Translation
type: MolecularInteraction
participant: PCNA_inactive
participant: PCNA_RNA

.Family.ERK....PROMOTES.TP53.
type: Catalysis
controlled: Phosphorylation.P.ERK.TP53
data source: Spike
controller: ERK.family
xref: 10781582
control type: ACTIVATION

BNIP3L
type: Protein
entity reference: BNIP3L

http://www.ncbi.nlm.nih.gov/#8550
type: UnificationXref
id: 8550
db: Entrez Gene

CAF-1.complex_inactive
type: Protein

CDKN1A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1026

19571673
type: PublicationXref
id: 19571673
title: Wrap53, a novel regulator of p53
db: PubMed

TP63_DNA
type: DnaRegion
entity reference: TP63

12944386
type: PublicationXref
id: 12944386
title: In vivo recruitment of XPC to UV-induced cyclobutane pyrimidine dimers by the DDB2 gene product
db: PubMed

7536190
type: PublicationXref
id: 7536190
title: A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain
db: PubMed

.BIRC2.INHIBITS.CASP9.
type: Catalysis
controlled: Physical.Interaction.I.BIRC2.CASP9
data source: Spike
controller: BIRC2
xref: 9545235
xref: 9990849
control type: INHIBITION

http://www.ncbi.nlm.nih.gov/#10346
type: UnificationXref
id: 10346
db: Entrez Gene

HSP90AB1_RNA
type: RnaRegion
entity reference: HSP90AB1

17634560
type: PublicationXref
id: 17634560
title: Polymorphic TP53BP1 and TP53 gene interactions associated with risk of squamous cell carcinoma of the head and neck
db: PubMed

APAF1_RNA
type: RnaRegion
entity reference: APAF1

http://www.ncbi.nlm.nih.gov/#896
type: UnificationXref
id: 896
db: Entrez Gene

MIR125B2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#406912

http://www.ncbi.nlm.nih.gov/#898
type: UnificationXref
id: 898
db: Entrez Gene

CASP8_inactive
type: Protein
entity reference: CASP8

.TP53.PROMOTES.LRDD.
type: TemplateReactionRegulation
controller: TP53
xref: 10973264
controlled: Transcription.Regulation.P.TP53.LRDD
data source: Spike
control type: ACTIVATION

CASP6
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#839

.TP53.PROMOTES.PPM1D.
type: TemplateReactionRegulation
controller: TP53
xref: 20093361
controlled: Transcription.Regulation.P.TP53.PPM1D
data source: Spike
control type: ACTIVATION

CASP6
type: Protein
entity reference: CASP6

PMS2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5395

.TP53.PROMOTES.PTEN.
type: TemplateReactionRegulation
controller: TP53
xref: 18431400
controlled: Transcription.Regulation.P.TP53.PTEN
data source: Spike
control type: ACTIVATION

TRIM22_DNA
type: DnaRegion
entity reference: TRIM22

Translation
type: MolecularInteraction
participant: TRIM22_RNA
participant: TRIM22

.TP53.PROMOTES.TP53AIP1.
type: TemplateReactionRegulation
controller: TP53
xref: 11030628
controlled: Transcription.Regulation.P.TP53.TP53AIP1
data source: Spike
control type: ACTIVATION

CCND1
type: Protein
entity reference: CCND1

MIR605
type: Protein
entity reference: MIR605

MDM4
type: Protein
entity reference: MDM4

.CASP3.PROMOTES.ACIN1.
type: Catalysis
controlled: Proteolytic.Processing.P.CASP3.ACIN1
data source: Spike
controller: CASP3
xref: 10490026
control type: ACTIVATION

DDB1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1642

.TP53.PROMOTES.MSH2.
type: TemplateReactionRegulation
controller: TP53
xref: 12209975
controlled: Transcription.Regulation.P.TP53.MSH2
data source: Spike
control type: ACTIVATION

18508759
type: PublicationXref
id: 18508759
title: MKP-1 represses JNK-mediated apoptosis via NF-kappa B regulation
db: PubMed

FAS_inactive
type: Protein
entity reference: FAS

http://www.ncbi.nlm.nih.gov/#665
type: UnificationXref
id: 665
db: Entrez Gene

Translation
type: MolecularInteraction
participant: TP53_inactive
participant: TP53_RNA

Translation
type: MolecularInteraction
participant: CASP1_RNA
participant: CASP1

BID
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#637

http://www.ncbi.nlm.nih.gov/#1869
type: UnificationXref
id: 1869
db: Entrez Gene

11313951
type: PublicationXref
id: 11313951
title: Negative regulation of bcl-2 expression by p53 in hematopoietic cells
db: PubMed

.TP53.INHIBITS.CDC20.
type: TemplateReactionRegulation
controller: TP53
xref: 19273532
controlled: Transcription.Regulation.I.TP53.CDC20
data source: Spike
control type: INHIBITION

9260156
type: PublicationXref
id: 9260156
title: Differential regulation of the p21/WAF-1 and mdm2 genes after high-dose UV irradiation: p53-dependent and p53-independent regulation of the mdm2 gene
db: PubMed

PRC1_RNA
type: RnaRegion
entity reference: PRC1

Translation
type: MolecularInteraction
participant: RAD51_RNA
participant: RAD51

C13orf15
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#28984

E2F1-3.family_inactive
type: Protein

GADD45A_DNA
type: DnaRegion
entity reference: GADD45A

ATR
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#545

.MDM4.INHIBITS.TP53.
type: Catalysis
controlled: Physical.Interaction.I.MDM4.TP53
data source: Spike
controller: MDM4
xref: 12963717
control type: INHIBITION

PMS2
type: Protein
entity reference: PMS2

DUSP1
type: Protein
entity reference: DUSP1

9922454
type: PublicationXref
id: 9922454
title: Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner
db: PubMed

.Complex.SWI/SNF....PROMOTES.TP53.
type: Catalysis
controlled: Other.P.SWI/SNF.TP53
data source: Spike
controller: SWI/SNF.complex
xref: 11950834
control type: ACTIVATION

BAX
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#581

MDM2_RNA
type: RnaRegion
entity reference: MDM2

http://www.ncbi.nlm.nih.gov/#7832
type: UnificationXref
id: 7832
db: Entrez Gene

20093361
type: PublicationXref
id: 20093361
title: Expression of a homeostatic regulator, Wip1 (wild-type p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation
db: PubMed

CDC20_RNA
type: RnaRegion
entity reference: CDC20

FDXR
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2232

BTG2_RNA
type: RnaRegion
entity reference: BTG2

PADI4
type: Protein
entity reference: PADI4

.MIR125B1.INHIBITS.TP53.
type: Catalysis
controlled: mRNA.stability.I.MIR125B1.TP53
data source: Spike
controller: MIR125B1
xref: 21741842
xref: 20542001
control type: INHIBITION

.TP53.PROMOTES.BNIP3L.
type: TemplateReactionRegulation
controller: TP53
xref: 18431400
controlled: Transcription.Regulation.P.TP53.BNIP3L
data source: Spike
control type: ACTIVATION

PRC1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9055

http://www.ncbi.nlm.nih.gov/#11200
type: UnificationXref
id: 11200
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#2074
type: UnificationXref
id: 2074
db: Entrez Gene

12370809
type: PublicationXref
id: 12370809
title: The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis
db: PubMed

CDKN2A
type: Protein
entity reference: CDKN2A

14627995
type: PublicationXref
id: 14627995
title: Gadd45a contributes to p53 stabilization in response to DNA damage
db: PubMed

BCL6_RNA
type: RnaRegion
entity reference: BCL6

PCNA
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5111

.TP53.PROMOTES.BID.
type: TemplateReactionRegulation
controller: TP53
xref: 12402042
xref: 18431400
controlled: Transcription.Regulation.P.TP53.BID
data source: Spike
control type: ACTIVATION

BNIP3L_RNA
type: RnaRegion
entity reference: BNIP3L

Translation
type: MolecularInteraction
participant: IER3
participant: IER3_RNA

http://www.ncbi.nlm.nih.gov/#1847
type: UnificationXref
id: 1847
db: Entrez Gene

20624280
type: PublicationXref
id: 20624280
title: Stress-specific response of the p53-Mdm2 feedback loop
db: PubMed

.TP53.PROMOTES.MLH1.
type: TemplateReactionRegulation
controller: TP53
xref: 15781865
controlled: Transcription.Regulation.P.TP53.MLH1
data source: Spike
control type: ACTIVATION

HSP90AB1_DNA
type: DnaRegion
entity reference: HSP90AB1

.BIRC2.INHIBITS.CASP3.
type: Catalysis
controlled: Physical.Interaction.I.BIRC2.CASP3
data source: Spike
controller: BIRC2
xref: 9384571
xref: 9990849
xref: 12042762
control type: INHIBITION

ATF2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1386

TP53_inactive
type: Protein
entity reference: TP53

BTG2
type: Protein
entity reference: BTG2

PMAIP1_RNA
type: RnaRegion
entity reference: PMAIP1

RFWD2
type: Protein
entity reference: RFWD2

RAD51
type: Protein
entity reference: RAD51

CASP1
type: Protein
entity reference: CASP1

Translation
type: MolecularInteraction
participant: BID_RNA
participant: BID

.TP53.PROMOTES.BTG2.
type: TemplateReactionRegulation
controller: TP53
xref: 8944033
xref: 10669755
controlled: Transcription.Regulation.P.TP53.BTG2
data source: Spike
control type: ACTIVATION

CDC25C
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#995

Translation
type: MolecularInteraction
participant: MIR605
participant: MIR605_RNA

.TP53.INHIBITS.IER3.
type: TemplateReactionRegulation
controller: TP53
xref: 18431400
controlled: Transcription.Regulation.I.TP53.IER3
data source: Spike
control type: INHIBITION

.TP53.PROMOTES.FBXW7.
type: TemplateReactionRegulation
controller: TP53
xref: 12824889
controlled: Transcription.Regulation.P.TP53.FBXW7
data source: Spike
control type: ACTIVATION

http://www.ncbi.nlm.nih.gov/#1642
type: UnificationXref
id: 1642
db: Entrez Gene

16044147
type: PublicationXref
id: 16044147
title: TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity
db: PubMed

ACIN1_inactive
type: Protein
entity reference: ACIN1

http://www.ncbi.nlm.nih.gov/#1643
type: UnificationXref
id: 1643
db: Entrez Gene

12833146
type: PublicationXref
id: 12833146
title: Induction of ATF3 by ionizing radiation is mediated via a signaling pathway that includes ATM, Nibrin1, stress-induced MAPkinases and ATF-2
db: PubMed

.TP53.PROMOTES.ATF3.
type: TemplateReactionRegulation
controller: TP53
xref: 18431400
controlled: Transcription.Regulation.P.TP53.ATF3
data source: Spike
control type: ACTIVATION

.TP53.PROMOTES.RB1.
type: TemplateReactionRegulation
controller: TP53
xref: 18431400
controlled: Transcription.Regulation.P.TP53.RB1
data source: Spike
control type: ACTIVATION

19139122
type: PublicationXref
id: 19139122
title: PP2A regulates ionizing radiation-induced apoptosis through Ser46 phosphorylation of p53
db: PubMed

15781865
type: PublicationXref
id: 15781865
title: Identification of the mismatch repair genes PMS2 and MLH1 as p53 target genes by using serial analysis of binding elements
db: PubMed

http://www.ncbi.nlm.nih.gov/#604
type: UnificationXref
id: 604
db: Entrez Gene

.TP53.INHIBITS.HSP90AB1.
type: TemplateReactionRegulation
controller: TP53
xref: 18431400
controlled: Transcription.Regulation.I.TP53.HSP90AB1
data source: Spike
control type: INHIBITION

Translation
type: MolecularInteraction
participant: CDC25C
participant: CDC25C_RNA

.SIRT1.INHIBITS.TP53.
type: Catalysis
controlled: Deacetylation.I.SIRT1.TP53
data source: Spike
controller: SIRT1
xref: 17964266
control type: INHIBITION

FASLG
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#356

DUSP5
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1847

BAX_RNA
type: RnaRegion
entity reference: BAX

XIAP
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#331

EGR1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1958

ATM
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#472

http://www.ncbi.nlm.nih.gov/#841
type: UnificationXref
id: 841
db: Entrez Gene

.TP53.PROMOTES.BAX.
type: TemplateReactionRegulation
controller: TP53
xref: 7834749
controlled: Transcription.Regulation.P.TP53.BAX
data source: Spike
control type: ACTIVATION

http://www.ncbi.nlm.nih.gov/#842
type: UnificationXref
id: 842
db: Entrez Gene

CCNE1_inactive
type: Protein
entity reference: CCNE1

http://www.ncbi.nlm.nih.gov/#843
type: UnificationXref
id: 843
db: Entrez Gene

CycD.family
type: Protein
data source: Spike
member physical entity: CCND3
member physical entity: CCND1
xref: TAU:F.000006

http://www.ncbi.nlm.nih.gov/#637
type: UnificationXref
id: 637
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#839
type: UnificationXref
id: 839
db: Entrez Gene

Translation
type: MolecularInteraction
participant: GTSE1_RNA
participant: GTSE1

http://www.ncbi.nlm.nih.gov/#834
type: UnificationXref
id: 834
db: Entrez Gene

.TP53.PROMOTES.RRM2B.
type: TemplateReactionRegulation
controller: TP53
xref: 12565178
controlled: Transcription.Regulation.P.TP53.RRM2B
data source: Spike
control type: ACTIVATION

TRAF4
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9618

http://www.ncbi.nlm.nih.gov/#836
type: UnificationXref
id: 836
db: Entrez Gene

12750368
type: PublicationXref
id: 12750368
title: The cell cycle-regulated protein human GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function
db: PubMed

CDC20_DNA
type: DnaRegion
entity reference: CDC20

Translation
type: MolecularInteraction
participant: CDKN2A
participant: CDKN2A_RNA

Translation
type: MolecularInteraction
participant: C13orf15
participant: C13orf15_RNA

http://www.ncbi.nlm.nih.gov/#10524
type: UnificationXref
id: 10524
db: Entrez Gene

Translation
type: MolecularInteraction
participant: TP53AIP1
participant: TP53AIP1_RNA

.CASP9.PROMOTES.CASP3.
type: Catalysis
controlled: Proteolytic.Processing.P.CASP9.CASP3
data source: Spike
controller: CASP9
xref: 9390557
control type: ACTIVATION

12019168
type: PublicationXref
id: 12019168
title: p53AIP1 regulates the mitochondrial apoptotic pathway
db: PubMed

http://www.ncbi.nlm.nih.gov/#1612
type: UnificationXref
id: 1612
db: Entrez Gene

DUSP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1843

CCND3_inactive
type: Protein
entity reference: CCND3

16328436
type: PublicationXref
id: 16328436
title: Cyclin-dependent kinase inhibitors CIP1 (p21) and KIP1 (p27) in ovarian cancer
db: PubMed

Sestrins.family_RNA
type: RnaRegion

TP53
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7157

12890671
type: PublicationXref
id: 12890671
title: The phosphatase MKP1 is a transcriptional target of p53 involved in cell cycle regulation
db: PubMed

.PCNA.PROMOTES.Complex.CAF.1...(CHAF1B).
type: Catalysis
controlled: Physical.Interaction.P.PCNA.CAF.1
data source: Spike
controller: PCNA
xref: 10648606
xref: 20112283
control type: ACTIVATION

MSH2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4436

RAD51_RNA
type: RnaRegion
entity reference: RAD51

.TP53AIP1.PROMOTES.Complex.apoptosome...(CYCS).
type: Catalysis
controlled: Indirect.P.TP53AIP1.apoptosome
data source: Spike
controller: TP53AIP1
xref: 12019168
control type: ACTIVATION

BAX fam.family_inactive
type: Protein

12556559
type: PublicationXref
id: 12556559
title: Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways
db: PubMed

CASP1_DNA
type: DnaRegion
entity reference: CASP1

FADD_inactive
type: Protein
entity reference: FADD

RB1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5925

.ATF2.PROMOTES.ATF3.
type: TemplateReactionRegulation
controller: ATF2
xref: 12833146
controlled: Transcription.Regulation.P.ATF2.ATF3
data source: Spike
control type: ACTIVATION

20112283
type: PublicationXref
id: 20112283
title: Histone modifications: crucial elements for damage response and chromatin restoration
db: PubMed

http://www.ncbi.nlm.nih.gov/#55135
type: UnificationXref
id: 55135
db: Entrez Gene

Translation
type: MolecularInteraction
participant: PRC1_RNA
participant: PRC1

IER3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8870

11709054
type: PublicationXref
id: 11709054
title: Mechanisms of p53-dependent apoptosis
db: PubMed

12574499
type: PublicationXref
id: 12574499
title: PUMA mediates the apoptotic response to p53 in colorectal cancer cells
db: PubMed

SCF.complex
type: Complex
data source: Spike
name: SCF-FBXW7
component: FBXW7

.TP53BP1.PROMOTES.TP53.
type: Catalysis
controlled: Physical.Interaction.P.TP53BP1.TP53
data source: Spike
controller: TP53BP1
xref: 17634560
control type: ACTIVATION

ACIN1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#22985

.EGR1.PROMOTES.CDKN1A.
type: TemplateReactionRegulation
controller: EGR1
xref: 12690110
controlled: Transcription.Regulation.P.EGR1.CDKN1A
data source: Spike
control type: ACTIVATION

.RB1.INHIBITS.Family.E2F1.3....
type: Catalysis
controlled: Physical.Interaction.I.RB1.E2F1.3
data source: Spike
controller: RB1
xref: 20686481
control type: INHIBITION

ACIN1
type: Protein
entity reference: ACIN1

http://www.ncbi.nlm.nih.gov/#467
type: UnificationXref
id: 467
db: Entrez Gene

BCL6_DNA
type: DnaRegion
entity reference: BCL6

CASP10
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#843

ATF3
type: Protein
entity reference: ATF3

CDC20
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#991

FDXR
type: Protein
entity reference: FDXR

http://www.ncbi.nlm.nih.gov/#5888
type: UnificationXref
id: 5888
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#63970
type: UnificationXref
id: 63970
db: Entrez Gene

MDM2
type: Protein
entity reference: MDM2

http://www.ncbi.nlm.nih.gov/#4193
type: UnificationXref
id: 4193
db: Entrez Gene

.TP53.PROMOTES.CDKN1A.
type: TemplateReactionRegulation
controller: TP53
xref: 12748190
xref: 21163364
xref: 19749794
controlled: Transcription.Regulation.P.TP53.CDKN1A
data source: Spike
control type: ACTIVATION

http://www.ncbi.nlm.nih.gov/#4194
type: UnificationXref
id: 4194
db: Entrez Gene

FAS_DNA
type: DnaRegion
entity reference: FAS

17272272
type: PublicationXref
id: 17272272
title: Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double strand breaks
db: PubMed

GTSE1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#51512

.ATM.PROMOTES.TP53.
type: Catalysis
controlled: Phosphorylation.P.ATM.TP53
data source: Spike
controller: ATM
xref: 9733515
xref: 9733514
xref: 9843217
control type: ACTIVATION

DUSP5
type: Protein
entity reference: DUSP5

http://www.ncbi.nlm.nih.gov/#472
type: UnificationXref
id: 472
db: Entrez Gene

10490026
type: PublicationXref
id: 10490026
title: Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation
db: PubMed

SIRT1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#23411

CAF-1.complex
type: Complex
data source: Spike
name: chromatin assembly factor 1

12963717
type: PublicationXref
id: 12963717
title: DNA damage-induced MDMX degradation is mediated by MDM2
db: PubMed

DDB2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1643

http://www.ncbi.nlm.nih.gov/#1647
type: UnificationXref
id: 1647
db: Entrez Gene

.Complex.NuA4....PROMOTES.TP53.
type: Catalysis
controlled: Other.P.NuA4.TP53
data source: Spike
controller: NuA4.complex
xref: 18784729
control type: ACTIVATION

.BIRC3.INHIBITS.CASP3.
type: Catalysis
controlled: Physical.Interaction.I.BIRC3.CASP3
data source: Spike
controller: BIRC3
xref: 9384571
xref: 9990849
xref: 12042762
control type: INHIBITION

BH3 fam.family
type: Protein
data source: Spike
member physical entity: BBC3
member physical entity: PMAIP1
xref: TAU:F.000016

12089322
type: PublicationXref
id: 12089322
title: Apoptotic threshold is lowered by p53 transactivation of caspase-6
db: PubMed

http://www.ncbi.nlm.nih.gov/#9618
type: UnificationXref
id: 9618
db: Entrez Gene

9228058
type: PublicationXref
id: 9228058
title: Characterization of Fas (Apo-1, CD95)-Fas ligand interaction
db: PubMed

.PPM1D.INHIBITS.ATM.
type: Catalysis
controlled: Dephosphorylation.I.PPM1D.ATM
data source: Spike
controller: PPM1D
xref: 16949371
control type: INHIBITION

CDC25C_DNA
type: DnaRegion
entity reference: CDC25C

DAPK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1612

.ATM.PROMOTES.CHEK2.
type: Catalysis
controlled: Phosphorylation.P.ATM.CHEK2
data source: Spike
controller: ATM
xref: 12773400
xref: 9889122
control type: ACTIVATION

PMAIP1_DNA
type: DnaRegion
entity reference: PMAIP1

.TP53.PROMOTES.CASP10.
type: TemplateReactionRegulation
controller: TP53
xref: 14688482
controlled: Transcription.Regulation.P.TP53.CASP10
data source: Spike
control type: ACTIVATION

TP53AIP1
type: Protein
entity reference: TP53AIP1

9230442
type: PublicationXref
id: 9230442
title: X-linked IAP is a direct inhibitor of cell-death proteases
db: PubMed

CycA-Cdk2.complex_inactive
type: Protein

XPC_inactive
type: Protein
entity reference: XPC

Translation
type: MolecularInteraction
participant: DUSP1_RNA
participant: DUSP1

TP53AIP1_DNA
type: DnaRegion
entity reference: TP53AIP1

miR-34.family_DNA
type: DnaRegion

9990849
type: PublicationXref
id: 9990849
title: IAP family proteins--suppressors of apoptosis
db: PubMed

.ERCC6.INHIBITS.TP53.
type: Catalysis
controlled: Physical.Interaction.I.ERCC6.TP53
data source: Spike
controller: ERCC6
xref: 19221478
xref: 18784753
control type: INHIBITION

CCNE1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#898

11950834
type: PublicationXref
id: 11950834
title: SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription
db: PubMed

CDKN1A_DNA
type: DnaRegion
entity reference: CDKN1A

.TP53.PROMOTES.TP63.
type: TemplateReactionRegulation
controller: TP53
xref: 18431400
controlled: Transcription.Regulation.P.TP53.TP63
data source: Spike
control type: ACTIVATION

HSP90AB1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3326

MLH1
type: Protein
entity reference: MLH1

.Complex.PP2A....PROMOTES.TP53.
type: Catalysis
controlled: Dephosphorylation.P.PP2A.TP53
data source: Spike
controller: PP2A.complex
xref: 21460856
xref: 17245430
control type: ACTIVATION

TRIM22_RNA
type: RnaRegion
entity reference: TRIM22

DUSP1_RNA
type: RnaRegion
entity reference: DUSP1

SESN3
type: Protein
entity reference: SESN3

WRAP53
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#55135

CASP10_DNA
type: DnaRegion
entity reference: CASP10

.Family.JNK....PROMOTES.TP53.
type: Catalysis
controlled: Phosphorylation.P.JNK.TP53
data source: Spike
controller: JNK.family
xref: 11283254
control type: ACTIVATION

Translation
type: MolecularInteraction
participant: BBC3
participant: BBC3_RNA

RFWD2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#64326

.TP53.PROMOTES.FDXR.
type: TemplateReactionRegulation
controller: TP53
xref: 12370809
controlled: Transcription.Regulation.P.TP53.FDXR
data source: Spike
control type: ACTIVATION

.PADI4.INHIBITS.Family.H4...(HIST2H4B).
type: Catalysis
controlled: Dephosphorylation.I.PADI4.H4
data source: Spike
controller: PADI4
xref: 15345777
control type: INHIBITION

http://www.ncbi.nlm.nih.gov/#27113
type: UnificationXref
id: 27113
db: Entrez Gene

.TP53.PROMOTES.TRIM22.
type: TemplateReactionRegulation
controller: TP53
xref: 18431400
controlled: Transcription.Regulation.P.TP53.TRIM22
data source: Spike
control type: ACTIVATION

DUSP5_DNA
type: DnaRegion
entity reference: DUSP5

MLH1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4292

PPM1D
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8493

C12orf5
type: Protein
entity reference: C12orf5

miR-34.family_RNA
type: RnaRegion

PRC1_DNA
type: DnaRegion
entity reference: PRC1

.Family.H3....PROMOTES.TP53BP1.
type: Catalysis
controlled: Physical.Interaction.P.H3.TP53BP1
data source: Spike
controller: H3.family
xref: 16774833
control type: ACTIVATION

10969818
type: PublicationXref
id: 10969818
title: p53 promotes selection for Fas-mediated apoptotic resistance
db: PubMed

MDM2_inactive
type: Protein
entity reference: MDM2

.TP53.PROMOTES.TP53INP1.
type: TemplateReactionRegulation
controller: TP53
xref: 19118006
xref: 12067065
controlled: Transcription.Regulation.P.TP53.TP53INP1
data source: Spike
control type: ACTIVATION

MLH1_DNA
type: DnaRegion
entity reference: MLH1

Translation
type: MolecularInteraction
participant: BCL6
participant: BCL6_RNA

http://www.ncbi.nlm.nih.gov/#51512
type: UnificationXref
id: 51512
db: Entrez Gene

Translation
type: MolecularInteraction
participant: DAPK1_RNA
participant: DAPK1

12773400
type: PublicationXref
id: 12773400
title: A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein
db: PubMed

.TP53.PROMOTES.PADI4.
type: TemplateReactionRegulation
controller: TP53
xref: 19843866
controlled: Transcription.Regulation.P.TP53.PADI4
data source: Spike
control type: ACTIVATION

Translation
type: MolecularInteraction
participant: CDKN1A
participant: CDKN1A_RNA

.XIAP.INHIBITS.CASP3.
type: Catalysis
controlled: Ubiquitination.I.XIAP.CASP3
data source: Spike
controller: XIAP
xref: 9230442
xref: 9525868
xref: 11447297
xref: 11927604
control type: INHIBITION

.Complex.RFC....PROMOTES.PCNA.
type: Catalysis
controlled: Physical.Interaction.P.RFC.PCNA
data source: Spike
controller: RFC.complex
xref: 14530260
control type: ACTIVATION

20639885
type: PublicationXref
id: 20639885
title: The C terminus of p53 binds the N-terminal domain of MDM2
db: PubMed

Translation
type: MolecularInteraction
participant: FDXR
participant: FDXR_RNA

Translation
type: MolecularInteraction
participant: TRAF4
participant: TRAF4_RNA

Translation
type: MolecularInteraction
participant: RRM2B
participant: RRM2B_RNA

.PADI4.INHIBITS.Family.H3...(HIST1H3F).
type: Catalysis
controlled: Other.I.PADI4.H3
data source: Spike
controller: PADI4
xref: 15339660
control type: INHIBITION

9384571
type: PublicationXref
id: 9384571
title: The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
db: PubMed

Translation
type: MolecularInteraction
participant: APAF1_inactive
participant: APAF1_RNA

CASP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#834

http://www.ncbi.nlm.nih.gov/#64326
type: UnificationXref
id: 64326
db: Entrez Gene

RRM2B_RNA
type: RnaRegion
entity reference: RRM2B

XPC
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7508

11447297
type: PublicationXref
id: 11447297
title: Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death
db: PubMed

ATM_inactive
type: Protein
entity reference: ATM

GADD45A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1647

CASP3
type: Protein
entity reference: CASP3

CDKN1A
type: Protein
entity reference: CDKN1A

RRM2B
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#50484

11390657
type: PublicationXref
id: 11390657
title: Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family
db: PubMed

CDC25C_RNA
type: RnaRegion
entity reference: CDC25C

19816404
type: PublicationXref
id: 19816404
title: ATM activates p53 by regulating MDM2 oligomerization and E3 processivity
db: PubMed

MAPK3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5595

.Family.p38....PROMOTES.TP53.
type: Catalysis
controlled: Phosphorylation.P.p38.TP53
data source: Spike
controller: p38.family
xref: 10781582
control type: ACTIVATION

.DUSP1.INHIBITS.Family.JNK....
type: Catalysis
controlled: Dephosphorylation.I.DUSP1.JNK
data source: Spike
controller: DUSP1
xref: 18508759
control type: INHIBITION

.TP53.PROMOTES.FASLG.
type: TemplateReactionRegulation
controller: TP53
xref: 10969818
controlled: Transcription.Regulation.P.TP53.FASLG
data source: Spike
control type: ACTIVATION

Translation
type: MolecularInteraction
participant: TP73_RNA
participant: TP73

BCL2-fam.family
type: Protein
data source: Spike
member physical entity: BCL2
xref: TAU:F.000015

12209154
type: PublicationXref
id: 12209154
title: The Bcl2 family: regulators of the cellular life-or-death switch
db: PubMed

15608685
type: PublicationXref
id: 15608685
title: dapk1, encoding an activator of a p19ARF-p53-mediated apoptotic checkpoint, is a transcription target of p53
db: PubMed

11971958
type: PublicationXref
id: 11971958
title: p53 Binds and activates the xeroderma pigmentosum DDB2 gene in humans but not mice
db: PubMed

.XIAP.INHIBITS.CASP9.
type: Catalysis
controlled: Physical.Interaction.I.XIAP.CASP9
data source: Spike
controller: XIAP
xref: 11927604
xref: 12042762
xref: 11390657
control type: INHIBITION

17912037
type: PublicationXref
id: 17912037
title: E2F-dependent induction of p14ARF during cell cycle re-entry in human T cells
db: PubMed

PPM1D
type: Protein
entity reference: PPM1D

RRM2B_DNA
type: DnaRegion
entity reference: RRM2B

10648606
type: PublicationXref
id: 10648606
title: A CAF-1-PCNA-mediated chromatin assembly pathway triggered by sensing DNA damage
db: PubMed

9606
type: UnificationXref
id: 9606
db: taxonomy

http://www.ncbi.nlm.nih.gov/#1843
type: UnificationXref
id: 1843
db: Entrez Gene

GADD45A
type: Protein
entity reference: GADD45A

18784729
type: PublicationXref
id: 18784729
title: Is there a code embedded in proteins that is based on post-translational modifications?
db: PubMed

18296440
type: PublicationXref
id: 18296440
title: Preferential dimethylation of histone H4 lysine 20 by Suv4-20
db: PubMed

p38.family
type: Protein
data source: Spike
xref: TAU:F.000010

15492238
type: PublicationXref
id: 15492238
title: COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas
db: PubMed

Translation
type: MolecularInteraction
participant: CDC20_RNA
participant: CDC20

10973264
type: PublicationXref
id: 10973264
title: Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis
db: PubMed

http://www.ncbi.nlm.nih.gov/#3364
type: UnificationXref
id: 3364
db: Entrez Gene

TP53AIP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#63970

CycD-Cdk4.complex
type: Complex
data source: Spike
name: CyclinD-CDK4
component: CycD.family

CDC25C
type: Protein
entity reference: CDC25C

GTSE1_DNA
type: DnaRegion
entity reference: GTSE1

CASP10_RNA
type: RnaRegion
entity reference: CASP10

http://www.ncbi.nlm.nih.gov/#1026
type: UnificationXref
id: 1026
db: Entrez Gene

Translation
type: MolecularInteraction
participant: MLH1_RNA
participant: MLH1

http://www.ncbi.nlm.nih.gov/#1029
type: UnificationXref
id: 1029
db: Entrez Gene

9843217
type: PublicationXref
id: 9843217
title: ATM associates with and phosphorylates p53: mapping the region of interaction
db: PubMed

PADI4
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#23569

12565178
type: PublicationXref
id: 12565178
title: Expression of p53R2, newly p53 target in oral normal epithelium, epithelial dysplasia and squamous cell carcinoma.
db: PubMed

10807576
type: PublicationXref
id: 10807576
title: Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
db: PubMed

CASP3_inactive
type: Protein
entity reference: CASP3

CycA-Cdk2.complex
type: Complex
data source: Spike
name: CycA-Cdk2

SESN1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#27244

19918835
type: PublicationXref
id: 19918835
title: Massively regulated genes: the example of TP53
db: PubMed

JNK.family
type: Protein
data source: Spike
xref: TAU:F.000008

PTEN
type: Protein
entity reference: PTEN

.TP53.PROMOTES.DDB2.
type: TemplateReactionRegulation
controller: TP53
xref: 11971958
controlled: Transcription.Regulation.P.TP53.DDB2
data source: Spike
control type: ACTIVATION

Translation
type: MolecularInteraction
participant: PPM1D_RNA
participant: PPM1D

SESN3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#143686

11077446
type: PublicationXref
id: 11077446
title: PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition
db: PubMed

MIR504
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#574507

Translation
type: MolecularInteraction
participant: MSH2
participant: MSH2_RNA

Translation
type: MolecularInteraction
participant: PMAIP1_RNA
participant: PMAIP1

20686481
type: PublicationXref
id: 20686481
title: Rb regulates fate choice and lineage commitment in vivo
db: PubMed

MIR605_DNA
type: DnaRegion
entity reference: MIR605

SWI/SNF.complex
type: Complex
data source: Spike
name: SWI/SNF

21460856
type: PublicationXref
id: 21460856
title: ATM-mediated phosphorylation activates the tumor-suppressive function of B56-PP2A
db: PubMed

.ATM.INHIBITS.MDM2.
type: Catalysis
controlled: Phosphorylation.I.ATM.MDM2
data source: Spike
controller: ATM
xref: 19816404
xref: 10611322
control type: INHIBITION

9841917
type: PublicationXref
id: 9841917
title: p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs
db: PubMed

BNIP3L_DNA
type: DnaRegion
entity reference: BNIP3L

Translation
type: MolecularInteraction
participant: BNIP3L
participant: BNIP3L_RNA

.TP53.INHIBITS.PRC1.
type: TemplateReactionRegulation
controller: TP53
xref: 15531928
controlled: Transcription.Regulation.I.TP53.PRC1
data source: Spike
control type: INHIBITION

E2F1
type: Protein
entity reference: E2F1

PTEN
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5728

BAX fam.family
type: Protein
data source: Spike
member physical entity: BAX
xref: TAU:F.000017

BBC3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#27113

.PPM1D.INHIBITS.CHEK2.
type: Catalysis
controlled: Dephosphorylation.I.PPM1D.CHEK2
data source: Spike
controller: PPM1D
xref: 16936775
control type: INHIBITION

CCND3
type: Protein
entity reference: CCND3

15339660
type: PublicationXref
id: 15339660
title: Histone deimination antagonizes arginine methylation
db: PubMed

16322760
type: PublicationXref
id: 16322760
title: p53 modulates homologous recombination by transcriptional regulation of the RAD51 gene
db: PubMed

.TP53.PROMOTES.Family.Sestrins..SESN2,.SESN3,.SESN1..
type: TemplateReactionRegulation
controller: TP53
xref: 15105503
controlled: Transcription.Regulation.P.TP53.Sestrins
data source: Spike
control type: ACTIVATION

17188038
type: PublicationXref
id: 17188038
title: A chaperone-dependent GSK3beta transitional intermediate mediates activation-loop autophosphorylation
db: PubMed

Translation
type: MolecularInteraction
participant: BCL2_RNA
participant: BCL2

9126929
type: PublicationXref
id: 9126929
title: Identification of amino acid residues important for ligand binding to Fas
db: PubMed

15459661
type: PublicationXref
id: 15459661
title: Connecting proliferation and apoptosis in development and disease
db: PubMed

ATF3_RNA
type: RnaRegion
entity reference: ATF3

http://www.ncbi.nlm.nih.gov/#8772
type: UnificationXref
id: 8772
db: Entrez Gene

.APAF1.PROMOTES.CASP9.
type: Catalysis
controlled: Physical.Interaction.P.APAF1.CASP9
data source: Spike
controller: APAF1
xref: 9922454
xref: 9488720
control type: ACTIVATION

BIRC2
type: Protein
entity reference: BIRC2

RAD51
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5888

Translation
type: MolecularInteraction
participant: CASP6_RNA
participant: CASP6

10974554
type: PublicationXref
id: 10974554
title: Cloning, chromosome mapping and functional characterization of a human homologue of murine gtse-1 (B99) gene
db: PubMed

18784753
type: PublicationXref
id: 18784753
title: CSB protein is (a direct target of HIF-1 and) a critical mediator of the hypoxic response
db: PubMed

FASLG_DNA
type: DnaRegion
entity reference: FASLG

RB1_RNA
type: RnaRegion
entity reference: RB1

http://www.ncbi.nlm.nih.gov/#574507
type: UnificationXref
id: 574507
db: Entrez Gene

CDKN2A_DNA
type: DnaRegion
entity reference: CDKN2A

CASP6_RNA
type: RnaRegion
entity reference: CASP6

http://www.ncbi.nlm.nih.gov/#23411
type: UnificationXref
id: 23411
db: Entrez Gene

DAPK1_RNA
type: RnaRegion
entity reference: DAPK1

CASP1_RNA
type: RnaRegion
entity reference: CASP1

12067065
type: PublicationXref
id: 12067065
title: P53-dependent expression of the stress-induced protein (SIP)
db: PubMed

16990795
type: PublicationXref
id: 16990795
title: Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit
db: PubMed

TP73
type: Protein
entity reference: TP73

CHEK2
type: Protein
entity reference: CHEK2

.CDKN1A.INHIBITS.CCND3.
type: Catalysis
controlled: Physical.Interaction.I.CDKN1A.CCND3
data source: Spike
controller: CDKN1A
xref: 16328436
control type: INHIBITION

PP2A.complex
type: Complex
data source: Spike
name: Protein phosphatase 2A

BID_RNA
type: RnaRegion
entity reference: BID

MLH1_RNA
type: RnaRegion
entity reference: MLH1

11927604
type: PublicationXref
id: 11927604
title: The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites
db: PubMed

17254968
type: PublicationXref
id: 17254968
title: PRAK is essential for ras-induced senescence and tumor suppression
db: PubMed

CASP3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#836

Translation
type: MolecularInteraction
participant: RB1
participant: RB1_RNA

APAF1
type: Protein
entity reference: APAF1

TP53BP1
type: Protein
entity reference: TP53BP1

TP53_DNA
type: DnaRegion
entity reference: TP53

.MAPKAPK5.PROMOTES.TP53.
type: Catalysis
controlled: Phosphorylation.P.MAPKAPK5.TP53
data source: Spike
controller: MAPKAPK5
xref: 17254968
xref: 18568040
control type: ACTIVATION

BTG2_DNA
type: DnaRegion
entity reference: BTG2

7538907
type: PublicationXref
id: 7538907
title: FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
db: PubMed

http://www.ncbi.nlm.nih.gov/#5111
type: UnificationXref
id: 5111
db: Entrez Gene

FASLG_RNA
type: RnaRegion
entity reference: FASLG

CDC20
type: Protein
entity reference: CDC20

BCL2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#596

MAPK3
type: Protein
entity reference: MAPK3

http://www.ncbi.nlm.nih.gov/#1386
type: UnificationXref
id: 1386
db: Entrez Gene

TP73
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7161

20542001
type: PublicationXref
id: 20542001
db: PubMed

DAPK1
type: Protein
entity reference: DAPK1

.TP53.PROMOTES.PMS2.
type: TemplateReactionRegulation
controller: TP53
xref: 18431400
controlled: Transcription.Regulation.P.TP53.PMS2
data source: Spike
control type: ACTIVATION

DUSP5_RNA
type: RnaRegion
entity reference: DUSP5

http://www.ncbi.nlm.nih.gov/#5395
type: UnificationXref
id: 5395
db: Entrez Gene

.EGR1.PROMOTES.TP53.
type: TemplateReactionRegulation
controller: EGR1
xref: 12384981
controlled: Transcription.Regulation.P.EGR1.TP53
data source: Spike
control type: ACTIVATION

CCNG1_DNA
type: DnaRegion
entity reference: CCNG1

19579266
type: PublicationXref
id: 19579266
title: Efficient activation of p53 pathway in A549 cells exposed to L2, a novel compound targeting p53-MDM2 interaction
db: PubMed

11423996
type: PublicationXref
id: 11423996
title: DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1
db: PubMed

SESN2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#83667

19273532
type: PublicationXref
id: 19273532
title: DNA damage induced p53 downregulates Cdc20 by direct binding to its promoter causing chromatin remodeling
db: PubMed

TP73_RNA
type: RnaRegion
entity reference: TP73

19843866
type: PublicationXref
id: 19843866
title: Regulation of protein Citrullination through p53/PADI4 network in DNA damage response
db: PubMed

17964266
type: PublicationXref
id: 17964266
title: Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity
db: PubMed

H4.family_inactive
type: Protein

.FADD.PROMOTES.CASP8.
type: Catalysis
controlled: Physical.Interaction.P.FADD.CASP8
data source: Spike
controller: FADD
xref: 8681376
control type: ACTIVATION

Translation
type: MolecularInteraction
participant: TP53INP1_RNA
participant: TP53INP1

16912047
type: PublicationXref
id: 16912047
title: E2F1 modulates p38 MAPK phosphorylation via transcriptional regulation of ASK1 and Wip1
db: PubMed

CHEK2_inactive
type: Protein
entity reference: CHEK2

http://www.ncbi.nlm.nih.gov/#83667
type: UnificationXref
id: 83667
db: Entrez Gene

.KAT5.PROMOTES.TP53.
type: Catalysis
controlled: Acetylation.P.KAT5.TP53
data source: Spike
controller: KAT5
xref: 17188038
control type: ACTIVATION

FDXR_DNA
type: DnaRegion
entity reference: FDXR

http://www.ncbi.nlm.nih.gov/#55294
type: UnificationXref
id: 55294
db: Entrez Gene

GADD45A_RNA
type: RnaRegion
entity reference: GADD45A

CDKN2A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1029

http://www.ncbi.nlm.nih.gov/#50484
type: UnificationXref
id: 50484
db: Entrez Gene

PMAIP1
type: Protein
entity reference: PMAIP1

RB1_DNA
type: DnaRegion
entity reference: RB1

RFC.complex
type: Complex
data source: Spike
name: Replication Factor C

ATR
type: Protein
entity reference: ATR

C12orf5_RNA
type: RnaRegion
entity reference: C12orf5

DDB1
type: Protein
entity reference: DDB1

CCND1_inactive
type: Protein
entity reference: CCND1

TP53AIP1_RNA
type: RnaRegion
entity reference: TP53AIP1

15345777
type: PublicationXref
id: 15345777
title: Human PAD4 regulates histone arginine methylation levels via demethylimination
db: PubMed

18568040
type: PublicationXref
id: 18568040
title: Ras oncogenes: split personalities
db: PubMed

11437602
type: PublicationXref
id: 11437602
title: [W206R]-procaspase 3: an inactivatable substrate for caspase 8
db: PubMed

CASP9_inactive
type: Protein
entity reference: CASP9

MDM2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4193

http://www.ncbi.nlm.nih.gov/#7158
type: UnificationXref
id: 7158
db: Entrez Gene

8944033
type: PublicationXref
id: 8944033
title: Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway
db: PubMed

http://www.ncbi.nlm.nih.gov/#7157
type: UnificationXref
id: 7157
db: Entrez Gene

BCL6
type: Protein
entity reference: BCL6

WRAP53
type: Protein
entity reference: WRAP53

.TP53.PROMOTES.CASP1.
type: TemplateReactionRegulation
controller: TP53
xref: 18431400
controlled: Transcription.Regulation.P.TP53.CASP1
data source: Spike
control type: ACTIVATION

7915517
type: PublicationXref
id: 7915517
title: Transcriptional regulation of the PCNA promoter by p53
db: PubMed

PPM1D_RNA
type: RnaRegion
entity reference: PPM1D

http://www.ncbi.nlm.nih.gov/#7161
type: UnificationXref
id: 7161
db: Entrez Gene

CASP8
type: Protein
entity reference: CASP8

.TP53.PROMOTES.CCNG1.
type: TemplateReactionRegulation
controller: TP53
xref: 12556559
controlled: Transcription.Regulation.P.TP53.CCNG1
data source: Spike
control type: ACTIVATION

Translation
type: MolecularInteraction
participant: TP63
participant: TP63_RNA

CASP6_DNA
type: DnaRegion
entity reference: CASP6

ERCC6
type: Protein
entity reference: ERCC6

ATM
type: Protein
entity reference: ATM

11463392
type: PublicationXref
id: 11463392
title: PUMA, a novel proapoptotic gene, is induced by p53
db: PubMed

.TP53.PROMOTES.C12orf5.
type: TemplateReactionRegulation
controller: TP53
xref: 16839880
controlled: Transcription.Regulation.P.TP53.C12orf5
data source: Spike
control type: ACTIVATION

KAT5
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#10524

http://www.ncbi.nlm.nih.gov/#3326
type: UnificationXref
id: 3326
db: Entrez Gene

BCL2_RNA
type: RnaRegion
entity reference: BCL2

FBXW7
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#55294

11030628
type: PublicationXref
id: 11030628
title: p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53
db: PubMed

Translation
type: MolecularInteraction
participant: GADD45A
participant: GADD45A_RNA

Translation
type: MolecularInteraction
participant: CASP10
participant: CASP10_RNA

MAPKAPK5
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8550

ATF3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#467

BTG2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7832

.TP53.PROMOTES.DUSP5.
type: TemplateReactionRegulation
controller: TP53
xref: 12944906
controlled: Transcription.Regulation.P.TP53.DUSP5
data source: Spike
control type: ACTIVATION

Translation
type: MolecularInteraction
participant: LRDD
participant: LRDD_RNA

PADI4_DNA
type: DnaRegion
entity reference: PADI4

.FBXW7.INHIBITS.CCNE1.
type: Catalysis
controlled: Ubiquitination.I.FBXW7.CCNE1
data source: Spike
controller: FBXW7
xref: 12824889
control type: INHIBITION

C12orf5
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#57103

RB1
type: Protein
entity reference: RB1

.DUSP5.INHIBITS.MAPK3.
type: Catalysis
controlled: Dephosphorylation.I.DUSP5.MAPK3
data source: Spike
controller: DUSP5
xref: 12944906
control type: INHIBITION

Homo sapiens
type: BioSource
xref: 9606

.TP53.PROMOTES.PMAIP1.
type: TemplateReactionRegulation
controller: TP53
xref: 10807576
controlled: Transcription.Regulation.P.TP53.PMAIP1
data source: Spike
control type: ACTIVATION

9525868
type: PublicationXref
id: 9525868
title: A single BIR domain of XIAP sufficient for inhibiting caspases
db: PubMed

http://www.ncbi.nlm.nih.gov/#4436
type: UnificationXref
id: 4436
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#355
type: UnificationXref
id: 355
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#356
type: UnificationXref
id: 356
db: Entrez Gene

TAU:F.000011
type: UnificationXref
id: TAU:F-000011
db: Spike DB

TAU:F.000010
type: UnificationXref
id: TAU:F-000010
db: Spike DB

TAU:F.000015
type: UnificationXref
id: TAU:F-000015
db: Spike DB

TAU:F.000017
type: UnificationXref
id: TAU:F-000017
db: Spike DB

TAU:F.000016
type: UnificationXref
id: TAU:F-000016
db: Spike DB

JNK.family_inactive
type: Protein

CASP8
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#841

C12orf5_DNA
type: DnaRegion
entity reference: C12orf5

.Family.BCL2.fam..BCL2..INHIBITS.Family.BAX.fam..BAX..
type: Catalysis
controlled: Other.I.BCL2.fam.BAX.fam
data source: Spike
controller: BCL2-fam.family
xref: 12209154
control type: INHIBITION

MIR605_RNA
type: RnaRegion
entity reference: MIR605

19221478
type: PublicationXref
id: 19221478
title: Cockayne syndrome B protein (CSB): linking p53, HIF-1 and p300 to robustness, lifespan, cancer and cell fate decisions
db: PubMed

http://www.ncbi.nlm.nih.gov/#5595
type: UnificationXref
id: 5595
db: Entrez Gene

TRAF4
type: Protein
entity reference: TRAF4

.Complex.PP2A....INHIBITS.TP53.
type: Catalysis
controlled: Dephosphorylation.I.PP2A.TP53
data source: Spike
controller: PP2A.complex
xref: 19139122
control type: INHIBITION

16936775
type: PublicationXref
id: 16936775
title: The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase
db: PubMed

MIR504
type: Protein
entity reference: MIR504

FAS
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#355

Translation
type: MolecularInteraction
participant: CCNG1_RNA
participant: CCNG1

CCND3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#896

FDXR_RNA
type: RnaRegion
entity reference: FDXR

DAPK1_DNA
type: DnaRegion
entity reference: DAPK1

.Family.E2F1.3....PROMOTES.CDKN2A.
type: TemplateReactionRegulation
controller: E2F1-3.family
xref: 11491305
xref: 17912037
controlled: Transcription.Regulation.P.E2F1.3.CDKN2A
data source: Spike
control type: ACTIVATION

9733515
type: PublicationXref
id: 9733515
title: Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
db: PubMed

.PPM1D.INHIBITS.Family.p38....
type: Catalysis
controlled: Dephosphorylation.I.PPM1D.p38
data source: Spike
controller: PPM1D
xref: 20093361
control type: INHIBITION

9733514
type: PublicationXref
id: 9733514
title: Enhanced phosphorylation of p53 by ATM in response to DNA damage
db: PubMed

http://www.ncbi.nlm.nih.gov/#330
type: UnificationXref
id: 330
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#331
type: UnificationXref
id: 331
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#329
type: UnificationXref
id: 329
db: Entrez Gene

.MDM2.INHIBITS.TP53.
type: Catalysis
controlled: Physical.Interaction.I.MDM2.TP53
data source: Spike
controller: MDM2
xref: 11331603
xref: 20639885
xref: 19579266
control type: INHIBITION

.Complex.DDB1.2.(XPE)..DDB1,.DDB2..PROMOTES.XPC.
type: Catalysis
controlled: Physical.Interaction.P.DDB1.2.(XPE).XPC
data source: Spike
controller: DDB1-2 (XPE).complex
xref: 12944386
control type: ACTIVATION

CASP9
type: Protein
entity reference: CASP9

SESN2
type: Protein
entity reference: SESN2

CycD-Cdk4.complex_inactive
type: Protein

CHEK2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#11200

.TP53.PROMOTES.DUSP1.
type: TemplateReactionRegulation
controller: TP53
xref: 12890671
controlled: Transcription.Regulation.P.TP53.DUSP1
data source: Spike
control type: ACTIVATION

RRM2B
type: Protein
entity reference: RRM2B

Translation
type: MolecularInteraction
participant: miR-34.family_RNA
participant: miR-34.family

18431400
type: PublicationXref
id: 18431400
title: Transcriptional control of human p53-regulated genes
db: PubMed

http://www.ncbi.nlm.nih.gov/#545
type: UnificationXref
id: 545
db: Entrez Gene

CDKN1A_RNA
type: RnaRegion
entity reference: CDKN1A

BID_DNA
type: DnaRegion
entity reference: BID

.TP53.PROMOTES.TRAF4.
type: TemplateReactionRegulation
controller: TP53
xref: 12788948
controlled: Transcription.Regulation.P.TP53.TRAF4
data source: Spike
control type: ACTIVATION

MIR125B1
type: Protein
entity reference: MIR125B1

.TP53.PROMOTES.BBC3.
type: TemplateReactionRegulation
controller: TP53
xref: 11463392
xref: 12574499
controlled: Transcription.Regulation.P.TP53.BBC3
data source: Spike
control type: ACTIVATION

19749794
type: PublicationXref
id: 19749794
title: Pro-proliferative FoxM1 is a target of p53-mediated repression
db: PubMed

apoptosome.complex_inactive
type: Protein

11559530
type: PublicationXref
id: 11559530
title: APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis
db: PubMed

Sestrins.family_DNA
type: DnaRegion

SESN1
type: Protein
entity reference: SESN1

BCL2_DNA
type: DnaRegion
entity reference: BCL2

TP53BP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7158

http://www.ncbi.nlm.nih.gov/#9055
type: UnificationXref
id: 9055
db: Entrez Gene

ERK.family
type: Protein
data source: Spike
xref: TAU:F.000011

BIRC3
type: Protein
entity reference: BIRC3

.TP53.PROMOTES.TP73.
type: TemplateReactionRegulation
controller: TP53
xref: 18431400
controlled: Transcription.Regulation.P.TP53.TP73
data source: Spike
control type: ACTIVATION

15105503
type: PublicationXref
id: 15105503
title: Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD
db: PubMed

.TP73.PROMOTES.TP53INP1.
type: TemplateReactionRegulation
controller: TP73
xref: 16044147
controlled: Transcription.Regulation.P.TP73.TP53INP1
data source: Spike
control type: ACTIVATION

.BTG2.INHIBITS.CCND1.
type: Catalysis
controlled: Other.I.BTG2.CCND1
data source: Spike
controller: BTG2
xref: 10669755
control type: INHIBITION

Translation
type: MolecularInteraction
participant: FASLG
participant: FASLG_RNA

TRIM22
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#10346

http://www.ncbi.nlm.nih.gov/#595
type: UnificationXref
id: 595
db: Entrez Gene

.CDKN2A.INHIBITS.Complex.CycD.Cdk4..Family.CycD..CCND1,.CCND3...
type: Catalysis
controlled: Physical.Interaction.I.CDKN2A.CycD.Cdk4
data source: Spike
controller: CDKN2A
xref: 15459661
control type: INHIBITION

http://www.ncbi.nlm.nih.gov/#596
type: UnificationXref
id: 596
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#5366
type: UnificationXref
id: 5366
db: Entrez Gene

Spike
type: Provenance

16949371
type: PublicationXref
id: 16949371
title: Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways
db: PubMed

.BAX.PROMOTES.APAF1.
type: Catalysis
controlled: Other.P.BAX.APAF1
data source: Spike
controller: BAX
xref: 11709054
control type: ACTIVATION

http://www.ncbi.nlm.nih.gov/#995
type: UnificationXref
id: 995
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#991
type: UnificationXref
id: 991
db: Entrez Gene

p38.family_inactive
type: Protein

Translation
type: MolecularInteraction
participant: DDB2_RNA
participant: DDB2

.TP53.PROMOTES.MIR605.
type: TemplateReactionRegulation
controller: TP53
xref: 21217645
controlled: Transcription.Regulation.P.TP53.MIR605
data source: Spike
control type: ACTIVATION

Translation
type: MolecularInteraction
participant: FAS_RNA
participant: FAS_inactive

.TP53.PROMOTES.DAPK1.
type: TemplateReactionRegulation
controller: TP53
xref: 15608685
controlled: Transcription.Regulation.P.TP53.DAPK1
data source: Spike
control type: ACTIVATION

miR-34.family
type: Protein
data source: Spike
xref: TAU:F.329942

CCNG1
type: Protein
entity reference: CCNG1

FADD
type: Protein
entity reference: FADD

MDM4
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4194

http://www.ncbi.nlm.nih.gov/#7508
type: UnificationXref
id: 7508
db: Entrez Gene

CCNG1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#900

FADD
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8772

http://www.ncbi.nlm.nih.gov/#317
type: UnificationXref
id: 317
db: Entrez Gene

IER3_RNA
type: RnaRegion
entity reference: IER3

ATF3_DNA
type: DnaRegion
entity reference: ATF3

.TP53.PROMOTES.Family.miR.34...(MIR34A).
type: TemplateReactionRegulation
controller: TP53
xref: 18451145
controlled: Transcription.Regulation.P.TP53.miR.34
data source: Spike
control type: ACTIVATION

DDB1-2 (XPE).complex
type: Complex
data source: Spike
name: xeroderma pigmentosum complementation group E
component: DDB2
component: DDB1

H3.family
type: Protein
data source: Spike
xref: ELK:F.000028

18451145
type: PublicationXref
id: 18451145
title: Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence
db: PubMed

http://www.ncbi.nlm.nih.gov/#4292
type: UnificationXref
id: 4292
db: Entrez Gene

EGR1
type: Protein
entity reference: EGR1

.TP53.PROMOTES.PCNA.
type: TemplateReactionRegulation
controller: TP53
xref: 7915517
controlled: Transcription.Regulation.P.TP53.PCNA
data source: Spike
control type: ACTIVATION

http://www.ncbi.nlm.nih.gov/#5925
type: UnificationXref
id: 5925
db: Entrez Gene

Translation
type: MolecularInteraction
participant: PMS2_RNA
participant: PMS2

15838523
type: PublicationXref
id: 15838523
title: The p53 pathway: positive and negative feedback loops
db: PubMed

LRDD_DNA
type: DnaRegion
entity reference: LRDD

10611322
type: PublicationXref
id: 10611322
title: Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage.
db: PubMed

TP63_RNA
type: RnaRegion
entity reference: TP63

.TP53.PROMOTES.GADD45A.
type: TemplateReactionRegulation
controller: TP53
xref: 16990795
xref: 14627995
xref: 15603758
controlled: Transcription.Regulation.P.TP53.GADD45A
data source: Spike
control type: ACTIVATION

FBXW7
type: Protein
entity reference: FBXW7

17245430
type: PublicationXref
id: 17245430
title: A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55
db: PubMed

apoptosome.complex
type: Complex
data source: Spike
name: APAF1-CASP9 precursor

http://www.ncbi.nlm.nih.gov/#581
type: UnificationXref
id: 581
db: Entrez Gene

BIRC3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#330

http://www.ncbi.nlm.nih.gov/#5728
type: UnificationXref
id: 5728
db: Entrez Gene

TP73_DNA
type: DnaRegion
entity reference: TP73

http://www.ncbi.nlm.nih.gov/#8626
type: UnificationXref
id: 8626
db: Entrez Gene

21741842
type: PublicationXref
id: 21741842
title: miRNA response to DNA damage
db: PubMed

MAPKAPK5
type: Protein
entity reference: MAPKAPK5

TP63
type: Protein
entity reference: TP63

11491305
type: PublicationXref
id: 11491305
title: Computer-assisted identification of cell cycle-related genes: new targets for E2F transcription factors.
db: PubMed

H3.family_inactive
type: Protein

PCNA_RNA
type: RnaRegion
entity reference: PCNA

12788948
type: PublicationXref
id: 12788948
title: Identification and characterization of the cytoplasmic protein TRAF4 as a p53 regulated pro-apoptotic gene
db: PubMed

MDM2_DNA
type: DnaRegion
entity reference: MDM2

MSH2
type: Protein
entity reference: MSH2

MIR125B1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#406911

12824889
type: PublicationXref
id: 12824889
title: hCDC4b, a regulator of cyclin E, as a direct transcriptional target of p53
db: PubMed

APAF1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#317

9889122
type: PublicationXref
id: 9889122
title: A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
db: PubMed

NuA4.complex
type: Complex
data source: Spike
name: NuA4/Tip60 HAT complex

PCNA_inactive
type: Protein
entity reference: PCNA

http://www.ncbi.nlm.nih.gov/#8870
type: UnificationXref
id: 8870
db: Entrez Gene

KAT5
type: Protein
entity reference: KAT5

12383116
type: PublicationXref
id: 12383116
title: Highly potent p21(WAF1)-derived peptide inhibitors of CDK-mediated pRb phosphorylation: delineation and structural insight into their interactions with cyclin A
db: PubMed

DUSP1_DNA
type: DnaRegion
entity reference: DUSP1

MAPK3_inactive
type: Protein
entity reference: MAPK3

TP53INP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#94241

BID
type: Protein
entity reference: BID

RAD51_DNA
type: DnaRegion
entity reference: RAD51

12042762
type: PublicationXref
id: 12042762
title: IAP proteins: blocking the road to death's door
db: PubMed

TP53
type: Protein
entity reference: TP53

TP53INP1
type: Protein
entity reference: TP53INP1

15603758
type: PublicationXref
id: 15603758
title: Gadd45a, a p53- and BRCA1-regulated stress protein, in cellular response to DNA damage
db: PubMed

.MIR504.INHIBITS.TP53.
type: Catalysis
controlled: mRNA.stability.I.MIR504.TP53
data source: Spike
controller: MIR504
xref: 21741842
xref: 20542001
control type: INHIBITION

BNIP3L
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#665

HUS1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3364

PTEN_DNA
type: DnaRegion
entity reference: PTEN

9765224
type: PublicationXref
id: 9765224
title: Pro-caspase-3 is a major physiologic target of caspase-8
db: PubMed

ELK:F.000028
type: UnificationXref
id: ELK:F-000028
db: Spike DB

.TP53.INHIBITS.BCL2.
type: TemplateReactionRegulation
controller: TP53
xref: 19555669
xref: 8205530
xref: 11313951
controlled: Transcription.Regulation.I.TP53.BCL2
data source: Spike
control type: INHIBITION

Translation
type: MolecularInteraction
participant: BTG2
participant: BTG2_RNA

ELK:F.000029
type: UnificationXref
id: ELK:F-000029
db: Spike DB

15531928
type: PublicationXref
id: 15531928
title: Identification of PRC1 as the p53 target gene uncovers a novel function of p53 in the regulation of cytokinesis
db: PubMed

CCNE1
type: Protein
entity reference: CCNE1

http://www.ncbi.nlm.nih.gov/#27244
type: UnificationXref
id: 27244
db: Entrez Gene

.FAS.PROMOTES.FADD.
type: Catalysis
controlled: Physical.Interaction.P.FAS.FADD
data source: Spike
controller: FAS
xref: 8967952
xref: 7536190
xref: 7538907
control type: ACTIVATION

11331603
type: PublicationXref
id: 11331603
title: ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage
db: PubMed

DDB2_RNA
type: RnaRegion
entity reference: DDB2

MIR605
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#693190

.TP53.PROMOTES.GTSE1.
type: TemplateReactionRegulation
controller: TP53
xref: 12750368
xref: 10974554
controlled: Transcription.Regulation.P.TP53.GTSE1
data source: Spike
control type: ACTIVATION

Translation
type: MolecularInteraction
participant: C12orf5_RNA
participant: C12orf5

.HUS1.PROMOTES.PCNA.
type: Catalysis
controlled: Physical.Interaction.P.HUS1.PCNA
data source: Spike
controller: HUS1
xref: 11077446
control type: ACTIVATION

FAS_RNA
type: RnaRegion
entity reference: FAS

.TP53.PROMOTES.C13orf15.
type: TemplateReactionRegulation
controller: TP53
xref: 18431400
controlled: Transcription.Regulation.P.TP53.C13orf15
data source: Spike
control type: ACTIVATION

http://www.ncbi.nlm.nih.gov/#2232
type: UnificationXref
id: 2232
db: Entrez Gene

12384981
type: PublicationXref
id: 12384981
title: Regulation of life and death by the zinc finger transcription factor Egr-1
db: PubMed

http://www.ncbi.nlm.nih.gov/#900
type: UnificationXref
id: 900
db: Entrez Gene

GTSE1_RNA
type: RnaRegion
entity reference: GTSE1

HUS1
type: Protein
entity reference: HUS1

APAF1_DNA
type: DnaRegion
entity reference: APAF1

C13orf15_DNA
type: DnaRegion
entity reference: C13orf15

12748190
type: PublicationXref
id: 12748190
title: p21/CDKN1A mediates negative regulation of transcription by p53
db: PubMed

9390557
type: PublicationXref
id: 9390557
title: Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
db: PubMed

8205530
type: PublicationXref
id: 8205530
title: Identification of a p53-dependent negative response element in the bcl-2 gene
db: PubMed

Translation
type: MolecularInteraction
participant: PTEN
participant: PTEN_RNA

IER3_DNA
type: DnaRegion
entity reference: IER3

.TP53.PROMOTES.FAS.
type: TemplateReactionRegulation
controller: TP53
xref: 9841917
controlled: Transcription.Regulation.P.TP53.FAS
data source: Spike
control type: ACTIVATION

7834749
type: PublicationXref
id: 7834749
title: Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
db: PubMed

Translation
type: MolecularInteraction
participant: FBXW7
participant: FBXW7_RNA

12402042
type: PublicationXref
id: 12402042
title: BID regulation by p53 contributes to chemosensitivity
db: PubMed

19218832
type: PublicationXref
id: 19218832
title: Chromatin dynamics coupled to DNA repair
db: PubMed

Translation
type: MolecularInteraction
participant: HSP90AB1
participant: HSP90AB1_RNA

TP63
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8626

TP53BP1_inactive
type: Protein
entity reference: TP53BP1

BAX
type: Protein
entity reference: BAX

http://www.ncbi.nlm.nih.gov/#693190
type: UnificationXref
id: 693190
db: Entrez Gene

C13orf15_RNA
type: RnaRegion
entity reference: C13orf15

TAU:F.000008
type: UnificationXref
id: TAU:F-000008
db: Spike DB

BCL6
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#604

Sestrins.family
type: Protein
data source: Spike
member physical entity: SESN1
member physical entity: SESN2
member physical entity: SESN3
xref: ELK:F.329932

TAU:F.000001
type: UnificationXref
id: TAU:F-000001
db: Spike DB

TAU:F.000006
type: UnificationXref
id: TAU:F-000006
db: Spike DB

CASP10
type: Protein
entity reference: CASP10

http://www.ncbi.nlm.nih.gov/#94241
type: UnificationXref
id: 94241
db: Entrez Gene

PADI4_RNA
type: RnaRegion
entity reference: PADI4

21217645
type: PublicationXref
id: 21217645
title: miR-605 joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress
db: PubMed

BIRC2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#329

TRAF4_DNA
type: DnaRegion
entity reference: TRAF4

.CASP8.PROMOTES.CASP3.
type: Catalysis
controlled: Proteolytic.Processing.P.CASP8.CASP3
data source: Spike
controller: CASP8
xref: 9765224
xref: 11437602
control type: ACTIVATION

http://www.ncbi.nlm.nih.gov/#57103
type: UnificationXref
id: 57103
db: Entrez Gene

8967952
type: PublicationXref
id: 8967952
title: NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain
db: PubMed

9545235
type: PublicationXref
id: 9545235
title: IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
db: PubMed

14530260
type: PublicationXref
id: 14530260
title: Replication factor C clamp loader subunit arrangement within the circular pentamer and its attachment points to proliferating cell nuclear antigen
db: PubMed

.TP53.PROMOTES.MDM2.
type: TemplateReactionRegulation
controller: TP53
xref: 20624280
xref: 9260156
xref: 15838523
xref: 11328884
controlled: Transcription.Regulation.P.TP53.MDM2
data source: Spike
control type: ACTIVATION

PMAIP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5366

BBC3_DNA
type: DnaRegion
entity reference: BBC3

LRDD
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#55367

E2F1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1869

DDB2_DNA
type: DnaRegion
entity reference: DDB2

.TP53.PROMOTES.APAF1.
type: TemplateReactionRegulation
controller: TP53
xref: 11559530
xref: 11389439
xref: 11423996
controlled: Transcription.Regulation.P.TP53.APAF1
data source: Spike
control type: ACTIVATION

11389439
type: PublicationXref
id: 11389439
title: Apaf-1 is a transcriptional target for E2F and p53
db: PubMed

HSP90AB1
type: Protein
entity reference: HSP90AB1

ELK:F.329932
type: UnificationXref
id: ELK:F-329932
db: Spike DB

MIR125B2
type: Protein
entity reference: MIR125B2

http://www.ncbi.nlm.nih.gov/#23569
type: UnificationXref
id: 23569
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#22985
type: UnificationXref
id: 22985
db: Entrez Gene

CCND1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#595

E2F1-3.family
type: Protein
data source: Spike
xref: TAU:F.000001

DDB2
type: Protein
entity reference: DDB2

11328884
type: PublicationXref
id: 11328884
title: Binding to the naturally occurring double p53 binding site of the Mdm2 promoter alleviates the requirement for p53 C-terminal activation
db: PubMed

.TP53.PROMOTES.CASP6.
type: TemplateReactionRegulation
controller: TP53
xref: 12089322
xref: 18431400
controlled: Transcription.Regulation.P.TP53.CASP6
data source: Spike
control type: ACTIVATION

PRC1
type: Protein
entity reference: PRC1

9488720
type: PublicationXref
id: 9488720
title: Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex
db: PubMed

PTEN_RNA
type: RnaRegion
entity reference: PTEN

http://www.ncbi.nlm.nih.gov/#28984
type: UnificationXref
id: 28984
db: Entrez Gene

21163364
type: PublicationXref
id: 21163364
title: Dose-dependent mutual regulation between Wip1 and p53 following UVC irradiation
db: PubMed

8681376
type: PublicationXref
id: 8681376
title: Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
db: PubMed

.CDKN1A.INHIBITS.Complex.CycA.Cdk2....
type: Catalysis
controlled: Physical.Interaction.I.CDKN1A.CycA.Cdk2
data source: Spike
controller: CDKN1A
xref: 12383116
control type: INHIBITION

CDKN2A_RNA
type: RnaRegion
entity reference: CDKN2A

FBXW7_RNA
type: RnaRegion
entity reference: FBXW7

.ATR.PROMOTES.TP53.
type: Catalysis
controlled: Phosphorylation.P.ATR.TP53
data source: Spike
controller: ATR
xref: 9733515
xref: 9733514
xref: 17272272
xref: 9843217
control type: ACTIVATION

http://www.ncbi.nlm.nih.gov/#406912
type: UnificationXref
id: 406912
db: Entrez Gene

PCNA_DNA
type: DnaRegion
entity reference: PCNA

http://www.ncbi.nlm.nih.gov/#406911
type: UnificationXref
id: 406911
db: Entrez Gene

Translation
type: MolecularInteraction
participant: ATF3_RNA
participant: ATF3

ATF2
type: Protein
entity reference: ATF2

TP53INP1_DNA
type: DnaRegion
entity reference: TP53INP1

14688482
type: PublicationXref
id: 14688482
title: Caspase 10 levels are increased following DNA damage in a p53-dependent manner
db: PubMed

TP53INP1_RNA
type: RnaRegion
entity reference: TP53INP1

12209975
type: PublicationXref
id: 12209975
title: p53 status correlates with the differential expression of the DNA mismatch repair protein MSH2 in non-small cell lung carcinoma
db: PubMed

16774833
type: PublicationXref
id: 16774833
title: The ATM-mediated DNA-damage response: taking shape
db: PubMed

12944906
type: PublicationXref
id: 12944906
title: Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53
db: PubMed

.Family.H4....PROMOTES.TP53BP1.
type: Catalysis
controlled: Physical.Interaction.P.H4.TP53BP1
data source: Spike
controller: H4.family
xref: 19218832
xref: 18296440
control type: ACTIVATION

LRDD_RNA
type: RnaRegion
entity reference: LRDD

.FASLG.PROMOTES.FAS.
type: Catalysis
controlled: Physical.Interaction.P.FASLG.FAS
data source: Spike
controller: FASLG
xref: 9228058
xref: 9126929
control type: ACTIVATION

PMS2_RNA
type: RnaRegion
entity reference: PMS2

11283254
type: PublicationXref
id: 11283254
title: Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress
db: PubMed

ERCC6
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2074

APAF1_inactive
type: Protein
entity reference: APAF1

SIRT1
type: Protein
entity reference: SIRT1

CCNG1_RNA
type: RnaRegion
entity reference: CCNG1

Translation
type: MolecularInteraction
participant: BAX_RNA
participant: BAX

PCNA
type: Protein
entity reference: PCNA

BBC3_RNA
type: RnaRegion
entity reference: BBC3

.WRAP53.PROMOTES.TP53.
type: Catalysis
controlled: mRNA.stability.P.WRAP53.TP53
data source: Spike
controller: WRAP53
xref: 19250907
xref: 19918835
xref: 19571673
control type: ACTIVATION

PPM1D_DNA
type: DnaRegion
entity reference: PPM1D

TRAF4_RNA
type: RnaRegion
entity reference: TRAF4

BCL2
type: Protein
entity reference: BCL2

MSH2_DNA
type: DnaRegion
entity reference: MSH2

10669755
type: PublicationXref
id: 10669755
title: Arrest of G(1)-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcription
db: PubMed

FBXW7_DNA
type: DnaRegion
entity reference: FBXW7

.MIR125B2.INHIBITS.TP53.
type: Catalysis
controlled: mRNA.stability.I.MIR125B2.TP53
data source: Spike
controller: MIR125B2
xref: 21741842
xref: 20542001
control type: INHIBITION

LRDD
type: Protein
entity reference: LRDD

http://www.ncbi.nlm.nih.gov/#8493
type: UnificationXref
id: 8493
db: Entrez Gene

IER3
type: Protein
entity reference: IER3

H4.family
type: Protein
data source: Spike
xref: ELK:F.000029

.TP53.INHIBITS.RAD51.
type: TemplateReactionRegulation
controller: TP53
xref: 16322760
controlled: Transcription.Regulation.I.TP53.RAD51
data source: Spike
control type: INHIBITION

.TP53.INHIBITS.CDC25C.
type: TemplateReactionRegulation
controller: TP53
xref: 18431400
controlled: Transcription.Regulation.I.TP53.CDC25C
data source: Spike
control type: INHIBITION

19118006
type: PublicationXref
id: 19118006
title: Tumor protein 53-induced nuclear protein 1 is a major mediator of p53 antioxidant function
db: PubMed

CASP9
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#842

Translation
type: MolecularInteraction
participant: MDM2_inactive
participant: MDM2_RNA

.E2F1.PROMOTES.PPM1D.
type: TemplateReactionRegulation
controller: E2F1
xref: 16912047
controlled: Transcription.Regulation.P.E2F1.PPM1D
data source: Spike
control type: ACTIVATION

.RFWD2.INHIBITS.TP53.
type: Catalysis
controlled: Ubiquitination.I.RFWD2.TP53
data source: Spike
controller: RFWD2
xref: 15492238
control type: INHIBITION

http://www.ncbi.nlm.nih.gov/#55367
type: UnificationXref
id: 55367
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#143686
type: UnificationXref
id: 143686
db: Entrez Gene

19555669
type: PublicationXref
id: 19555669
title: Transcriptional down-regulation of Bcl-2 by vinorelbine: identification of a novel binding site of p53 on Bcl-2 promoter
db: PubMed

BAX_DNA
type: DnaRegion
entity reference: BAX

GTSE1
type: Protein
entity reference: GTSE1

PMS2_DNA
type: DnaRegion
entity reference: PMS2

TAU:F.329942
type: UnificationXref
id: TAU:F-329942
db: Spike DB

16839880
type: PublicationXref
id: 16839880
title: TIGAR, a p53-inducible regulator of glycolysis and apoptosis
db: PubMed

C13orf15
type: Protein
entity reference: C13orf15

TRIM22
type: Protein
entity reference: TRIM22

BBC3
type: Protein
entity reference: BBC3

http://www.ncbi.nlm.nih.gov/#1958
type: UnificationXref
id: 1958
db: Entrez Gene

MSH2_RNA
type: RnaRegion
entity reference: MSH2

Translation
type: MolecularInteraction
participant: Sestrins.family
participant: Sestrins.family_RNA

Translation
type: MolecularInteraction
participant: DUSP5_RNA
participant: DUSP5

FAS
type: Protein
entity reference: FAS

16249378
type: PublicationXref
id: 16249378
title: BCL6 is regulated by p53 through a response element frequently disrupted in B-cell non-Hodgkin's lymphoma
db: PubMed

12690110
type: PublicationXref
id: 12690110
title: p21Cip1 gene expression is modulated by Egr1: a novel regulatory mechanism involved in the resveratrol antiproliferative effect
db: PubMed

.TP53.PROMOTES.BCL6.
type: TemplateReactionRegulation
controller: TP53
xref: 16249378
controlled: Transcription.Regulation.P.TP53.BCL6
data source: Spike
control type: ACTIVATION

19250907
type: PublicationXref
id: 19250907
title: Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage
db: PubMed

Translation
type: MolecularInteraction
participant: PADI4_RNA
participant: PADI4

FASLG
type: Protein
entity reference: FASLG

10781582
type: PublicationXref
id: 10781582
title: ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation
db: PubMed

TP53_RNA
type: RnaRegion
entity reference: TP53

XIAP
type: Protein
entity reference: XIAP

XPC
type: Protein
entity reference: XPC