Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation
Negative regulation of Vps34 by Cdk mediated phosphorylation
Identification of a C-terminal region that regulates mitogen-activated protein kinase kinase-1 cytoplasmic localization and ERK activation
The molecular motor toolbox for intracellular transport
Control of autophagy initiation by phosphoinositide 3-phosphatase Jumpy
Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product
The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A
Rheb binds and regulates the mTOR kinase
PhysicalInteraction [Complex MT {} -- Complex dynein {DYNLL1} ]
Mammalian Target of Rapamycin Complex 1 (mTORC1) Activity Is Associated with Phosphorylation of Raptor by mTOR
Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding
Caspase-mediated cleavage of ATG6/Beclin-1 links apoptosis to autophagy in HeLa cells
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis
Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis
ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products
Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1
Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages
Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate
GABARAPL1 (GEC1) associates with autophagic vesicles
Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi
BARgaining membranes for autophagosome formation: Regulation of autophagy and tumorigenesis by Bif-1/Endophilin B1
Regulation of an epitope-tagged recombinant Rsk-1 S6 kinase by phorbol ester and erk/MAP kinase
Regulation of TORC1 by Rag GTPases in nutrient response
B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222
FLIP-mediated autophagy regulation in cell death control
Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP
HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates
The paradox of autophagy and its implication in cancer etiology and therapy
Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL
Tor-mediated induction of autophagy via an Apg1 protein kinase complex
Apg16p is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway
A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy
Bcl-xL and UVRAG cause a monomer-dimer switch in Beclin1
Death-associated protein kinase phosphorylates ZIP kinase, forming a unique kinase hierarchy to activate its cell death functions
Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity
MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner
Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
DAP1, a novel substrate of mTOR, negatively regulates autophagy
BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites
Ambra1 regulates autophagy and development of the nervous system
Analysis of receptor signaling pathways by mass spectrometry: identification of vav-2 as a substrate of the epidermal and platelet-derived growth factor receptors
HeLa ZIP kinase induces diphosphorylation of myosin II regulatory light chain and reorganization of actin filaments in nonmuscle cells
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
vVps34 Class III PI3K complex with Rubicon
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells
PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding
Bim: a novel member of the Bcl-2 family that promotes apoptosis
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
ZIP kinase is responsible for the phosphorylation of myosin II and necessary for cell motility in mammalian fibroblasts
PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy
The AMP-activated protein kinase pathway--new players upstream and downstream
Regulation of zipper-interacting protein kinase activity in vitro and in vivo by multisite phosphorylation
Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria
Cytoplasmic microtubule-based motor proteins
ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1)
The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression
The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1
Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation
Molecular dissection of autophagy: two ubiquitin-like systems
BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members
The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy
Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38
Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366
A PI3K pathway mediates hair cell survival and opposes gentamicin toxicity in neonatal rat organ of Corti
Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis
Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein
Phosphorylation and regulation of Raf by Akt (protein kinase B)
Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2
Role of ULK-FIP200 complex in mammalian autophagy: FIP200, a counterpart of yeast Atg17?
PhysicalInteraction [KIAA0226 -- PIK3C3 ]
Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking
ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery
Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
The in vitro cleavage of the hAtg proteins by cell death proteases
Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase)
Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways
Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK
A ubiquitin-like system mediates protein lipidation
FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments
TSC1-2 tumour suppressor and regulation of mTOR signalling: linking cell growth and proliferation?
A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L
PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex
AMPK phosphorylation of raptor mediates a metabolic checkpoint
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action
siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy
Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases
Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK
The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway
Perturbations of the AKT signaling pathway in human cancer
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG
Modulation of local PtdIns3P levels by the PI phosphatase MTMR3 regulates constitutive autophagy
Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1
Atg1-mediated myosin II activation regulates autophagosome formation during starvation-induced autophagy
Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival
Activation of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase by G protein and tyrosine kinase oncoproteins
A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy
Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation
Molecular mechanisms of nonmuscle myosin-II regulation
ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells
Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex
Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy
Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis
The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling
Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin
Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein
Atg14 and UVRAG: mutually exclusive subunits of mammalian Beclin 1-PI3K complexes
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells
The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy
A protein conjugation system essential for autophagy
TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy
Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity
Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo