Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice
PhysicalInteraction [DCLRE1B -- Complex MUS81-EME1 {MUS81, EME1} ]
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair
Polymorphic TP53BP1 and TP53 gene interactions associated with risk of squamous cell carcinoma of the head and neck
SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint
MRE11 complex links RECQ5 helicase to sites of DNA damage
Ku heterodimer (Ku-70-ku-80) XRCC6-XRCC5
The DNA damage response: ten years after
xeroderma pigmentosum protein A-replication protein A
FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia
BLM, RPAs (1,2,3) FA and topoisomerase III alpha
Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks
Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair
Human Rad51 amino acid residues required for Rad52 binding
DNA polymerase POLN participates in cross-link repair and homologous recombination
Lysine 63-polyubiquitination guards against translesion synthesis-induced mutations
Interaction between the BRCT domain of REV1 and and monoubiquitinated PCNA
Regulation of DNA repair by ubiquitylation
The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair
Transcriptional regulation of the PCNA promoter by p53
Functional analysis of p53 binding under differential stresses
The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM
Activation and regulation of ATM kinase activity in response to DNA double-strand breaks
Interaction with DNA polymerase eta is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells
HCLK2 is required for activity of the DNA damage response kinase ATR
Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance
Claspin, a regulator of Chk1 in DNA replication stress pathway
Chk1 in the DNA damage response: conserved roles from yeasts to mammals
The Fanconi anemia pathway: Insights from somatic cell genetics using DT40 cell line
FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway
Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks
BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control
Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response
PhysicalInteraction [DCLRE1A -- TP53BP1 ]
IntAct--open source resource for molecular interaction data
The Fanconi Anemia/BRCA pathway: new faces in the crowd
FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
Enhanced phosphorylation of p53 by ATM in response to DNA damage
RAD18 transmits DNA damage signalling to elicit homologous recombination repair
Phosphorylation of Artemis following irradiation-induced DNA damage
Understanding the functions of BRCA1 in the DNA-damage response
Chk1 and Claspin potentiate PCNA ubiquitination
Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway
Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism
PhysicalInteraction [HMGB1 -- Complex XPA-RPA {RPA1} ]
ATR-mediated phosphorylation of DNA polymerase is needed for efficient recovery from UV damage
ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses
PhysicalInteraction [FANCM -- Complex MHF {} ]
Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway
Fanconi anemia: a disorder defective in the DNA damage response
ATR-FT-IR membrane-based sensor for integrated microliquid-liquid extraction and detection
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis
Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro
RAD51 localization and activation following DNA damage
PhysicalInteraction [SLX4 -- Complex MUS81-EME1 {MUS81, EME1} ]
ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation
DNA damage induced Pol eta recruitment takes place independently of the cell cycle phase
Multiple roles of ERCC1-XPF in mammalian interstrand crosslink repair
A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2
Physical and functional interactions of human DNA polymerase eta with PCNA
Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus
Extensive ssDNA end formation at DNA double-strand breaks in non-homologous end-joining deficient cells during the S phase
Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks
TopBP1 and DNA polymerase alpha-mediated recruitment of the 9-1-1 complex to stalled replication forks: implications for a replication restart-based mechanism for ATR checkpoint activation
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
Regulation of DNA repair throughout the cell cycle
PhysicalInteraction [DCLRE1B -- Complex MRN {NBN} ]
Characterization of a carboxy-terminal BRCA1 interacting protein
BRCT repeats as phosphopeptide-binding modules involved in protein targeting
Activation of ubiquitin-dependent DNA damage bypass is mediated by replication protein a
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
PhysicalInteraction [DCLRE1B -- FANCD2 ]
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage
RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network
A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein
ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses
The Fanconi family adds a fraternal twin
Interaction of hREV1 with three human Y-family DNA polymerases
Recognition of DNA double strand breaks by the BRCA1 tumor suppressor network
Human HMGB1 directly facilitates interactions between nucleotide excision repair proteins on triplex-directed psoralen interstrand crosslinks
The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR
Interplay between human DNA repair proteins at a unique double-strand break in vivo
ATM and related protein kinases: safeguarding genome integrity
The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction
Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1
Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2
Rapid activation of ATR by ionizing radiation requires ATM and Mre11
ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage
Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks
Fanconi anemia complementation group FANCD2 protein serine 331 phosphorylation is important for fanconi anemia pathway function and BRCA2 interaction
Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links
The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment
Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response
Circadian proteins in the regulation of cell cycle and genotoxic stress responses
ATM associates with and phosphorylates p53: mapping the region of interaction
Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro
Rad18 regulates DNA polymerase kappa and is required for recovery from S-phase checkpoint-mediated arrest
Stabilizing and remodeling the blocked DNA replication fork: anchoring FANCM and the Fanconi anemia damage response
Repair of DNA double strand breaks by non-homologous end joining
PhysicalInteraction [CLK2 -- Complex FANCM-FAAP24 {FANCM} ]
Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies
MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM
A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability
Chk1 and Chk2 kinases in checkpoint control and cancer
Ubiquitin-dependent regulation of translesion polymerases
PhysicalInteraction [Complex MutS-beta complex {} -- Complex XPA-RPA {RPA1} ]
PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene
PhysicalInteraction [HMGB1 -- Complex XPC-HRAD23B {} ]
Interplay between Ku, artemis and DNA-PKcs at DNA ends
Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1
FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by replication protein A to unwind the damaged DNA substrate in a strand-specific manner
Human claspin is required for replication checkpoint control
Functional interaction between the Fanconi Anemia D2 protein and proliferating cell nuclear antigen (PCNA) via a conserved putative PCNA interaction motif
Human Rad54 protein stimulates human Mus81-Eme1 endonuclease
FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex
gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes