Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice
Functional characterization of human nucleosome assembly protein 1-like proteins as histone chaperones
Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1
In vivo recruitment of XPC to UV-induced cyclobutane pyrimidine dimers by the DDB2 gene product
Deacetylation of p53 modulates its effect on cell growth and apoptosis
Cockayne syndrome group B protein (CSB) plays a general role in chromatin maintenance and remodeling
Acetylation of H2AX on lysine 36 plays a key role in the DNA double-strand break repair pathway
Polymorphic TP53BP1 and TP53 gene interactions associated with risk of squamous cell carcinoma of the head and neck
DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics
Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells
Ku heterodimer (Ku-70-ku-80) XRCC6-XRCC5
ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage
The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH
Tip60 acetylates six lysines of a specific class in core histones in vitro
Histone lysine demethylases: emerging roles in development, physiology and disease
Evidence that low doses of Taxol enhance the functional transactivatory properties of p53 on p21 waf promoter in MCF-7 breast cancer cells
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response
The SANT domain of p400 ATPase represses acetyltransferase activity and coactivator function of TIP60 in basal p21 gene expression
Acetylation of WRN protein regulates its stability by inhibiting ubiquitination
Microcephalin regulates BRCA2 and Rad51-associated DNA double-strand break repair
p300-mediated Acetylation of Histone H3 Lysine 56 Functions in DNA Damage Response in Mammals
Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation
HMGN proteins act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility
Runx2 recruits p300 to mediate parathyroid hormone's effects on histone acetylation and transcriptional activation of the matrix metalloproteinase-13 gene
ATR kinase as master regulator of nucleotide excision repair during S phase of the cell cycle
KAP1 regulates type I interferon/STAT1-mediated IRF-1 gene expression
CBP/p300-mediated acetylation of histone H3 on lysine 56
The histone methyltransferase SET8 is required for S-phase progression
Regulation of apoptosis by PML and the PML-NBs
Role of the tumor suppressor PTEN in antioxidant responsive element-mediated transcription and associated histone modifications
Activation and regulation of ATM kinase activity in response to DNA double-strand breaks
SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1
Phosphorylation of human high mobility group N1 protein by protein kinase CK2
Gadd45a contributes to p53 stabilization in response to DNA damage
Human SNF5/INI1, a component of the human SWI/SNF chromatin remodeling complex, promotes nucleotide excision repair by influencing ATM recruitment and downstream H2AX phosphorylation
Chk1 in the DNA damage response: conserved roles from yeasts to mammals
Leucine zipper-like domain is required for tumor suppressor ING2-mediated nucleotide excision repair and apoptosis
Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin
Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins
Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response
The many substrates and functions of ATM
Cockayne syndrome B protein (CSB): linking p53, HIF-1 and p300 to robustness, lifespan, cancer and cell fate decisions
DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression
IntAct--open source resource for molecular interaction data
Physical interaction of two cancer-testis antigens, MAGE-C1 (CT7) and NY-ESO-1 (CT6)
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
Enhanced phosphorylation of p53 by ATM in response to DNA damage
p53 is a chromatin accessibility factor for nucleotide excision repair of DNA damage
Acetylation of novel sites in the nucleosomal binding domain of chromosomal protein HMG-14 by p300 alters its interaction with nucleosomes
Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism
The impact of heterochromatin on DSB repair
PhysicalInteraction [Family H1 {} -- Family HP1 {CBX1} ]
Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway
New nomenclature for chromatin-modifying enzymes
Distinct BRCT domains in Mcph1/Brit1 mediate ionizing radiation-induced focus formation and centrosomal localization
Histone modifications: crucial elements for damage response and chromatin restoration
Increased mitotic phosphorylation of histone H3 attributable to AIM-1/Aurora-B overexpression contributes to chromosome number instability
Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex
Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription
DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity
Chromosomal protein HMGN1 enhances the acetylation of lysine 14 in histone H3
SIRT1 promotes DNA repair activity and deacetylation of Ku70
Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer
ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation
Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells
Ubiquitin and SUMO systems in the regulation of mitotic checkpoints
xeroderma pigmentosum complementation group E
Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage
The p48 subunit of the damaged-DNA binding protein DDB associates with the CBP/p300 family of histone acetyltransferase
PARP-1 Regulates Chromatin Structure and Transcription through a KDM5B-Dependent Pathway
Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double strand breaks
H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation
Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression
Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription
MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14
Extensive ssDNA end formation at DNA double-strand breaks in non-homologous end-joining deficient cells during the S phase
Histone deacetylase 10 relieves repression on the melanogenic program by maintaining the deacetylation status of repressors
Modulation of nucleotide excision repair by mammalian SWI/SNF chromatin-remodeling complex
A cooperative activation loop among SWI/SNF, gamma-H2AX and H3 acetylation for DNA double-strand break repair
Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
Differential regulation of mitogen- and stress-activated protein kinase-1 and -2 (MSK1 and MSK2) by CK2 following UV radiation
Regulation of DNA repair throughout the cell cycle
Gadd45a, a p53- and BRCA1-regulated stress protein, in cellular response to DNA damage
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation
Cell differentiation induces TIF1beta association with centromeric heterochromatin via an HP1 interaction
Catalysis and substrate selection by histone/protein lysine acetyltransferases
Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor
Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain
Chromatin remodelling beyond transcription: the INO80 and SWR1 complexes
DDB1 maintains genome integrity through regulation of Cdt1
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
The accessibility of histone H3 tails in chromatin modulates their acetylation by P300/CBP-associated factor
Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
Role of the mammalian SWI/SNF chromatin remodeling complex in the cellular response to UV damage
Structural insights into human KAP1 PHD finger-bromodomain and its role in gene silencing
hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells
BRIT1/MCPH1 links chromatin remodelling to DNA damage response
A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein
ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses
New players in the BRCA1-mediated DNA damage responsive pathway
Chromatin dynamics coupled to DNA repair
Phosphorylation of p300 by ATM controls the stability of NBS1
MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair
ATP-dependent chromatin remodeling factors and DNA damage repair
Rapid activation of ATR by ionizing radiation requires ATM and Mre11
ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage
Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks
A human protein-protein interaction network: a resource for annotating the proteome
A CAF-1-PCNA-mediated chromatin assembly pathway triggered by sensing DNA damage
ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation
Preferential dimethylation of histone H4 lysine 20 by Suv4-20
Pericentric heterochromatin becomes enriched with H2A.Z during early mammalian development
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
KRAB-containing zinc-finger repressor proteins
ATM associates with and phosphorylates p53: mapping the region of interaction
Expression of p53R2, newly p53 target in oral normal epithelium, epithelial dysplasia and squamous cell carcinoma.
The expanding field of poly(ADP-ribosyl)ation reactions. 'Protein Modifications: Beyond the Usual Suspects' Review Series
MTA1-mediated transcriptional repression of BRCA1 tumor suppressor gene
Involvement of human MOF in ATM function
Crosstalk between histone modifications during the DNA damage response
The ATM-mediated DNA-damage response: taking shape
Towards a proteome-scale map of the human protein-protein interaction network
STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage
PhysicalInteraction [Family H1 {} -- SIRT1 ]
PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing
Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies
Role of histone H2A ubiquitination in Polycomb silencing
Monoubiquitylation of H2A.Z distinguishes its association with euchromatin or facultative heterochromatin
Chk1 and Chk2 kinases in checkpoint control and cancer
Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes
PhysicalInteraction [ERCC8 -- Complex TFIIH {} ]
DDB1-DDB2-RBX1-CUL4A ubiquitine ligase E3 complex
Tip60 in DNA damage response and growth control: many tricks in one HAT
MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation
CSB protein is (a direct target of HIF-1 and) a critical mediator of the hypoxic response
Poly ADP-ribosylation: a histone shuttle mechanism in DNA excision repair
Histone ubiquitination associates with BRCA1-dependent DNA damage response
setdb1: a novel kap-1 associated hustone h3, lysin 9 specific methyltransferasethat contributes to hp1 mediated silencing of euchromatic genes by krab zinc finger proteins
Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit
HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP/p300 and P/CAF-dependent p53 acetylation
Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1
Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4
Human claspin is required for replication checkpoint control
Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response
gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes