12242151
type: PublicationXref
id: 12242151
db: PubMed
title: Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

.CASP3.INHIBITS.SPTAN1.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.SPTAN1
xref: 8910516
xref: 9624143

HTRA2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#27429

TNFRSF10A_inactive
type: Protein
entity reference: TNFRSF10A

.TNFRSF10A.PROMOTES.TRADD.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: TNFRSF10A
controlled: Physical.Interaction.P.TNFRSF10A.TRADD
xref: 9430227
xref: 9430228

http://www.ncbi.nlm.nih.gov/#2021
type: UnificationXref
id: 2021
db: Entrez Gene

.CASP8.PROMOTES.BID.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: CASP8
controlled: Proteolytic.Processing.P.CASP8.BID
xref: 9727491
xref: 9727492

.PMAIP1.INHIBITS.BCL2.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: PMAIP1
controlled: Physical.Interaction.I.PMAIP1.BCL2
xref: 15725726
xref: 10807576

8900201
type: PublicationXref
id: 8900201
db: PubMed
title: The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32

.RIPK1.PROMOTES.Complex.IKK....
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: RIPK1
controlled: Physical.Interaction.P.RIPK1.IKK
xref: 12654725

SH3GLB1
type: Protein
entity reference: SH3GLB1

7536190
type: PublicationXref
id: 7536190
db: PubMed
title: A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain

.BIRC2.INHIBITS.CASP9.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BIRC2
controlled: Physical.Interaction.I.BIRC2.CASP9
xref: 9545235
xref: 9990849

AIFM1
type: Protein
entity reference: AIFM1

ATP
type: SmallMoleculeReference
xref: http://www.ebi.ac.uk/chebi/#15422

RIPK1
type: Protein
entity reference: RIPK1

PPP1CA
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5499

.EIF4G2.PROMOTES.BIRC2.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: EIF4G2
controlled: Translational.Regulation.P.EIF4G2.BIRC2
xref: 14960583

CASP8_inactive
type: Protein
entity reference: CASP8

.TRAF2.PROMOTES.RIPK1.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: TRAF2
controlled: Ubiquitination.P.TRAF2.RIPK1
xref: 8702708
xref: 8612133
xref: 18981220

.BAD.INHIBITS.BCL2.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BAD
controlled: Physical.Interaction.I.BAD.BCL2
xref: 11583631
xref: 11483855
xref: 9463381
xref: 7834748

http://www.ncbi.nlm.nih.gov/#9131
type: UnificationXref
id: 9131
db: Entrez Gene

GSN
type: Protein
entity reference: GSN

CASP6
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#839

TRAF2_inactive
type: Protein
entity reference: TRAF2

9381178
type: PublicationXref
id: 9381178
db: PubMed
title: Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

MCL1
type: Protein
entity reference: MCL1

10892748
type: PublicationXref
id: 10892748
db: PubMed
title: A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction

RPS6KA1
type: Protein
entity reference: RPS6KA1

19442713
type: PublicationXref
id: 19442713
db: PubMed
title: Dexamethasone protects auditory hair cells against TNFalpha-initiated apoptosis via activation of PI3K/Akt and NFkappaB signaling

CASP6
type: Protein
entity reference: CASP6

CTNNB1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1499

9228018
type: PublicationXref
id: 9228018
db: PubMed
title: FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis

.DIABLO.INHIBITS.BIRC2.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: DIABLO
controlled: Physical.Interaction.I.DIABLO.BIRC2
xref: 10929712

15778222
type: PublicationXref
id: 15778222
db: PubMed
title: Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death

DAPK3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1613

15705586
type: PublicationXref
id: 15705586
db: PubMed
title: Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection

.BIRC2.INHIBITS.CASP7.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BIRC2
controlled: Physical.Interaction.I.BIRC2.CASP7
xref: 9384571

http://www.ncbi.nlm.nih.gov/#2934
type: UnificationXref
id: 2934
db: Entrez Gene

BCL2L1
type: Protein
entity reference: BCL2L1

RLC (nonmuscle).family_inactive
type: Protein

8612133
type: PublicationXref
id: 8612133
db: PubMed
title: TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

14960583
type: PublicationXref
id: 14960583
db: PubMed
title: Translational induction of the inhibitor of apoptosis protein HIAP2 during endoplasmic reticulum stress attenuates cell death and is mediated via an inducible internal ribosome entry site element

.CASP3.PROMOTES.ACIN1.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: CASP3
controlled: Proteolytic.Processing.P.CASP3.ACIN1
xref: 10490026

http://www.ncbi.nlm.nih.gov/#1499
type: UnificationXref
id: 1499
db: Entrez Gene

MCL1_inactive
type: Protein
entity reference: MCL1

.BBC3.INHIBITS.BCL2.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BBC3
controlled: Physical.Interaction.I.BBC3.BCL2
xref: 15694340

CTNNB1
type: Protein
entity reference: CTNNB1

FAS_inactive
type: Protein
entity reference: FAS

.CASP10.INHIBITS.RIPK1.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CASP10
controlled: Proteolytic.Processing.I.CASP10.RIPK1
xref: 16186808

DAPK3
type: Protein
entity reference: DAPK3

EIF4G2_inactive
type: Protein
entity reference: EIF4G2

BID
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#637

.DAPK1.PROMOTES.DAPK3.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: DAPK1
controlled: Phosphorylation.P.DAPK1.DAPK3
xref: 15367680

.TNFRSF10A.PROMOTES.FADD.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: TNFRSF10A
controlled: Physical.Interaction.P.TNFRSF10A.FADD
xref: 9430227
xref: 9430228

9922454
type: PublicationXref
id: 9922454
db: PubMed
title: Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

GSN_inactive
type: Protein
entity reference: GSN

BAX
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#581

.CASP2.INHIBITS.GOLGA3.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CASP2
controlled: Proteolytic.Processing.I.CASP2.GOLGA3
xref: 10791974

http://www.ncbi.nlm.nih.gov/#5499
type: UnificationXref
id: 5499
db: Entrez Gene

SH3GLB1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#51100

.DIABLO.INHIBITS.BIRC3.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: DIABLO
controlled: Physical.Interaction.I.DIABLO.BIRC3
xref: 10929712

14561217
type: PublicationXref
id: 14561217
db: PubMed
title: Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands

EIF2A_inactive
type: Protein
entity reference: EIF2A

EIF3J
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8669

TNFSF10
type: Protein
entity reference: TNFSF10

.BIRC6.INHIBITS.HTRA2.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BIRC6
controlled: Ubiquitination.I.BIRC6.HTRA2
xref: 15781261

EIF2S3
type: Protein
entity reference: EIF2S3

.DIABLO.INHIBITS.BIRC6.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: DIABLO
controlled: Physical.Interaction.I.DIABLO.BIRC6
xref: 15200957

DISC (Primary complex) FADD, CASP8, CASP10
type: Complex
display name: DISC.complex
component: FAS
component: CFLAR
data source: Spike

.DAPK1.INHIBITS.DAPK1.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: DAPK1
controlled: Phosphorylation.I.DAPK1.DAPK1
xref: 11579085

.BAK1.PROMOTES.HTRA2.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: BAK1
controlled: Indirect.P.BAK1.HTRA2
xref: 12232790

.BIRC2.INHIBITS.CASP3.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BIRC2
controlled: Physical.Interaction.I.BIRC2.CASP3
xref: 9384571
xref: 9990849
xref: 12042762

11326099
type: PublicationXref
id: 11326099
db: PubMed
title: Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

11571294
type: PublicationXref
id: 11571294
db: PubMed
title: Tumor necrosis factor-alpha induces Bax-Bak interaction and apoptosis, which is inhibited by adenovirus E1B 19K

EIF4B_inactive
type: Protein
entity reference: EIF4B

.TNFSF10.INHIBITS.TNFRSF10C.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: TNFSF10
controlled: Physical.Interaction.I.TNFSF10.TNFRSF10C
xref: 9082980

DFFB
type: Protein
entity reference: DFFB

.DIABLO.INHIBITS.BIRC5.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: DIABLO
controlled: Physical.Interaction.I.DIABLO.BIRC5
xref: 12660240

.BCL2L2.INHIBITS.BAX.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BCL2L2
controlled: Physical.Interaction.I.BCL2L2.BAX
xref: 18178565

12654725
type: PublicationXref
id: 12654725
db: PubMed
title: The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation

9463381
type: PublicationXref
id: 9463381
db: PubMed
title: The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4

BIRC5
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#332

DFFA_inactive
type: Protein
entity reference: DFFA

ACIN1_inactive
type: Protein
entity reference: ACIN1

http://www.ncbi.nlm.nih.gov/#207
type: UnificationXref
id: 207
db: Entrez Gene

9082980
type: PublicationXref
id: 9082980
db: PubMed
title: The receptor for the cytotoxic ligand TRAIL

CASP10_inactive
type: Protein
entity reference: CASP10

.CFLAR.INHIBITS.FADD.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CFLAR
controlled: Physical.Interaction.I.CFLAR.FADD
xref: 9217161

CYCS
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#54205

.BIRC3.INHIBITS.CASP9.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BIRC3
controlled: Physical.Interaction.I.BIRC3.CASP9
xref: 9545235
xref: 9990849

EIF4G1_inactive
type: Protein
entity reference: EIF4G1

15725726
type: PublicationXref
id: 15725726
db: PubMed
title: Overview of cell death signaling pathways

15367680
type: PublicationXref
id: 15367680
db: PubMed
title: Death-associated protein kinase phosphorylates ZIP kinase, forming a unique kinase hierarchy to activate its cell death functions

.CASP3.INHIBITS.EIF2A.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.EIF2A
xref: 10734073

.DYNLL1.INHIBITS.BCL2L11.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: DYNLL1
controlled: Physical.Interaction.I.DYNLL1.BCL2L11
xref: 14561217
xref: 10198631

FASLG
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#356

XIAP
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#331

CRADD
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8738

http://www.ncbi.nlm.nih.gov/#841
type: UnificationXref
id: 841
db: Entrez Gene

CRADD_inactive
type: Protein
entity reference: CRADD

http://www.ncbi.nlm.nih.gov/#842
type: UnificationXref
id: 842
db: Entrez Gene

CYCS
type: Protein
entity reference: CYCS

http://www.ncbi.nlm.nih.gov/#843
type: UnificationXref
id: 843
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#637
type: UnificationXref
id: 637
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#1613
type: UnificationXref
id: 1613
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#840
type: UnificationXref
id: 840
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#839
type: UnificationXref
id: 839
db: Entrez Gene

CASP2_inactive
type: Protein
entity reference: CASP2

http://www.ncbi.nlm.nih.gov/#835
type: UnificationXref
id: 835
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#836
type: UnificationXref
id: 836
db: Entrez Gene

EIF4G3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8672

.EIF4G2.PROMOTES.BCL2.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: EIF4G2
controlled: Translational.Regulation.P.EIF4G2.BCL2
xref: 18450493

.CASP3.INHIBITS.EIF4EBP1.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.EIF4EBP1
xref: 10672017

9695946
type: PublicationXref
id: 9695946
db: PubMed
title: Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment

.BIRC3.INHIBITS.CASP7.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BIRC3
controlled: Physical.Interaction.I.BIRC3.CASP7
xref: 9384571

.AKT1.INHIBITS.BAD.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: AKT1
controlled: Phosphorylation.I.AKT1.BAD
xref: 14737178
xref: 9346240
xref: 9381178
xref: 16341064

ATG5
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9474

.CASP9.PROMOTES.CASP3.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: CASP9
controlled: Proteolytic.Processing.P.CASP9.CASP3
xref: 9390557

http://www.ncbi.nlm.nih.gov/#1612
type: UnificationXref
id: 1612
db: Entrez Gene

HTRA2_inactive
type: Protein
entity reference: HTRA2

10381646
type: PublicationXref
id: 10381646
db: PubMed
title: Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members

.TRADD.PROMOTES.TRAF2.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: TRADD
controlled: Physical.Interaction.P.TRADD.TRAF2
xref: 10892748
xref: 8702708
xref: 8565075

.BBC3.INHIBITS.BCL2L2.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BBC3
controlled: Physical.Interaction.I.BBC3.BCL2L2
xref: 15694340

EIF2S2_inactive
type: Protein
entity reference: EIF2S2

http://www.ncbi.nlm.nih.gov/#4170
type: UnificationXref
id: 4170
db: Entrez Gene

FADD_inactive
type: Protein
entity reference: FADD

CYCS_inactive
type: Protein
entity reference: CYCS

http://www.ebi.ac.uk/chebi/#15422
type: UnificationXref
id: 15422
db: ChEBI

17158456
type: PublicationXref
id: 17158456
db: PubMed
title: ROCK1 phosphorylates and activates zipper-interacting protein kinase

AIFM1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9131

ACIN1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#22985

GOLGA3
type: Protein
entity reference: GOLGA3

ROCK1_inactive
type: Protein
entity reference: ROCK1

9624143
type: PublicationXref
id: 9624143
db: PubMed
title: Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis

ACIN1
type: Protein
entity reference: ACIN1

15173180
type: PublicationXref
id: 15173180
db: PubMed
title: Direct binding of Fas-associated death domain (FADD) to the tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 is regulated by the death effector domain of FADD

CASP10
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#843

BCL2L11
type: Protein
entity reference: BCL2L11

http://www.ncbi.nlm.nih.gov/#1677
type: UnificationXref
id: 1677
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#1676
type: UnificationXref
id: 1676
db: Entrez Gene

.CASP3.INHIBITS.EIF4B.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.EIF4B
xref: 11274152

.BAD.INHIBITS.BCL2L2.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BAD
controlled: Physical.Interaction.I.BAD.BCL2L2
xref: 10381646

PPP1CA
type: Protein
entity reference: PPP1CA

.TNFSF10.PROMOTES.TNFRSF10B.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: TNFSF10
controlled: Physical.Interaction.P.TNFSF10.TNFRSF10B
xref: 15538968

10932250
type: PublicationXref
id: 10932250
db: PubMed
title: Structure of the heterodimeric complex between CAD domains of CAD and ICAD

TNFRSF10A
type: Protein
entity reference: TNFRSF10A

.CASP10.PROMOTES.CASP3.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: CASP10
controlled: Proteolytic.Processing.P.CASP10.CASP3
xref: 9765224
xref: 11717445

10490026
type: PublicationXref
id: 10490026
db: PubMed
title: Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation

.BAD.INHIBITS.BCL2L1.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BAD
controlled: Physical.Interaction.I.BAD.BCL2L1
xref: 11583631
xref: 11483855
xref: 11494146
xref: 7834748

15300255
type: PublicationXref
id: 15300255
db: PubMed
title: Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function

.BBC3.INHIBITS.BCL2L1.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BBC3
controlled: Physical.Interaction.I.BBC3.BCL2L1
xref: 15694340

.TNFSF10.PROMOTES.TNFRSF10A.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: TNFSF10
controlled: Physical.Interaction.P.TNFSF10.TNFRSF10A
xref: 15538968

.BIRC3.INHIBITS.CASP3.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BIRC3
controlled: Physical.Interaction.I.BIRC3.CASP3
xref: 9384571
xref: 9990849
xref: 12042762

BH3 fam.family
type: Protein
member physical entity: BAD
member physical entity: BBC3
member physical entity: BID
member physical entity: PMAIP1
member physical entity: BCL2L11
data source: Spike
xref: TAU:F.000016

.CASP9.PROMOTES.CASP7.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: CASP9
controlled: Proteolytic.Processing.P.CASP9.CASP7
xref: 17899380
xref: 9922454

9228058
type: PublicationXref
id: 9228058
db: PubMed
title: Characterization of Fas (Apo-1, CD95)-Fas ligand interaction

DAPK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1612

.BAX.PROMOTES.CYCS.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: BAX
controlled: Indirect.P.BAX.CYCS
xref: 12232790
xref: 11326099

.HTRA2.INHIBITS.BIRC3.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: HTRA2
controlled: Physical.Interaction.I.HTRA2.BIRC3
xref: 11583623

9731710
type: PublicationXref
id: 9731710
db: PubMed
title: BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members

9230442
type: PublicationXref
id: 9230442
db: PubMed
title: X-linked IAP is a direct inhibitor of cell-death proteases

.CYCS.PROMOTES.APAF1.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: CYCS
controlled: Physical.Interaction.P.CYCS.APAF1
xref: 9267021

.CASP3.INHIBITS.EIF4G2.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.EIF4G2
xref: 10611228
xref: 10672017

10795740
type: PublicationXref
id: 10795740
db: PubMed
title: The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation

9422506
type: PublicationXref
id: 9422506
db: PubMed
title: A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

9990849
type: PublicationXref
id: 9990849
db: PubMed
title: IAP family proteins--suppressors of apoptosis

.CRADD.PROMOTES.RIPK1.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: CRADD
controlled: Physical.Interaction.P.CRADD.RIPK1
xref: 9044836

http://www.ncbi.nlm.nih.gov/#8737
type: UnificationXref
id: 8737
db: Entrez Gene

9153240
type: PublicationXref
id: 9153240
db: PubMed
title: Nonionic detergents induce dimerization among members of the Bcl-2 family

http://www.ncbi.nlm.nih.gov/#8738
type: UnificationXref
id: 8738
db: Entrez Gene

.CASP3.INHIBITS.EIF4G1.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.EIF4G1
xref: 10611228
xref: 9819442

.HTRA2.INHIBITS.BIRC2.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: HTRA2
controlled: Physical.Interaction.I.HTRA2.BIRC2
xref: 11583623
xref: 11604410

CASP6_inactive
type: Protein
entity reference: CASP6

.FADD.PROMOTES.RIPK1.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: FADD
controlled: Physical.Interaction.P.FADD.RIPK1
xref: 18485876

LMNA
type: Protein
entity reference: LMNA

11717445
type: PublicationXref
id: 11717445
db: PubMed
title: Caspase-10 is an initiator caspase in death receptor signaling

RPS6KA1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6195

15781261
type: PublicationXref
id: 15781261
db: PubMed
title: HtrA2 cleaves Apollon and induces cell death by IAP-binding motif in Apollon-deficient cells

.LRDD.PROMOTES.RIPK1.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: LRDD
controlled: Physical.Interaction.P.LRDD.RIPK1
xref: 16360037

http://www.ncbi.nlm.nih.gov/#8743
type: UnificationXref
id: 8743
db: Entrez Gene

.BCL2L11.INHIBITS.BCL2L2.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BCL2L11
controlled: Physical.Interaction.I.BCL2L11.BCL2L2
xref: 9731710
xref: 9430630

11983683
type: PublicationXref
id: 11983683
db: PubMed
title: Activation of JNK1, RSK2, and MSK1 is involved in serine 112 phosphorylation of Bad by ultraviolet B radiation

.BCL2L11.INHIBITS.BCL2L1.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BCL2L11
controlled: Physical.Interaction.I.BCL2L11.BCL2L1
xref: 9731710
xref: 9430630

BCL2L2
type: Protein
entity reference: BCL2L2

17157251
type: PublicationXref
id: 17157251
db: PubMed
title: The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site

ENDOG
type: Protein
entity reference: ENDOG

.CASP3.INHIBITS.EIF4G3.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.EIF4G3
xref: 10611228
xref: 10672017

http://www.ncbi.nlm.nih.gov/#27113
type: UnificationXref
id: 27113
db: Entrez Gene

CASP7
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#840

TNFRSF10B
type: Protein
entity reference: TNFRSF10B

EIF4G2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1982

.LRDD.PROMOTES.CRADD.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: LRDD
controlled: Physical.Interaction.P.LRDD.CRADD
xref: 15073321

11483855
type: PublicationXref
id: 11483855
db: PubMed
title: Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis

GOLGA3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2802

.BAK1.PROMOTES.BAK1.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: BAK1
controlled: Physical.Interaction.P.BAK1.BAK1
xref: 17157251

10634209
type: PublicationXref
id: 10634209
db: PubMed
title: TNF-induced signaling in apoptosis

http://www.ncbi.nlm.nih.gov/#142
type: UnificationXref
id: 142
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#6197
type: UnificationXref
id: 6197
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#6195
type: UnificationXref
id: 6195
db: Entrez Gene

.BIRC6.INHIBITS.DIABLO.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BIRC6
controlled: Ubiquitination.I.BIRC6.DIABLO
xref: 15300255
xref: 15200957
xref: 15507451

myosin II.complex_inactive
type: Protein

TNF
type: Protein
entity reference: TNF

.HTRA2.INHIBITS.BIRC6.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: HTRA2
controlled: Physical.Interaction.I.HTRA2.BIRC6
xref: 15200957

.XIAP.INHIBITS.CASP3.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: XIAP
controlled: Ubiquitination.I.XIAP.CASP3
xref: 9230442
xref: 9525868
xref: 11447297
xref: 11927604

16360037
type: PublicationXref
id: 16360037
db: PubMed
title: PIDD mediates NF-kappaB activation in response to DNA damage

14600263
type: PublicationXref
id: 14600263
db: PubMed
title: Uncoordinated regulation of stress fibers and focal adhesions by DAP kinase

.CASP6.INHIBITS.LMNA.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CASP6
controlled: Proteolytic.Processing.I.CASP6.LMNA
xref: 8710882

.BAK1.PROMOTES.BAX.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: BAK1
controlled: Physical.Interaction.P.BAK1.BAX
xref: 11571294

BAK1
type: Protein
entity reference: BAK1

17899380
type: PublicationXref
id: 17899380
db: PubMed
title: Delineation of the caspase-9 signaling cascade

9384571
type: PublicationXref
id: 9384571
db: PubMed
title: The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

EIF4G3_inactive
type: Protein
entity reference: EIF4G3

BID_inactive
type: Protein
entity reference: BID

EIF4B
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1975

LMNA_inactive
type: Protein
entity reference: LMNA

DAPK3_inactive
type: Protein
entity reference: DAPK3

DYNLL1
type: Protein
entity reference: DYNLL1

.BCL2L11.PROMOTES.BAK1.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: BCL2L11
controlled: Physical.Interaction.P.BCL2L11.BAK1
xref: 12242151

TNFRSF1A_inactive
type: Protein
entity reference: TNFRSF1A

.XIAP.INHIBITS.CASP7.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: XIAP
controlled: Physical.Interaction.I.XIAP.CASP7
xref: 9230442
xref: 9525868
xref: 11359776

11803371
type: PublicationXref
id: 11803371
db: PubMed
title: The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity

.FADD.PROMOTES.ATG5.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: FADD
controlled: Physical.Interaction.P.FADD.ATG5
xref: 15778222

TNF
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7124

11447297
type: PublicationXref
id: 11447297
db: PubMed
title: Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death

GORASP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#64689

CASP3
type: Protein
entity reference: CASP3

CASP2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#835

11042193
type: PublicationXref
id: 11042193
db: PubMed
title: Phospholipase C-gamma 2 couples Bruton's tyrosine kinase to the NF-kappaB signaling pathway in B lymphocytes

http://www.ncbi.nlm.nih.gov/#8717
type: UnificationXref
id: 8717
db: Entrez Gene

18981220
type: PublicationXref
id: 18981220
db: PubMed
title: TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis

11390657
type: PublicationXref
id: 11390657
db: PubMed
title: Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family

15507451
type: PublicationXref
id: 15507451
db: PubMed
title: The membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9

IkB.family
type: Protein
data source: Spike
xref: TAU:F.000012

9044836
type: PublicationXref
id: 9044836
db: PubMed
title: CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP

BCL2-fam.family
type: Protein
member physical entity: MCL1
member physical entity: BCL2L2
member physical entity: BCL2
member physical entity: BCL2L1
data source: Spike
xref: TAU:F.000015

RIPK1_inactive
type: Protein
entity reference: RIPK1

.XIAP.INHIBITS.CASP9.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: XIAP
controlled: Physical.Interaction.I.XIAP.CASP9
xref: 11927604
xref: 12042762
xref: 11390657

.BAX.PROMOTES.BAX.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: BAX
controlled: Physical.Interaction.P.BAX.BAX
xref: 9670005

.CASP3.INHIBITS.CTNNB1.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.CTNNB1
xref: 9348292

ENDOG
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2021

9606
type: UnificationXref
id: 9606
db: taxonomy

8702756
type: PublicationXref
id: 8702756
db: PubMed
title: Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)

DYNLL1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8655

11583623
type: PublicationXref
id: 11583623
db: PubMed
title: A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

.TNFRSF10A.PROMOTES.RIPK1.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: TNFRSF10A
controlled: Physical.Interaction.P.TNFRSF10A.RIPK1
xref: 9430227

.CASP3.INHIBITS.DFFA.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.DFFA
xref: 9108473
xref: 9422506

.CFLAR.INHIBITS.CASP8.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CFLAR
controlled: Physical.Interaction.I.CFLAR.CASP8
xref: 9880531

9267021
type: PublicationXref
id: 9267021
db: PubMed
title: Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

.DFFA.INHIBITS.DFFB.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: DFFA
controlled: Physical.Interaction.I.DFFA.DFFB
xref: 10932250
xref: 10527860

9819442
type: PublicationXref
id: 9819442
db: PubMed
title: Eukaryotic translation initiation factor 4G is targeted for proteolytic cleavage by caspase 3 during inhibition of translation in apoptotic cells

.BCL2L11.PROMOTES.BAX.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: BCL2L11
controlled: Other.P.BCL2L11.BAX
xref: 12198137
xref: 15721256
xref: 12242151

.Family.RLC.(nonmuscle)....PROMOTES.Complex.myosin.II..Family.RLC.(nonmuscle)....(MYL6).
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: RLC (nonmuscle).family
controlled: Other.P.RLC.(nonmuscle).myosin.II
xref: 10047526

http://www.ncbi.nlm.nih.gov/#9474
type: UnificationXref
id: 9474
db: Entrez Gene

DFFA
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1676

TRAF2
type: Protein
entity reference: TRAF2

TRADD
type: Protein
entity reference: TRADD

11583631
type: PublicationXref
id: 11583631
db: PubMed
title: BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

EIF2S2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8894

10807576
type: PublicationXref
id: 10807576
db: PubMed
title: Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

.BAX.PROMOTES.ENDOG.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: BAX
controlled: Indirect.P.BAX.ENDOG
xref: 12232790

.BCL2L1.INHIBITS.BAX.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BCL2L1
controlled: Physical.Interaction.I.BCL2L1.BAX
xref: 9742125
xref: 9153240
xref: 11283018
xref: 9111042
xref: 18178565

CASP3_inactive
type: Protein
entity reference: CASP3

TNFRSF10C
type: Protein
entity reference: TNFRSF10C

10791974
type: PublicationXref
id: 10791974
db: PubMed
title: Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis

ENDOG_inactive
type: Protein
entity reference: ENDOG

.BID.INHIBITS.BCL2L2.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BID
controlled: Physical.Interaction.I.BID.BCL2L2
xref: 15694340

11579085
type: PublicationXref
id: 11579085
db: PubMed
title: The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism

http://www.ncbi.nlm.nih.gov/#51100
type: UnificationXref
id: 51100
db: Entrez Gene

.CASP3.PROMOTES.CASP10.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: CASP3
controlled: Proteolytic.Processing.P.CASP3.CASP10
xref: 9922454

10047526
type: PublicationXref
id: 10047526
db: PubMed
title: Molecular mechanisms of nonmuscle myosin-II regulation

BCL2L11_inactive
type: Protein
entity reference: BCL2L11

16227588
type: PublicationXref
id: 16227588
db: PubMed
title: Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis

15200957
type: PublicationXref
id: 15200957
db: PubMed
title: Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase

.BBC3.PROMOTES.BAX.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: BBC3
controlled: Physical.Interaction.P.BBC3.BAX
xref: 15574335

10356987
type: PublicationXref
id: 10356987
db: PubMed
title: ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells

9850056
type: PublicationXref
id: 9850056
db: PubMed
title: IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs

EIF4EBP1
type: Protein
entity reference: EIF4EBP1

GSN
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2934

15901672
type: PublicationXref
id: 15901672
db: PubMed
title: Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

BAD
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#572

9727491
type: PublicationXref
id: 9727491
db: PubMed
title: Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

9727492
type: PublicationXref
id: 9727492
db: PubMed
title: Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

.BAX.PROMOTES.HTRA2.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: BAX
controlled: Indirect.P.BAX.HTRA2
xref: 12232790

.BAK1.PROMOTES.AIFM1.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: BAK1
controlled: Indirect.P.BAK1.AIFM1
xref: 12232790

.BID.INHIBITS.BCL2L1.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BID
controlled: Physical.Interaction.I.BID.BCL2L1
xref: 15694340
xref: 9727492

.CASP10.PROMOTES.BID.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: CASP10
controlled: Proteolytic.Processing.P.CASP10.BID
xref: 16186808

.CASP7.INHIBITS.PARP1.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CASP7
controlled: Proteolytic.Processing.I.CASP7.PARP1
xref: 16374543

BBC3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#27113

IAP-fam.family
type: Protein
member physical entity: BIRC5
member physical entity: BIRC3
member physical entity: BIRC6
member physical entity: BIRC2
member physical entity: XIAP
data source: Spike
xref: TAU:F.000018

9126929
type: PublicationXref
id: 9126929
db: PubMed
title: Identification of amino acid residues important for ligand binding to Fas

8710882
type: PublicationXref
id: 8710882
db: PubMed
title: Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis

.DAPK3.PROMOTES.Family.RLC.(nonmuscle)...(MYL12A).
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: DAPK3
controlled: Phosphorylation.P.DAPK3.RLC.(nonmuscle)
xref: 15096528
xref: 10356987
xref: 11781833

9108473
type: PublicationXref
id: 9108473
db: PubMed
title: DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

RIPK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8737

TRADD
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8717

RLC (nonmuscle).family
type: Protein
data source: Spike
xref: WSC:F.000019

http://www.ncbi.nlm.nih.gov/#8772
type: UnificationXref
id: 8772
db: Entrez Gene

HTRA2
type: Protein
entity reference: HTRA2

.APAF1.PROMOTES.CASP9.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: APAF1
controlled: Physical.Interaction.P.APAF1.CASP9
xref: 9922454
xref: 9488720

BIRC2
type: Protein
entity reference: BIRC2

14737178
type: PublicationXref
id: 14737178
db: PubMed
title: JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis

EIF2A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#83939

EIF4EBP1_inactive
type: Protein
entity reference: EIF4EBP1

.CASP3.INHIBITS.EIF2S2.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.EIF2S2
xref: 10672017

SPTAN1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6709

BCL2L1_inactive
type: Protein
entity reference: BCL2L1

BIRC6
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#57448

10198631
type: PublicationXref
id: 10198631
db: PubMed
title: The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

18450493
type: PublicationXref
id: 18450493
db: PubMed
title: DAP5 promotes cap-independent translation of Bcl-2 and CDK1 to facilitate cell survival during mitosis

.TNFRSF10B.PROMOTES.FADD.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: TNFRSF10B
controlled: Physical.Interaction.P.TNFRSF10B.FADD
xref: 9430227
xref: 9430228
xref: 15173180

http://www.ncbi.nlm.nih.gov/#8795
type: UnificationXref
id: 8795
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#8797
type: UnificationXref
id: 8797
db: Entrez Gene

GORASP1_inactive
type: Protein
entity reference: GORASP1

.CASP3.INHIBITS.EIF2S3.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.EIF2S3
xref: 10672017

http://www.ncbi.nlm.nih.gov/#8794
type: UnificationXref
id: 8794
db: Entrez Gene

9430227
type: PublicationXref
id: 9430227
db: PubMed
title: Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway

11927604
type: PublicationXref
id: 11927604
db: PubMed
title: The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites

9430228
type: PublicationXref
id: 9430228
db: PubMed
title: TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB

.BID.PROMOTES.BAX.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: BID
controlled: Physical.Interaction.P.BID.BAX
xref: 15574335

CASP3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#836

http://www.ncbi.nlm.nih.gov/#1968
type: UnificationXref
id: 1968
db: Entrez Gene

16374543
type: PublicationXref
id: 16374543
db: PubMed
title: Nuclear caspase-3 and caspase-7 activation, and poly(ADP-ribose) polymerase cleavage are early events in camptothecin-induced apoptosis

APAF1
type: Protein
entity reference: APAF1

11943866
type: PublicationXref
id: 11943866
db: PubMed
title: The caspase-cleaved DAP5 protein supports internal ribosome entry site-mediated translation of death proteins

11283018
type: PublicationXref
id: 11283018
db: PubMed
title: In vitro selection and characterization of Bcl-X(L)-binding proteins from a mix of tissue-specific mRNA display libraries

.BAX.PROMOTES.DIABLO.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: BAX
controlled: Indirect.P.BAX.DIABLO
xref: 12232790

BAK1_inactive
type: Protein
entity reference: BAK1

.BIRC5.INHIBITS.CASP7.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BIRC5
controlled: Physical.Interaction.I.BIRC5.CASP7
xref: 11170436

http://www.ncbi.nlm.nih.gov/#8655
type: UnificationXref
id: 8655
db: Entrez Gene

7538907
type: PublicationXref
id: 7538907
db: PubMed
title: FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

.BCL2.INHIBITS.BAX.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BCL2
controlled: Other.I.BCL2.BAX
xref: 8358790
xref: 9463381
xref: 9111042

8702708
type: PublicationXref
id: 8702708
db: PubMed
title: Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins

PARP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#142

BCL2L2_inactive
type: Protein
entity reference: BCL2L2

BCL2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#596

11485996
type: PublicationXref
id: 11485996
db: PubMed
title: Identification of a new form of death-associated protein kinase that promotes cell survival

http://www.ncbi.nlm.nih.gov/#1975
type: UnificationXref
id: 1975
db: Entrez Gene

11259440
type: PublicationXref
id: 11259440
db: PubMed
title: Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax

DAPK1
type: Protein
entity reference: DAPK1

15002035
type: PublicationXref
id: 15002035
db: PubMed
title: DAP-kinase-mediated morphological changes are localization dependent and involve myosin-II phosphorylation

9346240
type: PublicationXref
id: 9346240
db: PubMed
title: Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

http://www.ncbi.nlm.nih.gov/#1978
type: UnificationXref
id: 1978
db: Entrez Gene

.CASP3.INHIBITS.GORASP1.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.GORASP1
xref: 11815631

EIF4G1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1981

AKT1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#207

http://www.ncbi.nlm.nih.gov/#1982
type: UnificationXref
id: 1982
db: Entrez Gene

.TRADD.PROMOTES.RIPK1.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: TRADD
controlled: Physical.Interaction.P.TRADD.RIPK1
xref: 8612133

http://www.ncbi.nlm.nih.gov/#1981
type: UnificationXref
id: 1981
db: Entrez Gene

15694340
type: PublicationXref
id: 15694340
db: PubMed
title: Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

.FADD.PROMOTES.CASP8.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: FADD
controlled: Physical.Interaction.P.FADD.CASP8
xref: 8681376

.BIRC5.INHIBITS.CASP9.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BIRC5
controlled: Physical.Interaction.I.BIRC5.CASP9
xref: 11069302

http://www.ncbi.nlm.nih.gov/#8672
type: UnificationXref
id: 8672
db: Entrez Gene

.PMAIP1.PROMOTES.BAX.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: PMAIP1
controlled: Physical.Interaction.P.PMAIP1.BAX
xref: 15705586

DIABLO_inactive
type: Protein
entity reference: DIABLO

EIF4G3
type: Protein
entity reference: EIF4G3

CASP7
type: Protein
entity reference: CASP7

.BCL2.INHIBITS.BAK1.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BCL2
controlled: Physical.Interaction.I.BCL2.BAK1
xref: 9463381

TNFSF10
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8743

http://www.ncbi.nlm.nih.gov/#8669
type: UnificationXref
id: 8669
db: Entrez Gene

PMAIP1
type: Protein
entity reference: PMAIP1

CDK1
type: Protein
entity reference: CDK1

ATG5_inactive
type: Protein
entity reference: ATG5

DFFA
type: Protein
entity reference: DFFA

.RPS6KA3.INHIBITS.BAD.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: RPS6KA3
controlled: Phosphorylation.I.RPS6KA3.BAD
xref: 10558990
xref: 10976111
xref: 11983683

15590671
type: PublicationXref
id: 15590671
db: PubMed
title: A novel caspase-2 complex containing TRAF2 and RIP1

TNFRSF10C_inactive
type: Protein
entity reference: TNFRSF10C

11437602
type: PublicationXref
id: 11437602
db: PubMed
title: [W206R]-procaspase 3: an inactivatable substrate for caspase 8

CASP9_inactive
type: Protein
entity reference: CASP9

AIFM1_inactive
type: Protein
entity reference: AIFM1

BAD
type: Protein
entity reference: BAD

SPTAN1
type: Protein
entity reference: SPTAN1

.SH3GLB1.PROMOTES.BAK1.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: SH3GLB1
controlled: Physical.Interaction.P.SH3GLB1.BAK1
xref: 16227588

.BIRC5.INHIBITS.CASP3.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BIRC5
controlled: Physical.Interaction.I.BIRC5.CASP3
xref: 9850056

10558990
type: PublicationXref
id: 10558990
db: PubMed
title: Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

http://www.ncbi.nlm.nih.gov/#57448
type: UnificationXref
id: 57448
db: Entrez Gene

GOLGA3_inactive
type: Protein
entity reference: GOLGA3

11175750
type: PublicationXref
id: 11175750
db: PubMed
title: Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

BAK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#578

CASP8
type: Protein
entity reference: CASP8

.TNFRSF10A.PROMOTES.TNFRSF10B.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: TNFRSF10A
controlled: Physical.Interaction.P.TNFRSF10A.TNFRSF10B
xref: 9430228

.CASP3.PROMOTES.ROCK1.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: CASP3
controlled: Proteolytic.Processing.P.CASP3.ROCK1
xref: 11283607

BAD_inactive
type: Protein
entity reference: BAD

.CFLAR.INHIBITS.CASP10.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CFLAR
controlled: Physical.Interaction.I.CFLAR.CASP10
xref: 9289491
xref: 9228018

BCL2L1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#598

18178565
type: PublicationXref
id: 18178565
db: PubMed
title: Differential regulation of Bax and Bak by anti-apoptotic Bcl-2 family proteins Bcl-B and Mcl-1

.PPP1CA.PROMOTES.BAD.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: PPP1CA
controlled: Dephosphorylation.P.PPP1CA.BAD
xref: 10811615

9348292
type: PublicationXref
id: 9348292
db: PubMed
title: Dismantling cell-cell contacts during apoptosis is coupled to a caspase-dependent proteolytic cleavage of beta-catenin

11604410
type: PublicationXref
id: 11604410
db: PubMed
title: HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

.CASP3.PROMOTES.GSN.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: CASP3
controlled: Proteolytic.Processing.P.CASP3.GSN
xref: 9323209
xref: 9930654

PIDDosome.complex
type: Complex
component: LRDD
component: CASP2
component: CRADD
data source: Spike

11494146
type: PublicationXref
id: 11494146
db: PubMed
title: BAD/BCL-[X(L)] heterodimerization leads to bypass of G0/G1 arrest

http://www.ncbi.nlm.nih.gov/#7186
type: UnificationXref
id: 7186
db: Entrez Gene

.CRADD.PROMOTES.CASP2.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: CRADD
controlled: Physical.Interaction.P.CRADD.CASP2
xref: 8985253
xref: 9695946

EIF4B
type: Protein
entity reference: EIF4B

http://www.ncbi.nlm.nih.gov/#4000
type: UnificationXref
id: 4000
db: Entrez Gene

EIF4G2
type: Protein
entity reference: EIF4G2

11606597
type: PublicationXref
id: 11606597
db: PubMed
title: Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

Homo sapiens
type: BioSource
xref: 9606

.CASP3.INHIBITS.PARP1.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.PARP1
xref: 7774019

BCL2_inactive
type: Protein
entity reference: BCL2

DFFB
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1677

BCL2L2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#599

9525868
type: PublicationXref
id: 9525868
db: PubMed
title: A single BIR domain of XIAP sufficient for inhibiting caspases

.ROCK1.PROMOTES.Family.RLC.(nonmuscle)...(MYL12A).
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: ROCK1
controlled: Phosphorylation.P.ROCK1.RLC.(nonmuscle)
xref: 11283607
xref: 8702756

CASP7_inactive
type: Protein
entity reference: CASP7

EIF2A
type: Protein
entity reference: EIF2A

http://www.ncbi.nlm.nih.gov/#355
type: UnificationXref
id: 355
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#356
type: UnificationXref
id: 356
db: Entrez Gene

10950869
type: PublicationXref
id: 10950869
db: PubMed
title: tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

BIRC2_inactive
type: Protein
entity reference: BIRC2

TAU:F.000012
type: UnificationXref
id: TAU:F-000012
db: Spike DB

RPS6KA3
type: Protein
entity reference: RPS6KA3

TAU:F.000015
type: UnificationXref
id: TAU:F-000015
db: Spike DB

TAU:F.000016
type: UnificationXref
id: TAU:F-000016
db: Spike DB

10527860
type: PublicationXref
id: 10527860
db: PubMed
title: Study of DFF45 in its role of chaperone and inhibitor: two independent inhibitory domains of DFF40 nuclease activity

10734073
type: PublicationXref
id: 10734073
db: PubMed
title: Identification of caspase 3-mediated cleavage and functional alteration of eukaryotic initiation factor 2alpha in apoptosis

EIF4EBP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1978

CASP8
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#841

TAU:F.000018
type: UnificationXref
id: TAU:F-000018
db: Spike DB

BIRC3_inactive
type: Protein
entity reference: BIRC3

.BID.PROMOTES.BAK1.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: BID
controlled: Physical.Interaction.P.BID.BAK1
xref: 10950869

CFLAR
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8837

.FADD.PROMOTES.CASP10.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: FADD
controlled: Physical.Interaction.P.FADD.CASP10
xref: 11717445

CRADD
type: Protein
entity reference: CRADD

8985253
type: PublicationXref
id: 8985253
db: PubMed
title: RAIDD is a new 'death' adaptor molecule

IKK complex
type: Complex
display name: IKK.complex
data source: Spike

7758105
type: PublicationXref
id: 7758105
db: PubMed
title: The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

CASP2
type: Protein
entity reference: CASP2

.EIF4G2.PROMOTES.CDK1.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: EIF4G2
controlled: Translational.Regulation.P.EIF4G2.CDK1
xref: 18450493

CDK1_inactive
type: Protein
entity reference: CDK1

12842894
type: PublicationXref
id: 12842894
db: PubMed
title: Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway

FAS
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#355

EIF2S3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1968

http://www.ncbi.nlm.nih.gov/#330
type: UnificationXref
id: 330
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#331
type: UnificationXref
id: 331
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#332
type: UnificationXref
id: 332
db: Entrez Gene

10929712
type: PublicationXref
id: 10929712
db: PubMed
title: Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

http://www.ncbi.nlm.nih.gov/#329
type: UnificationXref
id: 329
db: Entrez Gene

ATG5
type: Protein
entity reference: ATG5

18003655
type: PublicationXref
id: 18003655
db: PubMed
title: The eIF4G homolog DAP5/p97 supports the translation of select mRNAs during endoplasmic reticulum stress

EIF2S3_inactive
type: Protein
entity reference: EIF2S3

CASP9
type: Protein
entity reference: CASP9

11781833
type: PublicationXref
id: 11781833
db: PubMed
title: HeLa ZIP kinase induces diphosphorylation of myosin II regulatory light chain and reorganization of actin filaments in nonmuscle cells

BCL2L11
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#10018

.TRAF2.PROMOTES.Complex.IKK...(IKBKB).
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: TRAF2
controlled: Physical.Interaction.P.TRAF2.IKK
xref: 10795740

http://www.ncbi.nlm.nih.gov/#6093
type: UnificationXref
id: 6093
db: Entrez Gene

.CASP2.PROMOTES.RIPK1.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: CASP2
controlled: Physical.Interaction.P.CASP2.RIPK1
xref: 15590671

PARP1_inactive
type: Protein
entity reference: PARP1

.SH3GLB1.PROMOTES.BAX.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: SH3GLB1
controlled: Physical.Interaction.P.SH3GLB1.BAX
xref: 11259440
xref: 16227588

9323209
type: PublicationXref
id: 9323209
db: PubMed
title: Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis

11832478
type: PublicationXref
id: 11832478
db: PubMed
title: Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria

17560374
type: PublicationXref
id: 17560374
db: PubMed
title: XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization

.BCL2L11.INHIBITS.MCL1.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BCL2L11
controlled: Physical.Interaction.I.BCL2L11.MCL1
xref: 15694340
xref: 9731710

9430630
type: PublicationXref
id: 9430630
db: PubMed
title: Bim: a novel member of the Bcl-2 family that promotes apoptosis

10811615
type: PublicationXref
id: 10811615
db: PubMed
title: Protein phosphatase 1alpha is a Ras-activated Bad phosphatase that regulates interleukin-2 deprivation-induced apoptosis

15721256
type: PublicationXref
id: 15721256
db: PubMed
title: BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

.EIF4G2.PROMOTES.XIAP.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: EIF4G2
controlled: Translational.Regulation.P.EIF4G2.XIAP
xref: 11943866

TRADD_inactive
type: Protein
entity reference: TRADD

BIRC3
type: Protein
entity reference: BIRC3

15096528
type: PublicationXref
id: 15096528
db: PubMed
title: ZIP kinase is responsible for the phosphorylation of myosin II and necessary for cell motility in mammalian fibroblasts

http://www.ncbi.nlm.nih.gov/#599
type: UnificationXref
id: 599
db: Entrez Gene

.TNFRSF1A.PROMOTES.TRADD.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: TNFRSF1A
controlled: Physical.Interaction.P.TNFRSF1A.TRADD
xref: 7758105
xref: 8565075

http://www.ncbi.nlm.nih.gov/#596
type: UnificationXref
id: 596
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#5366
type: UnificationXref
id: 5366
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#598
type: UnificationXref
id: 598
db: Entrez Gene

Spike
type: Provenance

LMNA
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4000

10976111
type: PublicationXref
id: 10976111
db: PubMed
title: Protein kinase C theta and epsilon promote T-cell survival by a rsk-dependent phosphorylation and inactivation of BAD

12517802
type: PublicationXref
id: 12517802
db: PubMed
title: Suppression of survivin phosphorylation on Thr34 by flavopiridol enhances tumor cell apoptosis

FADD
type: Protein
entity reference: FADD

FADD
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8772

http://www.ncbi.nlm.nih.gov/#317
type: UnificationXref
id: 317
db: Entrez Gene

TRAF2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7186

11170436
type: PublicationXref
id: 11170436
db: PubMed
title: An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7

EIF3J_inactive
type: Protein
entity reference: EIF3J

http://www.ncbi.nlm.nih.gov/#983
type: UnificationXref
id: 983
db: Entrez Gene

11359776
type: PublicationXref
id: 11359776
db: PubMed
title: X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes

9930654
type: PublicationXref
id: 9930654
db: PubMed
title: Caspase-3-induced gelsolin fragmentation contributes to actin cytoskeletal collapse, nucleolysis, and apoptosis of vascular smooth muscle cells exposed to proinflammatory cytokines

.DAPK1.PROMOTES.Family.RLC.(nonmuscle)...(MYL12A).
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: DAPK1
controlled: Phosphorylation.P.DAPK1.RLC.(nonmuscle)
xref: 11485996
xref: 15002035
xref: 14600263

IKK.complex_inactive
type: Protein

MCL1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4170

http://www.ncbi.nlm.nih.gov/#572
type: UnificationXref
id: 572
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#578
type: UnificationXref
id: 578
db: Entrez Gene

8358790
type: PublicationXref
id: 8358790
db: PubMed
title: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

AKT1
type: Protein
entity reference: AKT1

APAF1-CASP9 precursor
type: Complex
display name: apoptosome.complex
component: CASP9
component: APAF1
component: CYCS
data source: Spike

http://www.ncbi.nlm.nih.gov/#581
type: UnificationXref
id: 581
db: Entrez Gene

BIRC3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#330

10469655
type: PublicationXref
id: 10469655
db: PubMed
title: NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes

EIF2S2
type: Protein
entity reference: EIF2S2

9289491
type: PublicationXref
id: 9289491
db: PubMed
title: CASH, a novel caspase homologue with death effector domains

DIABLO
type: Protein
entity reference: DIABLO

http://www.ncbi.nlm.nih.gov/#27429
type: UnificationXref
id: 27429
db: Entrez Gene

TNFRSF10B_inactive
type: Protein
entity reference: TNFRSF10B

.TNFRSF1A.PROMOTES.RIPK1.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: TNFRSF1A
controlled: Physical.Interaction.P.TNFRSF1A.RIPK1
xref: 8612133

TNFRSF10A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8797

GORASP1
type: Protein
entity reference: GORASP1

APAF1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#317

.CDK1.PROMOTES.BIRC5.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: CDK1
controlled: Phosphorylation.P.CDK1.BIRC5
xref: 11069302
xref: 12517802

10644043
type: PublicationXref
id: 10644043
db: PubMed
title: Suppression of lipopolysaccharide-induced nuclear factor-kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages

11069302
type: PublicationXref
id: 11069302
db: PubMed
title: Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin

.EIF4G2.PROMOTES.EIF4G2.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: EIF4G2
controlled: Translational.Regulation.P.EIF4G2.EIF4G2
xref: 18003655
xref: 11943866

.CASP3.INHIBITS.BCL2.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.BCL2
xref: 9395403

BID
type: Protein
entity reference: BID

9880531
type: PublicationXref
id: 9880531
db: PubMed
title: The role of c-FLIP in modulation of CD95-induced apoptosis

12042762
type: PublicationXref
id: 12042762
db: PubMed
title: IAP proteins: blocking the road to death's door

.RPS6KA1.INHIBITS.BAD.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: RPS6KA1
controlled: Phosphorylation.I.RPS6KA1.BAD
xref: 18039929

12198137
type: PublicationXref
id: 12198137
db: PubMed
title: Bcl-XL protects BimEL-induced Bax conformational change and cytochrome C release independent of interacting with Bax or BimEL

.BAK1.PROMOTES.DIABLO.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: BAK1
controlled: Indirect.P.BAK1.DIABLO
xref: 12232790

9765224
type: PublicationXref
id: 9765224
db: PubMed
title: Pro-caspase-3 is a major physiologic target of caspase-8

.LRDD.PROMOTES.CASP2.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: LRDD
controlled: Physical.Interaction.P.LRDD.CASP2
xref: 15073321

16186808
type: PublicationXref
id: 16186808
db: PubMed
title: Unique and overlapping substrate specificities of caspase-8 and caspase-10

.CASP8.PROMOTES.CASP7.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: CASP8
controlled: Other.P.CASP8.CASP7
xref: 18329793

myosin II
type: Complex
display name: myosin II.complex
component: RLC (nonmuscle).family
data source: Spike

WSC:F.000019
type: UnificationXref
id: WSC:F-000019
db: Spike DB

9217161
type: PublicationXref
id: 9217161
db: PubMed
title: Inhibition of death receptor signals by cellular FLIP

http://www.ncbi.nlm.nih.gov/#56616
type: UnificationXref
id: 56616
db: Entrez Gene

.FAS.PROMOTES.FADD.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: FAS
controlled: Physical.Interaction.P.FAS.FADD
xref: 8967952
xref: 7536190
xref: 7538907

9111042
type: PublicationXref
id: 9111042
db: PubMed
title: A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members

ROCK1
type: Protein
entity reference: ROCK1

18329793
type: PublicationXref
id: 18329793
db: PubMed
title: TRAIL and cancer therapy

XIAP_inactive
type: Protein
entity reference: XIAP

11274152
type: PublicationXref
id: 11274152
db: PubMed
title: Disruption of the interaction of mammalian protein synthesis eukaryotic initiation factor 4B with the poly(A)-binding protein by caspase- and viral protease-mediated cleavages

.CASP3.INHIBITS.EIF3J.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.EIF3J
xref: 10672017

15073321
type: PublicationXref
id: 15073321
db: PubMed
title: The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress

BIRC5_inactive
type: Protein
entity reference: BIRC5

http://www.ncbi.nlm.nih.gov/#6709
type: UnificationXref
id: 6709
db: Entrez Gene

.TNF.PROMOTES.TNFRSF1A.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: TNF
controlled: Physical.Interaction.P.TNF.TNFRSF1A
xref: 10634209
xref: 19442713
xref: 2158863

.CASP8.INHIBITS.RIPK1.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CASP8
controlled: Proteolytic.Processing.I.CASP8.RIPK1
xref: 11042193
xref: 12842894
xref: 11002417
xref: 10469655
xref: 11002422
xref: 8657102

BIRC5
type: Protein
entity reference: BIRC5

18485876
type: PublicationXref
id: 18485876
db: PubMed
title: TNF-alpha induces two distinct caspase-8 activation pathways

9390557
type: PublicationXref
id: 9390557
db: PubMed
title: Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

9742125
type: PublicationXref
id: 9742125
db: PubMed
title: Mutagenesis of the BH3 domain of BAX identifies residues critical for dimerization and killing

http://www.ncbi.nlm.nih.gov/#8837
type: UnificationXref
id: 8837
db: Entrez Gene

TNFRSF10C
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8794

.TRADD.PROMOTES.FADD.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: TRADD
controlled: Physical.Interaction.P.TRADD.FADD
xref: 8565075

DAPK1_inactive
type: Protein
entity reference: DAPK1

7834748
type: PublicationXref
id: 7834748
db: PubMed
title: Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

.RIPK1.PROMOTES.FADD.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: RIPK1
controlled: Physical.Interaction.P.RIPK1.FADD
xref: 11002422

BIRC6
type: Protein
entity reference: BIRC6

BAX
type: Protein
entity reference: BAX

15574335
type: PublicationXref
id: 15574335
db: PubMed
title: The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA

9670005
type: PublicationXref
id: 9670005
db: PubMed
title: Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

TNFRSF10B
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8795

11002422
type: PublicationXref
id: 11002422
db: PubMed
title: Activation of death-inducing signaling complex (DISC) by pro-apoptotic C-terminal fragment of RIP

CASP10
type: Protein
entity reference: CASP10

SPTAN1_inactive
type: Protein
entity reference: SPTAN1

10672017
type: PublicationXref
id: 10672017
db: PubMed
title: Changes in integrity and association of eukaryotic protein synthesis initiation factors during apoptosis

BIRC2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#329

.BAK1.PROMOTES.ENDOG.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: BAK1
controlled: Indirect.P.BAK1.ENDOG
xref: 12232790

CTNNB1_inactive
type: Protein
entity reference: CTNNB1

.ATP.PROMOTES.APAF1.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: ATP
controlled: Physical.Interaction.P.ATP.APAF1
xref: 9390557

.CASP8.PROMOTES.CASP3.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: CASP8
controlled: Proteolytic.Processing.P.CASP8.CASP3
xref: 9765224
xref: 11437602

15538968
type: PublicationXref
id: 15538968
db: PubMed
title: Following a TRAIL: update on a ligand and its five receptors

.BCL2L11.INHIBITS.BCL2.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BCL2L11
controlled: Physical.Interaction.I.BCL2L11.BCL2
xref: 9731710

11002417
type: PublicationXref
id: 11002417
db: PubMed
title: Activation of the NF-kappaB pathway by caspase 8 and its homologs

18039929
type: PublicationXref
id: 18039929
db: PubMed
title: Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival

9545235
type: PublicationXref
id: 9545235
db: PubMed
title: IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

8967952
type: PublicationXref
id: 8967952
db: PubMed
title: NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain

.CASP2.PROMOTES.TRAF2.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: CASP2
controlled: Physical.Interaction.P.CASP2.TRAF2
xref: 15590671

PMAIP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5366

.Complex.IKK....INHIBITS.Family.IkB....
type: Catalysis
control type: INHIBITION
data source: Spike
controller: IKK complex
controlled: Phosphorylation.I.IKK.IkB
xref: 10644043

LRDD
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#55367

.PMAIP1.INHIBITS.MCL1.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: PMAIP1
controlled: Physical.Interaction.I.PMAIP1.MCL1
xref: 15694340

DFFB_inactive
type: Protein
entity reference: DFFB

8910516
type: PublicationXref
id: 8910516
db: PubMed
title: Phosphatidylserine externalization during CD95-induced apoptosis of cells and cytoplasts requires ICE/CED-3 protease activity

.CASP7.INHIBITS.DFFA.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CASP7
controlled: Proteolytic.Processing.I.CASP7.DFFA
xref: 10318789

11815631
type: PublicationXref
id: 11815631
db: PubMed
title: Caspase-mediated cleavage of the stacking protein GRASP65 is required for Golgi fragmentation during apoptosis

.CASP3.PROMOTES.CASP9.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: CASP3
controlled: Proteolytic.Processing.P.CASP3.CASP9
xref: 8900201

http://www.ncbi.nlm.nih.gov/#7124
type: UnificationXref
id: 7124
db: Entrez Gene

11106668
type: PublicationXref
id: 11106668
db: PubMed
title: c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment

8657102
type: PublicationXref
id: 8657102
db: PubMed
title: Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation

.BIRC6.INHIBITS.CASP3.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BIRC6
controlled: Physical.Interaction.I.BIRC6.CASP3
xref: 15200957

11283607
type: PublicationXref
id: 11283607
db: PubMed
title: Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing

10318789
type: PublicationXref
id: 10318789
db: PubMed
title: Activation of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease). Oligomerization and direct interaction with histone H1

http://www.ncbi.nlm.nih.gov/#22985
type: UnificationXref
id: 22985
db: Entrez Gene

8565075
type: PublicationXref
id: 8565075
db: PubMed
title: TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

.CASP3.PROMOTES.CASP8.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: CASP3
controlled: Proteolytic.Processing.P.CASP3.CASP8
xref: 9922454

ROCK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6093

.BCL2L1.INHIBITS.BAK1.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BCL2L1
controlled: Physical.Interaction.I.BCL2L1.BAK1
xref: 11175750
xref: 18178565

2158863
type: PublicationXref
id: 2158863
db: PubMed
title: Molecular cloning and expression of a receptor for human tumor necrosis factor

ATP
type: SmallMolecule
entity reference: ATP

http://www.ncbi.nlm.nih.gov/#64689
type: UnificationXref
id: 64689
db: Entrez Gene

.CASP3.PROMOTES.CASP7.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: CASP3
controlled: Proteolytic.Processing.P.CASP3.CASP7
xref: 17899380

.CASP3.INHIBITS.BIRC2.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.BIRC2
xref: 11106668

IkB.family_inactive
type: Protein

9488720
type: PublicationXref
id: 9488720
db: PubMed
title: Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex

8681376
type: PublicationXref
id: 8681376
db: PubMed
title: Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

.CASP9.INHIBITS.BIRC6.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CASP9
controlled: Proteolytic.Processing.I.CASP9.BIRC6
xref: 15507451

CDK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#983

.CASP2.PROMOTES.BID.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: CASP2
controlled: Proteolytic.Processing.P.CASP2.BID
xref: 11832478

.CASP3.PROMOTES.CASP6.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: CASP3
controlled: Proteolytic.Processing.P.CASP3.CASP6
xref: 17899380

RPS6KA3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6197

16341064
type: PublicationXref
id: 16341064
db: PubMed
title: Exploiting the PI3K/AKT pathway for cancer drug discovery

7774019
type: PublicationXref
id: 7774019
db: PubMed
title: Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

http://www.ncbi.nlm.nih.gov/#54205
type: UnificationXref
id: 54205
db: Entrez Gene

.BAX.PROMOTES.AIFM1.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: BAX
controlled: Indirect.P.BAX.AIFM1
xref: 12232790

EIF4G1
type: Protein
entity reference: EIF4G1

http://www.ncbi.nlm.nih.gov/#7132
type: UnificationXref
id: 7132
db: Entrez Gene

.HTRA2.INHIBITS.XIAP.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: HTRA2
controlled: Physical.Interaction.I.HTRA2.XIAP
xref: 11604410
xref: 11803371
xref: 11606597

.FASLG.PROMOTES.FAS.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: FASLG
controlled: Physical.Interaction.P.FASLG.FAS
xref: 9228058
xref: 9126929

APAF1_inactive
type: Protein
entity reference: APAF1

TNFRSF1A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7132

12232790
type: PublicationXref
id: 12232790
db: PubMed
title: The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet

10611228
type: PublicationXref
id: 10611228
db: PubMed
title: A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation

.DIABLO.INHIBITS.XIAP.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: DIABLO
controlled: Physical.Interaction.I.DIABLO.XIAP
xref: 17560374
xref: 10929712

.Family.IAP.fam..BIRC2,.BIRC3,.XIAP,.BIRC5,.BIRC6..INHIBITS.CASP3.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: IAP-fam.family
controlled: Physical.Interaction.I.IAP.fam.CASP3
xref: 9990849

CFLAR
type: Protein
entity reference: CFLAR

.MCL1.INHIBITS.BAK1.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: MCL1
controlled: Physical.Interaction.I.MCL1.BAK1
xref: 15901672

.ROCK1.PROMOTES.DAPK3.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: ROCK1
controlled: Phosphorylation.P.ROCK1.DAPK3
xref: 17158456

BCL2
type: Protein
entity reference: BCL2

TNFRSF1A
type: Protein
entity reference: TNFRSF1A

9261102
type: PublicationXref
id: 9261102
db: PubMed
title: Activation of caspase-2 in apoptosis

EIF3J
type: Protein
entity reference: EIF3J

http://www.ncbi.nlm.nih.gov/#10018
type: UnificationXref
id: 10018
db: Entrez Gene

9395403
type: PublicationXref
id: 9395403
db: PubMed
title: Conversion of Bcl-2 to a Bax-like death effector by caspases

.CASP3.INHIBITS.BIRC6.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CASP3
controlled: Proteolytic.Processing.I.CASP3.BIRC6
xref: 15200957
xref: 15507451

LRDD
type: Protein
entity reference: LRDD

.TNFRSF10B.PROMOTES.TRADD.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: TNFRSF10B
controlled: Physical.Interaction.P.TNFRSF10B.TRADD
xref: 9430227
xref: 9430228

.BIRC6.INHIBITS.CASP7.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BIRC6
controlled: Physical.Interaction.I.BIRC6.CASP7
xref: 15200957

BAX_inactive
type: Protein
entity reference: BAX

.BCL2L2.INHIBITS.BAK1.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BCL2L2
controlled: Physical.Interaction.I.BCL2L2.BAK1
xref: 15901672
xref: 18178565
xref: 10381646

CASP9
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#842

http://www.ncbi.nlm.nih.gov/#83939
type: UnificationXref
id: 83939
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#55367
type: UnificationXref
id: 55367
db: Entrez Gene

PARP1
type: Protein
entity reference: PARP1

BBC3
type: Protein
entity reference: BBC3

.BAK1.PROMOTES.CYCS.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: BAK1
controlled: Indirect.P.BAK1.CYCS
xref: 12232790
xref: 11326099

.CASP3.PROMOTES.CASP2.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: CASP3
controlled: Proteolytic.Processing.P.CASP3.CASP2
xref: 9261102
xref: 9922454

BIRC6_inactive
type: Protein
entity reference: BIRC6

.EIF4G2.PROMOTES.APAF1.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: EIF4G2
controlled: Translational.Regulation.P.EIF4G2.APAF1
xref: 11943866

FAS
type: Protein
entity reference: FAS

.TNFRSF10B.PROMOTES.RIPK1.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: TNFRSF10B
controlled: Physical.Interaction.P.TNFRSF10B.RIPK1
xref: 9430227

DIABLO
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#56616

.BBC3.INHIBITS.MCL1.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BBC3
controlled: Physical.Interaction.I.BBC3.MCL1
xref: 15694340

FASLG
type: Protein
entity reference: FASLG

.BIRC6.INHIBITS.CASP9.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BIRC6
controlled: Physical.Interaction.I.BIRC6.CASP9
xref: 15300255

http://www.ncbi.nlm.nih.gov/#2802
type: UnificationXref
id: 2802
db: Entrez Gene

XIAP
type: Protein
entity reference: XIAP

12660240
type: PublicationXref
id: 12660240
db: PubMed
title: Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis

http://www.ncbi.nlm.nih.gov/#8894
type: UnificationXref
id: 8894
db: Entrez Gene