Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
The phosphatase SRC homology region 2 domain-containing phosphatase-1 is an intrinsic central regulator of dendritic cell function
HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter
The B cell antigen receptor activates the Akt (protein kinase B)/glycogen synthase kinase-3 signaling pathway via phosphatidylinositol 3-kinase
The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32
A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain
Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction
Dexamethasone protects auditory hair cells against TNFalpha-initiated apoptosis via activation of PI3K/Akt and NFkappaB signaling
Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection
The phosphoinositide 3-kinase/Akt1/Par-4 axis: a cancer-selective therapeutic target
Mxi2 promotes stimulus-independent ERK nuclear translocation
TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex
NF-kappaB Signaling in the Aging Process
MKP-1 represses JNK-mediated apoptosis via NF-kappa B regulation
Exogenous nitric oxide stimulates cell proliferation via activation of a mitogen-activated protein kinase pathway in ovine fetoplacental artery endothelial cells
Involvement of two NF-kappa B binding elements in tumor necrosis factor alpha -, CD40-, and epstein-barr virus latent membrane protein 1-mediated induction of the cIAP2
Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner
The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression
DISC (Primary complex) FADD, CASP8, CASP10
A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death
E2F1 death pathways as targets for cancer therapy
TGF- Promotes Proliferation of Thyroid Epithelial Cells in IFN-(-/-) Mice by Down-Regulation of p21 and p27 via AKT Pathway
The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation
Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2
The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4
Negative regulation of the Apaf-1 apoptosome by Hsp70
Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation
Overview of cell death signaling pathways
Suppression of PTEN expression by NF-kappa B prevents apoptosis
Apoptosis signal-regulating kinase 1 (ASK1) is an intracellular inducer of keratinocyte differentiation
Rapid activation of Stat3 and ERK1/2 by nicotine modulates cell proliferation in human bladder cancer cells
Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation
Inhibition of the Jun N-terminal protein kinase pathway by SHIP-1, a lipid phosphatase that interacts with the adaptor molecule Dok-3
Ubiquitylation of MEKK1 inhibits its phosphorylation of MKK1 and MKK4 and activation of the ERK1/2 and JNK pathways
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization
Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members
Onzin, a c-Myc-repressed target, promotes survival and transformation by modulating the Akt-Mdm2-p53 pathway
The intracellular signal transduction mechanism of interleukin 5 in eosinophils: the involvement of lyn tyrosine kinase and the Ras-Raf-1-MEK-microtubule-associated protein kinase pathway
Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM
PUMA mediates the apoptotic response to p53 in colorectal cancer cells
RIP1, TRAF2, NEMO, FADD, TRADD, caspase-8 caspase-10
Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling - roles of p53, p73 and HIPK2
Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression
PRAK, a novel protein kinase regulated by the p38 MAP kinase
Characterization of Fas (Apo-1, CD95)-Fas ligand interaction
Role of protein kinase C zeta isoform in Fas resistance of immature myeloid KG1a leukemic cells
X-linked IAP is a direct inhibitor of cell-death proteases
Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation
IAP family proteins--suppressors of apoptosis
Nonionic detergents induce dimerization among members of the Bcl-2 family
A PI3K pathway mediates hair cell survival and opposes gentamicin toxicity in neonatal rat organ of Corti
Regulation of Btk function by a major autophosphorylation site within the SH3 domain
MEKK1-induced apoptosis requires TRAIL death receptor activation and is inhibited by AKT/PKB through inhibition of MEKK1 cleavage
Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein
Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells
Cellular and molecular mechanisms of liver injury
The C terminus of p53 binds the N-terminal domain of MDM2
Regulation of cell death protease caspase-9 by phosphorylation
Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-X(L)
The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy
Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK
Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death
Stress-inducible transcription factor CHOP/gadd153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanisms
Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK
Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis
Phospholipase C-gamma 2 couples Bruton's tyrosine kinase to the NF-kappaB signaling pathway in B lymphocytes
Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family
The Bcl2 family: regulators of the cellular life-or-death switch
dapk1, encoding an activator of a p19ARF-p53-mediated apoptotic checkpoint, is a transcription target of p53
Transcriptional regulation of the human tumor suppressor p14(ARF) by E2F1, E2F2, E2F3, and Sp1-like factors
IL-2 activation of a PI3K-dependent STAT3 serine phosphorylation pathway in primary human T cells
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
Stimulatory role of PKCalpha in extracellular regulated kinase 1/2 pathway in conjunctival goblet cell proliferation
Peroxynitrite induces GADD34, 45, and 153 VIA p38 MAPK in human neuroblastoma SH-SY5Y cells
ATM associates with and phosphorylates p53: mapping the region of interaction
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
Tumor necrosis factor alpha transcription in macrophages is attenuated by an autocrine factor that preferentially induces NF-kappaB p50
The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism
Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis
Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase
Involvement of Ras in Bruton's tyrosine kinase-mediated JNK activation
IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
Towards a proteome-scale map of the human protein-protein interaction network
Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation
Cumulative effect of phosphorylation of pRB on regulation of E2F activity
A comprehensive modular map of molecular interactions in RB/E2F pathway
Identification of amino acid residues important for ligand binding to Fas
Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
PI3K-Akt pathway: its functions and alterations in human cancer
CSB protein is (a direct target of HIF-1 and) a critical mediator of the hypoxic response
ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB
JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis
T cell proliferation in response to interleukins 2 and 7 requires p38MAP kinase activation
The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain
The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites
PRAK is essential for ras-induced senescence and tumor suppression
Importance of PIKKs in NF-B activation by genotoxic stress
Nuclear caspase-3 and caspase-7 activation, and poly(ADP-ribose) polymerase cleavage are early events in camptothecin-induced apoptosis
In vitro selection and characterization of Bcl-X(L)-binding proteins from a mix of tissue-specific mRNA display libraries
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins
ERK1b, a 46-kDa ERK isoform that is differentially regulated by MEK
Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
Efficient activation of p53 pathway in A549 cells exposed to L2, a novel compound targeting p53-MDM2 interaction
DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1
Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
Selective progesterone receptor modulator asoprisnil induces endoplasmic reticulum stress in cultured human uterine leiomyoma cells
Chronic myeloid leukemia with increased granulocyte progenitors in mice lacking junB expression in the myeloid lineage
[W206R]-procaspase 3: an inactivatable substrate for caspase 8
Involvement of JNK regulation in oxidative stress-mediated murine liver injury by microcystin-LR
Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases
PUMA, a novel proapoptotic gene, is induced by p53
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
Secretase-dependent tyrosine phosphorylation of Mdm2 by the ErbB-4 intracellular domain fragment
Differential regulation of Bax and Bak by anti-apoptotic Bcl-2 family proteins Bcl-B and Mcl-1
Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells. Microarray analysis reveals defective induction of p53 target genes and upregulation of chaperone genes
Phosphorylation of mitogen-activated protein kinase 8 (MAPK8) is associated with germ cell apoptosis and redistribution of the Bcl2-modifying factor (BMF)
Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)
A single BIR domain of XIAP sufficient for inhibiting caspases
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c
Cockayne syndrome B protein (CSB): linking p53, HIF-1 and p300 to robustness, lifespan, cancer and cell fate decisions
The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
Enhanced phosphorylation of p53 by ATM in response to DNA damage
DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation
Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
Investigation of the proapoptotic BCL-2 family member bid on the crossroad of the DNA damage response and apoptosis
Transcriptional control of human p53-regulated genes
APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis
Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria
XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization
BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
The human p73 promoter: characterization and identification of functional E2F binding sites
DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy
An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7
Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin
Divorcing ARF and p53: an unsettled case
X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes
Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence
ER stress triggers apoptosis by activating BH3-only protein Bim
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
AKT1 mediates bypass of the G1/S checkpoint after genotoxic stress in normal human cells
Cleavage of the transactivation-inhibitory domain of p63 by caspases enhances apoptosis
Suppression of lipopolysaccharide-induced nuclear factor-kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages
Interaction of aging-associated signaling cascades: inhibition of NF-kappaB signaling by longevity factors FoxOs and SIRT1
Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/c-Jun-amino-terminal kinase interacting protein-1 (JIP-1) gene
Activation of mitogen-activated protein kinase phosphatase 2 by gonadotropin-releasing hormone
Regulation of DNA repair throughout the cell cycle
The role of c-FLIP in modulation of CD95-induced apoptosis
IAP proteins: blocking the road to death's door
Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis
Bcl-XL protects BimEL-induced Bax conformational change and cytochrome C release independent of interacting with Bax or BimEL
Transcriptional repression of the anti-apoptotic survivin gene by wild type p53
Pro-caspase-3 is a major physiologic target of caspase-8
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage
A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members
Regulation of life and death by the zinc finger transcription factor Egr-1
FOXO-binding partners: it takes two to tango
Proapoptotic BID is an ATM effector in the DNA-damage response
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
A role for proapoptotic BID in the DNA-damage response
Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas
Mutagenesis of the BH3 domain of BAX identifies residues critical for dimerization and killing
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
BID regulation by p53 contributes to chemosensitivity
Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation
The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA
Activation of STAT3 by G alpha(s) distinctively requires protein kinase A, JNK, and phosphatidylinositol 3-kinase
Activation of death-inducing signaling complex (DISC) by pro-apoptotic C-terminal fragment of RIP
Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock
Following a TRAIL: update on a ligand and its five receptors
Stress-induced inhibition of ERK1 and ERK2 by direct interaction with p38 MAP kinase
NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain
IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
Activation of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase by G protein and tyrosine kinase oncoproteins
Apaf-1 is a transcriptional target for E2F and p53
Stimulation of Jun N-terminal kinase (JNK) by gonadotropin-releasing hormone in pituitary alpha T3-1 cell line is mediated by protein kinase C, c-Src, and CDC42
TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
Molecular cloning and expression of a receptor for human tumor necrosis factor
Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex
Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
Exploiting the PI3K/AKT pathway for cancer drug discovery
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress
Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis
The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet
Mechanisms and consequences of activation of protein kinase B/Akt
Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family
Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1
Ligands working as receptors: reverse signaling by members of the TNF superfamily enhance the plasticity of the immune system
TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria
Hypoxia induces p53-dependent transactivation and Fas/CD95-dependent apoptosis