In vivo recruitment of XPC to UV-induced cyclobutane pyrimidine dimers by the DDB2 gene product
A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain
Polymorphic TP53BP1 and TP53 gene interactions associated with risk of squamous cell carcinoma of the head and neck
MKP-1 represses JNK-mediated apoptosis via NF-kappa B regulation
Negative regulation of bcl-2 expression by p53 in hematopoietic cells
Differential regulation of the p21/WAF-1 and mdm2 genes after high-dose UV irradiation: p53-dependent and p53-independent regulation of the mdm2 gene
Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner
Expression of a homeostatic regulator, Wip1 (wild-type p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation
The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis
Gadd45a contributes to p53 stabilization in response to DNA damage
Stress-specific response of the p53-Mdm2 feedback loop
TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity
Induction of ATF3 by ionizing radiation is mediated via a signaling pathway that includes ATM, Nibrin1, stress-induced MAPkinases and ATF-2
PP2A regulates ionizing radiation-induced apoptosis through Ser46 phosphorylation of p53
Identification of the mismatch repair genes PMS2 and MLH1 as p53 target genes by using serial analysis of binding elements
The cell cycle-regulated protein human GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function
p53AIP1 regulates the mitochondrial apoptotic pathway
Cyclin-dependent kinase inhibitors CIP1 (p21) and KIP1 (p27) in ovarian cancer
The phosphatase MKP1 is a transcriptional target of p53 involved in cell cycle regulation
Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways
Histone modifications: crucial elements for damage response and chromatin restoration
PUMA mediates the apoptotic response to p53 in colorectal cancer cells
Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double strand breaks
Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation
DNA damage-induced MDMX degradation is mediated by MDM2
Apoptotic threshold is lowered by p53 transactivation of caspase-6
Characterization of Fas (Apo-1, CD95)-Fas ligand interaction
X-linked IAP is a direct inhibitor of cell-death proteases
IAP family proteins--suppressors of apoptosis
SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription
p53 promotes selection for Fas-mediated apoptotic resistance
A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein
The C terminus of p53 binds the N-terminal domain of MDM2
The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death
Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family
ATM activates p53 by regulating MDM2 oligomerization and E3 processivity
The Bcl2 family: regulators of the cellular life-or-death switch
dapk1, encoding an activator of a p19ARF-p53-mediated apoptotic checkpoint, is a transcription target of p53
p53 Binds and activates the xeroderma pigmentosum DDB2 gene in humans but not mice
E2F-dependent induction of p14ARF during cell cycle re-entry in human T cells
A CAF-1-PCNA-mediated chromatin assembly pathway triggered by sensing DNA damage
Is there a code embedded in proteins that is based on post-translational modifications?
Preferential dimethylation of histone H4 lysine 20 by Suv4-20
COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas
Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis
ATM associates with and phosphorylates p53: mapping the region of interaction
Expression of p53R2, newly p53 target in oral normal epithelium, epithelial dysplasia and squamous cell carcinoma.
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
Massively regulated genes: the example of TP53
PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition
Rb regulates fate choice and lineage commitment in vivo
ATM-mediated phosphorylation activates the tumor-suppressive function of B56-PP2A
p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs
Histone deimination antagonizes arginine methylation
p53 modulates homologous recombination by transcriptional regulation of the RAD51 gene
A chaperone-dependent GSK3beta transitional intermediate mediates activation-loop autophosphorylation
Identification of amino acid residues important for ligand binding to Fas
Connecting proliferation and apoptosis in development and disease
Cloning, chromosome mapping and functional characterization of a human homologue of murine gtse-1 (B99) gene
CSB protein is (a direct target of HIF-1 and) a critical mediator of the hypoxic response
P53-dependent expression of the stress-induced protein (SIP)
Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit
The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites
PRAK is essential for ras-induced senescence and tumor suppression
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
Efficient activation of p53 pathway in A549 cells exposed to L2, a novel compound targeting p53-MDM2 interaction
DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1
DNA damage induced p53 downregulates Cdc20 by direct binding to its promoter causing chromatin remodeling
Regulation of protein Citrullination through p53/PADI4 network in DNA damage response
Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity
E2F1 modulates p38 MAPK phosphorylation via transcriptional regulation of ASK1 and Wip1
Human PAD4 regulates histone arginine methylation levels via demethylimination
[W206R]-procaspase 3: an inactivatable substrate for caspase 8
Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway
Transcriptional regulation of the PCNA promoter by p53
PUMA, a novel proapoptotic gene, is induced by p53
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53
A single BIR domain of XIAP sufficient for inhibiting caspases
Cockayne syndrome B protein (CSB): linking p53, HIF-1 and p300 to robustness, lifespan, cancer and cell fate decisions
The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
Enhanced phosphorylation of p53 by ATM in response to DNA damage
Transcriptional control of human p53-regulated genes
Pro-proliferative FoxM1 is a target of p53-mediated repression
APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis
Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD
Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways
xeroderma pigmentosum complementation group E
Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence
The p53 pathway: positive and negative feedback loops
Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage.
A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55
Computer-assisted identification of cell cycle-related genes: new targets for E2F transcription factors.
Identification and characterization of the cytoplasmic protein TRAF4 as a p53 regulated pro-apoptotic gene
hCDC4b, a regulator of cyclin E, as a direct transcriptional target of p53
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
Highly potent p21(WAF1)-derived peptide inhibitors of CDK-mediated pRb phosphorylation: delineation and structural insight into their interactions with cyclin A
IAP proteins: blocking the road to death's door
Gadd45a, a p53- and BRCA1-regulated stress protein, in cellular response to DNA damage
Pro-caspase-3 is a major physiologic target of caspase-8
Identification of PRC1 as the p53 target gene uncovers a novel function of p53 in the regulation of cytokinesis
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage
Regulation of life and death by the zinc finger transcription factor Egr-1
p21/CDKN1A mediates negative regulation of transcription by p53
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
Identification of a p53-dependent negative response element in the bcl-2 gene
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
BID regulation by p53 contributes to chemosensitivity
Chromatin dynamics coupled to DNA repair
miR-605 joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress
NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain
IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
Replication factor C clamp loader subunit arrangement within the circular pentamer and its attachment points to proliferating cell nuclear antigen
Apaf-1 is a transcriptional target for E2F and p53
Binding to the naturally occurring double p53 binding site of the Mdm2 promoter alleviates the requirement for p53 C-terminal activation
Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex
Dose-dependent mutual regulation between Wip1 and p53 following UVC irradiation
Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
Caspase 10 levels are increased following DNA damage in a p53-dependent manner
p53 status correlates with the differential expression of the DNA mismatch repair protein MSH2 in non-small cell lung carcinoma
The ATM-mediated DNA-damage response: taking shape
Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53
Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress
Arrest of G(1)-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcription
Tumor protein 53-induced nuclear protein 1 is a major mediator of p53 antioxidant function
Transcriptional down-regulation of Bcl-2 by vinorelbine: identification of a novel binding site of p53 on Bcl-2 promoter
TIGAR, a p53-inducible regulator of glycolysis and apoptosis
BCL6 is regulated by p53 through a response element frequently disrupted in B-cell non-Hodgkin's lymphoma
p21Cip1 gene expression is modulated by Egr1: a novel regulatory mechanism involved in the resveratrol antiproliferative effect
Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage
ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation