9738006
type: PublicationXref
db: PubMed
id: 9738006
title: The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression

.ATM.PROMOTES.IKBKG.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.IKBKG
controller: ATM
xref: 16497931
data source: Spike

MDM4_inactive
type: Protein
entity reference: MDM4

ZNF420
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#147923

SETDB1
type: Protein
entity reference: SETDB1

http://www.ncbi.nlm.nih.gov/#84464
type: UnificationXref
db: Entrez Gene
id: 84464

15510216
type: PublicationXref
db: PubMed
id: 15510216
title: Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A

CDKN1A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1026

CAF-1.complex_inactive
type: Protein

NFAT5_inactive
type: Protein
entity reference: NFAT5

CLSPN
type: Protein
entity reference: CLSPN

11146546
type: PublicationXref
db: PubMed
id: 11146546
title: ATM-dependent phosphorylation and accumulation of endogenous BLM protein in response to ionizing radiation

.ATM.PROMOTES.STK11.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.STK11
controller: ATM
xref: 12234250
data source: Spike

http://www.ncbi.nlm.nih.gov/#9156
type: UnificationXref
db: Entrez Gene
id: 9156

CREB1
type: Protein
entity reference: CREB1

EXO1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9156

http://www.ncbi.nlm.nih.gov/#10725
type: UnificationXref
db: Entrez Gene
id: 10725

HERC2
type: Protein
entity reference: HERC2

http://www.ncbi.nlm.nih.gov/#79035
type: UnificationXref
db: Entrez Gene
id: 79035

15189140
type: PublicationXref
db: PubMed
id: 15189140
title: Regulation of telomerase by telomeric proteins

12814430
type: PublicationXref
db: PubMed
id: 12814430
title: The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer

SMC3
type: Protein
entity reference: SMC3

16427009
type: PublicationXref
db: PubMed
id: 16427009
title: MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals

STRAP
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#11171

YAP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#10413

Lig_IV - XRCC4.complex_inactive
type: Protein

http://www.ncbi.nlm.nih.gov/#2033
type: UnificationXref
db: Entrez Gene
id: 2033

EP300
type: Protein
entity reference: EP300

RIPK1
type: Protein
entity reference: RIPK1

17634560
type: PublicationXref
db: PubMed
id: 17634560
title: Polymorphic TP53BP1 and TP53 gene interactions associated with risk of squamous cell carcinoma of the head and neck

APAF1_RNA
type: RnaRegion
entity reference: APAF1

.ATM.PROMOTES.BLM.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.BLM
controller: ATM
xref: 12034743
xref: 11146546
data source: Spike

pre_RC.complex_inactive
type: Protein

19015526
type: PublicationXref
db: PubMed
id: 19015526
title: ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage

FBXO31
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#79791

.ATM.PROMOTES.E2F1.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.E2F1
controller: ATM
xref: 11459832
data source: Spike

http://www.ncbi.nlm.nih.gov/#693122
type: UnificationXref
db: Entrez Gene
id: 693122

PPP2R5C_inactive
type: Protein
entity reference: PPP2R5C

http://www.ncbi.nlm.nih.gov/#79648
type: UnificationXref
db: Entrez Gene
id: 79648

.PPP2CA.INHIBITS.ATM.
type: Catalysis
control type: INHIBITION
controlled: Dephosphorylation.I.PPP2CA.ATM
controller: PPP2CA
xref: 15510216
data source: Spike

EXO1
type: Protein
entity reference: EXO1

APC/C-FZR1.complex_inactive
type: Protein

SLX4
type: Protein
entity reference: SLX4

MDM4
type: Protein
entity reference: MDM4

.Complex.PP2A....INHIBITS.ATM.
type: Catalysis
control type: INHIBITION
controlled: Dephosphorylation.I.PP2A.ATM
controller: PP2A.complex
xref: 15510216
data source: Spike

.ATM.PROMOTES.BRCA1.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.BRCA1
controller: ATM
xref: 11278964
xref: 10550055
data source: Spike

http://www.ncbi.nlm.nih.gov/#55183
type: UnificationXref
db: Entrez Gene
id: 55183

SLX4
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#84464

.TP53.PROMOTES.MSH2.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.TP53.MSH2
controller: TP53
xref: 12209975
data source: Spike

18644834
type: PublicationXref
db: PubMed
id: 18644834
title: Early events in the mammalian response to DNA double-strand breaks

.TRIM28.UNKNOWN.SETDB1.
type: Catalysis
control type: ACTIVATION_UNKMECH
controlled: Physical.Interaction.U.TRIM28.SETDB1
controller: TRIM28
xref: 11959841
data source: Spike

.ATM.INHIBITS.MDM4.
type: Catalysis
control type: INHIBITION
controlled: Phosphorylation.I.ATM.MDM4
controller: ATM
xref: 15788536
data source: Spike

OBFC2B
type: Protein
entity reference: OBFC2B

Translation
type: MolecularInteraction
participant: RPA2_RNA
participant: RPA2_inactive

SMC1A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8243

.ATM.PROMOTES.H2AFX.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.H2AFX
controller: ATM
xref: 18285803
xref: 16531125
data source: Spike

http://www.ncbi.nlm.nih.gov/#9113
type: UnificationXref
db: Entrez Gene
id: 9113

BID
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#637

http://www.ncbi.nlm.nih.gov/#1869
type: UnificationXref
db: Entrez Gene
id: 1869

MIR421
type: Protein
entity reference: MIR421

.ATM.PROMOTES.NFAT5.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.NFAT5
controller: ATM
xref: 15840767
xref: 15173573
data source: Spike

9260156
type: PublicationXref
db: PubMed
id: 9260156
title: Differential regulation of the p21/WAF-1 and mdm2 genes after high-dose UV irradiation: p53-dependent and p53-independent regulation of the mdm2 gene

15314187
type: PublicationXref
db: PubMed
id: 15314187
title: The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair

RPA2_DNA
type: DnaRegion
entity reference: RPA2

.ATM.PROMOTES.CEP164.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.CEP164
controller: ATM
xref: 18283122
data source: Spike

NFAT5
type: Protein
entity reference: NFAT5

.Complex.RAD17.RFC..RAD17..PROMOTES.Complex.911.complex..HUS1.(RAD9A).
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.RAD17.RFC.911.complex
controller: RAD17-RFC.complex
xref: 12578958
data source: Spike

GADD45A_DNA
type: DnaRegion
entity reference: GADD45A

.MDM4.INHIBITS.TP53.
type: Catalysis
control type: INHIBITION
controlled: Physical.Interaction.I.MDM4.TP53
controller: MDM4
xref: 12963717
data source: Spike

CBX1
type: Protein
entity reference: CBX1

9922454
type: PublicationXref
db: PubMed
id: 9922454
title: Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

.TELO2.PROMOTES.ATM.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.TELO2.ATM
controller: TELO2
xref: 18160036
data source: Spike

BAX
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#581

.TRIM28.INHIBITS.BBC3.
type: TemplateReactionRegulation
control type: INHIBITION
controlled: Transcription.Regulation.I.TRIM28.BBC3
controller: TRIM28
xref: 17942393
data source: Spike

MDM2_RNA
type: RnaRegion
entity reference: MDM2

18619531
type: PublicationXref
db: PubMed
id: 18619531
title: Identification of phosphorylation sites on transcription factor Sp1 in response to DNA damage and its accumulation at damaged sites

http://www.ncbi.nlm.nih.gov/#9126
type: UnificationXref
db: Entrez Gene
id: 9126

18066086
type: PublicationXref
db: PubMed
id: 18066086
title: Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

9889196
type: PublicationXref
db: PubMed
id: 9889196
title: Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization

http://www.ncbi.nlm.nih.gov/#11200
type: UnificationXref
db: Entrez Gene
id: 11200

FANCD2
type: Protein
entity reference: FANCD2

.Complex.CK2....PROMOTES.CBX1.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.CK2.CBX1
controller: CK2.complex
xref: 18438399
data source: Spike

.ATM.PROMOTES.SLX4.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.SLX4
controller: ATM
xref: 17525332
xref: 21655083
data source: Spike

14627995
type: PublicationXref
db: PubMed
id: 14627995
title: Gadd45a contributes to p53 stabilization in response to DNA damage

20427287
type: PublicationXref
db: PubMed
id: 20427287
title: Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly

CBX1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#10951

.TP53.PROMOTES.BID.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.TP53.BID
controller: TP53
xref: 12402042
xref: 18431400
data source: Spike

PCNA
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5111

MRE11A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4361

11340163
type: PublicationXref
db: PubMed
id: 11340163
title: A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression

NBN
type: Protein
entity reference: NBN

20624280
type: PublicationXref
db: PubMed
id: 20624280
title: Stress-specific response of the p53-Mdm2 feedback loop

STK11
type: Protein
entity reference: STK11

http://www.ncbi.nlm.nih.gov/#10951
type: UnificationXref
db: Entrez Gene
id: 10951

.TP53.PROMOTES.MLH1.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.TP53.MLH1
controller: TP53
xref: 15781865
data source: Spike

http://www.ncbi.nlm.nih.gov/#672
type: UnificationXref
db: Entrez Gene
id: 672

STK11_inactive
type: Protein
entity reference: STK11

ATF2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1386

TP53_inactive
type: Protein
entity reference: TP53

PMAIP1_RNA
type: RnaRegion
entity reference: PMAIP1

RFWD2
type: Protein
entity reference: RFWD2

Translation
type: MolecularInteraction
participant: BID_RNA
participant: BID_inactive

CDC25C
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#995

C1QBP
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#708

PPP2CA
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5515

12654725
type: PublicationXref
db: PubMed
id: 12654725
title: The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation

BRCA1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#672

UPF1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5976

18283122
type: PublicationXref
db: PubMed
id: 18283122
title: Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1

TERF2_inactive
type: Protein
entity reference: TERF2

PPP2R5D_inactive
type: Protein
entity reference: PPP2R5D

http://www.ncbi.nlm.nih.gov/#207
type: UnificationXref
db: Entrez Gene
id: 207

21339738
type: PublicationXref
db: PubMed
id: 21339738
title: HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents

.CDKN1A.INHIBITS.Complex.CycE.Cdk2...(CDK2).
type: Catalysis
control type: INHIBITION
controlled: Physical.Interaction.I.CDKN1A.CycE.Cdk2
controller: CDKN1A
xref: 9858545
data source: Spike

SMC1A_inactive
type: Protein
entity reference: SMC1A

.ATM.INHIBITS.EXO1.
type: Catalysis
control type: INHIBITION
controlled: Phosphorylation.I.ATM.EXO1
controller: ATM
xref: 20019063
data source: Spike

15781865
type: PublicationXref
db: PubMed
id: 15781865
title: Identification of the mismatch repair genes PMS2 and MLH1 as p53 target genes by using serial analysis of binding elements

http://www.ncbi.nlm.nih.gov/#9675
type: UnificationXref
db: Entrez Gene
id: 9675

PPP2R5D
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5528

ATF2_inactive
type: Protein
entity reference: ATF2

12861053
type: PublicationXref
db: PubMed
id: 12861053
title: Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage

SIAH1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6477

http://www.ncbi.nlm.nih.gov/#9869
type: UnificationXref
db: Entrez Gene
id: 9869

BAX_RNA
type: RnaRegion
entity reference: BAX

ATM
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#472

15468306
type: PublicationXref
db: PubMed
id: 15468306
title: Phosphorylation of Artemis following irradiation-induced DNA damage

.TP53.PROMOTES.BAX.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.TP53.BAX
controller: TP53
xref: 7834749
data source: Spike

http://www.ncbi.nlm.nih.gov/#842
type: UnificationXref
db: Entrez Gene
id: 842

http://www.ncbi.nlm.nih.gov/#637
type: UnificationXref
db: Entrez Gene
id: 637

RPA2_inactive
type: Protein
entity reference: RPA2

IKBKG
type: Protein
entity reference: IKBKG

MCM3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4172

.TP53.PROMOTES.RRM2B.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.TP53.RRM2B
controller: TP53
xref: 12565178
data source: Spike

19962312
type: PublicationXref
db: PubMed
id: 19962312
title: ATM Regulates a RASSF1A-Dependent DNA Damage Response

http://www.ncbi.nlm.nih.gov/#836
type: UnificationXref
db: Entrez Gene
id: 836

http://www.ncbi.nlm.nih.gov/#641
type: UnificationXref
db: Entrez Gene
id: 641

Translation
type: MolecularInteraction
participant: ATM_RNA
participant: ATM_inactive

.ATM.PROMOTES.USP28.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.USP28
controller: ATM
xref: 16901786
data source: Spike

TDP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#55775

http://www.ncbi.nlm.nih.gov/#7415
type: UnificationXref
db: Entrez Gene
id: 7415

11459832
type: PublicationXref
db: PubMed
id: 11459832
title: Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation

http://www.ncbi.nlm.nih.gov/#10524
type: UnificationXref
db: Entrez Gene
id: 10524

UPF1_inactive
type: Protein
entity reference: UPF1

CHEK1
type: Protein
entity reference: CHEK1

.CASP9.PROMOTES.CASP3.
type: Catalysis
control type: ACTIVATION
controlled: Proteolytic.Processing.P.CASP9.CASP3
controller: CASP9
xref: 9390557
data source: Spike

PPP2R5C
type: Protein
entity reference: PPP2R5C

.ATM.PROMOTES.RIF1.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.RIF1
controller: ATM
xref: 18077418
xref: 15342490
data source: Spike

15163406
type: PublicationXref
db: PubMed
id: 15163406
title: Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase

.AVEN.PROMOTES.ATM.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.AVEN.ATM
controller: AVEN
xref: 18571408
data source: Spike

http://www.ncbi.nlm.nih.gov/#9656
type: UnificationXref
db: Entrez Gene
id: 9656

USP28
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#57646

TP73_inactive
type: Protein
entity reference: TP73

TP53
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7157

MSH2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4436

11897663
type: PublicationXref
db: PubMed
id: 11897663
title: Plk1 promotes nuclear translocation of human Cdc25C during prophase

HMGA2
type: Protein
entity reference: HMGA2

http://www.ncbi.nlm.nih.gov/#5423
type: UnificationXref
db: Entrez Gene
id: 5423

18158334
type: PublicationXref
db: PubMed
id: 18158334
title: DNA-activated protein kinase functions in a newly observed S phase checkpoint that links histone mRNA abundance with DNA replication

FBXO31
type: Protein
entity reference: FBXO31

YAP1
type: Protein
entity reference: YAP1

21199877
type: PublicationXref
db: PubMed
id: 21199877
title: The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2

17599047
type: PublicationXref
db: PubMed
id: 17599047
title: Distinct BRCT domains in Mcph1/Brit1 mediate ionizing radiation-induced focus formation and centrosomal localization

http://www.ncbi.nlm.nih.gov/#6794
type: UnificationXref
db: Entrez Gene
id: 6794

http://www.ncbi.nlm.nih.gov/#8517
type: UnificationXref
db: Entrez Gene
id: 8517

RASSF1_inactive
type: Protein
entity reference: RASSF1

15546863
type: PublicationXref
db: PubMed
id: 15546863
title: Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM

http://www.ncbi.nlm.nih.gov/#4171
type: UnificationXref
db: Entrez Gene
id: 4171

http://www.ncbi.nlm.nih.gov/#4172
type: UnificationXref
db: Entrez Gene
id: 4172

18070599
type: PublicationXref
db: PubMed
id: 18070599
title: Identification of p32 as a novel substrate for ATM in heart

NBN
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4683

TERF2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7014

SRSF1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6426

11709054
type: PublicationXref
db: PubMed
id: 11709054
title: Mechanisms of p53-dependent apoptosis

12574499
type: PublicationXref
db: PubMed
id: 12574499
title: PUMA mediates the apoptotic response to p53 in colorectal cancer cells

http://www.ncbi.nlm.nih.gov/#6788
type: UnificationXref
db: Entrez Gene
id: 6788

.TP53BP1.PROMOTES.TP53.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.TP53BP1.TP53
controller: TP53BP1
xref: 17634560
data source: Spike

.STK3.PROMOTES.LATS1.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.STK3.LATS1
controller: STK3
xref: 15688006
data source: Spike

17923702
type: PublicationXref
db: PubMed
id: 17923702
title: DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity

DCLRE1A
type: Protein
entity reference: DCLRE1A

14872059
type: PublicationXref
db: PubMed
id: 14872059
title: Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21

http://www.ncbi.nlm.nih.gov/#6118
type: UnificationXref
db: Entrez Gene
id: 6118

http://www.ncbi.nlm.nih.gov/#466
type: UnificationXref
db: Entrez Gene
id: 466

.ATM.PROMOTES.RRM2B.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.RRM2B
controller: ATM
xref: 19015526
data source: Spike

.CLSPN.PROMOTES.CHEK1.
type: Catalysis
control type: ACTIVATION
controlled: Other.P.CLSPN.CHEK1
controller: CLSPN
xref: 15371427
xref: 15279790
xref: 18451105
data source: Spike

DCLRE1A_inactive
type: Protein
entity reference: DCLRE1A

http://www.ncbi.nlm.nih.gov/#5883
type: UnificationXref
db: Entrez Gene
id: 5883

IKBKG
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8517

CycE-Cdk2.complex
type: Complex
name: Cyclin E - CDK2
data source: Spike

http://www.ncbi.nlm.nih.gov/#5884
type: UnificationXref
db: Entrez Gene
id: 5884

EEF1E1
type: Protein
entity reference: EEF1E1

RAD17_inactive
type: Protein
entity reference: RAD17

http://www.ncbi.nlm.nih.gov/#4193
type: UnificationXref
db: Entrez Gene
id: 4193

MDM2
type: Protein
entity reference: MDM2

.TP53.PROMOTES.CDKN1A.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.TP53.CDKN1A
controller: TP53
xref: 12748190
xref: 21163364
xref: 19749794
data source: Spike

http://www.ncbi.nlm.nih.gov/#4194
type: UnificationXref
db: Entrez Gene
id: 4194

http://www.ncbi.nlm.nih.gov/#63967
type: UnificationXref
db: Entrez Gene
id: 63967

19788416
type: PublicationXref
db: PubMed
id: 19788416
title: Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling - roles of p53, p73 and HIPK2

.ATM.PROMOTES.TP53.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.TP53
controller: ATM
xref: 9733515
xref: 9733514
xref: 9843217
data source: Spike

911-complex.complex
type: Complex
component: HUS1
name: 911
data source: Spike

http://www.ncbi.nlm.nih.gov/#472
type: UnificationXref
db: Entrez Gene
id: 472

17942393
type: PublicationXref
db: PubMed
id: 17942393
title: Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression

CAF-1.complex
type: Complex
name: chromatin assembly factor 1
data source: Spike

pre_RC.complex
type: Complex
component: MCM2
component: CDC6
component: MCM3
name: pre_Replication Complex
data source: Spike

12963717
type: PublicationXref
db: PubMed
id: 12963717
title: DNA damage-induced MDMX degradation is mediated by MDM2

http://www.ncbi.nlm.nih.gov/#9894
type: UnificationXref
db: Entrez Gene
id: 9894

.TRIM28.UNKNOWN.CHD3.
type: Catalysis
control type: ACTIVATION_UNKMECH
controlled: Physical.Interaction.U.TRIM28.CHD3
controller: TRIM28
xref: 11230151
data source: Spike

SP1_inactive
type: Protein
entity reference: SP1

HMGA2_inactive
type: Protein
entity reference: HMGA2

http://www.ncbi.nlm.nih.gov/#3667
type: UnificationXref
db: Entrez Gene
id: 3667

http://www.ncbi.nlm.nih.gov/#1647
type: UnificationXref
db: Entrez Gene
id: 1647

15342490
type: PublicationXref
db: PubMed
id: 15342490
title: Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint

BH3 fam.family
type: Protein
member physical entity: BBC3
member physical entity: BID
member physical entity: PMAIP1
xref: TAU:F.000016
data source: Spike

RIF1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#55183

TDP1_inactive
type: Protein
entity reference: TDP1

LATS1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9113

MCM2
type: Protein
entity reference: MCM2

.Complex.NuA4....PROMOTES.ATM.
type: Catalysis
control type: ACTIVATION
controlled: Acetylation.P.NuA4.ATM
controller: NuA4.complex
xref: 17923702
data source: Spike

.H2AFX.PROMOTES.MDC1.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.H2AFX.MDC1
controller: H2AFX
xref: 16427009
data source: Spike

.ATM.PROMOTES.CHEK2.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.CHEK2
controller: ATM
xref: 12773400
xref: 9889122
data source: Spike

PMAIP1_DNA
type: DnaRegion
entity reference: PMAIP1

.ATM.PROMOTES.SMC1A.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.SMC1A
controller: ATM
xref: 11877376
data source: Spike

CycA-Cdk2.complex_inactive
type: Protein

http://www.ncbi.nlm.nih.gov/#4683
type: UnificationXref
db: Entrez Gene
id: 4683

20019063
type: PublicationXref
db: PubMed
id: 20019063
title: Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks

ZNF420
type: Protein
entity reference: ZNF420

http://www.ncbi.nlm.nih.gov/#8924
type: UnificationXref
db: Entrez Gene
id: 8924

17889669
type: PublicationXref
db: PubMed
id: 17889669
title: RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein

HIPK2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#28996

http://www.ncbi.nlm.nih.gov/#8737
type: UnificationXref
db: Entrez Gene
id: 8737

CREB1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1385

BLM
type: Protein
entity reference: BLM

12234250
type: PublicationXref
db: PubMed
id: 12234250
title: Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366

CDKN1A_DNA
type: DnaRegion
entity reference: CDKN1A

18571408
type: PublicationXref
db: PubMed
id: 18571408
title: Aven-dependent activation of ATM following DNA damage

H2AFX_inactive
type: Protein
entity reference: H2AFX

OBFC2B_inactive
type: Protein
entity reference: OBFC2B

HIPK2
type: Protein
entity reference: HIPK2

PRKDC_inactive
type: Protein
entity reference: PRKDC

MLH1
type: Protein
entity reference: MLH1

MCM3
type: Protein
entity reference: MCM3

SMC3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9126

20730097
type: PublicationXref
db: PubMed
id: 20730097
title: Conserved and distinct modes of CREB/ATF transcription factor regulation by PP2A/B56gamma and genotoxic stress

.YAP1.PROMOTES.TP73.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.YAP1.TP73
controller: YAP1
xref: 17889669
xref: 19788416
data source: Spike

http://www.ncbi.nlm.nih.gov/#22897
type: UnificationXref
db: Entrez Gene
id: 22897

IRS1
type: Protein
entity reference: IRS1

12154074
type: PublicationXref
db: PubMed
id: 12154074
title: Cell differentiation induces TIF1beta association with centromeric heterochromatin via an HP1 interaction

.TRIM28.INHIBITS.CDKN1A.
type: TemplateReactionRegulation
control type: INHIBITION
controlled: Transcription.Regulation.I.TRIM28.CDKN1A
controller: TRIM28
xref: 17942393
data source: Spike

http://www.ncbi.nlm.nih.gov/#5515
type: UnificationXref
db: Entrez Gene
id: 5515

Translation
type: MolecularInteraction
participant: BBC3
participant: BBC3_RNA

RFWD2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#64326

.Complex.DNA.PK..PRKDC..PROMOTES.Complex.Lig IV...XRCC4...(LIG4).
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.DNA.PK.Lig IV...XRCC4
controller: DNA-PK.complex
xref: 15194694
data source: Spike

CHD3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1107

16140914
type: PublicationXref
db: PubMed
id: 16140914
title: Valosin-containing protein phosphorylation at Ser784 in response to DNA damage

http://www.ncbi.nlm.nih.gov/#27113
type: UnificationXref
db: Entrez Gene
id: 27113

.ATM.PROMOTES.RAD17.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.RAD17
controller: ATM
xref: 11418864
xref: 11687627
data source: Spike

http://www.ncbi.nlm.nih.gov/#5528
type: UnificationXref
db: Entrez Gene
id: 5528

http://www.ncbi.nlm.nih.gov/#5527
type: UnificationXref
db: Entrez Gene
id: 5527

PhysicalInteraction [ATM -- Complex TTT {} ]
type: MolecularInteraction
xref: 20810650
participant: ATM
participant: TTT.complex

TRAF6
type: Protein
entity reference: TRAF6

.PLK1.PROMOTES.CDC25C.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.PLK1.CDC25C
controller: PLK1
xref: 11897663
data source: Spike

POLB
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5423

MLH1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4292

.Complex.CycA.Cdk2....INHIBITS.Complex.APC/C.FZR1...(CDC23).
type: Catalysis
control type: INHIBITION
controlled: Phosphorylation.I.CycA.Cdk2.APC/C.FZR1
controller: CycA-Cdk2.complex
xref: 11340163
data source: Spike

http://www.ncbi.nlm.nih.gov/#142
type: UnificationXref
db: Entrez Gene
id: 142

GMNN
type: Protein
entity reference: GMNN

MLH1_DNA
type: DnaRegion
entity reference: MLH1

LATS1
type: Protein
entity reference: LATS1

PPP2CA
type: Protein
entity reference: PPP2CA

11687627
type: PublicationXref
db: PubMed
id: 11687627
title: Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage

EXO1_inactive
type: Protein
entity reference: EXO1

12773400
type: PublicationXref
db: PubMed
id: 12773400
title: A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein

12919958
type: PublicationXref
db: PubMed
id: 12919958
title: ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses

Translation
type: MolecularInteraction
participant: CDKN1A
participant: CDKN1A_RNA

BLM_inactive
type: Protein
entity reference: BLM

20639885
type: PublicationXref
db: PubMed
id: 20639885
title: The C terminus of p53 binds the N-terminal domain of MDM2

HMGA1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3159

MCPH1
type: Protein
entity reference: MCPH1

BAK1
type: Protein
entity reference: BAK1

20713054
type: PublicationXref
db: PubMed
id: 20713054
title: ARF-dependent regulation of ATM and p53 associated KZNF (Apak) protein activity in response to oncogenic stress

Translation
type: MolecularInteraction
participant: RRM2B_inactive
participant: RRM2B_RNA

RBBP8
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5932

Translation
type: MolecularInteraction
participant: APAF1_inactive
participant: APAF1_RNA

BID_inactive
type: Protein
entity reference: BID

http://www.ncbi.nlm.nih.gov/#64326
type: UnificationXref
db: Entrez Gene
id: 64326

18442975
type: PublicationXref
db: PubMed
id: 18442975
title: Regulation of intra-S phase checkpoint by ionizing radiation (IR)-dependent and IR-independent phosphorylation of SMC3

RRM2B_RNA
type: RnaRegion
entity reference: RRM2B

20471956
type: PublicationXref
db: PubMed
id: 20471956
title: Phosphorylation of p300 by ATM controls the stability of NBS1

.ATM.UNKNOWN.RAD9A.
type: Catalysis
control type: ACTIVATION_UNKMECH
controlled: Phosphorylation.U.ATM.RAD9A
controller: ATM
xref: 11278446
data source: Spike

.TRIM28.UNKNOWN.Family.HP1..CBX1..
type: Catalysis
control type: ACTIVATION_UNKMECH
controlled: Physical.Interaction.U.TRIM28.HP1
controller: TRIM28
xref: 12154074
data source: Spike

CHD3_inactive
type: Protein
entity reference: CHD3

IKBKG_inactive
type: Protein
entity reference: IKBKG

ATM_inactive
type: Protein
entity reference: ATM

SIAH1_inactive
type: Protein
entity reference: SIAH1

GADD45A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1647

19851285
type: PublicationXref
db: PubMed
id: 19851285
title: Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK

CDKN1A
type: Protein
entity reference: CDKN1A

CASP3
type: Protein
entity reference: CASP3

RRM2B
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#50484

.ATM.INHIBITS.TRIM28.
type: Catalysis
control type: INHIBITION
controlled: Phosphorylation.I.ATM.TRIM28
controller: ATM
xref: 20424263
xref: 17942393
data source: Spike

SETDB1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9869

12612651
type: PublicationXref
db: PubMed
id: 12612651
title: ATM and related protein kinases: safeguarding genome integrity

PLK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5347

IkB.family
type: Protein
xref: TAU:F.000012
data source: Spike

BLM
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#641

.TRIM28.INHIBITS.BAX.
type: TemplateReactionRegulation
control type: INHIBITION
controlled: Transcription.Regulation.I.TRIM28.BAX
controller: TRIM28
xref: 17942393
data source: Spike

STRAP_inactive
type: Protein
entity reference: STRAP

CHEK1_inactive
type: Protein
entity reference: CHEK1

MIR421
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#693122

10550055
type: PublicationXref
db: PubMed
id: 10550055
title: Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

IRS1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3667

MDC1
type: Protein
entity reference: MDC1

MDC1_inactive
type: Protein
entity reference: MDC1

RRM2B_DNA
type: DnaRegion
entity reference: RRM2B

WEB:0002043
type: UnificationXref
db: Spike DB
id: WEB:0002043

9606
type: UnificationXref
db: taxonomy
id: 9606

TRIM28
type: Protein
entity reference: TRIM28

RAD50
type: Protein
entity reference: RAD50

POLB_inactive
type: Protein
entity reference: POLB

http://www.ncbi.nlm.nih.gov/#3159
type: UnificationXref
db: Entrez Gene
id: 3159

GADD45A
type: Protein
entity reference: GADD45A

http://www.ncbi.nlm.nih.gov/#7013
type: UnificationXref
db: Entrez Gene
id: 7013

http://www.ncbi.nlm.nih.gov/#7014
type: UnificationXref
db: Entrez Gene
id: 7014

VCP
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7415

http://www.ncbi.nlm.nih.gov/#55215
type: UnificationXref
db: Entrez Gene
id: 55215

RAD17
type: Protein
entity reference: RAD17

15492238
type: PublicationXref
db: PubMed
id: 15492238
title: COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas

TRF2.complex
type: Complex
component: TERF2
name: TRF2-RAP1 complex
data source: Spike

.EEF1E1.PROMOTES.ATM.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.EEF1E1.ATM
controller: EEF1E1
xref: 18066086
data source: Spike

http://www.ncbi.nlm.nih.gov/#3364
type: UnificationXref
db: Entrez Gene
id: 3364

TDP1
type: Protein
entity reference: TDP1

http://www.ncbi.nlm.nih.gov/#1020
type: UnificationXref
db: Entrez Gene
id: 1020

CDC25C
type: Protein
entity reference: CDC25C

http://www.ncbi.nlm.nih.gov/#10111
type: UnificationXref
db: Entrez Gene
id: 10111

TTI1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9675

http://www.ncbi.nlm.nih.gov/#1026
type: UnificationXref
db: Entrez Gene
id: 1026

Translation
type: MolecularInteraction
participant: MLH1_RNA
participant: MLH1

9843217
type: PublicationXref
db: PubMed
id: 9843217
title: ATM associates with and phosphorylates p53: mapping the region of interaction

RPA2
type: Protein
entity reference: RPA2

.ATM.PROMOTES.STRAP.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.STRAP
controller: ATM
xref: 18833288
data source: Spike

CDK5
type: Protein
entity reference: CDK5

VCP_inactive
type: Protein
entity reference: VCP

12565178
type: PublicationXref
db: PubMed
id: 12565178
title: Expression of p53R2, newly p53 target in oral normal epithelium, epithelial dysplasia and squamous cell carcinoma.

10807576
type: PublicationXref
db: PubMed
id: 10807576
title: Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

http://www.ncbi.nlm.nih.gov/#57099
type: UnificationXref
db: Entrez Gene
id: 57099

CycA-Cdk2.complex
type: Complex
name: CycA-Cdk2
data source: Spike

CASP3_inactive
type: Protein
entity reference: CASP3

HERC2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8924

http://www.ncbi.nlm.nih.gov/#25
type: UnificationXref
db: Entrez Gene
id: 25

11077446
type: PublicationXref
db: PubMed
id: 11077446
title: PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition

NFkB.complex_inactive
type: Protein

Translation
type: MolecularInteraction
participant: MSH2
participant: MSH2_RNA

STK3
type: Protein
entity reference: STK3

15383534
type: PublicationXref
db: PubMed
id: 15383534
title: Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins

Translation
type: MolecularInteraction
participant: PMAIP1_RNA
participant: PMAIP1

EIF4EBP1
type: Protein
entity reference: EIF4EBP1

21460856
type: PublicationXref
db: PubMed
id: 21460856
title: ATM-mediated phosphorylation activates the tumor-suppressive function of B56-PP2A

.ATM.INHIBITS.CREB1.
type: Catalysis
control type: INHIBITION
controlled: Phosphorylation.I.ATM.CREB1
controller: ATM
xref: 17525332
xref: 15073328
data source: Spike

ORC.complex
type: Complex
name: Origion Recognition Complex
data source: Spike

GMNN
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#51053

14726021
type: PublicationXref
db: PubMed
id: 14726021
title: Repair of DNA double strand breaks by non-homologous end joining

RAD50
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#10111

.ATM.INHIBITS.ATF1.
type: Catalysis
control type: INHIBITION
controlled: Phosphorylation.I.ATM.ATF1
controller: ATM
xref: 20730097
data source: Spike

mir181.family
type: Protein
xref: WEB:0002043
data source: Spike

E2F1
type: Protein
entity reference: E2F1

11278964
type: PublicationXref
db: PubMed
id: 11278964
title: Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies

18319725
type: PublicationXref
db: PubMed
id: 18319725
title: A comprehensive modular map of molecular interactions in RB/E2F pathway

BBC3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#27113

18077418
type: PublicationXref
db: PubMed
id: 18077418
title: Profiling of UV-induced ATM/ATR signaling pathways

20810650
type: PublicationXref
db: PubMed
id: 20810650
title: A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability

16223874
type: PublicationXref
db: PubMed
id: 16223874
title: DNA damage-induced phosphorylation of the human telomere-associated protein TRF2

SMC1A
type: Protein
entity reference: SMC1A

http://www.ncbi.nlm.nih.gov/#11171
type: UnificationXref
db: Entrez Gene
id: 11171

.RASSF1.PROMOTES.STK3.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.RASSF1.STK3
controller: RASSF1
xref: 17889669
xref: 19962312
xref: 21199877
data source: Spike

Sheltrin.complex
type: Complex
component: TERF1
component: TINF2
component: TERF2
name: Sheltrin (Telomers protection complex)
data source: Spike

RIPK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8737

.Family.mir181....INHIBITS.ATM.
type: Catalysis
control type: INHIBITION
controlled: Translational.Regulation.I.mir181.ATM
controller: mir181.family
xref: 21102523
data source: Spike

.ATM.UNKNOWN.TERF1.
type: Catalysis
control type: ACTIVATION_UNKMECH
controlled: Phosphorylation.U.ATM.TERF1
controller: ATM
xref: 11375976
data source: Spike

RASSF1
type: Protein
entity reference: RASSF1

.ATM.PROMOTES.SRSF1.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.SRSF1
controller: ATM
xref: 18070599
data source: Spike

.GMNN.INHIBITS.Complex.pre RC..CDC6,.MCM2,.MCM3.(CDC6).
type: Catalysis
control type: INHIBITION
controlled: Physical.Interaction.I.GMNN.pre RC
controller: GMNN
xref: 15380092
data source: Spike

.HIPK2.PROMOTES.TP53.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.HIPK2.TP53
controller: HIPK2
xref: 17332358
data source: Spike

.APAF1.PROMOTES.CASP9.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.APAF1.CASP9
controller: APAF1
xref: 9922454
xref: 9488720
data source: Spike

.H2AFX.PROMOTES.MCPH1.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.H2AFX.MCPH1
controller: H2AFX
xref: 17599047
data source: Spike

http://www.ncbi.nlm.nih.gov/#11186
type: UnificationXref
db: Entrez Gene
id: 11186

.ATM.PROMOTES.TRAF6.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.ATM.TRAF6
controller: ATM
xref: 21872579
xref: 20932475
data source: Spike

11959841
type: PublicationXref
db: PubMed
id: 11959841
title: setdb1: a novel kap-1 associated hustone h3, lysin 9 specific methyltransferasethat contributes to hp1 mediated silencing of euchromatic genes by krab zinc finger proteins

EIF4EBP1_inactive
type: Protein
entity reference: EIF4EBP1

PRKDC
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5591

16990795
type: PublicationXref
db: PubMed
id: 16990795
title: Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit

16857680
type: PublicationXref
db: PubMed
id: 16857680
title: Interplay between Ku, artemis and DNA-PKcs at DNA ends

TP73
type: Protein
entity reference: TP73

PPP2R5D
type: Protein
entity reference: PPP2R5D

15173573
type: PublicationXref
db: PubMed
id: 15173573
title: ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP

CHEK2
type: Protein
entity reference: CHEK2

.Complex.CycA.Cdk2....INHIBITS.CDC6.
type: Catalysis
control type: INHIBITION
controlled: Phosphorylation.I.CycA.Cdk2.CDC6
controller: CycA-Cdk2.complex
xref: 9889196
data source: Spike

LATS1_inactive
type: Protein
entity reference: LATS1

TTI1
type: Protein
entity reference: TTI1

MCM2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4171

.RIPK1.PROMOTES.Complex.IKK..IKBKG..
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.RIPK1.IKK
controller: RIPK1
xref: 12654725
data source: Spike

PP2A.complex
type: Complex
name: Protein phosphatase 2A
data source: Spike

MLH1_RNA
type: RnaRegion
entity reference: MLH1

BID_RNA
type: RnaRegion
entity reference: BID

18171990
type: PublicationXref
db: PubMed
id: 18171990
title: Phosphorylation of Sp1 in response to DNA damage by ataxia telangiectasia-mutated kinase

21872579
type: PublicationXref
db: PubMed
id: 21872579
title: Importance of PIKKs in NF-B activation by genotoxic stress

.BID.PROMOTES.BAX.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.BID.BAX
controller: BID
xref: 15574335
data source: Spike

CASP3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#836

19412162
type: PublicationXref
db: PubMed
id: 19412162
title: F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage

APAF1
type: Protein
entity reference: APAF1

20080624
type: PublicationXref
db: PubMed
id: 20080624
title: ATM is down-regulated by N-Myc-regulated microRNA-421

TP53BP1
type: Protein
entity reference: TP53BP1

BAK1_inactive
type: Protein
entity reference: BAK1

http://www.ncbi.nlm.nih.gov/#26277
type: UnificationXref
db: Entrez Gene
id: 26277

16901786
type: PublicationXref
db: PubMed
id: 16901786
title: A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response

http://www.ncbi.nlm.nih.gov/#5111
type: UnificationXref
db: Entrez Gene
id: 5111

9858545
type: PublicationXref
db: PubMed
id: 9858545
title: p21(Waf1/Cip1) inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption

CEP164_inactive
type: Protein
entity reference: CEP164

EP300
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2033

PARP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#142

http://www.ncbi.nlm.nih.gov/#1386
type: UnificationXref
db: Entrez Gene
id: 1386

HP1.family_inactive
type: Protein

TP73
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7161

http://www.ncbi.nlm.nih.gov/#1385
type: UnificationXref
db: Entrez Gene
id: 1385

FANCI
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#55215

20932475
type: PublicationXref
db: PubMed
id: 20932475
title: A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-B activation

http://www.ncbi.nlm.nih.gov/#1978
type: UnificationXref
db: Entrez Gene
id: 1978

16009723
type: PublicationXref
db: PubMed
id: 16009723
title: Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

.TRIM28.INHIBITS.PMAIP1.
type: TemplateReactionRegulation
control type: INHIBITION
controlled: Transcription.Regulation.I.TRIM28.PMAIP1
controller: TRIM28
xref: 17942393
data source: Spike

19579266
type: PublicationXref
db: PubMed
id: 19579266
title: Efficient activation of p53 pathway in A549 cells exposed to L2, a novel compound targeting p53-MDM2 interaction

11423996
type: PublicationXref
db: PubMed
id: 11423996
title: DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1

AKT1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#207

17412408
type: PublicationXref
db: PubMed
id: 17412408
title: Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair

21102523
type: PublicationXref
db: PubMed
id: 21102523
title: Transforming growth factor- regulates the sphere-initiating stem cell-like feature in breast cancer through miRNA-181 and ATM

MCPH1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#79648

.ATM.PROMOTES.EIF4EBP1.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.EIF4EBP1
controller: ATM
xref: 11146653
data source: Spike

PPP2R5C
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5527

E2F1_inactive
type: Protein
entity reference: E2F1

18848520
type: PublicationXref
db: PubMed
id: 18848520
title: SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint

Telomerase.complex
type: Complex
name: Telomerase holoenzyme
data source: Spike

C1QBP_inactive
type: Protein
entity reference: C1QBP

.ATM.PROMOTES.TP53BP1.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.TP53BP1
controller: ATM
xref: 18644834
xref: 18996087
data source: Spike

CHEK2_inactive
type: Protein
entity reference: CHEK2

http://www.ncbi.nlm.nih.gov/#79791
type: UnificationXref
db: Entrez Gene
id: 79791

http://www.ncbi.nlm.nih.gov/#51053
type: UnificationXref
db: Entrez Gene
id: 51053

18082599
type: PublicationXref
db: PubMed
id: 18082599
title: The DNA damage response: ten years after

RAD9A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5883

CLSPN_inactive
type: Protein
entity reference: CLSPN

8348613
type: PublicationXref
db: PubMed
id: 8348613
title: Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase

YAP1_inactive
type: Protein
entity reference: YAP1

PhysicalInteraction [TERF2 -- TINF2 ]
type: MolecularInteraction
comment: intact:EBI-764866
xref: 17145710
xref: 15383534
participant: TINF2
participant: TERF2

CHEK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1111

RIF1_inactive
type: Protein
entity reference: RIF1

ATF1_inactive
type: Protein
entity reference: ATF1

GADD45A_RNA
type: RnaRegion
entity reference: GADD45A

.Complex.CK2....PROMOTES.MDC1.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.CK2.MDC1
controller: CK2.complex
xref: 18411307
xref: 18772547
data source: Spike

http://www.ncbi.nlm.nih.gov/#9521
type: UnificationXref
db: Entrez Gene
id: 9521

17525332
type: PublicationXref
db: PubMed
id: 17525332
title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

http://www.ncbi.nlm.nih.gov/#50484
type: UnificationXref
db: Entrez Gene
id: 50484

PMAIP1
type: Protein
entity reference: PMAIP1

TERF2
type: Protein
entity reference: TERF2

TRIM28
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#10155

.CREB1.PROMOTES.ATM.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.CREB1.ATM
controller: CREB1
xref: 20730097
data source: Spike

18438399
type: PublicationXref
db: PubMed
id: 18438399
title: HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response

RPA2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6118

CASP9_inactive
type: Protein
entity reference: CASP9

MDM2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4193

http://www.ncbi.nlm.nih.gov/#7158
type: UnificationXref
db: Entrez Gene
id: 7158

http://www.ncbi.nlm.nih.gov/#7157
type: UnificationXref
db: Entrez Gene
id: 7157

FBXO31_inactive
type: Protein
entity reference: FBXO31

16603769
type: PublicationXref
db: PubMed
id: 16603769
title: The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM

11146653
type: PublicationXref
db: PubMed
id: 11146653
title: Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1

http://www.ncbi.nlm.nih.gov/#7161
type: UnificationXref
db: Entrez Gene
id: 7161

CDC6
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#990

.BLM.PROMOTES.Complex.CAF.1...(CHAF1A).
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.BLM.CAF.1
controller: BLM
xref: 15143166
data source: Spike

AVEN
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#57099

TERF1_inactive
type: Protein
entity reference: TERF1

http://www.ncbi.nlm.nih.gov/#9937
type: UnificationXref
db: Entrez Gene
id: 9937

20424263
type: PublicationXref
db: PubMed
id: 20424263
title: SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1

BAK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#578

.KAT5.PROMOTES.ATM.
type: Catalysis
control type: ACTIVATION
controlled: Acetylation.P.KAT5.ATM
controller: KAT5
xref: 16141325
data source: Spike

18762365
type: PublicationXref
db: PubMed
id: 18762365
title: Insulin-like growth factor-1 attenuates cisplatin-induced gammaH2AX formation and DNA double-strand breaks repair pathway in non-small cell lung cancer

http://www.ncbi.nlm.nih.gov/#57646
type: UnificationXref
db: Entrez Gene
id: 57646

APC/C-FZR1.complex
type: Complex
name: Anaphase promoting complex / FZR1(CDH1) activator
data source: Spike

http://www.ncbi.nlm.nih.gov/#10155
type: UnificationXref
db: Entrez Gene
id: 10155

ATM
type: Protein
entity reference: ATM

11463392
type: PublicationXref
db: PubMed
id: 11463392
title: PUMA, a novel proapoptotic gene, is induced by p53

.Complex.DNA.PK..PRKDC..PROMOTES.DCLRE1C.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.DNA.PK.DCLRE1C
controller: DNA-PK.complex
xref: 14726021
data source: Spike

19151707
type: PublicationXref
db: PubMed
id: 19151707
title: Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death

http://www.ncbi.nlm.nih.gov/#6426
type: UnificationXref
db: Entrez Gene
id: 6426

SRSF1_inactive
type: Protein
entity reference: SRSF1

KAT5
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#10524

17189255
type: PublicationXref
db: PubMed
id: 17189255
title: Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break

.BRCA1.INHIBITS.ABL1.
type: Catalysis
control type: INHIBITION
controlled: Physical.Interaction.I.BRCA1.ABL1
controller: BRCA1
xref: 12919958
data source: Spike

DCLRE1C
type: Protein
entity reference: DCLRE1C

.ATM.PROMOTES.RASSF1.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.RASSF1
controller: ATM
xref: 19962312
data source: Spike

Mi-2/NuRD.complex
type: Complex
component: CHD3
name: Mi2-NuRD
data source: Spike

TINF2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#26277

15279790
type: PublicationXref
db: PubMed
id: 15279790
title: Claspin, a regulator of Chk1 in DNA replication stress pathway

RIF1
type: Protein
entity reference: RIF1

.ATM.PROMOTES.EP300.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.EP300
controller: ATM
xref: 20471956
data source: Spike

.ATM.PROMOTES.NBN.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.NBN
controller: ATM
xref: 12861053
xref: 12814430
data source: Spike

.ATM.PROMOTES.FANCI.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.FANCI
controller: ATM
xref: 17412408
xref: 17525332
data source: Spike

Translation
type: MolecularInteraction
participant: GADD45A
participant: GADD45A_RNA

UPF1
type: Protein
entity reference: UPF1

.Complex.Sheltrin..TINF2,.TERF1,.TERF2..INHIBITS.Complex.Telomerase...(DKC1).
type: Catalysis
control type: INHIBITION
controlled: Other.I.Sheltrin.Telomerase
controller: Sheltrin.complex
xref: 19286666
xref: 15189140
data source: Spike

CLSPN
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#63967

http://www.ncbi.nlm.nih.gov/#7189
type: UnificationXref
db: Entrez Gene
id: 7189

SRSF1
type: Protein
entity reference: SRSF1

11230151
type: PublicationXref
db: PubMed
id: 11230151
title: Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD.

ABL1_inactive
type: Protein
entity reference: ABL1

18411307
type: PublicationXref
db: PubMed
id: 18411307
title: Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin

VCP
type: Protein
entity reference: VCP

Homo sapiens
type: BioSource
xref: 9606

12527906
type: PublicationXref
db: PubMed
id: 12527906
title: Identification of target genes for EWS/ATF-1 chimeric transcription factor

18158288
type: PublicationXref
db: PubMed
id: 18158288
title: Tumor suppressor LATS1 is a negative regulator of oncogene YAP

ATM_DNA
type: DnaRegion
entity reference: ATM

15788536
type: PublicationXref
db: PubMed
id: 15788536
title: Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage

.TP53.PROMOTES.PMAIP1.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.TP53.PMAIP1
controller: TP53
xref: 10807576
data source: Spike

http://www.ncbi.nlm.nih.gov/#64421
type: UnificationXref
db: Entrez Gene
id: 64421

.ATM.INHIBITS.UPF1.
type: Catalysis
control type: INHIBITION
controlled: Phosphorylation.I.ATM.UPF1
controller: ATM
xref: 18158334
data source: Spike

http://www.ncbi.nlm.nih.gov/#4436
type: UnificationXref
db: Entrez Gene
id: 4436

10950869
type: PublicationXref
db: PubMed
id: 10950869
title: tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

Telomerase.complex_inactive
type: Protein

TAU:F.000012
type: UnificationXref
db: Spike DB
id: TAU:F-000012

.ATM.PROMOTES.AKT1.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.AKT1
controller: ATM
xref: 15546863
data source: Spike

.KAT5.PROMOTES.PRKDC.
type: Catalysis
control type: ACTIVATION
controlled: Acetylation.P.KAT5.PRKDC
controller: KAT5
xref: 16603769
data source: Spike

DCLRE1A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9937

TAU:F.000016
type: UnificationXref
db: Spike DB
id: TAU:F-000016

EIF4EBP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1978

.ATM.PROMOTES.OBFC2B.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.OBFC2B
controller: ATM
xref: 18449195
data source: Spike

HP1.family
type: Protein
member physical entity: CBX1
xref: TAU:F.000007
data source: Spike

15688006
type: PublicationXref
db: PubMed
id: 15688006
title: The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1

.BID.PROMOTES.BAK1.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.BID.BAK1
controller: BID
xref: 10950869
data source: Spike

CEP164
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#22897

http://www.ncbi.nlm.nih.gov/#5591
type: UnificationXref
db: Entrez Gene
id: 5591

IKK.complex
type: Complex
component: IKBKG
name: IKK complex
data source: Spike

CDC6
type: Protein
entity reference: CDC6

PhysicalInteraction [CBX1 -- HIST3H3 ]
type: MolecularInteraction
xref: 18438399
participant: HIST3H3
participant: CBX1

17145710
type: PublicationXref
db: PubMed
id: 17145710
title: IntAct--open source resource for molecular interaction data

18449195
type: PublicationXref
db: PubMed
id: 18449195
title: Single-stranded DNA-binding protein hSSB1 is critical for genomic stability

9733515
type: PublicationXref
db: PubMed
id: 9733515
title: Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

9733514
type: PublicationXref
db: PubMed
id: 9733514
title: Enhanced phosphorylation of p53 by ATM in response to DNA damage

MRE11A
type: Protein
entity reference: MRE11A

CycE-Cdk2.complex_inactive
type: Protein

SP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6667

ABL1
type: Protein
entity reference: ABL1

.MDM2.INHIBITS.TP53.
type: Catalysis
control type: INHIBITION
controlled: Physical.Interaction.I.MDM2.TP53
controller: MDM2
xref: 11331603
xref: 20639885
xref: 19579266
data source: Spike

.ATM.PROMOTES.BID.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.BID
controller: ATM
xref: 18662573
xref: 16122426
xref: 16122425
data source: Spike

18451105
type: PublicationXref
db: PubMed
id: 18451105
title: Chk1 and Claspin potentiate PCNA ubiquitination

CASP9
type: Protein
entity reference: CASP9

RAD9A_inactive
type: Protein
entity reference: RAD9A

.ATM.UNKNOWN.RPA2.
type: Catalysis
control type: ACTIVATION_UNKMECH
controlled: Phosphorylation.U.ATM.RPA2
controller: ATM
xref: 14872059
data source: Spike

HIST3H3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8290

18025084
type: PublicationXref
db: PubMed
id: 18025084
title: PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites

15210935
type: PublicationXref
db: PubMed
id: 15210935
title: Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases

.ATM.UNKNOWN.C1QBP.
type: Catalysis
control type: ACTIVATION_UNKMECH
controlled: Phosphorylation.U.ATM.C1QBP
controller: ATM
xref: 18070599
data source: Spike

ATF1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#466

CHEK2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#11200

.ATM.PROMOTES.ATF2.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.ATF2
controller: ATM
xref: 15916964
data source: Spike

.Complex.911.complex..HUS1..PROMOTES.POLB.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.911.complex.POLB
controller: 911-complex.complex
xref: 15314187
data source: Spike

RRM2B
type: Protein
entity reference: RRM2B

18662573
type: PublicationXref
db: PubMed
id: 18662573
title: Investigation of the proapoptotic BCL-2 family member bid on the crossroad of the DNA damage response and apoptosis

18431400
type: PublicationXref
db: PubMed
id: 18431400
title: Transcriptional control of human p53-regulated genes

http://www.ncbi.nlm.nih.gov/#5976
type: UnificationXref
db: Entrez Gene
id: 5976

BID_DNA
type: DnaRegion
entity reference: BID

CDKN1A_RNA
type: RnaRegion
entity reference: CDKN1A

MRN.complex
type: Complex
component: NBN
component: MRE11A
component: RAD50
name: MRE11-RAD50-NBS1
data source: Spike

http://www.ncbi.nlm.nih.gov/#6667
type: UnificationXref
db: Entrez Gene
id: 6667

.TP53.PROMOTES.BBC3.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.TP53.BBC3
controller: TP53
xref: 11463392
xref: 12574499
data source: Spike

19749794
type: PublicationXref
db: PubMed
id: 19749794
title: Pro-proliferative FoxM1 is a target of p53-mediated repression

http://www.ncbi.nlm.nih.gov/#6477
type: UnificationXref
db: Entrez Gene
id: 6477

.ATM.PROMOTES.FBXO31.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.FBXO31
controller: ATM
xref: 19412162
data source: Spike

http://www.ncbi.nlm.nih.gov/#147923
type: UnificationXref
db: Entrez Gene
id: 147923

15840767
type: PublicationXref
db: PubMed
id: 15840767
title: Ataxia telangiectasia-mutated, a DNA damage-inducible kinase, contributes to high NaCl-induced nuclear localization of transcription factor TonEBP/OREBP

11559530
type: PublicationXref
db: PubMed
id: 11559530
title: APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis

11418864
type: PublicationXref
db: PubMed
id: 11418864
title: ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses

http://www.ncbi.nlm.nih.gov/#2177
type: UnificationXref
db: Entrez Gene
id: 2177

TP53BP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7158

Lig_IV - XRCC4.complex
type: Complex
name: Ligase_4 - XRCC4
data source: Spike

CycB-Cdc2.complex
type: Complex
name: CyclinB-Cdc2 (CDK1)- M-phase-promoting factor (MPF)
data source: Spike

ATM_RNA
type: RnaRegion
entity reference: ATM

CK2.complex
type: Complex
name: Caseine Kinase 2
data source: Spike

CEP164
type: Protein
entity reference: CEP164

.ATM.PROMOTES.DCLRE1A.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.DCLRE1A
controller: ATM
xref: 18848520
xref: 15456891
data source: Spike

http://www.ncbi.nlm.nih.gov/#5366
type: UnificationXref
db: Entrez Gene
id: 5366

12578958
type: PublicationXref
db: PubMed
id: 12578958
title: Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro

http://www.ncbi.nlm.nih.gov/#990
type: UnificationXref
db: Entrez Gene
id: 990

Spike
type: Provenance

AKT1_inactive
type: Protein
entity reference: AKT1

FANCI_inactive
type: Protein
entity reference: FANCI

RAD17
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5884

http://www.ncbi.nlm.nih.gov/#708
type: UnificationXref
db: Entrez Gene
id: 708

11278446
type: PublicationXref
db: PubMed
id: 11278446
title: ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation

http://www.ncbi.nlm.nih.gov/#995
type: UnificationXref
db: Entrez Gene
id: 995

DCLRE1C_inactive
type: Protein
entity reference: DCLRE1C

.BAX.PROMOTES.APAF1.
type: Catalysis
control type: ACTIVATION
controlled: Other.P.BAX.APAF1
controller: BAX
xref: 11709054
data source: Spike

H2AFX
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3014

MDM4
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4194

http://www.ncbi.nlm.nih.gov/#317
type: UnificationXref
db: Entrez Gene
id: 317

.CHEK2.INHIBITS.CDC25C.
type: Catalysis
control type: INHIBITION
controlled: Phosphorylation.I.CHEK2.CDC25C
controller: CHEK2
xref: 10681541
data source: Spike

STK3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6788

11313881
type: PublicationXref
db: PubMed
id: 11313881
title: Expression analysis using DNA microarrays demonstrates that E2F-1 up-regulates expression of DNA replication genes including replication protein A2

.IRS1.PROMOTES.ATM.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.IRS1.ATM
controller: IRS1
xref: 18762365
data source: Spike

AVEN
type: Protein
entity reference: AVEN

911-complex.complex_inactive
type: Protein

IKK.complex_inactive
type: Protein

http://www.ncbi.nlm.nih.gov/#5347
type: UnificationXref
db: Entrez Gene
id: 5347

15143166
type: PublicationXref
db: PubMed
id: 15143166
title: Physical and functional interaction between the Bloom's syndrome gene product and the largest subunit of chromatin assembly factor 1

.ATM.PROMOTES.DCLRE1C.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.DCLRE1C
controller: ATM
xref: 15468306
xref: 15456891
data source: Spike

TERF1
type: Protein
entity reference: TERF1

http://www.ncbi.nlm.nih.gov/#578
type: UnificationXref
db: Entrez Gene
id: 578

http://www.ncbi.nlm.nih.gov/#4292
type: UnificationXref
db: Entrez Gene
id: 4292

http://www.ncbi.nlm.nih.gov/#10413
type: UnificationXref
db: Entrez Gene
id: 10413

15916964
type: PublicationXref
db: PubMed
id: 15916964
title: ATM-dependent phosphorylation of ATF2 is required for the DNA damage response

15838523
type: PublicationXref
db: PubMed
id: 15838523
title: The p53 pathway: positive and negative feedback loops

DNA-PK.complex
type: Complex
component: PRKDC
name: DNA-PK
data source: Spike

.TP53.PROMOTES.GADD45A.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.TP53.GADD45A
controller: TP53
xref: 16990795
xref: 14627995
xref: 15603758
data source: Spike

AKT1
type: Protein
entity reference: AKT1

.Family.IkB....INHIBITS.Complex.NFkB....
type: Catalysis
control type: INHIBITION
controlled: Physical.Interaction.I.IkB.NFkB
controller: IkB.family
xref: 10644043
data source: Spike

http://www.ncbi.nlm.nih.gov/#581
type: UnificationXref
db: Entrez Gene
id: 581

.MIR421.INHIBITS.ATM.
type: Catalysis
control type: INHIBITION
controlled: mRNA.stability.I.MIR421.ATM
controller: MIR421
xref: 21741842
xref: 20080624
data source: Spike

http://www.ncbi.nlm.nih.gov/#5932
type: UnificationXref
db: Entrez Gene
id: 5932

.ATM.INHIBITS.SIAH1.
type: Catalysis
control type: INHIBITION
controlled: Phosphorylation.I.ATM.SIAH1
controller: ATM
xref: 19788416
data source: Spike

21741842
type: PublicationXref
db: PubMed
id: 21741842
title: miRNA response to DNA damage

ATF1
type: Protein
entity reference: ATF1

TERF1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7013

MDM2_DNA
type: DnaRegion
entity reference: MDM2

MSH2
type: Protein
entity reference: MSH2

15678131
type: PublicationXref
db: PubMed
id: 15678131
title: The anaphase-promoting complex: a key factor in the regulation of cell cycle

APAF1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#317

9889122
type: PublicationXref
db: PubMed
id: 9889122
title: A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

NuA4.complex
type: Complex
name: NuA4/Tip60 HAT complex
data source: Spike

.ATM.UNKNOWN.VCP.
type: Catalysis
control type: ACTIVATION_UNKMECH
controlled: Phosphorylation.U.ATM.VCP
controller: ATM
xref: 16140914
data source: Spike

10644043
type: PublicationXref
db: PubMed
id: 10644043
title: Suppression of lipopolysaccharide-induced nuclear factor-kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages

CDC6_inactive
type: Protein
entity reference: CDC6

MDC1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9656

PCNA_inactive
type: Protein
entity reference: PCNA

.ATM.PROMOTES.PPP2R5C.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.PPP2R5C
controller: ATM
xref: 21460856
data source: Spike

BRCA1
type: Protein
entity reference: BRCA1

CDC25C_inactive
type: Protein
entity reference: CDC25C

USP28
type: Protein
entity reference: USP28

KAT5
type: Protein
entity reference: KAT5

12383116
type: PublicationXref
db: PubMed
id: 12383116
title: Highly potent p21(WAF1)-derived peptide inhibitors of CDK-mediated pRb phosphorylation: delineation and structural insight into their interactions with cyclin A

21655083
type: PublicationXref
db: PubMed
id: 21655083
title: Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis

16497931
type: PublicationXref
db: PubMed
id: 16497931
title: Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli

18285803
type: PublicationXref
db: PubMed
id: 18285803
title: Regulation of DNA repair throughout the cell cycle

BID
type: Protein
entity reference: BID

STK3_inactive
type: Protein
entity reference: STK3

STK11
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6794

DNA-PK.complex_inactive
type: Protein

.ATM.PROMOTES.HERC2.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.HERC2
controller: ATM
xref: 20023648
data source: Spike

PhysicalInteraction [ATM -- TTI1 ]
type: MolecularInteraction
xref: 20427287
xref: 20810650
participant: ATM
participant: TTI1

.ATM.PROMOTES.PPP2R5D.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.PPP2R5D
controller: ATM
xref: 21460856
data source: Spike

RPA2_RNA
type: RnaRegion
entity reference: RPA2

TP53
type: Protein
entity reference: TP53

15603758
type: PublicationXref
db: PubMed
id: 15603758
title: Gadd45a, a p53- and BRCA1-regulated stress protein, in cellular response to DNA damage

http://www.ncbi.nlm.nih.gov/#8243
type: UnificationXref
db: Entrez Gene
id: 8243

.PLK1.INHIBITS.CLSPN.
type: Catalysis
control type: INHIBITION
controlled: Phosphorylation.I.PLK1.CLSPN
controller: PLK1
xref: 15163406
data source: Spike

HUS1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3364

.PARP1.PROMOTES.ATM.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.PARP1.ATM
controller: PARP1
xref: 17459151
xref: 18025084
data source: Spike

NFkB.complex
type: Complex
name: Nuclear factor kappa-B
data source: Spike

http://www.ncbi.nlm.nih.gov/#4361
type: UnificationXref
db: Entrez Gene
id: 4361

POLB
type: Protein
entity reference: POLB

.ATM.PROMOTES.AVEN.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.AVEN
controller: ATM
xref: 18571408
data source: Spike

CycB-Cdc2.complex_inactive
type: Protein

11331603
type: PublicationXref
db: PubMed
id: 11331603
title: ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

.MDC1.PROMOTES.TP53BP1.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.MDC1.TP53BP1
controller: MDC1
xref: 16009723
data source: Spike

.MDC1.PROMOTES.ATM.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.MDC1.ATM
controller: MDC1
xref: 16427009
data source: Spike

17332358
type: PublicationXref
db: PubMed
id: 17332358
title: Homeodomain-Interacting Protein Kinase 2 Is the Ionizing Radiation-Activated p53 Serine 46 Kinase and Is Regulated by ATM

.LATS1.PROMOTES.YAP1.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.LATS1.YAP1
controller: LATS1
xref: 18158288
data source: Spike

.DCLRE1C.PROMOTES.Complex.Lig IV...XRCC4...(XRCC4).
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.DCLRE1C.Lig IV...XRCC4
controller: DCLRE1C
xref: 16857680
data source: Spike

CHD3
type: Protein
entity reference: CHD3

.HUS1.PROMOTES.PCNA.
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.HUS1.PCNA
controller: HUS1
xref: 11077446
data source: Spike

SIAH1
type: Protein
entity reference: SIAH1

CBX1_inactive
type: Protein
entity reference: CBX1

Cohesin.complex
type: Complex
component: SMC1A
component: SMC3
name: Cohesin (mytotic)
data source: Spike

15073328
type: PublicationXref
db: PubMed
id: 15073328
title: Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress

16141325
type: PublicationXref
db: PubMed
id: 16141325
title: A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

HUS1
type: Protein
entity reference: HUS1

APAF1_DNA
type: DnaRegion
entity reference: APAF1

HIPK2_inactive
type: Protein
entity reference: HIPK2

RBBP8
type: Protein
entity reference: RBBP8

18160036
type: PublicationXref
db: PubMed
id: 18160036
title: Tel2 regulates the stability of PI3K-related protein kinases

http://www.ncbi.nlm.nih.gov/#8290
type: UnificationXref
db: Entrez Gene
id: 8290

10681541
type: PublicationXref
db: PubMed
id: 10681541
title: The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

12748190
type: PublicationXref
db: PubMed
id: 12748190
title: p21/CDKN1A mediates negative regulation of transcription by p53

9390557
type: PublicationXref
db: PubMed
id: 9390557
title: Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

16122426
type: PublicationXref
db: PubMed
id: 16122426
title: Proapoptotic BID is an ATM effector in the DNA-damage response

16122425
type: PublicationXref
db: PubMed
id: 16122425
title: A role for proapoptotic BID in the DNA-damage response

USP28_inactive
type: Protein
entity reference: USP28

.ATM.PROMOTES.HIPK2.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.HIPK2
controller: ATM
xref: 17332358
data source: Spike

.CHEK1.INHIBITS.CDC25C.
type: Catalysis
control type: INHIBITION
controlled: Phosphorylation.I.CHEK1.CDC25C
controller: CHEK1
xref: 10681541
data source: Spike

TTT.complex
type: Complex
name: Triple T (TELO2, TTI1, TTI2)
data source: Spike

7834749
type: PublicationXref
db: PubMed
id: 7834749
title: Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

12402042
type: PublicationXref
db: PubMed
id: 12402042
title: BID regulation by p53 contributes to chemosensitivity

DCLRE1C
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#64421

NFAT5
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#10725

http://www.ncbi.nlm.nih.gov/#28996
type: UnificationXref
db: Entrez Gene
id: 28996

SP1
type: Protein
entity reference: SP1

18783938
type: PublicationXref
db: PubMed
id: 18783938
title: HMGA1 protein is a novel target of the ATM kinase

TP53BP1_inactive
type: Protein
entity reference: TP53BP1

PLK1
type: Protein
entity reference: PLK1

BAX
type: Protein
entity reference: BAX

15574335
type: PublicationXref
db: PubMed
id: 15574335
title: The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA

TAU:F.000007
type: UnificationXref
db: Spike DB
id: TAU:F-000007

11877376
type: PublicationXref
db: PubMed
id: 11877376
title: Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

FANCD2_inactive
type: Protein
entity reference: FANCD2

TRIM28_inactive
type: Protein
entity reference: TRIM28

AVEN_inactive
type: Protein
entity reference: AVEN

15380092
type: PublicationXref
db: PubMed
id: 15380092
title: Regulation of early events in chromosome replication

.RAD17.PROMOTES.Complex.911.complex..HUS1.(RAD9A).
type: Catalysis
control type: ACTIVATION
controlled: Physical.Interaction.P.RAD17.911.complex
controller: RAD17
xref: 18082599
data source: Spike

.ATF1.PROMOTES.ATM.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.ATF1.ATM
controller: ATF1
xref: 12527906
data source: Spike

19286666
type: PublicationXref
db: PubMed
id: 19286666
title: Chromosome end maintenance by telomerase

FANCD2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2177

SETDB1_inactive
type: Protein
entity reference: SETDB1

.TP53.PROMOTES.MDM2.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.TP53.MDM2
controller: TP53
xref: 20624280
xref: 9260156
xref: 15838523
xref: 11328884
data source: Spike

PMAIP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5366

BBC3_DNA
type: DnaRegion
entity reference: BBC3

TELO2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9894

12034743
type: PublicationXref
db: PubMed
id: 12034743
title: Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM

E2F1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1869

MCM.complex
type: Complex
component: MCM2
component: MCM3
name: minichromosome maintenance complex
data source: Spike

.RBBP8.INHIBITS.BRCA1.
type: Catalysis
control type: INHIBITION
controlled: Physical.Interaction.I.RBBP8.BRCA1
controller: RBBP8
xref: 9738006
data source: Spike

http://www.ncbi.nlm.nih.gov/#1111
type: UnificationXref
db: Entrez Gene
id: 1111

.TP53.PROMOTES.APAF1.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.TP53.APAF1
controller: TP53
xref: 11559530
xref: 11389439
xref: 11423996
data source: Spike

11389439
type: PublicationXref
db: PubMed
id: 11389439
title: Apaf-1 is a transcriptional target for E2F and p53

TRAF6
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7189

TELO2
type: Protein
entity reference: TELO2

http://www.ncbi.nlm.nih.gov/#1107
type: UnificationXref
db: Entrez Gene
id: 1107

NBN_inactive
type: Protein
entity reference: NBN

RRM2B_inactive
type: Protein
entity reference: RRM2B

.ATM.PROMOTES.HMGA1.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.HMGA1
controller: ATM
xref: 17525332
xref: 21339738
xref: 18783938
data source: Spike

.ATM.UNKNOWN.MCM3.
type: Catalysis
control type: ACTIVATION_UNKMECH
controlled: Phosphorylation.U.ATM.MCM3
controller: ATM
xref: 15210935
data source: Spike

20023648
type: PublicationXref
db: PubMed
id: 20023648
title: HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

SMC3_inactive
type: Protein
entity reference: SMC3

HMGA2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8091

11375976
type: PublicationXref
db: PubMed
id: 11375976
title: Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks

15456891
type: PublicationXref
db: PubMed
id: 15456891
title: Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response

PRKDC
type: Protein
entity reference: PRKDC

15194694
type: PublicationXref
db: PubMed
id: 15194694
title: Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase

RASSF1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#11186

.ATM.PROMOTES.HMGA2.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.HMGA2
controller: ATM
xref: 21339738
data source: Spike

.ATM.PROMOTES.TERF2.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.TERF2
controller: ATM
xref: 16223874
data source: Spike

MCPH1_inactive
type: Protein
entity reference: MCPH1

BRCA1_inactive
type: Protein
entity reference: BRCA1

RAD17-RFC.complex
type: Complex
component: RAD17
name: RAD17-RFC
data source: Spike

11328884
type: PublicationXref
db: PubMed
id: 11328884
title: Binding to the naturally occurring double p53 binding site of the Mdm2 promoter alleviates the requirement for p53 C-terminal activation

9488720
type: PublicationXref
db: PubMed
id: 9488720
title: Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex

21163364
type: PublicationXref
db: PubMed
id: 21163364
title: Dose-dependent mutual regulation between Wip1 and p53 following UVC irradiation

.CDKN1A.INHIBITS.Complex.CycA.Cdk2....
type: Catalysis
control type: INHIBITION
controlled: Physical.Interaction.I.CDKN1A.CycA.Cdk2
controller: CDKN1A
xref: 12383116
data source: Spike

MCM3_inactive
type: Protein
entity reference: MCM3

OBFC2B
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#79035

TRAF6_inactive
type: Protein
entity reference: TRAF6

.Complex.APC/C.FZR1....INHIBITS.CDC6.
type: Catalysis
control type: INHIBITION
controlled: Ubiquitination.I.APC/C.FZR1.CDC6
controller: APC/C-FZR1.complex
xref: 15678131
data source: Spike

.TRIM28.INHIBITS.GADD45A.
type: TemplateReactionRegulation
control type: INHIBITION
controlled: Transcription.Regulation.I.TRIM28.GADD45A
controller: TRIM28
xref: 17942393
data source: Spike

C1QBP
type: Protein
entity reference: C1QBP

.ATM.PROMOTES.Complex.DNA.PK..PRKDC.(PRKDC).
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.DNA.PK
controller: ATM
xref: 17189255
data source: Spike

RPA.complex
type: Complex
component: RPA2
name: Replication Protein A
data source: Spike

ATF2
type: Protein
entity reference: ATF2

12209975
type: PublicationXref
db: PubMed
id: 12209975
title: p53 status correlates with the differential expression of the DNA mismatch repair protein MSH2 in non-small cell lung carcinoma

HIST3H3
type: Protein
entity reference: HIST3H3

.ATM.INHIBITS.ZNF420.
type: Catalysis
control type: INHIBITION
controlled: Phosphorylation.I.ATM.ZNF420
controller: ATM
xref: 20713054
data source: Spike

EEF1E1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9521

18833288
type: PublicationXref
db: PubMed
id: 18833288
title: ATM and Chk2 kinase target the p53 cofactor Strap

HERC2_inactive
type: Protein
entity reference: HERC2

CREB1_inactive
type: Protein
entity reference: CREB1

http://www.ncbi.nlm.nih.gov/#8091
type: UnificationXref
db: Entrez Gene
id: 8091

APAF1_inactive
type: Protein
entity reference: APAF1

.E2F1.PROMOTES.RPA2.
type: TemplateReactionRegulation
control type: ACTIVATION
controlled: Transcription.Regulation.P.E2F1.RPA2
controller: E2F1
xref: 11313881
data source: Spike

CDK5
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1020

TINF2
type: Protein
entity reference: TINF2

STRAP
type: Protein
entity reference: STRAP

Translation
type: MolecularInteraction
participant: BAX_RNA
participant: BAX_inactive

PCNA
type: Protein
entity reference: PCNA

.ATM.PROMOTES.TDP1.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.TDP1
controller: ATM
xref: 19851285
data source: Spike

BBC3_RNA
type: RnaRegion
entity reference: BBC3

http://www.ncbi.nlm.nih.gov/#3014
type: UnificationXref
db: Entrez Gene
id: 3014

.ATM.PROMOTES.SMC3.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.SMC3
controller: ATM
xref: 18442975
data source: Spike

MSH2_DNA
type: DnaRegion
entity reference: MSH2

H2AFX
type: Protein
entity reference: H2AFX

.CDK5.PROMOTES.ATM.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.CDK5.ATM
controller: CDK5
xref: 19151707
data source: Spike

17459151
type: PublicationXref
db: PubMed
id: 17459151
title: Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition

BAX_inactive
type: Protein
entity reference: BAX

FANCI
type: Protein
entity reference: FANCI

CASP9
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#842

.ATM.PROMOTES.FANCD2.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.FANCD2
controller: ATM
xref: 12612651
data source: Spike

Translation
type: MolecularInteraction
participant: MDM2
participant: MDM2_RNA

.RFWD2.INHIBITS.TP53.
type: Catalysis
control type: INHIBITION
controlled: Ubiquitination.I.RFWD2.TP53
controller: RFWD2
xref: 15492238
data source: Spike

BAX_DNA
type: DnaRegion
entity reference: BAX

PARP1
type: Protein
entity reference: PARP1

TRF1 complex.complex
type: Complex
component: TERF1
component: TINF2
data source: Spike

.CDC25C.PROMOTES.Complex.CycB.Cdc2....
type: Catalysis
control type: ACTIVATION
controlled: Dephosphorylation.P.CDC25C.CycB.Cdc2
controller: CDC25C
xref: 18319725
xref: 8348613
data source: Spike

ABL1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#25

EP300_inactive
type: Protein
entity reference: EP300

http://www.ncbi.nlm.nih.gov/#55775
type: UnificationXref
db: Entrez Gene
id: 55775

BBC3
type: Protein
entity reference: BBC3

18996087
type: PublicationXref
db: PubMed
id: 18996087
title: S1219 residue of 53BP1 is phosphorylated by ATM kinase upon DNA damage and required for proper execution of DNA damage response

MSH2_RNA
type: RnaRegion
entity reference: MSH2

HMGA1
type: Protein
entity reference: HMGA1

RAD9A
type: Protein
entity reference: RAD9A

ZNF420_inactive
type: Protein
entity reference: ZNF420

15371427
type: PublicationXref
db: PubMed
id: 15371427
title: Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1

.ATM.PROMOTES.SP1.
type: Catalysis
control type: ACTIVATION
controlled: Phosphorylation.P.ATM.SP1
controller: ATM
xref: 18619531
xref: 18171990
data source: Spike

18772547
type: PublicationXref
db: PubMed
id: 18772547
title: Dancing on damaged chromatin: functions of ATM and the RAD50/MRE11/NBS1 complex in cellular responses to DNA damage

SLX4_inactive
type: Protein
entity reference: SLX4

HMGA1_inactive
type: Protein
entity reference: HMGA1

16531125
type: PublicationXref
db: PubMed
id: 16531125
title: gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes