16374543
type: PublicationXref
db: PubMed
id: 16374543
title: Nuclear caspase-3 and caspase-7 activation, and poly(ADP-ribose) polymerase cleavage are early events in camptothecin-induced apoptosis

APAF1
type: Protein
entity reference: APAF1

11283018
type: PublicationXref
db: PubMed
id: 11283018
title: In vitro selection and characterization of Bcl-X(L)-binding proteins from a mix of tissue-specific mRNA display libraries

BAK1_inactive
type: Protein
entity reference: BAK1

.BIRC5.INHIBITS.CASP7.
type: Catalysis
controller: BIRC5
controlled: Physical.Interaction.I.BIRC5.CASP7
control type: INHIBITION
xref: 11170436
data source: Spike

7538907
type: PublicationXref
db: PubMed
id: 7538907
title: FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

FGF2_inactive
type: Protein
entity reference: FGF2

12242151
type: PublicationXref
db: PubMed
id: 12242151
title: Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

.BCL2.INHIBITS.BAX.
type: Catalysis
controller: BCL2
controlled: Other.I.BCL2.BAX
control type: INHIBITION
xref: 8358790
xref: 9463381
xref: 9111042
data source: Spike

.CASP3.INHIBITS.SPTAN1.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.SPTAN1
control type: INHIBITION
xref: 8910516
xref: 9624143
data source: Spike

BCL2L2_inactive
type: Protein
entity reference: BCL2L2

PARP1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#142
organism: Homo sapiens

BCL2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#596
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#2021
type: UnificationXref
db: Entrez Gene
id: 2021

.CASP8.PROMOTES.BID.
type: Catalysis
controller: CASP8
controlled: Proteolytic.Processing.P.CASP8.BID
control type: ACTIVATION
xref: 9727491
xref: 9727492
data source: Spike

http://www.ncbi.nlm.nih.gov/#2023
type: UnificationXref
db: Entrez Gene
id: 2023

http://www.ncbi.nlm.nih.gov/#1975
type: UnificationXref
db: Entrez Gene
id: 1975

filamentous actin
type: Complex
data source: Spike
display name: f-actin.complex

PSIP1_inactive
type: Protein
entity reference: PSIP1

.NLRP1.PROMOTES.Complex.apoptosome..CYCS,.CASP9,.APAF1.(CYCS).
type: Catalysis
controller: NLRP1
controlled: Physical.Interaction.P.NLRP1.apoptosome
control type: ACTIVATION
xref: 11706994
data source: Spike

17418785
type: PublicationXref
db: PubMed
id: 17418785
title: Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1

8900201
type: PublicationXref
db: PubMed
id: 8900201
title: The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32

http://www.ncbi.nlm.nih.gov/#1978
type: UnificationXref
db: Entrez Gene
id: 1978

.CASP1.PROMOTES.FGF2.
type: Catalysis
controller: CASP1
controlled: Physical.Interaction.P.CASP1.FGF2
control type: ACTIVATION
xref: 18329368
data source: Spike

.CASP3.INHIBITS.GORASP1.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.GORASP1
control type: INHIBITION
xref: 11815631
data source: Spike

.BIRC2.INHIBITS.CASP9.
type: Catalysis
controller: BIRC2
controlled: Physical.Interaction.I.BIRC2.CASP9
control type: INHIBITION
xref: 9545235
xref: 9990849
data source: Spike

7536190
type: PublicationXref
db: PubMed
id: 7536190
title: A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain

AIFM1
type: Protein
entity reference: AIFM1

EIF4G1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1981
organism: Homo sapiens

AKT1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#207
organism: Homo sapiens

RIPK1
type: Protein
entity reference: RIPK1

focal adhesion complex
type: Complex
component: PXN
component: BCAR1
component: PTK2
data source: Spike
display name: focal adhesion.complex

ALDOA
type: Protein
entity reference: ALDOA

.TRADD.PROMOTES.RIPK1.
type: Catalysis
controller: TRADD
controlled: Physical.Interaction.P.TRADD.RIPK1
control type: ACTIVATION
xref: 8612133
data source: Spike

http://www.ncbi.nlm.nih.gov/#1982
type: UnificationXref
db: Entrez Gene
id: 1982

CASP8_inactive
type: Protein
entity reference: CASP8

http://www.ncbi.nlm.nih.gov/#1981
type: UnificationXref
db: Entrez Gene
id: 1981

PhysicalInteraction [CARD18 -- CARD8 ]
type: MolecularInteraction
participant: CARD18
participant: CARD8
xref: 11821383

15694340
type: PublicationXref
db: PubMed
id: 15694340
title: Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

.BAD.INHIBITS.BCL2.
type: Catalysis
controller: BAD
controlled: Physical.Interaction.I.BAD.BCL2
control type: INHIBITION
xref: 11583631
xref: 11483855
xref: 9463381
xref: 7834748
data source: Spike

.FADD.PROMOTES.CASP8.
type: Catalysis
controller: FADD
controlled: Physical.Interaction.P.FADD.CASP8
control type: ACTIVATION
xref: 8681376
data source: Spike

http://www.ncbi.nlm.nih.gov/#3606
type: UnificationXref
db: Entrez Gene
id: 3606

GSN
type: Protein
entity reference: GSN

http://www.ncbi.nlm.nih.gov/#9131
type: UnificationXref
db: Entrez Gene
id: 9131

CASP6
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#839
organism: Homo sapiens

.BIRC5.INHIBITS.CASP9.
type: Catalysis
controller: BIRC5
controlled: Physical.Interaction.I.BIRC5.CASP9
control type: INHIBITION
xref: 11069302
data source: Spike

http://www.ncbi.nlm.nih.gov/#8672
type: UnificationXref
db: Entrez Gene
id: 8672

IL1F7
type: Protein
entity reference: IL1F7

EIF4G3
type: Protein
entity reference: EIF4G3

19442713
type: PublicationXref
db: PubMed
id: 19442713
title: Dexamethasone protects auditory hair cells against TNFalpha-initiated apoptosis via activation of PI3K/Akt and NFkappaB signaling

IL1A
type: Protein
entity reference: IL1A

CASP6
type: Protein
entity reference: CASP6

CTNNB1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1499
organism: Homo sapiens

NUMA1_inactive
type: Protein
entity reference: NUMA1

CASP7
type: Protein
entity reference: CASP7

.BCL2.INHIBITS.BAK1.
type: Catalysis
controller: BCL2
controlled: Physical.Interaction.I.BCL2.BAK1
control type: INHIBITION
xref: 9463381
data source: Spike

.BIRC2.INHIBITS.CASP7.
type: Catalysis
controller: BIRC2
controlled: Physical.Interaction.I.BIRC2.CASP7
control type: INHIBITION
xref: 9384571
data source: Spike

PXN
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5829
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#2934
type: UnificationXref
db: Entrez Gene
id: 2934

http://www.ncbi.nlm.nih.gov/#8669
type: UnificationXref
db: Entrez Gene
id: 8669

BCL2L1
type: Protein
entity reference: BCL2L1

RLC (nonmuscle).family_inactive
type: Protein

http://www.ncbi.nlm.nih.gov/#22900
type: UnificationXref
db: Entrez Gene
id: 22900

.CASP1.PROMOTES.IL1F7.
type: Catalysis
controller: CASP1
controlled: Proteolytic.Processing.P.CASP1.IL1F7
control type: ACTIVATION
xref: 12096920
data source: Spike

ITGB4
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3691
organism: Homo sapiens

.CASP3.INHIBITS.Complex.NFkB...(RELA).
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.NFkB
control type: INHIBITION
xref: 9500443
data source: Spike

PhysicalInteraction [NLRP3 -- PYCARD ]
type: MolecularInteraction
participant: PYCARD
participant: NLRP3
xref: 11250163

8612133
type: PublicationXref
db: PubMed
id: 8612133
title: TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

.CASP3.PROMOTES.ACIN1.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.P.CASP3.ACIN1
control type: ACTIVATION
xref: 10490026
data source: Spike

DFFA
type: Protein
entity reference: DFFA

http://www.ncbi.nlm.nih.gov/#1499
type: UnificationXref
db: Entrez Gene
id: 1499

CTNNB1
type: Protein
entity reference: CTNNB1

.CASP3.INHIBITS.PXN.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.PXN
control type: INHIBITION
xref: 11825902
xref: 11511102
xref: 11447317
data source: Spike

11825902
type: PublicationXref
db: PubMed
id: 11825902
title: Linkage of caspase-mediated degradation of paxillin to apoptosis in Ba/F3 murine pro-B lymphocytes

.Complex.f.actin....PROMOTES.Complex.myosin.II..Family.RLC.(nonmuscle)....(MYH9).
type: Catalysis
controller: filamentous actin
controlled: Other.P.f.actin.myosin.II
control type: ACTIVATION
xref: 143236
data source: Spike

.CASP3.INHIBITS.XIAP.
type: Catalysis
controller: CASP3
controlled: Protein.Degradation.I.CASP3.XIAP
control type: INHIBITION
xref: 15725726
data source: Spike

.CASP3.INHIBITS.VIM.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.VIM
control type: INHIBITION
xref: 11423904
data source: Spike

11437602
type: PublicationXref
db: PubMed
id: 11437602
title: [W206R]-procaspase 3: an inactivatable substrate for caspase 8

Caspases, effector.family
type: Protein
member physical entity: CASP3
member physical entity: CASP6
member physical entity: CASP7
xref: WSC:F.000006
data source: Spike

FAS_inactive
type: Protein
entity reference: FAS

CASP9_inactive
type: Protein
entity reference: CASP9

http://www.ncbi.nlm.nih.gov/#7431
type: UnificationXref
db: Entrez Gene
id: 7431

AIFM1_inactive
type: Protein
entity reference: AIFM1

BAD
type: Protein
entity reference: BAD

18329368
type: PublicationXref
db: PubMed
id: 18329368
title: Active caspase-1 is a regulator of unconventional protein secretion

SPTAN1
type: Protein
entity reference: SPTAN1

EIF4G2_inactive
type: Protein
entity reference: EIF4G2

11250163
type: PublicationXref
db: PubMed
id: 11250163
title: The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation

IL33
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#90865
organism: Homo sapiens

BID
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#637
organism: Homo sapiens

.BIRC5.INHIBITS.CASP3.
type: Catalysis
controller: BIRC5
controlled: Physical.Interaction.I.BIRC5.CASP3
control type: INHIBITION
xref: 9850056
data source: Spike

.CASP1.PROMOTES.SREBF2.
type: Catalysis
controller: CASP1
controlled: Indirect.P.CASP1.SREBF2
control type: ACTIVATION
xref: 16990137
data source: Spike

http://www.ncbi.nlm.nih.gov/#57448
type: UnificationXref
db: Entrez Gene
id: 57448

GSN_inactive
type: Protein
entity reference: GSN

9922454
type: PublicationXref
db: PubMed
id: 9922454
title: Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

GOLGA3_inactive
type: Protein
entity reference: GOLGA3

BAX
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#581
organism: Homo sapiens

CARD8
type: Protein
entity reference: CARD8

http://www.ncbi.nlm.nih.gov/#7167
type: UnificationXref
db: Entrez Gene
id: 7167

.CASP2.INHIBITS.GOLGA3.
type: Catalysis
controller: CASP2
controlled: Proteolytic.Processing.I.CASP2.GOLGA3
control type: INHIBITION
xref: 10791974
data source: Spike

11175750
type: PublicationXref
db: PubMed
id: 11175750
title: Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

CASP5
type: Protein
entity reference: CASP5

BAK1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#578
organism: Homo sapiens

CASP8
type: Protein
entity reference: CASP8

http://www.ncbi.nlm.nih.gov/#59082
type: UnificationXref
db: Entrez Gene
id: 59082

Inflammasome.complex
type: Complex
component: PYCARD
component: CASP5
component: CASP1
component: NLRP1
data source: Spike

EIF2A_inactive
type: Protein
entity reference: EIF2A

EIF3J
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8669
organism: Homo sapiens

VIM
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7431
organism: Homo sapiens

.CASP3.PROMOTES.ROCK1.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.P.CASP3.ROCK1
control type: ACTIVATION
xref: 11283607
data source: Spike

BCL2L1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#598
organism: Homo sapiens

18178565
type: PublicationXref
db: PubMed
id: 18178565
title: Differential regulation of Bax and Bak by anti-apoptotic Bcl-2 family proteins Bcl-B and Mcl-1

9348292
type: PublicationXref
db: PubMed
id: 9348292
title: Dismantling cell-cell contacts during apoptosis is coupled to a caspase-dependent proteolytic cleavage of beta-catenin

DISC (Primary complex) FADD, CASP8, CASP10
type: Complex
component: FAS
component: TNFRSF1A
component: RIPK1
component: CFLAR
component: TRADD
data source: Spike
display name: DISC.complex

.CASP3.PROMOTES.GSN.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.P.CASP3.GSN
control type: ACTIVATION
xref: 9323209
xref: 9930654
data source: Spike

IL18
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3606
organism: Homo sapiens

PSIP1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#11168
organism: Homo sapiens

PIDDosome.complex
type: Complex
component: LRDD
component: CASP2
component: CRADD
data source: Spike

VIM
type: Protein
entity reference: VIM

.BIRC2.INHIBITS.CASP3.
type: Catalysis
controller: BIRC2
controlled: Physical.Interaction.I.BIRC2.CASP3
control type: INHIBITION
xref: 9384571
xref: 9990849
xref: 12042762
data source: Spike

11326099
type: PublicationXref
db: PubMed
id: 11326099
title: Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

http://www.ncbi.nlm.nih.gov/#9564
type: UnificationXref
db: Entrez Gene
id: 9564

16286016
type: PublicationXref
db: PubMed
id: 16286016
title: IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines

.CRADD.PROMOTES.CASP2.
type: Catalysis
controller: CRADD
controlled: Physical.Interaction.P.CRADD.CASP2
control type: ACTIVATION
xref: 8985253
xref: 9695946
data source: Spike

.CASP1.PROMOTES.IL18.
type: Catalysis
controller: CASP1
controlled: Other.P.CASP1.IL18
control type: ACTIVATION
xref: 17039247
data source: Spike

EIF4G2
type: Protein
entity reference: EIF4G2

http://www.ncbi.nlm.nih.gov/#4000
type: UnificationXref
db: Entrez Gene
id: 4000

EIF4B
type: Protein
entity reference: EIF4B

EIF4B_inactive
type: Protein
entity reference: EIF4B

IL18_inactive
type: Protein
entity reference: IL18

CASP1
type: Protein
entity reference: CASP1

DFFB
type: Protein
entity reference: DFFB

Homo sapiens
type: BioSource
xref: 9606

.BCL2L2.INHIBITS.BAX.
type: Catalysis
controller: BCL2L2
controlled: Physical.Interaction.I.BCL2L2.BAX
control type: INHIBITION
xref: 18178565
data source: Spike

.CASP3.INHIBITS.PARP1.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.PARP1
control type: INHIBITION
xref: 7774019
data source: Spike

BCL2_inactive
type: Protein
entity reference: BCL2

BCL2L2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#599
organism: Homo sapiens

DFFB
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1677
organism: Homo sapiens

.ROCK1.PROMOTES.Family.RLC.(nonmuscle)...(MYL12A).
type: Catalysis
controller: ROCK1
controlled: Phosphorylation.P.ROCK1.RLC.(nonmuscle)
control type: ACTIVATION
xref: 11283607
xref: 8702756
data source: Spike

9525868
type: PublicationXref
db: PubMed
id: 9525868
title: A single BIR domain of XIAP sufficient for inhibiting caspases

http://www.ncbi.nlm.nih.gov/#90865
type: UnificationXref
db: Entrez Gene
id: 90865

12096920
type: PublicationXref
db: PubMed
id: 12096920
title: Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production

9463381
type: PublicationXref
db: PubMed
id: 9463381
title: The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4

BIRC5
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#332
organism: Homo sapiens

CASP7_inactive
type: Protein
entity reference: CASP7

EIF2A
type: Protein
entity reference: EIF2A

http://www.ncbi.nlm.nih.gov/#355
type: UnificationXref
db: Entrez Gene
id: 355

DFFA_inactive
type: Protein
entity reference: DFFA

http://www.ncbi.nlm.nih.gov/#356
type: UnificationXref
db: Entrez Gene
id: 356

10950869
type: PublicationXref
db: PubMed
id: 10950869
title: tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

TAU:F.000012
type: UnificationXref
db: Spike DB
id: TAU:F-000012

BIRC2_inactive
type: Protein
entity reference: BIRC2

PhysicalInteraction [RIPK1 -- TNFRSF1A ]
type: MolecularInteraction
participant: TNFRSF1A
participant: RIPK1
xref: 18329793

ACIN1_inactive
type: Protein
entity reference: ACIN1

10527860
type: PublicationXref
db: PubMed
id: 10527860
title: Study of DFF45 in its role of chaperone and inhibitor: two independent inhibitory domains of DFF40 nuclease activity

CASP8
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#841
organism: Homo sapiens

EIF4EBP1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1978
organism: Homo sapiens

10734073
type: PublicationXref
db: PubMed
id: 10734073
title: Identification of caspase 3-mediated cleavage and functional alteration of eukaryotic initiation factor 2alpha in apoptosis

http://www.ncbi.nlm.nih.gov/#207
type: UnificationXref
db: Entrez Gene
id: 207

TAU:F.000018
type: UnificationXref
db: Spike DB
id: TAU:F-000018

CASP10_inactive
type: Protein
entity reference: CASP10

.CFLAR.INHIBITS.FADD.
type: Catalysis
controller: CFLAR
controlled: Physical.Interaction.I.CFLAR.FADD
control type: INHIBITION
xref: 9217161
data source: Spike

CYCS
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#54205
organism: Homo sapiens

.BID.PROMOTES.BAK1.
type: Catalysis
controller: BID
controlled: Physical.Interaction.P.BID.BAK1
control type: ACTIVATION
xref: 10950869
data source: Spike

.BIRC3.INHIBITS.CASP9.
type: Catalysis
controller: BIRC3
controlled: Physical.Interaction.I.BIRC3.CASP9
control type: INHIBITION
xref: 9545235
xref: 9990849
data source: Spike

.FADD.PROMOTES.CASP10.
type: Catalysis
controller: FADD
controlled: Physical.Interaction.P.FADD.CASP10
control type: ACTIVATION
xref: 11717445
data source: Spike

CFLAR
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8837
organism: Homo sapiens

EIF4G1_inactive
type: Protein
entity reference: EIF4G1

CRADD
type: Protein
entity reference: CRADD

15725726
type: PublicationXref
db: PubMed
id: 15725726
title: Overview of cell death signaling pathways

http://www.ncbi.nlm.nih.gov/#226
type: UnificationXref
db: Entrez Gene
id: 226

11511102
type: PublicationXref
db: PubMed
id: 11511102
title: Degradation of focal adhesion proteins paxillin and p130cas by caspases or calpains in apoptotic rat-1 and L929 cells

http://www.ncbi.nlm.nih.gov/#5591
type: UnificationXref
db: Entrez Gene
id: 5591

http://www.ncbi.nlm.nih.gov/#4926
type: UnificationXref
db: Entrez Gene
id: 4926

15526166
type: PublicationXref
db: PubMed
id: 15526166
title: Gelsolin superfamily proteins: key regulators of cellular functions

8985253
type: PublicationXref
db: PubMed
id: 8985253
title: RAIDD is a new 'death' adaptor molecule

7758105
type: PublicationXref
db: PubMed
id: 7758105
title: The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

IKK complex
type: Complex
data source: Spike
display name: IKK.complex

CASP2
type: Protein
entity reference: CASP2

.NLRP1.PROMOTES.CASP5.
type: Catalysis
controller: NLRP1
controlled: Physical.Interaction.P.NLRP1.CASP5
control type: ACTIVATION
xref: 12191486
data source: Spike

PYCARD
type: Protein
entity reference: PYCARD

.CASP3.INHIBITS.EIF2A.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.EIF2A
control type: INHIBITION
xref: 10734073
data source: Spike

12842894
type: PublicationXref
db: PubMed
id: 12842894
title: Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway

FAS
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#355
organism: Homo sapiens

PTK2
type: Protein
entity reference: PTK2

FASLG
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#356
organism: Homo sapiens

NLRP1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#22861
organism: Homo sapiens

XIAP
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#331
organism: Homo sapiens

.CASP1.PROMOTES.CASP7.
type: Catalysis
controller: CASP1
controlled: Proteolytic.Processing.P.CASP1.CASP7
control type: ACTIVATION
xref: 18667412
data source: Spike

CRADD
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8738
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#3553
type: UnificationXref
db: Entrez Gene
id: 3553

http://www.ncbi.nlm.nih.gov/#3691
type: UnificationXref
db: Entrez Gene
id: 3691

http://www.ncbi.nlm.nih.gov/#3552
type: UnificationXref
db: Entrez Gene
id: 3552

http://www.ncbi.nlm.nih.gov/#330
type: UnificationXref
db: Entrez Gene
id: 330

CRADD_inactive
type: Protein
entity reference: CRADD

http://www.ncbi.nlm.nih.gov/#331
type: UnificationXref
db: Entrez Gene
id: 331

http://www.ncbi.nlm.nih.gov/#841
type: UnificationXref
db: Entrez Gene
id: 841

http://www.ncbi.nlm.nih.gov/#842
type: UnificationXref
db: Entrez Gene
id: 842

http://www.ncbi.nlm.nih.gov/#332
type: UnificationXref
db: Entrez Gene
id: 332

http://www.ncbi.nlm.nih.gov/#843
type: UnificationXref
db: Entrez Gene
id: 843

CYCS
type: Protein
entity reference: CYCS

http://www.ncbi.nlm.nih.gov/#637
type: UnificationXref
db: Entrez Gene
id: 637

http://www.ncbi.nlm.nih.gov/#840
type: UnificationXref
db: Entrez Gene
id: 840

.CASP1.INHIBITS.ENO1.
type: Catalysis
controller: CASP1
controlled: Proteolytic.Processing.I.CASP1.ENO1
control type: INHIBITION
xref: 17959595
data source: Spike

http://www.ncbi.nlm.nih.gov/#839
type: UnificationXref
db: Entrez Gene
id: 839

IL1A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3552
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#329
type: UnificationXref
db: Entrez Gene
id: 329

http://www.ncbi.nlm.nih.gov/#838
type: UnificationXref
db: Entrez Gene
id: 838

CASP2_inactive
type: Protein
entity reference: CASP2

http://www.ncbi.nlm.nih.gov/#835
type: UnificationXref
db: Entrez Gene
id: 835

http://www.ncbi.nlm.nih.gov/#834
type: UnificationXref
db: Entrez Gene
id: 834

.CASP1.PROMOTES.IL33.
type: Catalysis
controller: CASP1
controlled: Proteolytic.Processing.P.CASP1.IL33
control type: ACTIVATION
xref: 16286016
data source: Spike

PXN
type: Protein
entity reference: PXN

FGF2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2247
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#836
type: UnificationXref
db: Entrez Gene
id: 836

EIF4G3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8672
organism: Homo sapiens

PYCARD
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#29108
organism: Homo sapiens

CASP9
type: Protein
entity reference: CASP9

.CASP3.INHIBITS.EIF4EBP1.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.EIF4EBP1
control type: INHIBITION
xref: 10672017
data source: Spike

IL1B
type: Protein
entity reference: IL1B

9695946
type: PublicationXref
db: PubMed
id: 9695946
title: Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment

IL1B_inactive
type: Protein
entity reference: IL1B

.BIRC3.INHIBITS.CASP7.
type: Catalysis
controller: BIRC3
controlled: Physical.Interaction.I.BIRC3.CASP7
control type: INHIBITION
xref: 9384571
data source: Spike

http://www.ncbi.nlm.nih.gov/#29108
type: UnificationXref
db: Entrez Gene
id: 29108

.CASP9.PROMOTES.CASP3.
type: Catalysis
controller: CASP9
controlled: Proteolytic.Processing.P.CASP9.CASP3
control type: ACTIVATION
xref: 9390557
data source: Spike

18708362
type: PublicationXref
db: PubMed
id: 18708362
title: Alternative splicing and caspase-mediated cleavage generate antagonistic variants of the stress oncoprotein LEDGF/p75

BCL2L11
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#10018
organism: Homo sapiens

TPI1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7167
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#6093
type: UnificationXref
db: Entrez Gene
id: 6093

IL33
type: Protein
entity reference: IL33

PARP1_inactive
type: Protein
entity reference: PARP1

9323209
type: PublicationXref
db: PubMed
id: 9323209
title: Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis

10381646
type: PublicationXref
db: PubMed
id: 10381646
title: Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members

http://www.ncbi.nlm.nih.gov/#5829
type: UnificationXref
db: Entrez Gene
id: 5829

apoptosome.complex_inactive
type: Protein

ENO1
type: Protein
entity reference: ENO1

11832478
type: PublicationXref
db: PubMed
id: 11832478
title: Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria

FADD_inactive
type: Protein
entity reference: FADD

http://www.ncbi.nlm.nih.gov/#27178
type: UnificationXref
db: Entrez Gene
id: 27178

15721256
type: PublicationXref
db: PubMed
id: 15721256
title: BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

CARD16
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#114769
organism: Homo sapiens

CYCS_inactive
type: Protein
entity reference: CYCS

TPI1_inactive
type: Protein
entity reference: TPI1

TRADD_inactive
type: Protein
entity reference: TRADD

BIRC3
type: Protein
entity reference: BIRC3

.TNFRSF1A.PROMOTES.TRADD.
type: Catalysis
controller: TNFRSF1A
controlled: Physical.Interaction.P.TNFRSF1A.TRADD
control type: ACTIVATION
xref: 7758105
xref: 8565075
data source: Spike

http://www.ncbi.nlm.nih.gov/#599
type: UnificationXref
db: Entrez Gene
id: 599

17178732
type: PublicationXref
db: PubMed
id: 17178732
title: Caspase proteolysis of the integrin beta4 subunit disrupts hemidesmosome assembly, promotes apoptosis, and inhibits cell migration

http://www.ncbi.nlm.nih.gov/#596
type: UnificationXref
db: Entrez Gene
id: 596

http://www.ncbi.nlm.nih.gov/#598
type: UnificationXref
db: Entrez Gene
id: 598

AIFM1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#9131
organism: Homo sapiens

Spike
type: Provenance

LMNA
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4000
organism: Homo sapiens

ACIN1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#22985
organism: Homo sapiens

IL1F7
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#27178
organism: Homo sapiens

.CASP3.INHIBITS.ITGB4.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.ITGB4
control type: INHIBITION
xref: 17178732
data source: Spike

GOLGA3
type: Protein
entity reference: GOLGA3

11447317
type: PublicationXref
db: PubMed
id: 11447317
title: Disruption of focal adhesions mediates detachment during neuronal apoptosis

ROCK1_inactive
type: Protein
entity reference: ROCK1

9624143
type: PublicationXref
db: PubMed
id: 9624143
title: Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis

.CASP3.PROMOTES.PRKDC.
type: Catalysis
controller: CASP3
controlled: Protein.Degradation.P.CASP3.PRKDC
control type: ACTIVATION
xref: 8804412
xref: 12867423
data source: Spike

ACIN1
type: Protein
entity reference: ACIN1

ITGB4
type: Protein
entity reference: ITGB4

FADD
type: Protein
entity reference: FADD

VIM_inactive
type: Protein
entity reference: VIM

.CASP1.INHIBITS.ALDOA.
type: Catalysis
controller: CASP1
controlled: Proteolytic.Processing.I.CASP1.ALDOA
control type: INHIBITION
xref: 17959595
data source: Spike

BCL2L11
type: Protein
entity reference: BCL2L11

CASP10
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#843
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#1677
type: UnificationXref
db: Entrez Gene
id: 1677

http://www.ncbi.nlm.nih.gov/#317
type: UnificationXref
db: Entrez Gene
id: 317

FADD
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8772
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#1676
type: UnificationXref
db: Entrez Gene
id: 1676

.CASP3.INHIBITS.EIF4B.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.EIF4B
control type: INHIBITION
xref: 11274152
data source: Spike

11170436
type: PublicationXref
db: PubMed
id: 11170436
title: An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7

http://www.ncbi.nlm.nih.gov/#5747
type: UnificationXref
db: Entrez Gene
id: 5747

EIF3J_inactive
type: Protein
entity reference: EIF3J

10932250
type: PublicationXref
db: PubMed
id: 10932250
title: Structure of the heterodimeric complex between CAD domains of CAD and ICAD

11359776
type: PublicationXref
db: PubMed
id: 11359776
title: X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes

9930654
type: PublicationXref
db: PubMed
id: 9930654
title: Caspase-3-induced gelsolin fragmentation contributes to actin cytoskeletal collapse, nucleolysis, and apoptosis of vascular smooth muscle cells exposed to proinflammatory cytokines

SREBF2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6721
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#114548
type: UnificationXref
db: Entrez Gene
id: 114548

.CASP10.PROMOTES.CASP3.
type: Catalysis
controller: CASP10
controlled: Proteolytic.Processing.P.CASP10.CASP3
control type: ACTIVATION
xref: 9765224
xref: 11717445
data source: Spike

IL1A_inactive
type: Protein
entity reference: IL1A

http://www.ncbi.nlm.nih.gov/#572
type: UnificationXref
db: Entrez Gene
id: 572

10490026
type: PublicationXref
db: PubMed
id: 10490026
title: Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation

http://www.ncbi.nlm.nih.gov/#578
type: UnificationXref
db: Entrez Gene
id: 578

15300255
type: PublicationXref
db: PubMed
id: 15300255
title: Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function

8358790
type: PublicationXref
db: PubMed
id: 8358790
title: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

.BIRC3.INHIBITS.CASP3.
type: Catalysis
controller: BIRC3
controlled: Physical.Interaction.I.BIRC3.CASP3
control type: INHIBITION
xref: 9384571
xref: 9990849
xref: 12042762
data source: Spike

.CASP9.PROMOTES.CASP7.
type: Catalysis
controller: CASP9
controlled: Proteolytic.Processing.P.CASP9.CASP7
control type: ACTIVATION
xref: 17899380
xref: 9922454
data source: Spike

ALDOA_inactive
type: Protein
entity reference: ALDOA

AKT1
type: Protein
entity reference: AKT1

.Family.IkB....INHIBITS.Complex.NFkB....
type: Catalysis
controller: IkB.family
controlled: Physical.Interaction.I.IkB.NFkB
control type: INHIBITION
xref: 10644043
data source: Spike

APAF1-CASP9 precursor
type: Complex
component: CASP9
component: APAF1
component: CYCS
data source: Spike
display name: apoptosome.complex

http://www.ncbi.nlm.nih.gov/#581
type: UnificationXref
db: Entrez Gene
id: 581

9228058
type: PublicationXref
db: PubMed
id: 9228058
title: Characterization of Fas (Apo-1, CD95)-Fas ligand interaction

BIRC3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#330
organism: Homo sapiens

10469655
type: PublicationXref
db: PubMed
id: 10469655
title: NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes

.BAX.PROMOTES.CYCS.
type: Catalysis
controller: BAX
controlled: Indirect.P.BAX.CYCS
control type: ACTIVATION
xref: 12232790
xref: 11326099
data source: Spike

IL33_inactive
type: Protein
entity reference: IL33

.CASP1.INHIBITS.GAPDH.
type: Catalysis
controller: CASP1
controlled: Proteolytic.Processing.I.CASP1.GAPDH
control type: INHIBITION
xref: 17959595
data source: Spike

9731710
type: PublicationXref
db: PubMed
id: 9731710
title: BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members

.CASP3.INHIBITS.PTK2.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.PTK2
control type: INHIBITION
xref: 9463408
xref: 10224094
data source: Spike

FGF2
type: Protein
entity reference: FGF2

9230442
type: PublicationXref
db: PubMed
id: 9230442
title: X-linked IAP is a direct inhibitor of cell-death proteases

GAPDH_inactive
type: Protein
entity reference: GAPDH

.CYCS.PROMOTES.APAF1.
type: Catalysis
controller: CYCS
controlled: Physical.Interaction.P.CYCS.APAF1
control type: ACTIVATION
xref: 9267021
data source: Spike

http://www.ncbi.nlm.nih.gov/#6721
type: UnificationXref
db: Entrez Gene
id: 6721

.TNFRSF1A.PROMOTES.RIPK1.
type: Catalysis
controller: TNFRSF1A
controlled: Physical.Interaction.P.TNFRSF1A.RIPK1
control type: ACTIVATION
xref: 8612133
data source: Spike

.CARD16.INHIBITS.CASP1.
type: Catalysis
controller: CARD16
controlled: Physical.Interaction.I.CARD16.CASP1
control type: INHIBITION
xref: 11536016
data source: Spike

APAF1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#317
organism: Homo sapiens

GORASP1
type: Protein
entity reference: GORASP1

9422506
type: PublicationXref
db: PubMed
id: 9422506
title: A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

http://www.ncbi.nlm.nih.gov/#2247
type: UnificationXref
db: Entrez Gene
id: 2247

10644043
type: PublicationXref
db: PubMed
id: 10644043
title: Suppression of lipopolysaccharide-induced nuclear factor-kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages

17401638
type: PublicationXref
db: PubMed
id: 17401638
title: Apoptotic cleavage of NuMA at the C-terminal end is related to nuclear disruption and death amplification

CASP5_inactive
type: Protein
entity reference: CASP5

9990849
type: PublicationXref
db: PubMed
id: 9990849
title: IAP family proteins--suppressors of apoptosis

.CRADD.PROMOTES.RIPK1.
type: Catalysis
controller: CRADD
controlled: Physical.Interaction.P.CRADD.RIPK1
control type: ACTIVATION
xref: 9044836
data source: Spike

11069302
type: PublicationXref
db: PubMed
id: 11069302
title: Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin

http://www.ncbi.nlm.nih.gov/#8737
type: UnificationXref
db: Entrez Gene
id: 8737

9153240
type: PublicationXref
db: PubMed
id: 9153240
title: Nonionic detergents induce dimerization among members of the Bcl-2 family

http://www.ncbi.nlm.nih.gov/#8738
type: UnificationXref
db: Entrez Gene
id: 8738

.CASP3.INHIBITS.BCL2.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.BCL2
control type: INHIBITION
xref: 9395403
data source: Spike

.CASP3.INHIBITS.EIF4G1.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.EIF4G1
control type: INHIBITION
xref: 10611228
xref: 9819442
data source: Spike

CASP6_inactive
type: Protein
entity reference: CASP6

.FADD.PROMOTES.RIPK1.
type: Catalysis
controller: FADD
controlled: Physical.Interaction.P.FADD.RIPK1
control type: ACTIVATION
xref: 18485876
data source: Spike

BID
type: Protein
entity reference: BID

9880531
type: PublicationXref
db: PubMed
id: 9880531
title: The role of c-FLIP in modulation of CD95-induced apoptosis

PRKDC_inactive
type: Protein
entity reference: PRKDC

IL1B
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3553
organism: Homo sapiens

12042762
type: PublicationXref
db: PubMed
id: 12042762
title: IAP proteins: blocking the road to death's door

PhysicalInteraction [APAF1 -- CYCS ]
type: MolecularInteraction
participant: APAF1
participant: CYCS
xref: 9267021
xref: 16713569
xref: 10578178

11717445
type: PublicationXref
db: PubMed
id: 11717445
title: Caspase-10 is an initiator caspase in death receptor signaling

LMNA
type: Protein
entity reference: LMNA

11821383
type: PublicationXref
db: PubMed
id: 11821383
title: CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis

NLRP3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#114548
organism: Homo sapiens

.CASP8.PROMOTES.CASP6.
type: Catalysis
controller: CASP8
controlled: Other.P.CASP8.CASP6
control type: ACTIVATION
xref: 18329793
data source: Spike

12198137
type: PublicationXref
db: PubMed
id: 12198137
title: Bcl-XL protects BimEL-induced Bax conformational change and cytochrome C release independent of interacting with Bax or BimEL

9463408
type: PublicationXref
db: PubMed
id: 9463408
title: Caspase-mediated cleavage of focal adhesion kinase pp125FAK and disassembly of focal adhesions in human endothelial cell apoptosis

9463409
type: PublicationXref
db: PubMed
id: 9463409
title: Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis

9765224
type: PublicationXref
db: PubMed
id: 9765224
title: Pro-caspase-3 is a major physiologic target of caspase-8

BCL2L2
type: Protein
entity reference: BCL2L2

Nuclear factor kappa-B
type: Complex
data source: Spike
display name: NFkB.complex

SREBF2
type: Protein
entity reference: SREBF2

CASP1_inactive
type: Protein
entity reference: CASP1

16186808
type: PublicationXref
db: PubMed
id: 16186808
title: Unique and overlapping substrate specificities of caspase-8 and caspase-10

.CASP8.PROMOTES.CASP7.
type: Catalysis
controller: CASP8
controlled: Other.P.CASP8.CASP7
control type: ACTIVATION
xref: 18329793
data source: Spike

9217161
type: PublicationXref
db: PubMed
id: 9217161
title: Inhibition of death receptor signals by cellular FLIP

WSC:F.000019
type: UnificationXref
db: Spike DB
id: WSC:F-000019

myosin II
type: Complex
component: RLC (nonmuscle).family
data source: Spike
display name: myosin II.complex

17959595
type: PublicationXref
db: PubMed
id: 17959595
title: The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock

.FAS.PROMOTES.FADD.
type: Catalysis
controller: FAS
controlled: Physical.Interaction.P.FAS.FADD
control type: ACTIVATION
xref: 8967952
xref: 7536190
xref: 7538907
data source: Spike

BCAR1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#9564
organism: Homo sapiens

ENDOG
type: Protein
entity reference: ENDOG

9111042
type: PublicationXref
db: PubMed
id: 9111042
title: A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members

ROCK1
type: Protein
entity reference: ROCK1

18329793
type: PublicationXref
db: PubMed
id: 18329793
title: TRAIL and cancer therapy

PTK2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5747
organism: Homo sapiens

.CASP3.INHIBITS.EIF4G3.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.EIF4G3
control type: INHIBITION
xref: 10611228
xref: 10672017
data source: Spike

XIAP_inactive
type: Protein
entity reference: XIAP

CASP7
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#840
organism: Homo sapiens

11274152
type: PublicationXref
db: PubMed
id: 11274152
title: Disruption of the interaction of mammalian protein synthesis eukaryotic initiation factor 4B with the poly(A)-binding protein by caspase- and viral protease-mediated cleavages

.CASP3.INHIBITS.EIF3J.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.EIF3J
control type: INHIBITION
xref: 10672017
data source: Spike

15073321
type: PublicationXref
db: PubMed
id: 15073321
title: The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress

EIF4G2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1982
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#6709
type: UnificationXref
db: Entrez Gene
id: 6709

.LRDD.PROMOTES.CRADD.
type: Catalysis
controller: LRDD
controlled: Physical.Interaction.P.LRDD.CRADD
control type: ACTIVATION
xref: 15073321
data source: Spike

NUMA1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4926
organism: Homo sapiens

.TNF.PROMOTES.TNFRSF1A.
type: Catalysis
controller: TNF
controlled: Physical.Interaction.P.TNF.TNFRSF1A
control type: ACTIVATION
xref: 10634209
xref: 19442713
xref: 2158863
data source: Spike

11483855
type: PublicationXref
db: PubMed
id: 11483855
title: Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis

.CASP8.INHIBITS.RIPK1.
type: Catalysis
controller: CASP8
controlled: Proteolytic.Processing.I.CASP8.RIPK1
control type: INHIBITION
xref: 11042193
xref: 12842894
xref: 11002417
xref: 10469655
xref: 11002422
xref: 8657102
data source: Spike

caspases, initiator.family
type: Protein
member physical entity: CASP10
member physical entity: CASP9
member physical entity: CASP2
member physical entity: CASP8
xref: WSC:F.000007
data source: Spike

16713569
type: PublicationXref
db: PubMed
id: 16713569
title: A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration

.AKT1.INHIBITS.CASP9.
type: Catalysis
controller: AKT1
controlled: Phosphorylation.I.AKT1.CASP9
control type: INHIBITION
xref: 9812896
xref: 16341064
data source: Spike

16990137
type: PublicationXref
db: PubMed
id: 16990137
title: Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival

GOLGA3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2802
organism: Homo sapiens

BIRC5
type: Protein
entity reference: BIRC5

10634209
type: PublicationXref
db: PubMed
id: 10634209
title: TNF-induced signaling in apoptosis

GAPDH
type: Protein
entity reference: GAPDH

http://www.ncbi.nlm.nih.gov/#142
type: UnificationXref
db: Entrez Gene
id: 142

CARD18
type: Protein
entity reference: CARD18

9390557
type: PublicationXref
db: PubMed
id: 9390557
title: Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

CARD8
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#22900
organism: Homo sapiens

18485876
type: PublicationXref
db: PubMed
id: 18485876
title: TNF-alpha induces two distinct caspase-8 activation pathways

9742125
type: PublicationXref
db: PubMed
id: 9742125
title: Mutagenesis of the BH3 domain of BAX identifies residues critical for dimerization and killing

myosin II.complex_inactive
type: Protein

.CASP3.INHIBITS.PSIP1.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.PSIP1
control type: INHIBITION
xref: 18708362
data source: Spike

http://www.ncbi.nlm.nih.gov/#8837
type: UnificationXref
db: Entrez Gene
id: 8837

.TRADD.PROMOTES.FADD.
type: Catalysis
controller: TRADD
controlled: Physical.Interaction.P.TRADD.FADD
control type: ACTIVATION
xref: 8565075
data source: Spike

http://www.ncbi.nlm.nih.gov/#2597
type: UnificationXref
db: Entrez Gene
id: 2597

TNF
type: Protein
entity reference: TNF

7834748
type: PublicationXref
db: PubMed
id: 7834748
title: Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

CARD18
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#59082
organism: Homo sapiens

.RIPK1.PROMOTES.FADD.
type: Catalysis
controller: RIPK1
controlled: Physical.Interaction.P.RIPK1.FADD
control type: ACTIVATION
xref: 11002422
data source: Spike

.XIAP.INHIBITS.CASP3.
type: Catalysis
controller: XIAP
controlled: Ubiquitination.I.XIAP.CASP3
control type: INHIBITION
xref: 9230442
xref: 9525868
xref: 11447297
xref: 11927604
data source: Spike

.CASP5.PROMOTES.IL18.
type: Catalysis
controller: CASP5
controlled: Other.P.CASP5.IL18
control type: ACTIVATION
xref: 17039247
data source: Spike

WSC:F.000006
type: UnificationXref
db: Spike DB
id: WSC:F-000006

9812896
type: PublicationXref
db: PubMed
id: 9812896
title: Regulation of cell death protease caspase-9 by phosphorylation

.CASP6.INHIBITS.LMNA.
type: Catalysis
controller: CASP6
controlled: Proteolytic.Processing.I.CASP6.LMNA
control type: INHIBITION
xref: 8710882
data source: Spike

WSC:F.000007
type: UnificationXref
db: Spike DB
id: WSC:F-000007

BIRC6
type: Protein
entity reference: BIRC6

BAK1
type: Protein
entity reference: BAK1

17899380
type: PublicationXref
db: PubMed
id: 17899380
title: Delineation of the caspase-9 signaling cascade

9500443
type: PublicationXref
db: PubMed
id: 9500443
title: CD95 (Fas)-induced caspase-mediated proteolysis of NF-kappaB

17039247
type: PublicationXref
db: PubMed
id: 17039247
title: Apoptosis and caspases regulate death and inflammation in sepsis

BAX
type: Protein
entity reference: BAX

.CARD18.INHIBITS.CASP1.
type: Catalysis
controller: CARD18
controlled: Physical.Interaction.I.CARD18.CASP1
control type: INHIBITION
xref: 11536016
data source: Spike

10224094
type: PublicationXref
db: PubMed
id: 10224094
title: Dephosphorylation of focal adhesion kinase (FAK) and loss of focal contacts precede caspase-mediated cleavage of FAK during apoptosis in renal epithelial cells

15574335
type: PublicationXref
db: PubMed
id: 15574335
title: The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA

9384571
type: PublicationXref
db: PubMed
id: 9384571
title: The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

EIF4G3_inactive
type: Protein
entity reference: EIF4G3

EIF4B
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1975
organism: Homo sapiens

BID_inactive
type: Protein
entity reference: BID

LMNA_inactive
type: Protein
entity reference: LMNA

CASP1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#834
organism: Homo sapiens

SREBF2_inactive
type: Protein
entity reference: SREBF2

PhysicalInteraction [CARD16 -- CARD8 ]
type: MolecularInteraction
participant: CARD16
participant: CARD8
xref: 11821383

.BCL2L11.PROMOTES.BAK1.
type: Catalysis
controller: BCL2L11
controlled: Physical.Interaction.P.BCL2L11.BAK1
control type: ACTIVATION
xref: 12242151
data source: Spike

11002422
type: PublicationXref
db: PubMed
id: 11002422
title: Activation of death-inducing signaling complex (DISC) by pro-apoptotic C-terminal fragment of RIP

TNFRSF1A_inactive
type: Protein
entity reference: TNFRSF1A

.XIAP.INHIBITS.CASP7.
type: Catalysis
controller: XIAP
controlled: Physical.Interaction.I.XIAP.CASP7
control type: INHIBITION
xref: 9230442
xref: 9525868
xref: 11359776
data source: Spike

CASP10
type: Protein
entity reference: CASP10

SPTAN1_inactive
type: Protein
entity reference: SPTAN1

f-actin.complex_inactive
type: Protein

BIRC2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#329
organism: Homo sapiens

10672017
type: PublicationXref
db: PubMed
id: 10672017
title: Changes in integrity and association of eukaryotic protein synthesis initiation factors during apoptosis

.CASP1.PROMOTES.IL1B.
type: Catalysis
controller: CASP1
controlled: Other.P.CASP1.IL1B
control type: ACTIVATION
xref: 17039247
data source: Spike

TNF
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7124
organism: Homo sapiens

GORASP1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#64689
organism: Homo sapiens

11447297
type: PublicationXref
db: PubMed
id: 11447297
title: Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death

.BAK1.PROMOTES.ENDOG.
type: Catalysis
controller: BAK1
controlled: Indirect.P.BAK1.ENDOG
control type: ACTIVATION
xref: 12232790
data source: Spike

11408476
type: PublicationXref
db: PubMed
id: 11408476
title: TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer

CTNNB1_inactive
type: Protein
entity reference: CTNNB1

.Complex.Inflammasome..NLRP1,.CASP1,.PYCARD,.CASP5..PROMOTES.CASP1.
type: Catalysis
controller: Inflammasome.complex
controlled: Physical.Interaction.P.Inflammasome.CASP1
control type: ACTIVATION
xref: 12191486
data source: Spike

ENO1_inactive
type: Protein
entity reference: ENO1

.CASP8.PROMOTES.CASP3.
type: Catalysis
controller: CASP8
controlled: Proteolytic.Processing.P.CASP8.CASP3
control type: ACTIVATION
xref: 9765224
xref: 11437602
data source: Spike

CASP3
type: Protein
entity reference: CASP3

CASP2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#835
organism: Homo sapiens

PhysicalInteraction [NLRP1 -- PYCARD ]
type: MolecularInteraction
participant: PYCARD
participant: NLRP1
xref: 17418785
xref: 11250163

.BCL2L11.INHIBITS.BCL2.
type: Catalysis
controller: BCL2L11
controlled: Physical.Interaction.I.BCL2L11.BCL2
control type: INHIBITION
xref: 9731710
data source: Spike

11042193
type: PublicationXref
db: PubMed
id: 11042193
title: Phospholipase C-gamma 2 couples Bruton's tyrosine kinase to the NF-kappaB signaling pathway in B lymphocytes

.CASP1.INHIBITS.TPI1.
type: Catalysis
controller: CASP1
controlled: Proteolytic.Processing.I.CASP1.TPI1
control type: INHIBITION
xref: 17959595
data source: Spike

http://www.ncbi.nlm.nih.gov/#8717
type: UnificationXref
db: Entrez Gene
id: 8717

11002417
type: PublicationXref
db: PubMed
id: 11002417
title: Activation of the NF-kappaB pathway by caspase 8 and its homologs

http://www.ncbi.nlm.nih.gov/#114769
type: UnificationXref
db: Entrez Gene
id: 114769

11390657
type: PublicationXref
db: PubMed
id: 11390657
title: Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family

.CASP5.PROMOTES.IL1B.
type: Catalysis
controller: CASP5
controlled: Other.P.CASP5.IL1B
control type: ACTIVATION
xref: 17039247
data source: Spike

.CARD8.INHIBITS.CASP9.
type: Catalysis
controller: CARD8
controlled: Physical.Interaction.I.CARD8.CASP9
control type: INHIBITION
xref: 11408476
data source: Spike

8967952
type: PublicationXref
db: PubMed
id: 8967952
title: NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain

9545235
type: PublicationXref
db: PubMed
id: 9545235
title: IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

GAPDH
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2597
organism: Homo sapiens

15507451
type: PublicationXref
db: PubMed
id: 15507451
title: The membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9

.CASP1.PROMOTES.IL1A.
type: Catalysis
controller: CASP1
controlled: Physical.Interaction.P.CASP1.IL1A
control type: ACTIVATION
xref: 18329368
data source: Spike

NUMA1
type: Protein
entity reference: NUMA1

IkB.family
type: Protein
xref: TAU:F.000012
data source: Spike

.Complex.IKK....INHIBITS.Family.IkB....
type: Catalysis
controller: IKK complex
controlled: Phosphorylation.I.IKK.IkB
control type: INHIBITION
xref: 10644043
data source: Spike

9044836
type: PublicationXref
db: PubMed
id: 9044836
title: CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP

LRDD
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#55367
organism: Homo sapiens

8910516
type: PublicationXref
db: PubMed
id: 8910516
title: Phosphatidylserine externalization during CD95-induced apoptosis of cells and cytoplasts requires ICE/CED-3 protease activity

DFFB_inactive
type: Protein
entity reference: DFFB

RIPK1_inactive
type: Protein
entity reference: RIPK1

.CASP7.INHIBITS.DFFA.
type: Catalysis
controller: CASP7
controlled: Proteolytic.Processing.I.CASP7.DFFA
control type: INHIBITION
xref: 10318789
data source: Spike

.XIAP.INHIBITS.CASP9.
type: Catalysis
controller: XIAP
controlled: Physical.Interaction.I.XIAP.CASP9
control type: INHIBITION
xref: 11927604
xref: 12042762
xref: 11390657
data source: Spike

.CASP3.PROMOTES.EIF4G2.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.P.CASP3.EIF4G2
control type: ACTIVATION
xref: 10611228
data source: Spike

.CASP3.INHIBITS.CTNNB1.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.CTNNB1
control type: INHIBITION
xref: 9348292
data source: Spike

11815631
type: PublicationXref
db: PubMed
id: 11815631
title: Caspase-mediated cleavage of the stacking protein GRASP65 is required for Golgi fragmentation during apoptosis

.CASP3.PROMOTES.CASP9.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.P.CASP3.CASP9
control type: ACTIVATION
xref: 8900201
data source: Spike

http://www.ncbi.nlm.nih.gov/#7124
type: UnificationXref
db: Entrez Gene
id: 7124

ENDOG
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2021
organism: Homo sapiens

11106668
type: PublicationXref
db: PubMed
id: 11106668
title: c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment

8702756
type: PublicationXref
db: PubMed
id: 8702756
title: Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)

9606
type: UnificationXref
db: taxonomy
id: 9606

.CASP3.INHIBITS.BCAR1.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.BCAR1
control type: INHIBITION
xref: 11511102
xref: 11447317
data source: Spike

BCAR1
type: Protein
entity reference: BCAR1

8657102
type: PublicationXref
db: PubMed
id: 8657102
title: Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation

11283607
type: PublicationXref
db: PubMed
id: 11283607
title: Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing

.BIRC6.INHIBITS.CASP3.
type: Catalysis
controller: BIRC6
controlled: Physical.Interaction.I.BIRC6.CASP3
control type: INHIBITION
xref: 15200957
data source: Spike

10318789
type: PublicationXref
db: PubMed
id: 10318789
title: Activation of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease). Oligomerization and direct interaction with histone H1

TPI1
type: Protein
entity reference: TPI1

8565075
type: PublicationXref
db: PubMed
id: 8565075
title: TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

http://www.ncbi.nlm.nih.gov/#22985
type: UnificationXref
db: Entrez Gene
id: 22985

.CASP3.INHIBITS.DFFA.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.DFFA
control type: INHIBITION
xref: 9108473
xref: 9422506
data source: Spike

PRKDC
type: Protein
entity reference: PRKDC

.CASP3.PROMOTES.CASP8.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.P.CASP3.CASP8
control type: ACTIVATION
xref: 9922454
data source: Spike

.CFLAR.INHIBITS.CASP8.
type: Catalysis
controller: CFLAR
controlled: Physical.Interaction.I.CFLAR.CASP8
control type: INHIBITION
xref: 9880531
data source: Spike

.BCL2L1.INHIBITS.BAK1.
type: Catalysis
controller: BCL2L1
controlled: Physical.Interaction.I.BCL2L1.BAK1
control type: INHIBITION
xref: 11175750
xref: 18178565
data source: Spike

ROCK1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6093
organism: Homo sapiens

2158863
type: PublicationXref
db: PubMed
id: 2158863
title: Molecular cloning and expression of a receptor for human tumor necrosis factor

http://www.ncbi.nlm.nih.gov/#64689
type: UnificationXref
db: Entrez Gene
id: 64689

.CASP3.PROMOTES.CASP7.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.P.CASP3.CASP7
control type: ACTIVATION
xref: 17899380
data source: Spike

.DFFA.INHIBITS.DFFB.
type: Catalysis
controller: DFFA
controlled: Physical.Interaction.I.DFFA.DFFB
control type: INHIBITION
xref: 10932250
xref: 10527860
data source: Spike

9267021
type: PublicationXref
db: PubMed
id: 9267021
title: Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

12191486
type: PublicationXref
db: PubMed
id: 12191486
title: The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

.CASP3.INHIBITS.BIRC2.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.BIRC2
control type: INHIBITION
xref: 11106668
data source: Spike

10578178
type: PublicationXref
db: PubMed
id: 10578178
title: Apaf1 and the apoptotic machinery

9819442
type: PublicationXref
db: PubMed
id: 9819442
title: Eukaryotic translation initiation factor 4G is targeted for proteolytic cleavage by caspase 3 during inhibition of translation in apoptotic cells

.BCL2L11.PROMOTES.BAX.
type: Catalysis
controller: BCL2L11
controlled: Other.P.BCL2L11.BAX
control type: ACTIVATION
xref: 12198137
xref: 15721256
xref: 12242151
data source: Spike

IkB.family_inactive
type: Protein

11423904
type: PublicationXref
db: PubMed
id: 11423904
title: Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis

9488720
type: PublicationXref
db: PubMed
id: 9488720
title: Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex

TRADD
type: Protein
entity reference: TRADD

DFFA
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1676
organism: Homo sapiens

11583631
type: PublicationXref
db: PubMed
id: 11583631
title: BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

PSIP1
type: Protein
entity reference: PSIP1

8681376
type: PublicationXref
db: PubMed
id: 8681376
title: Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

.BAX.PROMOTES.ENDOG.
type: Catalysis
controller: BAX
controlled: Indirect.P.BAX.ENDOG
control type: ACTIVATION
xref: 12232790
data source: Spike

.BCL2L1.INHIBITS.BAX.
type: Catalysis
controller: BCL2L1
controlled: Physical.Interaction.I.BCL2L1.BAX
control type: INHIBITION
xref: 9742125
xref: 9153240
xref: 11283018
xref: 9111042
xref: 18178565
data source: Spike

.Complex.Inflammasome..NLRP1,.CASP1,.PYCARD,.CASP5..PROMOTES.CASP5.
type: Catalysis
controller: Inflammasome.complex
controlled: Physical.Interaction.P.Inflammasome.CASP5
control type: ACTIVATION
xref: 12191486
data source: Spike

CASP3_inactive
type: Protein
entity reference: CASP3

10791974
type: PublicationXref
db: PubMed
id: 10791974
title: Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis

.CASP2.PROMOTES.BID.
type: Catalysis
controller: CASP2
controlled: Proteolytic.Processing.P.CASP2.BID
control type: ACTIVATION
xref: 11832478
data source: Spike

ENDOG_inactive
type: Protein
entity reference: ENDOG

.BID.INHIBITS.BCL2L2.
type: Catalysis
controller: BID
controlled: Physical.Interaction.I.BID.BCL2L2
control type: INHIBITION
xref: 15694340
data source: Spike

.CASP3.PROMOTES.CASP10.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.P.CASP3.CASP10
control type: ACTIVATION
xref: 9922454
data source: Spike

.CASP3.PROMOTES.CASP6.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.P.CASP3.CASP6
control type: ACTIVATION
xref: 17899380
data source: Spike

ALDOA
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#226
organism: Homo sapiens

16341064
type: PublicationXref
db: PubMed
id: 16341064
title: Exploiting the PI3K/AKT pathway for cancer drug discovery

.GSN.PROMOTES.Complex.f.actin...(ACTG1).
type: Catalysis
controller: GSN
controlled: Other.P.GSN.f.actin
control type: ACTIVATION
xref: 15526166
data source: Spike

NFkB.complex_inactive
type: Protein

11536016
type: PublicationXref
db: PubMed
id: 11536016
title: Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins

7774019
type: PublicationXref
db: PubMed
id: 7774019
title: Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

ITGB4_inactive
type: Protein
entity reference: ITGB4

15200957
type: PublicationXref
db: PubMed
id: 15200957
title: Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase

.CASP3.INHIBITS.NUMA1.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.NUMA1
control type: INHIBITION
xref: 17401638
xref: 9463409
data source: Spike

http://www.ncbi.nlm.nih.gov/#54205
type: UnificationXref
db: Entrez Gene
id: 54205

.BAX.PROMOTES.AIFM1.
type: Catalysis
controller: BAX
controlled: Indirect.P.BAX.AIFM1
control type: ACTIVATION
xref: 12232790
data source: Spike

9850056
type: PublicationXref
db: PubMed
id: 9850056
title: IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs

EIF4G1
type: Protein
entity reference: EIF4G1

http://www.ncbi.nlm.nih.gov/#7132
type: UnificationXref
db: Entrez Gene
id: 7132

GSN
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2934
organism: Homo sapiens

EIF4EBP1
type: Protein
entity reference: EIF4EBP1

15901672
type: PublicationXref
db: PubMed
id: 15901672
title: Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

BAD
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#572
organism: Homo sapiens

9727491
type: PublicationXref
db: PubMed
id: 9727491
title: Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

9727492
type: PublicationXref
db: PubMed
id: 9727492
title: Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

.BAK1.PROMOTES.AIFM1.
type: Catalysis
controller: BAK1
controlled: Indirect.P.BAK1.AIFM1
control type: ACTIVATION
xref: 12232790
data source: Spike

8804412
type: PublicationXref
db: PubMed
id: 8804412
title: CPP32/Yama/apopain cleaves the catalytic component of DNA-dependent protein kinase in the holoenzyme

NLRP1
type: Protein
entity reference: NLRP1

.BID.INHIBITS.BCL2L1.
type: Catalysis
controller: BID
controlled: Physical.Interaction.I.BID.BCL2L1
control type: INHIBITION
xref: 15694340
xref: 9727492
data source: Spike

.FASLG.PROMOTES.FAS.
type: Catalysis
controller: FASLG
controlled: Physical.Interaction.P.FASLG.FAS
control type: ACTIVATION
xref: 9228058
xref: 9126929
data source: Spike

.CASP10.PROMOTES.BID.
type: Catalysis
controller: CASP10
controlled: Proteolytic.Processing.P.CASP10.BID
control type: ACTIVATION
xref: 16186808
data source: Spike

http://www.ncbi.nlm.nih.gov/#11168
type: UnificationXref
db: Entrez Gene
id: 11168

APAF1_inactive
type: Protein
entity reference: APAF1

.CASP7.INHIBITS.PARP1.
type: Catalysis
controller: CASP7
controlled: Proteolytic.Processing.I.CASP7.PARP1
control type: INHIBITION
xref: 16374543
data source: Spike

NLRP3
type: Protein
entity reference: NLRP3

10611228
type: PublicationXref
db: PubMed
id: 10611228
title: A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation

12232790
type: PublicationXref
db: PubMed
id: 12232790
title: The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet

TNFRSF1A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7132
organism: Homo sapiens

IL1F7_inactive
type: Protein
entity reference: IL1F7

PTK2_inactive
type: Protein
entity reference: PTK2

IAP-fam.family
type: Protein
member physical entity: BIRC5
member physical entity: BIRC3
member physical entity: BIRC6
member physical entity: BIRC2
member physical entity: XIAP
xref: TAU:F.000018
data source: Spike

12867423
type: PublicationXref
db: PubMed
id: 12867423
title: Oxidative stress induces nuclear loss of DNA repair proteins Ku70 and Ku80 and apoptosis in pancreatic acinar AR42J cells

CFLAR
type: Protein
entity reference: CFLAR

9126929
type: PublicationXref
db: PubMed
id: 9126929
title: Identification of amino acid residues important for ligand binding to Fas

8710882
type: PublicationXref
db: PubMed
id: 8710882
title: Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis

BCL2
type: Protein
entity reference: BCL2

TNFRSF1A
type: Protein
entity reference: TNFRSF1A

BCAR1_inactive
type: Protein
entity reference: BCAR1

9108473
type: PublicationXref
db: PubMed
id: 9108473
title: DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

9261102
type: PublicationXref
db: PubMed
id: 9261102
title: Activation of caspase-2 in apoptosis

RIPK1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8737
organism: Homo sapiens

EIF3J
type: Protein
entity reference: EIF3J

9395403
type: PublicationXref
db: PubMed
id: 9395403
title: Conversion of Bcl-2 to a Bax-like death effector by caspases

TRADD
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8717
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#10018
type: UnificationXref
db: Entrez Gene
id: 10018

.CASP3.INHIBITS.BIRC6.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.BIRC6
control type: INHIBITION
xref: 15200957
xref: 15507451
data source: Spike

LRDD
type: Protein
entity reference: LRDD

http://www.ncbi.nlm.nih.gov/#8772
type: UnificationXref
db: Entrez Gene
id: 8772

RLC (nonmuscle).family
type: Protein
xref: WSC:F.000019
data source: Spike

.BIRC6.INHIBITS.CASP7.
type: Catalysis
controller: BIRC6
controlled: Physical.Interaction.I.BIRC6.CASP7
control type: INHIBITION
xref: 15200957
data source: Spike

.APAF1.PROMOTES.CASP9.
type: Catalysis
controller: APAF1
controlled: Physical.Interaction.P.APAF1.CASP9
control type: ACTIVATION
xref: 9922454
xref: 9488720
data source: Spike

BIRC2
type: Protein
entity reference: BIRC2

a6b4 integrin
type: Complex
component: ITGB4
data source: Spike
display name: alpha6beta4 integrin.complex

BAX_inactive
type: Protein
entity reference: BAX

.BCL2L2.INHIBITS.BAK1.
type: Catalysis
controller: BCL2L2
controlled: Physical.Interaction.I.BCL2L2.BAK1
control type: INHIBITION
xref: 15901672
xref: 18178565
xref: 10381646
data source: Spike

CASP9
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#842
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#83939
type: UnificationXref
db: Entrez Gene
id: 83939

http://www.ncbi.nlm.nih.gov/#55367
type: UnificationXref
db: Entrez Gene
id: 55367

IL18
type: Protein
entity reference: IL18

PARP1
type: Protein
entity reference: PARP1

18667412
type: PublicationXref
db: PubMed
id: 18667412
title: Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes

PXN_inactive
type: Protein
entity reference: PXN

.PYCARD.PROMOTES.CASP1.
type: Catalysis
controller: PYCARD
controlled: Physical.Interaction.P.PYCARD.CASP1
control type: ACTIVATION
xref: 12191486
data source: Spike

EIF4EBP1_inactive
type: Protein
entity reference: EIF4EBP1

EIF2A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#83939
organism: Homo sapiens

PRKDC
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5591
organism: Homo sapiens

.BAK1.PROMOTES.CYCS.
type: Catalysis
controller: BAK1
controlled: Indirect.P.BAK1.CYCS
control type: ACTIVATION
xref: 12232790
xref: 11326099
data source: Spike

SPTAN1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6709
organism: Homo sapiens

BIRC6_inactive
type: Protein
entity reference: BIRC6

.CASP3.PROMOTES.CASP2.
type: Catalysis
controller: CASP3
controlled: Proteolytic.Processing.P.CASP3.CASP2
control type: ACTIVATION
xref: 9261102
xref: 9922454
data source: Spike

BCL2L1_inactive
type: Protein
entity reference: BCL2L1

CARD16
type: Protein
entity reference: CARD16

FAS
type: Protein
entity reference: FAS

.CARD8.INHIBITS.CASP1.
type: Catalysis
controller: CARD8
controlled: Physical.Interaction.I.CARD8.CASP1
control type: INHIBITION
xref: 11821383
data source: Spike

CASP5
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#838
organism: Homo sapiens

BIRC6
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#57448
organism: Homo sapiens

143236
type: PublicationXref
db: PubMed
id: 143236
title: Nonmuscle contractile proteins: the role of actin and myosin in cell motility and shape determination

FASLG
type: Protein
entity reference: FASLG

GORASP1_inactive
type: Protein
entity reference: GORASP1

11706994
type: PublicationXref
db: PubMed
id: 11706994
title: Apaf1 in developmental apoptosis and cancer: how many ways to die?

ENO1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2023
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#2802
type: UnificationXref
db: Entrez Gene
id: 2802

.BIRC6.INHIBITS.CASP9.
type: Catalysis
controller: BIRC6
controlled: Physical.Interaction.I.BIRC6.CASP9
control type: INHIBITION
xref: 15300255
data source: Spike

XIAP
type: Protein
entity reference: XIAP

http://www.ncbi.nlm.nih.gov/#22861
type: UnificationXref
db: Entrez Gene
id: 22861

11927604
type: PublicationXref
db: PubMed
id: 11927604
title: The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites

.BID.PROMOTES.BAX.
type: Catalysis
controller: BID
controlled: Physical.Interaction.P.BID.BAX
control type: ACTIVATION
xref: 15574335
data source: Spike

CASP3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#836
organism: Homo sapiens