Automatically obtained from Entrez Gene on 23-05-11PONTINTIP49ATIP49Pontin52ECP54INO80HNMP238TIH1RVB1Automatically obtained from Entrez Gene on 23-05-11EMC19OCP-IITCEB1LSKP1AOCP2p19AMGC34403Automatically obtained from Entrez Gene on 23-05-11BM029SMARCF1P270BAF250aBAF250C1orf4B120Automatically obtained from Entrez Gene on 23-05-11MGC129811BCL-BMGC129810BooDivaAutomatically obtained from Entrez Gene on 23-05-11OSRCRBp105-RbpRbpp110Automatically obtained from Entrez Gene on 23-05-11TIGARAutomatically obtained from Entrez Gene on 23-05-11DKFZp781P2312Epl1Automatically obtained from Entrez Gene on 23-05-11MGC149835MGC149834Automatically obtained from Entrez Gene on 23-05-11PP2APTPAPR53MGC2184Automatically obtained from Entrez Gene on 23-05-11B56AMGC131915PR61AAutomatically obtained from Entrez Gene on 23-05-11Bif-1KIAA0491dJ612B15.2Automatically obtained from Entrez Gene on 23-05-11RGC32MGC87338bA157L14.2RGC-32KIAA0564Automatically obtained from Entrez Gene on 23-05-11NURF55RBAP48Automatically obtained from Entrez Gene on 23-05-11STAF40TR-APPAF400FLJ10671Tra1PAF350/400Automatically obtained from Entrez Gene on 23-05-11E2F-2Automatically obtained from Entrez Gene on 23-05-11YL-1YL1CFL1Swc2TCFL1Automatically obtained from Entrez Gene on 23-05-11MGC104598DKFZp686C18211E2F-3KIAA0075Automatically obtained from Entrez Gene on 23-05-11UV-DDB2FLJ34321DDBBAutomatically obtained from Entrez Gene on 23-05-11FLJ11543DNMTAP1KIAA1425EAF2SWC4DKFZp686L09142MEAF2DNMAP1Automatically obtained from Entrez Gene on 23-05-11RBBP3RBAP1RBP3E2F-1Automatically obtained from Entrez Gene on 23-05-11FLJ42994JFY1PUMAAutomatically obtained from Entrez Gene on 23-05-11TIP60TIPcPLA2PLIPHTATIP1ESA1HTATIPAutomatically obtained from Entrez Gene on 23-05-11BAF200FLJ30619DKFZp779P0222p200DKFZp686G052KIAA1557Automatically obtained from Entrez Gene on 23-05-11PP2CARP-CPP2CalphaPP2AcAutomatically obtained from Entrez Gene on 23-05-11DDIT1GADD45Automatically obtained from Entrez Gene on 23-05-11HIST4H4HIST1H4LHIST1H4KH4FMHIST2H4AHIST2H4BHIST1H4AHIST1H4BH4MHIST1H4EHIST1H4FHIST1H4CHIST1H4DH4/mHIST1H4JHIST1H4HAutomatically obtained from Entrez Gene on 23-05-11MGC33725KIAA1736FLJ20294WDR94DCAF3Automatically obtained from Entrez Gene on 23-05-11HIST1H4LHIST1H4KMGC24116HIST2H4AHIST2H4BHIST1H4AHIST1H4BHIST1H4EHIST1H4FH4/pHIST1H4CHIST1H4DHIST1H4IHIST1H4JHIST1H4HAutomatically obtained from Entrez Gene on 23-05-11G0S30ZNF225AT225ZIF-268NGFI-AKROX-24TIS8Automatically obtained from Entrez Gene on 23-05-11LAZ3BCL6ABCL5ZNF51ZBTB27Automatically obtained from Entrez Gene on 23-05-11KIAA9001D6S113ERNF3NATFSHDKFZp686N0336RING3FLJ31942FSRG1Automatically obtained from Entrez Gene on 23-05-11DKFZp434D229PIDDMGC16925Automatically obtained from Entrez Gene on 23-05-11p150VPS15MGC102700Automatically obtained from Entrez Gene on 23-05-11MGC1481BA554C12.1ROC1RNF75MGC13357FLJ60363Automatically obtained from Entrez Gene on 23-05-11APRNOXAAutomatically obtained from Entrez Gene on 23-05-11TIP49BREPTININO80JRVB2ECP51TIP48TIH2Automatically obtained from Entrez Gene on 23-05-11MGC1671ASE1MGC3669Automatically obtained from Entrez Gene on 23-05-11IL1BCICEP45Automatically obtained from Entrez Gene on 23-05-11MGC8367Automatically obtained from Entrez Gene on 23-05-11CAGH32DKFZP434I225P400TNRC12FLJ45115FLJ42018Automatically obtained from Entrez Gene on 23-05-11BAF53BACTL6Automatically obtained from Entrez Gene on 23-05-11PRKM14CSPB1EXIPp38SAPK2AMxi2CSBP1CSBPp38ALPHACSBP2RKPRKM15Automatically obtained from Entrez Gene on 23-05-11MTDPS8BMTDPS8ADKFZp686M05248MGC42116P53R2MGC102856Automatically obtained from Entrez Gene on 23-05-11miRNA34Amir-34MIRN34AAutomatically obtained from Entrez Gene on 23-05-11miRNA34CMIRN34CAutomatically obtained from Entrez Gene on 23-05-11miRNA34BMIRN34BAutomatically obtained from Entrez Gene on 23-05-11HARAKIRIDP5Automatically obtained from Entrez Gene on 23-05-11RNF83MLN62CART1Automatically obtained from Entrez Gene on 23-05-11HsT16930HRAD51RAD51AHsRad51BRCC5RECAAutomatically obtained from Entrez Gene on 23-05-11MGC5276RFC38Automatically obtained from Entrez Gene on 23-05-11DAPKDKFZp781I035Automatically obtained from Entrez Gene on 23-05-11A1RFC40MGC3665Automatically obtained from Entrez Gene on 23-05-11RFC36MGC1155Automatically obtained from Entrez Gene on 23-05-11A1MGC27291RFC37Automatically obtained from Entrez Gene on 23-05-11B99Automatically obtained from Entrez Gene on 23-05-11MIRN605hsa-mir-605Automatically obtained from Entrez Gene on 23-05-11SCA-1CPP32CPP32BAutomatically obtained from Entrez Gene on 23-05-11PRAD1D11S287EU21B31BCL1Automatically obtained from Entrez Gene on 23-05-11Bcl-2Automatically obtained from Entrez Gene on 23-05-11FLICECAP4FLJ17672Casp-8MACHMCH5MGC78473ALPS2BAutomatically obtained from Entrez Gene on 23-05-11P53AIP1Automatically obtained from Entrez Gene on 23-05-11CASPASE-9cAPAF-3ICE-LAP6APAF3MCH6Automatically obtained from Entrez Gene on 23-05-11FLICE2MCH4ALPS2Automatically obtained from Entrez Gene on 23-05-11H3FAH3/AAutomatically obtained from Entrez Gene on 23-05-11MCH2Automatically obtained from Entrez Gene on 23-05-11MIRN504hsa-mir-504Automatically obtained from Entrez Gene on 23-05-11GLY96IEX1IEX-1LIEX-1PRG1DIF2DIF-2Automatically obtained from Entrez Gene on 23-05-11KIAA0271BCLWBCL-WBCL2-L-2Automatically obtained from Entrez Gene on 23-05-11THC4CYCHCSAutomatically obtained from Entrez Gene on 23-05-11BCLXBCLXSbcl-xLBCL-XL/SBCL2LBcl-Xbcl-xSBCLXLDKFZp781P2092Automatically obtained from Entrez Gene on 23-05-11BCL2L5HBPA1ACC-1ACC-2GRSBFL1Automatically obtained from Entrez Gene on 23-05-11HIST2H3AH3F2H3/MH3H3FNH3FMMGC9629H3.2HIST2H3DAutomatically obtained from Entrez Gene on 23-05-11PB1BAF180MGC156155MGC156156Automatically obtained from Entrez Gene on 23-05-11H4FBdJ221C16.9H4/bAutomatically obtained from Entrez Gene on 23-05-11PRKM10MGC50974JNK3AFLJ33785FLJ12099p54bSAPKJNK3p493F12Automatically obtained from Entrez Gene on 23-05-11H3F1KHIST1H3JH3FKFLJ92264HIST1H3AHIST1H3BHIST1H3CHIST1H3DHIST1H3EH3/kHIST1H3FHIST1H3GHIST1H3IAutomatically obtained from Entrez Gene on 23-05-11HIST1H3AHIST1H3BHIST1H3CHIST1H3DHIST1H3EH3FJHIST1H3FHIST1H3GH3/jHIST1H3HHIST1H3IAutomatically obtained from Entrez Gene on 23-05-11XPEUV-DDB1DDBAXPCEXPE-BFXAP1Automatically obtained from Entrez Gene on 23-05-11H4/aH4FAAutomatically obtained from Entrez Gene on 23-05-11PRKM13p38deltaMGC99536SAPK4Automatically obtained from Entrez Gene on 23-05-11PC3MGC126063MGC126064TIS21Automatically obtained from Entrez Gene on 23-05-11H3/lH3FLAutomatically obtained from Entrez Gene on 23-05-11H3/dH3FDH3.1Automatically obtained from Entrez Gene on 23-05-11BCL2L8BBC2Automatically obtained from Entrez Gene on 23-05-11H3/cH3FCH3.1Automatically obtained from Entrez Gene on 23-05-11p63DHTXVPS38Automatically obtained from Entrez Gene on 23-05-11H3FHH3/hAutomatically obtained from Entrez Gene on 23-05-11HIST1H3JHIST1H3AHIST1H3BHIST1H3CH3/fHIST1H3DHIST1H3EHIST1H3FHIST1H3GHIST1H3HH3.fH3FFAutomatically obtained from Entrez Gene on 23-05-11PRKM11P38BSAPK2Bp38-2p38BetaSAPK2P38BETA2Automatically obtained from Entrez Gene on 23-05-11p54aSAPKp54aJNK2BETAJNK-55JNK2BPRKM9JNK2ALPHAJNK2AJNK2SAPKAutomatically obtained from Entrez Gene on 23-05-11RNF94STAF50GPSTAF50Automatically obtained from Entrez Gene on 23-05-11PRKM7ERK5BMK1ERK4Automatically obtained from Entrez Gene on 23-05-11JNKPRKM8JNK1A2JNK1JNK21B1/2SAPK1Automatically obtained from Entrez Gene on 23-05-11HNPCC4PMS2CLPMSL2Automatically obtained from Entrez Gene on 23-05-11COFSCSBCOFS1CKN2ARMD5RAD26Automatically obtained from Entrez Gene on 23-05-11HIST4H4HIST1H4LHIST1H4KH4F2H4FNHIST2H4BHIST2H4H4HIST1H4AHIST1H4BHIST1H4EHIST1H4FHIST1H4CHIST1H4DH4/nHIST1H4IHIST1H4JFO108HIST1H4HAutomatically obtained from Entrez Gene on 23-05-11HIST4H4HIST1H4KH4FKHIST2H4AHIST2H4BH4.kHIST1H4AHIST1H4BHIST1H4EHIST1H4FHIST1H4CHIST1H4DHIST1H4IHIST1H4JH4/kHIST1H4HAutomatically obtained from Entrez Gene on 23-05-11H4/jH4FJAutomatically obtained from Entrez Gene on 23-05-11PRKM6ERK3DKFZp686F03189HsT17250p97MAPKAutomatically obtained from Entrez Gene on 23-05-11H4/IH4FIAutomatically obtained from Entrez Gene on 23-05-11PRKM4ERK3Erk4p63MAPKAutomatically obtained from Entrez Gene on 23-05-11H4/hH4FHAutomatically obtained from Entrez Gene on 23-05-11H3/oH3/nHIST2H3CHIST2H3DAutomatically obtained from Entrez Gene on 23-05-11HS44KDAPERK1P44MAPKHUMKER1AP44ERK1MGC20180PRKM3Automatically obtained from Entrez Gene on 23-05-11H4/gH4FGdJ221C16.1Automatically obtained from Entrez Gene on 23-05-11BRIGHT6A3-5P250ROSA2KIAA1235ELD/OSA1DAN15BAF250BAutomatically obtained from Entrez Gene on 23-05-11MAPK2p41mapkERK2p38ERKP42MAPKp40p41PRKM2PRKM1ERT1Automatically obtained from Entrez Gene on 23-05-11HIST4H4HIST1H4LHIST1H4KMGC166960H4F2ivdJ160A22.2MGC29783HIST2H4AHIST2H4BH4FEHIST1H4AH4/eHIST1H4BHIST1H4EHIST1H4FHIST1H4CHIST1H4DHIST1H4IHIST1H4HAutomatically obtained from Entrez Gene on 23-05-11H4F2iiiHIST4H4HIST1H4LHIST2H4AHIST2H4BH4FDHIST1H4AHIST1H4BdJ160A22.1H4/dHIST1H4EHIST1H4FHIST1H4CHIST1H4DHIST1H4IHIST1H4JHIST1H4HAutomatically obtained from Entrez Gene on 23-05-11BCL2L4Automatically obtained from Entrez Gene on 23-05-11H4FCH4H4/cAutomatically obtained from Entrez Gene on 23-05-11MGC3887BAKBCL2L7BAK-LIKEMGC117255CDN1Automatically obtained from Entrez Gene on 23-05-11PP2C-DELTAWIP1Automatically obtained from Entrez Gene on 23-05-11FLJ10416COP1RNF200Automatically obtained from Entrez Gene on 23-05-11HIST4H4HIST1H4LHIST1H4KHIST2H4AHIST1H4AHIST1H4BHIST1H4EHIST1H4FHIST1H4CH4/oHIST1H4DHIST1H4IHIST1H4JHIST1H4HAutomatically obtained from Entrez Gene on 23-05-11CDC25Automatically obtained from Entrez Gene on 23-05-11SCKL1MEC1SCKLFRP1Automatically obtained from Entrez Gene on 23-05-11MPFDNEM3NEM2NEM1CFTD1ASMACFTDCFTDMACTAAutomatically obtained from Entrez Gene on 23-05-11RAD4XP3XPCCAutomatically obtained from Entrez Gene on 23-05-11hVps34VPS34MGC61518Automatically obtained from Entrez Gene on 23-05-11URCC4MRG15BPFLJ10914MRGBPEaf7Automatically obtained from Entrez Gene on 23-05-11SEL10AGOFBX30FBXW6SEL-10CDC4FBXO30FBW7FLJ16457FBW6DKFZp686F23254Automatically obtained from Entrez Gene on 23-05-11DRP1MGC119312DRP-1Automatically obtained from Entrez Gene on 23-05-11SEST3MGC29667Automatically obtained from Entrez Gene on 23-05-11mcl1/EATMCL1SMcl-1MCL1-ESBCL2L3TMMCL1Lbcl2-L-3MGC104264EATMGC1839Automatically obtained from Entrez Gene on 23-05-11NIP3Automatically obtained from Entrez Gene on 23-05-11NIXBNIP3aAutomatically obtained from Entrez Gene on 23-05-11BZSMGC11227DECGLM2PTEN110q23delMMAC1TEP1MHAMAutomatically obtained from Entrez Gene on 23-05-11p55CDCbA276H19.3MGC102824CDC20AAutomatically obtained from Entrez Gene on 23-05-11MIRN125B1Automatically obtained from Entrez Gene on 23-05-11MIRN125B2Automatically obtained from Entrez Gene on 23-05-11MRG15MORFRG15S863-6Eaf3MGC10631MEAF3HsT17725Automatically obtained from Entrez Gene on 23-05-11PAD4PDI5PADI5PDI4PADAutomatically obtained from Entrez Gene on 23-05-11hMLH1FCC2COCA2HNPCCMGC5172HNPCC2Automatically obtained from Entrez Gene on 23-05-11PSK-J3CMM3MGC14458Automatically obtained from Entrez Gene on 23-05-11H3FIH3/iAutomatically obtained from Entrez Gene on 23-05-11PP1425CHK2HuCds1LFS2CDS1RAD53Automatically obtained from Entrez Gene on 23-05-11p33(CDK2)Automatically obtained from Entrez Gene on 23-05-11ACINUSKIAA0670DKFZp667N107fSAP152ACNAutomatically obtained from Entrez Gene on 23-05-11CIAP2c-IAP2HIAP1RNF49MALT2MIHCHAIP1API2AIP1Automatically obtained from Entrez Gene on 23-05-11ATDCTELO1ATCATDATEAT1TEL1ATAMGC74674DKFZp781A0353Automatically obtained from Entrez Gene on 23-05-11hIAP-3hIAP3IAP-3XLP2MIHABIRC4API3ILP1FLJ26913Automatically obtained from Entrez Gene on 23-05-11Rsc6pCRACD2BAF60BAutomatically obtained from Entrez Gene on 23-05-11API1c-IAP1RNF48HIAP2cIAP1MIHBHiap-2Automatically obtained from Entrez Gene on 23-05-11Rsc6pCRACD1BAF60AAutomatically obtained from Entrez Gene on 23-05-11MGC4631BOKLBCL2L9Automatically obtained from Entrez Gene on 23-05-11CRACC1Rsc8BAF155SRG3SWI3Automatically obtained from Entrez Gene on 23-05-11SNF5hSNFSSfh1pRTPS1INI1SNF5L1BAF47Snr1RDTAutomatically obtained from Entrez Gene on 23-05-11PO-GAA1RECC1RFC140MHCBFBMGC51786RFCAutomatically obtained from Entrez Gene on 23-05-11Rsc8DKFZp313D0632CRACC2BAF170Automatically obtained from Entrez Gene on 23-05-11BRMhSNF2aSNF2LASNF2L2Sth1pFLJ36757BAF190hBRMSNF2SWI2MGC74511Automatically obtained from Entrez Gene on 23-05-11hSNF2bSNF2L4FLJ39786SNF2LBRTPS2BAF190SNF2-BETASNF2SWI2BRG1Automatically obtained from Entrez Gene on 23-05-11FLJ00065Automatically obtained from Entrez Gene on 23-05-11HIST2H3AHIST2H3CAutomatically obtained from Entrez Gene on 23-05-11INO80KARPN-BETAArp4BAF53AACTL6MGC5382Automatically obtained from Entrez Gene on 23-05-11ADXRAutomatically obtained from Entrez Gene on 23-05-11FLJ41705Automatically obtained from Entrez Gene on 23-05-11SMAP2p120SMAPAutomatically obtained from Entrez Gene on 23-05-11VPS30ATG6beclin1Automatically obtained from Entrez Gene on 23-05-11MORT1MGC8528Automatically obtained from Entrez Gene on 23-05-11WDR79FLJ10385TCAB1Automatically obtained from Entrez Gene on 23-05-11CED4APAF-1DKFZp781B1145Automatically obtained from Entrez Gene on 23-05-11CAF-1CAF1P60CAF1CAF1AMPP7MPHOSPH7CAF-IP60Automatically obtained from Entrez Gene on 23-05-11BAF57FLJ35648Automatically obtained from Entrez Gene on 23-05-11PRAKAutomatically obtained from Entrez Gene on 23-05-11CCNACCN1Automatically obtained from Entrez Gene on 23-05-11KIAK0002MGC102758Automatically obtained from Entrez Gene on 23-05-11Rsc6pCRACD3BAF60CMGC111010Automatically obtained from Entrez Gene on 23-05-11Automatically obtained from Entrez Gene on 23-05-11CCNEAutomatically obtained from Entrez Gene on 23-05-11CCNGAutomatically obtained from Entrez Gene on 23-05-11BimLBAMBIM-beta7BimELBIM-alpha6BIMBODBIM-beta6Automatically obtained from Entrez Gene on 23-05-11p53DINP1TP53INP1BTP53INP1ADKFZp434M1317SIPTP53DINP1TeapFLJ22139Automatically obtained from Entrez Gene on 23-05-11MKP-1MKP1CL100HVH1PTPN10Automatically obtained from Entrez Gene on 23-05-11DKFZp761M02121DKFZp761M0212SES2HI95SEST2Automatically obtained from Entrez Gene on 23-05-11P21p21CIP1SDI1MDA-6CAP20WAF1CIP1CDKN1Automatically obtained from Entrez Gene on 23-05-11MLMP19ARFMTS-1P14CMM2P16ARFINK4P16INK4AP19CDK4ICDKN2MTS1P14ARFP16INK4TP16INK4AP16-INK4AAutomatically obtained from Entrez Gene on 23-05-11CAF1P150P150CAF-1MGC71229CAF1BCAF1Automatically obtained from Entrez Gene on 23-05-11PCA1MGC118792MGC118793DEPC-1DEPC1MGC118790ABH3FLJ43614Automatically obtained from Entrez Gene on 23-05-11H2AFGH2A.3H2A/gAutomatically obtained from Entrez Gene on 23-05-11H3.3AMGC87782MGC87783H3F3BH3F3Automatically obtained from Entrez Gene on 23-05-11P73Automatically obtained from Entrez Gene on 23-05-11CRE-BP1CREB2TREB7HB16MGC111558Automatically obtained from Entrez Gene on 23-05-11H3.3BH3F3AAutomatically obtained from Entrez Gene on 23-05-11PA26MGC138241MGC142129SEST1Automatically obtained from Entrez Gene on 23-05-11HDMXDKFZp781B1423MGC132766MDMXMRP1Automatically obtained from Entrez Gene on 23-05-11MGC5370HDMXhdm2MGC71221Automatically obtained from Entrez Gene on 23-05-11hHUS1Automatically obtained from Entrez Gene on 23-05-11GAS41B230215M10Rik4930573H17RikYAF9NUBI-1Automatically obtained from Entrez Gene on 23-05-11NALP1SLEV1DEFCAP-L/SNACPP1044DEFCAPVAMAS1KIAA0926DKFZp586O1822CARD7CLR17.1Automatically obtained from Entrez Gene on 23-05-11D6S182HSP90-BETAHSPC2FLJ26984HSPCBHSP90BAutomatically obtained from Entrez Gene on 23-05-11APT1LG1TNFSF6CD95-LCD178FASLCD95LAutomatically obtained from Entrez Gene on 23-05-11FAS1CD95APT1APO-1FASTMTNFRSF6ALPS1AAutomatically obtained from Entrez Gene on 23-05-11BIP1BP4NBKAutomatically obtained from Entrez Gene on 23-05-11FP497MGC42355MGC15319Automatically obtained from Entrez Gene on 23-05-11SIR2L1Automatically obtained from Entrez Gene on 23-05-11LCFS2HNPCCHNPCC1FCC1COCA1Automatically obtained from Entrez Gene on 23-05-11LMSNBPp73HSHFM4p40AISEEC3KETp53CPTP73Lp51p63OFC8p73LB(p51A)TP53CPRHSTP53LB(p51B)Automatically obtained from Entrez Gene on 23-05-11SAPK-3PRKM12P38GAMMAERK3ERK6SAPK3Automatically obtained from Entrez Gene on 23-05-11DUSPHVH3Automatically obtained from Entrez Gene on 23-05-11MGC138366p20253BP1FLJ41424Automatically obtained from Entrez Gene on 23-05-11ING2Eaf4p47ING3FLJ20089MEAF4Automatically obtained from Entrez Gene on 23-05-11TRP53FLJ92943P53LFS1Activators of transcriptionThis is a heterodimer complex composed of a large and a small subunit. It functions in nucleotide-excision repair. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in the gene encoding the large or small subunit. Ubiquitin-protein-ligase complexG1/S regulatorsestrins, a family of proteins whose expression is modulated by p53, are required for regeneration of Prxs containing Cys-SO(2)H, thus reestablishing the antioxidant firewall. Comlex involved in autophage
Development 135, 2347-2360 (2008)Involved in acetylation of taget proteins during DNA damage response
Mol Cell. 2006 21:51-64
also in; Current Opinion in Genetics and Development Volume 14, Issue 2, April 2004, Pages 147-154
The NuA4 histone acetyltransferase (HAT) multisubunit complex is responsible for acetylation of histone H4 and H2A N-terminal tails in yeast. The NuA4/Tip60 HAT complex is highly conserved in eukaryotes playing primary roles in transcription, cellular response to DNA damage, and cell cycle control. ING subunits are probably crucial for acetylation of chromatin substrates.
Pro-survival: Bcl2, Bcl2L1(BclXL variant), Bcl2l2 (BclW), MCL1 (Mcl1L varaint)Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). BH3 pro-apoptotic family- antagonist of the BCL-2 familyPro-apoptotic BAX familyp38, 4 genesHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). ERK signaling pathway plays a key role in several steps of tumorigenesis including cancer cell proliferation, migration, and invasion.Mediate ATPdependent chromatin remodeling processes that are critical for differentiation and proliferation.Oncogene (2009), 1-16The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also called activator 1, is a protein complex consisting of five distinct subunits of 145, 40, 38, 37, and 36.5 kD. JNK1=Mapk8, JNK2=Mapk9, JNK3=Mapk10Automated transferSer46 dephosphorylationAutomated transferAutomated transferAutomated transferPhosphorylation on Mdm2-Ser395Ser15 Ser18 (Tomimatsu 2007)Automated transferAutomated transferdephosphorylation of p53 at Thr55 by B56g-PP2A as an important event occurring after DNA damage, promoting p53 activationPhosphorylation on p53-Ser20p53AIP1 induced down-regulation of mitochondrial DeltaPsim and release of cytochrome c from mitochondria in human ceSer15Automated transferAutomated transferAutomated transferAutomated transferAutomated transferPeptidyl arginine deiminase 4 (PADI4) specifically deiminates, arginine residues R2, R8, R17, and R26 in the H3 tail.At the beginning of this reaction, 1 molecule of 'ATP', and 1 molecule of 'Chk2' are present. At the end of this reaction, 1 molecule of 'phospho-Chk2', and 1 molecule of 'ADP' are present.<br><br>This reaction takes place in the 'nucleus' and is mediated by the 'kinase activity' of 'phospho-ATM (Ser 1981)'.<br>Generated from Reactome catalysis kinase_activity_of_phospho_ATM__Ser_1981___nucleoplasm_3 and reaction Phosphorylation and activation of CHK2 by ATM(Phosphorylation_and_activation_of_CHK2_by_ATM)Turogh competing with the eo300 coactivator of p53 on the same site of interaction