Nuclear caspase-3 and caspase-7 activation, and poly(ADP-ribose) polymerase cleavage are early events in camptothecin-induced apoptosis
In vitro selection and characterization of Bcl-X(L)-binding proteins from a mix of tissue-specific mRNA display libraries
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1
The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32
A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
Dexamethasone protects auditory hair cells against TNFalpha-initiated apoptosis via activation of PI3K/Akt and NFkappaB signaling
TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex
Linkage of caspase-mediated degradation of paxillin to apoptosis in Ba/F3 murine pro-B lymphocytes
[W206R]-procaspase 3: an inactivatable substrate for caspase 8
Active caspase-1 is a regulator of unconventional protein secretion
The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation
Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner
Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL
Differential regulation of Bax and Bak by anti-apoptotic Bcl-2 family proteins Bcl-B and Mcl-1
Dismantling cell-cell contacts during apoptosis is coupled to a caspase-dependent proteolytic cleavage of beta-catenin
DISC (Primary complex) FADD, CASP8, CASP10
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
A single BIR domain of XIAP sufficient for inhibiting caspases
Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production
The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c
PhysicalInteraction [RIPK1 -- TNFRSF1A ]
Study of DFF45 in its role of chaperone and inhibitor: two independent inhibitory domains of DFF40 nuclease activity
Identification of caspase 3-mediated cleavage and functional alteration of eukaryotic initiation factor 2alpha in apoptosis
Overview of cell death signaling pathways
Degradation of focal adhesion proteins paxillin and p130cas by caspases or calpains in apoptotic rat-1 and L929 cells
Gelsolin superfamily proteins: key regulators of cellular functions
The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation
Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway
Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment
Alternative splicing and caspase-mediated cleavage generate antagonistic variants of the stress oncoprotein LEDGF/p75
Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis
Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members
Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria
BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly
Caspase proteolysis of the integrin beta4 subunit disrupts hemidesmosome assembly, promotes apoptosis, and inhibits cell migration
Disruption of focal adhesions mediates detachment during neuronal apoptosis
Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis
An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7
Structure of the heterodimeric complex between CAD domains of CAD and ICAD
X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes
Caspase-3-induced gelsolin fragmentation contributes to actin cytoskeletal collapse, nucleolysis, and apoptosis of vascular smooth muscle cells exposed to proinflammatory cytokines
Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation
Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
Characterization of Fas (Apo-1, CD95)-Fas ligand interaction
NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes
BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members
X-linked IAP is a direct inhibitor of cell-death proteases
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
Suppression of lipopolysaccharide-induced nuclear factor-kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages
Apoptotic cleavage of NuMA at the C-terminal end is related to nuclear disruption and death amplification
IAP family proteins--suppressors of apoptosis
Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin
Nonionic detergents induce dimerization among members of the Bcl-2 family
The role of c-FLIP in modulation of CD95-induced apoptosis
IAP proteins: blocking the road to death's door
Caspase-10 is an initiator caspase in death receptor signaling
CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis
Bcl-XL protects BimEL-induced Bax conformational change and cytochrome C release independent of interacting with Bax or BimEL
Caspase-mediated cleavage of focal adhesion kinase pp125FAK and disassembly of focal adhesions in human endothelial cell apoptosis
Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis
Pro-caspase-3 is a major physiologic target of caspase-8
Unique and overlapping substrate specificities of caspase-8 and caspase-10
Inhibition of death receptor signals by cellular FLIP
The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock
A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members
Disruption of the interaction of mammalian protein synthesis eukaryotic initiation factor 4B with the poly(A)-binding protein by caspase- and viral protease-mediated cleavages
The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress
Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
TNF-alpha induces two distinct caspase-8 activation pathways
Mutagenesis of the BH3 domain of BAX identifies residues critical for dimerization and killing
Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death
Regulation of cell death protease caspase-9 by phosphorylation
Delineation of the caspase-9 signaling cascade
CD95 (Fas)-induced caspase-mediated proteolysis of NF-kappaB
Apoptosis and caspases regulate death and inflammation in sepsis
Dephosphorylation of focal adhesion kinase (FAK) and loss of focal contacts precede caspase-mediated cleavage of FAK during apoptosis in renal epithelial cells
The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA
The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
Activation of death-inducing signaling complex (DISC) by pro-apoptotic C-terminal fragment of RIP
Changes in integrity and association of eukaryotic protein synthesis initiation factors during apoptosis
Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death
TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer
Phospholipase C-gamma 2 couples Bruton's tyrosine kinase to the NF-kappaB signaling pathway in B lymphocytes
Activation of the NF-kappaB pathway by caspase 8 and its homologs
Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family
NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain
IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
The membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9
CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP
Phosphatidylserine externalization during CD95-induced apoptosis of cells and cytoplasts requires ICE/CED-3 protease activity
Caspase-mediated cleavage of the stacking protein GRASP65 is required for Golgi fragmentation during apoptosis
c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment
Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)
Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation
Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing
Activation of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease). Oligomerization and direct interaction with histone H1
TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
Molecular cloning and expression of a receptor for human tumor necrosis factor
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
Eukaryotic translation initiation factor 4G is targeted for proteolytic cleavage by caspase 3 during inhibition of translation in apoptotic cells
Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis
Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis
Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis
Exploiting the PI3K/AKT pathway for cancer drug discovery
Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase
IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
CPP32/Yama/apopain cleaves the catalytic component of DNA-dependent protein kinase in the holoenzyme
A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation
The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet
Oxidative stress induces nuclear loss of DNA repair proteins Ku70 and Ku80 and apoptosis in pancreatic acinar AR42J cells
Identification of amino acid residues important for ligand binding to Fas
Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis
DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
Conversion of Bcl-2 to a Bax-like death effector by caspases
Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes
Nonmuscle contractile proteins: the role of actin and myosin in cell motility and shape determination
Apaf1 in developmental apoptosis and cancer: how many ways to die?
The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites