.DAPK1.INHIBITS.TSC2.
type: Catalysis
data source: Spike
xref: 18974095
controller: DAPK1
control type: INHIBITION
controlled: Phosphorylation.I.DAPK1.TSC2

.EPO.PROMOTES.DAPK2.
type: Catalysis
data source: Spike
xref: 18535204
controller: EPO
control type: ACTIVATION
controlled: Indirect.P.EPO.DAPK2

.CTNNB1.INHIBITS.DAPK2.
type: TemplateReactionRegulation
xref: 18957423
data source: Spike
control type: INHIBITION
controller: CTNNB1
controlled: Transcription.Regulation.I.CTNNB1.DAPK2

http://www.ncbi.nlm.nih.gov/#4131
type: UnificationXref
db: Entrez Gene
id: 4131

http://www.ncbi.nlm.nih.gov/#7094
type: UnificationXref
db: Entrez Gene
id: 7094

EPO
type: Protein
entity reference: EPO

CDKN1A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1026

SMAD3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4088

SMAD2
type: Protein
entity reference: SMAD2

BCL2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#596

11485996
type: PublicationXref
title: Identification of a new form of death-associated protein kinase that promotes cell survival
db: PubMed
id: 11485996

HSP90AA1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3320

filamentous actin
type: Complex
data source: Spike
display name: f-actin.complex

DAPK1
type: Protein
entity reference: DAPK1

15002035
type: PublicationXref
title: DAP-kinase-mediated morphological changes are localization dependent and involve myosin-II phosphorylation
db: PubMed
id: 15002035

SMAD4
type: Protein
entity reference: SMAD4

interferon (IFN)-gamma-activated inhibitor of translation
type: Complex
data source: Spike
component: RPL13A
display name: GAIT complex.complex

AR_inactive
type: Protein
entity reference: AR

.DAPK3.INHIBITS.RPL13A.
type: Catalysis
data source: Spike
xref: 18995835
controller: DAPK3
control type: INHIBITION
controlled: Phosphorylation.I.DAPK3.RPL13A

18583991
type: PublicationXref
title: Neogenin regulates neuronal survival through DAP kinase
db: PubMed
id: 18583991

.PTPRF.PROMOTES.DAPK1.
type: Catalysis
data source: Spike
xref: 17803936
controller: PTPRF
control type: ACTIVATION
controlled: Dephosphorylation.P.PTPRF.DAPK1

19579266
type: PublicationXref
title: Efficient activation of p53 pathway in A549 cells exposed to L2, a novel compound targeting p53-MDM2 interaction
db: PubMed
id: 19579266

.DAPK3.PROMOTES.PPP1R14A.
type: Catalysis
data source: Spike
xref: 11287002
controller: DAPK3
control type: ACTIVATION
controlled: Dephosphorylation.P.DAPK3.PPP1R14A

STX1A
type: Protein
entity reference: STX1A

STX1A_inactive
type: Protein
entity reference: STX1A

18806755
type: PublicationXref
title: DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death
db: PubMed
id: 18806755

myosin phosphatase
type: Complex
data source: Spike
component: PPP1R12A
display name: myosin phosphatase.complex

TP53
type: Protein
entity reference: TP53

17337444
type: PublicationXref
title: Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein
db: PubMed
id: 17337444

MCM3
type: Protein
entity reference: MCM3

NR3C1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2908

RPL13A
type: Protein
entity reference: RPL13A

http://www.ncbi.nlm.nih.gov/#57534
type: UnificationXref
db: Entrez Gene
id: 57534

http://www.ncbi.nlm.nih.gov/#8678
type: UnificationXref
db: Entrez Gene
id: 8678

18957423
type: PublicationXref
title: Down-regulation of death-associated protein kinase-2 is required for beta-catenin-induced anoikis resistance of malignant epithelial cells
db: PubMed
id: 18957423

CDKN2A_inactive
type: Protein
entity reference: CDKN2A

SRC
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6714

PPP1R12A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4659

SMAD3
type: Protein
entity reference: SMAD3

18974095
type: PublicationXref
title: Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase (DAPK) death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling
db: PubMed
id: 18974095

16179260
type: PublicationXref
title: Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
db: PubMed
id: 16179260

CTNNB1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1499

19118212
type: PublicationXref
title: Integrins in cell migration--the actin connection
db: PubMed
id: 19118212

DAPK2_RNA
type: RnaRegion
entity reference: DAPK2

http://www.ncbi.nlm.nih.gov/#6804
type: UnificationXref
db: Entrez Gene
id: 6804

.DAPK1.PROMOTES.TPM1.
type: Catalysis
data source: Spike
xref: 17895359
controller: DAPK1
control type: ACTIVATION
controlled: Phosphorylation.P.DAPK1.TPM1

WSC:F.000019
type: UnificationXref
db: Spike DB
id: WSC:F-000019

myosin II
type: Complex
data source: Spike
component: RLC (nonmuscle).family
display name: myosin II.complex

http://www.ncbi.nlm.nih.gov/#5792
type: UnificationXref
db: Entrez Gene
id: 5792

WSC:F.000018
type: UnificationXref
db: Spike DB
id: WSC:F-000018

DAPK3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1613

WSC:F.000017
type: UnificationXref
db: Spike DB
id: WSC:F-000017

11331603
type: PublicationXref
title: ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage
db: PubMed
id: 11331603

NEO1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4756

11740493
type: PublicationXref
title: TGF-beta induces apoptosis through Smad-mediated expression of DAP-kinase
db: PubMed
id: 11740493

.Family.RSK1/2....INHIBITS.DAPK1.
type: Catalysis
data source: Spike
xref: 16213824
controller: RSK1/2.family
control type: INHIBITION
controlled: Phosphorylation.I.RSK1/2.DAPK1

BCL2L1
type: Protein
entity reference: BCL2L1

http://www.ncbi.nlm.nih.gov/#6714
type: UnificationXref
db: Entrez Gene
id: 6714

ROCK1
type: Protein
entity reference: ROCK1

RLC (nonmuscle).family_inactive
type: Protein

CDKN2A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1029

TLN1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7094

RPS6
type: Protein
entity reference: RPS6

ECM.family
type: Protein
data source: Spike
xref: WSC:F.000017

.DAPK3.PROMOTES.CDKN1A.
type: Catalysis
data source: Spike
xref: 15001356
controller: DAPK3
control type: ACTIVATION
controlled: Phosphorylation.P.DAPK3.CDKN1A

.NEO1.PROMOTES.DAPK1.
type: Catalysis
data source: Spike
xref: 18583991
controller: NEO1
control type: ACTIVATION
controlled: Physical.Interaction.P.NEO1.DAPK1

http://www.ncbi.nlm.nih.gov/#1499
type: UnificationXref
db: Entrez Gene
id: 1499

.DAPK1.INHIBITS.CAMKK2.
type: Catalysis
data source: Spike
xref: 15209507
controller: DAPK1
control type: INHIBITION
controlled: Phosphorylation.I.DAPK1.CAMKK2

http://www.ncbi.nlm.nih.gov/#94274
type: UnificationXref
db: Entrez Gene
id: 94274

http://www.ncbi.nlm.nih.gov/#2056
type: UnificationXref
db: Entrez Gene
id: 2056

CTNNB1
type: Protein
entity reference: CTNNB1

17703233
type: PublicationXref
title: DAP kinase regulates JNK signaling by binding and activating protein kinase D under oxidative stress
db: PubMed
id: 17703233

PRKD1
type: Protein
entity reference: PRKD1

17803936
type: PublicationXref
title: The tumor suppressor DAPK is reciprocally regulated by tyrosine kinase Src and phosphatase LAR
db: PubMed
id: 17803936

KLF6
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1316

.Complex.f.actin....PROMOTES.Complex.myosin.II..Family.RLC.(nonmuscle)....(MYH9).
type: Catalysis
data source: Spike
xref: 143236
controller: filamentous actin
control type: ACTIVATION
controlled: Other.P.f.actin.myosin.II

http://www.ncbi.nlm.nih.gov/#6194
type: UnificationXref
db: Entrez Gene
id: 6194

15124925
type: PublicationXref
title: Myosin phosphatase: structure, regulation and function
db: PubMed
id: 15124925

9118961
type: PublicationXref
title: DAP-kinase is a Ca2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity
db: PubMed
id: 9118961

ITGB1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3688

MDM2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4193

http://www.ncbi.nlm.nih.gov/#7157
type: UnificationXref
db: Entrez Gene
id: 7157

DAPK3
type: Protein
entity reference: DAPK3

http://www.ncbi.nlm.nih.gov/#6198
type: UnificationXref
db: Entrez Gene
id: 6198

MDM2_inactive
type: Protein
entity reference: MDM2

http://www.ncbi.nlm.nih.gov/#1869
type: UnificationXref
db: Entrez Gene
id: 1869

.DAPK1.UNKNOWN.STX1A.
type: Catalysis
data source: Spike
xref: 12730201
controller: DAPK1
control type: ACTIVATION_UNKMECH
controlled: Phosphorylation.U.DAPK1.STX1A

.DAPK1.PROMOTES.DAPK3.
type: Catalysis
data source: Spike
xref: 15367680
controller: DAPK1
control type: ACTIVATION
controlled: Phosphorylation.P.DAPK1.DAPK3

RLC (muscle).family_inactive
type: Protein

myosin II.complex_inactive
type: Protein

TLN1
type: Protein
entity reference: TLN1

DAPK2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#23604

Translation
type: MolecularInteraction
participant: DAPK1_RNA
participant: DAPK1_inactive

12172553
type: PublicationXref
title: TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
db: PubMed
id: 12172553

SRC
type: Protein
entity reference: SRC

DAPK1_inactive
type: Protein
entity reference: DAPK1

NR3C1
type: Protein
entity reference: NR3C1

RPS6KB1
type: Protein
entity reference: RPS6KB1

MAP1B
type: Protein
entity reference: MAP1B

EPO
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2056

mTOR complex1
type: Complex
data source: Spike
component: MTOR
display name: mTORC1.complex

14600263
type: PublicationXref
title: Uncoordinated regulation of stress fibers and focal adhesions by DAP kinase
db: PubMed
id: 14600263

20639885
type: PublicationXref
title: The C terminus of p53 binds the N-terminal domain of MDM2
db: PubMed
id: 20639885

http://www.ncbi.nlm.nih.gov/#7168
type: UnificationXref
db: Entrez Gene
id: 7168

19395874
type: PublicationXref
title: Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-X(L)
db: PubMed
id: 19395874

20220139
type: PublicationXref
title: Protein phosphatase 2A (PP2A) holoenzymes regulate death-associated protein kinase (DAPK) in ceramide-induced anoikis
db: PubMed
id: 20220139

TPM1_inactive
type: Protein
entity reference: TPM1

11384979
type: PublicationXref
title: Zipper-interacting protein kinase induces Ca(2+)-free smooth muscle contraction via myosin light chain phosphorylation
db: PubMed
id: 11384979

PRKD1_inactive
type: Protein
entity reference: PRKD1

.E2F1.PROMOTES.DAPK2.
type: TemplateReactionRegulation
xref: 18521079
data source: Spike
control type: ACTIVATION
controller: E2F1
controlled: Transcription.Regulation.P.E2F1.DAPK2

PPP1R14A_inactive
type: Protein
entity reference: PPP1R14A

11230133
type: PublicationXref
title: Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding
db: PubMed
id: 11230133

WSC:F.000004
type: UnificationXref
db: Spike DB
id: WSC:F-000004

11287002
type: PublicationXref
title: Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase
db: PubMed
id: 11287002

.DAPK1.PROMOTES.PRKD1.
type: Catalysis
data source: Spike
xref: 17703233
controller: DAPK1
control type: ACTIVATION
controlled: Phosphorylation.P.DAPK1.PRKD1

.DAPK1.PROMOTES.BECN1.
type: Catalysis
data source: Spike
xref: 19395874
xref: 19180116
controller: DAPK1
control type: ACTIVATION
controlled: Phosphorylation.P.DAPK1.BECN1

CDKN2A
type: Protein
entity reference: CDKN2A

.DAPK1.UNKNOWN.MCM3.
type: Catalysis
data source: Spike
xref: 18283219
controller: DAPK1
control type: ACTIVATION_UNKMECH
controlled: Phosphorylation.U.DAPK1.MCM3

15616583
type: PublicationXref
title: Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK
db: PubMed
id: 15616583

DAPK3_inactive
type: Protein
entity reference: DAPK3

TPM1
type: Protein
entity reference: TPM1

RLC (muscle).family
type: Protein
data source: Spike
xref: WSC:F.000018

BECN1_inactive
type: Protein
entity reference: BECN1

.MIB1.INHIBITS.DAPK1.
type: Catalysis
data source: Spike
xref: 12351649
controller: MIB1
control type: INHIBITION
controlled: Ubiquitination.I.MIB1.DAPK1

UNC5B
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#219699

.Complex.PP2A....PROMOTES.DAPK1.
type: Catalysis
data source: Spike
xref: 20220139
xref: 18806755
controller: Protein phosphatase 2A
control type: ACTIVATION
controlled: Dephosphorylation.P.PP2A.DAPK1

.CDKN2A.INHIBITS.MDM2.
type: Catalysis
data source: Spike
xref: 12209154
xref: 16915296
controller: CDKN2A
control type: INHIBITION
controlled: Physical.Interaction.I.CDKN2A.MDM2

http://www.ncbi.nlm.nih.gov/#3320
type: UnificationXref
db: Entrez Gene
id: 3320

BCL2L1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#598

CDKN1A
type: Protein
entity reference: CDKN1A

CAMKK2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#10645

.DAPK1.INHIBITS.DAPK1.
type: Catalysis
data source: Spike
xref: 11579085
controller: DAPK1
control type: INHIBITION
controlled: Phosphorylation.I.DAPK1.DAPK1

DAPK2_inactive
type: Protein
entity reference: DAPK2

.SRC.INHIBITS.DAPK1.
type: Catalysis
data source: Spike
xref: 17803936
controller: SRC
control type: INHIBITION
controlled: Phosphorylation.I.SRC.DAPK1

.DAPK2.INHIBITS.DAPK2.
type: Catalysis
data source: Spike
xref: 11230133
controller: DAPK2
control type: INHIBITION
controlled: Phosphorylation.I.DAPK2.DAPK2

http://www.ncbi.nlm.nih.gov/#219699
type: UnificationXref
db: Entrez Gene
id: 219699

http://www.ncbi.nlm.nih.gov/#2475
type: UnificationXref
db: Entrez Gene
id: 2475

Myosin (muscle)
type: Complex
data source: Spike
component: RLC (muscle).family
display name: Myosin (muscle).complex

TPM1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7168

15729359
type: PublicationXref
title: The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase
db: PubMed
id: 15729359

LC3 (Atg8/MAP1LC3B) -PE conjugation
type: Complex
data source: Spike
component: MAP1LC3B
display name: LC3-PE.complex

TP53_inactive
type: Protein
entity reference: TP53

RSK1/2.family
type: Protein
data source: Spike
xref: WSC:F.000004

PRKD1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5587

MAP1B
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4131

PPP1R12A_inactive
type: Protein
entity reference: PPP1R12A

MTOR
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2475

Homo sapiens
type: BioSource
xref: 9606

BECN1
type: Protein
entity reference: BECN1

12209154
type: PublicationXref
title: The Bcl2 family: regulators of the cellular life-or-death switch
db: PubMed
id: 12209154

15608685
type: PublicationXref
title: dapk1, encoding an activator of a p19ARF-p53-mediated apoptotic checkpoint, is a transcription target of p53
db: PubMed
id: 15608685

E2F1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1869

8937989
type: PublicationXref
title: Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site
db: PubMed
id: 8937989

.ROCK1.PROMOTES.Family.RLC.(nonmuscle)...(MYL12A).
type: Catalysis
data source: Spike
xref: 11283607
xref: 8702756
controller: ROCK1
control type: ACTIVATION
controlled: Phosphorylation.P.ROCK1.RLC.(nonmuscle)

.DAPK1.INHIBITS.RPS6.
type: Catalysis
data source: Spike
xref: 17087515
controller: DAPK1
control type: INHIBITION
controlled: Phosphorylation.I.DAPK1.RPS6

.PPP1R14A.INHIBITS.Complex.myosin.phosphatase..PPP1R12A.(PPP1CA).
type: Catalysis
data source: Spike
xref: 15124925
controller: PPP1R14A
control type: INHIBITION
controlled: Physical.Interaction.I.PPP1R14A.myosin.phosphatase

STX1A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6804

DAPK2_DNA
type: DnaRegion
entity reference: DAPK2

.TLN1.PROMOTES.ITGB1.
type: Catalysis
data source: Spike
xref: 19118212
controller: TLN1
control type: ACTIVATION
controlled: Physical.Interaction.P.TLN1.ITGB1

ITGB1_inactive
type: Protein
entity reference: ITGB1

Class III PI3K
type: Complex
data source: Spike
component: BECN1
display name: Class III PI3K.complex

SMAD4
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4089

TAU:F.000011
type: UnificationXref
db: Spike DB
id: TAU:F-000011

RPS6
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6194

8702756
type: PublicationXref
title: Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)
db: PubMed
id: 8702756

9606
type: UnificationXref
db: taxonomy
id: 9606

TSC2_inactive
type: Protein
entity reference: TSC2

18195017
type: PublicationXref
title: DAPK-1 binding to a linear peptide motif in MAP1B stimulates autophagy and membrane blebbing
db: PubMed
id: 18195017

UNC5B
type: Protein
entity reference: UNC5B

11283607
type: PublicationXref
title: Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing
db: PubMed
id: 11283607

.DAPK3.PROMOTES.NR3C1.
type: Catalysis
data source: Spike
xref: 18084323
controller: DAPK3
control type: ACTIVATION
controlled: Dephosphorylation.P.DAPK3.NR3C1

CDKN1A_inactive
type: Protein
entity reference: CDKN1A

15367680
type: PublicationXref
title: Death-associated protein kinase phosphorylates ZIP kinase, forming a unique kinase hierarchy to activate its cell death functions
db: PubMed
id: 15367680

12351649
type: PublicationXref
title: A death-associated protein kinase (DAPK)-interacting protein, DIP-1, is an E3 ubiquitin ligase that promotes tumor necrosis factor-induced apoptosis and regulates the cellular levels of DAPK
db: PubMed
id: 12351649

http://www.ncbi.nlm.nih.gov/#3688
type: UnificationXref
db: Entrez Gene
id: 3688

http://www.ncbi.nlm.nih.gov/#10645
type: UnificationXref
db: Entrez Gene
id: 10645

ROCK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6093

http://www.ncbi.nlm.nih.gov/#367
type: UnificationXref
db: Entrez Gene
id: 367

ITGB1
type: Protein
entity reference: ITGB1

.Family.ECM....PROMOTES.Complex.Integrin,.alpha/beta1...(ITGA3).
type: Catalysis
data source: Spike
xref: 9854310
controller: ECM.family
control type: ACTIVATION
controlled: Physical.Interaction.P.ECM.Integrin,.alpha/beta1

TSC2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7249

9854310
type: PublicationXref
title: ECM signalling: orchestrating cell behaviour and misbehaviour
db: PubMed
id: 9854310

http://www.ncbi.nlm.nih.gov/#1026
type: UnificationXref
db: Entrez Gene
id: 1026

MTOR
type: Protein
entity reference: MTOR

.Family.RLC.(nonmuscle)....PROMOTES.Complex.myosin.II..Family.RLC.(nonmuscle)....(MYL6).
type: Catalysis
data source: Spike
xref: 10047526
controller: RLC (nonmuscle).family
control type: ACTIVATION
controlled: Other.P.RLC.(nonmuscle).myosin.II

http://www.ncbi.nlm.nih.gov/#1029
type: UnificationXref
db: Entrez Gene
id: 1029

DAPK2
type: Protein
entity reference: DAPK2

DAPK1_DNA
type: DnaRegion
entity reference: DAPK1

15209507
type: PublicationXref
title: A calmodulin-regulated protein kinase linked to neuron survival is a substrate for the calmodulin-regulated death-associated protein kinase
db: PubMed
id: 15209507

http://www.ncbi.nlm.nih.gov/#5587
type: UnificationXref
db: Entrez Gene
id: 5587

CAMKK2
type: Protein
entity reference: CAMKK2

AR
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#367

.Complex.myosin.phosphatase..PPP1R12A..INHIBITS.Family.RLC.(nonmuscle)...(MYL12A).
type: Catalysis
data source: Spike
xref: 15124925
controller: myosin phosphatase
control type: INHIBITION
controlled: Dephosphorylation.I.myosin.phosphatase.RLC.(nonmuscle)

alpha- /beta1 integrin
type: Complex
data source: Spike
display name: Integrin, alpha/beta1.complex

16551624
type: PublicationXref
title: Hsp90 recognizes a common surface on client kinases
db: PubMed
id: 16551624

http://www.ncbi.nlm.nih.gov/#1613
type: UnificationXref
db: Entrez Gene
id: 1613

RPL13A_inactive
type: Protein
entity reference: RPL13A

11146619
type: PublicationXref
title: DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation
db: PubMed
id: 11146619

MCM3_inactive
type: Protein
entity reference: MCM3

PhysicalInteraction [DAPK1 -- Complex f-actin {} ]
type: MolecularInteraction
xref: 9118961
xref: 15002035
comment: DAPk localizes to the actin cytoskeleton by immunostaining and cell fractionation
participant: filamentous actin
participant: DAPK1

.DAPK1.INHIBITS.Complex.Integrin,.alpha/beta1...(ITGA3).
type: Catalysis
data source: Spike
xref: 12370243
controller: DAPK1
control type: INHIBITION
controlled: Indirect.I.DAPK1.Integrin,.alpha/beta1

MCM3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4172

11579085
type: PublicationXref
title: The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism
db: PubMed
id: 11579085

18283219
type: PublicationXref
title: A high throughput proteomics screen identifies novel substrates of death-associated protein kinase
db: PubMed
id: 18283219

PPP1R12A
type: Protein
entity reference: PPP1R12A

BECN1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8678

.DAPK3.PROMOTES.DAPK3.
type: Catalysis
data source: Spike
xref: 15611134
controller: DAPK3
control type: ACTIVATION
controlled: Phosphorylation.P.DAPK3.DAPK3

http://www.ncbi.nlm.nih.gov/#1316
type: UnificationXref
db: Entrez Gene
id: 1316

.HSP90AA1.PROMOTES.DAPK1.
type: Catalysis
data source: Spike
xref: 16551624
controller: HSP90AA1
control type: ACTIVATION
controlled: Physical.Interaction.P.HSP90AA1.DAPK1

Tuberous sclerosis complex
type: Complex
data source: Spike
component: TSC2
display name: TSC1-TSC2.complex

10047526
type: PublicationXref
title: Molecular mechanisms of nonmuscle myosin-II regulation
db: PubMed
id: 10047526

.MDM2.INHIBITS.TP53.
type: Catalysis
data source: Spike
xref: 11331603
xref: 20639885
xref: 19579266
controller: MDM2
control type: INHIBITION
controlled: Physical.Interaction.I.MDM2.TP53

http://www.ncbi.nlm.nih.gov/#4756
type: UnificationXref
db: Entrez Gene
id: 4756

CAMKK2_inactive
type: Protein
entity reference: CAMKK2

PPP1R14A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#94274

.Family.ERK....PROMOTES.DAPK1.
type: Catalysis
data source: Spike
xref: 15616583
controller: ERK.family
control type: ACTIVATION
controlled: Phosphorylation.P.ERK.DAPK1

12370243
type: PublicationXref
title: DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals
db: PubMed
id: 12370243

10356987
type: PublicationXref
title: ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells
db: PubMed
id: 10356987

11781833
type: PublicationXref
title: HeLa ZIP kinase induces diphosphorylation of myosin II regulatory light chain and reorganization of actin filaments in nonmuscle cells
db: PubMed
id: 11781833

17895359
type: PublicationXref
title: DAP kinase mediates the phosphorylation of tropomyosin-1 downstream of the ERK pathway, which regulates the formation of stress fibers in response to oxidative stress
db: PubMed
id: 17895359

RPS6KB1_inactive
type: Protein
entity reference: RPS6KB1

.Complex.TSC1.TSC2..TSC2..INHIBITS.MTOR.
type: Catalysis
data source: Spike
xref: 12172553
controller: Tuberous sclerosis complex
control type: INHIBITION
controlled: Other.I.TSC1.TSC2.MTOR

MAP1LC3B
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#81631

.MAP1B.PROMOTES.DAPK1.
type: Catalysis
data source: Spike
xref: 18195017
controller: MAP1B
control type: ACTIVATION
controlled: Physical.Interaction.P.MAP1B.DAPK1

RPS6KB1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6198

http://www.ncbi.nlm.nih.gov/#1612
type: UnificationXref
db: Entrez Gene
id: 1612

http://www.ncbi.nlm.nih.gov/#6093
type: UnificationXref
db: Entrez Gene
id: 6093

.KLF6.PROMOTES.DAPK2.
type: TemplateReactionRegulation
xref: 18521079
data source: Spike
control type: ACTIVATION
controller: KLF6
controlled: Transcription.Regulation.P.KLF6.DAPK2

Integrin, alpha/beta1.complex_inactive
type: Protein

NEO1
type: Protein
entity reference: NEO1

.DAPK3.INHIBITS.PPP1R12A.
type: Catalysis
data source: Spike
xref: 11226254
controller: DAPK3
control type: INHIBITION
controlled: Phosphorylation.I.DAPK3.PPP1R12A

HSP90AA1
type: Protein
entity reference: HSP90AA1

10629061
type: PublicationXref
title: Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis
db: PubMed
id: 10629061

.UNC5B.PROMOTES.DAPK1.
type: Catalysis
data source: Spike
xref: 15729359
controller: UNC5B
control type: ACTIVATION
controlled: Physical.Interaction.P.UNC5B.DAPK1

TP53
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7157

E2F1
type: Protein
entity reference: E2F1

18521079
type: PublicationXref
title: DAPK2 is a novel E2F1/KLF6 target gene involved in their proapoptotic function
db: PubMed
id: 18521079

16213824
type: PublicationXref
title: The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling
db: PubMed
id: 16213824

RPS6_inactive
type: Protein
entity reference: RPS6

15001356
type: PublicationXref
title: Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1
db: PubMed
id: 15001356

ERK.family
type: Protein
data source: Spike
xref: TAU:F.000011

Translation
type: MolecularInteraction
participant: DAPK2_inactive
participant: DAPK2_RNA

.BCL2L1.INHIBITS.BECN1.
type: Catalysis
data source: Spike
xref: 17337444
xref: 9765397
controller: BCL2L1
control type: INHIBITION
controlled: Physical.Interaction.I.BCL2L1.BECN1

15096528
type: PublicationXref
title: ZIP kinase is responsible for the phosphorylation of myosin II and necessary for cell motility in mammalian fibroblasts
db: PubMed
id: 15096528

AR
type: Protein
entity reference: AR

MIB1
type: Protein
entity reference: MIB1

18084323
type: PublicationXref
title: ZIP kinase plays a crucial role in androgen receptor-mediated transcription
db: PubMed
id: 18084323

http://www.ncbi.nlm.nih.gov/#4172
type: UnificationXref
db: Entrez Gene
id: 4172

17158456
type: PublicationXref
title: ROCK1 phosphorylates and activates zipper-interacting protein kinase
db: PubMed
id: 17158456

PPP1R14A
type: Protein
entity reference: PPP1R14A

MIB1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#57534

http://www.ncbi.nlm.nih.gov/#596
type: UnificationXref
db: Entrez Gene
id: 596

.DAPK3.PROMOTES.Family.RLC.(muscle)...(MYL5).
type: Catalysis
data source: Spike
xref: 11384979
controller: DAPK3
control type: ACTIVATION
controlled: Phosphorylation.P.DAPK3.RLC.(muscle)

9765397
type: PublicationXref
title: Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein
db: PubMed
id: 9765397

http://www.ncbi.nlm.nih.gov/#598
type: UnificationXref
db: Entrez Gene
id: 598

Spike
type: Provenance

.ROCK1.PROMOTES.DAPK3.
type: Catalysis
data source: Spike
xref: 17158456
controller: ROCK1
control type: ACTIVATION
controlled: Phosphorylation.P.ROCK1.DAPK3

.DAPK3.PROMOTES.Family.RLC.(nonmuscle)...(MYL12A).
type: Catalysis
data source: Spike
xref: 15096528
xref: 10356987
xref: 11781833
controller: DAPK3
control type: ACTIVATION
controlled: Phosphorylation.P.DAPK3.RLC.(nonmuscle)

BCL2
type: Protein
entity reference: BCL2

http://www.ncbi.nlm.nih.gov/#23521
type: UnificationXref
db: Entrez Gene
id: 23521

.SMAD2.PROMOTES.DAPK1.
type: TemplateReactionRegulation
xref: 11740493
data source: Spike
control type: ACTIVATION
controller: SMAD2
controlled: Transcription.Regulation.P.SMAD2.DAPK1

15611134
type: PublicationXref
title: Regulation of zipper-interacting protein kinase activity in vitro and in vivo by multisite phosphorylation
db: PubMed
id: 15611134

.DAPK3.PROMOTES.AR.
type: Catalysis
data source: Spike
xref: 18084323
controller: DAPK3
control type: ACTIVATION
controlled: Physical.Interaction.P.DAPK3.AR

http://www.ncbi.nlm.nih.gov/#23604
type: UnificationXref
db: Entrez Gene
id: 23604

RLC (nonmuscle).family
type: Protein
data source: Spike
xref: WSC:F.000019

.Complex.Ca/CaM....PROMOTES.DAPK2.
type: Catalysis
data source: Spike
xref: 10629061
controller: Calcium-Calmodulin complex
control type: ACTIVATION
controlled: Physical.Interaction.P.Ca/CaM.DAPK2

.TP53.PROMOTES.DAPK1.
type: TemplateReactionRegulation
xref: 15608685
data source: Spike
control type: ACTIVATION
controller: TP53
controlled: Transcription.Regulation.P.TP53.DAPK1

19180116
type: PublicationXref
title: DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy
db: PubMed
id: 19180116

11226254
type: PublicationXref
title: Identification of the endogenous smooth muscle myosin phosphatase-associated kinase
db: PubMed
id: 11226254

SMAD2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4087

NR3C1_inactive
type: Protein
entity reference: NR3C1

.Complex.GAIT.complex..RPL13A..INHIBITS.DAPK3.
type: Catalysis
data source: Spike
xref: 18995835
controller: interferon (IFN)-gamma-activated inhibitor of translation
control type: INHIBITION
controlled: Translational.Regulation.I.GAIT.complex.DAPK3

PhysicalInteraction [TLN1 -- Complex f-actin {} ]
type: MolecularInteraction
xref: 8937989
comment: connects focal adhesions/cell membrane to actin network
participant: TLN1
participant: filamentous actin

RPL13A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#23521

myosin phosphatase.complex_inactive
type: Protein

DAPK1_RNA
type: RnaRegion
entity reference: DAPK1

16915296
type: PublicationXref
title: Divorcing ARF and p53: an unsettled case
db: PubMed
id: 16915296

TSC2
type: Protein
entity reference: TSC2

18995835
type: PublicationXref
title: DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression
db: PubMed
id: 18995835

PTPRF
type: Protein
entity reference: PTPRF

17087515
type: PublicationXref
title: Death-associated protein kinase phosphorylates mammalian ribosomal protein S6 and reduces protein synthesis
db: PubMed
id: 17087515

.DAPK1.PROMOTES.Family.RLC.(nonmuscle)...(MYL12A).
type: Catalysis
data source: Spike
xref: 11485996
xref: 15002035
xref: 14600263
controller: DAPK1
control type: ACTIVATION
controlled: Phosphorylation.P.DAPK1.RLC.(nonmuscle)

MDM2
type: Protein
entity reference: MDM2

http://www.ncbi.nlm.nih.gov/#4193
type: UnificationXref
db: Entrez Gene
id: 4193

ERK.family_inactive
type: Protein

.Complex.Ca/CaM....PROMOTES.DAPK1.
type: Catalysis
data source: Spike
xref: 9118961
controller: Calcium-Calmodulin complex
control type: ACTIVATION
controlled: Physical.Interaction.P.Ca/CaM.DAPK1

MTOR_inactive
type: Protein
entity reference: MTOR

.DAPK1.PROMOTES.CDKN2A.
type: Catalysis
data source: Spike
xref: 11146619
controller: DAPK1
control type: ACTIVATION
controlled: Indirect.P.DAPK1.CDKN2A

.BCL2.INHIBITS.BECN1.
type: Catalysis
data source: Spike
xref: 16179260
xref: 9765397
controller: BCL2
control type: INHIBITION
controlled: Physical.Interaction.I.BCL2.BECN1

http://www.ncbi.nlm.nih.gov/#4659
type: UnificationXref
db: Entrez Gene
id: 4659

http://www.ncbi.nlm.nih.gov/#7249
type: UnificationXref
db: Entrez Gene
id: 7249

PTPRF
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5792

http://www.ncbi.nlm.nih.gov/#4088
type: UnificationXref
db: Entrez Gene
id: 4088

http://www.ncbi.nlm.nih.gov/#4087
type: UnificationXref
db: Entrez Gene
id: 4087

12730201
type: PublicationXref
title: Ca2+-dependent phosphorylation of syntaxin-1A by the death-associated protein (DAP) kinase regulates its interaction with Munc18
db: PubMed
id: 12730201

http://www.ncbi.nlm.nih.gov/#4089
type: UnificationXref
db: Entrez Gene
id: 4089

.SMAD3.PROMOTES.DAPK1.
type: TemplateReactionRegulation
xref: 11740493
data source: Spike
control type: ACTIVATION
controller: SMAD3
controlled: Transcription.Regulation.P.SMAD3.DAPK1

MAP1LC3B
type: Protein
entity reference: MAP1LC3B

9465032
type: PublicationXref
title: RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
db: PubMed
id: 9465032

18535204
type: PublicationXref
title: Attenuation of EPO-dependent erythroblast formation by death-associated protein kinase-2
db: PubMed
id: 18535204

KLF6
type: Protein
entity reference: KLF6

http://www.ncbi.nlm.nih.gov/#2908
type: UnificationXref
db: Entrez Gene
id: 2908

Protein phosphatase 2A
type: Complex
data source: Spike
display name: PP2A.complex

.SMAD4.PROMOTES.DAPK1.
type: Catalysis
data source: Spike
xref: 11740493
controller: SMAD4
control type: ACTIVATION
controlled: Translational.Regulation.P.SMAD4.DAPK1

143236
type: PublicationXref
title: Nonmuscle contractile proteins: the role of actin and myosin in cell motility and shape determination
db: PubMed
id: 143236

.DAPK1.INHIBITS.Family.ERK...(MAPK6).
type: Catalysis
data source: Spike
xref: 15616583
controller: DAPK1
control type: INHIBITION
controlled: Physical.Interaction.I.DAPK1.ERK

.Complex.GAIT.complex..RPL13A..INHIBITS.DAPK1.
type: Catalysis
data source: Spike
xref: 18995835
controller: interferon (IFN)-gamma-activated inhibitor of translation
control type: INHIBITION
controlled: Translational.Regulation.I.GAIT.complex.DAPK1

DAPK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1612

http://www.ncbi.nlm.nih.gov/#81631
type: UnificationXref
db: Entrez Gene
id: 81631

.MTOR.PROMOTES.RPS6KB1.
type: Catalysis
data source: Spike
xref: 9465032
controller: MTOR
control type: ACTIVATION
controlled: Phosphorylation.P.MTOR.RPS6KB1

Calcium-Calmodulin complex
type: Complex
data source: Spike
display name: Ca/CaM.complex