
id: 19906824

CCL2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6347
organism: Homo sapiens

TNFAIP3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7128
organism: Homo sapiens

NKRF
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#55922
organism: Homo sapiens

DUSP1_RNA
type: RnaRegion
entity reference: DUSP1

IL15
type: Protein
entity reference: IL15

IKBKE
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#9641
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#8743
type: UnificationXref
db: Entrez Gene
id: 8743

.RELA.INHIBITS.PTEN.
type: Catalysis
controlled: Indirect.I.RELA.PTEN
control type: INHIBITION
data source: Spike
controller: RELA
xref: 14729949

16885212
type: PublicationXref
db: PubMed
title: NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
id: 16885212

17093053
type: PublicationXref
db: PubMed
title: Global mapping of c-Myc binding sites and target gene networks in human B cells
id: 17093053

TNF_DNA
type: DnaRegion
entity reference: TNF

IFNB1
type: Protein
entity reference: IFNB1

CCL5_RNA
type: RnaRegion
entity reference: CCL5

21171089
type: PublicationXref
db: PubMed
title: IKBKE is over-expressed in glioma and contributes to resistance of glioma cells to apoptosis via activating NF-B
id: 21171089

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.TNFAIP3.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.TNFAIP3
xref: 20599425
xref: 12167698
data source: Spike
controller: NFkB.complex

MIR223
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#407008
organism: Homo sapiens

Translation
type: MolecularInteraction
participant: NFkB.complex_RNA
participant: NFkB.complex_inactive

CASP7
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#840
organism: Homo sapiens

.Family.mir.199a....INHIBITS.IKBKB.
type: Catalysis
controlled: N/A.I.mir.199a.IKBKB
control type: INHIBITION
data source: Spike
controller: mir-199a.family
xref: 18408758

TNFRSF10B
type: Protein
entity reference: TNFRSF10B

TRAF6
type: Protein
entity reference: TRAF6

15081318
type: PublicationXref
db: PubMed
title: Regulation of monocyte chemoattractant protein-1 by the oxidized lipid, 13-hydroperoxyoctadecadienoic acid, in vascular smooth muscle cells via nuclear factor-kappa B (NF-kappa B)
id: 15081318

7608567
type: PublicationXref
db: PubMed
title: Transcriptional activation of the human TNF-alpha promoter by superantigen in human monocytic cells: role of NF-kappa B
id: 7608567

10634209
type: PublicationXref
db: PubMed
title: TNF-induced signaling in apoptosis
id: 10634209

.NFKBIZ.INHIBITS.STAT3.
type: Catalysis
controlled: Physical.Interaction.I.NFKBIZ.STAT3
control type: INHIBITION
data source: Spike
controller: NFKBIZ
xref: 19595668

.TNFAIP3.INHIBITS.IKBKG.
type: Catalysis
controlled: Deubiqitination.I.TNFAIP3.IKBKG
control type: INHIBITION
data source: Spike
controller: TNFAIP3
xref: 20932475

Translation
type: MolecularInteraction
participant: IL8_RNA
participant: IL8

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.IL18.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.IL18
xref: 12684057
xref: 11377701
data source: Spike
controller: NFkB.complex

Translation
type: MolecularInteraction
participant: TNFAIP3_RNA
participant: TNFAIP3

1916897
type: PublicationXref
db: PubMed
title: Transcriptional and post-transcriptional mechanisms involved in the differential expression of LPS-induced IL-1 and TNF mRNA
id: 1916897

TNF
type: Protein
entity reference: TNF

.XIAP.INHIBITS.CASP3.
type: Catalysis
controlled: Ubiquitination.I.XIAP.CASP3
control type: INHIBITION
data source: Spike
controller: XIAP
xref: 9230442
xref: 9525868
xref: 11447297
xref: 11927604

16360037
type: PublicationXref
db: PubMed
title: PIDD mediates NF-kappaB activation in response to DNA damage
id: 16360037

PENK
type: Protein
entity reference: PENK

1740105
type: PublicationXref
db: PubMed
title: The characterization of the promoter of the gene encoding the p50 subunit of NF-kappa B indicates that it participates in its own regulation
id: 1740105

9500443
type: PublicationXref
db: PubMed
title: CD95 (Fas)-induced caspase-mediated proteolysis of NF-kappaB
id: 9500443

http://www.ncbi.nlm.nih.gov/#3593
type: UnificationXref
db: Entrez Gene
id: 3593

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.SOCS1.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.SOCS1
xref: 14668806
data source: Spike
controller: NFkB.complex

9384571
type: PublicationXref
db: PubMed
title: The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
id: 9384571

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.IL15.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.IL15
xref: 9601937
data source: Spike
controller: NFkB.complex

http://www.ncbi.nlm.nih.gov/#8174
type: UnificationXref
db: Entrez Gene
id: 8174

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.IRF4.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.IRF4
xref: 10770796
data source: Spike
controller: NFkB.complex

Translation
type: MolecularInteraction
participant: APAF1_inactive
participant: APAF1_RNA

NFKB1_DNA
type: DnaRegion
entity reference: NFKB1

11254708
type: PublicationXref
db: PubMed
title: NF-kappa B and STAT5 play important roles in the regulation of mouse Toll-like receptor 2 gene expression
id: 11254708

TNFRSF1A_inactive
type: Protein
entity reference: TNFRSF1A

http://www.ncbi.nlm.nih.gov/#64332
type: UnificationXref
db: Entrez Gene
id: 64332

CCL5_DNA
type: DnaRegion
entity reference: CCL5

TNF
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7124
organism: Homo sapiens

11447297
type: PublicationXref
db: PubMed
title: Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death
id: 11447297

IKBKG_inactive
type: Protein
entity reference: IKBKG

IL6
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3569
organism: Homo sapiens

CASP3
type: Protein
entity reference: CASP3

20599425
type: PublicationXref
db: PubMed
title: Expression, biological activities and mechanisms of action of A20 (TNFAIP3)
id: 20599425

NFKBIZ
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#64332
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#8717
type: UnificationXref
db: Entrez Gene
id: 8717

18981220
type: PublicationXref
db: PubMed
title: TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis
id: 18981220

11390657
type: PublicationXref
db: PubMed
title: Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family
id: 11390657

19878981
type: PublicationXref
db: PubMed
title: An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation
id: 19878981

REL
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5966
organism: Homo sapiens

Translation
type: MolecularInteraction
participant: EGR1_RNA
participant: EGR1

10756005
type: PublicationXref
db: PubMed
title: Adenovirus vector-induced expression of the C-X-C chemokine IP-10 is mediated through capsid-dependent activation of NF-kappaB
id: 10756005

Translation
type: MolecularInteraction
participant: CFLAR_RNA
participant: CFLAR

10343541
type: PublicationXref
db: PubMed
title: Thrombin receptor mediated signals induce expressions of interleukin 6 and granulocyte colony stimulating factor via NF-kappa B activation in synovial fibroblasts
id: 10343541

15169910
type: PublicationXref
db: PubMed
title: Coordination of cell signaling, chromatin remodeling, histone modifications, and regulator recruitment in human matrix metalloproteinase 9 gene transcription
id: 15169910

IkB.family
type: Protein
data source: Spike
xref: TAU:F.000012
member physical entity: NFKBIE
member physical entity: NFKBIA
member physical entity: NFKBIB

BCL2-fam.family
type: Protein
data source: Spike
xref: TAU:F.000015
member physical entity: BCL2A1
member physical entity: BCL2
member physical entity: BCL2L1

TRAF2_DNA
type: DnaRegion
entity reference: TRAF2

TNFAIP3_RNA
type: RnaRegion
entity reference: TNFAIP3

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.B2M.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.B2M
xref: 8468472
xref: 12221085
data source: Spike
controller: NFkB.complex

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...INHIBITS.MIR29B1.
type: TemplateReactionRegulation
control type: INHIBITION
controlled: Transcription.Regulation.I.NFkB.MIR29B1
xref: 20564213
data source: Spike
controller: NFkB.complex

RIPK1_inactive
type: Protein
entity reference: RIPK1

Translation
type: MolecularInteraction
participant: CSF3
participant: CSF3_RNA

.XIAP.INHIBITS.CASP9.
type: Catalysis
controlled: Physical.Interaction.I.XIAP.CASP9
control type: INHIBITION
data source: Spike
controller: XIAP
xref: 11927604
xref: 12042762
xref: 11390657

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.DUSP1.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.DUSP1
xref: 18508759
data source: Spike
controller: NFkB.complex

STAT3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6774
organism: Homo sapiens

REL
type: Protein
entity reference: REL

12697414
type: PublicationXref
db: PubMed
title: Proinflammatory cytokines induce NF-kappaB-dependent/NO-independent chemokine gene expression in MIN6 beta cells
id: 12697414

9606
type: UnificationXref
db: taxonomy
id: 9606

Translation
type: MolecularInteraction
participant: IL1B
participant: IL1B_RNA

IL6_DNA
type: DnaRegion
entity reference: IL6

12684057
type: PublicationXref
db: PubMed
title: TNF-alpha and H2O2 induce IL-18 and IL-18R beta expression in cardiomyocytes via NF-kappa B activation
id: 12684057

18495079
type: PublicationXref
db: PubMed
title: Nitric oxide-induced resistance or sensitization to death in tumor cells
id: 18495079

http://www.ncbi.nlm.nih.gov/#1843
type: UnificationXref
db: Entrez Gene
id: 1843

.NKRF.INHIBITS.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL..(Family.NFkB sub I..NFKB1,.NFKB2.).
type: Catalysis
controlled: Physical.Interaction.I.NKRF.NFkB
control type: INHIBITION
data source: Spike
controller: NKRF
xref: 10562553

RELA
type: Protein
entity reference: RELA

19232515
type: PublicationXref
db: PubMed
title: An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway
id: 19232515

9712833
type: PublicationXref
db: PubMed
title: Cytokine-mediated transcriptional induction of the human inducible nitric oxide synthase gene requires both activator protein 1 and nuclear factor kappaB-binding sites
id: 9712833

19136941
type: PublicationXref
db: PubMed
title: The role of Bcl-2 family member BNIP3 in cell death and disease: NIPping at the heels of cell death
id: 19136941

12909591
type: PublicationXref
db: PubMed
title: Differential roles for NF-kappa B in endotoxin and oxygen induction of interleukin-8 in the macrophage
id: 12909591

TRADD
type: Protein
entity reference: TRADD

TRAF2
type: Protein
entity reference: TRAF2

10085086
type: PublicationXref
db: PubMed
title: Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons
id: 10085086

.BCL2L1.INHIBITS.BAX.
type: Catalysis
controlled: Physical.Interaction.I.BCL2L1.BAX
control type: INHIBITION
data source: Spike
controller: BCL2L1
xref: 9742125
xref: 9153240
xref: 11283018
xref: 9111042
xref: 18178565

CASP3_inactive
type: Protein
entity reference: CASP3

PTEN
type: Protein
entity reference: PTEN

NFKB1_inactive
type: Protein
entity reference: NFKB1

.TRAF2.PROMOTES.BIRC2.
type: Catalysis
controlled: Physical.Interaction.P.TRAF2.BIRC2
control type: ACTIVATION
data source: Spike
controller: TRAF2
xref: 18981220

SELE_DNA
type: DnaRegion
entity reference: SELE

BCL2L1_DNA
type: DnaRegion
entity reference: BCL2L1

9742085
type: PublicationXref
db: PubMed
title: Tumor necrosis factor alpha transcription in macrophages is attenuated by an autocrine factor that preferentially induces NF-kappaB p50
id: 9742085

.MIR301A.INHIBITS.NKRF.
type: Catalysis
controlled: mRNA.stability.I.MIR301A.NKRF
control type: INHIBITION
data source: Spike
controller: MIR301A
xref: 21502305

CD83
type: Protein
entity reference: CD83

IL8
type: Protein
entity reference: IL8

NFkB.complex_inactive
type: Protein

mir-9.family
type: Protein
data source: Spike
xref: TAU:F.329924

Translation
type: MolecularInteraction
participant: IL15_RNA
participant: IL15

17129668
type: PublicationXref
db: PubMed
title: STAT3 as a central mediator of neoplastic cellular transformation
id: 17129668

http://www.ncbi.nlm.nih.gov/#3383
type: UnificationXref
db: Entrez Gene
id: 3383

MIR155
type: Protein
entity reference: MIR155

TLR2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7097
organism: Homo sapiens

.MIR15A.INHIBITS.CHUK.
type: Catalysis
controlled: mRNA.stability.I.MIR15A.CHUK
control type: INHIBITION
data source: Spike
controller: MIR15A
xref: 20711193
xref: 21502305

GSTP1
type: Protein
entity reference: GSTP1

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.VCAM1.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.VCAM1
xref: 12704649
data source: Spike
controller: NFkB.complex

B2M_DNA
type: DnaRegion
entity reference: B2M

http://www.ncbi.nlm.nih.gov/#2920
type: UnificationXref
db: Entrez Gene
id: 2920

7937093
type: PublicationXref
db: PubMed
title: Three NF-kappa B sites in the I kappa B-alpha promoter are required for induction of gene expression by TNF alpha
id: 7937093

BIRC2_RNA
type: RnaRegion
entity reference: BIRC2

10926836
type: PublicationXref
db: PubMed
title: Tumour necrosis factor-alpha and interferon-gamma synergistically activate the RANTES promoter through nuclear factor kappaB and interferon regulatory factor 1 (IRF-1) transcription factors
id: 10926836

MIR29A_DNA
type: DnaRegion
entity reference: MIR29A

IFIT1
type: Protein
entity reference: IFIT1

NFKB2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4791
organism: Homo sapiens

PTEN
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5728
organism: Homo sapiens

.IKBKE.INHIBITS.NFKBIA.
type: Catalysis
controlled: Phosphorylation.I.IKBKE.NFKBIA
control type: INHIBITION
data source: Spike
controller: IKBKE
xref: 10421793
xref: 21171089
xref: 21872579

http://www.ncbi.nlm.nih.gov/#2919
type: UnificationXref
db: Entrez Gene
id: 2919

NFKB2_DNA
type: DnaRegion
entity reference: NFKB2

15818404
type: PublicationXref
db: PubMed
title: Protein kinase CK2 phosphorylates and upregulates Akt/PKB
id: 15818404

MIR29A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#407021
organism: Homo sapiens

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.IL12B.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.IL12B
xref: 7565674
data source: Spike
controller: NFkB.complex

8546677
type: PublicationXref
db: PubMed
title: The organization of the human GSTP1-1 gene promoter and its response to retinoic acid and cellular redox status
id: 8546677

Translation
type: MolecularInteraction
participant: BCL2_RNA
participant: BCL2

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.CXCL10.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.CXCL10
xref: 12697414
xref: 9788276
xref: 10756005
data source: Spike
controller: NFkB.complex

9126929
type: PublicationXref
db: PubMed
title: Identification of amino acid residues important for ligand binding to Fas
id: 9126929

MMP2_inactive
type: Protein
entity reference: MMP2

.IRF1.PROMOTES.NOS2.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.IRF1.NOS2
xref: 9988718
data source: Spike
controller: IRF1

.Family.mir146.fam....INHIBITS.TRAF6.
type: Catalysis
controlled: mRNA.stability.I.mir146.fam.TRAF6
control type: INHIBITION
data source: Spike
controller: mir146 fam.family
xref: 16885212
xref: 21502305

MIR29A
type: Protein
entity reference: MIR29A

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.IL10.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.IL10
xref: 8704212
data source: Spike
controller: NFkB.complex

RIPK1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8737
organism: Homo sapiens

TRADD
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8717
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#8772
type: UnificationXref
db: Entrez Gene
id: 8772

.APAF1.PROMOTES.CASP9.
type: Catalysis
controlled: Physical.Interaction.P.APAF1.CASP9
control type: ACTIVATION
data source: Spike
controller: APAF1
xref: 9922454
xref: 9488720

Translation
type: MolecularInteraction
participant: TNF
participant: TNF_RNA

BIRC2
type: Protein
entity reference: BIRC2

TNF_RNA
type: RnaRegion
entity reference: TNF

GSTP1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2950
organism: Homo sapiens

FASLG_DNA
type: DnaRegion
entity reference: FASLG

Translation
type: MolecularInteraction
participant: PTGDS
participant: PTGDS_RNA

http://www.ncbi.nlm.nih.gov/#23411
type: UnificationXref
db: Entrez Gene
id: 23411

Translation
type: MolecularInteraction
participant: IL18
participant: IL18_RNA

CSF3
type: Protein
entity reference: CSF3

1644898
type: PublicationXref
db: PubMed
title: Cytokine regulation of interleukin-6 gene expression in astrocytes involves activation of an NF-kappa B-like nuclear protein
id: 1644898

BCL2L1_inactive
type: Protein
entity reference: BCL2L1

.Complex.HSP90.CDC37....PROMOTES.Complex.IKK..IKBKB,.IKBKG,.CHUK.(IKBKG).
type: Catalysis
controlled: Physical.Interaction.P.HSP90.CDC37.IKK
control type: ACTIVATION
data source: Spike
controller: HSP90-CDC37.complex
xref: 18282612

.PTEN.INHIBITS.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL..(Family.NFkB sub II..RELA,.RELB,.REL.).
type: Catalysis
controlled: Indirect.I.PTEN.NFkB
control type: INHIBITION
data source: Spike
controller: PTEN
xref: 14729949

.TNFRSF10B.PROMOTES.FADD.
type: Catalysis
controlled: Physical.Interaction.P.TNFRSF10B.FADD
control type: ACTIVATION
data source: Spike
controller: TNFRSF10B
xref: 9430227
xref: 9430228
xref: 15173180

10421793
type: PublicationXref
db: PubMed
title: IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases
id: 10421793

http://www.ncbi.nlm.nih.gov/#8795
type: UnificationXref
db: Entrez Gene
id: 8795

SOCS1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8651
organism: Homo sapiens

PTGS2_DNA
type: DnaRegion
entity reference: PTGS2

9430227
type: PublicationXref
db: PubMed
title: Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway
id: 9430227

11927604
type: PublicationXref
db: PubMed
title: The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites
id: 11927604

9430228
type: PublicationXref
db: PubMed
title: TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB
id: 9430228

21872579
type: PublicationXref
db: PubMed
title: Importance of PIKKs in NF-B activation by genotoxic stress
id: 21872579

CASP3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#836
organism: Homo sapiens

IL18_RNA
type: RnaRegion
entity reference: IL18

11377701
type: PublicationXref
db: PubMed
title: Regulation of IL-18 production by IFN gamma and PGE2 in mouse microglial cells: involvement of NF-kB pathway in the regulatory processes
id: 11377701

11857380
type: PublicationXref
db: PubMed
title: Expression of membrane type 1 matrix metalloproteinase (MT1-MMP) in A2058 melanoma cells is associated with MMP-2 activation and increased tumor growth and vascularization
id: 11857380

NFkB_sub_I.family
type: Protein
data source: Spike
xref: TAU:F.000004
member physical entity: NFKB1
member physical entity: NFKB2

http://www.ncbi.nlm.nih.gov/#6401
type: UnificationXref
db: Entrez Gene
id: 6401

NFKB1
type: Protein
entity reference: NFKB1

NFKBIA
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4792
organism: Homo sapiens

APAF1
type: Protein
entity reference: APAF1

11283018
type: PublicationXref
db: PubMed
title: In vitro selection and characterization of Bcl-X(L)-binding proteins from a mix of tissue-specific mRNA display libraries
id: 11283018

http://www.ncbi.nlm.nih.gov/#8651
type: UnificationXref
db: Entrez Gene
id: 8651

7538907
type: PublicationXref
db: PubMed
title: FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
id: 7538907

FASLG_RNA
type: RnaRegion
entity reference: FASLG

8702708
type: PublicationXref
db: PubMed
title: Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins
id: 8702708

Translation
type: MolecularInteraction
participant: BCL2L1_inactive
participant: BCL2L1_RNA

BCL2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#596
organism: Homo sapiens

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.TRAF2.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.TRAF2
xref: 9733516
data source: Spike
controller: NFkB.complex

.Complex.IKK..IKBKB,.IKBKG,.CHUK..INHIBITS.Family.IkB..NFKBIA,.NFKBIB,.NFKBIE..
type: Catalysis
controlled: Phosphorylation.I.IKK.IkB
control type: INHIBITION
data source: Spike
controller: IKK.complex
xref: 10644043

.PARK2.PROMOTES.IKBKG.
type: Catalysis
controlled: Ubiquitination.P.PARK2.IKBKG
control type: ACTIVATION
data source: Spike
controller: PARK2
xref: 20301198

20932475
type: PublicationXref
db: PubMed
title: A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-B activation
id: 20932475

MIR29A_RNA
type: RnaRegion
entity reference: MIR29A

Translation
type: MolecularInteraction
participant: NOS2
participant: NOS2_RNA

Translation
type: MolecularInteraction
participant: BIRC3
participant: BIRC3_RNA

MYC
type: Protein
entity reference: MYC

12860389
type: PublicationXref
db: PubMed
title: IL-1beta-dependent activation of NF-kappaB mediates PGE2 release via the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase
id: 12860389

PTGDS_DNA
type: DnaRegion
entity reference: PTGDS

11423996
type: PublicationXref
db: PubMed
title: DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1
id: 11423996

http://www.ncbi.nlm.nih.gov/#9308
type: UnificationXref
db: Entrez Gene
id: 9308

21135870
type: PublicationXref
db: PubMed
title: Structural studies of NF-B signaling
id: 21135870

AKT1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#207
organism: Homo sapiens

Translation
type: MolecularInteraction
participant: PTGS2_RNA
participant: PTGS2

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.IL1B.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.IL1B
xref: 8021507
xref: 8413223
data source: Spike
controller: NFkB.complex

.TRADD.PROMOTES.RIPK1.
type: Catalysis
controlled: Physical.Interaction.P.TRADD.RIPK1
control type: ACTIVATION
data source: Spike
controller: TRADD
xref: 8612133

SOCS1
type: Protein
entity reference: SOCS1

.EGR1.PROMOTES.PTEN.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.EGR1.PTEN
xref: 12384981
data source: Spike
controller: EGR1

.FADD.PROMOTES.CASP8.
type: Catalysis
controlled: Physical.Interaction.P.FADD.CASP8
control type: ACTIVATION
data source: Spike
controller: FADD
xref: 8681376

NFKB2_RNA
type: RnaRegion
entity reference: NFKB2

ISG15_RNA
type: RnaRegion
entity reference: ISG15

8468472
type: PublicationXref
db: PubMed
title: Regulation of MHC class I and beta 2-microglobulin gene expression in human neuronal cells. Factor binding to conserved cis-acting regulatory sequences correlates with expression of the genes
id: 8468472

12221085
type: PublicationXref
db: PubMed
title: IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program
id: 12221085

19595668
type: PublicationXref
db: PubMed
title: Nuclear protein IkappaB-zeta inhibits the activity of STAT3
id: 19595668

MADCAM1_DNA
type: DnaRegion
entity reference: MADCAM1

CASP7
type: Protein
entity reference: CASP7

TNFSF10
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8743
organism: Homo sapiens

STAT3
type: Protein
entity reference: STAT3

http://www.ncbi.nlm.nih.gov/#406991
type: UnificationXref
db: Entrez Gene
id: 406991

http://www.ncbi.nlm.nih.gov/#55922
type: UnificationXref
db: Entrez Gene
id: 55922

CHUK
type: Protein
entity reference: CHUK

Translation
type: MolecularInteraction
participant: TLR2
participant: TLR2_RNA

20797623
type: PublicationXref
db: PubMed
title: STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer
id: 20797623

.STAT3.PROMOTES.MIR21.
type: Catalysis
controlled: mRNA.stability.P.STAT3.MIR21
control type: ACTIVATION
data source: Spike
controller: STAT3
xref: 20797623

11418672
type: PublicationXref
db: PubMed
title: IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kappa B and activator protein-2
id: 11418672

IL12B
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3593
organism: Homo sapiens

11343293
type: PublicationXref
db: PubMed
title: Regulation of the gene encoding the monocyte chemoattractant protein 1 (MCP-1) in the mouse and rat brain in response to circulating LPS and proinflammatory cytokines
id: 11343293

NKRF_inactive
type: Protein
entity reference: NKRF

11437602
type: PublicationXref
db: PubMed
title: [W206R]-procaspase 3: an inactivatable substrate for caspase 8
id: 11437602

CASP9_inactive
type: Protein
entity reference: CASP9

http://www.ncbi.nlm.nih.gov/#7157
type: UnificationXref
db: Entrez Gene
id: 7157

11995880
type: PublicationXref
db: PubMed
title: Requirements for NF-kappaB activation in hemorrhagic shock
id: 11995880

MIR223
type: Protein
entity reference: MIR223

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.PENK.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.PENK
xref: 1990263
data source: Spike
controller: NFkB.complex

NFKBIE
type: Protein
entity reference: NFKBIE

IL1B_RNA
type: RnaRegion
entity reference: IL1B

HSP70.family
type: Protein
data source: Spike
xref: CEN:F.329896

NFKBIZ
type: Protein
entity reference: NFKBIZ

CYLD
type: Protein
entity reference: CYLD

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.NOS2.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.NOS2
xref: 9712833
data source: Spike
controller: NFkB.complex

12857898
type: PublicationXref
db: PubMed
title: Latent membrane protein 1 of Epstein-Barr virus induces CD83 by the NF-kappaB signaling pathway
id: 12857898

CASP8
type: Protein
entity reference: CASP8

IKBKB_inactive
type: Protein
entity reference: IKBKB

IRF4
type: Protein
entity reference: IRF4

http://www.ncbi.nlm.nih.gov/#4843
type: UnificationXref
db: Entrez Gene
id: 4843

ATM
type: Protein
entity reference: ATM

7724598
type: PublicationXref
db: PubMed
title: Induction of the gene encoding mucosal vascular addressin cell adhesion molecule 1 by tumor necrosis factor alpha is mediated by NF-kappa B proteins
id: 7724598

PENK_RNA
type: RnaRegion
entity reference: PENK

15152190
type: PublicationXref
db: PubMed
title: Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
id: 15152190

BCL2_RNA
type: RnaRegion
entity reference: BCL2

IKBKB
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3551
organism: Homo sapiens

PTGS2_RNA
type: RnaRegion
entity reference: PTGS2

ISG15
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#9636
organism: Homo sapiens

.MYC.INHIBITS.NFKB2.
type: TemplateReactionRegulation
control type: INHIBITION
controlled: Transcription.Regulation.I.MYC.NFKB2
xref: 17093053
data source: Spike
controller: MYC

BCL2L1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#598
organism: Homo sapiens

18178565
type: PublicationXref
db: PubMed
title: Differential regulation of Bax and Bak by anti-apoptotic Bcl-2 family proteins Bcl-B and Mcl-1
id: 18178565

IFIT1_RNA
type: RnaRegion
entity reference: IFIT1

IFIT1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3434
organism: Homo sapiens

Translation
type: MolecularInteraction
participant: CXCL2_RNA
participant: CXCL2

.LRDD.PROMOTES.IKBKG.
type: Catalysis
controlled: Physical.Interaction.P.LRDD.IKBKG
control type: ACTIVATION
data source: Spike
controller: LRDD
xref: 16360037

GADD45B_DNA
type: DnaRegion
entity reference: GADD45B

Collagen-IV.family
type: Protein
data source: Spike
xref: ELK:F.329909

17138645
type: PublicationXref
db: PubMed
title: Reciprocal cross talk between gonadotropin-releasing hormone (GnRH) and prostaglandin receptors regulates GnRH receptor expression and differential gonadotropin secretion
id: 17138645

http://www.ncbi.nlm.nih.gov/#7186
type: UnificationXref
db: Entrez Gene
id: 7186

PTGDS
type: Protein
entity reference: PTGDS

http://www.ncbi.nlm.nih.gov/#7189
type: UnificationXref
db: Entrez Gene
id: 7189

Translation
type: MolecularInteraction
participant: IFIT1
participant: IFIT1_RNA

CCL20
type: Protein
entity reference: CCL20

12414801
type: PublicationXref
db: PubMed
title: ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3alpha gene expression in Caco-2 human colonic epithelial cells
id: 12414801

Homo sapiens
type: BioSource
xref: 9606

Translation
type: MolecularInteraction
participant: SELE_RNA
participant: SELE

http://www.ncbi.nlm.nih.gov/#962
type: UnificationXref
db: Entrez Gene
id: 962

MMP14_RNA
type: RnaRegion
entity reference: MMP14

http://www.ncbi.nlm.nih.gov/#3576
type: UnificationXref
db: Entrez Gene
id: 3576

9525868
type: PublicationXref
db: PubMed
title: A single BIR domain of XIAP sufficient for inhibiting caspases
id: 9525868

CASP7_inactive
type: Protein
entity reference: CASP7

http://www.ncbi.nlm.nih.gov/#355
type: UnificationXref
db: Entrez Gene
id: 355

MAP3K7
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6885
organism: Homo sapiens

18408758
type: PublicationXref
db: PubMed
title: Regulation of IKKbeta by miR-199a affects NF-kappaB activity in ovarian cancer cells
id: 18408758

http://www.ncbi.nlm.nih.gov/#356
type: UnificationXref
db: Entrez Gene
id: 356

TAU:F.000011
type: UnificationXref
db: Spike DB
id: TAU:F-000011

TAU:F.000012
type: UnificationXref
db: Spike DB
id: TAU:F-000012

BIRC2_inactive
type: Protein
entity reference: BIRC2

TAU:F.000015
type: UnificationXref
db: Spike DB
id: TAU:F-000015

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.CXCL1.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.CXCL1
xref: 12101257
data source: Spike
controller: NFkB.complex

CASP8
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#841
organism: Homo sapiens

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.CSF3.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.CSF3
xref: 11995880
xref: 10343541
data source: Spike
controller: NFkB.complex

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.IFNB1.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.IFNB1
xref: 10215868
data source: Spike
controller: NFkB.complex

Collagen-IV.family_inactive
type: Protein

http://www.ncbi.nlm.nih.gov/#3586
type: UnificationXref
db: Entrez Gene
id: 3586

CFLAR
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8837
organism: Homo sapiens

PTGS2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5743
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#6885
type: UnificationXref
db: Entrez Gene
id: 6885

IKBKB
type: Protein
entity reference: IKBKB

http://www.ncbi.nlm.nih.gov/#4616
type: UnificationXref
db: Entrez Gene
id: 4616

18282612
type: PublicationXref
db: PubMed
title: Innate immunity meets with cellular stress at the IKK complex: regulation of the IKK complex by HSP70 and HSP90
id: 18282612

IKK.complex
type: Complex
data source: Spike
name: IKK complex
component: IKBKB
component: CHUK
component: IKBKG

http://www.ncbi.nlm.nih.gov/#567
type: UnificationXref
db: Entrez Gene
id: 567

7758105
type: PublicationXref
db: PubMed
title: The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation
id: 7758105

CXCL2_DNA
type: DnaRegion
entity reference: CXCL2

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.CXCL2.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.CXCL2
xref: 8576166
data source: Spike
controller: NFkB.complex

NFKBIE
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4794
organism: Homo sapiens

Translation
type: MolecularInteraction
participant: CCL3_RNA
participant: CCL3

17145710
type: PublicationXref
db: PubMed
title: IntAct--open source resource for molecular interaction data
id: 17145710

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.CD83.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.CD83
xref: 12857898
data source: Spike
controller: NFkB.complex

20564213
type: PublicationXref
db: PubMed
title: Transcriptional suppression of mir-29b-1/mir-29a promoter by c-Myc, hedgehog, and NF-kappaB
id: 20564213

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.CSF2.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.CSF2
xref: 11121152
data source: Spike
controller: NFkB.complex

FAS
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#355
organism: Homo sapiens

LIN28A_DNA
type: DnaRegion
entity reference: LIN28A

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...INHIBITS.MIR29A.
type: TemplateReactionRegulation
control type: INHIBITION
controlled: Transcription.Regulation.I.NFkB.MIR29A
xref: 20564213
data source: Spike
controller: NFkB.complex

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.FAS.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.FAS
xref: 12761580
data source: Spike
controller: NFkB.complex

9733516
type: PublicationXref
db: PubMed
title: NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
id: 9733516

CXCL1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2919
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#3553
type: UnificationXref
db: Entrez Gene
id: 3553

http://www.ncbi.nlm.nih.gov/#330
type: UnificationXref
db: Entrez Gene
id: 330

http://www.ncbi.nlm.nih.gov/#4609
type: UnificationXref
db: Entrez Gene
id: 4609

http://www.ncbi.nlm.nih.gov/#3551
type: UnificationXref
db: Entrez Gene
id: 3551

http://www.ncbi.nlm.nih.gov/#331
type: UnificationXref
db: Entrez Gene
id: 331

10625696
type: PublicationXref
db: PubMed
title: BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites
id: 10625696

CHUK_inactive
type: Protein
entity reference: CHUK

CSF3_DNA
type: DnaRegion
entity reference: CSF3

http://www.ncbi.nlm.nih.gov/#329
type: UnificationXref
db: Entrez Gene
id: 329

.STAT3.PROMOTES.EGR1.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.STAT3.EGR1
xref: 17129668
data source: Spike
controller: STAT3

11295116
type: PublicationXref
db: PubMed
title: Induction of RANTES chemokine expression in human astrocytic cells is dependent upon activation of NF-kappaB transcription factor
id: 11295116

CCL3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6348
organism: Homo sapiens

CXCL2_RNA
type: RnaRegion
entity reference: CXCL2

NOS2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4843
organism: Homo sapiens

Translation
type: MolecularInteraction
participant: BIRC2_inactive
participant: BIRC2_RNA

http://www.ncbi.nlm.nih.gov/#5179
type: UnificationXref
db: Entrez Gene
id: 5179

VCAM1_DNA
type: DnaRegion
entity reference: VCAM1

CASP9
type: Protein
entity reference: CASP9

IL1B
type: Protein
entity reference: IL1B

IL15
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3600
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#3569
type: UnificationXref
db: Entrez Gene
id: 3569

.CYLD.INHIBITS.IKBKG.
type: Catalysis
controlled: Deubiqitination.I.CYLD.IKBKG
control type: INHIBITION
data source: Spike
controller: CYLD
xref: 12917691
xref: 20932475

8704212
type: PublicationXref
db: PubMed
title: Interleukin-10 gene expression in adult T-cell leukemia
id: 8704212

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...INHIBITS.TNF.
type: TemplateReactionRegulation
control type: INHIBITION
controlled: Transcription.Regulation.I.NFkB.TNF
xref: 9742085
data source: Spike
controller: NFkB.complex

1715367
type: PublicationXref
db: PubMed
title: Enhancers and transcription factors controlling the inducibility of the tumor necrosis factor-alpha promoter in primary macrophages
id: 1715367

CSF3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1440
organism: Homo sapiens

ISG15_DNA
type: DnaRegion
entity reference: ISG15

20711193
type: PublicationXref
db: PubMed
title: MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation
id: 20711193

http://www.ncbi.nlm.nih.gov/#5971
type: UnificationXref
db: Entrez Gene
id: 5971

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.NFKBIA.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.NFKBIA
xref: 7937093
data source: Spike
controller: NFkB.complex

http://www.ncbi.nlm.nih.gov/#5970
type: UnificationXref
db: Entrez Gene
id: 5970

NKRF
type: Protein
entity reference: NKRF

NFKB1_RNA
type: RnaRegion
entity reference: NFKB1

Translation
type: MolecularInteraction
participant: CD48_RNA
participant: CD48

11559530
type: PublicationXref
db: PubMed
title: APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis
id: 11559530

mir16 fam.family
type: Protein
data source: Spike
xref: WEB:0002180

http://www.ncbi.nlm.nih.gov/#79727
type: UnificationXref
db: Entrez Gene
id: 79727

BCL2_DNA
type: DnaRegion
entity reference: BCL2

12162804
type: PublicationXref
db: PubMed
title: Regulation of the gadd45beta promoter by NF-kappaB
id: 12162804

.MAP3K7.PROMOTES.IKBKG.
type: Catalysis
controlled: Phosphorylation.P.MAP3K7.IKBKG
control type: ACTIVATION
data source: Spike
controller: MAP3K7
xref: 16301747

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.BCL2A1.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.BCL2A1
xref: 10049353
data source: Spike
controller: NFkB.complex

20301198
type: PublicationXref
db: PubMed
title: Protein-protein interactions involving IKKgamma (NEMO) that promote the activation of NF-kappaB
id: 20301198

IRF1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3659
organism: Homo sapiens

PARK2
type: Protein
entity reference: PARK2

ERK.family
type: Protein
data source: Spike
xref: TAU:F.000011

BIRC3
type: Protein
entity reference: BIRC3

TRADD_inactive
type: Protein
entity reference: TRADD

CK2.complex
type: Complex
data source: Spike
name: Caseine Kinase 2

http://www.ncbi.nlm.nih.gov/#1540
type: UnificationXref
db: Entrez Gene
id: 1540

12167698
type: PublicationXref
db: PubMed
title: A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells
id: 12167698

.TNFRSF1A.PROMOTES.TRADD.
type: Catalysis
controlled: Physical.Interaction.P.TNFRSF1A.TRADD
control type: ACTIVATION
data source: Spike
controller: TNFRSF1A
xref: 7758105
xref: 8565075

Translation
type: MolecularInteraction
participant: FASLG
participant: FASLG_RNA

MMP14
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4323
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#5966
type: UnificationXref
db: Entrez Gene
id: 5966

RELB
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5971
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#596
type: UnificationXref
db: Entrez Gene
id: 596

CSF3_RNA
type: RnaRegion
entity reference: CSF3

http://www.ncbi.nlm.nih.gov/#597
type: UnificationXref
db: Entrez Gene
id: 597

http://www.ncbi.nlm.nih.gov/#598
type: UnificationXref
db: Entrez Gene
id: 598

Spike
type: Provenance

2183031
type: PublicationXref
db: PubMed
title: Activation of interleukin-6 gene expression through the NF-kappa B transcription factor
id: 2183031

AKT1_inactive
type: Protein
entity reference: AKT1

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.TNF.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.TNF
xref: 7608567
xref: 1715367
xref: 1916897
data source: Spike
controller: NFkB.complex

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.BCL2.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.BCL2
xref: 10085086
data source: Spike
controller: NFkB.complex

.MIR223.INHIBITS.CHUK.
type: Catalysis
controlled: mRNA.stability.I.MIR223.CHUK
control type: INHIBITION
data source: Spike
controller: MIR223
xref: 20711193
xref: 21502305

.BAX.PROMOTES.APAF1.
type: Catalysis
controlled: Other.P.BAX.APAF1
control type: ACTIVATION
data source: Spike
controller: BAX
xref: 11709054

10049353
type: PublicationXref
db: PubMed
title: The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis
id: 10049353

TNFAIP3_DNA
type: DnaRegion
entity reference: TNFAIP3

CCL5
type: Protein
entity reference: CCL5

Translation
type: MolecularInteraction
participant: FAS_RNA
participant: FAS_inactive

FADD
type: Protein
entity reference: FADD

NFKBIA_inactive
type: Protein
entity reference: NFKBIA

http://www.ncbi.nlm.nih.gov/#317
type: UnificationXref
db: Entrez Gene
id: 317

FADD
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8772
organism: Homo sapiens

NFkB_sub_II.family
type: Protein
data source: Spike
xref: TAU:F.000005
member physical entity: RELA
member physical entity: RELB
member physical entity: REL

IER3_RNA
type: RnaRegion
entity reference: IER3

http://www.ncbi.nlm.nih.gov/#5743
type: UnificationXref
db: Entrez Gene
id: 5743

TRAF2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7186
organism: Homo sapiens

11914015
type: PublicationXref
db: PubMed
title: Up-regulation of MMP-2 and MMP-9 leads to degradation of type IV collagen during skeletal muscle reperfusion injury; protection by the MMP inhibitor, doxycycline
id: 11914015

9786883
type: PublicationXref
db: PubMed
title: Downstream activation of a TATA-less promoter by Oct-2, Bob1, and NF-kappaB directs expression of the homing receptor BLR1 to mature B cells
id: 9786883

PARK2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5071
organism: Homo sapiens

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...INHIBITS.BNIP3.
type: Catalysis
controlled: Indirect.I.NFkB.BNIP3
control type: INHIBITION
data source: Spike
controller: NFkB.complex
xref: 19136941

IKK.complex_inactive
type: Protein

16301747
type: PublicationXref
db: PubMed
title: PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1
id: 16301747

B2M
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#567
organism: Homo sapiens

CD48
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#962
organism: Homo sapiens

EGR1
type: Protein
entity reference: EGR1

CXCL10
type: Protein
entity reference: CXCL10

NOS2_DNA
type: DnaRegion
entity reference: NOS2

Translation
type: MolecularInteraction
participant: MMP9_RNA
participant: MMP9

http://www.ncbi.nlm.nih.gov/#5730
type: UnificationXref
db: Entrez Gene
id: 5730

BCL2A1_RNA
type: RnaRegion
entity reference: BCL2A1

IL10_DNA
type: DnaRegion
entity reference: IL10

19650740
type: PublicationXref
db: PubMed
title: Induction of microRNA-155 during Helicobacter pylori infection and its negative regulatory role in the inflammatory response
id: 19650740

AKT1
type: Protein
entity reference: AKT1

http://www.ncbi.nlm.nih.gov/#581
type: UnificationXref
db: Entrez Gene
id: 581

BIRC3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#330
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#5728
type: UnificationXref
db: Entrez Gene
id: 5728

MYC
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4609
organism: Homo sapiens

RELA
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5970
organism: Homo sapiens

BIRC3_RNA
type: RnaRegion
entity reference: BIRC3

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.CCL20.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.CCL20
xref: 12414801
data source: Spike
controller: NFkB.complex

TNFRSF10B_inactive
type: Protein
entity reference: TNFRSF10B

.TNFRSF1A.PROMOTES.RIPK1.
type: Catalysis
controlled: Physical.Interaction.P.TNFRSF1A.RIPK1
control type: ACTIVATION
data source: Spike
controller: TNFRSF1A
xref: 8612133

9414121
type: PublicationXref
db: PubMed
title: Involvement of NF-kappaB in the regulation of cyclooxygenase-2 protein expression in LPS-stimulated J774 macrophages
id: 9414121

CXCL2
type: Protein
entity reference: CXCL2

APAF1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#317
organism: Homo sapiens

IL8
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3576
organism: Homo sapiens

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.IER3.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.IER3
xref: 9703517
data source: Spike
controller: NFkB.complex

.Complex.CK2....INHIBITS.NFKBIA.
type: Catalysis
controlled: Phosphorylation.I.CK2.NFKBIA
control type: INHIBITION
data source: Spike
controller: CK2.complex
xref: 15818404

10644043
type: PublicationXref
db: PubMed
title: Suppression of lipopolysaccharide-induced nuclear factor-kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages
id: 10644043

18193389
type: PublicationXref
db: PubMed
title: Interaction of aging-associated signaling cascades: inhibition of NF-kappaB signaling by longevity factors FoxOs and SIRT1
id: 18193389

.Family.mir.9....INHIBITS.NFKB1.
type: Catalysis
controlled: mRNA.stability.I.mir.9.NFKB1
control type: INHIBITION
data source: Spike
controller: mir-9.family
xref: 21502305

http://www.ncbi.nlm.nih.gov/#8870
type: UnificationXref
db: Entrez Gene
id: 8870

MIR21
type: Protein
entity reference: MIR21

Translation
type: MolecularInteraction
participant: ICAM1
participant: ICAM1_RNA

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.MMP14.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.MMP14
xref: 11112697
data source: Spike
controller: NFkB.complex

MIR181B1_DNA
type: DnaRegion
entity reference: MIR181B1

DUSP1_DNA
type: DnaRegion
entity reference: DUSP1

16497931
type: PublicationXref
db: PubMed
title: Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli
id: 16497931

NFKBIB
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4793
organism: Homo sapiens

TP53
type: Protein
entity reference: TP53

IL1B
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3553
organism: Homo sapiens

12042762
type: PublicationXref
db: PubMed
title: IAP proteins: blocking the road to death's door
id: 12042762

PTGS2
type: Protein
entity reference: PTGS2

.MIR181B1.INHIBITS.CYLD.
type: Catalysis
controlled: mRNA.stability.I.MIR181B1.CYLD
control type: INHIBITION
data source: Spike
controller: MIR181B1
xref: 20797623
xref: 21502305

CCL3_RNA
type: RnaRegion
entity reference: CCL3

NFkB.complex_DNA
type: DnaRegion

IFNB1_RNA
type: RnaRegion
entity reference: IFNB1

BIRC3_DNA
type: DnaRegion
entity reference: BIRC3

Translation
type: MolecularInteraction
participant: MIR181B1_RNA
participant: MIR181B1

CXCL1_RNA
type: RnaRegion
entity reference: CXCL1

7907090
type: PublicationXref
db: PubMed
title: - and tumor necrosis factor alpha-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone. Functional analysis of the human icam1
id: 7907090

MAP3K7
type: Protein
entity reference: MAP3K7

.MMP9.INHIBITS.Family.Collagen.IV....
type: Catalysis
controlled: Other.I.MMP9.Collagen.IV
control type: INHIBITION
data source: Spike
controller: MMP9
xref: 11914015

Translation
type: MolecularInteraction
participant: NFKBIA_RNA
participant: NFKBIA_inactive

PTEN_DNA
type: DnaRegion
entity reference: PTEN

MIR29B1_DNA
type: DnaRegion
entity reference: MIR29B1

9765224
type: PublicationXref
db: PubMed
title: Pro-caspase-3 is a major physiologic target of caspase-8
id: 9765224

CD48_RNA
type: RnaRegion
entity reference: CD48

NFkB.complex
type: Complex
data source: Spike
name: Nuclear factor kappa-B
component: NFkB_sub_I.family
component: NFkB_sub_II.family

MIR155
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#406947
organism: Homo sapiens

IL10
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3586
organism: Homo sapiens

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.IFIT1.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.IFIT1
xref: 12354379
data source: Spike
controller: NFkB.complex

10501190
type: PublicationXref
db: PubMed
title: Bradykinin induces interleukin-6 expression in astrocytes through activation of nuclear factor-kappaB
id: 10501190

IL10
type: Protein
entity reference: IL10

.FAS.PROMOTES.FADD.
type: Catalysis
controlled: Physical.Interaction.P.FAS.FADD
control type: ACTIVATION
data source: Spike
controller: FAS
xref: 8967952
xref: 7536190
xref: 7538907

CYLD
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1540
organism: Homo sapiens

9111042
type: PublicationXref
db: PubMed
title: A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members
id: 9111042

PTGDS_RNA
type: RnaRegion
entity reference: PTGDS

XIAP_inactive
type: Protein
entity reference: XIAP

9660938
type: PublicationXref
db: PubMed
title: DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1
id: 9660938

MIR21
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#406991
organism: Homo sapiens

TLR2
type: Protein
entity reference: TLR2

FAS_RNA
type: RnaRegion
entity reference: FAS

MADCAM1_RNA
type: RnaRegion
entity reference: MADCAM1

12384981
type: PublicationXref
db: PubMed
title: Regulation of life and death by the zinc finger transcription factor Egr-1
id: 12384981

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.LIN28A.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.LIN28A
xref: 19878981
data source: Spike
controller: NFkB.complex

.TNF.PROMOTES.TNFRSF1A.
type: Catalysis
controlled: Physical.Interaction.P.TNF.TNFRSF1A
control type: ACTIVATION
data source: Spike
controller: TNF
xref: 10634209
xref: 19442713
xref: 2158863

9788276
type: PublicationXref
db: PubMed
title: Regulation of human IP-10 gene expression in astrocytoma cells by inflammatory cytokines
id: 9788276

APAF1_DNA
type: DnaRegion
entity reference: APAF1

IL1B_DNA
type: DnaRegion
entity reference: IL1B

.MMP2.INHIBITS.Family.Collagen.IV....
type: Catalysis
controlled: Other.I.MMP2.Collagen.IV
control type: INHIBITION
data source: Spike
controller: MMP2
xref: 11914015

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.CD48.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.CD48
xref: 9786883
data source: Spike
controller: NFkB.complex

PENK_DNA
type: DnaRegion
entity reference: PENK

18485876
type: PublicationXref
db: PubMed
title: TNF-alpha induces two distinct caspase-8 activation pathways
id: 18485876

9390557
type: PublicationXref
db: PubMed
title: Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
id: 9390557

15184909
type: PublicationXref
db: PubMed
title: Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas
id: 15184909

MIR181B1
type: Protein
entity reference: MIR181B1

Translation
type: MolecularInteraction
participant: PTEN_inactive
participant: PTEN_RNA

CSF2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1437
organism: Homo sapiens

9742125
type: PublicationXref
db: PubMed
title: Mutagenesis of the BH3 domain of BAX identifies residues critical for dimerization and killing
id: 9742125

http://www.ncbi.nlm.nih.gov/#8837
type: UnificationXref
db: Entrez Gene
id: 8837

IER3_DNA
type: DnaRegion
entity reference: IER3

.TRADD.PROMOTES.FADD.
type: Catalysis
controlled: Physical.Interaction.P.TRADD.FADD
control type: ACTIVATION
data source: Spike
controller: TRADD
xref: 8565075

Translation
type: MolecularInteraction
participant: MIR29B1_RNA
participant: MIR29B1

7834749
type: PublicationXref
db: PubMed
title: Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
id: 7834749

.MIR155.INHIBITS.RIPK1.
type: Catalysis
controlled: mRNA.stability.I.MIR155.RIPK1
control type: INHIBITION
data source: Spike
controller: MIR155
xref: 21502305
xref: 17911593

.RIPK1.PROMOTES.FADD.
type: Catalysis
controlled: Physical.Interaction.P.RIPK1.FADD
control type: ACTIVATION
data source: Spike
controller: RIPK1
xref: 11002422

BAX
type: Protein
entity reference: BAX

21502305
type: PublicationXref
db: PubMed
title: MicroRNAs in NF-{kappa}B signaling
id: 21502305

GADD45B
type: Protein
entity reference: GADD45B

IL10_RNA
type: RnaRegion
entity reference: IL10

Translation
type: MolecularInteraction
participant: CD83_RNA
participant: CD83

TAU:F.000004
type: UnificationXref
db: Spike DB
id: TAU:F-000004

TAU:F.000005
type: UnificationXref
db: Spike DB
id: TAU:F-000005

TNFRSF10B
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8795
organism: Homo sapiens

11002422
type: PublicationXref
db: PubMed
title: Activation of death-inducing signaling complex (DISC) by pro-apoptotic C-terminal fragment of RIP
id: 11002422

LIN28A_RNA
type: RnaRegion
entity reference: LIN28A

http://www.ncbi.nlm.nih.gov/#4323
type: UnificationXref
db: Entrez Gene
id: 4323

BIRC2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#329
organism: Homo sapiens

.CASP8.PROMOTES.CASP3.
type: Catalysis
controlled: Proteolytic.Processing.P.CASP8.CASP3
control type: ACTIVATION
data source: Spike
controller: CASP8
xref: 9765224
xref: 11437602

17911593
type: PublicationXref
db: PubMed
title: Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock
id: 17911593

15538968
type: PublicationXref
db: PubMed
title: Following a TRAIL: update on a ligand and its five receptors
id: 15538968

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.TLR2.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.TLR2
xref: 11254708
data source: Spike
controller: NFkB.complex

Translation
type: MolecularInteraction
participant: CXCL10_RNA
participant: CXCL10

http://www.ebi.ac.uk/chebi/#16480
type: UnificationXref
db: ChEBI
id: 16480

11600537
type: PublicationXref
db: PubMed
title: IL-1beta induction of RANTES (regulated upon activation, normal T cell expressed and secreted) chemokine gene expression in endometriotic stromal cells depends on a nuclear factor-kappaB site in the proximal promoter
id: 11600537

14668806
type: PublicationXref
db: PubMed
title: Regulation of JAK-STAT signalling in the immune system
id: 14668806

MIR181B1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#406955
organism: Homo sapiens

9545235
type: PublicationXref
db: PubMed
title: IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
id: 9545235

8967952
type: PublicationXref
db: PubMed
title: NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain
id: 8967952

CD83
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#9308
organism: Homo sapiens

CXCL10
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3627
organism: Homo sapiens

VCAM1
type: Protein
entity reference: VCAM1

ICAM1
type: Protein
entity reference: ICAM1

ICAM1_DNA
type: DnaRegion
entity reference: ICAM1

CCL3
type: Protein
entity reference: CCL3

MMP14_inactive
type: Protein
entity reference: MMP14

LRDD
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#55367
organism: Homo sapiens

Translation
type: MolecularInteraction
participant: ISG15
participant: ISG15_RNA

IRF1
type: Protein
entity reference: IRF1

http://www.ncbi.nlm.nih.gov/#7128
type: UnificationXref
db: Entrez Gene
id: 7128

WEB:0002180
type: UnificationXref
db: Spike DB
id: WEB:0002180

.BIRC2.INHIBITS.TRAF2.
type: Catalysis
controlled: Ubiquitination.I.BIRC2.TRAF2
control type: INHIBITION
data source: Spike
controller: BIRC2
xref: 11907583

MMP9
type: Protein
entity reference: MMP9

.TP53.PROMOTES.APAF1.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.TP53.APAF1
xref: 11559530
xref: 11389439
xref: 11423996
data source: Spike
controller: TP53

SOCS1_DNA
type: DnaRegion
entity reference: SOCS1

11389439
type: PublicationXref
db: PubMed
title: Apaf-1 is a transcriptional target for E2F and p53
id: 11389439

.CCL2.PROMOTES.MMP14.
type: Catalysis
controlled: Indirect.P.CCL2.MMP14
control type: ACTIVATION
data source: Spike
controller: CCL2
xref: 15516694

BCL2A1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#597
organism: Homo sapiens

TRAF2_RNA
type: RnaRegion
entity reference: TRAF2

Translation
type: MolecularInteraction
participant: CCL2
participant: CCL2_RNA

TRAF6
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7189
organism: Homo sapiens

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.CCL3.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.CCL3
xref: 8355682
data source: Spike
controller: NFkB.complex

http://www.ncbi.nlm.nih.gov/#7124
type: UnificationXref
db: Entrez Gene
id: 7124

Translation
type: MolecularInteraction
participant: SOCS1
participant: SOCS1_RNA

11106668
type: PublicationXref
db: PubMed
title: c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment
id: 11106668

IL12B
type: Protein
entity reference: IL12B

12540607
type: PublicationXref
db: PubMed
title: Molecular regulation of monocyte chemoattractant protein-1 expression in pancreatic beta-cells
id: 12540607

BCL2A1_DNA
type: DnaRegion
entity reference: BCL2A1

WEB:0002173
type: UnificationXref
db: Spike DB
id: WEB:0002173

9703517
type: PublicationXref
db: PubMed
title: IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival
id: 9703517

MIR29B1_RNA
type: RnaRegion
entity reference: MIR29B1

8565075
type: PublicationXref
db: PubMed
title: TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
id: 8565075

9759866
type: PublicationXref
db: PubMed
title: Identification of two NF-kappa B sites in mouse CD95 ligand (Fas ligand) promoter: functional analysis in T cell hybridoma
id: 9759866

BNIP3_inactive
type: Protein
entity reference: BNIP3

2158863
type: PublicationXref
db: PubMed
title: Molecular cloning and expression of a receptor for human tumor necrosis factor
id: 2158863

Translation
type: MolecularInteraction
participant: CSF2
participant: CSF2_RNA

MIR181B1_RNA
type: RnaRegion
entity reference: MIR181B1

9317150
type: PublicationXref
db: PubMed
title: TNF initiates E-selectin transcription in human endothelial cells through parallel TRAF-NF-kappa B and TRAF-RAC/CDC42-JNK-c-Jun/ATF2 pathways
id: 9317150

IFIT1_DNA
type: DnaRegion
entity reference: IFIT1

.CASP3.INHIBITS.BIRC2.
type: Catalysis
controlled: Proteolytic.Processing.I.CASP3.BIRC2
control type: INHIBITION
data source: Spike
controller: CASP3
xref: 11106668

MIR29B1
type: Protein
entity reference: MIR29B1

http://www.ncbi.nlm.nih.gov/#4318
type: UnificationXref
db: Entrez Gene
id: 4318

IkB.family_inactive
type: Protein

9488720
type: PublicationXref
db: PubMed
title: Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex
id: 9488720

IL15_DNA
type: DnaRegion
entity reference: IL15

http://www.ncbi.nlm.nih.gov/#4313
type: UnificationXref
db: Entrez Gene
id: 4313

PTEN_RNA
type: RnaRegion
entity reference: PTEN

GSTP1_RNA
type: RnaRegion
entity reference: GSTP1

9873041
type: PublicationXref
db: PubMed
title: Regulation of Fas-Ligand Expression during Activation-induced Cell Death in T Lymphocytes via Nuclear Factor B
id: 9873041

8681376
type: PublicationXref
db: PubMed
title: Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
id: 8681376

GSTP1_DNA
type: DnaRegion
entity reference: GSTP1

Translation
type: MolecularInteraction
participant: MADCAM1_RNA
participant: MADCAM1

MIR15A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#406948
organism: Homo sapiens

CSF2_DNA
type: DnaRegion
entity reference: CSF2

12761580
type: PublicationXref
db: PubMed
title: TNF combined with IFN-alpha accelerates NF-kappaB-mediated apoptosis through enhancement of Fas expression in colon cancer cells
id: 12761580

LIN28A
type: Protein
entity reference: LIN28A

.Family.mir16.fam....INHIBITS.CHUK.
type: Catalysis
controlled: mRNA.stability.I.mir16.fam.CHUK
control type: INHIBITION
data source: Spike
controller: mir16 fam.family
xref: 20711193
xref: 21502305

CCL3_DNA
type: DnaRegion
entity reference: CCL3

TRAF6_inactive
type: Protein
entity reference: TRAF6

IRF4
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3662
organism: Homo sapiens

EGR1_DNA
type: DnaRegion
entity reference: EGR1

MMP14
type: Protein
entity reference: MMP14

NFKBIA
type: Protein
entity reference: NFKBIA

http://www.ncbi.nlm.nih.gov/#407021
type: UnificationXref
db: Entrez Gene
id: 407021

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.CCL2.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.CCL2
xref: 15081318
xref: 11343293
xref: 12540607
data source: Spike
controller: NFkB.complex

CXCL10_DNA
type: DnaRegion
entity reference: CXCL10

http://www.ncbi.nlm.nih.gov/#7132
type: UnificationXref
db: Entrez Gene
id: 7132

11907583
type: PublicationXref
db: PubMed
title: TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
id: 11907583

IKBKE
type: Protein
entity reference: IKBKE

http://www.ncbi.nlm.nih.gov/#407027
type: UnificationXref
db: Entrez Gene
id: 407027

http://www.ncbi.nlm.nih.gov/#407024
type: UnificationXref
db: Entrez Gene
id: 407024

9988718
type: PublicationXref
db: PubMed
title: Role of interferon regulatory factor-1 and mitogen-activated protein kinase pathways in the induction of nitric oxide synthase-2 in retinal pigmented epithelial cells
id: 9988718

mir-199a.family
type: Protein
data source: Spike
xref: TAU:F.329926

.FASLG.PROMOTES.FAS.
type: Catalysis
controlled: Physical.Interaction.P.FASLG.FAS
control type: ACTIVATION
data source: Spike
controller: FASLG
xref: 9228058
xref: 9126929

CEN:F.329896
type: UnificationXref
db: Spike DB
id: CEN:F-329896

SIRT1
type: Protein
entity reference: SIRT1

APAF1_inactive
type: Protein
entity reference: APAF1

IL12B_RNA
type: RnaRegion
entity reference: IL12B

TNFRSF1A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7132
organism: Homo sapiens

MIR15A
type: Protein
entity reference: MIR15A

TAU:F.329926
type: UnificationXref
db: Spike DB
id: TAU:F-329926

Translation
type: MolecularInteraction
participant: BAX_RNA
participant: BAX_inactive

TAU:F.329924
type: UnificationXref
db: Spike DB
id: TAU:F-329924

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.BIRC3.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.BIRC3
xref: 10751398
data source: Spike
controller: NFkB.complex

ICAM1_RNA
type: RnaRegion
entity reference: ICAM1

CFLAR
type: Protein
entity reference: CFLAR

.NO.INHIBITS.NFKB1.
type: Catalysis
controlled: Other.I.NO.NFKB1
control type: INHIBITION
data source: Spike
controller: NO
xref: 18495079

.MIR155.INHIBITS.FADD.
type: Catalysis
controlled: mRNA.stability.I.MIR155.FADD
control type: INHIBITION
data source: Spike
controller: MIR155
xref: 19650740
xref: 17911593
xref: 21502305

CD83_DNA
type: DnaRegion
entity reference: CD83

BCL2
type: Protein
entity reference: BCL2

TNFRSF1A
type: Protein
entity reference: TNFRSF1A

NFkB.complex_RNA
type: RnaRegion

PhysicalInteraction [CYLD -- IKBKG ]
type: MolecularInteraction
participant: CYLD
participant: IKBKG
xref: 12917691

Translation
type: MolecularInteraction
participant: PENK
participant: PENK_RNA

LRDD
type: Protein
entity reference: LRDD

BCL2A1
type: Protein
entity reference: BCL2A1

IER3
type: Protein
entity reference: IER3

.MIR21.INHIBITS.PTEN.
type: Catalysis
controlled: N/A.I.MIR21.PTEN
control type: INHIBITION
data source: Spike
controller: MIR21
xref: 19906824
xref: 17681183

EGR1_RNA
type: RnaRegion
entity reference: EGR1

BAX_inactive
type: Protein
entity reference: BAX

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.GSTP1.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.GSTP1
xref: 8546677
data source: Spike
controller: NFkB.complex

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.BIRC2.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.BIRC2
xref: 9733516
data source: Spike
controller: NFkB.complex

ELK:F.329909
type: UnificationXref
db: Spike DB
id: ELK:F-329909

MIR301A
type: Protein
entity reference: MIR301A

.Family.ERK....PROMOTES.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL..(NFKB1).
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.ERK.NFkB
xref: 17138645
data source: Spike
controller: ERK.family

CASP9
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#842
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#55367
type: UnificationXref
db: Entrez Gene
id: 55367

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.CCL5.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.CCL5
xref: 11295116
xref: 10926836
xref: 11600537
data source: Spike
controller: NFkB.complex

BAX_DNA
type: DnaRegion
entity reference: BAX

IL18
type: Protein
entity reference: IL18

15516694
type: PublicationXref
db: PubMed
title: Membrane type 1-matrix metalloproteinase is regulated by chemokines monocyte-chemoattractant protein-1/ccl2 and interleukin-8/CXCL8 in endothelial cells during angiogenesis
id: 15516694

12529332
type: PublicationXref
db: PubMed
title: Ceramide-induced and age-associated increase in macrophage COX-2 expression is mediated through up-regulation of NF-kappa B activity
id: 12529332

.Complex.NFkB..Family.NFkB sub I..NFKB1,.NFKB2.,.Family.NFkB sub II..RELA,.RELB,.REL...PROMOTES.PTGS2.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.NFkB.PTGS2
xref: 9414121
xref: 12860389
xref: 12529332
data source: Spike
controller: NFkB.complex

http://www.ncbi.nlm.nih.gov/#406955
type: UnificationXref
db: Entrez Gene
id: 406955

TLR2_RNA
type: RnaRegion
entity reference: TLR2

http://www.ncbi.nlm.nih.gov/#1958
type: UnificationXref
db: Entrez Gene
id: 1958

MMP9
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4318
organism: Homo sapiens

8413223
type: PublicationXref
db: PubMed
title: Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop
id: 8413223

11359904
type: PublicationXref
db: PubMed
title: NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling
id: 11359904

http://www.ncbi.nlm.nih.gov/#1147
type: UnificationXref
db: Entrez Gene
id: 1147

FAS
type: Protein
entity reference: FAS

MIR21_inactive
type: Protein
entity reference: MIR21

TNFAIP3
type: Protein
entity reference: TNFAIP3

http://www.ncbi.nlm.nih.gov/#406947
type: UnificationXref
db: Entrez Gene
id: 406947

FASLG
type: Protein
entity reference: FASLG

12917691
type: PublicationXref
db: PubMed
title: The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination
id: 12917691

http://www.ncbi.nlm.nih.gov/#406948
type: UnificationXref
db: Entrez Gene
id: 406948

XIAP
type: Protein
entity reference: XIAP

IRF4_DNA
type: DnaRegion
entity reference: IRF4

B2M_RNA
type: RnaRegion
entity reference: B2M

10770796
type: PublicationXref
db: PubMed
title: Rel induces interferon regulatory factor 4 (IRF-4) expression in lymphocytes: modulation of interferon-regulated gene expression by rel/nuclear factor kappaB
id: 10770796