9038370
type: PublicationXref
id: 9038370
title: PCNA: structure, functions and interactions
db: PubMed

.APEX1.PROMOTES.Family.DNA.glycosylases..TDG,.SMUG1,.MPG,.OGG1,.MUTYH,.UNG,.NEIL3,.CCNO,.MBD4,.NEIL1,.NEIL2,.NTHL1.(CCNO).
type: Catalysis
controlled: Other.P.APEX1.DNA.glycosylases
data source: Spike
control type: ACTIVATION
xref: 18259689
controller: APEX1

17276427
type: PublicationXref
id: 17276427
title: Altered poly(ADP-ribose) metabolism impairs cellular responses to genotoxic stress in a hypomorphic mutant of poly(ADP-ribose) glycohydrolase
db: PubMed

http://www.ncbi.nlm.nih.gov/#7295
type: UnificationXref
id: 7295
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#5111
type: UnificationXref
id: 5111
db: Entrez Gene

CDKN1A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1026

20338831
type: PublicationXref
id: 20338831
title: RPA physically interacts with the human DNA glycosylase NEIL1 to regulate excision of oxidative DNA base damage in primer-template structures
db: PubMed

PhysicalInteraction [NEIL1 -- XRCC1 ]
type: MolecularInteraction
participant: NEIL1
participant: XRCC1
xref: 16713569
xref: 15260972

EP300
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2033

PARP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#142

PhysicalInteraction [APEX1 -- TXN ]
type: MolecularInteraction
participant: APEX1
participant: TXN
xref: 9108029

10859164
type: PublicationXref
id: 10859164
title: Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
db: PubMed

10859163
type: PublicationXref
id: 10859163
title: Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice
db: PubMed

.EP300.PROMOTES.WRN.
type: Catalysis
controlled: Acetylation.P.EP300.WRN
data source: Spike
control type: ACTIVATION
xref: 20428248
controller: EP300

20932475
type: PublicationXref
id: 20932475
title: A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-B activation
db: PubMed

http://www.ncbi.nlm.nih.gov/#79661
type: UnificationXref
id: 79661
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#7486
type: UnificationXref
id: 7486
db: Entrez Gene

NEIL1
type: Protein
entity reference: NEIL1

RPA1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6117

http://www.ncbi.nlm.nih.gov/#9401
type: UnificationXref
id: 9401
db: Entrez Gene

.PARP1.INHIBITS.PARP1.
type: Catalysis
controlled: PARylation.I.PARP1.PARP1
data source: Spike
control type: INHIBITION
xref: 17276427
controller: PARP1

AKT1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#207

http://www.ncbi.nlm.nih.gov/#2033
type: UnificationXref
id: 2033
db: Entrez Gene

HMGB1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3146

EP300
type: Protein
entity reference: EP300

H4.family_inactive
type: Protein

WRN
type: Protein
entity reference: WRN

http://www.ncbi.nlm.nih.gov/#4255
type: UnificationXref
id: 4255
db: Entrez Gene

WRN
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7486

19180539
type: PublicationXref
id: 19180539
title: Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells
db: PubMed

Glutathione
type: SmallMoleculeReference
xref: http://www.ebi.ac.uk/chebi/#16856

.ERCC5.PROMOTES.PCNA.
type: Catalysis
controlled: Physical.Interaction.P.ERCC5.PCNA
data source: Spike
control type: ACTIVATION
xref: 18079701
xref: 20713449
xref: 19279666
controller: ERCC5

MAP3K5
type: Protein
entity reference: MAP3K5

http://www.ncbi.nlm.nih.gov/#10309
type: UnificationXref
id: 10309
db: Entrez Gene

NEIL1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#79661

.SIRT6.PROMOTES.Family.H3...(HIST1H3F).
type: Catalysis
controlled: Deacetylation.P.SIRT6.H3
data source: Spike
control type: ACTIVATION
xref: 16439206
xref: 18337721
controller: SIRT6

LIG3
type: Protein
entity reference: LIG3

PhysicalInteraction [APTX -- PARP1 ]
type: MolecularInteraction
participant: PARP1
participant: APTX
xref: 16713569
xref: 15555565
xref: 15044383

CHEK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1111

http://www.ncbi.nlm.nih.gov/#2745
type: UnificationXref
id: 2745
db: Entrez Gene

FEN1
type: Protein
entity reference: FEN1

H2B.family_inactive
type: Protein

H1.family_inactive
type: Protein

RFC.complex
type: Complex
data source: Spike
name: Replication Factor C

ATR
type: Protein
entity reference: ATR

POLL
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#27343

19567405
type: PublicationXref
id: 19567405
title: Direct and indirect roles of RECQL4 in modulating base excision repair capacity
db: PubMed

NEIL3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#55247

RECQL4
type: Protein
entity reference: RECQL4

20428248
type: PublicationXref
id: 20428248
title: Acetylation of WRN protein regulates its stability by inhibiting ubiquitination
db: PubMed

14688259
type: PublicationXref
id: 14688259
title: Transcription factors NF-YA regulate the induction of human OGG1 following DNA-alkylating agent methylmethane sulfonate (MMS) treatment
db: PubMed

NEIL2
type: Protein
entity reference: NEIL2

.Complex.911.complex....PROMOTES.APEX1.
type: Catalysis
controlled: Physical.Interaction.P.911.complex.APEX1
data source: Spike
control type: ACTIVATION
xref: 17426133
controller: 911-complex.complex

RPA2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6118

.CAPN1.INHIBITS.OGG1.
type: Catalysis
controlled: Protein.Degradation.I.CAPN1.OGG1
data source: Spike
control type: INHIBITION
xref: 18294929
controller: CAPN1

.RECQL4.PROMOTES.POLB.
type: Catalysis
controlled: Other.P.RECQL4.POLB
data source: Spike
control type: ACTIVATION
xref: 19567405
controller: RECQL4

http://www.ncbi.nlm.nih.gov/#7150
type: UnificationXref
id: 7150
db: Entrez Gene

.APEX1.INHIBITS.PTH.
type: TemplateReactionRegulation
controlled: Transcription.Regulation.I.APEX1.PTH
control type: INHIBITION
data source: Spike
xref: 14633989
controller: APEX1

TOP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7150

http://www.ebi.ac.uk/chebi/#16856
type: UnificationXref
id: 16856
db: ChEBI

http://www.ncbi.nlm.nih.gov/#10038
type: UnificationXref
id: 10038
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#7157
type: UnificationXref
id: 7157
db: Entrez Gene

ALKBH1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8846

FEN1_inactive
type: Protein
entity reference: FEN1

.RECQL4.PROMOTES.FEN1.
type: Catalysis
controlled: Physical.Interaction.P.RECQL4.FEN1
data source: Spike
control type: ACTIVATION
xref: 19567405
controller: RECQL4

15314187
type: PublicationXref
id: 15314187
title: The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair
db: PubMed

18079701
type: PublicationXref
id: 18079701
title: Sequential recruitment of the repair factors during NER: the role of XPG in initiating the resynthesis step
db: PubMed

NTHL1
type: Protein
entity reference: NTHL1

OGG1
type: Protein
entity reference: OGG1

ATR
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#545

AP-1_I.complex
type: Complex
data source: Spike
name: AP-1 (JUN/:FOS)

16436514
type: PublicationXref
id: 16436514
title: Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus
db: PubMed

PhysicalInteraction [MUTYH -- Complex MutS-alpha complex {} ]
type: MolecularInteraction
participant: MUTYH
participant: MutS-alpha complex.complex
xref: 11801590

http://www.ncbi.nlm.nih.gov/#4968
type: UnificationXref
id: 4968
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#2073
type: UnificationXref
id: 2073
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#4217
type: UnificationXref
id: 4217
db: Entrez Gene

MAP3K5
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4217

ATM
type: Protein
entity reference: ATM

.YBX1.PROMOTES.NEIL2.
type: Catalysis
controlled: Physical.Interaction.P.YBX1.NEIL2
data source: Spike
control type: ACTIVATION
xref: 17611195
controller: YBX1

PhysicalInteraction [APTX -- XRCC1 ]
type: MolecularInteraction
participant: XRCC1
participant: APTX
xref: 15367657
xref: 16713569
xref: 15555565

DNA Polymerase delta tetramer.complex
type: Complex
data source: Spike
name: DNA Polymerase delta tetramer [nucleoplasm]

15367657
type: PublicationXref
id: 15367657
title: A new XRCC1-containing complex and its role in cellular survival of methyl methanesulfonate treatment
db: PubMed

TREX1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#11277

Translation
type: MolecularInteraction
participant: RECQL4_RNA
participant: RECQL4

PCNA
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5111

.APEX1.PROMOTES.FOS.
type: Catalysis
controlled: Physical.Interaction.P.APEX1.FOS
data source: Spike
control type: ACTIVATION
xref: 19180539
controller: APEX1

20713449
type: PublicationXref
id: 20713449
title: Replication factor C recruits DNA polymerase delta to sites of nucleotide excision repair but is not required for PCNA recruitment
db: PubMed

19279666
type: PublicationXref
id: 19279666
title: Coordination of dual incision and repair synthesis in human nucleotide excision repair
db: PubMed

OGG1_DNA
type: DnaRegion
entity reference: OGG1

.PARP1.PROMOTES.Family.H2B...(HIST1H2BJ).
type: Catalysis
controlled: Other.P.PARP1.H2B
data source: Spike
control type: ACTIVATION
xref: 1429884
controller: PARP1

Translation
type: MolecularInteraction
participant: OGG1_inactive
participant: OGG1_RNA

15279789
type: PublicationXref
id: 15279789
title: Chk1 in the DNA damage response: conserved roles from yeasts to mammals
db: PubMed

TP53_inactive
type: Protein
entity reference: TP53

http://www.ncbi.nlm.nih.gov/#7189
type: UnificationXref
id: 7189
db: Entrez Gene

.CDKN1A.INHIBITS.PCNA.
type: Catalysis
controlled: Physical.Interaction.I.CDKN1A.PCNA
data source: Spike
control type: INHIBITION
xref: 17129767
controller: CDKN1A

Homo sapiens
type: BioSource
xref: 9606

.ATR.PROMOTES.TDP1.
type: Catalysis
controlled: Phosphorylation.P.ATR.TDP1
data source: Spike
control type: ACTIVATION
xref: 20009512
controller: ATR

FOS
type: Protein
entity reference: FOS

APTX
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#54840

.Glutathione.PROMOTES.Complex.NFkB...(RELB).
type: Catalysis
controlled: Other.P.Glutathione.NFkB
data source: Spike
control type: ACTIVATION
xref: 18586825
controller: Glutathione

16360315
type: PublicationXref
id: 16360315
title: Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response
db: PubMed

http://www.ncbi.nlm.nih.gov/#4913
type: UnificationXref
id: 4913
db: Entrez Gene

XRCC1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7515

.GLRX.INHIBITS.MAP3K5.
type: Catalysis
controlled: Physical.Interaction.I.GLRX.MAP3K5
data source: Spike
control type: INHIBITION
xref: 12244106
controller: GLRX

http://www.ncbi.nlm.nih.gov/#207
type: UnificationXref
id: 207
db: Entrez Gene

.PTEN.INHIBITS.Complex.NFkB....
type: Catalysis
controlled: Indirect.I.PTEN.NFkB
data source: Spike
control type: INHIBITION
xref: 14729949
controller: PTEN

PTH
type: Protein
entity reference: PTH

15548520
type: PublicationXref
id: 15548520
title: Tumor suppressor APC blocks DNA polymerase beta-dependent strand displacement synthesis during long patch but not short patch base excision repair and increases sensitivity to methylmethane sulfonate
db: PubMed

.CDKN1A.INHIBITS.FEN1.
type: Catalysis
controlled: Physical.Interaction.I.CDKN1A.FEN1
data source: Spike
control type: INHIBITION
xref: 17129767
controller: CDKN1A

SMUG1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#23583

MUTYH_inactive
type: Protein
entity reference: MUTYH

15806160
type: PublicationXref
id: 15806160
title: Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells
db: PubMed

PhysicalInteraction [APEX1 -- FEN1 ]
type: MolecularInteraction
participant: FEN1
participant: APEX1
xref: 16189514
xref: 11601988

SMUG1
type: Protein
entity reference: SMUG1

APEX1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#328

.TXN.PROMOTES.Complex.NFkB...(NFKB1).
type: Catalysis
controlled: Other.P.TXN.NFkB
data source: Spike
control type: ACTIVATION
xref: 18786561
controller: TXN

H2O2
type: SmallMolecule
entity reference: H2O2

EGR1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1958

ATM
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#472

UNG
type: Protein
entity reference: UNG

14729949
type: PublicationXref
id: 14729949
title: Suppression of PTEN expression by NF-kappa B prevents apoptosis
db: PubMed

YBX1_inactive
type: Protein
entity reference: YBX1

.XRCC1.PROMOTES.POLB.
type: Catalysis
controlled: Physical.Interaction.P.XRCC1.POLB
data source: Spike
control type: ACTIVATION
xref: 16442856
controller: XRCC1

http://www.ncbi.nlm.nih.gov/#328
type: UnificationXref
id: 328
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#7515
type: UnificationXref
id: 7515
db: Entrez Gene

17426133
type: PublicationXref
id: 17426133
title: The checkpoint clamp, Rad9-Rad1-Hus1 complex, preferentially stimulates the activity of apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta in long patch base excision repair
db: PubMed

http://www.ncbi.nlm.nih.gov/#641
type: UnificationXref
id: 641
db: Entrez Gene

17611195
type: PublicationXref
id: 17611195
title: The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1
db: PubMed

TDP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#55775

.APEX1.PROMOTES.EGR1.
type: Catalysis
controlled: Physical.Interaction.P.APEX1.EGR1
data source: Spike
control type: ACTIVATION
xref: 19180539
controller: APEX1

12244106
type: PublicationXref
id: 12244106
title: Role of glutaredoxin in metabolic oxidative stress. Glutaredoxin as a sensor of oxidative stress mediated by H2O2
db: PubMed

15272308
type: PublicationXref
id: 15272308
title: Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism
db: PubMed

CHEK1
type: Protein
entity reference: CHEK1

DNA glycosylases.family_inactive
type: Protein

http://www.ncbi.nlm.nih.gov/#252969
type: UnificationXref
id: 252969
db: Entrez Gene

TREX1
type: Protein
entity reference: TREX1

TDG
type: Protein
entity reference: TDG

SIRT6
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#51548

http://www.ncbi.nlm.nih.gov/#545
type: UnificationXref
id: 545
db: Entrez Gene

CDKN1A_RNA
type: RnaRegion
entity reference: CDKN1A

http://www.ncbi.nlm.nih.gov/#823
type: UnificationXref
id: 823
db: Entrez Gene

PARP1_inactive
type: Protein
entity reference: PARP1

ATR-ATRIP.complex_inactive
type: Protein

19749794
type: PublicationXref
id: 19749794
title: Pro-proliferative FoxM1 is a target of p53-mediated repression
db: PubMed

.TXN.INHIBITS.MAP3K5.
type: Catalysis
controlled: Physical.Interaction.I.TXN.MAP3K5
data source: Spike
control type: INHIBITION
xref: 17724081
controller: TXN

TP53
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7157

.H2O2.INHIBITS.PTEN.
type: Catalysis
controlled: Other.I.H2O2.PTEN
data source: Spike
control type: INHIBITION
xref: 14532122
controller: H2O2

MGMT
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4255

PTH_DNA
type: DnaRegion
entity reference: PTH

http://www.ncbi.nlm.nih.gov/#5423
type: UnificationXref
id: 5423
db: Entrez Gene

.PCNA.PROMOTES.Complex.DNA.Polymerase.delta.tetramer...(POLD4).
type: Catalysis
controlled: Physical.Interaction.P.PCNA.DNA.Polymerase.delta.tetramer
data source: Spike
control type: ACTIVATION
xref: 9038370
controller: PCNA

20009512
type: PublicationXref
id: 20009512
title: TDP1 serine 81 promotes interaction with DNA ligase IIIalpha and facilitates cell survival following DNA damage
db: PubMed

Glutathione
type: SmallMolecule
entity reference: Glutathione

PCNA-RFC.complex
type: Complex
data source: Spike
component: PCNA
name: PCNA-RFC

.TP53.INHIBITS.RECQL4.
type: TemplateReactionRegulation
controlled: Transcription.Regulation.I.TP53.RECQL4
control type: INHIBITION
data source: Spike
xref: 15674334
controller: TP53

.APEX1.PROMOTES.Complex.NFkB...(RELB).
type: Catalysis
controlled: Physical.Interaction.P.APEX1.NFkB
data source: Spike
control type: ACTIVATION
xref: 19737086
xref: 19180539
controller: APEX1

POLL
type: Protein
entity reference: POLL

16354686
type: PublicationXref
id: 16354686
title: Nox2 and Rac1 regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes
db: PubMed

18786561
type: PublicationXref
id: 18786561
title: Glutathione in liver diseases and hepatotoxicity
db: PubMed

H2B.family
type: Protein
data source: Spike
xref: ELK:F.000027

Spike
type: Provenance

http://www.ncbi.nlm.nih.gov/#324
type: UnificationXref
id: 324
db: Entrez Gene

TXN
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7295

AKT1_inactive
type: Protein
entity reference: AKT1

.PTEN.INHIBITS.AKT1.
type: Catalysis
controlled: Indirect.I.PTEN.AKT1
data source: Spike
control type: INHIBITION
xref: 15184909
controller: PTEN

http://www.ncbi.nlm.nih.gov/#6117
type: UnificationXref
id: 6117
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#6118
type: UnificationXref
id: 6118
db: Entrez Gene

APEX1_inactive
type: Protein
entity reference: APEX1

17176113
type: PublicationXref
id: 17176113
title: Mechanism of adenomatous polyposis coli (APC)-mediated blockage of long-patch base excision repair
db: PubMed

16439206
type: PublicationXref
id: 16439206
title: Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
db: PubMed

PTH_RNA
type: RnaRegion
entity reference: PTH

RECQL4_RNA
type: RnaRegion
entity reference: RECQL4

.TRAF6.PROMOTES.MAP3K5.
type: Catalysis
controlled: Physical.Interaction.P.TRAF6.MAP3K5
data source: Spike
control type: ACTIVATION
xref: 17724081
controller: TRAF6

15743907
type: PublicationXref
id: 15743907
title: ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation
db: PubMed

.WRN.PROMOTES.NEIL1.
type: Catalysis
controlled: Physical.Interaction.P.WRN.NEIL1
data source: Spike
control type: ACTIVATION
xref: 20346739
xref: 17611195
controller: WRN

.APEX1.PROMOTES.TP53.
type: Catalysis
controlled: Physical.Interaction.P.APEX1.TP53
data source: Spike
control type: ACTIVATION
xref: 19737086
xref: 19180539
controller: APEX1

Translation
type: MolecularInteraction
participant: PTH
participant: PTH_RNA

http://www.ncbi.nlm.nih.gov/#5741
type: UnificationXref
id: 5741
db: Entrez Gene

TDG
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6996

DNA glycosylases.family
type: Protein
data source: Spike
member physical entity: TDG
member physical entity: NEIL3
member physical entity: NEIL1
member physical entity: UNG
member physical entity: MUTYH
member physical entity: SMUG1
member physical entity: NTHL1
member physical entity: OGG1
member physical entity: CCNO
member physical entity: MBD4
member physical entity: MPG
member physical entity: NEIL2
xref: CEN:F.329962

10671489
type: PublicationXref
id: 10671489
title: A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1alpha and the HIF-like factor
db: PubMed

APLF
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#200558

FEN1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2237

H3.family
type: Protein
data source: Spike
xref: ELK:F.000028

MutS-alpha complex.complex
type: Complex
data source: Spike
name: MSH2-MSH6

MUTYH
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4595

911-complex.complex_inactive
type: Protein

.TP53.PROMOTES.CDKN1A.
type: TemplateReactionRegulation
controlled: Transcription.Regulation.P.TP53.CDKN1A
control type: ACTIVATION
data source: Spike
xref: 12748190
xref: 21163364
xref: 19749794
controller: TP53

19153658
type: PublicationXref
id: 19153658
title: DNA repair in mammalian cells: Base excision repair: the long and short of it
db: PubMed

12356323
type: PublicationXref
id: 12356323
title: Biochemical characterization of the WRN-FEN-1 functional interaction
db: PubMed

911-complex.complex
type: Complex
data source: Spike
name: 911

http://www.ncbi.nlm.nih.gov/#472
type: UnificationXref
id: 472
db: Entrez Gene

SIRT1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#23411

EGR1
type: Protein
entity reference: EGR1

.PARP1.PROMOTES.Family.H2A...(H2AFZ).
type: Catalysis
controlled: Other.P.PARP1.H2A
data source: Spike
control type: ACTIVATION
xref: 1429884
controller: PARP1

CAPN1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#823

http://www.ncbi.nlm.nih.gov/#4904
type: UnificationXref
id: 4904
db: Entrez Gene

DNA-PK.complex
type: Complex
data source: Spike
name: DNA-PK

XRCC1
type: Protein
entity reference: XRCC1

APC
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#324

ssDNA-RPA.complex
type: Complex
data source: Spike
component: RPA1
component: RPA2
name: single stranded DNA

.AKT1.PROMOTES.Complex.NFkB....
type: Catalysis
controlled: Phosphorylation.P.AKT1.NFkB
data source: Spike
control type: ACTIVATION
xref: 15184909
controller: AKT1

AKT1
type: Protein
entity reference: AKT1

H2O2
type: SmallMoleculeReference
xref: http://www.ebi.ac.uk/chebi/#16240

HIF.complex
type: Complex
data source: Spike
name: Hypoxia-inducible factor alpha-beta heterdimer

18294929
type: PublicationXref
id: 18294929
title: OGG1 is degraded by calpain following oxidative stress and cisplatin exposure
db: PubMed

TDP1_inactive
type: Protein
entity reference: TDP1

PhysicalInteraction [HMGB1 -- Complex MutS-alpha complex {} ]
type: MolecularInteraction
participant: HMGB1
participant: MutS-alpha complex.complex
xref: 15014079

http://www.ncbi.nlm.nih.gov/#5728
type: UnificationXref
id: 5728
db: Entrez Gene

PhysicalInteraction [HMGB1 -- POLB ]
type: MolecularInteraction
participant: POLB
participant: HMGB1
xref: 17803946

MPG
type: Protein
entity reference: MPG

NTHL1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4913

.PARP1.PROMOTES.Family.H4...(HIST2H4B).
type: Catalysis
controlled: Other.P.PARP1.H4
data source: Spike
control type: ACTIVATION
xref: 1429884
controller: PARP1

PTEN_inactive
type: Protein
entity reference: PTEN

H3.family_inactive
type: Protein

RPA1
type: Protein
entity reference: RPA1

CAPN1
type: Protein
entity reference: CAPN1

18326858
type: PublicationXref
id: 18326858
title: The MutSalpha-proliferating cell nuclear antigen interaction in human DNA mismatch repair
db: PubMed

CCNO
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#10309

PhysicalInteraction [FEN1 -- HMGB1 ]
type: MolecularInteraction
participant: FEN1
participant: HMGB1
xref: 17803946

18259689
type: PublicationXref
id: 18259689
title: Base excision DNA repair
db: PubMed

PCNA_inactive
type: Protein
entity reference: PCNA

BLM
type: Protein
entity reference: BLM

http://www.ncbi.nlm.nih.gov/#4595
type: UnificationXref
id: 4595
db: Entrez Gene

CDKN1A_DNA
type: DnaRegion
entity reference: CDKN1A

H2A.family
type: Protein
data source: Spike
xref: ELK:F.000026

http://www.ncbi.nlm.nih.gov/#2353
type: UnificationXref
id: 2353
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#8930
type: UnificationXref
id: 8930
db: Entrez Gene

TP53
type: Protein
entity reference: TP53

.ATR.PROMOTES.CHEK1.
type: Catalysis
controlled: Phosphorylation.P.ATR.CHEK1
data source: Spike
control type: ACTIVATION
xref: 16431910
xref: 15279789
xref: 12766152
xref: 12781359
xref: 15190204
xref: 15272308
xref: 10859164
xref: 10859163
xref: 16360315
xref: 11090622
xref: 11390642
controller: ATR

GLRX
type: Protein
entity reference: GLRX

ERCC5
type: Protein
entity reference: ERCC5

15014079
type: PublicationXref
id: 15014079
title: Evidence for involvement of HMGB1 protein in human DNA mismatch repair
db: PubMed

18337721
type: PublicationXref
id: 18337721
title: SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
db: PubMed

http://www.ncbi.nlm.nih.gov/#8846
type: UnificationXref
id: 8846
db: Entrez Gene

APTX
type: Protein
entity reference: APTX

.APEX1.PROMOTES.Complex.HIF...(ARNT).
type: Catalysis
controlled: Other.P.APEX1.HIF
data source: Spike
control type: ACTIVATION
xref: 10671489
controller: APEX1

ELK:F.000026
type: UnificationXref
id: ELK:F-000026
db: Spike DB

PhysicalInteraction [APLF -- XRCC1 ]
type: MolecularInteraction
participant: APLF
participant: XRCC1
xref: 17353262

ELK:F.000028
type: UnificationXref
id: ELK:F-000028
db: Spike DB

NFkB.complex
type: Complex
data source: Spike
name: Nuclear factor kappa-B

ELK:F.000027
type: UnificationXref
id: ELK:F-000027
db: Spike DB

POLB
type: Protein
entity reference: POLB

.SIRT1.PROMOTES.APEX1.
type: Catalysis
controlled: Deacetylation.P.SIRT1.APEX1
data source: Spike
control type: ACTIVATION
xref: 19934257
controller: SIRT1

ELK:F.000029
type: UnificationXref
id: ELK:F-000029
db: Spike DB

OGG1_RNA
type: RnaRegion
entity reference: OGG1

TXN
type: Protein
entity reference: TXN

.ATR.PROMOTES.Complex.911.complex...(RAD1).
type: Catalysis
controlled: Phosphorylation.P.ATR.911.complex
data source: Spike
control type: ACTIVATION
xref: 16436514
controller: ATR

.PARP1.PROMOTES.Family.H3...(HIST1H3F).
type: Catalysis
controlled: Other.P.PARP1.H3
data source: Spike
control type: ACTIVATION
xref: 1429884
controller: PARP1

14532122
type: PublicationXref
id: 14532122
title: Redox regulation of PI 3-kinase signalling via inactivation of PTEN
db: PubMed

15555565
type: PublicationXref
id: 15555565
title: The FHA domain of aprataxin interacts with the C-terminal region of XRCC1
db: PubMed

.EP300.INHIBITS.FEN1.
type: Catalysis
controlled: Acetylation.I.EP300.FEN1
data source: Spike
control type: INHIBITION
xref: 11430825
controller: EP300

15260972
type: PublicationXref
id: 15260972
title: AP endonuclease-independent DNA base excision repair in human cells
db: PubMed

APEX1
type: Protein
entity reference: APEX1

http://www.ncbi.nlm.nih.gov/#2237
type: UnificationXref
id: 2237
db: Entrez Gene

http://www.ebi.ac.uk/chebi/#16240
type: UnificationXref
id: 16240
db: ChEBI

TRAF6
type: Protein
entity reference: TRAF6

PARP2
type: Protein
entity reference: PARP2

POLB
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5423

.APEX1.PROMOTES.Complex.AP.1 I...(FOSL1).
type: Catalysis
controlled: Other.P.APEX1.AP.1 I
data source: Spike
control type: ACTIVATION
xref: 18786561
controller: APEX1

NEIL2_inactive
type: Protein
entity reference: NEIL2

MAP3K5_inactive
type: Protein
entity reference: MAP3K5

HIF.complex_inactive
type: Protein

H1.family
type: Protein
data source: Spike
xref: CEN:F.329895

H2A.family_inactive
type: Protein

LIG3-XRCC1.complex
type: Complex
data source: Spike
component: LIG3
component: XRCC1
name: LIG3-XRCC1

16713569
type: PublicationXref
id: 16713569
title: A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
db: PubMed

.H2O2.PROMOTES.TRAF6.
type: Catalysis
controlled: Other.P.H2O2.TRAF6
data source: Spike
control type: ACTIVATION
xref: 16354686
controller: H2O2

MGMT
type: Protein
entity reference: MGMT

11390642
type: PublicationXref
id: 11390642
title: ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
db: PubMed

http://www.ncbi.nlm.nih.gov/#54840
type: UnificationXref
id: 54840
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#142
type: UnificationXref
id: 142
db: Entrez Gene

12748190
type: PublicationXref
id: 12748190
title: p21/CDKN1A mediates negative regulation of transcription by p53
db: PubMed

15184909
type: PublicationXref
id: 15184909
title: Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas
db: PubMed

15044383
type: PublicationXref
id: 15044383
title: Aprataxin, a novel protein that protects against genotoxic stress
db: PubMed

XPC-HRAD23B.complex
type: Complex
data source: Spike
name: XPC-HARD23B

DNA Polymerase delta tetramer.complex_inactive
type: Protein

12505994
type: PublicationXref
id: 12505994
title: Xeroderma pigmentosum group C protein interacts physically and functionally with thymine DNA glycosylase
db: PubMed

9592149
type: PublicationXref
id: 9592149
title: DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines
db: PubMed

MBD4
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8930

YBX1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4904

Translation
type: MolecularInteraction
participant: CDKN1A
participant: CDKN1A_RNA

PhysicalInteraction [APEX1 -- HMGB1 ]
type: MolecularInteraction
participant: APEX1
participant: HMGB1
xref: 17803946

16326861
type: PublicationXref
id: 16326861
title: The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA
db: PubMed

15744309
type: PublicationXref
id: 15744309
title: Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1
db: PubMed

15674334
type: PublicationXref
id: 15674334
title: Tumor suppressor p53 represses transcription of RECQ4 helicase
db: PubMed

PhysicalInteraction [LIG3 -- TDP1 ]
type: MolecularInteraction
participant: TDP1
participant: LIG3
xref: 20009512
xref: 15744309

DNA polymerase epsilon.complex
type: Complex
data source: Spike
name: DNA polymerase epsilon [nucleoplasm]

RECQL4
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9401

http://www.ncbi.nlm.nih.gov/#4350
type: UnificationXref
id: 4350
db: Entrez Gene

MPG
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4350

http://www.ncbi.nlm.nih.gov/#51548
type: UnificationXref
id: 51548
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#27343
type: UnificationXref
id: 27343
db: Entrez Gene

16442856
type: PublicationXref
id: 16442856
title: Roles of DNA ligase III and XRCC1 in regulating the switch between short patch and long patch BER
db: PubMed

RECQL4_DNA
type: DnaRegion
entity reference: RECQL4

TOP1
type: Protein
entity reference: TOP1

20346739
type: PublicationXref
id: 20346739
title: Substrate specific stimulation of NEIL1 by WRN but not the other human RecQ helicases
db: PubMed

19851285
type: PublicationXref
id: 19851285
title: Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK
db: PubMed

CDKN1A
type: Protein
entity reference: CDKN1A

12933815
type: PublicationXref
id: 12933815
title: Role of XRCC1 in the coordination and stimulation of oxidative DNA damage repair initiated by the DNA glycosylase hOGG1
db: PubMed

17353262
type: PublicationXref
id: 17353262
title: APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks
db: PubMed

.Complex.911.complex....PROMOTES.MUTYH.
type: Catalysis
controlled: Physical.Interaction.P.911.complex.MUTYH
data source: Spike
control type: ACTIVATION
xref: 18259689
controller: 911-complex.complex

PhysicalInteraction [RPA2 -- UNG ]
type: MolecularInteraction
participant: UNG
participant: RPA2
xref: 16189514
xref: 10872450

19934257
type: PublicationXref
id: 19934257
title: SIRT1 deacetylates APE1 and regulates cellular base excision repair
db: PubMed

BLM
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#641

EGR1_inactive
type: Protein
entity reference: EGR1

16431910
type: PublicationXref
id: 16431910
title: Rapid activation of ATR by ionizing radiation requires ATM and Mre11
db: PubMed

15190204
type: PublicationXref
id: 15190204
title: ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage
db: PubMed

9108029
type: PublicationXref
id: 9108029
title: AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1
db: PubMed

CHEK1_inactive
type: Protein
entity reference: CHEK1

http://www.ncbi.nlm.nih.gov/#1111
type: UnificationXref
id: 1111
db: Entrez Gene

11090622
type: PublicationXref
id: 11090622
title: Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts
db: PubMed

TRAF6
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7189

ALKBH1
type: Protein
entity reference: ALKBH1

GLRX
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2745

9606
type: UnificationXref
id: 9606
db: taxonomy

14633989
type: PublicationXref
id: 14633989
title: Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene
db: PubMed

17396150
type: PublicationXref
id: 17396150
title: A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses
db: PubMed

PhysicalInteraction [APEX1 -- POLB ]
type: MolecularInteraction
participant: POLB
participant: APEX1
xref: 9207062

POLB_inactive
type: Protein
entity reference: POLB

PhysicalInteraction [Complex MutS-alpha complex {} -- PCNA ]
type: MolecularInteraction
participant: PCNA
participant: MutS-alpha complex.complex
xref: 18326858

HMGB1
type: Protein
entity reference: HMGB1

http://www.ncbi.nlm.nih.gov/#11277
type: UnificationXref
id: 11277
db: Entrez Gene

WRN_inactive
type: Protein
entity reference: WRN

TDP1
type: Protein
entity reference: TDP1

.APLF.PROMOTES.PARP1.
type: Catalysis
controlled: Physical.Interaction.P.APLF.PARP1
data source: Spike
control type: ACTIVATION
xref: 17396150
controller: APLF

LIG3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3980

.PARP1.PROMOTES.Family.H1...(HIST1H1A).
type: Catalysis
controlled: Other.P.PARP1.H1
data source: Spike
control type: ACTIVATION
xref: 18927583
controller: PARP1

http://www.ncbi.nlm.nih.gov/#1026
type: UnificationXref
id: 1026
db: Entrez Gene

NF-Y.complex
type: Complex
data source: Spike
name: NF-Y (trimer) transcription factor

CCNO
type: Protein
entity reference: CCNO

.Complex.XPC.HRAD23B....PROMOTES.TDG.
type: Catalysis
controlled: Physical.Interaction.P.XPC.HRAD23B.TDG
data source: Spike
control type: ACTIVATION
xref: 12505994
controller: XPC-HRAD23B.complex

.APC.INHIBITS.POLB.
type: Catalysis
controlled: Other.I.APC.POLB
data source: Spike
control type: INHIBITION
xref: 15548520
xref: 17176113
controller: APC

RPA2
type: Protein
entity reference: RPA2

FOS
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2353

11430825
type: PublicationXref
id: 11430825
title: Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300
db: PubMed

http://www.ncbi.nlm.nih.gov/#200558
type: UnificationXref
id: 200558
db: Entrez Gene

PhysicalInteraction [NEIL1 -- Complex RPA {RPA1, RPA2} ]
type: MolecularInteraction
participant: RPA.complex
participant: NEIL1
xref: 20338831

21163364
type: PublicationXref
id: 21163364
title: Dose-dependent mutual regulation between Wip1 and p53 following UVC irradiation
db: PubMed

FOS_inactive
type: Protein
entity reference: FOS

PTEN
type: Protein
entity reference: PTEN

ATR-ATRIP.complex
type: Complex
data source: Spike
component: ATR
name: ATR-ATRIP [nucleoplasm]

PhysicalInteraction [PARP1 -- XRCC1 ]
type: MolecularInteraction
participant: PARP1
participant: XRCC1
xref: 16713569
xref: 9592149

OGG1_inactive
type: Protein
entity reference: OGG1

TRAF6_inactive
type: Protein
entity reference: TRAF6

SIRT6
type: Protein
entity reference: SIRT6

.AKT1.PROMOTES.YBX1.
type: Catalysis
controlled: Phosphorylation.P.AKT1.YBX1
data source: Spike
control type: ACTIVATION
xref: 15806160
controller: AKT1

18927583
type: PublicationXref
id: 18927583
title: The expanding field of poly(ADP-ribosyl)ation reactions. 'Protein Modifications: Beyond the Usual Suspects' Review Series
db: PubMed

http://www.ncbi.nlm.nih.gov/#3980
type: UnificationXref
id: 3980
db: Entrez Gene

NFkB.complex_inactive
type: Protein

RPA.complex
type: Complex
data source: Spike
component: RPA1
component: RPA2
name: Replication Protein A

17129767
type: PublicationXref
id: 17129767
title: Base damage and single-strand break repair: mechanisms and functional significance of short- and long-patch repair subpathways
db: PubMed

.RECQL4.PROMOTES.APEX1.
type: Catalysis
controlled: mRNA.stability.P.RECQL4.APEX1
data source: Spike
control type: ACTIVATION
xref: 19567405
controller: RECQL4

mitochondrial POLG.complex
type: Complex
data source: Spike
name: mitochondrial DNA polymerase gamma

MBD4
type: Protein
entity reference: MBD4

http://www.ncbi.nlm.nih.gov/#23583
type: UnificationXref
id: 23583
db: Entrez Gene

11801590
type: PublicationXref
id: 11801590
title: Human MutY homolog, a DNA glycosylase involved in base excision repair, physically and functionally interacts with mismatch repair proteins human MutS homolog 2/human MutS homolog 6
db: PubMed

http://www.ncbi.nlm.nih.gov/#6996
type: UnificationXref
id: 6996
db: Entrez Gene

MUTYH
type: Protein
entity reference: MUTYH

16189514
type: PublicationXref
id: 16189514
title: Towards a proteome-scale map of the human protein-protein interaction network
db: PubMed

17803946
type: PublicationXref
id: 17803946
title: HMGB1 is a cofactor in mammalian base excision repair
db: PubMed

.RPA1.PROMOTES.Complex.ATR.ATRIP..ATR.(ATRIP).
type: Catalysis
controlled: Physical.Interaction.P.RPA1.ATR.ATRIP
data source: Spike
control type: ACTIVATION
xref: 15743907
controller: RPA1

.Complex.NF.Y....PROMOTES.OGG1.
type: TemplateReactionRegulation
controlled: Transcription.Regulation.P.NF.Y.OGG1
control type: ACTIVATION
data source: Spike
xref: 14688259
controller: NF-Y.complex

CEN:F.329895
type: UnificationXref
id: CEN:F-329895
db: Spike DB

APLF
type: Protein
entity reference: APLF

TDG_inactive
type: Protein
entity reference: TDG

SIRT1
type: Protein
entity reference: SIRT1

http://www.ncbi.nlm.nih.gov/#55247
type: UnificationXref
id: 55247
db: Entrez Gene

PTEN
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5728

PCNA
type: Protein
entity reference: PCNA

.ATM.PROMOTES.TDP1.
type: Catalysis
controlled: Phosphorylation.P.ATM.TDP1
data source: Spike
control type: ACTIVATION
xref: 19851285
controller: ATM

OGG1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4968

12781359
type: PublicationXref
id: 12781359
title: Chk1 and Chk2 kinases in checkpoint control and cancer
db: PubMed

9207062
type: PublicationXref
id: 9207062
title: Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway
db: PubMed

11601988
type: PublicationXref
id: 11601988
title: Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair
db: PubMed

PhysicalInteraction [OGG1 -- XRCC1 ]
type: MolecularInteraction
participant: OGG1
participant: XRCC1
xref: 12933815
xref: 16713569

ERCC5
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2073

.Complex.DNA.PK....PROMOTES.TDP1.
type: Catalysis
controlled: Phosphorylation.P.DNA.PK.TDP1
data source: Spike
control type: ACTIVATION
xref: 19851285
controller: DNA-PK.complex

.BLM.PROMOTES.FEN1.
type: Catalysis
controlled: Physical.Interaction.P.BLM.FEN1
data source: Spike
control type: ACTIVATION
xref: 12356323
xref: 16326861
controller: BLM

H4.family
type: Protein
data source: Spike
xref: ELK:F.000029

.WRN.PROMOTES.FEN1.
type: Catalysis
controlled: Physical.Interaction.P.WRN.FEN1
data source: Spike
control type: ACTIVATION
xref: 16326861
controller: WRN

PhysicalInteraction [MUTYH -- PCNA ]
type: MolecularInteraction
participant: PCNA
participant: MUTYH
xref: 19153658
xref: 16189514

10872450
type: PublicationXref
id: 10872450
title: Initiation of base excision repair: glycosylase mechanisms and structures
db: PubMed

18586825
type: PublicationXref
id: 18586825
title: A new APE1/Ref-1-dependent pathway leading to reduction of NF-kappaB and AP-1, and activation of their DNA-binding activity
db: PubMed

APC
type: Protein
entity reference: APC

.ATM.PROMOTES.TRAF6.
type: Catalysis
controlled: Physical.Interaction.P.ATM.TRAF6
data source: Spike
control type: ACTIVATION
xref: 21872579
xref: 20932475
controller: ATM

NEIL1_inactive
type: Protein
entity reference: NEIL1

http://www.ncbi.nlm.nih.gov/#23411
type: UnificationXref
id: 23411
db: Entrez Gene

PARP2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#10038

1429884
type: PublicationXref
id: 1429884
title: Poly ADP-ribosylation: a histone shuttle mechanism in DNA excision repair
db: PubMed

PARP1
type: Protein
entity reference: PARP1

CEN:F.329962
type: UnificationXref
id: CEN:F-329962
db: Spike DB

UNG
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7374

YBX1
type: Protein
entity reference: YBX1

NEIL2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#252969

http://www.ncbi.nlm.nih.gov/#55775
type: UnificationXref
id: 55775
db: Entrez Gene

17724081
type: PublicationXref
id: 17724081
title: Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1
db: PubMed

PTH
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5741

AP-1_I.complex_inactive
type: Protein

http://www.ncbi.nlm.nih.gov/#1958
type: UnificationXref
id: 1958
db: Entrez Gene

.APC.INHIBITS.FEN1.
type: Catalysis
controlled: mRNA.stability.I.APC.FEN1
data source: Spike
control type: INHIBITION
xref: 15548520
xref: 17176113
controller: APC

NEIL3
type: Protein
entity reference: NEIL3

19737086
type: PublicationXref
id: 19737086
title: Nuclear redox signalling
db: PubMed

12766152
type: PublicationXref
id: 12766152
title: Human claspin is required for replication checkpoint control
db: PubMed

http://www.ncbi.nlm.nih.gov/#3146
type: UnificationXref
id: 3146
db: Entrez Gene

21872579
type: PublicationXref
id: 21872579
title: Importance of PIKKs in NF-B activation by genotoxic stress
db: PubMed

http://www.ncbi.nlm.nih.gov/#7374
type: UnificationXref
id: 7374
db: Entrez Gene

.Complex.911.complex....PROMOTES.POLB.
type: Catalysis
controlled: Physical.Interaction.P.911.complex.POLB
data source: Spike
control type: ACTIVATION
xref: 15314187
controller: 911-complex.complex