PCNA: structure, functions and interactions
Altered poly(ADP-ribose) metabolism impairs cellular responses to genotoxic stress in a hypomorphic mutant of poly(ADP-ribose) glycohydrolase
RPA physically interacts with the human DNA glycosylase NEIL1 to regulate excision of oxidative DNA base damage in primer-template structures
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice
A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-B activation
Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells
Direct and indirect roles of RECQL4 in modulating base excision repair capacity
Acetylation of WRN protein regulates its stability by inhibiting ubiquitination
Transcription factors NF-YA regulate the induction of human OGG1 following DNA-alkylating agent methylmethane sulfonate (MMS) treatment
The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair
Sequential recruitment of the repair factors during NER: the role of XPG in initiating the resynthesis step
Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus
PhysicalInteraction [MUTYH -- Complex MutS-alpha complex {} ]
DNA Polymerase delta tetramer [nucleoplasm]
A new XRCC1-containing complex and its role in cellular survival of methyl methanesulfonate treatment
Replication factor C recruits DNA polymerase delta to sites of nucleotide excision repair but is not required for PCNA recruitment
Coordination of dual incision and repair synthesis in human nucleotide excision repair
Chk1 in the DNA damage response: conserved roles from yeasts to mammals
Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response
Tumor suppressor APC blocks DNA polymerase beta-dependent strand displacement synthesis during long patch but not short patch base excision repair and increases sensitivity to methylmethane sulfonate
Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells
Suppression of PTEN expression by NF-kappa B prevents apoptosis
The checkpoint clamp, Rad9-Rad1-Hus1 complex, preferentially stimulates the activity of apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta in long patch base excision repair
The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1
Role of glutaredoxin in metabolic oxidative stress. Glutaredoxin as a sensor of oxidative stress mediated by H2O2
Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism
Pro-proliferative FoxM1 is a target of p53-mediated repression
TDP1 serine 81 promotes interaction with DNA ligase IIIalpha and facilitates cell survival following DNA damage
Nox2 and Rac1 regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes
Glutathione in liver diseases and hepatotoxicity
Mechanism of adenomatous polyposis coli (APC)-mediated blockage of long-patch base excision repair
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation
A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1alpha and the HIF-like factor
DNA repair in mammalian cells: Base excision repair: the long and short of it
Biochemical characterization of the WRN-FEN-1 functional interaction
Hypoxia-inducible factor alpha-beta heterdimer
OGG1 is degraded by calpain following oxidative stress and cisplatin exposure
PhysicalInteraction [HMGB1 -- Complex MutS-alpha complex {} ]
The MutSalpha-proliferating cell nuclear antigen interaction in human DNA mismatch repair
Evidence for involvement of HMGB1 protein in human DNA mismatch repair
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
Redox regulation of PI 3-kinase signalling via inactivation of PTEN
The FHA domain of aprataxin interacts with the C-terminal region of XRCC1
AP endonuclease-independent DNA base excision repair in human cells
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
p21/CDKN1A mediates negative regulation of transcription by p53
Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas
Aprataxin, a novel protein that protects against genotoxic stress
DNA Polymerase delta tetramer.complex_inactive
Xeroderma pigmentosum group C protein interacts physically and functionally with thymine DNA glycosylase
DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines
The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA
Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1
Tumor suppressor p53 represses transcription of RECQ4 helicase
Roles of DNA ligase III and XRCC1 in regulating the switch between short patch and long patch BER
Substrate specific stimulation of NEIL1 by WRN but not the other human RecQ helicases
Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK
Role of XRCC1 in the coordination and stimulation of oxidative DNA damage repair initiated by the DNA glycosylase hOGG1
APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks
SIRT1 deacetylates APE1 and regulates cellular base excision repair
Rapid activation of ATR by ionizing radiation requires ATM and Mre11
ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage
AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1
Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts
Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene
A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses
PhysicalInteraction [Complex MutS-alpha complex {} -- PCNA ]
Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300
PhysicalInteraction [NEIL1 -- Complex RPA {RPA1, RPA2} ]
Dose-dependent mutual regulation between Wip1 and p53 following UVC irradiation
The expanding field of poly(ADP-ribosyl)ation reactions. 'Protein Modifications: Beyond the Usual Suspects' Review Series
Base damage and single-strand break repair: mechanisms and functional significance of short- and long-patch repair subpathways
Human MutY homolog, a DNA glycosylase involved in base excision repair, physically and functionally interacts with mismatch repair proteins human MutS homolog 2/human MutS homolog 6
Towards a proteome-scale map of the human protein-protein interaction network
HMGB1 is a cofactor in mammalian base excision repair
Chk1 and Chk2 kinases in checkpoint control and cancer
Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway
Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair
Initiation of base excision repair: glycosylase mechanisms and structures
A new APE1/Ref-1-dependent pathway leading to reduction of NF-kappaB and AP-1, and activation of their DNA-binding activity
Poly ADP-ribosylation: a histone shuttle mechanism in DNA excision repair
Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1
Human claspin is required for replication checkpoint control
Importance of PIKKs in NF-B activation by genotoxic stress