Automatically obtained from Entrez Gene on 23-05-11PONTINTIP49ATIP49Pontin52ECP54INO80HNMP238TIH1RVB1Automatically obtained from Entrez Gene on 23-05-11OSRCRBp105-RbpRbpp110Automatically obtained from Entrez Gene on 23-05-11PIDMTA1L1DKFZp686F2281Automatically obtained from Entrez Gene on 23-05-11H3.4MGC126886MGC126888H3/gH3FTH3tAutomatically obtained from Entrez Gene on 23-05-11DKFZp781P2312Epl1Automatically obtained from Entrez Gene on 23-05-11YAPYAP2YKIYAP65Automatically obtained from Entrez Gene on 23-05-11PP2APTPAPR53MGC2184Automatically obtained from Entrez Gene on 23-05-11B56AMGC131915PR61AAutomatically obtained from Entrez Gene on 23-05-11PR61GMGC23064B56GAutomatically obtained from Entrez Gene on 23-05-11MGC8949B56DMGC2134Automatically obtained from Entrez Gene on 23-05-11HSAPGTBPHNPCC5Automatically obtained from Entrez Gene on 23-05-11HSORC1PARC1ORC1LAutomatically obtained from Entrez Gene on 23-05-11NURF55RBAP48Automatically obtained from Entrez Gene on 23-05-11ORC2LAutomatically obtained from Entrez Gene on 23-05-11ORC4PORC4LFLJ46668Automatically obtained from Entrez Gene on 23-05-11ORC5TORC5PORC5LAutomatically obtained from Entrez Gene on 23-05-11DKFZp781H1753SA2SA-2DKFZp686P168bA517O1.1FLJ25871Automatically obtained from Entrez Gene on 23-05-11RIMCTIPSAE2Automatically obtained from Entrez Gene on 23-05-11MGC2731SOSS-B1hSSB1SSB1Automatically obtained from Entrez Gene on 23-05-11MGC138868RbAp46MGC138867Automatically obtained from Entrez Gene on 23-05-11HD2YAF1RPD3Automatically obtained from Entrez Gene on 23-05-11STAF40TR-APPAF400FLJ10671Tra1PAF350/400Automatically obtained from Entrez Gene on 23-05-11HIRS-1Automatically obtained from Entrez Gene on 23-05-11YL-1YL1CFL1Swc2TCFL1Automatically obtained from Entrez Gene on 23-05-11MGC4854MGC12816MGC4242HMG-RHMGIYHMGA1AAutomatically obtained from Entrez Gene on 23-05-11HD1RPD3L1GON-10DKFZp686H12203RPD3Automatically obtained from Entrez Gene on 23-05-11FLJ11543DNMTAP1KIAA1425EAF2SWC4DKFZp686L09142MEAF2DNMAP1Automatically obtained from Entrez Gene on 23-05-11RBBP3RBAP1RBP3E2F-1Automatically obtained from Entrez Gene on 23-05-11FLJ42994JFY1PUMAAutomatically obtained from Entrez Gene on 23-05-11TIP60TIPcPLA2PLIPHTATIP1ESA1HTATIPAutomatically obtained from Entrez Gene on 23-05-11PP2CARP-CPP2CalphaPP2AcAutomatically obtained from Entrez Gene on 23-05-11FZRHCDH1HCDHFZR2KIAA1242CDH1CDC20CAutomatically obtained from Entrez Gene on 23-05-11DDIT1GADD45Automatically obtained from Entrez Gene on 23-05-11DKFZp434D1026FLJ12870DKFZp781N1478Automatically obtained from Entrez Gene on 23-05-11CKIICK2A1Automatically obtained from Entrez Gene on 23-05-11MGC131615MGC131613MGC131612Automatically obtained from Entrez Gene on 23-05-11MGC9527DKFZp434B027FLJ22477FBX14pp2386MGC15419DKFZp434J1815Fbx31FBXO14Automatically obtained from Entrez Gene on 23-05-11G5ACK2NMGC138224MGC138222CSK2BCK2BAutomatically obtained from Entrez Gene on 23-05-11KIAA9001D6S113ERNF3NATFSHDKFZp686N0336RING3FLJ31942FSRG1Automatically obtained from Entrez Gene on 23-05-11Automatically obtained from Entrez Gene on 23-05-11CHK1Automatically obtained from Entrez Gene on 23-05-11CNA43MGC126776DNA43Automatically obtained from Entrez Gene on 23-05-11APRNOXAAutomatically obtained from Entrez Gene on 23-05-11KIAA1515Automatically obtained from Entrez Gene on 23-05-11TIP49BREPTININO80JRVB2ECP51TIP48TIH2Automatically obtained from Entrez Gene on 23-05-11PHAS-I4EBP14E-BP1MGC4316BP-1Automatically obtained from Entrez Gene on 23-05-11PDCD12Automatically obtained from Entrez Gene on 23-05-11Mi2-BETAMi-2bDKFZp686E06161Automatically obtained from Entrez Gene on 23-05-11MGC8367Automatically obtained from Entrez Gene on 23-05-11CTC75KU70CTCBFML8G22P1TLAAAutomatically obtained from Entrez Gene on 23-05-11MGC131997MGC148092MGC8560p97IBMPFDTERAAutomatically obtained from Entrez Gene on 23-05-11CAGH32DKFZP434I225P400TNRC12FLJ45115FLJ42018Automatically obtained from Entrez Gene on 23-05-11ZFHMi2-ALPHAMi-2aAutomatically obtained from Entrez Gene on 23-05-11RNF96KAP1TF1BTIF1BFLJ29029Automatically obtained from Entrez Gene on 23-05-11IKBEAutomatically obtained from Entrez Gene on 23-05-11NFKBIMAD-3IKBAAutomatically obtained from Entrez Gene on 23-05-11TRIP9IKBBAutomatically obtained from Entrez Gene on 23-05-11MTDPS8BMTDPS8ADKFZp686M05248MGC42116P53R2MGC102856Automatically obtained from Entrez Gene on 23-05-11KIAA1794FLJ10719Automatically obtained from Entrez Gene on 23-05-11PKB-ALPHAPKBAKTRAC-ALPHAPRKBARACMGC99656Automatically obtained from Entrez Gene on 23-05-11TONEBPOREBPKIAA0827NFATZNF-AT5NFATL1Automatically obtained from Entrez Gene on 23-05-11RIPFLJ39204RIP1Automatically obtained from Entrez Gene on 23-05-11HARAKIRIDP5Automatically obtained from Entrez Gene on 23-05-11Automatically obtained from Entrez Gene on 23-05-11HYRCDNA-PKcsp350HYRC1XRCC7DNAPKDNPK1Automatically obtained from Entrez Gene on 23-05-11KIAA0170NFBD1MGC166888DKFZp781A0122Automatically obtained from Entrez Gene on 23-05-11RAD24CCYCR24LFLJ41520RAD17SPHRAD17Automatically obtained from Entrez Gene on 23-05-11RAD9Automatically obtained from Entrez Gene on 23-05-11hHR21MCD1SCC1HR21FLJ40596NXP1FLJ25655HRAD21KIAA0078Automatically obtained from Entrez Gene on 23-05-11LKB1PJSAutomatically obtained from Entrez Gene on 23-05-11KRS1FLJ90748MST2Automatically obtained from Entrez Gene on 23-05-11MGC5276RFC38Automatically obtained from Entrez Gene on 23-05-11A1RFC40MGC3665Automatically obtained from Entrez Gene on 23-05-11RFC36MGC1155Automatically obtained from Entrez Gene on 23-05-11A1MGC27291RFC37Automatically obtained from Entrez Gene on 23-05-11Automatically obtained from Entrez Gene on 23-05-11A-SCIDFLJ11360SCIDAFLJ36438hSNM1CSNM1CRS-SCIDDCLREC1CAutomatically obtained from Entrez Gene on 23-05-11FLJ23711PRO0593DKFZp686K02111Automatically obtained from Entrez Gene on 23-05-11SCA-1CPP32CPP32BAutomatically obtained from Entrez Gene on 23-05-11hExoIHEX1Automatically obtained from Entrez Gene on 23-05-11CASPASE-9cAPAF-3ICE-LAP6APAF3MCH6Automatically obtained from Entrez Gene on 23-05-11mir-181cMIRN181CAutomatically obtained from Entrez Gene on 23-05-11gC1qRgC1Q-RSF2p32GC1QBPp32HABP1Automatically obtained from Entrez Gene on 23-05-11MIRN181AMIRN181A2hsa-mir-181a-2Automatically obtained from Entrez Gene on 23-05-11MIRN181B1Automatically obtained from Entrez Gene on 23-05-11MIRN181B2Automatically obtained from Entrez Gene on 23-05-11KIAA1987MUS312BTBD12KIAA1784FANCPAutomatically obtained from Entrez Gene on 23-05-11IkappaBNSMGC11314TA-NFKBHMGC149503Automatically obtained from Entrez Gene on 23-05-11HNGS1MRE11BATLDMRE11Automatically obtained from Entrez Gene on 23-05-11SNM1PSO2SNM1AKIAA0086Automatically obtained from Entrez Gene on 23-05-11FLJ12847MCTBRIT1Automatically obtained from Entrez Gene on 23-05-11C321D2.2C321D2.3C16orf41C321D2.4CHL12Ctf18RUVBLAutomatically obtained from Entrez Gene on 23-05-11BCL2L8BBC2Automatically obtained from Entrez Gene on 23-05-11hRad50NBSLDRAD502Automatically obtained from Entrez Gene on 23-05-11NFKBIKBFLJ33771FLJ40509FLJ36218IKKBFLJ38368IKK2MGC131801IKK-betaAutomatically obtained from Entrez Gene on 23-05-11GemRP3-369A17.3Automatically obtained from Entrez Gene on 23-05-11MGC138285KIAA1150P66betaRP11-216N14.6MGC138257FLJ37346Automatically obtained from Entrez Gene on 23-05-11KG1TH3-K9-HMTase4ESETKIAA0067KMT1EAutomatically obtained from Entrez Gene on 23-05-11BCL2L4Automatically obtained from Entrez Gene on 23-05-11MGC3887BAKBCL2L7BAK-LIKEMGC117255CDN1Automatically obtained from Entrez Gene on 23-05-11FLJ10416COP1RNF200Automatically obtained from Entrez Gene on 23-05-11REC1HRAD1Automatically obtained from Entrez Gene on 23-05-11IKBZFLJ30225INAPMAILFLJ34463Automatically obtained from Entrez Gene on 23-05-11HPOT1DKFZp586D211Automatically obtained from Entrez Gene on 23-05-11CDC25Automatically obtained from Entrez Gene on 23-05-11ORC6LAutomatically obtained from Entrez Gene on 23-05-11LATORC3LLATHEOAutomatically obtained from Entrez Gene on 23-05-11MPFDNEM3NEM2NEM1CFTD1ASMACFTDCFTDMACTAAutomatically obtained from Entrez Gene on 23-05-11IKK-gammaIP2IP1AMCBX1IPNEMOFIP-3Fip3pFIP3IPD2Automatically obtained from Entrez Gene on 23-05-11DKFZp586O0821NY-CO-41DMTaseAutomatically obtained from Entrez Gene on 23-05-11M31HP1Hs-betaCBXMOD1HP1HsbetaHP1-BETAp25betaAutomatically obtained from Entrez Gene on 23-05-11CDC54MGC33310P1-CDC21hCdc21CDC21Automatically obtained from Entrez Gene on 23-05-11PARPADPRTpADPRT-1ADPRT1PARP-1ADPRT 1PPOLAutomatically obtained from Entrez Gene on 23-05-11URCC4MRG15BPFLJ10914MRGBPEaf7Automatically obtained from Entrez Gene on 23-05-11p300KAT3BRSTS2Automatically obtained from Entrez Gene on 23-05-11Automatically obtained from Entrez Gene on 23-05-11KIAA0030cdc19CDCL1MITOTINCCNL1D3S3194BM28MGC10606Automatically obtained from Entrez Gene on 23-05-11KIAA1266Automatically obtained from Entrez Gene on 23-05-11P1-MCM3HCC5P1.hMGC1157RLFBAutomatically obtained from Entrez Gene on 23-05-11MGC9284CREBAutomatically obtained from Entrez Gene on 23-05-11DKFZp686L20222P34CDC2MGC111195CDC2CDC28AAutomatically obtained from Entrez Gene on 23-05-11SA1DKFZp781D1416Automatically obtained from Entrez Gene on 23-05-11NIP3Automatically obtained from Entrez Gene on 23-05-11DKFZp547P028SHEP1p528KIAA0393jdf2D15F37S1Automatically obtained from Entrez Gene on 23-05-11CDC18LHsCDC18HsCDC6Automatically obtained from Entrez Gene on 23-05-11mir-213MIRN181A1hsa-mir-181a-1MIRN213MIR213Automatically obtained from Entrez Gene on 23-05-11MRG15MORFRG15S863-6Eaf3MGC10631MEAF3HsT17725Automatically obtained from Entrez Gene on 23-05-11KIAA0406Automatically obtained from Entrez Gene on 23-05-11MGC104252FLJ11090Automatically obtained from Entrez Gene on 23-05-11CUT23APC8ANAPC8Automatically obtained from Entrez Gene on 23-05-11hMLH1FCC2COCA2HNPCCMGC5172HNPCC2Automatically obtained from Entrez Gene on 23-05-11PP1425CHK2HuCds1LFS2CDS1RAD53Automatically obtained from Entrez Gene on 23-05-11FLJ46894pNORF1FLJ43809HUPF1KIAA0221NORF1RENT1Automatically obtained from Entrez Gene on 23-05-11PSSALREAutomatically obtained from Entrez Gene on 23-05-11p33(CDK2)Automatically obtained from Entrez Gene on 23-05-11LIPOHMGI-CSTQTL9HMGICBABLAutomatically obtained from Entrez Gene on 23-05-11ATDCTELO1ATCATDATEAT1TEL1ATAMGC74674DKFZp781A0353Automatically obtained from Entrez Gene on 23-05-11GSBTPS2DP3DP2.5DP2Automatically obtained from Entrez Gene on 23-05-11BRCC1RNF53BROVCA1BRCAIIRISPSCPPNCA4Automatically obtained from Entrez Gene on 23-05-11PO-GAA1RECC1RFC140MHCBFBMGC51786RFCAutomatically obtained from Entrez Gene on 23-05-11hsa-mir-421MIRN421Automatically obtained from Entrez Gene on 23-05-11SIAH1AFLJ08065Automatically obtained from Entrez Gene on 23-05-11FLJ00065Automatically obtained from Entrez Gene on 23-05-11P18AIMP3Automatically obtained from Entrez Gene on 23-05-11INO80KARPN-BETAArp4BAF53AACTL6MGC5382Automatically obtained from Entrez Gene on 23-05-11EWS-ATF1FUS/ATF-1TREB36Automatically obtained from Entrez Gene on 23-05-11SMAP2p120SMAPAutomatically obtained from Entrez Gene on 23-05-11123F2NORE2AREH3P21RDA32RASSF1AAutomatically obtained from Entrez Gene on 23-05-11WDR79FLJ10385TCAB1Automatically obtained from Entrez Gene on 23-05-11CED4APAF-1DKFZp781B1145Automatically obtained from Entrez Gene on 23-05-11CAF-1CAF1P60CAF1CAF1AMPP7MPHOSPH7CAF-IP60Automatically obtained from Entrez Gene on 23-05-11p150ABLc-ABLv-ablJTK7bcr/ablAutomatically obtained from Entrez Gene on 23-05-11CCNACCN1Automatically obtained from Entrez Gene on 23-05-11TRTEST2hEST2TCS1TP2Automatically obtained from Entrez Gene on 23-05-11FLJ10155MGC87362NBS1NBSATVAT-V2P95AT-V1Automatically obtained from Entrez Gene on 23-05-11CCNEAutomatically obtained from Entrez Gene on 23-05-11hTRF1-ASFLJ41416TRF1t-TRF1TRBF1TRFPIN2Automatically obtained from Entrez Gene on 23-05-11TRF2TRBF2Automatically obtained from Entrez Gene on 23-05-11TROVE1TLP1TP1p240VAULT2Automatically obtained from Entrez Gene on 23-05-11SCARNA19hTRTRC3TRAutomatically obtained from Entrez Gene on 23-05-11BimLBAMBIM-beta7BimELBIM-alpha6BIMBODBIM-beta6Automatically obtained from Entrez Gene on 23-05-11HP1-GAMMAHECHHP1Hs-gammaAutomatically obtained from Entrez Gene on 23-05-11p66alphaFLJ21017FLJ20085Automatically obtained from Entrez Gene on 23-05-11NOLA4NAP57DKCCBF5FLJ97620XAP101Automatically obtained from Entrez Gene on 23-05-11DRIP5RAP1Automatically obtained from Entrez Gene on 23-05-11TIN2Automatically obtained from Entrez Gene on 23-05-11HP1AHP1Automatically obtained from Entrez Gene on 23-05-11REPA3Automatically obtained from Entrez Gene on 23-05-11RNF85MGC:3310Automatically obtained from Entrez Gene on 23-05-11RPA32REPA2Automatically obtained from Entrez Gene on 23-05-11RPA70RP-AMST075HSSBREPA1RF-AAutomatically obtained from Entrez Gene on 23-05-11P21p21CIP1SDI1MDA-6CAP20WAF1CIP1CDKN1Automatically obtained from Entrez Gene on 23-05-11CAF1P150P150CAF-1MGC71229CAF1BCAF1Automatically obtained from Entrez Gene on 23-05-11ASFSF2p33MGC5228SRp30aFLJ53078SF2SFRS1Automatically obtained from Entrez Gene on 23-05-11PIP1TPP1TINT1PTOPAutomatically obtained from Entrez Gene on 23-05-11PCA1MGC118792MGC118793DEPC-1DEPC1MGC118790ABH3FLJ43614Automatically obtained from Entrez Gene on 23-05-11H2A/XH2A.XH2AXAutomatically obtained from Entrez Gene on 23-05-11P73Automatically obtained from Entrez Gene on 23-05-11CRE-BP1CREB2TREB7HB16MGC111558Automatically obtained from Entrez Gene on 23-05-11HDMXDKFZp781B1423MGC132766MDMXMRP1Automatically obtained from Entrez Gene on 23-05-11MGC5370HDMXhdm2MGC71221Automatically obtained from Entrez Gene on 23-05-11FLJ54767KIAA1052Automatically obtained from Entrez Gene on 23-05-11STPK13PLKAutomatically obtained from Entrez Gene on 23-05-11hHUS1Automatically obtained from Entrez Gene on 23-05-11BAMCSPG6CDLS3BMHSMC3L1HCAPAutomatically obtained from Entrez Gene on 23-05-11PT-WDMAWDUNRIPAutomatically obtained from Entrez Gene on 23-05-11GAS41B230215M10Rik4930573H17RikYAF9NUBI-1Automatically obtained from Entrez Gene on 23-05-11APAKFLJ32191Automatically obtained from Entrez Gene on 23-05-11BIP1BP4NBKAutomatically obtained from Entrez Gene on 23-05-11CLK2KIAA0683FLJ10924TEL2DKFZp434A073Automatically obtained from Entrez Gene on 23-05-11FP497MGC42355MGC15319Automatically obtained from Entrez Gene on 23-05-11MGC125976Automatically obtained from Entrez Gene on 23-05-11LCFS2HNPCCHNPCC1FCC1COCA1Automatically obtained from Entrez Gene on 23-05-11P1-CDC46MGC5315CDC46Automatically obtained from Entrez Gene on 23-05-11MCG40308P105MCMMis5Automatically obtained from Entrez Gene on 23-05-11RECQL3MGC131618BSRECQ2MGC131620MGC126616RECQL2Automatically obtained from Entrez Gene on 23-05-11NFKBIKAIKK1IKKAIKK-alphaTCF16IKBKAAutomatically obtained from Entrez Gene on 23-05-11wtsWARTSAutomatically obtained from Entrez Gene on 23-05-11Automatically obtained from Entrez Gene on 23-05-11P85MCMP1.1-MCM3CDC47PNAS146MCM2P1CDC47Automatically obtained from Entrez Gene on 23-05-11FANCDFA4FA-D2FAD2DKFZp762A223FADFLJ23826FACDAutomatically obtained from Entrez Gene on 23-05-11DXS423ESMC1alphaSMC1L1SB1.8CDLS2SMCBSMC1KIAA0178DKFZp686L19178MGC138332Automatically obtained from Entrez Gene on 23-05-11MGC138366p20253BP1FLJ41424Automatically obtained from Entrez Gene on 23-05-11ING2Eaf4p47ING3FLJ20089MEAF4Automatically obtained from Entrez Gene on 23-05-11TRP53FLJ92943P53LFS1TTI1 and TTI2 (C8orf41) exist in multiple complexes, including a 2-MDa complex with TEL2 (telomeremaintenance 2), called the Triple T complex, and phosphoinositide-3-kinase-related protein kinases (PIKKs) such
as ataxia telangiectasia-mutated (ATM).includes:NFkB1 (p105/p50) and NFkB2 (p100/p52)histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histonesMaster regulator of G1/S phase of the cell cycleAPC/C is a multi-subunit cullin-RING E3 ubiquitin ligase that regulates progression through the mitotic phase of the cell cycle and controls entry into S phase by catalysing the ubiquitylation of cyclins and other cell cycle regulatory proteins.holoenzyme generated by the tight association of two ? or ?' catalytic subunits with a dimer of ? regulatory subunits Litchfield D.W. et al. (2003) Biochem J. 369: 1-15involved in the recognition and repair of aberrant DNA structures. BASC, a super complex of BRCA1 associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev. 2000 Apr 15;14(8):927-39.IKK complex phosphorylates IkB, the NFkB inhibitor family
seminars in IMMUNOLOGY 12:85-98. (2000)RECREUTE TO dsbPCNA is loaded to the DNA by RFC in DNA replication, and in NERRad1, Rad9, Hus1 - Sliding clamp checkpointNFkB heterodimerThe complex functions in DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ).Involved in acetylation of taget proteins during DNA damage response
Mol Cell. 2006 21:51-64
also in; Current Opinion in Genetics and Development Volume 14, Issue 2, April 2004, Pages 147-154
The NuA4 histone acetyltransferase (HAT) multisubunit complex is responsible for acetylation of histone H4 and H2A N-terminal tails in yeast. The NuA4/Tip60 HAT complex is highly conserved in eukaryotes playing primary roles in transcription, cellular response to DNA damage, and cell cycle control. ING subunits are probably crucial for acetylation of chromatin substrates.
At anaphase onset, the APC/C requires the activator protein CDC20 to target securin and cyclin B1 for proteasome-dependent degradation, but then depends on the CDC20-related protein FZR1 (also known as CDH1) to remain active until the onset of the next S phaseThe origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins.Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. In somatic and germ cells This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the complex is thought to be an important part of functional kinetochores.BH3 pro-apoptotic family- antagonist of the BCL-2 familymini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro PNAS February 18, 2003 vol. 100 no. 4 1633?1638The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also called activator 1, is a protein complex consisting of five distinct subunits of 145, 40, 38, 37, and 36.5 kD. Human replication protein A (RPA) is a single-stranded DNA-binding protein that is composed of subunits of 70, 32, and 14 kDa. This heterotrimeric complex is required for multiple processes in DNA metabolism including DNA replication, DNA repair, and recombination.Involved in recruitment of pol epsilon
PMID: 20227374 Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat.three members have been identified: alpha, betta. GammaTHE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 284, NO. 24, pp. 16061-16065, June 12, 2009RAP1 is TERF2IP
telomere protection is mediated by a RAP1/TRF2 complex
Mol Cell. 2007 May 11;26(3):323-34.S111Thr21Ser 535Akt is phosphorylated on S473.relaxation of chromatine after DNA damageGeminin inhibits Cdt1 that promotes replication licensingNeuronsData from dephosphorylation assays and reduced activation of MST1/2 seen after RASSF1A depletion suggest that dephosphorylation of MST1/2 on Thr-183 and Thr-180 by PP2A is prevented by RASSF1A,S403Phosphorylation of HP1-b on amino acid Thr 51 accompanies mobilization, releasing HP1-b from chromatin by disrupting hydrogen bonds that fold its chromodomain around H3K9me.Phosphorylation of CDC6 by CycA-CDK2 is required for it relocalization from the nucleuous to the cytoplasm in the transition from G1 to S.TERF1 is Pin2 Ser219.S635, S645Phosphorylation on Mdm2-Ser395Homolog of Mice gene Btbd12 ID 52864Phosphorylation on p53-Ser20Ser15Ser 216Chek2 = Cds1Reported by David Chen in the ATW05. DNA-PKcs is phosphorylated on T2609 and S2056.There might be other kinases that involve in NFAT5 (TONEBP/OREBP) activationSer272RBBP8 is CtIPAt the beginning of this reaction, 1 molecule of 'ATP', and 1 molecule of 'Chk2' are present. At the end of this reaction, 1 molecule of 'phospho-Chk2', and 1 molecule of 'ADP' are present.<br><br>This reaction takes place in the 'nucleus' and is mediated by the 'kinase activity' of 'phospho-ATM (Ser 1981)'.<br>Generated from Reactome catalysis kinase_activity_of_phospho_ATM__Ser_1981___nucleoplasm_3 and reaction Phosphorylation and activation of CHK2 by ATM(Phosphorylation_and_activation_of_CHK2_by_ATM)intact:EBI-764866