.Complex.RNF20.RNF40..RNF20,.RNF40..PROMOTES.Family.H2B...(HIST1H2BJ).
type: Catalysis
controller: RNF20-RNF40.complex
data source: Spike
xref: 18614047
controlled: Ubiquitination.P.RNF20.RNF40.H2B
control type: ACTIVATION

RNF168_inactive
type: Protein
entity reference: RNF168

TP53BP1
type: Protein
entity reference: TP53BP1

SETDB1
type: Protein
entity reference: SETDB1

.ATM.PROMOTES.CHEK1.
type: Catalysis
controller: ATM
data source: Spike
xref: 17525332
xref: 11252893
controlled: Phosphorylation.P.ATM.CHEK1
control type: ACTIVATION

http://www.ncbi.nlm.nih.gov/#5111
type: UnificationXref
id: 5111
db: Entrez Gene

CDKN1A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1026
organism: Homo sapiens

CAF-1.complex_inactive
type: Protein

EP300
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2033
organism: Homo sapiens

RNF8_inactive
type: Protein
entity reference: RNF8

.SETDB1.INHIBITS.Family.H3...(HIST1H3F).
type: Catalysis
controller: SETDB1
data source: Spike
xref: 11791185
xref: 11959841
controlled: Methylation.I.SETDB1.H3
control type: INHIBITION

PARP1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#142
organism: Homo sapiens

SETD8
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#387893
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#1387
type: UnificationXref
id: 1387
db: Entrez Gene

HP1.family_inactive
type: Protein

PhysicalInteraction [CDKN1A -- PCNA ]
type: MolecularInteraction
participant: CDKN1A
participant: PCNA
xref: 16189514
xref: 16616141

10859164
type: PublicationXref
title: Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
id: 10859164
db: PubMed

10859163
type: PublicationXref
title: Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice
id: 10859163
db: PubMed

.MTA2.INHIBITS.TP53.
type: Catalysis
controller: MTA2
data source: Spike
xref: 11099047
controlled: Other.I.MTA2.TP53
control type: INHIBITION

20002496
type: PublicationXref
title: Functional characterization of human nucleosome assembly protein 1-like proteins as histone chaperones
id: 20002496
db: PubMed

.EP300.PROMOTES.WRN.
type: Catalysis
controller: EP300
data source: Spike
xref: 20428248
controlled: Acetylation.P.EP300.WRN
control type: ACTIVATION

.SIRT1.PROMOTES.XRCC6.
type: Catalysis
controller: SIRT1
data source: Spike
xref: 17334224
controlled: Deacetylation.P.SIRT1.XRCC6
control type: ACTIVATION

.SUV420H2.PROMOTES.Family.H4...(HIST2H4B).
type: Catalysis
controller: SUV420H2
data source: Spike
xref: 19218832
controlled: Methylation.P.SUV420H2.H4
control type: ACTIVATION

.EP300.PROMOTES.TP53.
type: Catalysis
controller: EP300
data source: Spike
xref: 20094059
xref: 18931695
xref: 16024799
controlled: Acetylation.P.EP300.TP53
control type: ACTIVATION

http://www.ncbi.nlm.nih.gov/#7486
type: UnificationXref
id: 7486
db: Entrez Gene

EP400
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#57634
organism: Homo sapiens

RNF20
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#56254
organism: Homo sapiens

16009723
type: PublicationXref
title: Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1
id: 16009723
db: PubMed

AURKB
type: Protein
entity reference: AURKB

12944386
type: PublicationXref
title: In vivo recruitment of XPC to UV-induced cyclobutane pyrimidine dimers by the DDB2 gene product
id: 12944386
db: PubMed

RPA1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6117
organism: Homo sapiens

.TRIM28.INHIBITS.PMAIP1.
type: TemplateReactionRegulation
control type: INHIBITION
controller: TRIM28
data source: Spike
xref: 17942393
controlled: Transcription.Regulation.I.TRIM28.PMAIP1

11099047
type: PublicationXref
title: Deacetylation of p53 modulates its effect on cell growth and apoptosis
id: 11099047
db: PubMed

.EP300.PROMOTES.TDG.
type: Catalysis
controller: EP300
data source: Spike
xref: 11864601
controlled: Acetylation.P.EP300.TDG
control type: ACTIVATION

.Complex.DDB1.2.CUL4A....PROMOTES.Family.H4...(HIST2H4B).
type: Catalysis
controller: DDB1-2-CUL4A.complex
data source: Spike
xref: 16678110
controlled: Ubiquitination.P.DDB1.2.CUL4A.H4
control type: ACTIVATION

16772382
type: PublicationXref
title: Cockayne syndrome group B protein (CSB) plays a general role in chromatin maintenance and remodeling
id: 16772382
db: PubMed

20488183
type: PublicationXref
title: Acetylation of H2AX on lysine 36 plays a key role in the DNA double-strand break repair pathway
id: 20488183
db: PubMed

http://www.ncbi.nlm.nih.gov/#9025
type: UnificationXref
id: 9025
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#165918
type: UnificationXref
id: 165918
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#2033
type: UnificationXref
id: 2033
db: Entrez Gene

.Complex.DNA.PK..XRCC6..PROMOTES.H2AFX.
type: Catalysis
controller: DNA-PK.complex
data source: Spike
xref: 20205745
xref: 15059890
controlled: Phosphorylation.P.DNA.PK.H2AFX
control type: ACTIVATION

EP300
type: Protein
entity reference: EP300

MCPH1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#79648
organism: Homo sapiens

17634560
type: PublicationXref
title: Polymorphic TP53BP1 and TP53 gene interactions associated with risk of squamous cell carcinoma of the head and neck
id: 17634560
db: PubMed

PPP1CA
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5499
organism: Homo sapiens

HMGN1_inactive
type: Protein
entity reference: HMGN1

17709392
type: PublicationXref
title: DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics
id: 17709392
db: PubMed

H4.family_inactive
type: Protein

19407812
type: PublicationXref
title: Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells
id: 19407812
db: PubMed

WRN
type: Protein
entity reference: WRN

UCHL5
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#51377
organism: Homo sapiens

Ku heterodimer (Ku-70-ku-80).complex
type: Complex
data source: Spike
name: Ku heterodimer (Ku-70-ku-80) XRCC6-XRCC5
component: XRCC6

.HMGN2.INHIBITS.Complex.SWI/SNF..SMARCA4,.SMARCC2,.SMARCB1.(PBRM1).
type: Catalysis
controller: HMGN2
data source: Spike
xref: 19524541
controlled: Other.I.HMGN2.SWI/SNF
control type: INHIBITION

WRN
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7486
organism: Homo sapiens

19015526
type: PublicationXref
title: ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage
id: 19015526
db: PubMed

CHEK2_inactive
type: Protein
entity reference: CHEK2

http://www.ncbi.nlm.nih.gov/#84444
type: UnificationXref
id: 84444
db: Entrez Gene

.PARP1.INHIBITS.KDM5B.
type: Catalysis
controller: PARP1
data source: Spike
xref: 20832725
controlled: Physical.Interaction.I.PARP1.KDM5B
control type: INHIBITION

7664335
type: PublicationXref
title: The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH
id: 7664335
db: PubMed

http://www.ncbi.nlm.nih.gov/#2648
type: UnificationXref
id: 2648
db: Entrez Gene

10096020
type: PublicationXref
title: Tip60 acetylates six lysines of a specific class in core histones in vitro
id: 10096020
db: PubMed

LIG3
type: Protein
entity reference: LIG3

17909537
type: PublicationXref
title: Histone lysine demethylases: emerging roles in development, physiology and disease
id: 17909537
db: PubMed

16616141
type: PublicationXref
title: Evidence that low doses of Taxol enhance the functional transactivatory properties of p53 on p21 waf promoter in MCF-7 breast cancer cells
id: 16616141
db: PubMed

CHEK1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1111
organism: Homo sapiens

GADD45A_RNA
type: RnaRegion
entity reference: GADD45A

INCENP
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3619
organism: Homo sapiens

H2B.family_inactive
type: Protein

.Complex.PCAF..KAT2B..PROMOTES.Family.H3...(HIST1H3F).
type: Catalysis
controller: PCAF.complex
data source: Spike
xref: 10777601
controlled: Acetylation.P.PCAF.H3
control type: ACTIVATION

17525332
type: PublicationXref
title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
id: 17525332
db: PubMed

http://www.ncbi.nlm.nih.gov/#3619
type: UnificationXref
id: 3619
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#79648
type: UnificationXref
id: 79648
db: Entrez Gene

AURKB
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#9212
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#50484
type: UnificationXref
id: 50484
db: Entrez Gene

PMAIP1
type: Protein
entity reference: PMAIP1

H1.family_inactive
type: Protein

MDC1_DNA
type: DnaRegion
entity reference: MDC1

ATR
type: Protein
entity reference: ATR

HTATIP-UBE2N.complex
type: Complex
data source: Spike
name: HTATIP(KAT5)-UBE2N(UBC13)
component: KAT5

.KAT2A.UNKNOWN.Family.H3...(HIST1H3F).
type: Catalysis
controller: KAT2A
data source: Spike
xref: 19407812
controlled: Acetylation.U.KAT2A.H3
control type: ACTIVATION_UNKMECH

TRIM28
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#10155
organism: Homo sapiens

18438399
type: PublicationXref
title: HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response
id: 18438399
db: PubMed

SENP1
type: Protein
entity reference: SENP1

20351180
type: PublicationXref
title: The SANT domain of p400 ATPase represses acetyltransferase activity and coactivator function of TIP60 in basal p21 gene expression
id: 20351180
db: PubMed

20428248
type: PublicationXref
title: Acetylation of WRN protein regulates its stability by inhibiting ubiquitination
id: 20428248
db: PubMed

.ATM.PROMOTES.BRCA1.
type: Catalysis
controller: ATM
data source: Spike
xref: 11278964
xref: 10550055
controlled: Phosphorylation.P.ATM.BRCA1
control type: ACTIVATION

http://www.ncbi.nlm.nih.gov/#3622
type: UnificationXref
id: 3622
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#29843
type: UnificationXref
id: 29843
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#6598
type: UnificationXref
id: 6598
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#6597
type: UnificationXref
id: 6597
db: Entrez Gene

.RNF2.INHIBITS.H2AFZ.
type: Catalysis
controller: RNF2
data source: Spike
xref: 17636032
controlled: Ubiquitination.I.RNF2.H2AFZ
control type: INHIBITION

19549900
type: PublicationXref
title: Microcephalin regulates BRCA2 and Rad51-associated DNA double-strand break repair
id: 19549900
db: PubMed

XRCC6_inactive
type: Protein
entity reference: XRCC6

20587414
type: PublicationXref
title: p300-mediated Acetylation of Histone H3 Lysine 56 Functions in DNA Damage Response in Mammals
id: 20587414
db: PubMed

.RPS6KA4.PROMOTES.Family.H3...(HIST1H3F).
type: Catalysis
controller: RPS6KA4
data source: Spike
xref: 12773393
controlled: Phosphorylation.P.RPS6KA4.H3
control type: ACTIVATION

http://www.ncbi.nlm.nih.gov/#7158
type: UnificationXref
id: 7158
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#7157
type: UnificationXref
id: 7157
db: Entrez Gene

16222246
type: PublicationXref
title: Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation
id: 16222246
db: PubMed

19524541
type: PublicationXref
title: HMGN proteins act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility
id: 19524541
db: PubMed

19423655
type: PublicationXref
title: Runx2 recruits p300 to mediate parathyroid hormone's effects on histone acetylation and transcriptional activation of the matrix metalloproteinase-13 gene
id: 19423655
db: PubMed

.ATM.PROMOTES.H2AFX.
type: Catalysis
controller: ATM
data source: Spike
xref: 18285803
xref: 16531125
controlled: Phosphorylation.P.ATM.H2AFX
control type: ACTIVATION

http://www.ncbi.nlm.nih.gov/#9947
type: UnificationXref
id: 9947
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#9112
type: UnificationXref
id: 9112
db: Entrez Gene

19440044
type: PublicationXref
title: ATR kinase as master regulator of nucleotide excision repair during S phase of the cell cycle
id: 19440044
db: PubMed

Actin.family
type: Protein
data source: Spike
xref: ELK:F.000030

18381204
type: PublicationXref
title: KAP1 regulates type I interferon/STAT1-mediated IRF-1 gene expression
id: 18381204
db: PubMed

STAT1_inactive
type: Protein
entity reference: STAT1

.Complex.Gamma.H2AX...MDC1..H2AFX,.MDC1..PROMOTES.RNF8.
type: Catalysis
controller: Gamma H2AX - MDC1.complex
data source: Spike
xref: 18001824
controlled: Physical.Interaction.P.Gamma.H2AX...MDC1.RNF8
control type: ACTIVATION

19270680
type: PublicationXref
title: CBP/p300-mediated acetylation of histone H3 on lysine 56
id: 19270680
db: PubMed

.EP300.PROMOTES.H2AFX.
type: Catalysis
controller: EP300
data source: Spike
xref: 20488183
controlled: Acetylation.P.EP300.H2AFX
control type: ACTIVATION

GADD45A_DNA
type: DnaRegion
entity reference: GADD45A

ADRM1
type: Protein
entity reference: ADRM1

ATR
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#545
organism: Homo sapiens

ING2
type: Protein
entity reference: ING2

18166648
type: PublicationXref
title: The histone methyltransferase SET8 is required for S-phase progression
id: 18166648
db: PubMed

CBX1
type: Protein
entity reference: CBX1

BAX
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#581
organism: Homo sapiens

.TRIM28.INHIBITS.BBC3.
type: TemplateReactionRegulation
control type: INHIBITION
controller: TRIM28
data source: Spike
xref: 17942393
controlled: Transcription.Regulation.I.TRIM28.BBC3

18931695
type: PublicationXref
title: Regulation of apoptosis by PML and the PML-NBs
id: 18931695
db: PubMed

19158375
type: PublicationXref
title: Role of the tumor suppressor PTEN in antioxidant responsive element-mediated transcription and associated histone modifications
id: 19158375
db: PubMed

http://www.ncbi.nlm.nih.gov/#5499
type: UnificationXref
id: 5499
db: Entrez Gene

18066086
type: PublicationXref
title: Activation and regulation of ATM kinase activity in response to DNA double-strand breaks
id: 18066086
db: PubMed

KDM5B
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#10765
organism: Homo sapiens

H2AFZ
type: Protein
entity reference: H2AFZ

20424263
type: PublicationXref
title: SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1
id: 20424263
db: PubMed

16729963
type: PublicationXref
title: Phosphorylation of human high mobility group N1 protein by protein kinase CK2
id: 16729963
db: PubMed

http://www.ncbi.nlm.nih.gov/#11200
type: UnificationXref
id: 11200
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#2074
type: UnificationXref
id: 2074
db: Entrez Gene

NAP1L1
type: Protein
entity reference: NAP1L1

ERCC6
type: Protein
entity reference: ERCC6

http://www.ncbi.nlm.nih.gov/#10155
type: UnificationXref
id: 10155
db: Entrez Gene

ATM
type: Protein
entity reference: ATM

14627995
type: PublicationXref
title: Gadd45a contributes to p53 stabilization in response to DNA damage
id: 14627995
db: PubMed

KAT5
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#10524
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#10765
type: UnificationXref
id: 10765
db: Entrez Gene

CBX1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#10951
organism: Homo sapiens

PCNA
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5111
organism: Homo sapiens

Mi-2/NuRD.complex
type: Complex
data source: Spike
name: Mi2-NuRD
component: CHD3
component: HDAC1
component: MTA2
component: CHD4
component: MTA1

http://www.ncbi.nlm.nih.gov/#57634
type: UnificationXref
id: 57634
db: Entrez Gene

.RPS6KA4.PROMOTES.HMGN1.
type: Catalysis
controller: RPS6KA4
data source: Spike
xref: 12773393
controlled: Phosphorylation.P.RPS6KA4.HMGN1
control type: ACTIVATION

MDC1_RNA
type: RnaRegion
entity reference: MDC1

.Complex.NuA4..KAT5,.EP400..PROMOTES.H2AFX.
type: Catalysis
controller: NuA4.complex
data source: Spike
xref: 16904321
controlled: Acetylation.P.NuA4.H2AFX
control type: ACTIVATION

.ATM.PROMOTES.EP300.
type: Catalysis
controller: ATM
data source: Spike
xref: 20471956
controlled: Phosphorylation.P.ATM.EP300
control type: ACTIVATION

NBN
type: Protein
entity reference: NBN

Translation
type: MolecularInteraction
participant: GADD45A
participant: GADD45A_RNA

.PARP1.PROMOTES.Family.H2B...(HIST1H2BJ).
type: Catalysis
controller: PARP1
data source: Spike
xref: 1429884
controlled: Other.P.PARP1.H2B
control type: ACTIVATION

19805520
type: PublicationXref
title: Human SNF5/INI1, a component of the human SWI/SNF chromatin remodeling complex, promotes nucleotide excision repair by influencing ATM recruitment and downstream H2AX phosphorylation
id: 19805520
db: PubMed

ASF1B
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#55723
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#10951
type: UnificationXref
id: 10951
db: Entrez Gene

INO80.complex
type: Complex
data source: Spike
name: INO80
component: YY1
component: UCHL5

.PPP1CA.PROMOTES.TRIM28.
type: Catalysis
controller: PPP1CA
data source: Spike
xref: 20424263
controlled: Dephosphorylation.P.PPP1CA.TRIM28
control type: ACTIVATION

.UBE2I.PROMOTES.TRIM28.
type: Catalysis
controller: UBE2I
data source: Spike
xref: 18082607
controlled: Sumoylation.P.UBE2I.TRIM28
control type: ACTIVATION

http://www.ncbi.nlm.nih.gov/#672
type: UnificationXref
id: 672
db: Entrez Gene

H3-H4.complex
type: Complex
data source: Spike
name: H3-H4
component: H4.family
component: H3.family

http://www.ncbi.nlm.nih.gov/#675
type: UnificationXref
id: 675
db: Entrez Gene

15279789
type: PublicationXref
title: Chk1 in the DNA damage response: conserved roles from yeasts to mammals
id: 15279789
db: PubMed

TP53_inactive
type: Protein
entity reference: TP53

PMAIP1_RNA
type: RnaRegion
entity reference: PMAIP1

http://www.ncbi.nlm.nih.gov/#9810
type: UnificationXref
id: 9810
db: Entrez Gene

.KAT2B.PROMOTES.Family.H3...(HIST1H3F).
type: Catalysis
controller: KAT2B
data source: Spike
xref: 16096646
controlled: Acetylation.P.KAT2B.H3
control type: ACTIVATION

PhysicalInteraction [BRCA1 -- ZNF350 ]
type: MolecularInteraction
participant: ZNF350
participant: BRCA1
xref: 16713569
xref: 14519192
xref: 11090615

Homo sapiens
type: BioSource
xref: 9606

16782091
type: PublicationXref
title: Leucine zipper-like domain is required for tumor suppressor ING2-mediated nucleotide excision repair and apoptosis
id: 16782091
db: PubMed

RNF20
type: Protein
entity reference: RNF20

BRCA1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#672
organism: Homo sapiens

HP1-BETA-H3K9me.complex_inactive
type: Protein

15469825
type: PublicationXref
title: Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin
id: 15469825
db: PubMed

11336697
type: PublicationXref
title: Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins
id: 11336697
db: PubMed

AURKB_inactive
type: Protein
entity reference: AURKB

16360315
type: PublicationXref
title: Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response
id: 16360315
db: PubMed

.EP300.PROMOTES.PARP1.
type: Catalysis
controller: EP300
data source: Spike
xref: 16204234
controlled: Acetylation.P.EP300.PARP1
control type: ACTIVATION

http://www.ncbi.nlm.nih.gov/#1643
type: UnificationXref
id: 1643
db: Entrez Gene

11252893
type: PublicationXref
title: The many substrates and functions of ATM
id: 11252893
db: PubMed

HP1.family
type: Protein
member physical entity: CBX1
data source: Spike
xref: TAU:F.000007

ASF1A
type: Protein
entity reference: ASF1A

19221478
type: PublicationXref
title: Cockayne syndrome B protein (CSB): linking p53, HIF-1 and p300 to robustness, lifespan, cancer and cell fate decisions
id: 19221478
db: PubMed

HMGN1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3150
organism: Homo sapiens

UBE2I
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7329
organism: Homo sapiens

20205745
type: PublicationXref
title: DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression
id: 20205745
db: PubMed

ERCC6_inactive
type: Protein
entity reference: ERCC6

17145710
type: PublicationXref
title: IntAct--open source resource for molecular interaction data
id: 17145710
db: PubMed

http://www.ncbi.nlm.nih.gov/#51377
type: UnificationXref
id: 51377
db: Entrez Gene

APEX1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#328
organism: Homo sapiens

17137291
type: PublicationXref
title: Physical interaction of two cancer-testis antigens, MAGE-C1 (CT7) and NY-ESO-1 (CT6)
id: 17137291
db: PubMed

KAT5_inactive
type: Protein
entity reference: KAT5

http://www.ncbi.nlm.nih.gov/#9869
type: UnificationXref
id: 9869
db: Entrez Gene

BAX_RNA
type: RnaRegion
entity reference: BAX

9733515
type: PublicationXref
title: Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
id: 9733515
db: PubMed

http://www.ncbi.nlm.nih.gov/#6772
type: UnificationXref
id: 6772
db: Entrez Gene

9733514
type: PublicationXref
title: Enhanced phosphorylation of p53 by ATM in response to DNA damage
id: 9733514
db: PubMed

RPS6KA4
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8986
organism: Homo sapiens

ATM
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#472
organism: Homo sapiens

12574133
type: PublicationXref
title: p53 is a chromatin accessibility factor for nucleotide excision repair of DNA damage
id: 12574133
db: PubMed

MTA1
type: Protein
entity reference: MTA1

HMGN1
type: Protein
entity reference: HMGN1

.Family.H3....PROMOTES.Complex.SWI/SNF..SMARCA4,.SMARCC2,.SMARCB1.(PBRM1).
type: Catalysis
controller: H3.family
data source: Spike
xref: 20224553
controlled: mRNA.stability.P.H3.SWI/SNF
control type: ACTIVATION

BRCA1_DNA
type: DnaRegion
entity reference: BRCA1

http://www.ncbi.nlm.nih.gov/#328
type: UnificationXref
id: 328
db: Entrez Gene

.TP53.PROMOTES.RRM2B.
type: TemplateReactionRegulation
control type: ACTIVATION
controller: TP53
data source: Spike
xref: 12565178
controlled: Transcription.Regulation.P.TP53.RRM2B

.NAP1L1.PROMOTES.Complex.H2A.H2B..Family.H2A..H2AFX,.H2AFZ.,.Family.H2B....(HIST1H2BJ).
type: Catalysis
controller: NAP1L1
data source: Spike
xref: 20002496
controlled: Physical.Interaction.P.NAP1L1.H2A.H2B
control type: ACTIVATION

10753971
type: PublicationXref
title: Acetylation of novel sites in the nucleosomal binding domain of chromosomal protein HMG-14 by p300 alters its interaction with nucleosomes
id: 10753971
db: PubMed

MYST1
type: Protein
entity reference: MYST1

.SIRT1.INHIBITS.WRN.
type: Catalysis
controller: SIRT1
data source: Spike
xref: 20428248
controlled: Deacetylation.I.SIRT1.WRN
control type: INHIBITION

http://www.ncbi.nlm.nih.gov/#10524
type: UnificationXref
id: 10524
db: Entrez Gene

.SUV39H1.INHIBITS.Family.H3...(HIST1H3F).
type: Catalysis
controller: SUV39H1
data source: Spike
xref: 19442252
controlled: Methylation.I.SUV39H1.H3
control type: INHIBITION

.Complex.MRN..NBN..PROMOTES.ATM.
type: Catalysis
controller: MRN.complex
data source: Spike
xref: 18285803
xref: 18066086
controlled: Physical.Interaction.P.MRN.ATM
control type: ACTIVATION

.EP400.INHIBITS.KAT5.
type: Catalysis
controller: EP400
data source: Spike
xref: 20351180
controlled: Physical.Interaction.I.EP400.KAT5
control type: INHIBITION

15272308
type: PublicationXref
title: Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism
id: 15272308
db: PubMed

CHEK1
type: Protein
entity reference: CHEK1

Nucleosome.complex_inactive
type: Protein

19442252
type: PublicationXref
title: The impact of heterochromatin on DSB repair
id: 19442252
db: PubMed

CHEK2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#11200
organism: Homo sapiens

TDG
type: Protein
entity reference: TDG

KDM5B_inactive
type: Protein
entity reference: KDM5B

RRM2B
type: Protein
entity reference: RRM2B

PhysicalInteraction [Family H1 {} -- Family HP1 {CBX1} ]
type: MolecularInteraction
participant: H1.family
participant: HP1.family
xref: 11336697

http://www.ncbi.nlm.nih.gov/#7528
type: UnificationXref
id: 7528
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#545
type: UnificationXref
id: 545
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#9656
type: UnificationXref
id: 9656
db: Entrez Gene

CDKN1A_RNA
type: RnaRegion
entity reference: CDKN1A

MRN.complex
type: Complex
data source: Spike
name: MRE11-RAD50-NBS1
component: NBN

CREBBP
type: Protein
entity reference: CREBBP

NAP1L1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4673
organism: Homo sapiens

PARP1_inactive
type: Protein
entity reference: PARP1

SUV420H1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#51111
organism: Homo sapiens

ATR-ATRIP.complex_inactive
type: Protein

PhysicalInteraction [SMARCA4 -- XPC ]
type: MolecularInteraction
participant: SMARCA4
participant: XPC
xref: 19740755

XRCC6
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2547
organism: Homo sapiens

TP53
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7157
organism: Homo sapiens

.Complex.CK2....PROMOTES.RPS6KA4.
type: Catalysis
controller: CK2.complex
data source: Spike
xref: 19933278
controlled: Phosphorylation.P.CK2.RPS6KA4
control type: ACTIVATION

.PCNA.PROMOTES.Complex.CAF.1...(CHAF1B).
type: Catalysis
controller: PCNA
data source: Spike
xref: 10648606
xref: 20112283
controlled: Physical.Interaction.P.PCNA.CAF.1
control type: ACTIVATION

11897662
type: PublicationXref
title: Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway
id: 11897662
db: PubMed

18022353
type: PublicationXref
title: New nomenclature for chromatin-modifying enzymes
id: 18022353
db: PubMed

TP53BP1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7158
organism: Homo sapiens

.KAT5.PROMOTES.Family.H3...(HIST1H3F).
type: Catalysis
controller: KAT5
data source: Spike
xref: 10096020
controlled: Acetylation.P.KAT5.H3
control type: ACTIVATION

TFIIH.complex
type: Complex
data source: Spike
name: TFIIH [nucleoplasm]

17599047
type: PublicationXref
title: Distinct BRCT domains in Mcph1/Brit1 mediate ionizing radiation-induced focus formation and centrosomal localization
id: 17599047
db: PubMed

.Complex.Gamma.H2AX...MDC1..H2AFX,.MDC1..PROMOTES.NBN.
type: Catalysis
controller: Gamma H2AX - MDC1.complex
data source: Spike
xref: 17963495
controlled: Physical.Interaction.P.Gamma.H2AX...MDC1.NBN
control type: ACTIVATION

.ASF1A.PROMOTES.Complex.CAF.1...(CHAF1B).
type: Catalysis
controller: ASF1A
data source: Spike
xref: 11897662
controlled: Physical.Interaction.P.ASF1A.CAF.1
control type: ACTIVATION

CK2.complex
type: Complex
data source: Spike
name: Caseine Kinase 2

http://www.ncbi.nlm.nih.gov/#4673
type: UnificationXref
id: 4673
db: Entrez Gene

20112283
type: PublicationXref
title: Histone modifications: crucial elements for damage response and chromatin restoration
id: 20112283
db: PubMed

NBN
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4683
organism: Homo sapiens

12234980
type: PublicationXref
title: Increased mitotic phosphorylation of histone H3 attributable to AIM-1/Aurora-B overexpression contributes to chromosome number instability
id: 12234980
db: PubMed

18922472
type: PublicationXref
title: Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex
id: 18922472
db: PubMed

http://www.ncbi.nlm.nih.gov/#5366
type: UnificationXref
id: 5366
db: Entrez Gene

H2B.family
type: Protein
data source: Spike
xref: ELK:F.000027

11864601
type: PublicationXref
title: Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription
id: 11864601
db: PubMed

PhysicalInteraction [SMARCB1 -- XPC ]
type: MolecularInteraction
participant: SMARCB1
participant: XPC
xref: 19805520

Spike
type: Provenance

.SMARCA4.PROMOTES.CDKN1A.
type: TemplateReactionRegulation
control type: ACTIVATION
controller: SMARCA4
data source: Spike
xref: 18414052
controlled: Transcription.Regulation.P.SMARCA4.CDKN1A

17923702
type: PublicationXref
title: DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity
id: 17923702
db: PubMed

http://www.ncbi.nlm.nih.gov/#6117
type: UnificationXref
id: 6117
db: Entrez Gene

APEX1_inactive
type: Protein
entity reference: APEX1

http://www.ncbi.nlm.nih.gov/#25842
type: UnificationXref
id: 25842
db: Entrez Gene

DOT1L
type: Protein
entity reference: DOT1L

16096646
type: PublicationXref
title: Chromosomal protein HMGN1 enhances the acetylation of lysine 14 in histone H3
id: 16096646
db: PubMed

17334224
type: PublicationXref
title: SIRT1 promotes DNA repair activity and deacetylation of Ku70
id: 17334224
db: PubMed

20385750
type: PublicationXref
title: Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer
id: 20385750
db: PubMed

.ATM.PROMOTES.RRM2B.
type: Catalysis
controller: ATM
data source: Spike
xref: 19015526
controlled: Phosphorylation.P.ATM.RRM2B
control type: ACTIVATION

H2AFX
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3014
organism: Homo sapiens

.Complex.INO80..YY1,.UCHL5..PROMOTES.Complex.Nucleosome..Family.H2A..H2AFX,.H2AFZ.,.Family.H2B...,.Family.H3...,.Family.H4...,.Family.H1....(HIST2H4B).
type: Catalysis
controller: INO80.complex
data source: Spike
xref: 19424290
controlled: Other.P.INO80.Nucleosome
control type: ACTIVATION

http://www.ncbi.nlm.nih.gov/#7508
type: UnificationXref
id: 7508
db: Entrez Gene

15743907
type: PublicationXref
title: ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation
id: 15743907
db: PubMed

ERCC8
type: Protein
entity reference: ERCC8

9774970
type: PublicationXref
title: Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells
id: 9774970
db: PubMed

PPP1CA
type: Protein
entity reference: PPP1CA

ASF1B
type: Protein
entity reference: ASF1B

TDG
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6996
organism: Homo sapiens

16647857
type: PublicationXref
title: Ubiquitin and SUMO systems in the regulation of mitotic checkpoints
id: 16647857
db: PubMed

YY1
type: Protein
entity reference: YY1

DDB1-2 (XPE).complex
type: Complex
data source: Spike
name: xeroderma pigmentosum complementation group E

MAGEC1
type: Protein
entity reference: MAGEC1

H2AFZ
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3015
organism: Homo sapiens

16678110
type: PublicationXref
title: Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage
id: 16678110
db: PubMed

UBE2I
type: Protein
entity reference: UBE2I

H3.family
type: Protein
data source: Spike
xref: ELK:F.000028

11425514
type: PublicationXref
title: The p48 subunit of the damaged-DNA binding protein DDB associates with the CBP/p300 family of histone acetyltransferase
id: 11425514
db: PubMed

20832725
type: PublicationXref
title: PARP-1 Regulates Chromatin Structure and Transcription through a KDM5B-Dependent Pathway
id: 20832725
db: PubMed

17272272
type: PublicationXref
title: Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double strand breaks
id: 17272272
db: PubMed

.ATM.PROMOTES.TP53.
type: Catalysis
controller: ATM
data source: Spike
xref: 9733515
xref: 9733514
xref: 9843217
controlled: Phosphorylation.P.ATM.TP53
control type: ACTIVATION

.Complex.DDB1.CUL4A....PROMOTES.Family.H2A..H2AFX,.H2AFZ.(H2AFZ).
type: Catalysis
controller: DDB1-CUL4A.complex
data source: Spike
xref: 16940174
controlled: Ubiquitination.P.DDB1.CUL4A.H2A
control type: ACTIVATION

18614047
type: PublicationXref
title: H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation
id: 18614047
db: PubMed

http://www.ncbi.nlm.nih.gov/#472
type: UnificationXref
id: 472
db: Entrez Gene

.ERCC6.PROMOTES.Complex.Nucleosome..Family.H2A..H2AFX,.H2AFZ.,.Family.H2B...,.Family.H3...,.Family.H4...,.Family.H1....(HIST2H4B).
type: Catalysis
controller: ERCC6
data source: Spike
xref: 16772382
controlled: mRNA.stability.P.ERCC6.Nucleosome
control type: ACTIVATION

17942393
type: PublicationXref
title: Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression
id: 17942393
db: PubMed

SIRT1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#23411
organism: Homo sapiens

CAF-1.complex
type: Complex
data source: Spike
name: chromatin assembly factor 1

16204234
type: PublicationXref
title: Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription
id: 16204234
db: PubMed

DDB2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1643
organism: Homo sapiens

DNA-PK.complex
type: Complex
data source: Spike
name: DNA-PK
component: XRCC6

http://www.ncbi.nlm.nih.gov/#1647
type: UnificationXref
id: 1647
db: Entrez Gene

.TP53.PROMOTES.GADD45A.
type: TemplateReactionRegulation
control type: ACTIVATION
controller: TP53
data source: Spike
xref: 16990795
xref: 14627995
xref: 15603758
controlled: Transcription.Regulation.P.TP53.GADD45A

SENP1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#29843
organism: Homo sapiens

12773393
type: PublicationXref
title: MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14
id: 12773393
db: PubMed

ssDNA-RPA.complex
type: Complex
data source: Spike
name: single stranded DNA
component: RPA1

ADRM1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#11047
organism: Homo sapiens

Gamma H2AX - MDC1.complex
type: Complex
data source: Spike
name: Gamma H2AX - MDC1
component: MDC1
component: H2AFX

CHD4
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1108
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#581
type: UnificationXref
id: 581
db: Entrez Gene

RNF168
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#165918
organism: Homo sapiens

.ATM.PROMOTES.CHEK2.
type: Catalysis
controller: ATM
data source: Spike
xref: 12773400
xref: 9889122
controlled: Phosphorylation.P.ATM.CHEK2
control type: ACTIVATION

PhysicalInteraction [PCNA -- SETD8 ]
type: MolecularInteraction
participant: SETD8
participant: PCNA
xref: 18319261

PMAIP1_DNA
type: DnaRegion
entity reference: PMAIP1

PhysicalInteraction [TP53 -- TP53BP1 ]
type: MolecularInteraction
participant: TP53BP1
participant: TP53
xref: 16713569
xref: 17634560

17963495
type: PublicationXref
title: Extensive ssDNA end formation at DNA double-strand breaks in non-homologous end-joining deficient cells during the S phase
id: 17963495
db: PubMed

SUV420H2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#84787
organism: Homo sapiens

.KAT5.PROMOTES.Family.H4...(HIST2H4B).
type: Catalysis
controller: KAT5
data source: Spike
xref: 10096020
controlled: Acetylation.P.KAT5.H4
control type: ACTIVATION

.PARP1.PROMOTES.Family.H4...(HIST2H4B).
type: Catalysis
controller: PARP1
data source: Spike
xref: 1429884
controlled: Other.P.PARP1.H4
control type: ACTIVATION

.ADRM1.PROMOTES.UCHL5.
type: Catalysis
controller: ADRM1
data source: Spike
xref: 18922472
controlled: Physical.Interaction.P.ADRM1.UCHL5
control type: ACTIVATION

20032463
type: PublicationXref
title: Histone deacetylase 10 relieves repression on the melanogenic program by maintaining the deacetylation status of repressors
id: 20032463
db: PubMed

http://www.ncbi.nlm.nih.gov/#4683
type: UnificationXref
id: 4683
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#2547
type: UnificationXref
id: 2547
db: Entrez Gene

H3.family_inactive
type: Protein

MAGEC1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#9947
organism: Homo sapiens

XPC_inactive
type: Protein
entity reference: XPC

RPA1
type: Protein
entity reference: RPA1

.EP300.PROMOTES.NBN.
type: Catalysis
controller: EP300
data source: Spike
xref: 20471956
controlled: Other.P.EP300.NBN
control type: ACTIVATION

UCHL5
type: Protein
entity reference: UCHL5

19740755
type: PublicationXref
title: Modulation of nucleotide excision repair by mammalian SWI/SNF chromatin-remodeling complex
id: 19740755
db: PubMed

20224553
type: PublicationXref
title: A cooperative activation loop among SWI/SNF, gamma-H2AX and H3 acetylation for DNA double-strand break repair
id: 20224553
db: PubMed

19444312
type: PublicationXref
title: Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells
id: 19444312
db: PubMed

ZNF350
type: Protein
entity reference: ZNF350

.HDAC1.INHIBITS.TP53.
type: Catalysis
controller: HDAC1
data source: Spike
xref: 12426395
xref: 11099047
controlled: Deacetylation.I.HDAC1.TP53
control type: INHIBITION

SUV39H1
type: Protein
entity reference: SUV39H1

9889122
type: PublicationXref
title: A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
id: 9889122
db: PubMed

NuA4.complex
type: Complex
data source: Spike
name: NuA4/Tip60 HAT complex
component: KAT5
component: EP400

CREBBP
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1387
organism: Homo sapiens

.ERCC6.INHIBITS.TP53.
type: Catalysis
controller: ERCC6
data source: Spike
xref: 19221478
xref: 18784753
controlled: Physical.Interaction.I.ERCC6.TP53
control type: INHIBITION

SMARCB1
type: Protein
entity reference: SMARCB1

MDC1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#9656
organism: Homo sapiens

HDAC1
type: Protein
entity reference: HDAC1

BRCA1
type: Protein
entity reference: BRCA1

KAT5
type: Protein
entity reference: KAT5

YY1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7528
organism: Homo sapiens

CDKN1A_DNA
type: DnaRegion
entity reference: CDKN1A

19933278
type: PublicationXref
title: Differential regulation of mitogen- and stress-activated protein kinase-1 and -2 (MSK1 and MSK2) by CK2 following UV radiation
id: 19933278
db: PubMed

H3-H4.complex_inactive
type: Protein

18285803
type: PublicationXref
title: Regulation of DNA repair throughout the cell cycle
id: 18285803
db: PubMed

H2A.family
type: Protein
member physical entity: H2AFZ
member physical entity: H2AFX
data source: Spike
xref: ELK:F.000026

SUV420H1
type: Protein
entity reference: SUV420H1

H2AFX_inactive
type: Protein
entity reference: H2AFX

TP53
type: Protein
entity reference: TP53

15603758
type: PublicationXref
title: Gadd45a, a p53- and BRCA1-regulated stress protein, in cellular response to DNA damage
id: 15603758
db: PubMed

.ATR.PROMOTES.CHEK1.
type: Catalysis
controller: ATR
data source: Spike
xref: 16431910
xref: 15279789
xref: 12766152
xref: 12781359
xref: 15190204
xref: 15272308
xref: 10859164
xref: 10859163
xref: 16360315
xref: 11090622
xref: 11390642
controlled: Phosphorylation.P.ATR.CHEK1
control type: ACTIVATION

ELK:F.000030
type: UnificationXref
id: ELK:F-000030
db: Spike DB

15059890
type: PublicationXref
title: ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation
id: 15059890
db: PubMed

http://www.ncbi.nlm.nih.gov/#6601
type: UnificationXref
id: 6601
db: Entrez Gene

.Complex.SWI/SNF..SMARCA4,.SMARCC2,.SMARCB1..PROMOTES.GADD45A.
type: TemplateReactionRegulation
control type: ACTIVATION
controller: SWI/SNF.complex
data source: Spike
xref: 18414052
controlled: Transcription.Regulation.P.SWI/SNF.GADD45A

.STAT1.PROMOTES.MDC1.
type: TemplateReactionRegulation
control type: ACTIVATION
controller: STAT1
data source: Spike
xref: 15784679
controlled: Transcription.Regulation.P.STAT1.MDC1

RNF40
type: Protein
entity reference: RNF40

.EP300.PROMOTES.Family.H3...(HIST1H3F).
type: Catalysis
controller: EP300
data source: Spike
xref: 19158375
xref: 19270680
xref: 20587414
controlled: Acetylation.P.EP300.H3
control type: ACTIVATION

.RNF8.PROMOTES.RNF168.
type: Catalysis
controller: RNF8
data source: Spike
xref: 20385750
controlled: Other.P.RNF8.RNF168
control type: ACTIVATION

ELK:F.000026
type: UnificationXref
id: ELK:F-000026
db: Spike DB

12154074
type: PublicationXref
title: Cell differentiation induces TIF1beta association with centromeric heterochromatin via an HP1 interaction
id: 12154074
db: PubMed

.TRIM28.INHIBITS.CDKN1A.
type: TemplateReactionRegulation
control type: INHIBITION
controller: TRIM28
data source: Spike
xref: 17942393
controlled: Transcription.Regulation.I.TRIM28.CDKN1A

ELK:F.000028
type: UnificationXref
id: ELK:F-000028
db: Spike DB

NFkB.complex
type: Complex
data source: Spike
name: Nuclear factor kappa-B

19056256
type: PublicationXref
title: Catalysis and substrate selection by histone/protein lysine acetyltransferases
id: 19056256
db: PubMed

ELK:F.000027
type: UnificationXref
id: ELK:F-000027
db: Spike DB

H2A-H2B.complex
type: Complex
data source: Spike
name: H2A-H2B
component: H2A.family
component: H2B.family

ELK:F.000029
type: UnificationXref
id: ELK:F-000029
db: Spike DB

.TRIM28.PROMOTES.TRIM28.
type: Catalysis
controller: TRIM28
data source: Spike
xref: 18488044
controlled: Sumoylation.P.TRIM28.TRIM28
control type: ACTIVATION

.Complex.DDB1.CUL4A....PROMOTES.H2AFX.
type: Catalysis
controller: DDB1-CUL4A.complex
data source: Spike
xref: 16940174
controlled: Ubiquitination.P.DDB1.CUL4A.H2AFX
control type: ACTIVATION

PhysicalInteraction [SETDB1 -- TRIM28 ]
type: MolecularInteraction
participant: TRIM28
participant: SETDB1
xref: 11959841

11791185
type: PublicationXref
title: Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor
id: 11791185
db: PubMed

.PARP1.PROMOTES.Family.H3...(HIST1H3F).
type: Catalysis
controller: PARP1
data source: Spike
xref: 1429884
controlled: Other.P.PARP1.H3
control type: ACTIVATION

.Complex.NuA4..KAT5,.EP400..PROMOTES.ATM.
type: Catalysis
controller: NuA4.complex
data source: Spike
xref: 17923702
controlled: Acetylation.P.NuA4.ATM
control type: ACTIVATION

Translation
type: MolecularInteraction
participant: BBC3
participant: BBC3_RNA

.MDC1.PROMOTES.TP53BP1.
type: Catalysis
controller: MDC1
data source: Spike
xref: 16009723
controlled: Physical.Interaction.P.MDC1.TP53BP1
control type: ACTIVATION

.HDAC10.INHIBITS.TRIM28.
type: Catalysis
controller: HDAC10
data source: Spike
xref: 20032463
controlled: Deacetylation.I.HDAC10.TRIM28
control type: INHIBITION

http://www.ncbi.nlm.nih.gov/#8850
type: UnificationXref
id: 8850
db: Entrez Gene

.Complex.DDB1.2.(XPE)....PROMOTES.XPC.
type: Catalysis
controller: DDB1-2 (XPE).complex
data source: Spike
xref: 12944386
controlled: Physical.Interaction.P.DDB1.2.(XPE).XPC
control type: ACTIVATION

DOT1L
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#84444
organism: Homo sapiens

ASF1A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#25842
organism: Homo sapiens

12123582
type: PublicationXref
title: Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain
id: 12123582
db: PubMed

CHD3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1107
organism: Homo sapiens

19424290
type: PublicationXref
title: Chromatin remodelling beyond transcription: the INO80 and SWR1 complexes
id: 19424290
db: PubMed

http://www.ncbi.nlm.nih.gov/#27113
type: UnificationXref
id: 27113
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#11047
type: UnificationXref
id: 11047
db: Entrez Gene

CHD3
type: Protein
entity reference: CHD3

.TP53.PROMOTES.EP300.
type: Catalysis
controller: TP53
data source: Spike
xref: 12574133
controlled: Physical.Interaction.P.TP53.EP300
control type: ACTIVATION

SMARCA4
type: Protein
entity reference: SMARCA4

APEX1
type: Protein
entity reference: APEX1

CHD4_inactive
type: Protein
entity reference: CHD4

16940174
type: PublicationXref
title: DDB1 maintains genome integrity through regulation of Cdt1
id: 16940174
db: PubMed

H1.family
type: Protein
data source: Spike
xref: CEN:F.329895

H2A.family_inactive
type: Protein

RNF40
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#9810
organism: Homo sapiens

SMARCB1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6598
organism: Homo sapiens

16713569
type: PublicationXref
title: A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
id: 16713569
db: PubMed

.KDM5B.INHIBITS.Family.H3...(HIST1H3F).
type: Catalysis
controller: KDM5B
data source: Spike
xref: 17909537
controlled: Demethylation.I.KDM5B.H3
control type: INHIBITION

.Complex.HTATIP.UBE2N..KAT5..PROMOTES.H2AFX.
type: Catalysis
controller: HTATIP-UBE2N.complex
data source: Spike
xref: 17709392
controlled: Acetylation.P.HTATIP.UBE2N.H2AFX
control type: ACTIVATION

10777601
type: PublicationXref
title: The accessibility of histone H3 tails in chromatin modulates their acetylation by P300/CBP-associated factor
id: 10777601
db: PubMed

18319261
type: PublicationXref
title: Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication
id: 18319261
db: PubMed

SMARCC2_inactive
type: Protein
entity reference: SMARCC2

MTA2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#9219
organism: Homo sapiens

11390642
type: PublicationXref
title: ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
id: 11390642
db: PubMed

HP1-BETA-H3K9me.complex
type: Complex
data source: Spike
name: HP1-BETA (CBX1)-H3K9me
component: H3.family
component: CBX1

18414052
type: PublicationXref
title: Role of the mammalian SWI/SNF chromatin remodeling complex in the cellular response to UV damage
id: 18414052
db: PubMed

.NAP1L1.INHIBITS.Complex.H2A.H2B..Family.H2A..H2AFX,.H2AFZ.,.Family.H2B....(HIST1H2BJ).
type: Catalysis
controller: NAP1L1
data source: Spike
xref: 20002496
controlled: Physical.Interaction.I.NAP1L1.H2A.H2B
control type: INHIBITION

18488044
type: PublicationXref
title: Structural insights into human KAP1 PHD finger-bromodomain and its role in gene silencing
id: 18488044
db: PubMed

BRCA2
type: Protein
entity reference: BRCA2

http://www.ncbi.nlm.nih.gov/#142
type: UnificationXref
id: 142
db: Entrez Gene

.Complex.SRCAP.(SWR.C)..H2AFZ..PROMOTES.H2AFZ.
type: Catalysis
controller: SRCAP-(SWR-C).complex
data source: Spike
xref: 16634648
controlled: Physical.Interaction.P.SRCAP.(SWR.C).H2AFZ
control type: ACTIVATION

16024812
type: PublicationXref
title: hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells
id: 16024812
db: PubMed

.Family.H3....PROMOTES.TP53BP1.
type: Catalysis
controller: H3.family
data source: Spike
xref: 16774833
controlled: Physical.Interaction.P.H3.TP53BP1
control type: ACTIVATION

CHD4
type: Protein
entity reference: CHD4

19525936
type: PublicationXref
title: BRIT1/MCPH1 links chromatin remodelling to DNA damage response
id: 19525936
db: PubMed

.MYST1.PROMOTES.Family.H4...(HIST2H4B).
type: Catalysis
controller: MYST1
data source: Spike
xref: 19056256
xref: 16024812
xref: 15923642
xref: 20479123
controlled: Acetylation.P.MYST1.H4
control type: ACTIVATION

12773400
type: PublicationXref
title: A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein
id: 12773400
db: PubMed

.SUV420H1.PROMOTES.Family.H4...(HIST2H4B).
type: Catalysis
controller: SUV420H1
data source: Spike
xref: 19218832
controlled: Methylation.P.SUV420H1.H4
control type: ACTIVATION

12919958
type: PublicationXref
title: ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses
id: 12919958
db: PubMed

Translation
type: MolecularInteraction
participant: CDKN1A
participant: CDKN1A_RNA

BRCA2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#675
organism: Homo sapiens

18443409
type: PublicationXref
title: New players in the BRCA1-mediated DNA damage responsive pathway
id: 18443409
db: PubMed

.ATM.PROMOTES.SMARCC2.
type: Catalysis
controller: ATM
data source: Spike
xref: 19525936
controlled: Phosphorylation.P.ATM.SMARCC2
control type: ACTIVATION

19218832
type: PublicationXref
title: Chromatin dynamics coupled to DNA repair
id: 19218832
db: PubMed

MCPH1
type: Protein
entity reference: MCPH1

Translation
type: MolecularInteraction
participant: RRM2B_inactive
participant: RRM2B_RNA

TP53BP1_inactive
type: Protein
entity reference: TP53BP1

Nucleosome.complex
type: Complex
data source: Spike
name: Nucleosome
component: H2A.family
component: H1.family
component: H4.family
component: H3.family
component: H2B.family

BAX
type: Protein
entity reference: BAX

SUV420H2
type: Protein
entity reference: SUV420H2

TAU:F.000007
type: UnificationXref
id: TAU:F-000007
db: Spike DB

ING2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3622
organism: Homo sapiens

.Complex.CAF.1....PROMOTES.Complex.H3.H4..Family.H4...,.Family.H3....(HIST2H4B).
type: Catalysis
controller: CAF-1.complex
data source: Spike
xref: 20112283
controlled: Other.P.CAF.1.H3.H4
control type: ACTIVATION

CSA-DDB1-CUL4A.complex
type: Complex
data source: Spike
name: CSA-DDB1-CUL4A
component: ERCC8

20471956
type: PublicationXref
title: Phosphorylation of p300 by ATM controls the stability of NBS1
id: 20471956
db: PubMed

RRM2B_RNA
type: RnaRegion
entity reference: RRM2B

http://www.ncbi.nlm.nih.gov/#6839
type: UnificationXref
id: 6839
db: Entrez Gene

SMARCC2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6601
organism: Homo sapiens

HMGN2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3151
organism: Homo sapiens

KAT2B
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8850
organism: Homo sapiens

20479123
type: PublicationXref
title: MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair
id: 20479123
db: PubMed

TRIM28_inactive
type: Protein
entity reference: TRIM28

http://www.ncbi.nlm.nih.gov/#8986
type: UnificationXref
id: 8986
db: Entrez Gene

XPC
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7508
organism: Homo sapiens

ATM_inactive
type: Protein
entity reference: ATM

17291544
type: PublicationXref
title: ATP-dependent chromatin remodeling factors and DNA damage repair
id: 17291544
db: PubMed

GADD45A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1647
organism: Homo sapiens

PhysicalInteraction [H2AFZ -- INCENP ]
type: MolecularInteraction
participant: H2AFZ
participant: INCENP
xref: 12660166

CDKN1A
type: Protein
entity reference: CDKN1A

HDAC1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3065
organism: Homo sapiens

HDAC10
type: Protein
entity reference: HDAC10

RRM2B
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#50484
organism: Homo sapiens

H2A-H2B.complex_inactive
type: Protein

.ATM.INHIBITS.TRIM28.
type: Catalysis
controller: ATM
data source: Spike
xref: 20424263
xref: 17942393
controlled: Phosphorylation.I.ATM.TRIM28
control type: INHIBITION

.SETD8.PROMOTES.Family.H4...(HIST2H4B).
type: Catalysis
controller: SETD8
data source: Spike
xref: 18166648
controlled: Methylation.P.SETD8.H4
control type: ACTIVATION

RNF2
type: Protein
entity reference: RNF2

SETDB1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#9869
organism: Homo sapiens

.Complex.CK2....PROMOTES.HMGN1.
type: Catalysis
controller: CK2.complex
data source: Spike
xref: 16729963
controlled: Phosphorylation.P.CK2.HMGN1
control type: ACTIVATION

http://www.ncbi.nlm.nih.gov/#6045
type: UnificationXref
id: 6045
db: Entrez Gene

PhysicalInteraction [BRCA1 -- BRCA2 ]
type: MolecularInteraction
participant: BRCA2
participant: BRCA1
xref: 9774970
xref: 16713569

.SENP1.INHIBITS.TRIM28.
type: Catalysis
controller: SENP1
data source: Spike
xref: 17942393
controlled: Desumoylation.I.SENP1.TRIM28
control type: INHIBITION

.ATR.PROMOTES.H2AFX.
type: Catalysis
controller: ATR
data source: Spike
xref: 12919958
controlled: Phosphorylation.P.ATR.H2AFX
control type: ACTIVATION

.Complex.SRCAP.(SWR.C)..H2AFZ..PROMOTES.Family.H2A..H2AFX,.H2AFZ.(H2AFZ).
type: Catalysis
controller: SRCAP-(SWR-C).complex
data source: Spike
xref: 19424290
controlled: Other.P.SRCAP.(SWR.C).H2A
control type: ACTIVATION

.EP300.INHIBITS.HMGN1.
type: Catalysis
controller: EP300
data source: Spike
xref: 10753971
controlled: mRNA.stability.I.EP300.HMGN1
control type: INHIBITION

.RNF2.INHIBITS.Family.H2A..H2AFX,.H2AFZ.(H2AFZ).
type: Catalysis
controller: RNF2
data source: Spike
xref: 15386022
controlled: Ubiquitination.I.RNF2.H2A
control type: INHIBITION

.ZNF350.PROMOTES.TRIM28.
type: Catalysis
controller: ZNF350
data source: Spike
xref: 14519192
controlled: Physical.Interaction.P.ZNF350.TRIM28
control type: ACTIVATION

.Complex.CK2....INHIBITS.Complex.HP1.BETA.H3K9me..CBX1,.Family.H3....(CBX1).
type: Catalysis
controller: CK2.complex
data source: Spike
xref: 18438399
controlled: Phosphorylation.I.CK2.HP1.BETA.H3K9me
control type: INHIBITION

BBC3_DNA
type: DnaRegion
entity reference: BBC3

PMAIP1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5366
organism: Homo sapiens

.TDG.PROMOTES.APEX1.
type: Catalysis
controller: TDG
data source: Spike
xref: 11864601
controlled: Physical.Interaction.P.TDG.APEX1
control type: ACTIVATION

16431910
type: PublicationXref
title: Rapid activation of ATR by ionizing radiation requires ATM and Mre11
id: 16431910
db: PubMed

.RNF168.PROMOTES.H2AFX.
type: Catalysis
controller: RNF168
data source: Spike
xref: 19342239
controlled: Ubiquitination.P.RNF168.H2AFX
control type: ACTIVATION

.EP300.PROMOTES.Family.H4...(HIST2H4B).
type: Catalysis
controller: EP300
data source: Spike
xref: 19423655
controlled: Acetylation.P.EP300.H4
control type: ACTIVATION

.TRIM28.INHIBITS.BAX.
type: TemplateReactionRegulation
control type: INHIBITION
controller: TRIM28
data source: Spike
xref: 17942393
controlled: Transcription.Regulation.I.TRIM28.BAX

Translation
type: MolecularInteraction
participant: MDC1_RNA
participant: MDC1

15190204
type: PublicationXref
title: ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage
id: 15190204
db: PubMed

.CREBBP.PROMOTES.WRN.
type: Catalysis
controller: CREBBP
data source: Spike
xref: 20428248
controlled: Acetylation.P.CREBBP.WRN
control type: ACTIVATION

ERCC8
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1161
organism: Homo sapiens

CHEK1_inactive
type: Protein
entity reference: CHEK1

http://www.ncbi.nlm.nih.gov/#1111
type: UnificationXref
id: 1111
db: Entrez Gene

HDAC10
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#83933
organism: Homo sapiens

.RNF168.PROMOTES.Family.H2A..H2AFX,.H2AFZ.(H2AFX).
type: Catalysis
controller: RNF168
data source: Spike
xref: 18443409
controlled: Ubiquitination.P.RNF168.H2A
control type: ACTIVATION

11090622
type: PublicationXref
title: Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts
id: 11090622
db: PubMed

10550055
type: PublicationXref
title: Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks
id: 10550055
db: PubMed

RNF8
type: Protein
entity reference: RNF8

16169070
type: PublicationXref
title: A human protein-protein interaction network: a resource for annotating the proteome
id: 16169070
db: PubMed

MDC1
type: Protein
entity reference: MDC1

KAT2A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2648
organism: Homo sapiens

RRM2B_DNA
type: DnaRegion
entity reference: RRM2B

http://www.ncbi.nlm.nih.gov/#1107
type: UnificationXref
id: 1107
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#3150
type: UnificationXref
id: 3150
db: Entrez Gene

NBN_inactive
type: Protein
entity reference: NBN

http://www.ncbi.nlm.nih.gov/#1108
type: UnificationXref
id: 1108
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#3151
type: UnificationXref
id: 3151
db: Entrez Gene

10648606
type: PublicationXref
title: A CAF-1-PCNA-mediated chromatin assembly pathway triggered by sensing DNA damage
id: 10648606
db: PubMed

9606
type: UnificationXref
id: 9606
db: taxonomy

RRM2B_inactive
type: Protein
entity reference: RRM2B

TRIM28
type: Protein
entity reference: TRIM28

.ASF1B.PROMOTES.Complex.CAF.1...(CHAF1B).
type: Catalysis
controller: ASF1B
data source: Spike
xref: 11897662
controlled: Physical.Interaction.P.ASF1B.CAF.1
control type: ACTIVATION

.HMGN1.INHIBITS.Complex.SWI/SNF..SMARCA4,.SMARCC2,.SMARCB1.(PBRM1).
type: Catalysis
controller: HMGN1
data source: Spike
xref: 19524541
controlled: Other.I.HMGN1.SWI/SNF
control type: INHIBITION

16024799
type: PublicationXref
title: ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation
id: 16024799
db: PubMed

GADD45A
type: Protein
entity reference: GADD45A

18296440
type: PublicationXref
title: Preferential dimethylation of histone H4 lysine 20 by Suv4-20
id: 18296440
db: PubMed

.Complex.DNA.PK..XRCC6..INHIBITS.TRIM28.
type: Catalysis
controller: DNA-PK.complex
data source: Spike
xref: 19444312
controlled: Phosphorylation.I.DNA.PK.TRIM28
control type: INHIBITION

http://www.ncbi.nlm.nih.gov/#7329
type: UnificationXref
id: 7329
db: Entrez Gene

PhysicalInteraction [H2AFZ -- MAGEC1 ]
type: MolecularInteraction
participant: H2AFZ
participant: MAGEC1
comment: intact:EBI-1199871
xref: 17145710
xref: 17137291

.Complex.NuA4..KAT5,.EP400..PROMOTES.H2AFZ.
type: Catalysis
controller: NuA4.complex
data source: Spike
xref: 16904321
controlled: Acetylation.P.NuA4.H2AFZ
control type: ACTIVATION

.PARP1.PROMOTES.Family.H2A..H2AFX,.H2AFZ.(H2AFZ).
type: Catalysis
controller: PARP1
data source: Spike
xref: 1429884
controlled: Other.P.PARP1.H2A
control type: ACTIVATION

MYST1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#84148
organism: Homo sapiens

.MTA1.INHIBITS.BRCA1.
type: TemplateReactionRegulation
control type: INHIBITION
controller: MTA1
data source: Spike
xref: 17922032
controlled: Transcription.Regulation.I.MTA1.BRCA1

.ATM.UNKNOWN.CHD4.
type: Catalysis
controller: ATM
data source: Spike
xref: 17525332
xref: 20693977
controlled: Phosphorylation.U.ATM.CHD4
control type: ACTIVATION_UNKMECH

WRN_inactive
type: Protein
entity reference: WRN

12660166
type: PublicationXref
title: Pericentric heterochromatin becomes enriched with H2A.Z during early mammalian development
id: 12660166
db: PubMed

PCAF.complex
type: Complex
data source: Spike
component: KAT2B

18001824
type: PublicationXref
title: RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
id: 18001824
db: PubMed

.TRIM28.INHIBITS.STAT1.
type: Catalysis
controller: TRIM28
data source: Spike
xref: 18381204
controlled: Physical.Interaction.I.TRIM28.STAT1
control type: INHIBITION

DDB2
type: Protein
entity reference: DDB2

BRCA1_inactive
type: Protein
entity reference: BRCA1

MCPH1_inactive
type: Protein
entity reference: MCPH1

LIG3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3980
organism: Homo sapiens

SWI/SNF.complex_inactive
type: Protein

.PARP1.PROMOTES.Family.H1...(HIST1H1A).
type: Catalysis
controller: PARP1
data source: Spike
xref: 18927583
controlled: Other.P.PARP1.H1
control type: ACTIVATION

http://www.ncbi.nlm.nih.gov/#1026
type: UnificationXref
id: 1026
db: Entrez Gene

H2AFZ_inactive
type: Protein
entity reference: H2AFZ

BRCA1_RNA
type: RnaRegion
entity reference: BRCA1

14519192
type: PublicationXref
title: KRAB-containing zinc-finger repressor proteins
id: 14519192
db: PubMed

9843217
type: PublicationXref
title: ATM associates with and phosphorylates p53: mapping the region of interaction
id: 9843217
db: PubMed

RPS6KA4
type: Protein
entity reference: RPS6KA4

http://www.ncbi.nlm.nih.gov/#3065
type: UnificationXref
id: 3065
db: Entrez Gene

KDM5B
type: Protein
entity reference: KDM5B

Translation
type: MolecularInteraction
participant: BRCA1_inactive
participant: BRCA1_RNA

.MCPH1.PROMOTES.BRCA2.
type: Catalysis
controller: MCPH1
data source: Spike
xref: 19549900
controlled: Physical.Interaction.P.MCPH1.BRCA2
control type: ACTIVATION

12565178
type: PublicationXref
title: Expression of p53R2, newly p53 target in oral normal epithelium, epithelial dysplasia and squamous cell carcinoma.
id: 12565178
db: PubMed

http://www.ncbi.nlm.nih.gov/#56254
type: UnificationXref
id: 56254
db: Entrez Gene

MTA1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#9112
organism: Homo sapiens

.DOT1L.PROMOTES.Family.H3...(HIST1H3F).
type: Catalysis
controller: DOT1L
data source: Spike
xref: 18022353
xref: 12123582
controlled: Methylation.P.DOT1L.H3
control type: ACTIVATION

.Complex.Gamma.H2AX...MDC1..H2AFX,.MDC1..PROMOTES.Complex.NuA4..KAT5,.EP400.(ACTL6A).
type: Catalysis
controller: Gamma H2AX - MDC1.complex
data source: Spike
xref: 16904321
controlled: Physical.Interaction.P.Gamma.H2AX...MDC1.NuA4
control type: ACTIVATION

ATR-ATRIP.complex
type: Complex
data source: Spike
name: ATR-ATRIP [nucleoplasm]
component: ATR

SRCAP-(SWR-C).complex
type: Complex
data source: Spike
name: SRCAP-(SWR-C)
component: H2AFZ

.ATR.PROMOTES.TP53.
type: Catalysis
controller: ATR
data source: Spike
xref: 9733515
xref: 9733514
xref: 17272272
xref: 9843217
controlled: Phosphorylation.P.ATR.TP53
control type: ACTIVATION

http://www.ncbi.nlm.nih.gov/#59348
type: UnificationXref
id: 59348
db: Entrez Gene

INCENP
type: Protein
entity reference: INCENP

.RNF8.PROMOTES.Family.H2A..H2AFX,.H2AFZ.(H2AFZ).
type: Catalysis
controller: RNF8
data source: Spike
xref: 18001824
xref: 19797077
controlled: Ubiquitination.P.RNF8.H2A
control type: ACTIVATION

.TRIM28.INHIBITS.GADD45A.
type: TemplateReactionRegulation
control type: INHIBITION
controller: TRIM28
data source: Spike
xref: 17942393
controlled: Transcription.Regulation.I.TRIM28.GADD45A

http://www.ncbi.nlm.nih.gov/#84787
type: UnificationXref
id: 84787
db: Entrez Gene

18927583
type: PublicationXref
title: The expanding field of poly(ADP-ribosyl)ation reactions. 'Protein Modifications: Beyond the Usual Suspects' Review Series
id: 18927583
db: PubMed

NFkB.complex_inactive
type: Protein

http://www.ncbi.nlm.nih.gov/#3980
type: UnificationXref
id: 3980
db: Entrez Gene

RPA.complex
type: Complex
data source: Spike
name: Replication Protein A
component: RPA1

.CREBBP.PROMOTES.Family.H3...(HIST1H3F).
type: Catalysis
controller: CREBBP
data source: Spike
xref: 19056256
controlled: Acetylation.P.CREBBP.H3
control type: ACTIVATION

17922032
type: PublicationXref
title: MTA1-mediated transcriptional repression of BRCA1 tumor suppressor gene
id: 17922032
db: PubMed

KAT2B
type: Protein
entity reference: KAT2B

.Complex.DDB1.2.CUL4A....PROMOTES.Family.H3...(HIST1H3F).
type: Catalysis
controller: DDB1-2-CUL4A.complex
data source: Spike
xref: 16678110
controlled: Ubiquitination.P.DDB1.2.CUL4A.H3
control type: ACTIVATION

15923642
type: PublicationXref
title: Involvement of human MOF in ATM function
id: 15923642
db: PubMed

Translation
type: MolecularInteraction
participant: PMAIP1_RNA
participant: PMAIP1

SMARCA4
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6597
organism: Homo sapiens

UCHL5_inactive
type: Protein
entity reference: UCHL5

19342239
type: PublicationXref
title: Crosstalk between histone modifications during the DNA damage response
id: 19342239
db: PubMed

SWI/SNF.complex
type: Complex
data source: Spike
name: SWI/SNF
component: SMARCB1
component: SMARCA4
component: SMARCC2

http://www.ncbi.nlm.nih.gov/#51111
type: UnificationXref
id: 51111
db: Entrez Gene

16774833
type: PublicationXref
title: The ATM-mediated DNA-damage response: taking shape
id: 16774833
db: PubMed

.Family.H4....PROMOTES.TP53BP1.
type: Catalysis
controller: H4.family
data source: Spike
xref: 19218832
xref: 18296440
controlled: Physical.Interaction.P.H4.TP53BP1
control type: ACTIVATION

http://www.ncbi.nlm.nih.gov/#6996
type: UnificationXref
id: 6996
db: Entrez Gene

16189514
type: PublicationXref
title: Towards a proteome-scale map of the human protein-protein interaction network
id: 16189514
db: PubMed

15784679
type: PublicationXref
title: STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage
id: 15784679
db: PubMed

http://www.ncbi.nlm.nih.gov/#55723
type: UnificationXref
id: 55723
db: Entrez Gene

STAT1
type: Protein
entity reference: STAT1

RNF20-RNF40.complex
type: Complex
data source: Spike
name: RNF20-RNF40
component: RNF20
component: RNF40

.RPA1.PROMOTES.Complex.ATR.ATRIP..ATR.(ATRIP).
type: Catalysis
controller: RPA1
data source: Spike
xref: 15743907
controlled: Physical.Interaction.P.RPA1.ATR.ATRIP
control type: ACTIVATION

PhysicalInteraction [Family H1 {} -- SIRT1 ]
type: MolecularInteraction
participant: H1.family
participant: SIRT1
xref: 15469825

ZNF350
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#59348
organism: Homo sapiens

.PARP1.INHIBITS.AURKB.
type: Catalysis
controller: PARP1
data source: Spike
xref: 16647857
controlled: Other.I.PARP1.AURKB
control type: INHIBITION

CEN:F.329895
type: UnificationXref
id: CEN:F-329895
db: Spike DB

ERCC6
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2074
organism: Homo sapiens

TDG_inactive
type: Protein
entity reference: TDG

SIRT1
type: Protein
entity reference: SIRT1

SMARCC2
type: Protein
entity reference: SMARCC2

RNF2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6045
organism: Homo sapiens

KAT2A
type: Protein
entity reference: KAT2A

PhysicalInteraction [DDB2 -- EP300 ]
type: MolecularInteraction
participant: DDB2
participant: EP300
xref: 11425514

18082607
type: PublicationXref
title: PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing
id: 18082607
db: PubMed

STAT1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6772
organism: Homo sapiens

RNF8
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#9025
organism: Homo sapiens

11278964
type: PublicationXref
title: Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies
id: 11278964
db: PubMed

Translation
type: MolecularInteraction
participant: BAX_RNA
participant: BAX

BBC3
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#27113
organism: Homo sapiens

SETD8
type: Protein
entity reference: SETD8

PCNA
type: Protein
entity reference: PCNA

MTA2
type: Protein
entity reference: MTA2

http://www.ncbi.nlm.nih.gov/#84148
type: UnificationXref
id: 84148
db: Entrez Gene

BBC3_RNA
type: RnaRegion
entity reference: BBC3

http://www.ncbi.nlm.nih.gov/#3014
type: UnificationXref
id: 3014
db: Entrez Gene

BRCA2_inactive
type: Protein
entity reference: BRCA2

15386022
type: PublicationXref
title: Role of histone H2A ubiquitination in Polycomb silencing
id: 15386022
db: PubMed

http://www.ncbi.nlm.nih.gov/#3015
type: UnificationXref
id: 3015
db: Entrez Gene

17636032
type: PublicationXref
title: Monoubiquitylation of H2A.Z distinguishes its association with euchromatin or facultative heterochromatin
id: 17636032
db: PubMed

.TRIM28.PROMOTES.Family.HP1..CBX1..
type: Catalysis
controller: TRIM28
data source: Spike
xref: 12154074
xref: 19442252
controlled: Physical.Interaction.P.TRIM28.HP1
control type: ACTIVATION

12781359
type: PublicationXref
title: Chk1 and Chk2 kinases in checkpoint control and cancer
id: 12781359
db: PubMed

16634648
type: PublicationXref
title: Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes
id: 16634648
db: PubMed

PhysicalInteraction [ERCC8 -- Complex TFIIH {} ]
type: MolecularInteraction
participant: TFIIH.complex
participant: ERCC8
xref: 7664335

RPS6KA4_inactive
type: Protein
entity reference: RPS6KA4

RNF168
type: Protein
entity reference: RNF168

DDB1-2-CUL4A.complex
type: Complex
data source: Spike
name: DDB1-DDB2-RBX1-CUL4A ubiquitine ligase E3 complex

PhysicalInteraction [EP300 -- ING2 ]
type: MolecularInteraction
participant: EP300
participant: ING2
xref: 16782091

http://www.ncbi.nlm.nih.gov/#1161
type: UnificationXref
id: 1161
db: Entrez Gene

16904321
type: PublicationXref
title: Tip60 in DNA damage response and growth control: many tricks in one HAT
id: 16904321
db: PubMed

H2AFX
type: Protein
entity reference: H2AFX

.MCPH1.PROMOTES.Complex.SWI/SNF..SMARCA4,.SMARCC2,.SMARCB1.(SMARCC2).
type: Catalysis
controller: MCPH1
data source: Spike
xref: 19525936
controlled: Physical.Interaction.P.MCPH1.SWI/SNF
control type: ACTIVATION

XRCC6
type: Protein
entity reference: XRCC6

H4.family
type: Protein
data source: Spike
xref: ELK:F.000029

12426395
type: PublicationXref
title: MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation
id: 12426395
db: PubMed

.RNF8.PROMOTES.Family.H2B...(HIST1H2BJ).
type: Catalysis
controller: RNF8
data source: Spike
xref: 19015238
controlled: Ubiquitination.P.RNF8.H2B
control type: ACTIVATION

.H2AFX.PROMOTES.MCPH1.
type: Catalysis
controller: H2AFX
data source: Spike
xref: 17599047
controlled: Physical.Interaction.P.H2AFX.MCPH1
control type: ACTIVATION

18784753
type: PublicationXref
title: CSB protein is (a direct target of HIF-1 and) a critical mediator of the hypoxic response
id: 18784753
db: PubMed

.RPS6KA4.PROMOTES.Complex.NFkB...(RELA).
type: Catalysis
controller: RPS6KA4
data source: Spike
xref: 19933278
controlled: Phosphorylation.P.RPS6KA4.NFkB
control type: ACTIVATION

EP400
type: Protein
entity reference: EP400

http://www.ncbi.nlm.nih.gov/#23411
type: UnificationXref
id: 23411
db: Entrez Gene

.Complex.CSA.DDB1.CUL4A..ERCC8..INHIBITS.ERCC6.
type: Catalysis
controller: CSA-DDB1-CUL4A.complex
data source: Spike
xref: 19440044
controlled: Ubiquitination.I.CSA.DDB1.CUL4A.ERCC6
control type: INHIBITION

BAX_DNA
type: DnaRegion
entity reference: BAX

1429884
type: PublicationXref
title: Poly ADP-ribosylation: a histone shuttle mechanism in DNA excision repair
id: 1429884
db: PubMed

PARP1
type: Protein
entity reference: PARP1

19015238
type: PublicationXref
title: Histone ubiquitination associates with BRCA1-dependent DNA damage response
id: 19015238
db: PubMed

11959841
type: PublicationXref
title: setdb1: a novel kap-1 associated hustone h3, lysin 9 specific methyltransferasethat contributes to hp1 mediated silencing of euchromatic genes by krab zinc finger proteins
id: 11959841
db: PubMed

http://www.ncbi.nlm.nih.gov/#83933
type: UnificationXref
id: 83933
db: Entrez Gene

EP300_inactive
type: Protein
entity reference: EP300

HMGN2
type: Protein
entity reference: HMGN2

BBC3
type: Protein
entity reference: BBC3

16990795
type: PublicationXref
title: Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit
id: 16990795
db: PubMed

PhysicalInteraction [ING2 -- TP53 ]
type: MolecularInteraction
participant: ING2
participant: TP53
xref: 16782091

.AURKB.INHIBITS.Family.H3...(HIST1H3F).
type: Catalysis
controller: AURKB
data source: Spike
xref: 16222246
xref: 12234980
controlled: Phosphorylation.I.AURKB.H3
control type: INHIBITION

20094059
type: PublicationXref
title: HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP/p300 and P/CAF-dependent p53 acetylation
id: 20094059
db: PubMed

http://www.ncbi.nlm.nih.gov/#387893
type: UnificationXref
id: 387893
db: Entrez Gene

CHEK2
type: Protein
entity reference: CHEK2

http://www.ncbi.nlm.nih.gov/#9219
type: UnificationXref
id: 9219
db: Entrez Gene

.Complex.SWI/SNF..SMARCA4,.SMARCC2,.SMARCB1..PROMOTES.Complex.Nucleosome..Family.H2A..H2AFX,.H2AFZ.,.Family.H2B...,.Family.H3...,.Family.H4...,.Family.H1....(HIST2H4B).
type: Catalysis
controller: SWI/SNF.complex
data source: Spike
xref: 17291544
controlled: Other.P.SWI/SNF.Nucleosome
control type: ACTIVATION

PhysicalInteraction [CHD3 -- TRIM28 ]
type: MolecularInteraction
participant: CHD3
participant: TRIM28
xref: 16169070

http://www.ncbi.nlm.nih.gov/#9212
type: UnificationXref
id: 9212
db: Entrez Gene

DDB1-CUL4A.complex
type: Complex
data source: Spike
name: DDB1-CUL4A E3-ubiquitination complex

11090615
type: PublicationXref
title: Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1
id: 11090615
db: PubMed

20693977
type: PublicationXref
title: Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4
id: 20693977
db: PubMed

SUV39H1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6839
organism: Homo sapiens

12766152
type: PublicationXref
title: Human claspin is required for replication checkpoint control
id: 12766152
db: PubMed

NuA4.complex_inactive
type: Protein

PhysicalInteraction [ERCC6 -- ERCC8 ]
type: MolecularInteraction
participant: ERCC6
participant: ERCC8
xref: 7664335

19797077
type: PublicationXref
title: Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response
id: 19797077
db: PubMed

.Complex.NuA4..KAT5,.EP400..PROMOTES.Family.H2A..H2AFX,.H2AFZ.(H2AFZ).
type: Catalysis
controller: NuA4.complex
data source: Spike
xref: 16904321
controlled: Acetylation.P.NuA4.H2A
control type: ACTIVATION

16531125
type: PublicationXref
title: gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes
id: 16531125
db: PubMed

XPC
type: Protein
entity reference: XPC