MAP1LC3B_inactive
type: Protein
entity reference: MAP1LC3B

5'-AMP-activated protein kinase
type: Complex
data source: Spike
display name: AMPK.complex

18372248
type: PublicationXref
id: 18372248
db: PubMed
title: Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation

http://www.ncbi.nlm.nih.gov/#9706
type: UnificationXref
id: 9706
db: Entrez Gene

.Family.Ras.GTPases....PROMOTES.RAF1.
type: Catalysis
controller: Ras GTPases.family
data source: Spike
control type: ACTIVATION
controlled: Physical.Interaction.P.Ras.GTPases.RAF1
xref: 9395281

http://www.ncbi.nlm.nih.gov/#60673
type: UnificationXref
id: 60673
db: Entrez Gene

20513426
type: PublicationXref
id: 20513426
db: PubMed
title: Negative regulation of Vps34 by Cdk mediated phosphorylation

MTMR3
type: Protein
entity reference: MTMR3

Calpains.family
type: Protein
data source: Spike
xref: CEN:F.329890

11604401
type: PublicationXref
id: 11604401
db: PubMed
title: Identification of a C-terminal region that regulates mitogen-activated protein kinase kinase-1 cytoplasmic localization and ERK activation

http://www.ncbi.nlm.nih.gov/#8655
type: UnificationXref
id: 8655
db: Entrez Gene

MKK1/2.family_inactive
type: Protein

12600311
type: PublicationXref
id: 12600311
db: PubMed
title: The molecular motor toolbox for intracellular transport

19590496
type: PublicationXref
id: 19590496
db: PubMed
title: Control of autophagy initiation by phosphoinositide 3-phosphatase Jumpy

BCL2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#596

hVps34 Complex I.complex_inactive
type: Protein

.CAMKK2.PROMOTES.Complex.AMPK...(PRKAG1).
type: Catalysis
controller: CAMKK2
data source: Spike
control type: ACTIVATION
controlled: Phosphorylation.P.CAMKK2.AMPK
xref: 16054096
xref: 17244528

ATG12
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9140

1381507
type: PublicationXref
id: 1381507
db: PubMed
title: Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product

.ATM.PROMOTES.STK11.
type: Catalysis
controller: ATM
data source: Spike
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.STK11
xref: 12234250

DAPK1
type: Protein
entity reference: DAPK1

.SH3GLB1.PROMOTES.UVRAG.
type: Catalysis
controller: SH3GLB1
data source: Spike
control type: ACTIVATION
controlled: Physical.Interaction.P.SH3GLB1.UVRAG
xref: 18032918

12473658
type: PublicationXref
id: 12473658
db: PubMed
title: The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A

15854902
type: PublicationXref
id: 15854902
db: PubMed
title: Rheb binds and regulates the mTOR kinase

.MTOR.PROMOTES.DAP.
type: Catalysis
controller: MTOR
data source: Spike
control type: ACTIVATION
controlled: Phosphorylation.P.MTOR.DAP
xref: 20537536

SH3GLB1
type: Protein
entity reference: SH3GLB1

PhysicalInteraction [Complex MT {} -- Complex dynein {DYNLL1} ]
type: MolecularInteraction
xref: 12600311
xref: 8448036
participant: microtubules
participant: dynein

.Complex.hVps34.Complex.I..ATG14,.BECN1,.PIK3C3,.PIK3R4..PROMOTES.PI3P.
type: Catalysis
controller: Vps34Class III PI3K complex
data source: Spike
control type: ACTIVATION
controlled: Phosphorylation.P.hVps34.Complex.I.PI3P
xref: 19270693
xref: 19270696
xref: 16390869

19346248
type: PublicationXref
id: 19346248
db: PubMed
title: Mammalian Target of Rapamycin Complex 1 (mTORC1) Activity Is Associated with Phosphorylation of Raptor by mTOR

.BNIP3.INHIBITS.BCL2L1.
type: Catalysis
controller: BNIP3
data source: Spike
control type: INHIBITION
controlled: Physical.Interaction.I.BNIP3.BCL2L1
xref: 10625696

Vps34Class III PI3K complex
type: Complex
data source: Spike
component: ATG14
component: PIK3R4
component: PIK3C3
component: BECN1
display name: hVps34 Complex I.complex

AKT1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#207

FOXO1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2308

HMGB1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3146

FOXO1
type: Protein
entity reference: FOXO1

21068542
type: PublicationXref
id: 21068542
db: PubMed
title: Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy

15694340
type: PublicationXref
id: 15694340
db: PubMed
title: Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

16093354
type: PublicationXref
id: 16093354
db: PubMed
title: Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding

http://www.ncbi.nlm.nih.gov/#8678
type: UnificationXref
id: 8678
db: Entrez Gene

18842334
type: PublicationXref
id: 18842334
db: PubMed
title: Caspase-mediated cleavage of ATG6/Beclin-1 links apoptosis to autophagy in HeLa cells

http://www.ncbi.nlm.nih.gov/#5289
type: UnificationXref
id: 5289
db: Entrez Gene

MCL1
type: Protein
entity reference: MCL1

8157000
type: PublicationXref
id: 8157000
db: PubMed
title: Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1

.Complex.Atg5/12..ATG12,.ATG5..PROMOTES.ATG16L1.
type: Catalysis
controller: Atg5-Atg12 conjugation
data source: Spike
control type: ACTIVATION
controlled: Physical.Interaction.P.Atg5/12.ATG16L1
xref: 11265251
xref: 10406794
xref: 12665549

ATG12
type: Protein
entity reference: ATG12

16179260
type: PublicationXref
id: 16179260
db: PubMed
title: Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

ATG16L1_inactive
type: Protein
entity reference: ATG16L1

GABARAP-L2/GATE-16 form II
type: Complex
data source: Spike
component: GABARAPL2
component: PE
display name: GATE-16-PE.complex

http://www.ncbi.nlm.nih.gov/#84335
type: UnificationXref
id: 84335
db: Entrez Gene

16998475
type: PublicationXref
id: 16998475
db: PubMed
title: Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis

.MTOR.PROMOTES.MTOR.
type: Catalysis
controller: MTOR
data source: Spike
control type: ACTIVATION
controlled: Phosphorylation.P.MTOR.MTOR
xref: 20022946

17891140
type: PublicationXref
id: 17891140
db: PubMed
title: Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis

DAPK3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1613

.ULK1.PROMOTES.RB1CC1.
type: Catalysis
controller: ULK1
data source: Spike
control type: ACTIVATION
controlled: Phosphorylation.P.ULK1.RB1CC1
xref: 19225151

http://www.ncbi.nlm.nih.gov/#57521
type: UnificationXref
id: 57521
db: Entrez Gene

.Family.Caspases,.effector....INHIBITS.BECN1.
type: Catalysis
controller: Caspases, effector.family
data source: Spike
control type: INHIBITION
controlled: Proteolytic.Processing.I.Caspases,.effector.BECN1
xref: 21121091
xref: 21364619
xref: 18842334
xref: 19713971

http://www.ncbi.nlm.nih.gov/#9140
type: UnificationXref
id: 9140
db: Entrez Gene

BCL2L1
type: Protein
entity reference: BCL2L1

http://www.ncbi.nlm.nih.gov/#9711
type: UnificationXref
id: 9711
db: Entrez Gene

19258318
type: PublicationXref
id: 19258318
db: PubMed
title: ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

RLC (nonmuscle).family_inactive
type: Protein

PMAIP1
type: Protein
entity reference: PMAIP1

18725538
type: PublicationXref
id: 18725538
db: PubMed
title: Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

.ATG4B.INHIBITS.Complex.GABARAP.PE..GABARAP.(GABARAP).
type: Catalysis
controller: ATG4B
data source: Spike
control type: INHIBITION
controlled: Proteolytic.Processing.I.ATG4B.GABARAP.PE
xref: 15187094
xref: 14530254

CDK1
type: Protein
entity reference: CDK1

http://www.ncbi.nlm.nih.gov/#23770
type: UnificationXref
id: 23770
db: Entrez Gene

ATG5_inactive
type: Protein
entity reference: ATG5

9580671
type: PublicationXref
id: 9580671
db: PubMed
title: Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

PE
type: SmallMoleculeReference
xref: http://www.ebi.ac.uk/chebi/#16038

20010695
type: PublicationXref
id: 20010695
db: PubMed
title: Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1

PhysicalInteraction [MTOR -- RHEB ]
type: MolecularInteraction
xref: 15854902
xref: 16098514
participant: RHEB
participant: MTOR

MCL1_inactive
type: Protein
entity reference: MCL1

WIPI1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#55062

19270693
type: PublicationXref
id: 19270693
db: PubMed
title: Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex

.KIAA0226.INHIBITS.BECN1.
type: Catalysis
controller: KIAA0226
data source: Spike
control type: INHIBITION
controlled: Physical.Interaction.I.KIAA0226.BECN1
xref: 19270693
xref: 19270696

19270696
type: PublicationXref
id: 19270696
db: PubMed
title: Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

PI3P
type: SmallMoleculeReference
xref: http://www.ebi.ac.uk/chebi/#26034

http://www.ncbi.nlm.nih.gov/#664
type: UnificationXref
id: 664
db: Entrez Gene

.ATG4B.PROMOTES.GABARAP.
type: Catalysis
controller: ATG4B
data source: Spike
control type: ACTIVATION
controlled: Proteolytic.Processing.P.ATG4B.GABARAP
xref: 15187094
xref: 14530254

.Complex.hVps34.Complex.II..BECN1,.PIK3C3,.UVRAG,.PIK3R4..PROMOTES.ATG9A.
type: Catalysis
controller: Vps34 Class III PI3K complex with UVRAG
data source: Spike
control type: ACTIVATION
controlled: Other.P.hVps34.Complex.II.ATG9A
xref: 21068542

Caspases, effector.family
type: Protein
data source: Spike
xref: WSC:F.000006

http://www.ncbi.nlm.nih.gov/#79065
type: UnificationXref
id: 79065
db: Entrez Gene

PIK3R4
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#30849

PINK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#65018

DAPK3
type: Protein
entity reference: DAPK3

12665549
type: PublicationXref
id: 12665549
db: PubMed
title: Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate

20404487
type: PublicationXref
id: 20404487
db: PubMed
title: GABARAPL1 (GEC1) associates with autophagic vesicles

.Family.ERK....INHIBITS.TSC2.
type: Catalysis
controller: ERK.family
data source: Spike
control type: INHIBITION
controlled: Phosphorylation.I.ERK.TSC2
xref: 15851026
xref: 12867426
xref: 16244323

11256955
type: PublicationXref
id: 11256955
db: PubMed
title: Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi

.DAPK1.PROMOTES.DAPK3.
type: Catalysis
controller: DAPK1
data source: Spike
control type: ACTIVATION
controlled: Phosphorylation.P.DAPK1.DAPK3
xref: 15367680

.RAF1.PROMOTES.Family.MKK1/2...(MAP2K1).
type: Catalysis
controller: RAF1
data source: Spike
control type: ACTIVATION
controlled: Phosphorylation.P.RAF1.MKK1/2
xref: 8157000
xref: 8621729
xref: 16093354
xref: 8394352
xref: 11604401
xref: 7731720

FAM48A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#55578

.Family.RSK1/2....PROMOTES.RPTOR.
type: Catalysis
controller: RSK1/2.family
data source: Spike
control type: ACTIVATION
controlled: Phosphorylation.P.RSK1/2.RPTOR
xref: 18722121

http://www.ncbi.nlm.nih.gov/#11345
type: UnificationXref
id: 11345
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#8408
type: UnificationXref
id: 8408
db: Entrez Gene

SH3GLB1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#51100

http://www.ebi.ac.uk/chebi/#26034
type: UnificationXref
id: 26034
db: ChEBI

ATG3
type: Protein
entity reference: ATG3

.AKT1.INHIBITS.RAF1.
type: Catalysis
controller: AKT1
data source: Spike
control type: INHIBITION
controlled: Phosphorylation.I.AKT1.RAF1
xref: 10618391
xref: 12048182
xref: 10576742

ULK complex.complex
type: Complex
data source: Spike
component: ULK2
component: C12orf44
component: RB1CC1
component: ATG13
component: ULK1

ATM
type: Protein
entity reference: ATM

.UVRAG.PROMOTES.SH3GLB1.
type: Catalysis
controller: UVRAG
data source: Spike
control type: ACTIVATION
controlled: Physical.Interaction.P.UVRAG.SH3GLB1
xref: 17891140

.AKT1.INHIBITS.TSC2.
type: Catalysis
controller: AKT1
data source: Spike
control type: INHIBITION
controlled: Phosphorylation.I.AKT1.TSC2
xref: 16288292
xref: 15661536

RHEB
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6009

RB1CC1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9821

ATG13_inactive
type: Protein
entity reference: ATG13

BECN1_inactive
type: Protein
entity reference: BECN1

http://www.ncbi.nlm.nih.gov/#11337
type: UnificationXref
id: 11337
db: Entrez Gene

18032918
type: PublicationXref
id: 18032918
db: PubMed
title: BARgaining membranes for autophagosome formation: Regulation of autophagy and tumorigenesis by Bif-1/Endophilin B1

http://www.ncbi.nlm.nih.gov/#9821
type: UnificationXref
id: 9821
db: Entrez Gene

7688567
type: PublicationXref
id: 7688567
db: PubMed
title: Regulation of an epitope-tagged recombinant Rsk-1 S6 kinase by phorbol ester and erk/MAP kinase

18604198
type: PublicationXref
id: 18604198
db: PubMed
title: Regulation of TORC1 by Rag GTPases in nutrient response

BCL2L1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#598

7731720
type: PublicationXref
id: 7731720
db: PubMed
title: B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222

.ULK1.PROMOTES.DAPK3.
type: Catalysis
controller: ULK1
data source: Spike
control type: ACTIVATION
controlled: Physical.Interaction.P.ULK1.DAPK3
xref: 21169990

GABARAP form II
type: Complex
data source: Spike
component: GABARAP
display name: GABARAP-PE.complex

19838173
type: PublicationXref
id: 19838173
db: PubMed
title: FLIP-mediated autophagy regulation in cell death control

STK11
type: Protein
entity reference: STK11

AMBRA1_inactive
type: Protein
entity reference: AMBRA1

19893488
type: PublicationXref
id: 19893488
db: PubMed
title: Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP

RAF1
type: Protein
entity reference: RAF1

15187094
type: PublicationXref
id: 15187094
db: PubMed
title: HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates

19172397
type: PublicationXref
id: 19172397
db: PubMed
title: The paradox of autophagy and its implication in cancer etiology and therapy

STK11_inactive
type: Protein
entity reference: STK11

LC3 (Atg8/MAP1LC3B) -PE conjugation
type: Complex
data source: Spike
component: MAP1LC3B
component: PE
display name: LC3-PE.complex

http://www.ncbi.nlm.nih.gov/#7189
type: UnificationXref
id: 7189
db: Entrez Gene

ATG9A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#79065

ATG13
type: Protein
entity reference: ATG13

MTOR
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2475

19713971
type: PublicationXref
id: 19713971
db: PubMed
title: Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL

Homo sapiens
type: BioSource
xref: 9606

ATG16L1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#55054

RAG.family
type: Protein
data source: Spike
xref: WSC:F.000003

.MCL1.INHIBITS.BECN1.
type: Catalysis
controller: MCL1
data source: Spike
control type: INHIBITION
controlled: Physical.Interaction.I.MCL1.BECN1
xref: 21139567
xref: 21353614

ATG9A_inactive
type: Protein
entity reference: ATG9A

http://www.ncbi.nlm.nih.gov/#64422
type: UnificationXref
id: 64422
db: Entrez Gene

.STK11.PROMOTES.Complex.AMPK...(PRKAG1).
type: Catalysis
controller: STK11
data source: Spike
control type: ACTIVATION
controlled: Phosphorylation.P.STK11.AMPK
xref: 15509864
xref: 15661536

10995454
type: PublicationXref
id: 10995454
db: PubMed
title: Tor-mediated induction of autophagy via an Apg1 protein kinase complex

BCL2_inactive
type: Protein
entity reference: BCL2

DAP
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1611

FAM48A
type: Protein
entity reference: FAM48A

GABARAPL2_inactive
type: Protein
entity reference: GABARAPL2

http://www.ncbi.nlm.nih.gov/#10533
type: UnificationXref
id: 10533
db: Entrez Gene

10406794
type: PublicationXref
id: 10406794
db: PubMed
title: Apg16p is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway

18075516
type: PublicationXref
id: 18075516
db: PubMed
title: Kinases meet at TSC

GABARAPL1
type: Protein
entity reference: GABARAPL1

.MTOR.INHIBITS.ULK1.
type: Catalysis
controller: MTOR
data source: Spike
control type: INHIBITION
controlled: Indirect.I.MTOR.ULK1
xref: 17595159
xref: 10995454
xref: 21258367

TAU:F.000011
type: UnificationXref
id: TAU:F-000011
db: Spike DB

TSC2_inactive
type: Protein
entity reference: TSC2

http://www.ncbi.nlm.nih.gov/#64419
type: UnificationXref
id: 64419
db: Entrez Gene

TAU:F.000019
type: UnificationXref
id: TAU:F-000019
db: Spike DB

http://www.ncbi.nlm.nih.gov/#207
type: UnificationXref
id: 207
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#26100
type: UnificationXref
id: 26100
db: Entrez Gene

.Complex.ULK.complex..ULK2,.ATG13,.ULK1,.RB1CC1,.C12orf44..PROMOTES.Complex.hVps34.Complex.I..ATG14,.BECN1,.PIK3C3,.PIK3R4.(PIK3C3).
type: Catalysis
controller: ULK complex.complex
data source: Spike
control type: ACTIVATION
controlled: Indirect.P.ULK.complex.hVps34.Complex.I
xref: 17595159

.ATG13.PROMOTES.RB1CC1.
type: Catalysis
controller: ATG13
data source: Spike
control type: ACTIVATION
controlled: Physical.Interaction.P.ATG13.RB1CC1
xref: 19225151
xref: 19211835

.ATG4B.PROMOTES.GABARAPL1.
type: Catalysis
controller: ATG4B
data source: Spike
control type: ACTIVATION
controlled: mRNA.stability.P.ATG4B.GABARAPL1
xref: 20404487
xref: 14530254

ULK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8408

19287211
type: PublicationXref
id: 19287211
db: PubMed
title: A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy

18641390
type: PublicationXref
id: 18641390
db: PubMed
title: Bcl-xL and UVRAG cause a monomer-dimer switch in Beclin1

RPTOR
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#57521

CFLAR
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8837

15367680
type: PublicationXref
id: 15367680
db: PubMed
title: Death-associated protein kinase phosphorylates ZIP kinase, forming a unique kinase hierarchy to activate its cell death functions

WIPI1
type: Protein
entity reference: WIPI1

http://www.ncbi.nlm.nih.gov/#10645
type: UnificationXref
id: 10645
db: Entrez Gene

http://www.ebi.ac.uk/chebi/#16038
type: UnificationXref
id: 16038
db: ChEBI

PI3P_inactive
type: Protein

CISD2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#493856

ATG3_inactive
type: Protein
entity reference: ATG3

TAU:F.000020
type: UnificationXref
id: TAU:F-000020
db: Spike DB

ATG4B
type: Protein
entity reference: ATG4B

20543840
type: PublicationXref
id: 20543840
db: PubMed
title: Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

.BECN1.PROMOTES.PIK3C3.
type: Catalysis
controller: BECN1
data source: Spike
control type: ACTIVATION
controlled: Physical.Interaction.P.BECN1.PIK3C3
xref: 19172397

21139567
type: PublicationXref
id: 21139567
db: PubMed
title: MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner

TSC2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7249

ATG4A
type: Protein
entity reference: ATG4A

http://www.ncbi.nlm.nih.gov/#7405
type: UnificationXref
id: 7405
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#23192
type: UnificationXref
id: 23192
db: Entrez Gene

18936157
type: PublicationXref
id: 18936157
db: PubMed
title: Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism

.TSC2.INHIBITS.RHEB.
type: Catalysis
controller: TSC2
data source: Spike
control type: INHIBITION
controlled: Physical.Interaction.I.TSC2.RHEB
xref: 12771962
xref: 12869586

.FKBP8.INHIBITS.MTOR.
type: Catalysis
controller: FKBP8
data source: Spike
control type: INHIBITION
controlled: Physical.Interaction.I.FKBP8.MTOR
xref: 17991864

.AKT1S1.INHIBITS.RPTOR.
type: Catalysis
controller: AKT1S1
data source: Spike
control type: INHIBITION
controlled: Physical.Interaction.I.AKT1S1.RPTOR
xref: 18030348
xref: 17510057
xref: 17386266

.MTOR.INHIBITS.AKT1S1.
type: Catalysis
controller: MTOR
data source: Spike
control type: INHIBITION
controlled: Phosphorylation.I.MTOR.AKT1S1
xref: 18372248
xref: 17517883
xref: 18030348
xref: 17604271

http://www.ncbi.nlm.nih.gov/#9776
type: UnificationXref
id: 9776
db: Entrez Gene

12869586
type: PublicationXref
id: 12869586
db: PubMed
title: Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

BNIP3
type: Protein
entity reference: BNIP3

.BECN1.PROMOTES.BECN1.
type: Catalysis
controller: BECN1
data source: Spike
control type: ACTIVATION
controlled: Physical.Interaction.P.BECN1.BECN1
xref: 18641390

20537536
type: PublicationXref
id: 20537536
db: PubMed
title: DAP1, a novel substrate of mTOR, negatively regulates autophagy

ATM
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#472

MLST8
type: Protein
entity reference: MLST8

10625696
type: PublicationXref
id: 10625696
db: PubMed
title: BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites

Atg5-Atg12-Atg16
type: Complex
data source: Spike
component: ATG16L1
component: ATG5
component: ATG12
display name: Atg5/12/16.complex

http://www.ncbi.nlm.nih.gov/#1613
type: UnificationXref
id: 1613
db: Entrez Gene

UVRAG
type: Protein
entity reference: UVRAG

17589504
type: PublicationXref
id: 17589504
db: PubMed
title: Ambra1 regulates autophagy and development of the nervous system

http://www.ncbi.nlm.nih.gov/#53349
type: UnificationXref
id: 53349
db: Entrez Gene

http://www.ebi.ac.uk/chebi/#16027
type: UnificationXref
id: 16027
db: ChEBI

.ATG12.PROMOTES.ATG5.
type: Catalysis
controller: ATG12
data source: Spike
control type: ACTIVATION
controlled: Other.P.ATG12.ATG5
xref: 9759731
xref: 9852036
xref: 11265251

ATG5
type: Protein
entity reference: ATG5

10618391
type: PublicationXref
id: 10618391
db: PubMed
title: Analysis of receptor signaling pathways by mass spectrometry: identification of vav-2 as a substrate of the epidermal and platelet-derived growth factor receptors

.BNIP3.INHIBITS.BCL2.
type: Catalysis
controller: BNIP3
data source: Spike
control type: INHIBITION
controlled: Physical.Interaction.I.BNIP3.BCL2
xref: 10625696

http://www.ncbi.nlm.nih.gov/#836
type: UnificationXref
id: 836
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#65018
type: UnificationXref
id: 65018
db: Entrez Gene

CAMKK2_inactive
type: Protein
entity reference: CAMKK2

ATG7
type: Protein
entity reference: ATG7

ATG14
type: Protein
entity reference: ATG14

C12orf44
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#60673

.Family.ERK....PROMOTES.DAPK1.
type: Catalysis
controller: ERK.family
data source: Spike
control type: ACTIVATION
controlled: Phosphorylation.P.ERK.DAPK1
xref: 15616583

ATG5
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9474

11781833
type: PublicationXref
id: 11781833
db: PubMed
title: HeLa ZIP kinase induces diphosphorylation of myosin II regulatory light chain and reorganization of actin filaments in nonmuscle cells

15342917
type: PublicationXref
id: 15342917
db: PubMed
title: Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

BCL2L11
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#10018

http://www.ncbi.nlm.nih.gov/#1611
type: UnificationXref
id: 1611
db: Entrez Gene

BNIP3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#664

http://www.ncbi.nlm.nih.gov/#1612
type: UnificationXref
id: 1612
db: Entrez Gene

vVps34 Class III PI3K complex with Rubicon
type: Complex
data source: Spike
component: KIAA0226
component: PIK3R4
component: PIK3C3
component: BECN1
component: UVRAG
display name: hVPs34 Complex III.complex

.ATG4B.PROMOTES.GABARAPL2.
type: Catalysis
controller: ATG4B
data source: Spike
control type: ACTIVATION
controlled: Proteolytic.Processing.P.ATG4B.GABARAPL2
xref: 15187094
xref: 14530254

Ras GTPases.family
type: Protein
data source: Spike
xref: TAU:F.000019

.Complex.myosin.II..Family.RLC.(nonmuscle).....PROMOTES.ATG9A.
type: Catalysis
controller: myosin II
data source: Spike
control type: ACTIVATION
controlled: Other.P.myosin.II.ATG9A
xref: 21169990

12771962
type: PublicationXref
id: 12771962
db: PubMed
title: Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

16054096
type: PublicationXref
id: 16054096
db: PubMed
title: Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells

17510057
type: PublicationXref
id: 17510057
db: PubMed
title: PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding

http://www.ncbi.nlm.nih.gov/#4170
type: UnificationXref
id: 4170
db: Entrez Gene

9430630
type: PublicationXref
id: 9430630
db: PubMed
title: Bim: a novel member of the Bcl-2 family that promotes apoptosis

PhysicalInteraction [WIPI1 -- PI3P ]
type: MolecularInteraction
xref: 17618624
participant: WIPI1
participant: PI3P

.ULK2.UNKNOWN.ULK2.
type: Catalysis
controller: ULK2
data source: Spike
control type: ACTIVATION_UNKMECH
controlled: Phosphorylation.U.ULK2.ULK2
xref: 18936157

16799551
type: PublicationXref
id: 16799551
db: PubMed
title: Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG

http://www.ncbi.nlm.nih.gov/#6794
type: UnificationXref
id: 6794
db: Entrez Gene

ERK.family
type: Protein
data source: Spike
xref: TAU:F.000011

ZFYVE1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#53349

.BCL2L1.INHIBITS.BECN1.
type: Catalysis
controller: BCL2L1
data source: Spike
control type: INHIBITION
controlled: Physical.Interaction.I.BCL2L1.BECN1
xref: 17337444
xref: 9765397

.ATG4D.PROMOTES.GABARAPL1.
type: Catalysis
controller: ATG4D
data source: Spike
control type: ACTIVATION
controlled: Proteolytic.Processing.P.ATG4D.GABARAPL1
xref: 19549685

GABARAPL1_inactive
type: Protein
entity reference: GABARAPL1

.RPTOR.PROMOTES.MTOR.
type: Catalysis
controller: RPTOR
data source: Spike
control type: ACTIVATION
controlled: Physical.Interaction.P.RPTOR.MTOR
xref: 12150925

15096528
type: PublicationXref
id: 15096528
db: PubMed
title: ZIP kinase is responsible for the phosphorylation of myosin II and necessary for cell motility in mammalian fibroblasts

18030348
type: PublicationXref
id: 18030348
db: PubMed
title: PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis

.ULK1.PROMOTES.AMBRA1.
type: Catalysis
controller: ULK1
data source: Spike
control type: ACTIVATION
controlled: Phosphorylation.P.ULK1.AMBRA1
xref: 20921139

MTMR14
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#64419

21258367
type: PublicationXref
id: 21258367
db: PubMed
title: AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

http://www.ncbi.nlm.nih.gov/#596
type: UnificationXref
id: 596
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#5366
type: UnificationXref
id: 5366
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#598
type: UnificationXref
id: 598
db: Entrez Gene

19211835
type: PublicationXref
id: 19211835
db: PubMed
title: Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

.MTOR.PROMOTES.RPTOR.
type: Catalysis
controller: MTOR
data source: Spike
control type: ACTIVATION
controlled: Phosphorylation.P.MTOR.RPTOR
xref: 19346248

.ATG13.PROMOTES.ULK2.
type: Catalysis
controller: ATG13
data source: Spike
control type: ACTIVATION
controlled: Physical.Interaction.P.ATG13.ULK2
xref: 19225151

ATG16L1
type: Protein
entity reference: ATG16L1

http://www.ncbi.nlm.nih.gov/#23710
type: UnificationXref
id: 23710
db: Entrez Gene

Spike
type: Provenance

15509864
type: PublicationXref
id: 15509864
db: PubMed
title: The AMP-activated protein kinase pathway--new players upstream and downstream

.MTOR.INHIBITS.ATG13.
type: Catalysis
controller: MTOR
data source: Spike
control type: INHIBITION
controlled: Phosphorylation.I.MTOR.ATG13
xref: 19225151
xref: 19258318
xref: 19211835

AKT1S1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#84335

ATG9A
type: Protein
entity reference: ATG9A

GABARAP
type: Protein
entity reference: GABARAP

15611134
type: PublicationXref
id: 15611134
db: PubMed
title: Regulation of zipper-interacting protein kinase activity in vitro and in vivo by multisite phosphorylation

.CDK1.INHIBITS.PIK3C3.
type: Catalysis
controller: CDK1
data source: Spike
control type: INHIBITION
controlled: Phosphorylation.I.CDK1.PIK3C3
xref: 20513426

AKT1S1_inactive
type: Protein
entity reference: AKT1S1

SH3GLB1_inactive
type: Protein
entity reference: SH3GLB1

.ATG4B.INHIBITS.Complex.GABARAPL1.PE..GABARAPL1.(GABARAPL1).
type: Catalysis
controller: ATG4B
data source: Spike
control type: INHIBITION
controlled: Proteolytic.Processing.I.ATG4B.GABARAPL1.PE
xref: 20404487
xref: 14530254

BCL2L11
type: Protein
entity reference: BCL2L11

.ATG13.PROMOTES.ULK1.
type: Catalysis
controller: ATG13
data source: Spike
control type: ACTIVATION
controlled: Physical.Interaction.P.ATG13.ULK1
xref: 19225151
xref: 19258318
xref: 19211835

RPTOR
type: Protein
entity reference: RPTOR

21364619
type: PublicationXref
id: 21364619
db: PubMed
title: Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

GABARAP family.family
type: Protein
member physical entity: GABARAPL2
member physical entity: GABARAPL1
member physical entity: GABARAP
data source: Spike
xref: WSC:F.000022

.Family.RAG....PROMOTES.MTOR.
type: Catalysis
controller: RAG.family
data source: Spike
control type: ACTIVATION
controlled: Physical.Interaction.P.RAG.MTOR
xref: 18604198
xref: 18497260

http://www.ncbi.nlm.nih.gov/#983
type: UnificationXref
id: 983
db: Entrez Gene

ULK2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9706

DAP
type: Protein
entity reference: DAP

KIAA0226
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9711

8448036
type: PublicationXref
id: 8448036
db: PubMed
title: Cytoplasmic microtubule-based motor proteins

C12orf44
type: Protein
entity reference: C12orf44

MCL1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4170

.PINK1.PROMOTES.BECN1.
type: Catalysis
controller: PINK1
data source: Spike
control type: ACTIVATION
controlled: Physical.Interaction.P.PINK1.BECN1
xref: 20057503

21071439
type: PublicationXref
id: 21071439
db: PubMed
title: ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1)

http://www.ncbi.nlm.nih.gov/#472
type: UnificationXref
id: 472
db: Entrez Gene

PIK3C3
type: Protein
entity reference: PIK3C3

21062745
type: PublicationXref
id: 21062745
db: PubMed
title: The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression

GABARAP_inactive
type: Protein
entity reference: GABARAP

17517883
type: PublicationXref
id: 17517883
db: PubMed
title: The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1

.MTOR.INHIBITS.ULK2.
type: Catalysis
controller: MTOR
data source: Spike
control type: INHIBITION
controlled: Phosphorylation.I.MTOR.ULK2
xref: 19225151

MAP1LC3B
type: Protein
entity reference: MAP1LC3B

.FOXO1.PROMOTES.ATG7.
type: Catalysis
controller: FOXO1
data source: Spike
control type: ACTIVATION
controlled: Physical.Interaction.P.FOXO1.ATG7
xref: 20543840

AMPK.complex_inactive
type: Protein

AKT1
type: Protein
entity reference: AKT1

20505359
type: PublicationXref
id: 20505359
db: PubMed
title: Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation

UVRAG_inactive
type: Protein
entity reference: UVRAG

11265251
type: PublicationXref
id: 11265251
db: PubMed
title: Molecular dissection of autophagy: two ubiquitin-like systems

.DAPK1.INHIBITS.Family.ERK...(MAPK6).
type: Catalysis
controller: DAPK1
data source: Spike
control type: INHIBITION
controlled: Physical.Interaction.I.DAPK1.ERK
xref: 15616583

FKBP8
type: Protein
entity reference: FKBP8

DAPK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1612

http://www.ncbi.nlm.nih.gov/#81631
type: UnificationXref
id: 81631
db: Entrez Gene

PE
type: SmallMolecule
entity reference: PE

.UVRAG.PROMOTES.BECN1.
type: Catalysis
controller: UVRAG
data source: Spike
control type: ACTIVATION
controlled: Physical.Interaction.P.UVRAG.BECN1
xref: 16799551

GABARAPL2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#11345

9731710
type: PublicationXref
id: 9731710
db: PubMed
title: BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members

AMP
type: SmallMolecule
entity reference: AMP

.Family.RSK1/2....INHIBITS.TSC2.
type: Catalysis
controller: RSK1/2.family
data source: Spike
control type: INHIBITION
controlled: Phosphorylation.I.RSK1/2.TSC2
xref: 15342917

.Family.ERK....PROMOTES.Family.RSK1/2...(RPS6KA1).
type: Catalysis
controller: ERK.family
data source: Spike
control type: ACTIVATION
controlled: Phosphorylation.P.ERK.RSK1/2
xref: 9430688
xref: 8939914
xref: 9915826
xref: 7688567

ULK2
type: Protein
entity reference: ULK2

20057503
type: PublicationXref
id: 20057503
db: PubMed
title: The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy

.Complex.hVps34.Complex.II..BECN1,.PIK3C3,.UVRAG,.PIK3R4..PROMOTES.PI3P.
type: Catalysis
controller: Vps34 Class III PI3K complex with UVRAG
data source: Spike
control type: ACTIVATION
controlled: Phosphorylation.P.hVps34.Complex.II.PI3P
xref: 19223761
xref: 18843052

MTMR3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8897

17991864
type: PublicationXref
id: 17991864
db: PubMed
title: Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38

12234250
type: PublicationXref
id: 12234250
db: PubMed
title: Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366

TSC1
type: Protein
entity reference: TSC1

17053865
type: PublicationXref
id: 17053865
db: PubMed
title: A PI3K pathway mediates hair cell survival and opposes gentamicin toxicity in neonatal rat organ of Corti

http://www.ncbi.nlm.nih.gov/#55054
type: UnificationXref
id: 55054
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#64223
type: UnificationXref
id: 64223
db: Entrez Gene

RHEB
type: Protein
entity reference: RHEB

.Family.Calpains....INHIBITS.ATG5.
type: Catalysis
controller: Calpains.family
data source: Spike
control type: INHIBITION
controlled: Proteolytic.Processing.I.Calpains.ATG5
xref: 16998475

19549685
type: PublicationXref
id: 19549685
db: PubMed
title: Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis

.ATG4B.PROMOTES.MAP1LC3B.
type: Catalysis
controller: ATG4B
data source: Spike
control type: ACTIVATION
controlled: Proteolytic.Processing.P.ATG4B.MAP1LC3B
xref: 11038174

STK11
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6794

17337444
type: PublicationXref
id: 17337444
db: PubMed
title: Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein

10576742
type: PublicationXref
id: 10576742
db: PubMed
title: Phosphorylation and regulation of Raf by Akt (protein kinase B)

17244528
type: PublicationXref
id: 17244528
db: PubMed
title: Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2

Vps34 Class III PI3K complex with UVRAG
type: Complex
data source: Spike
component: PIK3R4
component: PIK3C3
component: BECN1
component: UVRAG
display name: hVps34 Complex II.complex

TNFAIP3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7128

18981720
type: PublicationXref
id: 18981720
db: PubMed
title: Role of ULK-FIP200 complex in mammalian autophagy: FIP200, a counterpart of yeast Atg17?

ULK2_inactive
type: Protein
entity reference: ULK2

PhysicalInteraction [KIAA0226 -- PIK3C3 ]
type: MolecularInteraction
xref: 21062745
participant: KIAA0226
participant: PIK3C3

http://www.ncbi.nlm.nih.gov/#55062
type: UnificationXref
id: 55062
db: Entrez Gene

12048182
type: PublicationXref
id: 12048182
db: PubMed
title: Regulation of Raf-Akt Cross-talk

FKBP8
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#23770

ATG4D_inactive
type: Protein
entity reference: ATG4D

.ULK2.PROMOTES.ATG13.
type: Catalysis
controller: ULK2
data source: Spike
control type: ACTIVATION
controlled: Phosphorylation.P.ULK2.ATG13
xref: 18936157

.MTMR14.INHIBITS.PI3P.
type: Catalysis
controller: MTMR14
data source: Spike
control type: INHIBITION
controlled: Dephosphorylation.I.MTMR14.PI3P
xref: 19590496

.Family.Calpains....PROMOTES.ATG5.
type: Catalysis
controller: Calpains.family
data source: Spike
control type: ACTIVATION
controlled: Proteolytic.Processing.P.Calpains.ATG5
xref: 16998475

.BCL2L11.INHIBITS.BCL2L1.
type: Catalysis
controller: BCL2L11
data source: Spike
control type: INHIBITION
controlled: Physical.Interaction.I.BCL2L11.BCL2L1
xref: 9731710
xref: 9430630

.Complex.AMPK....PROMOTES.TSC2.
type: Catalysis
controller: 5'-AMP-activated protein kinase
data source: Spike
control type: ACTIVATION
controlled: Phosphorylation.P.AMPK.TSC2
xref: 15231735

RSK1/2.family_inactive
type: Protein

GATE-16-PE.complex_inactive
type: Protein

WSC:F.000019
type: UnificationXref
id: WSC:F-000019
db: Spike DB

myosin II
type: Complex
data source: Spike
component: RLC (nonmuscle).family
display name: myosin II.complex

.Family.RSK1/2....INHIBITS.DAPK1.
type: Catalysis
controller: RSK1/2.family
data source: Spike
control type: INHIBITION
controlled: Phosphorylation.I.RSK1/2.DAPK1
xref: 16213824

16390869
type: PublicationXref
id: 16390869
db: PubMed
title: Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking

19225151
type: PublicationXref
id: 19225151
db: PubMed
title: ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

.ATG4B.INHIBITS.Complex.GATE.16.PE..PE,.GABARAPL2.(PE).
type: Catalysis
controller: ATG4B
data source: Spike
control type: INHIBITION
controlled: Proteolytic.Processing.I.ATG4B.GATE.16.PE
xref: 15187094
xref: 14530254

http://www.ncbi.nlm.nih.gov/#6009
type: UnificationXref
id: 6009
db: Entrez Gene

19050071
type: PublicationXref
id: 19050071
db: PubMed
title: Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase

KIAA0226
type: Protein
entity reference: KIAA0226

.Complex.hVPs34.Complex.III..BECN1,.PIK3C3,.UVRAG,.PIK3R4,.KIAA0226..PROMOTES.PI3P.
type: Catalysis
controller: vVps34 Class III PI3K complex with Rubicon
data source: Spike
control type: ACTIVATION
controlled: Phosphorylation.P.hVPs34.Complex.III.PI3P
xref: 19270693
xref: 19270696

WSC:F.000022
type: UnificationXref
id: WSC:F-000022
db: Spike DB

AMBRA1
type: Protein
entity reference: AMBRA1

TRAF6
type: Protein
entity reference: TRAF6

18497260
type: PublicationXref
id: 18497260
db: PubMed
title: The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

GABARAPL1 form II
type: Complex
data source: Spike
component: GABARAPL1
display name: GABARAPL1-PE.complex

21121091
type: PublicationXref
id: 21121091
db: PubMed
title: The in vitro cleavage of the hAtg proteins by cell death proteases

WIPI2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#26100

8621729
type: PublicationXref
id: 8621729
db: PubMed
title: Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells

9395281
type: PublicationXref
id: 9395281
db: PubMed
title: Ras-like GTPases

12150925
type: PublicationXref
id: 12150925
db: PubMed
title: mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

1849075
type: PublicationXref
id: 1849075
db: PubMed
title: Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase)

GABARAP-PE.complex_inactive
type: Protein

16244323
type: PublicationXref
id: 16244323
db: PubMed
title: Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways

CISD2
type: Protein
entity reference: CISD2

TSC1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7248

Atg5-Atg12 conjugation
type: Complex
data source: Spike
component: ATG5
component: ATG12
display name: Atg5/12.complex

9430688
type: PublicationXref
id: 9430688
db: PubMed
title: Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK

11100732
type: PublicationXref
id: 11100732
db: PubMed
title: A ubiquitin-like system mediates protein lipidation

11739631
type: PublicationXref
id: 11739631
db: PubMed
title: FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments

15661536
type: PublicationXref
id: 15661536
db: PubMed
title: TSC1-2 tumour suppressor and regulation of mTOR signalling: linking cell growth and proliferation?

14530254
type: PublicationXref
id: 14530254
db: PubMed
title: A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L

myosin II.complex_inactive
type: Protein

.Complex.Ca/CaM....PROMOTES.CAMKK2.
type: Catalysis
controller: Calcium-Calmodulin complex
data source: Spike
control type: ACTIVATION
controlled: Physical.Interaction.P.Ca/CaM.CAMKK2
xref: 11395482

http://www.ncbi.nlm.nih.gov/#8837
type: UnificationXref
id: 8837
db: Entrez Gene

ATG7
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#10533

http://www.ncbi.nlm.nih.gov/#2308
type: UnificationXref
id: 2308
db: Entrez Gene

DAPK1_inactive
type: Protein
entity reference: DAPK1

17604271
type: PublicationXref
id: 17604271
db: PubMed
title: PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex

18439900
type: PublicationXref
id: 18439900
db: PubMed
title: AMPK phosphorylation of raptor mediates a metabolic checkpoint

17386266
type: PublicationXref
id: 17386266
db: PubMed
title: PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

20022946
type: PublicationXref
id: 20022946
db: PubMed
title: mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action

.ULK1.PROMOTES.ATG13.
type: Catalysis
controller: ULK1
data source: Spike
control type: ACTIVATION
controlled: Phosphorylation.P.ULK1.ATG13
xref: 18936157

PI3P
type: SmallMolecule
entity reference: PI3P

mTOR complex1
type: Complex
data source: Spike
component: MLST8
display name: mTORC1.complex

WSC:F.000006
type: UnificationXref
id: WSC:F-000006
db: Spike DB

17595159
type: PublicationXref
id: 17595159
db: PubMed
title: siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy

WSC:F.000003
type: UnificationXref
id: WSC:F-000003
db: Spike DB

WSC:F.000004
type: UnificationXref
id: WSC:F-000004
db: Spike DB

http://www.ncbi.nlm.nih.gov/#5894
type: UnificationXref
id: 5894
db: Entrez Gene

AMBRA1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#55626

8939914
type: PublicationXref
id: 8939914
db: PubMed
title: Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases

PIK3C3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5289

15231735
type: PublicationXref
id: 15231735
db: PubMed
title: Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

.CFLAR.INHIBITS.ATG3.
type: Catalysis
controller: CFLAR
data source: Spike
control type: INHIBITION
controlled: Physical.Interaction.I.CFLAR.ATG3
xref: 19838173

ZFYVE1
type: Protein
entity reference: ZFYVE1

RB1CC1
type: Protein
entity reference: RB1CC1

DAPK3_inactive
type: Protein
entity reference: DAPK3

15616583
type: PublicationXref
id: 15616583
db: PubMed
title: Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK

DYNLL1
type: Protein
entity reference: DYNLL1

GABARAPL1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#23710

11038174
type: PublicationXref
id: 11038174
db: PubMed
title: The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway

.ULK1.UNKNOWN.ULK1.
type: Catalysis
controller: ULK1
data source: Spike
control type: ACTIVATION_UNKMECH
controlled: Phosphorylation.U.ULK1.ULK1
xref: 18936157

16288292
type: PublicationXref
id: 16288292
db: PubMed
title: Perturbations of the AKT signaling pathway in human cancer

18843052
type: PublicationXref
id: 18843052
db: PubMed
title: Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG

PhysicalInteraction [WIPI2 -- PI3P ]
type: MolecularInteraction
xref: 20505359
participant: WIPI2
participant: PI3P

20059746
type: PublicationXref
id: 20059746
db: PubMed
title: Modulation of local PtdIns3P levels by the PI phosphatase MTMR3 regulates constitutive autophagy

CAMKK2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#10645

CASP3
type: Protein
entity reference: CASP3

.MLST8.PROMOTES.MTOR.
type: Catalysis
controller: MLST8
data source: Spike
control type: ACTIVATION
controlled: Physical.Interaction.P.MLST8.MTOR
xref: 12718876

.BCL2L11.INHIBITS.BCL2.
type: Catalysis
controller: BCL2L11
data source: Spike
control type: INHIBITION
controlled: Physical.Interaction.I.BCL2L11.BCL2
xref: 9731710

GABARAPL2
type: Protein
entity reference: GABARAPL2

.MTMR3.INHIBITS.PI3P.
type: Catalysis
controller: MTMR3
data source: Spike
control type: INHIBITION
controlled: Dephosphorylation.I.MTMR3.PI3P
xref: 20059746

http://www.ncbi.nlm.nih.gov/#2475
type: UnificationXref
id: 2475
db: Entrez Gene

16098514
type: PublicationXref
id: 16098514
db: PubMed
title: Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1

21169990
type: PublicationXref
id: 21169990
db: PubMed
title: Atg1-mediated myosin II activation regulates autophagosome formation during starvation-induced autophagy

.CDK5.INHIBITS.PIK3C3.
type: Catalysis
controller: CDK5
data source: Spike
control type: INHIBITION
controlled: Phosphorylation.I.CDK5.PIK3C3
xref: 20513426

http://www.ncbi.nlm.nih.gov/#115201
type: UnificationXref
id: 115201
db: Entrez Gene

RSK1/2.family
type: Protein
data source: Spike
xref: WSC:F.000004

MKK1/2.family
type: Protein
data source: Spike
xref: TAU:F.000020

PMAIP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5366

BECN1
type: Protein
entity reference: BECN1

.PIK3R4.PROMOTES.PIK3C3.
type: Catalysis
controller: PIK3R4
data source: Spike
control type: ACTIVATION
controlled: Physical.Interaction.P.PIK3R4.PIK3C3
xref: 8999962

AMP
type: SmallMoleculeReference
xref: http://www.ebi.ac.uk/chebi/#16027

.PMAIP1.INHIBITS.MCL1.
type: Catalysis
controller: PMAIP1
data source: Spike
control type: INHIBITION
controlled: Physical.Interaction.I.PMAIP1.MCL1
xref: 15694340

.ATG4A.INHIBITS.Complex.GATE.16.PE..PE,.GABARAPL2.(PE).
type: Catalysis
controller: ATG4A
data source: Spike
control type: INHIBITION
controlled: Proteolytic.Processing.I.ATG4A.GATE.16.PE
xref: 12473658

http://www.ncbi.nlm.nih.gov/#7128
type: UnificationXref
id: 7128
db: Entrez Gene

.ATG14.PROMOTES.BECN1.
type: Catalysis
controller: ATG14
data source: Spike
control type: ACTIVATION
controlled: Physical.Interaction.P.ATG14.BECN1
xref: 19270693
xref: 19270696
xref: 19050071
xref: 19223761
xref: 18843052

21353614
type: PublicationXref
id: 21353614
db: PubMed
title: Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival

FKBP8_inactive
type: Protein
entity reference: FKBP8

8394352
type: PublicationXref
id: 8394352
db: PubMed
title: Activation of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase by G protein and tyrosine kinase oncoproteins

ATG4B
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#23192

.DYNLL1.INHIBITS.AMBRA1.
type: Catalysis
controller: DYNLL1
data source: Spike
control type: INHIBITION
controlled: Physical.Interaction.I.DYNLL1.AMBRA1
xref: 20921139

TRAF6
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7189

http://www.ncbi.nlm.nih.gov/#493856
type: UnificationXref
id: 493856
db: Entrez Gene

.ATG4A.PROMOTES.GABARAPL2.
type: Catalysis
controller: ATG4A
data source: Spike
control type: ACTIVATION
controlled: Proteolytic.Processing.P.ATG4A.GABARAPL2
xref: 12473658

.ATG4B.INHIBITS.Complex.LC3.PE..PE,.MAP1LC3B.(MAP1LC3B).
type: Catalysis
controller: ATG4B
data source: Spike
control type: INHIBITION
controlled: Proteolytic.Processing.I.ATG4B.LC3.PE
xref: 11038174
xref: 15187094

ATG4D
type: Protein
entity reference: ATG4D

9852036
type: PublicationXref
id: 9852036
db: PubMed
title: A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy

9606
type: UnificationXref
id: 9606
db: taxonomy

DYNLL1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8655

GABARAPL1-PE.complex_inactive
type: Protein

RHEB_inactive
type: Protein
entity reference: RHEB

ATG4A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#115201

ULK1_inactive
type: Protein
entity reference: ULK1

DAP_inactive
type: Protein
entity reference: DAP

.RHEB.PROMOTES.MTOR.
type: Catalysis
controller: RHEB
data source: Spike
control type: ACTIVATION
controlled: Physical.Interaction.P.RHEB.MTOR
xref: 18075516

HMGB1
type: Protein
entity reference: HMGB1

.AKT1S1.INHIBITS.MTOR.
type: Catalysis
controller: AKT1S1
data source: Spike
control type: INHIBITION
controlled: Indirect.I.AKT1S1.MTOR
xref: 17517883
xref: 18030348
xref: 17510057
xref: 17386266

http://www.ncbi.nlm.nih.gov/#1020
type: UnificationXref
id: 1020
db: Entrez Gene

RPTOR_inactive
type: Protein
entity reference: RPTOR

ATG13
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9776

.Family.RLC.(nonmuscle)....PROMOTES.Complex.myosin.II..Family.RLC.(nonmuscle)....(MYL6).
type: Catalysis
controller: RLC (nonmuscle).family
data source: Spike
control type: ACTIVATION
controlled: Other.P.RLC.(nonmuscle).myosin.II
xref: 10047526

MTOR
type: Protein
entity reference: MTOR

http://www.ncbi.nlm.nih.gov/#9474
type: UnificationXref
id: 9474
db: Entrez Gene

CDK5
type: Protein
entity reference: CDK5

.CASP3.PROMOTES.ATG4D.
type: Catalysis
controller: CASP3
data source: Spike
control type: ACTIVATION
controlled: Proteolytic.Processing.P.CASP3.ATG4D
xref: 19549685

CAMKK2
type: Protein
entity reference: CAMKK2

18722121
type: PublicationXref
id: 18722121
db: PubMed
title: Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation

RAF1_inactive
type: Protein
entity reference: RAF1

http://www.ncbi.nlm.nih.gov/#55626
type: UnificationXref
id: 55626
db: Entrez Gene

CDK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#983

http://www.ncbi.nlm.nih.gov/#51100
type: UnificationXref
id: 51100
db: Entrez Gene

GABARAP
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#11337

UVRAG
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7405

WIPI2
type: Protein
entity reference: WIPI2

BECN1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8678

.DAPK3.PROMOTES.DAPK3.
type: Catalysis
controller: DAPK3
data source: Spike
control type: ACTIVATION
controlled: Phosphorylation.P.DAPK3.DAPK3
xref: 15611134

10047526
type: PublicationXref
id: 10047526
db: PubMed
title: Molecular mechanisms of nonmuscle myosin-II regulation

ATG4D
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#84971

microtubules
type: Complex
data source: Spike
display name: MT.complex

10356987
type: PublicationXref
id: 10356987
db: PubMed
title: ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells

.Family.MKK1/2....PROMOTES.Family.ERK....
type: Catalysis
controller: MKK1/2.family
data source: Spike
control type: ACTIVATION
controlled: Phosphorylation.P.MKK1/2.ERK
xref: 17053865
xref: 1381507
xref: 1849075

PIK3R4
type: Protein
entity reference: PIK3R4

.Complex.AMPK....INHIBITS.RPTOR.
type: Catalysis
controller: 5'-AMP-activated protein kinase
data source: Spike
control type: INHIBITION
controlled: Phosphorylation.I.AMPK.RPTOR
xref: 18439900

RAF1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5894

MAP1LC3B
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#81631

8999962
type: PublicationXref
id: 8999962
db: PubMed
title: Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex

MTMR14
type: Protein
entity reference: MTMR14

.PE.PROMOTES.MAP1LC3B.
type: Catalysis
controller: PE
data source: Spike
control type: ACTIVATION
controlled: Physical.Interaction.P.PE.MAP1LC3B
xref: 11100732

CEN:F.329890
type: UnificationXref
id: CEN:F-329890
db: Spike DB

http://www.ncbi.nlm.nih.gov/#30849
type: UnificationXref
id: 30849
db: Entrez Gene

17618624
type: PublicationXref
id: 17618624
db: PubMed
title: Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy

.CISD2.PROMOTES.BCL2.
type: Catalysis
controller: CISD2
data source: Spike
control type: ACTIVATION
controlled: Physical.Interaction.P.CISD2.BCL2
xref: 20010695

15851026
type: PublicationXref
id: 15851026
db: PubMed
title: Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

16213824
type: PublicationXref
id: 16213824
db: PubMed
title: The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling

LC3-PE.complex_inactive
type: Protein

CDK5
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1020

CFLAR
type: Protein
entity reference: CFLAR

RB1CC1_inactive
type: Protein
entity reference: RB1CC1

12867426
type: PublicationXref
id: 12867426
db: PubMed
title: Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin

9765397
type: PublicationXref
id: 9765397
db: PubMed
title: Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein

AKT1S1
type: Protein
entity reference: AKT1S1

http://www.ncbi.nlm.nih.gov/#84971
type: UnificationXref
id: 84971
db: Entrez Gene

.C12orf44.PROMOTES.ATG13.
type: Catalysis
controller: C12orf44
data source: Spike
control type: ACTIVATION
controlled: Physical.Interaction.P.C12orf44.ATG13
xref: 19287211

.DAPK3.PROMOTES.Family.RLC.(nonmuscle)...(MYL12A).
type: Catalysis
controller: DAPK3
data source: Spike
control type: ACTIVATION
controlled: Phosphorylation.P.DAPK3.RLC.(nonmuscle)
xref: 15096528
xref: 10356987
xref: 11781833

BCL2
type: Protein
entity reference: BCL2

PIK3C3_inactive
type: Protein
entity reference: PIK3C3

http://www.ncbi.nlm.nih.gov/#10018
type: UnificationXref
id: 10018
db: Entrez Gene

RLC (nonmuscle).family
type: Protein
data source: Spike
xref: WSC:F.000019

19223761
type: PublicationXref
id: 19223761
db: PubMed
title: Atg14 and UVRAG: mutually exclusive subunits of mammalian Beclin 1-PI3K complexes

.TNFAIP3.INHIBITS.BECN1.
type: Catalysis
controller: TNFAIP3
data source: Spike
control type: INHIBITION
controlled: Deubiqitination.I.TNFAIP3.BECN1
xref: 20501938

.AMBRA1.PROMOTES.BECN1.
type: Catalysis
controller: AMBRA1
data source: Spike
control type: ACTIVATION
controlled: Physical.Interaction.P.AMBRA1.BECN1
xref: 17589504

ATG3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#64422

12718876
type: PublicationXref
id: 12718876
db: PubMed
title: GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

TSC2
type: Protein
entity reference: TSC2

dynein
type: Complex
data source: Spike
component: DYNLL1
display name: dynein.complex

.SH3GLB1.PROMOTES.PIK3C3.
type: Catalysis
controller: SH3GLB1
data source: Spike
control type: ACTIVATION
controlled: Indirect.P.SH3GLB1.PIK3C3
xref: 17891140

18443221
type: PublicationXref
id: 18443221
db: PubMed
title: FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

20921139
type: PublicationXref
id: 20921139
db: PubMed
title: The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

.RB1CC1.PROMOTES.ULK2.
type: Catalysis
controller: RB1CC1
data source: Spike
control type: ACTIVATION
controlled: Physical.Interaction.P.RB1CC1.ULK2
xref: 18936157

.Family.ERK....PROMOTES.RPTOR.
type: Catalysis
controller: ERK.family
data source: Spike
control type: ACTIVATION
controlled: Phosphorylation.P.ERK.RPTOR
xref: 21071439

9759731
type: PublicationXref
id: 9759731
db: PubMed
title: A protein conjugation system essential for autophagy

MLST8
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#64223

.TSC1.PROMOTES.TSC2.
type: Catalysis
controller: TSC1
data source: Spike
control type: ACTIVATION
controlled: Physical.Interaction.P.TSC1.TSC2
xref: 9580671

ERK.family_inactive
type: Protein

MTOR_inactive
type: Protein
entity reference: MTOR

.BCL2.INHIBITS.BECN1.
type: Catalysis
controller: BCL2
data source: Spike
control type: INHIBITION
controlled: Physical.Interaction.I.BCL2.BECN1
xref: 16179260
xref: 9765397

.TRAF6.PROMOTES.BECN1.
type: Catalysis
controller: TRAF6
data source: Spike
control type: ACTIVATION
controlled: Polyubiquitination.P.TRAF6.BECN1
xref: 20501938

PhysicalInteraction [ZFYVE1 -- PI3P ]
type: MolecularInteraction
xref: 11739631
xref: 11256955
xref: 18725538
participant: ZFYVE1
participant: PI3P

http://www.ncbi.nlm.nih.gov/#7248
type: UnificationXref
id: 7248
db: Entrez Gene

.RHEB.INHIBITS.FKBP8.
type: Catalysis
controller: RHEB
data source: Spike
control type: INHIBITION
controlled: Physical.Interaction.I.RHEB.FKBP8
xref: 17991864

BCL2L1_inactive
type: Protein
entity reference: BCL2L1

http://www.ncbi.nlm.nih.gov/#7249
type: UnificationXref
id: 7249
db: Entrez Gene

20501938
type: PublicationXref
id: 20501938
db: PubMed
title: TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy

11395482
type: PublicationXref
id: 11395482
db: PubMed
title: Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity

.FAM48A.PROMOTES.ATG9A.
type: Catalysis
controller: FAM48A
data source: Spike
control type: ACTIVATION
controlled: Physical.Interaction.P.FAM48A.ATG9A
xref: 19893488

9915826
type: PublicationXref
id: 9915826
db: PubMed
title: Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo

TNFAIP3
type: Protein
entity reference: TNFAIP3

.RB1CC1.PROMOTES.ULK1.
type: Catalysis
controller: RB1CC1
data source: Spike
control type: ACTIVATION
controlled: Indirect.P.RB1CC1.ULK1
xref: 19258318
xref: 18443221
xref: 18981720

ATG7_inactive
type: Protein
entity reference: ATG7

ATG14
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#22863

http://www.ncbi.nlm.nih.gov/#3146
type: UnificationXref
id: 3146
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#55578
type: UnificationXref
id: 55578
db: Entrez Gene

PINK1
type: Protein
entity reference: PINK1

CASP3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#836

Calcium-Calmodulin complex
type: Complex
data source: Spike
display name: Ca/CaM.complex

http://www.ncbi.nlm.nih.gov/#8897
type: UnificationXref
id: 8897
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#22863
type: UnificationXref
id: 22863
db: Entrez Gene

ULK1
type: Protein
entity reference: ULK1