.Family.Ras.GTPases....PROMOTES.RAF1.
type: Catalysis
xref: 9395281
controlled: Physical.Interaction.P.Ras.GTPases.RAF1
data source: Spike
control type: ACTIVATION
controller: Ras GTPases.family

http://www.ncbi.nlm.nih.gov/#8550
type: UnificationXref
db: Entrez Gene
id: 8550

12242151
type: PublicationXref
db: PubMed
title: Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
id: 12242151

HTRA2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#27429
organism: Homo sapiens

TNFRSF10A_inactive
type: Protein
entity reference: TNFRSF10A

BIRC5_RNA
type: RnaRegion
entity reference: BIRC5

.CASP8.PROMOTES.BID.
type: Catalysis
xref: 9727491
xref: 9727492
controlled: Proteolytic.Processing.P.CASP8.BID
data source: Spike
control type: ACTIVATION
controller: CASP8

21357539
type: PublicationXref
db: PubMed
title: The phosphatase SRC homology region 2 domain-containing phosphatase-1 is an intrinsic central regulator of dendritic cell function
id: 21357539

.PMAIP1.INHIBITS.BCL2L1.
type: Catalysis
xref: 15725726
xref: 10807576
controlled: Physical.Interaction.I.PMAIP1.BCL2L1
data source: Spike
control type: INHIBITION
controller: PMAIP1

TP63_DNA
type: DnaRegion
entity reference: TP63

.PMAIP1.INHIBITS.BCL2.
type: Catalysis
xref: 15725726
xref: 10807576
controlled: Physical.Interaction.I.PMAIP1.BCL2
data source: Spike
control type: INHIBITION
controller: PMAIP1

11994401
type: PublicationXref
db: PubMed
title: Stat proteins and oncogenesis
id: 11994401

BAG4
type: Protein
entity reference: BAG4

11909874
type: PublicationXref
db: PubMed
title: HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter
id: 11909874

10438924
type: PublicationXref
db: PubMed
title: The B cell antigen receptor activates the Akt (protein kinase B)/glycogen synthase kinase-3 signaling pathway via phosphatidylinositol 3-kinase
id: 10438924

8900201
type: PublicationXref
db: PubMed
title: The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32
id: 8900201

.RIPK1.PROMOTES.Complex.IKK....
type: Catalysis
xref: 12654725
controlled: Physical.Interaction.P.RIPK1.IKK
data source: Spike
control type: ACTIVATION
controller: RIPK1

SH3GLB1
type: Protein
entity reference: SH3GLB1

7536190
type: PublicationXref
db: PubMed
title: A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain
id: 7536190

.BIRC2.INHIBITS.CASP9.
type: Catalysis
xref: 9545235
xref: 9990849
controlled: Physical.Interaction.I.BIRC2.CASP9
data source: Spike
control type: INHIBITION
controller: BIRC2

AIFM1
type: Protein
entity reference: AIFM1

.BMF.INHIBITS.BCL2.
type: Catalysis
xref: 11546872
controlled: Physical.Interaction.I.BMF.BCL2
data source: Spike
control type: INHIBITION
controller: BMF

RIPK1
type: Protein
entity reference: RIPK1

APAF1_RNA
type: RnaRegion
entity reference: APAF1

.BAD.PROMOTES.CYCS.
type: Catalysis
xref: 15725726
controlled: Indirect.P.BAD.CYCS
data source: Spike
control type: ACTIVATION
controller: BAD

CASP8_inactive
type: Protein
entity reference: CASP8

.Family.ERK..MAPK1,.MAPK3..PROMOTES.STAT3.
type: Catalysis
xref: 17008315
controlled: Phosphorylation.P.ERK.STAT3
data source: Spike
control type: ACTIVATION
controller: ERK.family

http://www.ncbi.nlm.nih.gov/#9131
type: UnificationXref
db: Entrez Gene
id: 9131

CASP6
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#839
organism: Homo sapiens

TRAF2_inactive
type: Protein
entity reference: TRAF2

9381178
type: PublicationXref
db: PubMed
title: Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
id: 9381178

.TP53.INHIBITS.BIRC5.
type: TemplateReactionRegulation
control type: INHIBITION
xref: 11714700
controller: TP53
controlled: Transcription.Regulation.I.TP53.BIRC5
data source: Spike

MAP3K5
type: Protein
entity reference: MAP3K5

MCL1
type: Protein
entity reference: MCL1

10892748
type: PublicationXref
db: PubMed
title: A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction
id: 10892748

.ATM.PROMOTES.E2F1.
type: Catalysis
xref: 11459832
controlled: Phosphorylation.P.ATM.E2F1
data source: Spike
control type: ACTIVATION
controller: ATM

19442713
type: PublicationXref
db: PubMed
title: Dexamethasone protects auditory hair cells against TNFalpha-initiated apoptosis via activation of PI3K/Akt and NFkappaB signaling
id: 19442713

CASP6
type: Protein
entity reference: CASP6

.TP53.PROMOTES.PTEN.
type: TemplateReactionRegulation
control type: ACTIVATION
xref: 18431400
controller: TP53
controlled: Transcription.Regulation.P.TP53.PTEN
data source: Spike

.HTRA2.INHIBITS.Family.IAP.fam..BIRC2,.BIRC3,.XIAP,.BIRC5,.BIRC6..
type: Catalysis
xref: 12209154
controlled: Other.I.HTRA2.IAP.fam
data source: Spike
control type: INHIBITION
controller: HTRA2

.MAPK14.PROMOTES.MAPKAPK5.
type: Catalysis
xref: 9628874
controlled: Phosphorylation.P.MAPK14.MAPKAPK5
data source: Spike
control type: ACTIVATION
controller: MAPK14

15705586
type: PublicationXref
db: PubMed
title: Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection
id: 15705586

http://www.ncbi.nlm.nih.gov/#2935
type: UnificationXref
db: Entrez Gene
id: 2935

BIRC2_DNA
type: DnaRegion
entity reference: BIRC2

BCL2L1
type: Protein
entity reference: BCL2L1

EGFR
type: Protein
entity reference: EGFR

16540633
type: PublicationXref
db: PubMed
title: The phosphoinositide 3-kinase/Akt1/Par-4 axis: a cancer-selective therapeutic target
id: 16540633

17255949
type: PublicationXref
db: PubMed
title: Mxi2 promotes stimulus-independent ERK nuclear translocation
id: 17255949

8612133
type: PublicationXref
db: PubMed
title: TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex
id: 8612133

.CASP12.PROMOTES.CASP7.
type: Catalysis
xref: 12209154
controlled: Other.P.CASP12.CASP7
data source: Spike
control type: ACTIVATION
controller: CASP12

19408108
type: PublicationXref
db: PubMed
title: NF-kappaB Signaling in the Aging Process
id: 19408108

MCL1_inactive
type: Protein
entity reference: MCL1

.BBC3.INHIBITS.BCL2.
type: Catalysis
xref: 15694340
controlled: Physical.Interaction.I.BBC3.BCL2
data source: Spike
control type: INHIBITION
controller: BBC3

BCL2L1_RNA
type: RnaRegion
entity reference: BCL2L1

BMF
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#90427
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#664
type: UnificationXref
db: Entrez Gene
id: 664

Akt.family_inactive
type: Protein

18508759
type: PublicationXref
db: PubMed
title: MKP-1 represses JNK-mediated apoptosis via NF-kappa B regulation
id: 18508759

FAS_inactive
type: Protein
entity reference: FAS

Translation
type: MolecularInteraction
participant: TP53_inactive
participant: TP53_RNA

.MAPK1.PROMOTES.DAPK1.
type: Catalysis
xref: 15616583
controlled: Phosphorylation.P.MAPK1.DAPK1
data source: Spike
control type: ACTIVATION
controller: MAPK1

BID
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#637
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#1869
type: UnificationXref
db: Entrez Gene
id: 1869

http://www.ncbi.nlm.nih.gov/#2066
type: UnificationXref
db: Entrez Gene
id: 2066

.BMF.INHIBITS.MCL1.
type: Catalysis
xref: 11546872
controlled: Physical.Interaction.I.BMF.MCL1
data source: Spike
control type: INHIBITION
controller: BMF

.TP63.PROMOTES.FAS.
type: TemplateReactionRegulation
control type: ACTIVATION
xref: 15944736
controller: TP63
controlled: Transcription.Regulation.P.TP63.FAS
data source: Spike

.E2F1.PROMOTES.CDKN2A.
type: TemplateReactionRegulation
control type: ACTIVATION
xref: 11883935
xref: 18319725
controller: E2F1
controlled: Transcription.Regulation.P.E2F1.CDKN2A
data source: Spike

16251502
type: PublicationXref
db: PubMed
title: Exogenous nitric oxide stimulates cell proliferation via activation of a mitogen-activated protein kinase pathway in ovine fetoplacental artery endothelial cells
id: 16251502

10751398
type: PublicationXref
db: PubMed
title: Involvement of two NF-kappa B binding elements in tumor necrosis factor alpha -, CD40-, and epstein-barr virus latent membrane protein 1-mediated induction of the cIAP2
id: 10751398

http://www.ncbi.nlm.nih.gov/#83737
type: UnificationXref
db: Entrez Gene
id: 83737

.Family.IkB....INHIBITS.Complex.NFkB..RELA..
type: Catalysis
xref: 10644043
controlled: Physical.Interaction.I.IkB.NFkB
data source: Spike
control type: INHIBITION
controller: IkB.family

DUSP1
type: Protein
entity reference: DUSP1

9922454
type: PublicationXref
db: PubMed
title: Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner
id: 9922454

BAX
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#581
organism: Homo sapiens

.TRIM28.INHIBITS.BBC3.
type: TemplateReactionRegulation
control type: INHIBITION
xref: 17942393
controller: TRIM28
controlled: Transcription.Regulation.I.TRIM28.BBC3
data source: Spike

BIRC5_DNA
type: DnaRegion
entity reference: BIRC5

TNFRSF1B
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7133
organism: Homo sapiens

SH3GLB1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#51100
organism: Homo sapiens

.CASP12.PROMOTES.CASP9.
type: Catalysis
xref: 15725726
controlled: Other.P.CASP12.CASP9
data source: Spike
control type: ACTIVATION
controller: CASP12

http://www.ncbi.nlm.nih.gov/#5290
type: UnificationXref
db: Entrez Gene
id: 5290

http://www.ncbi.nlm.nih.gov/#2074
type: UnificationXref
db: Entrez Gene
id: 2074

CDKN2A
type: Protein
entity reference: CDKN2A

TNFSF10
type: Protein
entity reference: TNFSF10

.TP53.PROMOTES.BID.
type: TemplateReactionRegulation
control type: ACTIVATION
xref: 12402042
xref: 18431400
controller: TP53
controlled: Transcription.Regulation.P.TP53.BID
data source: Spike

.CDKN2A.INHIBITS.MYC.
type: Catalysis
xref: 16915296
controlled: Physical.Interaction.I.CDKN2A.MYC
data source: Spike
control type: INHIBITION
controller: CDKN2A

MAP2K1_inactive
type: Protein
entity reference: MAP2K1

18644865
type: PublicationXref
db: PubMed
title: The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression
id: 18644865

DISC.complex
type: Complex
name: DISC (Primary complex) FADD, CASP8, CASP10
data source: Spike
component: TNFRSF1A
component: RIPK1
component: TNFRSF10A
component: TRAF2
component: TRADD

.DAPK1.INHIBITS.DAPK1.
type: Catalysis
xref: 11579085
controlled: Phosphorylation.I.DAPK1.DAPK1
data source: Spike
control type: INHIBITION
controller: DAPK1

9252186
type: PublicationXref
db: PubMed
title: A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB
id: 9252186

RAF1
type: Protein
entity reference: RAF1

CASP12_RNA
type: RnaRegion
entity reference: CASP12

STAT3_inactive
type: Protein
entity reference: STAT3

11326099
type: PublicationXref
db: PubMed
title: Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death
id: 11326099

.BIRC2.INHIBITS.CASP3.
type: Catalysis
xref: 9384571
xref: 9990849
xref: 12042762
controlled: Physical.Interaction.I.BIRC2.CASP3
data source: Spike
control type: INHIBITION
controller: BIRC2

Translation
type: MolecularInteraction
participant: TNFR-Signalosome.complex_RNA
participant: TNFR-Signalosome.complex

17488475
type: PublicationXref
db: PubMed
title: E2F1 death pathways as targets for cancer therapy
id: 17488475

TP53_inactive
type: Protein
entity reference: TP53

22119715
type: PublicationXref
db: PubMed
title: TGF- Promotes Proliferation of Thyroid Epithelial Cells in IFN-(-/-) Mice by Down-Regulation of p21 and p27 via AKT Pathway
id: 22119715

PMAIP1_RNA
type: RnaRegion
entity reference: PMAIP1

TNFR-Signalosome.complex_DNA
type: DnaRegion

Translation
type: MolecularInteraction
participant: BID_RNA
participant: BID_inactive

.BCL2L2.INHIBITS.BAX.
type: Catalysis
xref: 18178565
controlled: Physical.Interaction.I.BCL2L2.BAX
data source: Spike
control type: INHIBITION
controller: BCL2L2

12654725
type: PublicationXref
db: PubMed
title: The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation
id: 12654725

8626767
type: PublicationXref
db: PubMed
title: Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2
id: 8626767

BMF_inactive
type: Protein
entity reference: BMF

9463381
type: PublicationXref
db: PubMed
title: The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4
id: 9463381

BIRC5
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#332
organism: Homo sapiens

10934467
type: PublicationXref
db: PubMed
title: Negative regulation of the Apaf-1 apoptosome by Hsp70
id: 10934467

15169778
type: PublicationXref
db: PubMed
title: Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation
id: 15169778

http://www.ncbi.nlm.nih.gov/#207
type: UnificationXref
db: Entrez Gene
id: 207

.Complex.NFkB..RELA..PROMOTES.DUSP1.
type: TemplateReactionRegulation
control type: ACTIVATION
xref: 18508759
controller: NFkB.complex
controlled: Transcription.Regulation.P.NFkB.DUSP1
data source: Spike

CYCS
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#54205
organism: Homo sapiens

.TRAF2.PROMOTES.MAP3K5.
type: Catalysis
xref: 17724081
xref: 10688666
xref: 10523862
controlled: Physical.Interaction.P.TRAF2.MAP3K5
data source: Spike
control type: ACTIVATION
controller: TRAF2

15725726
type: PublicationXref
db: PubMed
title: Overview of cell death signaling pathways
id: 15725726

.MAP2K1.PROMOTES.Family.ERK..MAPK1,.MAPK3.(MAPK6).
type: Catalysis
xref: 16251502
controlled: Phosphorylation.P.MAP2K1.ERK
data source: Spike
control type: ACTIVATION
controller: MAP2K1

http://www.ncbi.nlm.nih.gov/#1432
type: UnificationXref
db: Entrez Gene
id: 1432

PIK3CA_DNA
type: DnaRegion
entity reference: PIK3CA

ITCH
type: Protein
entity reference: ITCH

http://www.ncbi.nlm.nih.gov/#114614
type: UnificationXref
db: Entrez Gene
id: 114614

BAG4
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#9530
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#7405
type: UnificationXref
db: Entrez Gene
id: 7405

.MAPK8IP1.PROMOTES.MAPK8.
type: Catalysis
xref: 9933567
controlled: Physical.Interaction.P.MAPK8IP1.MAPK8
data source: Spike
control type: ACTIVATION
controller: MAPK8IP1

.SIRT1.INHIBITS.TP53.
type: Catalysis
xref: 17964266
controlled: Deacetylation.I.SIRT1.TP53
data source: Spike
control type: INHIBITION
controller: SIRT1

.Family.JNK..MAPK8..PROMOTES.TP53.
type: Catalysis
xref: 11283254
controlled: Phosphorylation.P.JNK.TP53
data source: Spike
control type: ACTIVATION
controller: JNK.family

FASLG
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#356
organism: Homo sapiens

BNIP3
type: Protein
entity reference: BNIP3

http://www.ncbi.nlm.nih.gov/#6774
type: UnificationXref
db: Entrez Gene
id: 6774

BAX_RNA
type: RnaRegion
entity reference: BAX

EGR1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1958
organism: Homo sapiens

XIAP
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#331
organism: Homo sapiens

ERBB4
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2066
organism: Homo sapiens

ATM
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#472
organism: Homo sapiens

14729949
type: PublicationXref
db: PubMed
title: Suppression of PTEN expression by NF-kappa B prevents apoptosis
id: 14729949

http://www.ncbi.nlm.nih.gov/#841
type: UnificationXref
db: Entrez Gene
id: 841

.TP53.PROMOTES.BAX.
type: TemplateReactionRegulation
control type: ACTIVATION
xref: 7834749
controller: TP53
controlled: Transcription.Regulation.P.TP53.BAX
data source: Spike

http://www.ncbi.nlm.nih.gov/#842
type: UnificationXref
db: Entrez Gene
id: 842

11029458
type: PublicationXref
db: PubMed
title: Apoptosis signal-regulating kinase 1 (ASK1) is an intracellular inducer of keratinocyte differentiation
id: 11029458

CYCS
type: Protein
entity reference: CYCS

http://www.ncbi.nlm.nih.gov/#843
type: UnificationXref
db: Entrez Gene
id: 843

http://www.ncbi.nlm.nih.gov/#637
type: UnificationXref
db: Entrez Gene
id: 637

TNFRSF10D_inactive
type: Protein
entity reference: TNFRSF10D

UVRAG
type: Protein
entity reference: UVRAG

PDPK1
type: Protein
entity reference: PDPK1

http://www.ncbi.nlm.nih.gov/#840
type: UnificationXref
db: Entrez Gene
id: 840

http://www.ncbi.nlm.nih.gov/#839
type: UnificationXref
db: Entrez Gene
id: 839

http://www.ncbi.nlm.nih.gov/#835
type: UnificationXref
db: Entrez Gene
id: 835

http://www.ncbi.nlm.nih.gov/#836
type: UnificationXref
db: Entrez Gene
id: 836

Translation
type: MolecularInteraction
participant: CDKN2A_RNA
participant: CDKN2A_inactive

18448488
type: PublicationXref
db: PubMed
title: Rapid activation of Stat3 and ERK1/2 by nicotine modulates cell proliferation in human bladder cancer cells
id: 18448488

11459832
type: PublicationXref
db: PubMed
title: Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation
id: 11459832

14993273
type: PublicationXref
db: PubMed
title: Inhibition of the Jun N-terminal protein kinase pathway by SHIP-1, a lipid phosphatase that interacts with the adaptor molecule Dok-3
id: 14993273

.AKT1.INHIBITS.BAD.
type: Catalysis
xref: 14737178
xref: 9346240
xref: 9381178
xref: 16341064
controlled: Phosphorylation.I.AKT1.BAD
data source: Spike
control type: INHIBITION
controller: AKT1

.CASP9.PROMOTES.CASP3.
type: Catalysis
xref: 9390557
controlled: Proteolytic.Processing.P.CASP9.CASP3
data source: Spike
control type: ACTIVATION
controller: CASP9

12456688
type: PublicationXref
db: PubMed
title: Ubiquitylation of MEKK1 inhibits its phosphorylation of MKK1 and MKK4 and activation of the ERK1/2 and JNK pathways
id: 12456688

BNIP3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#664
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#1612
type: UnificationXref
db: Entrez Gene
id: 1612

DUSP1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1843
organism: Homo sapiens

PRKCZ
type: Protein
entity reference: PRKCZ

TP73_inactive
type: Protein
entity reference: TP73

CDKN1B_inactive
type: Protein
entity reference: CDKN1B

HTRA2_inactive
type: Protein
entity reference: HTRA2

12244301
type: PublicationXref
db: PubMed
title: PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization
id: 12244301

10381646
type: PublicationXref
db: PubMed
title: Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members
id: 10381646

TP53
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7157
organism: Homo sapiens

16170375
type: PublicationXref
db: PubMed
title: Onzin, a c-Myc-repressed target, promotes survival and transformation by modulating the Akt-Mdm2-p53 pathway
id: 16170375

7722458
type: PublicationXref
db: PubMed
title: The intracellular signal transduction mechanism of interleukin 5 in eosinophils: the involvement of lyn tyrosine kinase and the Ras-Raf-1-MEK-microtubule-associated protein kinase pathway
id: 7722458

.TRADD.PROMOTES.TRAF2.
type: Catalysis
xref: 10892748
xref: 8702708
xref: 8565075
controlled: Physical.Interaction.P.TRADD.TRAF2
data source: Spike
control type: ACTIVATION
controller: TRADD

http://www.ncbi.nlm.nih.gov/#4170
type: UnificationXref
db: Entrez Gene
id: 4170

FADD_inactive
type: Protein
entity reference: FADD

CYCS_inactive
type: Protein
entity reference: CYCS

.TNFSF10.PROMOTES.TNFRSF10D.
type: Catalysis
xref: 9430226
controlled: Physical.Interaction.P.TNFSF10.TNFRSF10D
data source: Spike
control type: ACTIVATION
controller: TNFSF10

RB1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5925
organism: Homo sapiens

15546863
type: PublicationXref
db: PubMed
title: Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM
id: 15546863

11709054
type: PublicationXref
db: PubMed
title: Mechanisms of p53-dependent apoptosis
id: 11709054

12574499
type: PublicationXref
db: PubMed
title: PUMA mediates the apoptotic response to p53 in colorectal cancer cells
id: 12574499

AIFM1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#9131
organism: Homo sapiens

MAP2K3
type: Protein
entity reference: MAP2K3

.PTEN.INHIBITS.AKT1.
type: Catalysis
xref: 15184909
controlled: Indirect.I.PTEN.AKT1
data source: Spike
control type: INHIBITION
controller: PTEN

.TNFSF10.PROMOTES.TNFRSF10C.
type: Catalysis
xref: 9314565
controlled: Physical.Interaction.P.TNFSF10.TNFRSF10C
data source: Spike
control type: ACTIVATION
controller: TNFSF10

http://www.ncbi.nlm.nih.gov/#90427
type: UnificationXref
db: Entrez Gene
id: 90427

JUND
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3727
organism: Homo sapiens

.JUNB.INHIBITS.BCL2.
type: TemplateReactionRegulation
control type: INHIBITION
xref: 11163237
controller: JUNB
controlled: Transcription.Regulation.I.JUNB.BCL2
data source: Spike

.Family.ERK..MAPK1,.MAPK3..PROMOTES.DAPK1.
type: Catalysis
xref: 15616583
controlled: Phosphorylation.P.ERK.DAPK1
data source: Spike
control type: ACTIVATION
controller: ERK.family

BCL2L11
type: Protein
entity reference: BCL2L11

CASP10
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#843
organism: Homo sapiens

MAPK14_inactive
type: Protein
entity reference: MAPK14

PRKCA
type: Protein
entity reference: PRKCA

.TNFSF10.PROMOTES.TNFRSF10B.
type: Catalysis
xref: 15538968
controlled: Physical.Interaction.P.TNFSF10.TNFRSF10B
data source: Spike
control type: ACTIVATION
controller: TNFSF10

TNFRSF10A
type: Protein
entity reference: TNFRSF10A

MDM2
type: Protein
entity reference: MDM2

http://www.ncbi.nlm.nih.gov/#4193
type: UnificationXref
db: Entrez Gene
id: 4193

.DDIT3.PROMOTES.JUND.
type: Catalysis
xref: 11426938
controlled: Physical.Interaction.P.DDIT3.JUND
data source: Spike
control type: ACTIVATION
controller: DDIT3

secondary DISC.complex
type: Complex
name: RIP1, TRAF2, NEMO, FADD, TRADD, caspase-8 caspase-10
data source: Spike
component: CASP10
component: FADD
component: CASP8

19788416
type: PublicationXref
db: PubMed
title: Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling - roles of p53, p73 and HIPK2
id: 19788416

FAS_DNA
type: DnaRegion
entity reference: FAS

.ATM.PROMOTES.TP53.
type: Catalysis
xref: 9733515
xref: 9733514
xref: 9843217
controlled: Phosphorylation.P.ATM.TP53
data source: Spike
control type: ACTIVATION
controller: ATM

http://www.ncbi.nlm.nih.gov/#472
type: UnificationXref
db: Entrez Gene
id: 472

17942393
type: PublicationXref
db: PubMed
title: Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression
id: 17942393

SIRT1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#23411
organism: Homo sapiens

MAPKAPK5_inactive
type: Protein
entity reference: MAPKAPK5

http://www.ncbi.nlm.nih.gov/#1649
type: UnificationXref
db: Entrez Gene
id: 1649

.TNFSF10.PROMOTES.TNFRSF10A.
type: Catalysis
xref: 15538968
controlled: Physical.Interaction.P.TNFSF10.TNFRSF10A
data source: Spike
control type: ACTIVATION
controller: TNFSF10

.MAPK14.PROMOTES.DDIT3.
type: Catalysis
xref: 11163539
xref: 11426938
controlled: Phosphorylation.P.MAPK14.DDIT3
data source: Spike
control type: ACTIVATION
controller: MAPK14

JUNB
type: Protein
entity reference: JUNB

.BIRC3.INHIBITS.CASP3.
type: Catalysis
xref: 9384571
xref: 9990849
xref: 12042762
controlled: Physical.Interaction.I.BIRC3.CASP3
data source: Spike
control type: INHIBITION
controller: BIRC3

BH3 fam.family
type: Protein
xref: TAU:F.000016
data source: Spike
member physical entity: BNIP3
member physical entity: BAD
member physical entity: BBC3
member physical entity: BID
member physical entity: PMAIP1
member physical entity: BCL2L11
member physical entity: BMF

9628874
type: PublicationXref
db: PubMed
title: PRAK, a novel protein kinase regulated by the p38 MAP kinase
id: 9628874

.MIR155HG.INHIBITS.FADD.
type: Catalysis
xref: 17911593
controlled: N/A.I.MIR155HG.FADD
data source: Spike
control type: INHIBITION
controller: MIR155HG

9228058
type: PublicationXref
db: PubMed
title: Characterization of Fas (Apo-1, CD95)-Fas ligand interaction
id: 9228058

.MAP2K3.PROMOTES.MAPK14.
type: Catalysis
xref: 11426938
controlled: Phosphorylation.P.MAP2K3.MAPK14
data source: Spike
control type: ACTIVATION
controller: MAP2K3

ARN:F.000001
type: UnificationXref
db: Spike DB
id: ARN:F-000001

DAPK1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1612
organism: Homo sapiens

.BAX.PROMOTES.CYCS.
type: Catalysis
xref: 12232790
xref: 11326099
controlled: Indirect.P.BAX.CYCS
data source: Spike
control type: ACTIVATION
controller: BAX

.Complex.PI3K..PIK3CA..PROMOTES.PDPK1.
type: Catalysis
xref: 12947395
xref: 17053865
controlled: Phosphorylation.P.PI3K.PDPK1
data source: Spike
control type: ACTIVATION
controller: PI3K.complex

11739185
type: PublicationXref
db: PubMed
title: Role of protein kinase C zeta isoform in Fas resistance of immature myeloid KG1a leukemic cells
id: 11739185

.UVRAG.PROMOTES.BECN1.
type: Catalysis
xref: 16799551
controlled: Physical.Interaction.P.UVRAG.BECN1
data source: Spike
control type: ACTIVATION
controller: UVRAG

PMAIP1_DNA
type: DnaRegion
entity reference: PMAIP1

9230442
type: PublicationXref
db: PubMed
title: X-linked IAP is a direct inhibitor of cell-death proteases
id: 9230442

.PRKCZ.INHIBITS.FADD.
type: Catalysis
xref: 11739185
controlled: Phosphorylation.I.PRKCZ.FADD
data source: Spike
control type: INHIBITION
controller: PRKCZ

PTEN_inactive
type: Protein
entity reference: PTEN

.CYCS.PROMOTES.APAF1.
type: Catalysis
xref: 9267021
controlled: Physical.Interaction.P.CYCS.APAF1
data source: Spike
control type: ACTIVATION
controller: CYCS

.MAPK3.PROMOTES.STAT3.
type: Catalysis
xref: 12681450
xref: 18448488
controlled: Phosphorylation.P.MAPK3.STAT3
data source: Spike
control type: ACTIVATION
controller: MAPK3

FOXO3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2309
organism: Homo sapiens

Translation
type: MolecularInteraction
participant: DUSP1_RNA
participant: DUSP1

10755617
type: PublicationXref
db: PubMed
title: Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation
id: 10755617

http://www.ncbi.nlm.nih.gov/#5777
type: UnificationXref
db: Entrez Gene
id: 5777

miR-34.family_DNA
type: DnaRegion

.XAF1.INHIBITS.XIAP.
type: Catalysis
xref: 12766484
controlled: Physical.Interaction.I.XAF1.XIAP
data source: Spike
control type: INHIBITION
controller: XAF1

9990849
type: PublicationXref
db: PubMed
title: IAP family proteins--suppressors of apoptosis
id: 9990849

.ERCC6.INHIBITS.TP53.
type: Catalysis
xref: 19221478
xref: 18784753
controlled: Physical.Interaction.I.ERCC6.TP53
data source: Spike
control type: INHIBITION
controller: ERCC6

http://www.ncbi.nlm.nih.gov/#8737
type: UnificationXref
db: Entrez Gene
id: 8737

9153240
type: PublicationXref
db: PubMed
title: Nonionic detergents induce dimerization among members of the Bcl-2 family
id: 9153240

17053865
type: PublicationXref
db: PubMed
title: A PI3K pathway mediates hair cell survival and opposes gentamicin toxicity in neonatal rat organ of Corti
id: 17053865

CASP6_inactive
type: Protein
entity reference: CASP6

.TP53.PROMOTES.TP63.
type: TemplateReactionRegulation
control type: ACTIVATION
xref: 18431400
controller: TP53
controlled: Transcription.Regulation.P.TP53.TP63
data source: Spike

TNFAIP3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7128
organism: Homo sapiens

DUSP1_RNA
type: RnaRegion
entity reference: DUSP1

CDKN2A_inactive
type: Protein
entity reference: CDKN2A

http://www.ncbi.nlm.nih.gov/#8743
type: UnificationXref
db: Entrez Gene
id: 8743

.GSPT1.INHIBITS.Family.IAP.fam..BIRC2,.BIRC3,.XIAP,.BIRC5,.BIRC6..
type: Catalysis
xref: 15725726
controlled: Physical.Interaction.I.GSPT1.IAP.fam
data source: Spike
control type: INHIBITION
controller: GSPT1

.RELA.INHIBITS.PTEN.
type: Catalysis
xref: 14729949
controlled: Indirect.I.RELA.PTEN
data source: Spike
control type: INHIBITION
controller: RELA

BIRC.family
type: Protein
xref: ARN:F.000001
data source: Spike
member physical entity: BIRC5
member physical entity: BIRC3
member physical entity: BIRC6
member physical entity: BIRC2

BCL2L2
type: Protein
entity reference: BCL2L2

TNF_DNA
type: DnaRegion
entity reference: TNF

UVRAG-BECN1-PIK3C3.complex
type: Complex
name: UVRAG-BECN1-PIK3C3
data source: Spike
component: BECN1
component: UVRAG

8630736
type: PublicationXref
db: PubMed
title: Regulation of Btk function by a major autophosphorylation site within the SH3 domain
id: 8630736

Translation
type: MolecularInteraction
participant: BBC3
participant: BBC3_RNA

BIF-1 BECLIN 1.complex
type: Complex
name: SH3GLB1-BECN-UVRAG
data source: Spike
component: SH3GLB1
component: BECN1
component: UVRAG

http://www.ncbi.nlm.nih.gov/#27113
type: UnificationXref
db: Entrez Gene
id: 27113

12242663
type: PublicationXref
db: PubMed
title: MEKK1-induced apoptosis requires TRAIL death receptor activation and is inhibited by AKT/PKB through inhibition of MEKK1 cleavage
id: 12242663

CASP7
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#840
organism: Homo sapiens

.MYC.INHIBITS.PLAC8.
type: TemplateReactionRegulation
control type: INHIBITION
xref: 16170375
controller: MYC
controlled: Transcription.Regulation.I.MYC.PLAC8
data source: Spike

TNFRSF10B
type: Protein
entity reference: TNFRSF10B

http://www.ncbi.nlm.nih.gov/#100506742
type: UnificationXref
db: Entrez Gene
id: 100506742

15262985
type: PublicationXref
db: PubMed
title: Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein
id: 15262985

8621729
type: PublicationXref
db: PubMed
title: Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells
id: 8621729

.AKT1.INHIBITS.CASP9.
type: Catalysis
xref: 9812896
xref: 16341064
controlled: Phosphorylation.I.AKT1.CASP9
data source: Spike
control type: INHIBITION
controller: AKT1

miR-34.family_RNA
type: RnaRegion

10634209
type: PublicationXref
db: PubMed
title: TNF-induced signaling in apoptosis
id: 10634209

http://www.ncbi.nlm.nih.gov/#142
type: UnificationXref
db: Entrez Gene
id: 142

MDM2_inactive
type: Protein
entity reference: MDM2

http://www.ncbi.nlm.nih.gov/#54739
type: UnificationXref
db: Entrez Gene
id: 54739

TP63_inactive
type: Protein
entity reference: TP63

.Complex.DNA.PK....PROMOTES.Complex.NFkB..RELA..
type: Catalysis
xref: 21872579
controlled: Phosphorylation.P.DNA.PK.NFkB
data source: Spike
control type: ACTIVATION
controller: DNA-PK.complex

18471544
type: PublicationXref
db: PubMed
title: Cellular and molecular mechanisms of liver injury
id: 18471544

Translation
type: MolecularInteraction
participant: DAPK1_RNA
participant: DAPK1_inactive

http://www.ncbi.nlm.nih.gov/#2309
type: UnificationXref
db: Entrez Gene
id: 2309

TNF
type: Protein
entity reference: TNF

.XIAP.INHIBITS.CASP3.
type: Catalysis
xref: 9230442
xref: 9525868
xref: 11447297
xref: 11927604
controlled: Ubiquitination.I.XIAP.CASP3
data source: Spike
control type: INHIBITION
controller: XIAP

MAP3K11
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4296
organism: Homo sapiens

20639885
type: PublicationXref
db: PubMed
title: The C terminus of p53 binds the N-terminal domain of MDM2
id: 20639885

9812896
type: PublicationXref
db: PubMed
title: Regulation of cell death protease caspase-9 by phosphorylation
id: 9812896

19395874
type: PublicationXref
db: PubMed
title: Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-X(L)
id: 19395874

BAK1
type: Protein
entity reference: BAK1

http://www.ncbi.nlm.nih.gov/#51316
type: UnificationXref
db: Entrez Gene
id: 51316

.MAP3K1.PROMOTES.Family.MKK4/7..MAP2K7,.MAP2K4..
type: Catalysis
xref: 12947395
controlled: Phosphorylation.P.MAP3K1.MKK4/7
data source: Spike
control type: ACTIVATION
controller: MAP3K1

9384571
type: PublicationXref
db: PubMed
title: The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
id: 9384571

18337766
type: PublicationXref
db: PubMed
title: Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy
id: 18337766

Translation
type: MolecularInteraction
participant: APAF1_inactive
participant: APAF1_RNA

BID_inactive
type: Protein
entity reference: BID

15616583
type: PublicationXref
db: PubMed
title: Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK
id: 15616583

.TNFAIP3.INHIBITS.Complex.TNFR.Signalosome..RIPK1,.TNFAIP3,.TNFRSF10A,.TNFRSF1A.(IKBKG).
type: TemplateReactionRegulation
control type: INHIBITION
xref: 10755617
controller: TNFAIP3
controlled: Transcription.Regulation.I.TNFAIP3.TNFR.Signalosome
data source: Spike

TNFRSF1A_inactive
type: Protein
entity reference: TNFRSF1A

.XIAP.INHIBITS.CASP7.
type: Catalysis
xref: 9230442
xref: 9525868
xref: 11359776
controlled: Physical.Interaction.I.XIAP.CASP7
data source: Spike
control type: INHIBITION
controller: XIAP

MAP2K3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5606
organism: Homo sapiens

TNF
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7124
organism: Homo sapiens

11447297
type: PublicationXref
db: PubMed
title: Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death
id: 11447297

.CDKN2A.INHIBITS.MDM2.
type: Catalysis
xref: 12209154
xref: 16915296
controlled: Physical.Interaction.I.CDKN2A.MDM2
data source: Spike
control type: INHIBITION
controller: CDKN2A

11426938
type: PublicationXref
db: PubMed
title: Stress-inducible transcription factor CHOP/gadd153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanisms
id: 11426938

CASP3
type: Protein
entity reference: CASP3

CASP2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#835
organism: Homo sapiens

12792650
type: PublicationXref
db: PubMed
title: Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK
id: 12792650

12766484
type: PublicationXref
db: PubMed
title: Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis
id: 12766484

11042193
type: PublicationXref
db: PubMed
title: Phospholipase C-gamma 2 couples Bruton's tyrosine kinase to the NF-kappaB signaling pathway in B lymphocytes
id: 11042193

http://www.ncbi.nlm.nih.gov/#8717
type: UnificationXref
db: Entrez Gene
id: 8717

CASP12_DNA
type: DnaRegion
entity reference: CASP12

MAP3K11
type: Protein
entity reference: MAP3K11

11390657
type: PublicationXref
db: PubMed
title: Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family
id: 11390657

MAP2K7
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5609
organism: Homo sapiens

MAPK1_inactive
type: Protein
entity reference: MAPK1

MAPK3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5595
organism: Homo sapiens

IkB.family
type: Protein
xref: TAU:F.000012
data source: Spike

Translation
type: MolecularInteraction
participant: CASP12
participant: CASP12_RNA

Translation
type: MolecularInteraction
participant: TP73_RNA
participant: TP73_inactive

BECN1
type: Protein
entity reference: BECN1

EGR1_inactive
type: Protein
entity reference: EGR1

BCL2-fam.family
type: Protein
xref: TAU:F.000015
data source: Spike
member physical entity: MCL1
member physical entity: BCL2L2
member physical entity: BCL2A1
member physical entity: BCL2
member physical entity: BCL2L1

12209154
type: PublicationXref
db: PubMed
title: The Bcl2 family: regulators of the cellular life-or-death switch
id: 12209154

15608685
type: PublicationXref
db: PubMed
title: dapk1, encoding an activator of a p19ARF-p53-mediated apoptotic checkpoint, is a transcription target of p53
id: 15608685

.TRIM28.INHIBITS.BAX.
type: TemplateReactionRegulation
control type: INHIBITION
xref: 17942393
controller: TRIM28
controlled: Transcription.Regulation.I.TRIM28.BAX
data source: Spike

RIPK1_inactive
type: Protein
entity reference: RIPK1

.Family.Ras.GTPases....PROMOTES.CDKN2A.
type: TemplateReactionRegulation
control type: ACTIVATION
xref: 12209154
controller: Ras GTPases.family
controlled: Transcription.Regulation.P.Ras.GTPases.CDKN2A
data source: Spike

.XIAP.INHIBITS.CASP9.
type: Catalysis
xref: 11927604
xref: 12042762
xref: 11390657
controlled: Physical.Interaction.I.XIAP.CASP9
data source: Spike
control type: INHIBITION
controller: XIAP

.Complex.NFkB..RELA..PROMOTES.BIRC2.
type: TemplateReactionRegulation
control type: ACTIVATION
xref: 9733516
controller: NFkB.complex
controlled: Transcription.Regulation.P.NFkB.BIRC2
data source: Spike

STAT3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6774
organism: Homo sapiens

11883935
type: PublicationXref
db: PubMed
title: Transcriptional regulation of the human tumor suppressor p14(ARF) by E2F1, E2F2, E2F3, and Sp1-like factors
id: 11883935

PLAC8
type: Protein
entity reference: PLAC8

9606
type: UnificationXref
db: taxonomy
id: 9606

TRIM28
type: Protein
entity reference: TRIM28

12681450
type: PublicationXref
db: PubMed
title: IL-2 activation of a PI3K-dependent STAT3 serine phosphorylation pathway in primary human T cells
id: 12681450

http://www.ncbi.nlm.nih.gov/#1843
type: UnificationXref
db: Entrez Gene
id: 1843

RELA
type: Protein
entity reference: RELA

.CFLAR.INHIBITS.CASP8.
type: Catalysis
xref: 9880531
controlled: Physical.Interaction.I.CFLAR.CASP8
data source: Spike
control type: INHIBITION
controller: CFLAR

CASP12
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#100506742
organism: Homo sapiens

FOXO3
type: Protein
entity reference: FOXO3

.DAPK1.INHIBITS.Family.ERK..MAPK1,.MAPK3.(MAPK6).
type: Catalysis
xref: 15616583
controlled: Physical.Interaction.I.DAPK1.ERK
data source: Spike
control type: INHIBITION
controller: DAPK1

.MAP3K5.PROMOTES.MAP2K3.
type: Catalysis
xref: 11029458
controlled: Phosphorylation.P.MAP3K5.MAP2K3
data source: Spike
control type: ACTIVATION
controller: MAP3K5

9267021
type: PublicationXref
db: PubMed
title: Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
id: 9267021

19074803
type: PublicationXref
db: PubMed
title: Stimulatory role of PKCalpha in extracellular regulated kinase 1/2 pathway in conjunctival goblet cell proliferation
id: 19074803

.BCL2L11.PROMOTES.BAX.
type: Catalysis
xref: 12198137
xref: 15721256
xref: 12242151
controlled: Other.P.BCL2L11.BAX
data source: Spike
control type: ACTIVATION
controller: BCL2L11

11163539
type: PublicationXref
db: PubMed
title: Peroxynitrite induces GADD34, 45, and 153 VIA p38 MAPK in human neuroblastoma SH-SY5Y cells
id: 11163539

http://www.ncbi.nlm.nih.gov/#1027
type: UnificationXref
db: Entrez Gene
id: 1027

http://www.ncbi.nlm.nih.gov/#1029
type: UnificationXref
db: Entrez Gene
id: 1029

9843217
type: PublicationXref
db: PubMed
title: ATM associates with and phosphorylates p53: mapping the region of interaction
id: 9843217

http://www.ncbi.nlm.nih.gov/#9479
type: UnificationXref
db: Entrez Gene
id: 9479

TRADD
type: Protein
entity reference: TRADD

TRAF2
type: Protein
entity reference: TRAF2

Akt.family
type: Protein
xref: TAU:F.000023
data source: Spike
member physical entity: AKT1

MAP3K1_inactive
type: Protein
entity reference: MAP3K1

10807576
type: PublicationXref
db: PubMed
title: Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
id: 10807576

MAP2K4
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6416
organism: Homo sapiens

.BCL2L1.INHIBITS.BAX.
type: Catalysis
xref: 9742125
xref: 9153240
xref: 11283018
xref: 9111042
xref: 18178565
controlled: Physical.Interaction.I.BCL2L1.BAX
data source: Spike
control type: INHIBITION
controller: BCL2L1

TNFRSF10C
type: Protein
entity reference: TNFRSF10C

CASP3_inactive
type: Protein
entity reference: CASP3

JNK.family
type: Protein
xref: TAU:F.000008
data source: Spike
member physical entity: MAPK8

PTEN
type: Protein
entity reference: PTEN

MIR155HG
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#114614
organism: Homo sapiens

BCL2L1_DNA
type: DnaRegion
entity reference: BCL2L1

9742085
type: PublicationXref
db: PubMed
title: Tumor necrosis factor alpha transcription in macrophages is attenuated by an autocrine factor that preferentially induces NF-kappaB p50
id: 9742085

11579085
type: PublicationXref
db: PubMed
title: The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism
id: 11579085

http://www.ncbi.nlm.nih.gov/#51100
type: UnificationXref
db: Entrez Gene
id: 51100

UVRAG
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7405
organism: Homo sapiens

BECN1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8678
organism: Homo sapiens

MAPK14
type: Protein
entity reference: MAPK14

BCL2L11_inactive
type: Protein
entity reference: BCL2L11

16227588
type: PublicationXref
db: PubMed
title: Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis
id: 16227588

MIR504
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#574507
organism: Homo sapiens

NFkB.complex_inactive
type: Protein

15200957
type: PublicationXref
db: PubMed
title: Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase
id: 15200957

.BBC3.PROMOTES.BAX.
type: Catalysis
xref: 15574335
controlled: Physical.Interaction.P.BBC3.BAX
data source: Spike
control type: ACTIVATION
controller: BBC3

9642236
type: PublicationXref
db: PubMed
title: Involvement of Ras in Bruton's tyrosine kinase-mediated JNK activation
id: 9642236

.ERBB4.INHIBITS.MDM2.
type: Catalysis
xref: 15985438
controlled: Phosphorylation.I.ERBB4.MDM2
data source: Spike
control type: INHIBITION
controller: ERBB4

9850056
type: PublicationXref
db: PubMed
title: IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs
id: 9850056

Translation
type: MolecularInteraction
participant: PMAIP1_RNA
participant: PMAIP1

.Family.Akt..AKT1..INHIBITS.MAP3K11.
type: Catalysis
xref: 11707464
controlled: N/A.I.Akt.MAP3K11
data source: Spike
control type: INHIBITION
controller: Akt.family

.Complex.NFkB..RELA..PROMOTES.BIRC3.
type: TemplateReactionRegulation
control type: ACTIVATION
xref: 10751398
controller: NFkB.complex
controlled: Transcription.Regulation.P.NFkB.BIRC3
data source: Spike

15901672
type: PublicationXref
db: PubMed
title: Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
id: 15901672

BAD
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#572
organism: Homo sapiens

9727491
type: PublicationXref
db: PubMed
title: Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
id: 9727491

9727492
type: PublicationXref
db: PubMed
title: Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
id: 9727492

.BAX.PROMOTES.HTRA2.
type: Catalysis
xref: 12232790
controlled: Indirect.P.BAX.HTRA2
data source: Spike
control type: ACTIVATION
controller: BAX

16189514
type: PublicationXref
db: PubMed
title: Towards a proteome-scale map of the human protein-protein interaction network
id: 16189514

11707464
type: PublicationXref
db: PubMed
title: Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation
id: 11707464

10207050
type: PublicationXref
db: PubMed
title: Cumulative effect of phosphorylation of pRB on regulation of E2F activity
id: 10207050

BIRC2_RNA
type: RnaRegion
entity reference: BIRC2

E2F1
type: Protein
entity reference: E2F1

.CASP7.INHIBITS.PARP1.
type: Catalysis
xref: 16374543
controlled: Proteolytic.Processing.I.CASP7.PARP1
data source: Spike
control type: INHIBITION
controller: CASP7

PTEN
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5728
organism: Homo sapiens

BAX fam.family
type: Protein
xref: TAU:F.000017
data source: Spike
member physical entity: BAK1
member physical entity: BAX

MAPK8
type: Protein
entity reference: MAPK8

18319725
type: PublicationXref
db: PubMed
title: A comprehensive modular map of molecular interactions in RB/E2F pathway
id: 18319725

BBC3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#27113
organism: Homo sapiens

TNFR-Signalosome.complex
type: Complex
name: TNFR-Signalosome
data source: Spike
component: TNFRSF1A
component: RIPK1
component: TNFRSF10A
component: TNFAIP3

IAP-fam.family
type: Protein
xref: TAU:F.000018
data source: Spike
member physical entity: BIRC5
member physical entity: BIRC3
member physical entity: BIRC6
member physical entity: BIRC2
member physical entity: XIAP

.RAF1.PROMOTES.MAP2K1.
type: Catalysis
xref: 8621729
xref: 18337766
xref: 17053865
xref: 8394352
controlled: Phosphorylation.P.RAF1.MAP2K1
data source: Spike
control type: ACTIVATION
controller: RAF1

Translation
type: MolecularInteraction
participant: BCL2_inactive
participant: BCL2_RNA

.SIRT1.INHIBITS.Complex.NFkB..RELA.(RELB).
type: Catalysis
xref: 19408108
xref: 15152190
xref: 18193389
controlled: Deacetylation.I.SIRT1.NFkB
data source: Spike
control type: INHIBITION
controller: SIRT1

MAP3K1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4214
organism: Homo sapiens

9126929
type: PublicationXref
db: PubMed
title: Identification of amino acid residues important for ligand binding to Fas
id: 9126929

.FOXO3.PROMOTES.PIK3CA.
type: TemplateReactionRegulation
control type: ACTIVATION
xref: 18644865
controller: FOXO3
controlled: Transcription.Regulation.P.FOXO3.PIK3CA
data source: Spike

9765397
type: PublicationXref
db: PubMed
title: Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein
id: 9765397

15718470
type: PublicationXref
db: PubMed
title: Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
id: 15718470

RIPK1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8737
organism: Homo sapiens

TRADD
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8717
organism: Homo sapiens

15505410
type: PublicationXref
db: PubMed
title: PI3K-Akt pathway: its functions and alterations in human cancer
id: 15505410

HTRA2
type: Protein
entity reference: HTRA2

http://www.ncbi.nlm.nih.gov/#8772
type: UnificationXref
db: Entrez Gene
id: 8772

.APAF1.PROMOTES.CASP9.
type: Catalysis
xref: 9922454
xref: 9488720
controlled: Physical.Interaction.P.APAF1.CASP9
data source: Spike
control type: ACTIVATION
controller: APAF1

Translation
type: MolecularInteraction
participant: TNF
participant: TNF_RNA

TNF_RNA
type: RnaRegion
entity reference: TNF

BIRC2
type: Protein
entity reference: BIRC2

HSPA1A
type: Protein
entity reference: HSPA1A

FASLG_DNA
type: DnaRegion
entity reference: FASLG

18784753
type: PublicationXref
db: PubMed
title: CSB protein is (a direct target of HIF-1 and) a critical mediator of the hypoxic response
id: 18784753

CDKN2A_DNA
type: DnaRegion
entity reference: CDKN2A

http://www.ncbi.nlm.nih.gov/#574507
type: UnificationXref
db: Entrez Gene
id: 574507

http://www.ncbi.nlm.nih.gov/#23411
type: UnificationXref
db: Entrez Gene
id: 23411

16684768
type: PublicationXref
db: PubMed
title: ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB
id: 16684768

DAPK1_RNA
type: RnaRegion
entity reference: DAPK1

.BAX.PROMOTES.CASP12.
type: TemplateReactionRegulation
control type: ACTIVATION
xref: 12209154
controller: BAX
controlled: Transcription.Regulation.P.BAX.CASP12
data source: Spike

14737178
type: PublicationXref
db: PubMed
title: JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis
id: 14737178

.BCL2.INHIBITS.BECN1.
type: Catalysis
xref: 16179260
xref: 9765397
controlled: Physical.Interaction.I.BCL2.BECN1
data source: Spike
control type: INHIBITION
controller: BCL2

.BCL2.INHIBITS.Complex.UVRAG.BECN1.PIK3C3..BECN1,.UVRAG.(BECN1).
type: Catalysis
xref: 16799551
controlled: Physical.Interaction.I.BCL2.UVRAG.BECN1.PIK3C3
data source: Spike
control type: INHIBITION
controller: BCL2

BCL2L1_inactive
type: Protein
entity reference: BCL2L1

TP73
type: Protein
entity reference: TP73

PLAC8
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#51316
organism: Homo sapiens

9169478
type: PublicationXref
db: PubMed
title: T cell proliferation in response to interleukins 2 and 7 requires p38MAP kinase activation
id: 9169478

.MYC.PROMOTES.CDKN2A.
type: TemplateReactionRegulation
control type: ACTIVATION
xref: 12209154
controller: MYC
controlled: Transcription.Regulation.P.MYC.CDKN2A
data source: Spike

Translation
type: MolecularInteraction
participant: PLAC8
participant: PLAC8_RNA

.BAG4.INHIBITS.TNFRSF1A.
type: Catalysis
xref: 18161752
controlled: Physical.Interaction.I.BAG4.TNFRSF1A
data source: Spike
control type: INHIBITION
controller: BAG4

.MAPK14.INHIBITS.MAPK3.
type: Catalysis
xref: 11238443
controlled: Physical.Interaction.I.MAPK14.MAPK3
data source: Spike
control type: INHIBITION
controller: MAPK14

MAPK8IP1
type: Protein
entity reference: MAPK8IP1

HSPA1A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3303
organism: Homo sapiens

BIRC6
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#57448
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#8795
type: UnificationXref
db: Entrez Gene
id: 8795

BID_RNA
type: RnaRegion
entity reference: BID

http://www.ncbi.nlm.nih.gov/#8797
type: UnificationXref
db: Entrez Gene
id: 8797

TNFRSF1B_inactive
type: Protein
entity reference: TNFRSF1B

http://www.ncbi.nlm.nih.gov/#8794
type: UnificationXref
db: Entrez Gene
id: 8794

http://www.ncbi.nlm.nih.gov/#8793
type: UnificationXref
db: Entrez Gene
id: 8793

DDIT3
type: Protein
entity reference: DDIT3

9430226
type: PublicationXref
db: PubMed
title: The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain
id: 9430226

http://www.ncbi.nlm.nih.gov/#22861
type: UnificationXref
db: Entrez Gene
id: 22861

11927604
type: PublicationXref
db: PubMed
title: The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites
id: 11927604

17254968
type: PublicationXref
db: PubMed
title: PRAK is essential for ras-induced senescence and tumor suppression
id: 17254968

.BID.PROMOTES.BAX.
type: Catalysis
xref: 15574335
controlled: Physical.Interaction.P.BID.BAX
data source: Spike
control type: ACTIVATION
controller: BID

21872579
type: PublicationXref
db: PubMed
title: Importance of PIKKs in NF-B activation by genotoxic stress
id: 21872579

CASP3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#836
organism: Homo sapiens

MAP2K7
type: Protein
entity reference: MAP2K7

16374543
type: PublicationXref
db: PubMed
title: Nuclear caspase-3 and caspase-7 activation, and poly(ADP-ribose) polymerase cleavage are early events in camptothecin-induced apoptosis
id: 16374543

.STAT3.PROMOTES.BCL2L1.
type: TemplateReactionRegulation
control type: ACTIVATION
xref: 11994401
controller: STAT3
controlled: Transcription.Regulation.P.STAT3.BCL2L1
data source: Spike

APAF1
type: Protein
entity reference: APAF1

11283018
type: PublicationXref
db: PubMed
title: In vitro selection and characterization of Bcl-X(L)-binding proteins from a mix of tissue-specific mRNA display libraries
id: 11283018

.BAX.PROMOTES.DIABLO.
type: Catalysis
xref: 12232790
controlled: Indirect.P.BAX.DIABLO
data source: Spike
control type: ACTIVATION
controller: BAX

BAK1_inactive
type: Protein
entity reference: BAK1

TP53_DNA
type: DnaRegion
entity reference: TP53

.BIRC5.INHIBITS.CASP7.
type: Catalysis
xref: 11170436
controlled: Physical.Interaction.I.BIRC5.CASP7
data source: Spike
control type: INHIBITION
controller: BIRC5

http://www.ncbi.nlm.nih.gov/#51074
type: UnificationXref
db: Entrez Gene
id: 51074

.MAPKAPK5.PROMOTES.TP53.
type: Catalysis
xref: 17254968
xref: 18568040
controlled: Phosphorylation.P.MAPKAPK5.TP53
data source: Spike
control type: ACTIVATION
controller: MAPKAPK5

7538907
type: PublicationXref
db: PubMed
title: FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
id: 7538907

.BCL2.INHIBITS.BAX.
type: Catalysis
xref: 8358790
xref: 9463381
xref: 9111042
controlled: Other.I.BCL2.BAX
data source: Spike
control type: INHIBITION
controller: BCL2

FASLG_RNA
type: RnaRegion
entity reference: FASLG

8702708
type: PublicationXref
db: PubMed
title: Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins
id: 8702708

Translation
type: MolecularInteraction
participant: BCL2L1_inactive
participant: BCL2L1_RNA

BCL2L2_inactive
type: Protein
entity reference: BCL2L2

PARP1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#142
organism: Homo sapiens

MAPK3
type: Protein
entity reference: MAPK3

BCL2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#596
organism: Homo sapiens

TP73
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7161
organism: Homo sapiens

10748187
type: PublicationXref
db: PubMed
title: ERK1b, a 46-kDa ERK isoform that is differentially regulated by MEK
id: 10748187

20542001
type: PublicationXref
db: PubMed
id: 20542001

11259440
type: PublicationXref
db: PubMed
title: Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax
id: 11259440

DAPK1
type: Protein
entity reference: DAPK1

.HSPA1A.INHIBITS.Complex.apoptosome..NLRP1,.CYCS,.APAF1.(APAF1).
type: Catalysis
xref: 10934467
controlled: Physical.Interaction.I.HSPA1A.apoptosome
data source: Spike
control type: INHIBITION
controller: HSPA1A

http://www.ncbi.nlm.nih.gov/#3303
type: UnificationXref
db: Entrez Gene
id: 3303

CDKN1B
type: Protein
entity reference: CDKN1B

Translation
type: MolecularInteraction
participant: BIRC3
participant: BIRC3_RNA

http://www.ncbi.nlm.nih.gov/#6416
type: UnificationXref
db: Entrez Gene
id: 6416

.EGR1.PROMOTES.TP53.
type: TemplateReactionRegulation
control type: ACTIVATION
xref: 12384981
controller: EGR1
controlled: Transcription.Regulation.P.EGR1.TP53
data source: Spike

9346240
type: PublicationXref
db: PubMed
title: Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
id: 9346240

MYC
type: Protein
entity reference: MYC

PLAC8_RNA
type: RnaRegion
entity reference: PLAC8

.MAP2K1.PROMOTES.MAPK3.
type: Catalysis
xref: 8626767
xref: 8226933
xref: 10748187
controlled: Phosphorylation.P.MAP2K1.MAPK3
data source: Spike
control type: ACTIVATION
controller: MAP2K1

.TRIM28.INHIBITS.PMAIP1.
type: TemplateReactionRegulation
control type: INHIBITION
xref: 17942393
controller: TRIM28
controlled: Transcription.Regulation.I.TRIM28.PMAIP1
data source: Spike

GSPT1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2935
organism: Homo sapiens

19579266
type: PublicationXref
db: PubMed
title: Efficient activation of p53 pathway in A549 cells exposed to L2, a novel compound targeting p53-MDM2 interaction
id: 19579266

11423996
type: PublicationXref
db: PubMed
title: DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1
id: 11423996

AKT1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#207
organism: Homo sapiens

TP73_RNA
type: RnaRegion
entity reference: TP73

17964266
type: PublicationXref
db: PubMed
title: Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity
id: 17964266

E2F1_inactive
type: Protein
entity reference: E2F1

.EGR1.PROMOTES.PTEN.
type: TemplateReactionRegulation
control type: ACTIVATION
xref: 12384981
controller: EGR1
controlled: Transcription.Regulation.P.EGR1.PTEN
data source: Spike

15694340
type: PublicationXref
db: PubMed
title: Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
id: 15694340

.FADD.PROMOTES.CASP8.
type: Catalysis
xref: 8681376
controlled: Physical.Interaction.P.FADD.CASP8
data source: Spike
control type: ACTIVATION
controller: FADD

11598012
type: PublicationXref
db: PubMed
title: PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization
id: 11598012

http://www.ncbi.nlm.nih.gov/#8678
type: UnificationXref
db: Entrez Gene
id: 8678

.PMAIP1.PROMOTES.BAX.
type: Catalysis
xref: 15705586
controlled: Physical.Interaction.P.PMAIP1.BAX
data source: Spike
control type: ACTIVATION
controller: PMAIP1

DIABLO_inactive
type: Protein
entity reference: DIABLO

.Complex.SMAD3.FOXOs....PROMOTES.CDKN2A.
type: TemplateReactionRegulation
control type: ACTIVATION
xref: 18391971
controller: SMAD3-FOXOs.complex
controlled: Transcription.Regulation.P.SMAD3.FOXOs.CDKN2A
data source: Spike

16179260
type: PublicationXref
db: PubMed
title: Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
id: 16179260

CASP7
type: Protein
entity reference: CASP7

TNFSF10
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8743
organism: Homo sapiens

STAT3
type: Protein
entity reference: STAT3

.PDPK1.PROMOTES.AKT1.
type: Catalysis
xref: 10207050
xref: 9169478
xref: 10438924
xref: 14993273
xref: 11598012
xref: 9104825
xref: 7722458
xref: 9252186
xref: 11042193
xref: 8630736
xref: 9642236
xref: 15718470
controlled: Phosphorylation.P.PDPK1.AKT1
data source: Spike
control type: ACTIVATION
controller: PDPK1

.Complex.NFkB..RELA..INHIBITS.TNF.
type: TemplateReactionRegulation
control type: INHIBITION
xref: 9742085
controller: NFkB.complex
controlled: Transcription.Regulation.I.NFkB.TNF
data source: Spike

17652152
type: PublicationXref
db: PubMed
title: Selective progesterone receptor modulator asoprisnil induces endoplasmic reticulum stress in cultured human uterine leiomyoma cells
id: 17652152

CDKN2A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1029
organism: Homo sapiens

PMAIP1
type: Protein
entity reference: PMAIP1

MAP2K1
type: Protein
entity reference: MAP2K1

.MAPK8.PROMOTES.BMF.
type: Catalysis
xref: 18222916
controlled: Phosphorylation.P.MAPK8.BMF
data source: Spike
control type: ACTIVATION
controller: MAPK8

.Family.Akt..AKT1..INHIBITS.MAP3K1.
type: Catalysis
xref: 12242663
controlled: Phosphorylation.I.Akt.MAP3K1
data source: Spike
control type: INHIBITION
controller: Akt.family

TRIM28
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#10155
organism: Homo sapiens

CASP12
type: Protein
entity reference: CASP12

11163237
type: PublicationXref
db: PubMed
title: Chronic myeloid leukemia with increased granulocyte progenitors in mice lacking junB expression in the myeloid lineage
id: 11163237

TNFRSF10C_inactive
type: Protein
entity reference: TNFRSF10C

http://www.ncbi.nlm.nih.gov/#9530
type: UnificationXref
db: Entrez Gene
id: 9530

TNFRSF1B
type: Protein
entity reference: TNFRSF1B

18568040
type: PublicationXref
db: PubMed
title: Ras oncogenes: split personalities
id: 18568040

.BCL2L11.INHIBITS.BCL2A1.
type: Catalysis
xref: 15694340
controlled: Physical.Interaction.I.BCL2L11.BCL2A1
data source: Spike
control type: INHIBITION
controller: BCL2L11

11437602
type: PublicationXref
db: PubMed
title: [W206R]-procaspase 3: an inactivatable substrate for caspase 8
id: 11437602

.MAPK1.INHIBITS.CASP9.
type: Catalysis
xref: 12792650
controlled: Phosphorylation.I.MAPK1.CASP9
data source: Spike
control type: INHIBITION
controller: MAPK1

CASP9_inactive
type: Protein
entity reference: CASP9

MDM2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4193
organism: Homo sapiens

AIFM1_inactive
type: Protein
entity reference: AIFM1

BAD
type: Protein
entity reference: BAD

http://www.ncbi.nlm.nih.gov/#7157
type: UnificationXref
db: Entrez Gene
id: 7157

.MAPK8.PROMOTES.BID.
type: Catalysis
xref: 18594987
controlled: N/A.P.MAPK8.BID
data source: Spike
control type: ACTIVATION
controller: MAPK8

.CASP2.PROMOTES.DIABLO.
type: Catalysis
xref: 11832478
controlled: Other.P.CASP2.DIABLO
data source: Spike
control type: ACTIVATION
controller: CASP2

.BMF.INHIBITS.BCL2L2.
type: Catalysis
xref: 11546872
controlled: Physical.Interaction.I.BMF.BCL2L2
data source: Spike
control type: INHIBITION
controller: BMF

http://www.ncbi.nlm.nih.gov/#3726
type: UnificationXref
db: Entrez Gene
id: 3726

http://www.ncbi.nlm.nih.gov/#3727
type: UnificationXref
db: Entrez Gene
id: 3727

.SH3GLB1.PROMOTES.BAK1.
type: Catalysis
xref: 16227588
controlled: Physical.Interaction.P.SH3GLB1.BAK1
data source: Spike
control type: ACTIVATION
controller: SH3GLB1

.BIRC5.INHIBITS.CASP3.
type: Catalysis
xref: 9850056
controlled: Physical.Interaction.I.BIRC5.CASP3
data source: Spike
control type: INHIBITION
controller: BIRC5

18594987
type: PublicationXref
db: PubMed
title: Involvement of JNK regulation in oxidative stress-mediated murine liver injury by microcystin-LR
id: 18594987

EGFR
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1956
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#57448
type: UnificationXref
db: Entrez Gene
id: 57448

http://www.ncbi.nlm.nih.gov/#7161
type: UnificationXref
db: Entrez Gene
id: 7161

Translation
type: MolecularInteraction
participant: PIK3CA_RNA
participant: PIK3CA

.BMF.INHIBITS.BCL2L1.
type: Catalysis
xref: 11546872
controlled: Physical.Interaction.I.BMF.BCL2L1
data source: Spike
control type: INHIBITION
controller: BMF

8226933
type: PublicationXref
db: PubMed
title: Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases
id: 8226933

BAK1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#578
organism: Homo sapiens

CASP8
type: Protein
entity reference: CASP8

ERBB4
type: Protein
entity reference: ERBB4

Translation
type: MolecularInteraction
participant: TP63_RNA
participant: TP63_inactive

http://www.ncbi.nlm.nih.gov/#4217
type: UnificationXref
db: Entrez Gene
id: 4217

PLAC8_DNA
type: DnaRegion
entity reference: PLAC8

ERCC6
type: Protein
entity reference: ERCC6

http://www.ncbi.nlm.nih.gov/#10155
type: UnificationXref
db: Entrez Gene
id: 10155

ATM
type: Protein
entity reference: ATM

MAP3K5
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4217
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#4214
type: UnificationXref
db: Entrez Gene
id: 4214

11463392
type: PublicationXref
db: PubMed
title: PUMA, a novel proapoptotic gene, is induced by p53
id: 11463392

15152190
type: PublicationXref
db: PubMed
title: Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
id: 15152190

BECN1_inactive
type: Protein
entity reference: BECN1

15985438
type: PublicationXref
db: PubMed
title: Secretase-dependent tyrosine phosphorylation of Mdm2 by the ErbB-4 intracellular domain fragment
id: 15985438

BCL2_RNA
type: RnaRegion
entity reference: BCL2

BAD_inactive
type: Protein
entity reference: BAD

BCL2L1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#598
organism: Homo sapiens

18178565
type: PublicationXref
db: PubMed
title: Differential regulation of Bax and Bak by anti-apoptotic Bcl-2 family proteins Bcl-B and Mcl-1
id: 18178565

15856024
type: PublicationXref
db: PubMed
title: Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells. Microarray analysis reveals defective induction of p53 target genes and upregulation of chaperone genes
id: 15856024

PIK3CA_RNA
type: RnaRegion
entity reference: PIK3CA

MAPKAPK5
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8550
organism: Homo sapiens

18222916
type: PublicationXref
db: PubMed
title: Phosphorylation of mitogen-activated protein kinase 8 (MAPK8) is associated with germ cell apoptosis and redistribution of the Bcl2-modifying factor (BMF)
id: 18222916

10523862
type: PublicationXref
db: PubMed
title: Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)
id: 10523862

.EGR1.PROMOTES.FASLG.
type: TemplateReactionRegulation
control type: ACTIVATION
xref: 11909874
controller: EGR1
controlled: Transcription.Regulation.P.EGR1.FASLG
data source: Spike

http://www.ncbi.nlm.nih.gov/#7186
type: UnificationXref
db: Entrez Gene
id: 7186

.DDIT3.INHIBITS.BCL2.
type: TemplateReactionRegulation
control type: INHIBITION
xref: 17652152
controller: DDIT3
controlled: Transcription.Regulation.I.DDIT3.BCL2
data source: Spike

RB1
type: Protein
entity reference: RB1

Homo sapiens
type: BioSource
xref: 9606

.CASP3.INHIBITS.PARP1.
type: Catalysis
xref: 7774019
controlled: Proteolytic.Processing.I.CASP3.PARP1
data source: Spike
control type: INHIBITION
controller: CASP3

.TP53.PROMOTES.PMAIP1.
type: TemplateReactionRegulation
control type: ACTIVATION
xref: 10807576
controller: TP53
controlled: Transcription.Regulation.P.TP53.PMAIP1
data source: Spike

MAP2K1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5604
organism: Homo sapiens

.MAP3K1.PROMOTES.MAP2K4.
type: Catalysis
xref: 12456688
controlled: Phosphorylation.P.MAP3K1.MAP2K4
data source: Spike
control type: ACTIVATION
controller: MAP3K1

BCL2_inactive
type: Protein
entity reference: BCL2

BCL2L2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#599
organism: Homo sapiens

9525868
type: PublicationXref
db: PubMed
title: A single BIR domain of XIAP sufficient for inhibiting caspases
id: 9525868

MAP2K4_inactive
type: Protein
entity reference: MAP2K4

.CASP8.PROMOTES.TP63.
type: Catalysis
xref: 17581882
controlled: Proteolytic.Processing.P.CASP8.TP63
data source: Spike
control type: ACTIVATION
controller: CASP8

CASP7_inactive
type: Protein
entity reference: CASP7

http://www.ncbi.nlm.nih.gov/#355
type: UnificationXref
db: Entrez Gene
id: 355

http://www.ncbi.nlm.nih.gov/#356
type: UnificationXref
db: Entrez Gene
id: 356

TAU:F.000011
type: UnificationXref
db: Spike DB
id: TAU:F-000011

10950869
type: PublicationXref
db: PubMed
title: tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c
id: 10950869

TAU:F.000012
type: UnificationXref
db: Spike DB
id: TAU:F-000012

TAU:F.000015
type: UnificationXref
db: Spike DB
id: TAU:F-000015

.ATM.PROMOTES.AKT1.
type: Catalysis
xref: 15546863
controlled: Phosphorylation.P.ATM.AKT1
data source: Spike
control type: ACTIVATION
controller: ATM

TAU:F.000017
type: UnificationXref
db: Spike DB
id: TAU:F-000017

secondary DISC.complex_inactive
type: Protein

JNK.family_inactive
type: Protein

TAU:F.000016
type: UnificationXref
db: Spike DB
id: TAU:F-000016

TAU:F.000019
type: UnificationXref
db: Spike DB
id: TAU:F-000019

CASP8
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#841
organism: Homo sapiens

TAU:F.000018
type: UnificationXref
db: Spike DB
id: TAU:F-000018

.BID.PROMOTES.BAK1.
type: Catalysis
xref: 10950869
controlled: Physical.Interaction.P.BID.BAK1
data source: Spike
control type: ACTIVATION
controller: BID

http://www.ncbi.nlm.nih.gov/#5599
type: UnificationXref
db: Entrez Gene
id: 5599

CFLAR
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8837
organism: Homo sapiens

JUNB
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3726
organism: Homo sapiens

19221478
type: PublicationXref
db: PubMed
title: Cockayne syndrome B protein (CSB): linking p53, HIF-1 and p300 to robustness, lifespan, cancer and cell fate decisions
id: 19221478

http://www.ncbi.nlm.nih.gov/#5590
type: UnificationXref
db: Entrez Gene
id: 5590

http://www.ncbi.nlm.nih.gov/#5595
type: UnificationXref
db: Entrez Gene
id: 5595

http://www.ncbi.nlm.nih.gov/#5594
type: UnificationXref
db: Entrez Gene
id: 5594

TAU:F.000023
type: UnificationXref
db: Spike DB
id: TAU:F-000023

IKK.complex
type: Complex
name: IKK complex
data source: Spike

7758105
type: PublicationXref
db: PubMed
title: The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation
id: 7758105

MIR504
type: Protein
entity reference: MIR504

CASP2
type: Protein
entity reference: CASP2

FAS
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#355
organism: Homo sapiens

DAPK1_DNA
type: DnaRegion
entity reference: DAPK1

NLRP1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#22861
organism: Homo sapiens

9733515
type: PublicationXref
db: PubMed
title: Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
id: 9733515

9733516
type: PublicationXref
db: PubMed
title: NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
id: 9733516

http://www.ncbi.nlm.nih.gov/#5170
type: UnificationXref
db: Entrez Gene
id: 5170

9733514
type: PublicationXref
db: PubMed
title: Enhanced phosphorylation of p53 by ATM in response to DNA damage
id: 9733514

http://www.ncbi.nlm.nih.gov/#330
type: UnificationXref
db: Entrez Gene
id: 330

http://www.ncbi.nlm.nih.gov/#4609
type: UnificationXref
db: Entrez Gene
id: 4609

http://www.ncbi.nlm.nih.gov/#331
type: UnificationXref
db: Entrez Gene
id: 331

http://www.ncbi.nlm.nih.gov/#332
type: UnificationXref
db: Entrez Gene
id: 332

11146619
type: PublicationXref
db: PubMed
title: DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation
id: 11146619

10929712
type: PublicationXref
db: PubMed
title: Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
id: 10929712

http://www.ncbi.nlm.nih.gov/#329
type: UnificationXref
db: Entrez Gene
id: 329

TNFRSF10D
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8793
organism: Homo sapiens

Translation
type: MolecularInteraction
participant: BIRC2_RNA
participant: BIRC2

.ATM.PROMOTES.BID.
type: Catalysis
xref: 18662573
xref: 16122426
xref: 16122425
controlled: Phosphorylation.P.ATM.BID
data source: Spike
control type: ACTIVATION
controller: ATM

.MDM2.INHIBITS.TP53.
type: Catalysis
xref: 11331603
xref: 20639885
xref: 19579266
controlled: Physical.Interaction.I.MDM2.TP53
data source: Spike
control type: INHIBITION
controller: MDM2

.STAT3.PROMOTES.BCL2.
type: TemplateReactionRegulation
control type: ACTIVATION
xref: 11994401
controller: STAT3
controlled: Transcription.Regulation.P.STAT3.BCL2
data source: Spike

CASP9
type: Protein
entity reference: CASP9

.MAP3K1.PROMOTES.MAP2K7.
type: Catalysis
xref: 12947395
controlled: Phosphorylation.P.MAP3K1.MAP2K7
data source: Spike
control type: ACTIVATION
controller: MAP3K1

http://www.ncbi.nlm.nih.gov/#5578
type: UnificationXref
db: Entrez Gene
id: 5578

BCL2L11
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#10018
organism: Homo sapiens

18662573
type: PublicationXref
db: PubMed
title: Investigation of the proapoptotic BCL-2 family member bid on the crossroad of the DNA damage response and apoptosis
id: 18662573

Translation
type: MolecularInteraction
participant: miR-34.family_RNA
participant: miR-34.family

.AKT1.INHIBITS.CDKN1B.
type: Catalysis
xref: 22119715
xref: 19377290
xref: 12244301
controlled: Phosphorylation.I.AKT1.CDKN1B
data source: Spike
control type: INHIBITION
controller: AKT1

18431400
type: PublicationXref
db: PubMed
title: Transcriptional control of human p53-regulated genes
id: 18431400

BID_DNA
type: DnaRegion
entity reference: BID

PARP1_inactive
type: Protein
entity reference: PARP1

.SH3GLB1.PROMOTES.BAX.
type: Catalysis
xref: 11259440
xref: 16227588
controlled: Physical.Interaction.P.SH3GLB1.BAX
data source: Spike
control type: ACTIVATION
controller: SH3GLB1

.TP53.PROMOTES.BBC3.
type: TemplateReactionRegulation
control type: ACTIVATION
xref: 11463392
xref: 12574499
controller: TP53
controlled: Transcription.Regulation.P.TP53.BBC3
data source: Spike

ITCH
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#83737
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#5970
type: UnificationXref
db: Entrez Gene
id: 5970

Ras GTPases.family
type: Protein
xref: TAU:F.000019
data source: Spike

apoptosome.complex_inactive
type: Protein

11559530
type: PublicationXref
db: PubMed
title: APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis
id: 11559530

11832478
type: PublicationXref
db: PubMed
title: Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria
id: 11832478

17560374
type: PublicationXref
db: PubMed
title: XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization
id: 17560374

BCL2_DNA
type: DnaRegion
entity reference: BCL2

15721256
type: PublicationXref
db: PubMed
title: BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly
id: 15721256

16799551
type: PublicationXref
db: PubMed
title: Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
id: 16799551

11988839
type: PublicationXref
db: PubMed
title: The human p73 promoter: characterization and identification of functional E2F binding sites
id: 11988839

MAP3K1
type: Protein
entity reference: MAP3K1

ERK.family
type: Protein
xref: TAU:F.000011
data source: Spike
member physical entity: MAPK3
member physical entity: MAPK1

BIRC3
type: Protein
entity reference: BIRC3

TRADD_inactive
type: Protein
entity reference: TRADD

.DUSP1.INHIBITS.Family.JNK..MAPK8..
type: Catalysis
xref: 18508759
controlled: Dephosphorylation.I.DUSP1.JNK
data source: Spike
control type: INHIBITION
controller: DUSP1

http://www.ncbi.nlm.nih.gov/#599
type: UnificationXref
db: Entrez Gene
id: 599

.TNFRSF1A.PROMOTES.TRADD.
type: Catalysis
xref: 7758105
xref: 8565075
controlled: Physical.Interaction.P.TNFRSF1A.TRADD
data source: Spike
control type: ACTIVATION
controller: TNFRSF1A

Translation
type: MolecularInteraction
participant: FASLG
participant: FASLG_RNA

PIK3CA
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5290
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#596
type: UnificationXref
db: Entrez Gene
id: 596

http://www.ncbi.nlm.nih.gov/#5366
type: UnificationXref
db: Entrez Gene
id: 5366

http://www.ncbi.nlm.nih.gov/#597
type: UnificationXref
db: Entrez Gene
id: 597

http://www.ncbi.nlm.nih.gov/#598
type: UnificationXref
db: Entrez Gene
id: 598

Spike
type: Provenance

AKT1_inactive
type: Protein
entity reference: AKT1

.E2F1.PROMOTES.APAF1.
type: TemplateReactionRegulation
control type: ACTIVATION
xref: 18319725
xref: 11389439
controller: E2F1
controlled: Transcription.Regulation.P.E2F1.APAF1
data source: Spike

.TP73.PROMOTES.FAS.
type: TemplateReactionRegulation
control type: ACTIVATION
xref: 19788416
controller: TP73
controlled: Transcription.Regulation.P.TP73.FAS
data source: Spike

.BAX.PROMOTES.APAF1.
type: Catalysis
xref: 11709054
controlled: Other.P.BAX.APAF1
data source: Spike
control type: ACTIVATION
controller: BAX

SMAD3-FOXOs.complex
type: Complex
name: SMAD3-FOXOs
data source: Spike

Translation
type: MolecularInteraction
participant: FAS_RNA
participant: FAS_inactive

miR-34.family
type: Protein
xref: TAU:F.329942
data source: Spike

.TP53.PROMOTES.DAPK1.
type: TemplateReactionRegulation
control type: ACTIVATION
xref: 15608685
controller: TP53
controlled: Transcription.Regulation.P.TP53.DAPK1
data source: Spike

XAF1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#54739
organism: Homo sapiens

FADD
type: Protein
entity reference: FADD

.MAPK8.INHIBITS.BCL2.
type: Catalysis
xref: 18471544
controlled: Other.I.MAPK8.BCL2
data source: Spike
control type: INHIBITION
controller: MAPK8

19180116
type: PublicationXref
db: PubMed
title: DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy
id: 19180116

http://www.ncbi.nlm.nih.gov/#317
type: UnificationXref
db: Entrez Gene
id: 317

FADD
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8772
organism: Homo sapiens

Translation
type: MolecularInteraction
participant: BIRC5
participant: BIRC5_RNA

.Family.MKK4/7..MAP2K7,.MAP2K4..PROMOTES.Family.JNK..MAPK8..
type: Catalysis
xref: 9626657
controlled: Phosphorylation.P.MKK4/7.JNK
data source: Spike
control type: ACTIVATION
controller: MKK4/7.family

11170436
type: PublicationXref
db: PubMed
title: An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7
id: 11170436

MAPK8IP1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#9479
organism: Homo sapiens

TRAF2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7186
organism: Homo sapiens

.TP53.PROMOTES.Family.miR.34...(MIR34A).
type: TemplateReactionRegulation
control type: ACTIVATION
xref: 18451145
controller: TP53
controlled: Transcription.Regulation.P.TP53.miR.34
data source: Spike

10688666
type: PublicationXref
db: PubMed
title: Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin
id: 10688666

.ITCH.INHIBITS.TP73.
type: Catalysis
xref: 19788416
controlled: Ubiquitination.I.ITCH.TP73
data source: Spike
control type: INHIBITION
controller: ITCH

16915296
type: PublicationXref
db: PubMed
title: Divorcing ARF and p53: an unsettled case
id: 16915296

APIP
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#51074
organism: Homo sapiens

.PMAIP1.INHIBITS.BCL2A1.
type: Catalysis
xref: 15694340
controlled: Physical.Interaction.I.PMAIP1.BCL2A1
data source: Spike
control type: INHIBITION
controller: PMAIP1

11359776
type: PublicationXref
db: PubMed
title: X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes
id: 11359776

PDPK1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5170
organism: Homo sapiens

18451145
type: PublicationXref
db: PubMed
title: Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence
id: 18451145

17604722
type: PublicationXref
db: PubMed
title: ER stress triggers apoptosis by activating BH3-only protein Bim
id: 17604722

IKK.complex_inactive
type: Protein

MCL1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4170
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#572
type: UnificationXref
db: Entrez Gene
id: 572

.APIP.INHIBITS.APAF1.
type: Catalysis
xref: 15262985
controlled: Physical.Interaction.I.APIP.APAF1
data source: Spike
control type: INHIBITION
controller: APIP

http://www.ncbi.nlm.nih.gov/#4296
type: UnificationXref
db: Entrez Gene
id: 4296

.MAPK3.INHIBITS.BCL2L11.
type: Catalysis
xref: 17604722
controlled: Phosphorylation.I.MAPK3.BCL2L11
data source: Spike
control type: INHIBITION
controller: MAPK3

http://www.ncbi.nlm.nih.gov/#578
type: UnificationXref
db: Entrez Gene
id: 578

EGR1
type: Protein
entity reference: EGR1

http://www.ncbi.nlm.nih.gov/#5925
type: UnificationXref
db: Entrez Gene
id: 5925

8358790
type: PublicationXref
db: PubMed
title: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
id: 8358790

DNA-PK.complex
type: Complex
name: DNA-PK
data source: Spike

.MAPK8.INHIBITS.BCL2L1.
type: Catalysis
xref: 18471544
controlled: mRNA.stability.I.MAPK8.BCL2L1
data source: Spike
control type: INHIBITION
controller: MAPK8

TP63_RNA
type: RnaRegion
entity reference: TP63

AKT1
type: Protein
entity reference: AKT1

19377290
type: PublicationXref
db: PubMed
title: AKT1 mediates bypass of the G1/S checkpoint after genotoxic stress in normal human cells
id: 19377290

apoptosome.complex
type: Complex
name: APAF1-CASP9 precursor
data source: Spike
component: APAF1
component: CYCS
component: NLRP1

http://www.ncbi.nlm.nih.gov/#581
type: UnificationXref
db: Entrez Gene
id: 581

BIRC3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#330
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#5728
type: UnificationXref
db: Entrez Gene
id: 5728

TP73_DNA
type: DnaRegion
entity reference: TP73

http://www.ncbi.nlm.nih.gov/#8626
type: UnificationXref
db: Entrez Gene
id: 8626

MYC
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4609
organism: Homo sapiens

BIRC3_RNA
type: RnaRegion
entity reference: BIRC3

RELA
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5970
organism: Homo sapiens

21741842
type: PublicationXref
db: PubMed
title: miRNA response to DNA damage
id: 21741842

MAPK1
type: Protein
entity reference: MAPK1

DIABLO
type: Protein
entity reference: DIABLO

MAPKAPK5
type: Protein
entity reference: MAPKAPK5

TP63
type: Protein
entity reference: TP63

http://www.ncbi.nlm.nih.gov/#27429
type: UnificationXref
db: Entrez Gene
id: 27429

17581882
type: PublicationXref
db: PubMed
title: Cleavage of the transactivation-inhibitory domain of p63 by caspases enhances apoptosis
id: 17581882

TNFRSF10B_inactive
type: Protein
entity reference: TNFRSF10B

.TNFRSF1A.PROMOTES.RIPK1.
type: Catalysis
xref: 8612133
controlled: Physical.Interaction.P.TNFRSF1A.RIPK1
data source: Spike
control type: ACTIVATION
controller: TNFRSF1A

TNFRSF10A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8797
organism: Homo sapiens

APAF1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#317
organism: Homo sapiens

10644043
type: PublicationXref
db: PubMed
title: Suppression of lipopolysaccharide-induced nuclear factor-kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages
id: 10644043

18193389
type: PublicationXref
db: PubMed
title: Interaction of aging-associated signaling cascades: inhibition of NF-kappaB signaling by longevity factors FoxOs and SIRT1
id: 18193389

9933567
type: PublicationXref
db: PubMed
title: Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/c-Jun-amino-terminal kinase interacting protein-1 (JIP-1) gene
id: 9933567

11165042
type: PublicationXref
db: PubMed
title: Activation of mitogen-activated protein kinase phosphatase 2 by gonadotropin-releasing hormone
id: 11165042

DUSP1_DNA
type: DnaRegion
entity reference: DUSP1

18161752
type: PublicationXref
db: PubMed
title: TNF-mediated inflammatory disease
id: 18161752

18285803
type: PublicationXref
db: PubMed
title: Regulation of DNA repair throughout the cell cycle
id: 18285803

MAPK3_inactive
type: Protein
entity reference: MAPK3

.TNFAIP3.INHIBITS.Complex.IKK...(IKBKB).
type: Catalysis
xref: 16684768
controlled: Physical.Interaction.I.TNFAIP3.IKK
data source: Spike
control type: INHIBITION
controller: TNFAIP3

BID
type: Protein
entity reference: BID

9880531
type: PublicationXref
db: PubMed
title: The role of c-FLIP in modulation of CD95-induced apoptosis
id: 9880531

TP53
type: Protein
entity reference: TP53

12042762
type: PublicationXref
db: PubMed
title: IAP proteins: blocking the road to death's door
id: 12042762

.CASP8.PROMOTES.CASP6.
type: Catalysis
xref: 18329793
controlled: Other.P.CASP8.CASP6
data source: Spike
control type: ACTIVATION
controller: CASP8

9104825
type: PublicationXref
db: PubMed
title: Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis
id: 9104825

.MIR504.INHIBITS.TP53.
type: Catalysis
xref: 21741842
xref: 20542001
controlled: mRNA.stability.I.MIR504.TP53
data source: Spike
control type: INHIBITION
controller: MIR504

BIRC3_DNA
type: DnaRegion
entity reference: BIRC3

12198137
type: PublicationXref
db: PubMed
title: Bcl-XL protects BimEL-induced Bax conformational change and cytochrome C release independent of interacting with Bax or BimEL
id: 12198137

MKK4/7.family_inactive
type: Protein

TNFR-Signalosome.complex_RNA
type: RnaRegion

http://www.ncbi.nlm.nih.gov/#5606
type: UnificationXref
db: Entrez Gene
id: 5606

11714700
type: PublicationXref
db: PubMed
title: Transcriptional repression of the anti-apoptotic survivin gene by wild type p53
id: 11714700

http://www.ncbi.nlm.nih.gov/#5609
type: UnificationXref
db: Entrez Gene
id: 5609

PTEN_DNA
type: DnaRegion
entity reference: PTEN

9765224
type: PublicationXref
db: PubMed
title: Pro-caspase-3 is a major physiologic target of caspase-8
id: 9765224

NFkB.complex
type: Complex
name: Nuclear factor kappa-B
data source: Spike
component: RELA

MAP2K4
type: Protein
entity reference: MAP2K4

.E2F1.PROMOTES.TP73.
type: TemplateReactionRegulation
control type: ACTIVATION
xref: 11988839
xref: 17488475
controller: E2F1
controlled: Transcription.Regulation.P.E2F1.TP73
data source: Spike

.PTEN.INHIBITS.Complex.NFkB..RELA..
type: Catalysis
xref: 14729949
controlled: Indirect.I.PTEN.NFkB
data source: Spike
control type: INHIBITION
controller: PTEN

PI3K.complex
type: Complex
name: Class I phosphoinositide-3-kinase
data source: Spike
component: PIK3CA

XAF1
type: Protein
entity reference: XAF1

.CASP8.PROMOTES.CASP7.
type: Catalysis
xref: 18329793
controlled: Other.P.CASP8.CASP7
data source: Spike
control type: ACTIVATION
controller: CASP8

BMF
type: Protein
entity reference: BMF

.PIK3CA.PROMOTES.Family.Akt..AKT1..
type: Catalysis
xref: 15505410
xref: 9561851
xref: 17053865
controlled: Other.P.PIK3CA.Akt
data source: Spike
control type: ACTIVATION
controller: PIK3CA

http://www.ncbi.nlm.nih.gov/#56616
type: UnificationXref
db: Entrez Gene
id: 56616

.FAS.PROMOTES.FADD.
type: Catalysis
xref: 8967952
xref: 7536190
xref: 7538907
controlled: Physical.Interaction.P.FAS.FADD
data source: Spike
control type: ACTIVATION
controller: FAS

11331603
type: PublicationXref
db: PubMed
title: ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage
id: 11331603

9111042
type: PublicationXref
db: PubMed
title: A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members
id: 9111042

18329793
type: PublicationXref
db: PubMed
title: TRAIL and cancer therapy
id: 18329793

XIAP_inactive
type: Protein
entity reference: XIAP

APIP
type: Protein
entity reference: APIP

FAS_RNA
type: RnaRegion
entity reference: FAS

12384981
type: PublicationXref
db: PubMed
title: Regulation of life and death by the zinc finger transcription factor Egr-1
id: 12384981

MAP3K5_inactive
type: Protein
entity reference: MAP3K5

.TNF.PROMOTES.TNFRSF1A.
type: Catalysis
xref: 10634209
xref: 19442713
xref: 2158863
controlled: Physical.Interaction.P.TNF.TNFRSF1A
data source: Spike
control type: ACTIVATION
controller: TNF

9395281
type: PublicationXref
db: PubMed
title: Ras-like GTPases
id: 9395281

APAF1_DNA
type: DnaRegion
entity reference: APAF1

.AKT1.PROMOTES.MDM2.
type: Catalysis
xref: 15169778
controlled: Phosphorylation.P.AKT1.MDM2
data source: Spike
control type: ACTIVATION
controller: AKT1

BIRC5
type: Protein
entity reference: BIRC5

18391971
type: PublicationXref
db: PubMed
title: FOXO-binding partners: it takes two to tango
id: 18391971

16122426
type: PublicationXref
db: PubMed
title: Proapoptotic BID is an ATM effector in the DNA-damage response
id: 16122426

9390557
type: PublicationXref
db: PubMed
title: Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
id: 9390557

16122425
type: PublicationXref
db: PubMed
title: A role for proapoptotic BID in the DNA-damage response
id: 16122425

MAPK8
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5599
organism: Homo sapiens

15184909
type: PublicationXref
db: PubMed
title: Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas
id: 15184909

Translation
type: MolecularInteraction
participant: PTEN_inactive
participant: PTEN_RNA

9742125
type: PublicationXref
db: PubMed
title: Mutagenesis of the BH3 domain of BAX identifies residues critical for dimerization and killing
id: 9742125

MKK4/7.family
type: Protein
xref: ELK:F.329911
data source: Spike
member physical entity: MAP2K4
member physical entity: MAP2K7

http://www.ncbi.nlm.nih.gov/#8837
type: UnificationXref
db: Entrez Gene
id: 8837

TNFRSF10C
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8794
organism: Homo sapiens

MAPK8_inactive
type: Protein
entity reference: MAPK8

.TRADD.PROMOTES.FADD.
type: Catalysis
xref: 8565075
controlled: Physical.Interaction.P.TRADD.FADD
data source: Spike
control type: ACTIVATION
controller: TRADD

DAPK1_inactive
type: Protein
entity reference: DAPK1

7834749
type: PublicationXref
db: PubMed
title: Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
id: 7834749

.RIPK1.PROMOTES.FADD.
type: Catalysis
xref: 11002422
controlled: Physical.Interaction.P.RIPK1.FADD
data source: Spike
control type: ACTIVATION
controller: RIPK1

12402042
type: PublicationXref
db: PubMed
title: BID regulation by p53 contributes to chemosensitivity
id: 12402042

BIRC6
type: Protein
entity reference: BIRC6

MAPK1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5594
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#5604
type: UnificationXref
db: Entrez Gene
id: 5604

PhysicalInteraction [MAP2K3 -- MAPK14 ]
type: MolecularInteraction
xref: 17255949
xref: 16189514
participant: MAP2K3
participant: MAPK14

TP63
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8626
organism: Homo sapiens

HBXIP-survivin.complex
type: Complex
name: HBXIP-survivin(birch5)
data source: Spike
component: BIRC5

BAX
type: Protein
entity reference: BAX

15531749
type: PublicationXref
db: PubMed
title: Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation
id: 15531749

15574335
type: PublicationXref
db: PubMed
title: The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA
id: 15574335

TAU:F.000008
type: UnificationXref
db: Spike DB
id: TAU:F-000008

http://www.ncbi.nlm.nih.gov/#5894
type: UnificationXref
db: Entrez Gene
id: 5894

.DAPK1.PROMOTES.BECN1.
type: Catalysis
xref: 19395874
xref: 19180116
controlled: Phosphorylation.P.DAPK1.BECN1
data source: Spike
control type: ACTIVATION
controller: DAPK1

17008315
type: PublicationXref
db: PubMed
title: Activation of STAT3 by G alpha(s) distinctively requires protein kinase A, JNK, and phosphatidylinositol 3-kinase
id: 17008315

PDPK1_inactive
type: Protein
entity reference: PDPK1

.Family.JNK..MAPK8..PROMOTES.EGR1.
type: Catalysis
xref: 11165042
controlled: N/A.P.JNK.EGR1
data source: Spike
control type: ACTIVATION
controller: JNK.family

11002422
type: PublicationXref
db: PubMed
title: Activation of death-inducing signaling complex (DISC) by pro-apoptotic C-terminal fragment of RIP
id: 11002422

TNFRSF10B
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8795
organism: Homo sapiens

CDKN1B
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1027
organism: Homo sapiens

CASP10
type: Protein
entity reference: CASP10

TRIM28_inactive
type: Protein
entity reference: TRIM28

BIRC2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#329
organism: Homo sapiens

PTPN6
type: Protein
entity reference: PTPN6

.MAPK3.PROMOTES.DAPK1.
type: Catalysis
xref: 15616583
controlled: Phosphorylation.P.MAPK3.DAPK1
data source: Spike
control type: ACTIVATION
controller: MAPK3

JUND_inactive
type: Protein
entity reference: JUND

PRKCZ
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5590
organism: Homo sapiens

.CASP8.PROMOTES.CASP3.
type: Catalysis
xref: 9765224
xref: 11437602
controlled: Proteolytic.Processing.P.CASP8.CASP3
data source: Spike
control type: ACTIVATION
controller: CASP8

17911593
type: PublicationXref
db: PubMed
title: Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock
id: 17911593

15538968
type: PublicationXref
db: PubMed
title: Following a TRAIL: update on a ligand and its five receptors
id: 15538968

11238443
type: PublicationXref
db: PubMed
title: Stress-induced inhibition of ERK1 and ERK2 by direct interaction with p38 MAP kinase
id: 11238443

UVRAG-BECN1-PIK3C3.complex_inactive
type: Protein

.TNF.PROMOTES.TNFRSF1B.
type: Catalysis
xref: 15450251
controlled: Physical.Interaction.P.TNF.TNFRSF1B
data source: Spike
control type: ACTIVATION
controller: TNF

MYC_inactive
type: Protein
entity reference: MYC

8967952
type: PublicationXref
db: PubMed
title: NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain
id: 8967952

9545235
type: PublicationXref
db: PubMed
title: IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
id: 9545235

DDIT3_inactive
type: Protein
entity reference: DDIT3

PMAIP1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5366
organism: Homo sapiens

BBC3_DNA
type: DnaRegion
entity reference: BBC3

.Complex.IKK....INHIBITS.Family.IkB....
type: Catalysis
xref: 10644043
controlled: Phosphorylation.I.IKK.IkB
data source: Spike
control type: INHIBITION
controller: IKK.complex

http://www.ncbi.nlm.nih.gov/#7128
type: UnificationXref
db: Entrez Gene
id: 7128

E2F1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1869
organism: Homo sapiens

.BIRC2.INHIBITS.TRAF2.
type: Catalysis
xref: 11907583
controlled: Ubiquitination.I.BIRC2.TRAF2
data source: Spike
control type: INHIBITION
controller: BIRC2

.TP53.PROMOTES.APAF1.
type: TemplateReactionRegulation
control type: ACTIVATION
xref: 11559530
xref: 11389439
xref: 11423996
controller: TP53
controlled: Transcription.Regulation.P.TP53.APAF1
data source: Spike

8394352
type: PublicationXref
db: PubMed
title: Activation of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase by G protein and tyrosine kinase oncoproteins
id: 8394352

BCL2A1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#597
organism: Homo sapiens

11389439
type: PublicationXref
db: PubMed
title: Apaf-1 is a transcriptional target for E2F and p53
id: 11389439

.CASP3.PROMOTES.CASP9.
type: Catalysis
xref: 8900201
controlled: Proteolytic.Processing.P.CASP3.CASP9
data source: Spike
control type: ACTIVATION
controller: CASP3

http://www.ncbi.nlm.nih.gov/#7124
type: UnificationXref
db: Entrez Gene
id: 7124

.BBC3.INHIBITS.BCL2A1.
type: Catalysis
xref: 15694340
controlled: Physical.Interaction.I.BBC3.BCL2A1
data source: Spike
control type: INHIBITION
controller: BBC3

BCL2A1_inactive
type: Protein
entity reference: BCL2A1

JUND
type: Protein
entity reference: JUND

9626657
type: PublicationXref
db: PubMed
title: Stimulation of Jun N-terminal kinase (JNK) by gonadotropin-releasing hormone in pituitary alpha T3-1 cell line is mediated by protein kinase C, c-Src, and CDC42
id: 9626657

8565075
type: PublicationXref
db: PubMed
title: TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
id: 8565075

MAP2K3_inactive
type: Protein
entity reference: MAP2K3

.RB1.INHIBITS.E2F1.
type: Catalysis
xref: 17488475
controlled: Physical.Interaction.I.RB1.E2F1
data source: Spike
control type: INHIBITION
controller: RB1

GSPT1
type: Protein
entity reference: GSPT1

2158863
type: PublicationXref
db: PubMed
title: Molecular cloning and expression of a receptor for human tumor necrosis factor
id: 2158863

.EGFR.PROMOTES.MAP2K1.
type: Catalysis
xref: 15531749
controlled: Phosphorylation.P.EGFR.MAP2K1
data source: Spike
control type: ACTIVATION
controller: EGFR

IkB.family_inactive
type: Protein

9488720
type: PublicationXref
db: PubMed
title: Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex
id: 9488720

PTEN_RNA
type: RnaRegion
entity reference: PTEN

8681376
type: PublicationXref
db: PubMed
title: Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
id: 8681376

CDKN2A_RNA
type: RnaRegion
entity reference: CDKN2A

MAPK14
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1432
organism: Homo sapiens

RAF1_inactive
type: Protein
entity reference: RAF1

.ATM.PROMOTES.TRIM28.
type: Catalysis
xref: 18285803
controlled: Phosphorylation.P.ATM.TRIM28
data source: Spike
control type: ACTIVATION
controller: ATM

ELK:F.329911
type: UnificationXref
db: Spike DB
id: ELK:F-329911

16341064
type: PublicationXref
db: PubMed
title: Exploiting the PI3K/AKT pathway for cancer drug discovery
id: 16341064

.TP53.INHIBITS.BIRC3.
type: TemplateReactionRegulation
control type: INHIBITION
xref: 16917513
controller: TP53
controlled: Transcription.Regulation.I.TP53.BIRC3
data source: Spike

7774019
type: PublicationXref
db: PubMed
title: Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
id: 7774019

http://www.ncbi.nlm.nih.gov/#54205
type: UnificationXref
db: Entrez Gene
id: 54205

.BAX.PROMOTES.AIFM1.
type: Catalysis
xref: 12232790
controlled: Indirect.P.BAX.AIFM1
data source: Spike
control type: ACTIVATION
controller: BAX

RAF1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5894
organism: Homo sapiens

PIK3CA
type: Protein
entity reference: PIK3CA

http://www.ncbi.nlm.nih.gov/#7132
type: UnificationXref
db: Entrez Gene
id: 7132

http://www.ncbi.nlm.nih.gov/#7133
type: UnificationXref
db: Entrez Gene
id: 7133

IAP-fam.family_inactive
type: Protein

11907583
type: PublicationXref
db: PubMed
title: TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
id: 11907583

PRKCA
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5578
organism: Homo sapiens

NLRP1
type: Protein
entity reference: NLRP1

MAP2K7_inactive
type: Protein
entity reference: MAP2K7

.DAPK1.INHIBITS.MAPK3.
type: Catalysis
xref: 15616583
controlled: Phosphorylation.I.DAPK1.MAPK3
data source: Spike
control type: INHIBITION
controller: DAPK1

.FASLG.PROMOTES.FAS.
type: Catalysis
xref: 9228058
xref: 9126929
controlled: Physical.Interaction.P.FASLG.FAS
data source: Spike
control type: ACTIVATION
controller: FASLG

11283254
type: PublicationXref
db: PubMed
title: Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress
id: 11283254

ERCC6
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2074
organism: Homo sapiens

11546872
type: PublicationXref
db: PubMed
title: Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis
id: 11546872

APAF1_inactive
type: Protein
entity reference: APAF1

SIRT1
type: Protein
entity reference: SIRT1

12232790
type: PublicationXref
db: PubMed
title: The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet
id: 12232790

TNFRSF1A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7132
organism: Homo sapiens

Translation
type: MolecularInteraction
participant: BAX_RNA
participant: BAX_inactive

.PTEN.INHIBITS.Complex.PI3K..PIK3CA..
type: Catalysis
xref: 16540633
controlled: Physical.Interaction.I.PTEN.PI3K
data source: Spike
control type: INHIBITION
controller: PTEN

.MIR155HG.INHIBITS.RIPK1.
type: Catalysis
xref: 17911593
controlled: N/A.I.MIR155HG.RIPK1
data source: Spike
control type: INHIBITION
controller: MIR155HG

.DIABLO.INHIBITS.XIAP.
type: Catalysis
xref: 17560374
xref: 10929712
controlled: Physical.Interaction.I.DIABLO.XIAP
data source: Spike
control type: INHIBITION
controller: DIABLO

BBC3_RNA
type: RnaRegion
entity reference: BBC3

CFLAR
type: Protein
entity reference: CFLAR

BCL2
type: Protein
entity reference: BCL2

PTPN6
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5777
organism: Homo sapiens

9561851
type: PublicationXref
db: PubMed
title: Mechanisms and consequences of activation of protein kinase B/Akt
id: 9561851

TNFRSF1A
type: Protein
entity reference: TNFRSF1A

http://www.ncbi.nlm.nih.gov/#10018
type: UnificationXref
db: Entrez Gene
id: 10018

.JUNB.INHIBITS.BCL2L1.
type: TemplateReactionRegulation
control type: INHIBITION
xref: 11163237
controller: JUNB
controlled: Transcription.Regulation.I.JUNB.BCL2L1
data source: Spike

9314565
type: PublicationXref
db: PubMed
title: Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family
id: 9314565

BCL2A1
type: Protein
entity reference: BCL2A1

.BIRC6.INHIBITS.CASP7.
type: Catalysis
xref: 15200957
controlled: Physical.Interaction.I.BIRC6.CASP7
data source: Spike
control type: INHIBITION
controller: BIRC6

.DIABLO.INHIBITS.Family.IAP.fam..BIRC2,.BIRC3,.XIAP,.BIRC5,.BIRC6..
type: Catalysis
xref: 12209154
controlled: Physical.Interaction.I.DIABLO.IAP.fam
data source: Spike
control type: INHIBITION
controller: DIABLO

MAP3K11_inactive
type: Protein
entity reference: MAP3K11

BAX_inactive
type: Protein
entity reference: BAX

.BCL2L2.INHIBITS.BAK1.
type: Catalysis
xref: 15901672
xref: 18178565
xref: 10381646
controlled: Physical.Interaction.I.BCL2L2.BAK1
data source: Spike
control type: INHIBITION
controller: BCL2L2

CASP9
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#842
organism: Homo sapiens

.DAPK1.INHIBITS.MAPK1.
type: Catalysis
xref: 15616583
controlled: Phosphorylation.I.DAPK1.MAPK1
data source: Spike
control type: INHIBITION
controller: DAPK1

BAX_DNA
type: DnaRegion
entity reference: BAX

PARP1
type: Protein
entity reference: PARP1

12947395
type: PublicationXref
db: PubMed
title: MAPK pathways in radiation responses
id: 12947395

MIR155HG
type: Protein
entity reference: MIR155HG

TAU:F.329942
type: UnificationXref
db: Spike DB
id: TAU:F-329942

.PTPN6.INHIBITS.Family.JNK..MAPK8..
type: Catalysis
xref: 21357539
controlled: Dephosphorylation.I.PTPN6.JNK
data source: Spike
control type: INHIBITION
controller: PTPN6

BBC3
type: Protein
entity reference: BBC3

ERK.family_inactive
type: Protein

17724081
type: PublicationXref
db: PubMed
title: Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1
id: 17724081

.TP73.PROMOTES.BBC3.
type: TemplateReactionRegulation
control type: ACTIVATION
xref: 19788416
controller: TP73
controlled: Transcription.Regulation.P.TP73.BBC3
data source: Spike

.Complex.DISC..TNFRSF10A,.RIPK1,.TRADD,.TRAF2,.TNFRSF1A..PROMOTES.Complex.secondary.DISC..FADD,.CASP8,.CASP10.(FADD).
type: Catalysis
xref: 18471544
controlled: Physical.Interaction.P.DISC.secondary.DISC
data source: Spike
control type: ACTIVATION
controller: DISC.complex

.BAK1.PROMOTES.CYCS.
type: Catalysis
xref: 12232790
xref: 11326099
controlled: Indirect.P.BAK1.CYCS
data source: Spike
control type: ACTIVATION
controller: BAK1

.DAPK1.PROMOTES.CDKN2A.
type: Catalysis
xref: 11146619
controlled: Indirect.P.DAPK1.CDKN2A
data source: Spike
control type: ACTIVATION
controller: DAPK1

http://www.ncbi.nlm.nih.gov/#1958
type: UnificationXref
db: Entrez Gene
id: 1958

http://www.ncbi.nlm.nih.gov/#1956
type: UnificationXref
db: Entrez Gene
id: 1956

.MYC.INHIBITS.PMAIP1.
type: TemplateReactionRegulation
control type: INHIBITION
xref: 15856024
controller: MYC
controlled: Transcription.Regulation.I.MYC.PMAIP1
data source: Spike

15450251
type: PublicationXref
db: PubMed
title: Ligands working as receptors: reverse signaling by members of the TNF superfamily enhance the plasticity of the immune system
id: 15450251

FAS
type: Protein
entity reference: FAS

.PRKCA.PROMOTES.MAPK3.
type: Catalysis
xref: 19074803
controlled: Indirect.P.PRKCA.MAPK3
data source: Spike
control type: ACTIVATION
controller: PRKCA

PI3K.complex_inactive
type: Protein

TNFAIP3
type: Protein
entity reference: TNFAIP3

DIABLO
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#56616
organism: Homo sapiens

DDIT3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1649
organism: Homo sapiens

15944736
type: PublicationXref
db: PubMed
title: TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria
id: 15944736

FASLG
type: Protein
entity reference: FASLG

TP53_RNA
type: RnaRegion
entity reference: TP53

XIAP
type: Protein
entity reference: XIAP

16917513
type: PublicationXref
db: PubMed
title: Hypoxia induces p53-dependent transactivation and Fas/CD95-dependent apoptosis
id: 16917513

TNFRSF10D
type: Protein
entity reference: TNFRSF10D

.MAPK8.PROMOTES.BAX.
type: Catalysis
xref: 18471544
controlled: Phosphorylation.P.MAPK8.BAX
data source: Spike
control type: ACTIVATION
controller: MAPK8