http://www.ncbi.nlm.nih.gov/#113510
type: UnificationXref
id: 113510
db: Entrez Gene

Translation
type: MolecularInteraction
participant: PCNA_inactive
participant: PCNA_RNA

http://www.ncbi.nlm.nih.gov/#83990
type: UnificationXref
id: 83990
db: Entrez Gene

TIPIN
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#54962
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#7398
type: UnificationXref
id: 7398
db: Entrez Gene

TP53BP1
type: Protein
entity reference: TP53BP1

PhysicalInteraction [POLK -- REV1 ]
type: MolecularInteraction
xref: 15189446
participant: POLK
participant: REV1

.Complex.Gamma.H2AX...MDC1..H2AFX..PROMOTES.Complex.UIMCI.BRCA1.BARD1...(BRCA1).
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.Gamma.H2AX...MDC1.UIMCI.BRCA1.BARD1
xref: 18369654
controller: Gamma H2AX - MDC1
data source: Spike

http://www.ncbi.nlm.nih.gov/#84464
type: UnificationXref
id: 84464
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#5111
type: UnificationXref
id: 5111
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#57697
type: UnificationXref
id: 57697
db: Entrez Gene

UIMCI-BRCA1-BARD1-BRCC3
type: Complex
display name: UIMCI-BRCA1-BARD1.complex
data source: Spike

.Complex.Gamma.H2AX...MDC1..H2AFX..PROMOTES.NBN.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.Gamma.H2AX...MDC1.NBN
xref: 17963495
controller: Gamma H2AX - MDC1
data source: Spike

CLSPN
type: Protein
entity reference: CLSPN

11485998
type: PublicationXref
id: 11485998
db: PubMed
title: Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7

.RAD54L.PROMOTES.Complex.MUS81.EME1..MUS81,.EME1.(MUS81).
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.RAD54L.MUS81.EME1
xref: 19017809
controller: RAD54L
data source: Spike

10859164
type: PublicationXref
id: 10859164
db: PubMed
title: Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

10859163
type: PublicationXref
id: 10859163
db: PubMed
title: Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice

FANCI
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#55215
organism: Homo sapiens

MAD2L2
type: Protein
entity reference: MAD2L2

http://www.ncbi.nlm.nih.gov/#9156
type: UnificationXref
id: 9156
db: Entrez Gene

EXO1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#9156
organism: Homo sapiens

PhysicalInteraction [DCLRE1B -- Complex MUS81-EME1 {MUS81, EME1} ]
type: MolecularInteraction
xref: 18469862
participant: MUS81-EME1
participant: DCLRE1B

http://www.ncbi.nlm.nih.gov/#7486
type: UnificationXref
id: 7486
db: Entrez Gene

REV3L
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5980
organism: Homo sapiens

RPA1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6117
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#9400
type: UnificationXref
id: 9400
db: Entrez Gene

19596235
type: PublicationXref
id: 19596235
db: PubMed
title: Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair

HMGB1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3146
organism: Homo sapiens

PhysicalInteraction [FANCD2 -- PCNA ]
type: MolecularInteraction
xref: 19704162
participant: FANCD2
participant: PCNA

STRA13
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#201254
organism: Homo sapiens

17634560
type: PublicationXref
id: 17634560
db: PubMed
title: Polymorphic TP53BP1 and TP53 gene interactions associated with risk of squamous cell carcinoma of the head and neck

18848520
type: PublicationXref
id: 18848520
db: PubMed
title: SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint

WRN
type: Protein
entity reference: WRN

19270065
type: PublicationXref
id: 19270065
db: PubMed
title: MRE11 complex links RECQ5 helicase to sites of DNA damage

Ku heterodimer (Ku-70-ku-80) XRCC6-XRCC5
type: Complex
display name: Ku heterodimer (Ku-70-ku-80).complex
data source: Spike

WRN
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7486
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#79008
type: UnificationXref
id: 79008
db: Entrez Gene

CHEK2_inactive
type: Protein
entity reference: CHEK2

18082599
type: PublicationXref
id: 18082599
db: PubMed
title: The DNA damage response: ten years after

xeroderma pigmentosum protein A-replication protein A
type: Complex
display name: XPA-RPA.complex
component: RPA1
data source: Spike

CLSPN_inactive
type: Protein
entity reference: CLSPN

http://www.ncbi.nlm.nih.gov/#10721
type: UnificationXref
id: 10721
db: Entrez Gene

.RAD18.PROMOTES.RAD51C.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.RAD18.RAD51C
xref: 19396164
controller: RAD18
data source: Spike

CHEK1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1111
organism: Homo sapiens

20064461
type: PublicationXref
id: 20064461
db: PubMed
title: FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia

.Complex.RAD18.UBE2B..RAD18..PROMOTES.PCNA.
type: Catalysis
control type: ACTIVATION
controlled: Ubiquitination.P.RAD18.UBE2B.PCNA
xref: 20937699
xref: 10880451
xref: 19622405
controller: RAD18-UBE2B UBIQUITILATION COMPLEX
data source: Spike

http://www.ncbi.nlm.nih.gov/#22909
type: UnificationXref
id: 22909
db: Entrez Gene

EXO1
type: Protein
entity reference: EXO1

18769153
type: PublicationXref
id: 18769153
db: PubMed
title: Activation of ATR and related PIKKs

ATR
type: Protein
entity reference: ATR

SLX4
type: Protein
entity reference: SLX4

BLM, RPAs (1,2,3) FA and topoisomerase III alpha
type: Complex
display name: BRAFT.complex
component: FANCM
component: FANCE
component: BLM
component: RPA1
data source: Spike

19468048
type: PublicationXref
id: 19468048
db: PubMed
title: Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks

http://www.ncbi.nlm.nih.gov/#10459
type: UnificationXref
id: 10459
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#1196
type: UnificationXref
id: 1196
db: Entrez Gene

.ATM.PROMOTES.BRCA1.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.BRCA1
xref: 11278964
xref: 10550055
controller: ATM
data source: Spike

SLX4
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#84464
organism: Homo sapiens

SHPRH
type: Protein
entity reference: SHPRH

10880451
type: PublicationXref
id: 10880451
db: PubMed
title: Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair

http://www.ncbi.nlm.nih.gov/#6596
type: UnificationXref
id: 6596
db: Entrez Gene

.Complex.MRN..NBN..PROMOTES.RECQL5.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.MRN.RECQL5
xref: 19270065
controller: MRE11-RAD50-NBS1
data source: Spike

10448035
type: PublicationXref
id: 10448035
db: PubMed
title: Human Rad51 amino acid residues required for Rad52 binding

19995904
type: PublicationXref
id: 19995904
db: PubMed
title: DNA polymerase POLN participates in cross-link repair and homologous recombination

16789823
type: PublicationXref
id: 16789823
db: PubMed
title: Lysine 63-polyubiquitination guards against translesion synthesis-induced mutations

DCLRE1B
type: Protein
entity reference: DCLRE1B

http://www.ncbi.nlm.nih.gov/#7158
type: UnificationXref
id: 7158
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#2067
type: UnificationXref
id: 2067
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#7157
type: UnificationXref
id: 7157
db: Entrez Gene

.ATM.PROMOTES.H2AFX.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.H2AFX
xref: 18285803
xref: 16531125
controller: ATM
data source: Spike

PhysicalInteraction [MAD2L2 -- REV1 ]
type: MolecularInteraction
xref: 11485998
participant: REV1
participant: MAD2L2

PhysicalInteraction [PCNA -- REV1 ]
type: MolecularInteraction
xref: 20074045
participant: PCNA
participant: REV1
comment: Interaction between the BRCT domain of REV1 and and monoubiquitinated PCNA

TIMELESS
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8914
organism: Homo sapiens

PhysicalInteraction [RAD51 -- RAD51C ]
type: MolecularInteraction
xref: 15065660
xref: 16395335
xref: 12427746
participant: RAD51
participant: RAD51C

16633336
type: PublicationXref
id: 16633336
db: PubMed
title: Regulation of DNA repair by ubiquitylation

15314187
type: PublicationXref
id: 15314187
db: PubMed
title: The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair

7915517
type: PublicationXref
id: 7915517
db: PubMed
title: Transcriptional regulation of the PCNA promoter by p53

ATR
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#545
organism: Homo sapiens

16980608
type: PublicationXref
id: 16980608
db: PubMed
title: Functional analysis of p53 binding under differential stresses

POLA1
type: Protein
entity reference: POLA1

http://www.ncbi.nlm.nih.gov/#64858
type: UnificationXref
id: 64858
db: Entrez Gene

19279141
type: PublicationXref
id: 19279141
db: PubMed
title: The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM

.ATR.PROMOTES.POLN.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATR.POLN
xref: 21242293
controller: ATR
data source: Spike

18066086
type: PublicationXref
id: 18066086
db: PubMed
title: Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

http://www.ncbi.nlm.nih.gov/#9937
type: UnificationXref
id: 9937
db: Entrez Gene

SLX1A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#548593
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#2072
type: UnificationXref
id: 2072
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#11200
type: UnificationXref
id: 11200
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#11201
type: UnificationXref
id: 11201
db: Entrez Gene

FANCD2
type: Protein
entity reference: FANCD2

RAD52
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5893
organism: Homo sapiens

19157994
type: PublicationXref
id: 19157994
db: PubMed
title: Interaction with DNA polymerase eta is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells

19097996
type: PublicationXref
id: 19097996
db: PubMed
title: HCLK2 is required for activity of the DNA damage response kinase ATR

ATM
type: Protein
entity reference: ATM

16943440
type: PublicationXref
id: 16943440
db: PubMed
title: Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance

.FANCD2.PROMOTES.BLM.
type: Catalysis
control type: ACTIVATION
controlled: Methylation.P.FANCD2.BLM
xref: 19622405
controller: FANCD2
data source: Spike

.Complex.DNA.PK..PRKDC..PROMOTES.DCLRE1C.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.DNA.PK.DCLRE1C
xref: 14726021
controller: DNA-PK
data source: Spike

APITD1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#378708
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#8438
type: UnificationXref
id: 8438
db: Entrez Gene

DCLRE1C
type: Protein
entity reference: DCLRE1C

PCNA
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5111
organism: Homo sapiens

.USP1.INHIBITS.FANCI.
type: Catalysis
control type: INHIBITION
controlled: Deubiqitination.I.USP1.FANCI
xref: 17488615
controller: USP1
data source: Spike

15279790
type: PublicationXref
id: 15279790
db: PubMed
title: Claspin, a regulator of Chk1 in DNA replication stress pathway

HR Recombinase complex
type: Complex
display name: Recombinase.complex
component: RAD51
component: RAD52
component: RAD54L
data source: Spike

NBN
type: Protein
entity reference: NBN

http://www.ncbi.nlm.nih.gov/#672
type: UnificationXref
id: 672
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#675
type: UnificationXref
id: 675
db: Entrez Gene

15279789
type: PublicationXref
id: 15279789
db: PubMed
title: Chk1 in the DNA damage response: conserved roles from yeasts to mammals

TP53_inactive
type: Protein
entity reference: TP53

http://www.ncbi.nlm.nih.gov/#80198
type: UnificationXref
id: 80198
db: Entrez Gene

19622405
type: PublicationXref
id: 19622405
db: PubMed
title: The Fanconi anemia pathway: Insights from somatic cell genetics using DT40 cell line

CLSPN
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#63967
organism: Homo sapiens

RAD51
type: Protein
entity reference: RAD51

18931676
type: PublicationXref
id: 18931676
db: PubMed
title: FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway

SLX1A
type: Protein
entity reference: SLX1A

Homo sapiens
type: BioSource
xref: 9606

BRIP1_inactive
type: Protein
entity reference: BRIP1

DCLRE1B
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#64858
organism: Homo sapiens

18719106
type: PublicationXref
id: 18719106
db: PubMed
title: Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks

http://www.ncbi.nlm.nih.gov/#64421
type: UnificationXref
id: 64421
db: Entrez Gene

BRCA1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#672
organism: Homo sapiens

20159562
type: PublicationXref
id: 20159562
db: PubMed
title: BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control

16360315
type: PublicationXref
id: 16360315
db: PubMed
title: Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response

CLK2
type: Protein
entity reference: CLK2

FANCE_inactive
type: Protein
entity reference: FANCE

DCLRE1A
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#9937
organism: Homo sapiens

.CHEK1.PROMOTES.FANCD2.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.CHEK1.FANCD2
xref: 19861535
controller: CHEK1
data source: Spike

http://www.ncbi.nlm.nih.gov/#8914
type: UnificationXref
id: 8914
db: Entrez Gene

ERCC1-XPF(ERCC4)
type: Complex
display name: ERCC1-XPF(ERCC4).complex
component: ERCC4
component: ERCC1
data source: Spike

FANCM-C19orf40
type: Complex
display name: FANCM-FAAP24.complex
component: FANCM
data source: Spike

.ATM.INHIBITS.EXO1.
type: Catalysis
control type: INHIBITION
controlled: Phosphorylation.I.ATM.EXO1
xref: 20019063
controller: ATM
data source: Spike

http://www.ncbi.nlm.nih.gov/#5591
type: UnificationXref
id: 5591
db: Entrez Gene

PhysicalInteraction [BRCA2 -- RAD51 ]
type: MolecularInteraction
xref: 9560268
xref: 15703751
xref: 17541404
xref: 17145710
participant: BRCA2
participant: RAD51
comment: intact:EBI-987097,intact:EBI-987144,intact:EBI-987246,intact:EBI-987332,intact:EBI-987396,intact:EBI-297257,intact:EBI-297268,intact:EBI-297231,intact:EBI-298257,intact:EBI-298264

ERCC4
type: Protein
entity reference: ERCC4

TIPIN
type: Protein
entity reference: TIPIN

.TOPBP1.PROMOTES.ATR.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.TOPBP1.ATR
xref: 18066086
xref: 16285702
xref: 18769153
controller: TOPBP1
data source: Spike

PhysicalInteraction [DCLRE1A -- TP53BP1 ]
type: MolecularInteraction
xref: 18848520
participant: TP53BP1
participant: DCLRE1A

.TP53.PROMOTES.REV3L.
type: TemplateReactionRegulation
xref: 16980608
controller: TP53
control type: ACTIVATION
data source: Spike
controlled: Transcription.Regulation.P.TP53.REV3L

ERCC1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2067
organism: Homo sapiens

17145710
type: PublicationXref
id: 17145710
db: PubMed
title: IntAct--open source resource for molecular interaction data

16357213
type: PublicationXref
id: 16357213
db: PubMed
title: The Fanconi Anemia/BRCA pathway: new faces in the crowd

EME1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#146956
organism: Homo sapiens

17596542
type: PublicationXref
id: 17596542
db: PubMed
title: FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein

PhysicalInteraction [SLX4 -- SLX1A ]
type: MolecularInteraction
xref: 19596235
participant: SLX4
participant: SLX1A

9733515
type: PublicationXref
id: 9733515
db: PubMed
title: Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

9733514
type: PublicationXref
id: 9733514
db: PubMed
title: Enhanced phosphorylation of p53 by ATM in response to DNA damage

ATM
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#472
organism: Homo sapiens

19396164
type: PublicationXref
id: 19396164
db: PubMed
title: RAD18 transmits DNA damage signalling to elicit homologous recombination repair

RECQL5
type: Protein
entity reference: RECQL5

15468306
type: PublicationXref
id: 15468306
db: PubMed
title: Phosphorylation of Artemis following irradiation-induced DNA damage

19442256
type: PublicationXref
id: 19442256
db: PubMed
title: Understanding the functions of BRCA1 in the DNA-damage response

.FANCD2.PROMOTES.FAN1.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.FANCD2.FAN1
xref: 21331524
xref: 20603015
controller: FANCD2
data source: Spike

FAN1
type: Protein
entity reference: FAN1

RAD18-UBE2B.complex_inactive
type: Protein

http://www.ncbi.nlm.nih.gov/#641
type: UnificationXref
id: 641
db: Entrez Gene

APITD1_inactive
type: Protein
entity reference: APITD1

18451105
type: PublicationXref
id: 18451105
db: PubMed
title: Chk1 and Claspin potentiate PCNA ubiquitination

http://www.ncbi.nlm.nih.gov/#5980
type: UnificationXref
id: 5980
db: Entrez Gene

21464321
type: PublicationXref
id: 21464321
db: PubMed
title: Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway

.Complex.MRN..NBN..PROMOTES.ATM.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.MRN.ATM
xref: 18285803
xref: 18066086
controller: MRE11-RAD50-NBS1
data source: Spike

TOPBP1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#11073
organism: Homo sapiens

15272308
type: PublicationXref
id: 15272308
db: PubMed
title: Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism

CHEK1
type: Protein
entity reference: CHEK1

POLH_inactive
type: Protein
entity reference: POLH

POLK
type: Protein
entity reference: POLK

CHEK2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#11200
organism: Homo sapiens

PhysicalInteraction [HMGB1 -- Complex XPA-RPA {RPA1} ]
type: MolecularInteraction
xref: 19446504
participant: xeroderma pigmentosum protein A-replication protein A
participant: HMGB1

http://www.ncbi.nlm.nih.gov/#545
type: UnificationXref
id: 545
db: Entrez Gene

MRE11-RAD50-NBS1
type: Complex
display name: MRN.complex
component: NBN
data source: Spike

21242293
type: PublicationXref
id: 21242293
db: PubMed
title: ATR-mediated phosphorylation of DNA polymerase is needed for efficient recovery from UV damage

.TOPBP1.PROMOTES.POLA1.
type: Catalysis
control type: ACTIVATION
controlled: Other.P.TOPBP1.POLA1
xref: 19652550
controller: TOPBP1
data source: Spike

ATR-ATRIP.complex_inactive
type: Protein

FANC(A-B-C-E-F-G-L-M)
type: Complex
display name: FANC(A-B-C-E-F-G-L-M).complex
component: FANCM
component: FANCE
data source: Spike

.DCLRE1C.PROMOTES.Complex.NHEJ.secondary.complex...(XRCC4).
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.DCLRE1C.NHEJ.secondary.complex
xref: 16857680
controller: DCLRE1C
data source: Spike

TP53
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7157
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#5429
type: UnificationXref
id: 5429
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#5422
type: UnificationXref
id: 5422
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#5423
type: UnificationXref
id: 5423
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#79728
type: UnificationXref
id: 79728
db: Entrez Gene

11418864
type: PublicationXref
id: 11418864
db: PubMed
title: ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses

http://www.ncbi.nlm.nih.gov/#2178
type: UnificationXref
id: 2178
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#2177
type: UnificationXref
id: 2177
db: Entrez Gene

TP53BP1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7158
organism: Homo sapiens

.ATR.PROMOTES.FANCD2.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATR.FANCD2
xref: 16943440
controller: ATR
data source: Spike

REV1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#51455
organism: Homo sapiens

PCNA-RFC
type: Complex
display name: PCNA-RFC.complex
component: PCNA
data source: Spike

REV3L_inactive
type: Protein
entity reference: REV3L

PhysicalInteraction [FANCM -- Complex MHF {} ]
type: MolecularInteraction
xref: 20347418
xref: 20347429
participant: FANCM
participant: MHF1-MHF2 (APITD1 -STRA13)

.Complex.FANC(A.B.C.E.F.G.L.M)..FANCE,.FANCM..PROMOTES.REV1.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.FANC(A.B.C.E.F.G.L.M).REV1
xref: 19622405
controller: FANC(A-B-C-E-F-G-L-M)
data source: Spike

17296736
type: PublicationXref
id: 17296736
db: PubMed
title: Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway

TOPBP1_inactive
type: Protein
entity reference: TOPBP1

PhysicalInteraction [BRCA1 -- BRIP1 ]
type: MolecularInteraction
xref: 16713569
xref: 18369654
xref: 14576432
participant: BRCA1
participant: BRIP1

NBN
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#4683
organism: Homo sapiens

.ATM.PROMOTES.DCLRE1A.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.DCLRE1A
xref: 18848520
xref: 15456891
controller: ATM
data source: Spike

21331524
type: PublicationXref
id: 21331524
db: PubMed
title: Fanconi anemia: a disorder defective in the DNA damage response

16285702
type: PublicationXref
id: 16285702
db: PubMed
title: ATR-FT-IR membrane-based sensor for integrated microliquid-liquid extraction and detection

16357261
type: PublicationXref
id: 16357261
db: PubMed
title: Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis

12578958
type: PublicationXref
id: 12578958
db: PubMed
title: Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro

Spike
type: Provenance

15065660
type: PublicationXref
id: 15065660
db: PubMed
title: RAD51 localization and activation following DNA damage

PhysicalInteraction [SLX4 -- Complex MUS81-EME1 {MUS81, EME1} ]
type: MolecularInteraction
xref: 19596235
xref: 20658648
participant: SLX4
participant: MUS81-EME1

TIMELESS_inactive
type: Protein
entity reference: TIMELESS

FANCI_inactive
type: Protein
entity reference: FANCI

.PALB2.PROMOTES.BRCA2.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.PALB2.BRCA2
xref: 17200668
controller: PALB2
data source: Spike

RAD17
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5884
organism: Homo sapiens

DCLRE1A
type: Protein
entity reference: DCLRE1A

http://www.ncbi.nlm.nih.gov/#6117
type: UnificationXref
id: 6117
db: Entrez Gene

DCLRE1C_inactive
type: Protein
entity reference: DCLRE1C

USP1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#7398
organism: Homo sapiens

H2AFX
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#3014
organism: Homo sapiens

.CLSPN.PROMOTES.CHEK1.
type: Catalysis
control type: ACTIVATION
controlled: Other.P.CLSPN.CHEK1
xref: 15371427
xref: 15279790
xref: 18451105
controller: CLSPN
data source: Spike

.ATR.PROMOTES.FANCI.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATR.FANCI
xref: 18931676
controller: ATR
data source: Spike

DCLRE1A_inactive
type: Protein
entity reference: DCLRE1A

15743907
type: PublicationXref
id: 15743907
db: PubMed
title: ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation

POLQ
type: Protein
entity reference: POLQ

19806028
type: PublicationXref
id: 19806028
db: PubMed
title: DNA damage induced Pol eta recruitment takes place independently of the cell cycle phase

RAD51C_inactive
type: Protein
entity reference: RAD51C

FANCE
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2178
organism: Homo sapiens

HELQ
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#113510
organism: Homo sapiens

POLM
type: Protein
entity reference: POLM

http://www.ncbi.nlm.nih.gov/#5889
type: UnificationXref
id: 5889
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#5888
type: UnificationXref
id: 5888
db: Entrez Gene

20658648
type: PublicationXref
id: 20658648
db: PubMed
title: Multiple roles of ERCC1-XPF in mammalian interstrand crosslink repair

.CHEK1.PROMOTES.CLSPN.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.CHEK1.CLSPN
xref: 18451105
controller: CHEK1
data source: Spike

10660610
type: PublicationXref
id: 10660610
db: PubMed
title: A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2

REV1
type: Protein
entity reference: REV1

http://www.ncbi.nlm.nih.gov/#5884
type: UnificationXref
id: 5884
db: Entrez Gene

RECQL5
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#9400
organism: Homo sapiens

RAD17_inactive
type: Protein
entity reference: RAD17

911-complex.complex_inactive
type: Protein

http://www.ncbi.nlm.nih.gov/#63967
type: UnificationXref
id: 63967
db: Entrez Gene

11585903
type: PublicationXref
id: 11585903
db: PubMed
title: Physical and functional interactions of human DNA polymerase eta with PCNA

.ATM.PROMOTES.TP53.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.TP53
xref: 9733515
xref: 9733514
xref: 9843217
controller: ATM
data source: Spike

http://www.ncbi.nlm.nih.gov/#472
type: UnificationXref
id: 472
db: Entrez Gene

911
type: Complex
display name: 911-complex.complex
data source: Spike

.ATM.PROMOTES.DCLRE1C.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.DCLRE1C
xref: 15468306
xref: 15456891
controller: ATM
data source: Spike

http://www.ncbi.nlm.nih.gov/#146956
type: UnificationXref
id: 146956
db: Entrez Gene

.TP53.PROMOTES.PCNA.
type: TemplateReactionRegulation
xref: 7915517
controller: TP53
control type: ACTIVATION
data source: Spike
controlled: Transcription.Regulation.P.TP53.PCNA

DNA-PK
type: Complex
display name: DNA-PK.complex
component: PRKDC
data source: Spike

single stranded DNA
type: Complex
display name: ssDNA-RPA.complex
component: RPA1
data source: Spike

Gamma H2AX - MDC1
type: Complex
display name: Gamma H2AX - MDC1.complex
component: H2AFX
data source: Spike

.HLTF.INHIBITS.PCNA.
type: Catalysis
control type: INHIBITION
controlled: Ubiquitination.I.HLTF.PCNA
xref: 18719106
controller: HLTF
data source: Spike

12177300
type: PublicationXref
id: 12177300
db: PubMed
title: Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus

http://www.ncbi.nlm.nih.gov/#5932
type: UnificationXref
id: 5932
db: Entrez Gene

.ATM.PROMOTES.CHEK2.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.CHEK2
xref: 12773400
xref: 9889122
controller: ATM
data source: Spike

PhysicalInteraction [TP53 -- TP53BP1 ]
type: MolecularInteraction
xref: 16713569
xref: 17634560
participant: TP53BP1
participant: TP53

17963495
type: PublicationXref
id: 17963495
db: PubMed
title: Extensive ssDNA end formation at DNA double-strand breaks in non-homologous end-joining deficient cells during the S phase

RAD18
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#56852
organism: Homo sapiens

STRA13
type: Protein
entity reference: STRA13

http://www.ncbi.nlm.nih.gov/#4683
type: UnificationXref
id: 4683
db: Entrez Gene

20019063
type: PublicationXref
id: 20019063
db: PubMed
title: Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks

RPA1
type: Protein
entity reference: RPA1

MUS81-EME1
type: Complex
display name: MUS81-EME1.complex
component: EME1
component: MUS81
data source: Spike

PCNA_RNA
type: RnaRegion
entity reference: PCNA

19652550
type: PublicationXref
id: 19652550
db: PubMed
title: TopBP1 and DNA polymerase alpha-mediated recruitment of the 9-1-1 complex to stalled replication forks: implications for a replication restart-based mechanism for ATR checkpoint activation

.Complex.RPA..RPA1..PROMOTES.Complex.RAD18.UBE2B..RAD18.(RAD18).
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.RPA.RAD18.UBE2B
xref: 18342608
controller: Replication Protein A
data source: Spike

.CLK2.PROMOTES.ATR.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.CLK2.ATR
xref: 19097996
controller: CLK2
data source: Spike

POLQ
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#10721
organism: Homo sapiens

9889122
type: PublicationXref
id: 9889122
db: PubMed
title: A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

http://www.ncbi.nlm.nih.gov/#11073
type: UnificationXref
id: 11073
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#27434
type: UnificationXref
id: 27434
db: Entrez Gene

PCNA_inactive
type: Protein
entity reference: PCNA

POLN_inactive
type: Protein
entity reference: POLN

BRCA1
type: Protein
entity reference: BRCA1

POLH
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5429
organism: Homo sapiens

BLM
type: Protein
entity reference: BLM

.Complex.DNA.PK..PRKDC..PROMOTES.Complex.NHEJ.secondary.complex...(XRCC4).
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.DNA.PK.NHEJ.secondary.complex
xref: 14726021
controller: DNA-PK
data source: Spike

STRA13_inactive
type: Protein
entity reference: STRA13

18285803
type: PublicationXref
id: 18285803
db: PubMed
title: Regulation of DNA repair throughout the cell cycle

PhysicalInteraction [DCLRE1B -- Complex MRN {NBN} ]
type: MolecularInteraction
xref: 18469862
participant: MRE11-RAD50-NBS1
participant: DCLRE1B

SLX1B
type: Protein
entity reference: SLX1B

H2AFX_inactive
type: Protein
entity reference: H2AFX

.RAD52.PROMOTES.RAD51.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.RAD52.RAD51
xref: 10448035
controller: RAD52
data source: Spike

PRKDC_inactive
type: Protein
entity reference: PRKDC

http://www.ncbi.nlm.nih.gov/#257218
type: UnificationXref
id: 257218
db: Entrez Gene

TP53
type: Protein
entity reference: TP53

.ATR.PROMOTES.CHEK1.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATR.CHEK1
xref: 16431910
xref: 15279789
xref: 12766152
xref: 12781359
xref: 15190204
xref: 15272308
xref: 10859164
xref: 10859163
xref: 16360315
xref: 11090622
xref: 11390642
controller: ATR
data source: Spike

SLX1B
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#79008
organism: Homo sapiens

POLI_inactive
type: Protein
entity reference: POLI

.Complex.MRN..NBN..PROMOTES.RBBP8.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.MRN.RBBP8
xref: 17965729
controller: MRE11-RAD50-NBS1
data source: Spike

PhysicalInteraction [POLQ -- REV1 ]
type: MolecularInteraction
xref: 15189446
participant: POLQ
participant: REV1

REV1_inactive
type: Protein
entity reference: REV1

9811458
type: PublicationXref
id: 9811458
db: PubMed
title: Characterization of a carboxy-terminal BRCA1 interacting protein

RAD18-UBE2B UBIQUITILATION COMPLEX
type: Complex
display name: RAD18-UBE2B.complex
component: RAD18
data source: Spike

POLB
type: Protein
entity reference: POLB

USP1
type: Protein
entity reference: USP1

http://www.ncbi.nlm.nih.gov/#54962
type: UnificationXref
id: 54962
db: Entrez Gene

POLK
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#51426
organism: Homo sapiens

PhysicalInteraction [POLM -- REV1 ]
type: MolecularInteraction
xref: 15189446
participant: POLM
participant: REV1

.Complex.Ku.heterodimer.(Ku.70.ku.80)....PROMOTES.WRN.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.Ku.heterodimer.(Ku.70.ku.80).WRN
xref: 12919958
xref: 12177300
controller: Ku heterodimer (Ku-70-ku-80) XRCC6-XRCC5
data source: Spike

14576432
type: PublicationXref
id: 14576432
db: PubMed
title: BRCT repeats as phosphopeptide-binding modules involved in protein targeting

http://www.ncbi.nlm.nih.gov/#51455
type: UnificationXref
id: 51455
db: Entrez Gene

PhysicalInteraction [SLX4 -- SLX1B ]
type: MolecularInteraction
xref: 19596235
participant: SLX4
participant: SLX1B

HLTF
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#6596
organism: Homo sapiens

Bloom syndrome protein complex
type: Complex
display name: BLM complex.complex
component: BLM
component: RPA1
data source: Spike

18342608
type: PublicationXref
id: 18342608
db: PubMed
title: Activation of ubiquitin-dependent DNA damage bypass is mediated by replication protein a

.TIPIN.PROMOTES.TIMELESS.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.TIPIN.TIMELESS
xref: 17644383
controller: TIPIN
data source: Spike

.ATM.PROMOTES.RAD17.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.RAD17
xref: 11418864
xref: 11687627
controller: ATM
data source: Spike

POLB
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5423
organism: Homo sapiens

RAD54L
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#8438
organism: Homo sapiens

16713569
type: PublicationXref
id: 16713569
db: PubMed
title: A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration

.FANCD2.PROMOTES.SLX4.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.FANCD2.SLX4
xref: 21464321
controller: FANCD2
data source: Spike

RBBP8
type: Protein
entity reference: RBBP8

.Complex.911.complex....PROMOTES.TOPBP1.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.911.complex.TOPBP1
xref: 17636252
controller: 911
data source: Spike

PhysicalInteraction [DCLRE1B -- FANCD2 ]
type: MolecularInteraction
xref: 18469862
participant: FANCD2
participant: DCLRE1B

11390642
type: PublicationXref
id: 11390642
db: PubMed
title: ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

http://www.ncbi.nlm.nih.gov/#51426
type: UnificationXref
id: 51426
db: Entrez Gene

BRCA2
type: Protein
entity reference: BRCA2

XPC-HARD23B
type: Complex
display name: XPC-HRAD23B.complex
data source: Spike

11687627
type: PublicationXref
id: 11687627
db: PubMed
title: Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage

POLN
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#353497
organism: Homo sapiens

20937699
type: PublicationXref
id: 20937699
db: PubMed
title: RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network

EXO1_inactive
type: Protein
entity reference: EXO1

12773400
type: PublicationXref
id: 12773400
db: PubMed
title: A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein

.RPA1.PROMOTES.BRIP1.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.RPA1.BRIP1
xref: 19419957
xref: 17596542
controller: RPA1
data source: Spike

POLH
type: Protein
entity reference: POLH

12919958
type: PublicationXref
id: 12919958
db: PubMed
title: ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses

BLM_inactive
type: Protein
entity reference: BLM

FAN1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#22909
organism: Homo sapiens

.ATR.PROMOTES.RAD17.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATR.RAD17
xref: 11418864
controller: ATR
data source: Spike

17488615
type: PublicationXref
id: 17488615
db: PubMed
title: The Fanconi family adds a fraternal twin

.PCNA.PROMOTES.POLI.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.PCNA.POLI
xref: 16357261
controller: PCNA
data source: Spike

15189446
type: PublicationXref
id: 15189446
db: PubMed
title: Interaction of hREV1 with three human Y-family DNA polymerases

BRCA2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#675
organism: Homo sapiens

PhysicalInteraction [BRCA1 -- RBBP8 ]
type: MolecularInteraction
xref: 19442256
xref: 16713569
xref: 9811458
participant: BRCA1
participant: RBBP8

DCLRE1C
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#64421
organism: Homo sapiens

RAD51C
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5889
organism: Homo sapiens

REV3L_DNA
type: DnaRegion
entity reference: REV3L

.FANCM.PROMOTES.STRA13.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.FANCM.STRA13
xref: 20347428
controller: FANCM
data source: Spike

.Complex.RAD17.RFC..RAD17..PROMOTES.Complex.911.complex...(RAD9A).
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.RAD17.RFC.911.complex
xref: 12578958
controller: RAD17-RFC
data source: Spike

POLA1_inactive
type: Protein
entity reference: POLA1

http://www.ncbi.nlm.nih.gov/#5893
type: UnificationXref
id: 5893
db: Entrez Gene

.TOPBP1.PROMOTES.Complex.911.complex...(RAD9A).
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.TOPBP1.911.complex
xref: 19652550
controller: TOPBP1
data source: Spike

RBBP8
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5932
organism: Homo sapiens

TOPBP1
type: Protein
entity reference: TOPBP1

FANCD2_inactive
type: Protein
entity reference: FANCD2

.Complex.FANC(A.B.C.E.F.G.L.M)..FANCE,.FANCM..PROMOTES.FANCD2.
type: Catalysis
control type: ACTIVATION
controlled: Ubiquitination.P.FANC(A.B.C.E.F.G.L.M).FANCD2
xref: 16357213
controller: FANC(A-B-C-E-F-G-L-M)
data source: Spike

http://www.ncbi.nlm.nih.gov/#56852
type: UnificationXref
id: 56852
db: Entrez Gene

18369654
type: PublicationXref
id: 18369654
db: PubMed
title: Recognition of DNA double strand breaks by the BRCA1 tumor suppressor network

.FANCM.PROMOTES.BLM.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.FANCM.BLM
xref: 20064461
xref: 20347428
controller: FANCM
data source: Spike

POLA1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5422
organism: Homo sapiens

MUS81-EME1.complex_inactive
type: Protein

19446504
type: PublicationXref
id: 19446504
db: PubMed
title: Human HMGB1 directly facilitates interactions between nucleotide excision repair proteins on triplex-directed psoralen interstrand crosslinks

ATM_inactive
type: Protein
entity reference: ATM

BRIP1
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#83990
organism: Homo sapiens

17636252
type: PublicationXref
id: 17636252
db: PubMed
title: The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR

PhysicalInteraction [MAD2L2 -- REV3L ]
type: MolecularInteraction
xref: 10660610
participant: REV3L
participant: MAD2L2

TIMELESS
type: Protein
entity reference: TIMELESS

RAD51_inactive
type: Protein
entity reference: RAD51

16395335
type: PublicationXref
id: 16395335
db: PubMed
title: Interplay between human DNA repair proteins at a unique double-strand break in vivo

POLN
type: Protein
entity reference: POLN

12612651
type: PublicationXref
id: 12612651
db: PubMed
title: ATM and related protein kinases: safeguarding genome integrity

FANCD2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2177
organism: Homo sapiens

15703751
type: PublicationXref
id: 15703751
db: PubMed
title: The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction

.ATR.PROMOTES.H2AFX.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATR.H2AFX
xref: 12919958
controller: ATR
data source: Spike

17541404
type: PublicationXref
id: 17541404
db: PubMed
title: Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1

UIMCI-BRCA1-BARD1.complex_inactive
type: Protein

20603015
type: PublicationXref
id: 20603015
db: PubMed
title: Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2

BLM
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#641
organism: Homo sapiens

16431910
type: PublicationXref
id: 16431910
db: PubMed
title: Rapid activation of ATR by ionizing radiation requires ATM and Mre11

RAD18
type: Protein
entity reference: RAD18

15190204
type: PublicationXref
id: 15190204
db: PubMed
title: ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage

POLI
type: Protein
entity reference: POLI

BRCA1-PALB2-BRCA2
type: Complex
display name: BRCA1-PALB2-BRCA2.complex
component: BRCA1
component: PALB2
data source: Spike

FANCI/FANCD2
type: Complex
display name: FANCI/FANCD2.complex
component: FANCD2
component: FANCI
data source: Spike

CHEK1_inactive
type: Protein
entity reference: CHEK1

http://www.ncbi.nlm.nih.gov/#1111
type: UnificationXref
id: 1111
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#378708
type: UnificationXref
id: 378708
db: Entrez Gene

11090622
type: PublicationXref
id: 11090622
db: PubMed
title: Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts

10550055
type: PublicationXref
id: 10550055
db: PubMed
title: Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

.Complex.Ku.heterodimer.(Ku.70.ku.80)....PROMOTES.PRKDC.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.Ku.heterodimer.(Ku.70.ku.80).PRKDC
xref: 17963495
controller: Ku heterodimer (Ku-70-ku-80) XRCC6-XRCC5
data source: Spike

FANCE
type: Protein
entity reference: FANCE

NBN_inactive
type: Protein
entity reference: NBN

9606
type: UnificationXref
id: 9606
db: taxonomy

19861535
type: PublicationXref
id: 19861535
db: PubMed
title: Fanconi anemia complementation group FANCD2 protein serine 331 phosphorylation is important for fanconi anemia pathway function and BRCA2 interaction

POLB_inactive
type: Protein
entity reference: POLB

18469862
type: PublicationXref
id: 18469862
db: PubMed
title: Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links

RECQL5_inactive
type: Protein
entity reference: RECQL5

9560268
type: PublicationXref
id: 9560268
db: PubMed
title: The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment

http://www.ncbi.nlm.nih.gov/#55215
type: UnificationXref
id: 55215
db: Entrez Gene

RAD17
type: Protein
entity reference: RAD17

.Complex.ssDNA.RPA..ssDNA,.RPA1..PROMOTES.RAD17.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.ssDNA.RPA.RAD17
xref: 18082599
controller: single stranded DNA
data source: Spike

15456891
type: PublicationXref
id: 15456891
db: PubMed
title: Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response

HELQ
type: Protein
entity reference: HELQ

PRKDC
type: Protein
entity reference: PRKDC

HMGB1
type: Protein
entity reference: HMGB1

WRN_inactive
type: Protein
entity reference: WRN

17644383
type: PublicationXref
id: 17644383
db: PubMed
title: Circadian proteins in the regulation of cell cycle and genotoxic stress responses

BRCA1_inactive
type: Protein
entity reference: BRCA1

RAD17-RFC
type: Complex
display name: RAD17-RFC.complex
component: RAD17
data source: Spike

.SHPRH.INHIBITS.PCNA.
type: Catalysis
control type: INHIBITION
controlled: Ubiquitination.I.SHPRH.PCNA
xref: 16789823
xref: 18719106
controller: SHPRH
data source: Spike

RAD52
type: Protein
entity reference: RAD52

9843217
type: PublicationXref
id: 9843217
db: PubMed
title: ATM associates with and phosphorylates p53: mapping the region of interaction

FANCM
type: Protein
entity reference: FANCM

NHEJ secondary complex.complex_inactive
type: Protein

APITD1
type: Protein
entity reference: APITD1

Translation
type: MolecularInteraction
participant: REV3L_inactive
participant: REV3L_RNA

.FANCM.PROMOTES.APITD1.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.FANCM.APITD1
xref: 20347428
controller: FANCM
data source: Spike

12427746
type: PublicationXref
id: 12427746
db: PubMed
title: Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro

ATR-ATRIP [nucleoplasm]
type: Complex
display name: ATR-ATRIP.complex
component: ATR
data source: Spike

.TIMELESS.PROMOTES.TIPIN.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.TIMELESS.TIPIN
xref: 17644383
controller: TIMELESS
data source: Spike

16611994
type: PublicationXref
id: 16611994
db: PubMed
title: Rad18 regulates DNA polymerase kappa and is required for recovery from S-phase checkpoint-mediated arrest

.CHEK1.PROMOTES.FANCE.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.CHEK1.FANCE
xref: 17296736
controller: CHEK1
data source: Spike

FAN1_inactive
type: Protein
entity reference: FAN1

PCNA_DNA
type: DnaRegion
entity reference: PCNA

MHF1-MHF2 (APITD1 -STRA13)
type: Complex
display name: MHF.complex
data source: Spike

Replication Protein A
type: Complex
display name: RPA.complex
component: RPA1
data source: Spike

REV3L_RNA
type: RnaRegion
entity reference: REV3L

PALB2
type: Protein
entity reference: PALB2

RAD51C
type: Protein
entity reference: RAD51C

SHPRH
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#257218
organism: Homo sapiens

POLM
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#27434
organism: Homo sapiens

FANCD2-BRCA2
type: Complex
display name: FANCD2-BRCA2.complex
component: FANCD2
component: BRCA2
data source: Spike

.TOPBP1.PROMOTES.BRIP1.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.TOPBP1.BRIP1
xref: 20159562
controller: TOPBP1
data source: Spike

ERCC4
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#2072
organism: Homo sapiens

20347418
type: PublicationXref
id: 20347418
db: PubMed
title: Stabilizing and remodeling the blocked DNA replication fork: anchoring FANCM and the Fanconi anemia damage response

14726021
type: PublicationXref
id: 14726021
db: PubMed
title: Repair of DNA double strand breaks by non-homologous end joining

.RPA1.PROMOTES.Complex.ATR.ATRIP..ATR.(ATRIP).
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.RPA1.ATR.ATRIP
xref: 15743907
controller: RPA1
data source: Spike

PhysicalInteraction [CLK2 -- Complex FANCM-FAAP24 {FANCM} ]
type: MolecularInteraction
xref: 20064461
xref: 18995830
participant: FANCM-C19orf40
participant: CLK2

17965729
type: PublicationXref
id: 17965729
db: PubMed
title: Human CtIP promotes DNA end resection

.PCNA.PROMOTES.REV3L.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.PCNA.REV3L
xref: 19806028
controller: PCNA
data source: Spike

.USP1.INHIBITS.FANCD2.
type: Catalysis
control type: INHIBITION
controlled: Deubiqitination.I.USP1.FANCD2
xref: 16633336
controller: USP1
data source: Spike

CLK2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#1196
organism: Homo sapiens

11278964
type: PublicationXref
id: 11278964
db: PubMed
title: Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies

PCNA
type: Protein
entity reference: PCNA

.BRIP1.PROMOTES.TOPBP1.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.BRIP1.TOPBP1
xref: 20159562
controller: BRIP1
data source: Spike

20347429
type: PublicationXref
id: 20347429
db: PubMed
title: MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM

MUS81
type: Protein
entity reference: MUS81

20347428
type: PublicationXref
id: 20347428
db: PubMed
title: A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability

.POLH.PROMOTES.REV1.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.POLH.REV1
xref: 19157994
controller: POLH
data source: Spike

http://www.ncbi.nlm.nih.gov/#3014
type: UnificationXref
id: 3014
db: Entrez Gene

BRCA2_inactive
type: Protein
entity reference: BRCA2

ERCC1
type: Protein
entity reference: ERCC1

12781359
type: PublicationXref
id: 12781359
db: PubMed
title: Chk1 and Chk2 kinases in checkpoint control and cancer

PALB2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#79728
organism: Homo sapiens

20074045
type: PublicationXref
id: 20074045
db: PubMed
title: Ubiquitin-dependent regulation of translesion polymerases

ATR_inactive
type: Protein
entity reference: ATR

PhysicalInteraction [Complex MutS-beta complex {} -- Complex XPA-RPA {RPA1} ]
type: MolecularInteraction
xref: 19468048
participant: MSH2-MSH3
participant: xeroderma pigmentosum protein A-replication protein A

HLTF
type: Protein
entity reference: HLTF

.ATM.PROMOTES.TOPBP1.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.TOPBP1
xref: 19279141
controller: ATM
data source: Spike

RBBP8_inactive
type: Protein
entity reference: RBBP8

http://www.ncbi.nlm.nih.gov/#201254
type: UnificationXref
id: 201254
db: Entrez Gene

H2AFX
type: Protein
entity reference: H2AFX

RAD54L
type: Protein
entity reference: RAD54L

PhysicalInteraction [HELQ -- POLN ]
type: MolecularInteraction
xref: 19995904
participant: HELQ
participant: POLN

RAD51
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5888
organism: Homo sapiens

17200668
type: PublicationXref
id: 17200668
db: PubMed
title: PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

FANCI
type: Protein
entity reference: FANCI

.ATM.PROMOTES.FANCD2.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.FANCD2
xref: 12612651
controller: ATM
data source: Spike

PhysicalInteraction [HMGB1 -- Complex XPC-HRAD23B {} ]
type: MolecularInteraction
xref: 19446504
participant: XPC-HARD23B
participant: HMGB1

REV3L
type: Protein
entity reference: REV3L

FANCM
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#57697
organism: Homo sapiens

POLI
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#11201
organism: Homo sapiens

PRKDC
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#5591
organism: Homo sapiens

http://www.ncbi.nlm.nih.gov/#353497
type: UnificationXref
id: 353497
db: Entrez Gene

MAD2L2
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#10459
organism: Homo sapiens

16857680
type: PublicationXref
id: 16857680
db: PubMed
title: Interplay between Ku, artemis and DNA-PKcs at DNA ends

PhysicalInteraction [PCNA -- POLK ]
type: MolecularInteraction
xref: 16611994
participant: PCNA
participant: POLK

CHEK2
type: Protein
entity reference: CHEK2

MSH2-MSH3
type: Complex
display name: MutS-beta complex.complex
data source: Spike

EME1
type: Protein
entity reference: EME1

15371427
type: PublicationXref
id: 15371427
db: PubMed
title: Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1

NHEJ secondary complex
type: Complex
display name: NHEJ secondary complex.complex
data source: Spike

19419957
type: PublicationXref
id: 19419957
db: PubMed
title: FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by replication protein A to unwind the damaged DNA substrate in a strand-specific manner

BRIP1
type: Protein
entity reference: BRIP1

http://www.ncbi.nlm.nih.gov/#548593
type: UnificationXref
id: 548593
db: Entrez Gene

MUS81
type: ProteinReference
xref: http://www.ncbi.nlm.nih.gov/#80198
organism: Homo sapiens

SLX4_inactive
type: Protein
entity reference: SLX4

TIPIN_inactive
type: Protein
entity reference: TIPIN

12766152
type: PublicationXref
id: 12766152
db: PubMed
title: Human claspin is required for replication checkpoint control

.CHEK1.PROMOTES.RAD51.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.CHEK1.RAD51
xref: 18285803
controller: CHEK1
data source: Spike

19704162
type: PublicationXref
id: 19704162
db: PubMed
title: Functional interaction between the Fanconi Anemia D2 protein and proliferating cell nuclear antigen (PCNA) via a conserved putative PCNA interaction motif

19017809
type: PublicationXref
id: 19017809
db: PubMed
title: Human Rad54 protein stimulates human Mus81-Eme1 endonuclease

http://www.ncbi.nlm.nih.gov/#3146
type: UnificationXref
id: 3146
db: Entrez Gene

18995830
type: PublicationXref
id: 18995830
db: PubMed
title: FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex

16531125
type: PublicationXref
id: 16531125
db: PubMed
title: gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes

.Complex.PCNA.RFC..PCNA..PROMOTES.POLH.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.PCNA.RFC.POLH
xref: 11585903
controller: PCNA-RFC
data source: Spike

.Complex.911.complex....PROMOTES.POLB.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.911.complex.POLB
xref: 15314187
controller: 911
data source: Spike