The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression
Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A
ATM-dependent phosphorylation and accumulation of endogenous BLM protein in response to ionizing radiation
Regulation of telomerase by telomeric proteins
The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals
Polymorphic TP53BP1 and TP53 gene interactions associated with risk of squamous cell carcinoma of the head and neck
ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage
Early events in the mammalian response to DNA double-strand breaks
Differential regulation of the p21/WAF-1 and mdm2 genes after high-dose UV irradiation: p53-dependent and p53-independent regulation of the mdm2 gene
The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair
Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner
Identification of phosphorylation sites on transcription factor Sp1 in response to DNA damage and its accumulation at damaged sites
Activation and regulation of ATM kinase activity in response to DNA double-strand breaks
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization
Gadd45a contributes to p53 stabilization in response to DNA damage
Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly
A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression
Stress-specific response of the p53-Mdm2 feedback loop
The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation
Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1
HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents
Identification of the mismatch repair genes PMS2 and MLH1 as p53 target genes by using serial analysis of binding elements
Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage
Phosphorylation of Artemis following irradiation-induced DNA damage
ATM Regulates a RASSF1A-Dependent DNA Damage Response
Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation
Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase
Plk1 promotes nuclear translocation of human Cdc25C during prophase
DNA-activated protein kinase functions in a newly observed S phase checkpoint that links histone mRNA abundance with DNA replication
The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2
Distinct BRCT domains in Mcph1/Brit1 mediate ionizing radiation-induced focus formation and centrosomal localization
Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM
Identification of p32 as a novel substrate for ATM in heart
PUMA mediates the apoptotic response to p53 in colorectal cancer cells
DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity
Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21
Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling - roles of p53, p73 and HIPK2
Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression
DNA damage-induced MDMX degradation is mediated by MDM2
Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint
Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks
RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein
Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366
Aven-dependent activation of ATM following DNA damage
Conserved and distinct modes of CREB/ATF transcription factor regulation by PP2A/B56gamma and genotoxic stress
Cell differentiation induces TIF1beta association with centromeric heterochromatin via an HP1 interaction
Valosin-containing protein phosphorylation at Ser784 in response to DNA damage
PhysicalInteraction [ATM -- Complex TTT {} ]
Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage
A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein
ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses
The C terminus of p53 binds the N-terminal domain of MDM2
ARF-dependent regulation of ATM and p53 associated KZNF (Apak) protein activity in response to oncogenic stress
Regulation of intra-S phase checkpoint by ionizing radiation (IR)-dependent and IR-independent phosphorylation of SMC3
Phosphorylation of p300 by ATM controls the stability of NBS1
Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK
ATM and related protein kinases: safeguarding genome integrity
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks
COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas
ATM associates with and phosphorylates p53: mapping the region of interaction
Expression of p53R2, newly p53 target in oral normal epithelium, epithelial dysplasia and squamous cell carcinoma.
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins
ATM-mediated phosphorylation activates the tumor-suppressive function of B56-PP2A
Repair of DNA double strand breaks by non-homologous end joining
Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies
A comprehensive modular map of molecular interactions in RB/E2F pathway
Profiling of UV-induced ATM/ATR signaling pathways
A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability
DNA damage-induced phosphorylation of the human telomere-associated protein TRF2
setdb1: a novel kap-1 associated hustone h3, lysin 9 specific methyltransferasethat contributes to hp1 mediated silencing of euchromatic genes by krab zinc finger proteins
Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit
Interplay between Ku, artemis and DNA-PKcs at DNA ends
ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP
Phosphorylation of Sp1 in response to DNA damage by ataxia telangiectasia-mutated kinase
Importance of PIKKs in NF-B activation by genotoxic stress
F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage
ATM is down-regulated by N-Myc-regulated microRNA-421
A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response
p21(Waf1/Cip1) inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption
A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-B activation
Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1
Efficient activation of p53 pathway in A549 cells exposed to L2, a novel compound targeting p53-MDM2 interaction
DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1
Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair
Transforming growth factor- regulates the sphere-initiating stem cell-like feature in breast cancer through miRNA-181 and ATM
SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint
The DNA damage response: ten years after
Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response
The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM
Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1
SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1
Insulin-like growth factor-1 attenuates cisplatin-induced gammaH2AX formation and DNA double-strand breaks repair pathway in non-small cell lung cancer
Anaphase promoting complex / FZR1(CDH1) activator
PUMA, a novel proapoptotic gene, is induced by p53
Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death
Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break
Claspin, a regulator of Chk1 in DNA replication stress pathway
Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD.
Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin
Identification of target genes for EWS/ATF-1 chimeric transcription factor
Tumor suppressor LATS1 is a negative regulator of oncogene YAP
Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c
The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
IntAct--open source resource for molecular interaction data
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
Enhanced phosphorylation of p53 by ATM in response to DNA damage
Chk1 and Claspin potentiate PCNA ubiquitination
PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites
Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases
Investigation of the proapoptotic BCL-2 family member bid on the crossroad of the DNA damage response and apoptosis
Transcriptional control of human p53-regulated genes
Pro-proliferative FoxM1 is a target of p53-mediated repression
Ataxia telangiectasia-mutated, a DNA damage-inducible kinase, contributes to high NaCl-induced nuclear localization of transcription factor TonEBP/OREBP
APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis
ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses
CyclinB-Cdc2 (CDK1)- M-phase-promoting factor (MPF)
Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro
ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation
Expression analysis using DNA microarrays demonstrates that E2F-1 up-regulates expression of DNA replication genes including replication protein A2
Physical and functional interaction between the Bloom's syndrome gene product and the largest subunit of chromatin assembly factor 1
ATM-dependent phosphorylation of ATF2 is required for the DNA damage response
The p53 pathway: positive and negative feedback loops
The anaphase-promoting complex: a key factor in the regulation of cell cycle
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
Suppression of lipopolysaccharide-induced nuclear factor-kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages
Highly potent p21(WAF1)-derived peptide inhibitors of CDK-mediated pRb phosphorylation: delineation and structural insight into their interactions with cyclin A
Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis
Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli
Regulation of DNA repair throughout the cell cycle
Gadd45a, a p53- and BRCA1-regulated stress protein, in cellular response to DNA damage
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage
Homeodomain-Interacting Protein Kinase 2 Is the Ionizing Radiation-Activated p53 Serine 46 Kinase and Is Regulated by ATM
Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress
A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM
Tel2 regulates the stability of PI3K-related protein kinases
The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01
p21/CDKN1A mediates negative regulation of transcription by p53
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
Proapoptotic BID is an ATM effector in the DNA-damage response
A role for proapoptotic BID in the DNA-damage response
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
BID regulation by p53 contributes to chemosensitivity
HMGA1 protein is a novel target of the ATM kinase
The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA
Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage
Regulation of early events in chromosome replication
Chromosome end maintenance by telomerase
Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM
Apaf-1 is a transcriptional target for E2F and p53
HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes
Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks
Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response
Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase
Binding to the naturally occurring double p53 binding site of the Mdm2 promoter alleviates the requirement for p53 C-terminal activation
Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex
Dose-dependent mutual regulation between Wip1 and p53 following UVC irradiation
p53 status correlates with the differential expression of the DNA mismatch repair protein MSH2 in non-small cell lung carcinoma
ATM and Chk2 kinase target the p53 cofactor Strap
Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition
S1219 residue of 53BP1 is phosphorylated by ATM kinase upon DNA damage and required for proper execution of DNA damage response
Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1
Dancing on damaged chromatin: functions of ATM and the RAD50/MRE11/NBS1 complex in cellular responses to DNA damage
gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes