Translation
type: MolecularInteraction
participant: PCNA_inactive
participant: PCNA_RNA

http://www.ncbi.nlm.nih.gov/#83990
type: UnificationXref
id: 83990
db: Entrez Gene

9038370
type: PublicationXref
id: 9038370
title: PCNA: structure, functions and interactions
db: PubMed

BRCA2_RNA
type: RnaRegion
entity reference: BRCA2

15951851
type: PublicationXref
id: 15951851
title: The multiple personalities of the regulatory subunit of protein kinase CK2: CK2 dependent and CK2 independent roles reveal a secret identity for CK2beta
db: PubMed

ATRIP
type: Protein
entity reference: ATRIP

.ATM.PROMOTES.ABL1.
type: Catalysis
controlled: Phosphorylation.P.ATM.ABL1
xref: 9168116
xref: 15686624
control type: ACTIVATION
data source: Spike
controller: ATM

NHEJ1
type: Protein
entity reference: NHEJ1

AURKA
type: Protein
entity reference: AURKA

RNF8_inactive
type: Protein
entity reference: RNF8

UBE2N
type: Protein
entity reference: UBE2N

AURKA
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6790

.PML.PROMOTES.TOPBP1.
type: Catalysis
controlled: Physical.Interaction.P.PML.TOPBP1
xref: 12919958
control type: ACTIVATION
data source: Spike
controller: PML

10859164
type: PublicationXref
id: 10859164
title: Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
db: PubMed

10859163
type: PublicationXref
id: 10859163
title: Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice
db: PubMed

http://www.ncbi.nlm.nih.gov/#9156
type: UnificationXref
id: 9156
db: Entrez Gene

EXO1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9156

http://www.ncbi.nlm.nih.gov/#7486
type: UnificationXref
id: 7486
db: Entrez Gene

HERC2
type: Protein
entity reference: HERC2

http://www.ncbi.nlm.nih.gov/#79035
type: UnificationXref
id: 79035
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#9401
type: UnificationXref
id: 9401
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#9400
type: UnificationXref
id: 9400
db: Entrez Gene

SMC3
type: Protein
entity reference: SMC3

.Complex.CycB.Cdc2....INHIBITS.Complex.RFC...(RFC1).
type: Catalysis
controlled: Phosphorylation.I.CycB.Cdc2.RFC
xref: 12947101
control type: INHIBITION
data source: Spike
controller: CycB-Cdc2.complex

16427009
type: PublicationXref
id: 16427009
title: MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals
db: PubMed

http://www.ncbi.nlm.nih.gov/#165918
type: UnificationXref
id: 165918
db: Entrez Gene

17634560
type: PublicationXref
id: 17634560
title: Polymorphic TP53BP1 and TP53 gene interactions associated with risk of squamous cell carcinoma of the head and neck
db: PubMed

WRN
type: Protein
entity reference: WRN

.E2F1.PROMOTES.RAD51.
type: TemplateReactionRegulation
controlled: Transcription.Regulation.P.E2F1.RAD51
xref: 17218262
control type: ACTIVATION
data source: Spike
controller: E2F1

19270065
type: PublicationXref
id: 19270065
title: MRE11 complex links RECQ5 helicase to sites of DNA damage
db: PubMed

11278509
type: PublicationXref
id: 11278509
title: Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51
db: PubMed

WRN
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7486

.Complex.NuA4..KAT5,.ACTL6A..PROMOTES.Family.H4...(HIST2H4B).
type: Catalysis
controlled: Acetylation.P.NuA4.H4
xref: 16904321
xref: 14966270
control type: ACTIVATION
data source: Spike
controller: NuA4.complex

RMI1
type: Protein
entity reference: RMI1

XRCC4_inactive
type: Protein
entity reference: XRCC4

.ATM.PROMOTES.E2F1.
type: Catalysis
controlled: Phosphorylation.P.ATM.E2F1
xref: 11459832
control type: ACTIVATION
data source: Spike
controller: ATM

.RNF40.PROMOTES.RNF20.
type: Catalysis
controlled: Physical.Interaction.P.RNF40.RNF20
xref: 21362549
control type: ACTIVATION
data source: Spike
controller: RNF40

H2B.family_inactive
type: Protein

FEN1
type: Protein
entity reference: FEN1

http://www.ncbi.nlm.nih.gov/#79648
type: UnificationXref
id: 79648
db: Entrez Gene

EXO1
type: Protein
entity reference: EXO1

18769153
type: PublicationXref
id: 18769153
title: Activation of ATR and related PIKKs
db: PubMed

.UBE2D3.PROMOTES.BRCA1.
type: Catalysis
controlled: Physical.Interaction.P.UBE2D3.BRCA1
xref: 18369654
control type: ACTIVATION
data source: Spike
controller: UBE2D3

HTATIP-UBE2N.complex
type: Complex
name: HTATIP(KAT5)-UBE2N(UBC13)
component: KAT5
component: UBE2N
data source: Spike

RFC.complex_inactive
type: Protein

.ATM.PROMOTES.BRCA1.
type: Catalysis
controlled: Phosphorylation.P.ATM.BRCA1
xref: 11278964
xref: 10550055
control type: ACTIVATION
data source: Spike
controller: ATM

http://www.ncbi.nlm.nih.gov/#55183
type: UnificationXref
id: 55183
db: Entrez Gene

.AURKA.PROMOTES.BRCA1.
type: Catalysis
controlled: Phosphorylation.P.AURKA.BRCA1
xref: 14990569
control type: ACTIVATION
data source: Spike
controller: AURKA

.TOPBP1.PROMOTES.CDC45.
type: Catalysis
controlled: Physical.Interaction.P.TOPBP1.CDC45
xref: 17887956
control type: ACTIVATION
data source: Spike
controller: TOPBP1

10448035
type: PublicationXref
id: 10448035
title: Human Rad51 amino acid residues required for Rad52 binding
db: PubMed

18644834
type: PublicationXref
id: 18644834
title: Early events in the mammalian response to DNA double-strand breaks
db: PubMed

OBFC2B
type: Protein
entity reference: OBFC2B

SMC1A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8243

20348101
type: PublicationXref
id: 20348101
title: Physical interaction of RECQ5 helicase with RAD51 facilitates its anti-recombinase activity
db: PubMed

.ATM.PROMOTES.H2AFX.
type: Catalysis
controlled: Phosphorylation.P.ATM.H2AFX
xref: 18285803
xref: 16531125
control type: ACTIVATION
data source: Spike
controller: ATM

http://www.ncbi.nlm.nih.gov/#1869
type: UnificationXref
id: 1869
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#8318
type: UnificationXref
id: 8318
db: Entrez Gene

15314187
type: PublicationXref
id: 15314187
title: The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair
db: PubMed

Translation
type: MolecularInteraction
participant: RAD51_RNA
participant: RAD51_inactive

.Complex.MRN..RAD50,.NBN,.MRE11A..PROMOTES.RECQL5.
type: Catalysis
controlled: Physical.Interaction.P.MRN.RECQL5
xref: 19270065
control type: ACTIVATION
data source: Spike
controller: MRN.complex

.Complex.MRN..RAD50,.NBN,.MRE11A..PROMOTES.RBBP8.
type: Catalysis
controlled: Physical.Interaction.P.MRN.RBBP8
xref: 17965729
control type: ACTIVATION
data source: Spike
controller: MRN.complex

ATR
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#545

.Complex.SWI/SNF....PROMOTES.TP53.
type: Catalysis
controlled: Other.P.SWI/SNF.TP53
xref: 11950834
control type: ACTIVATION
data source: Spike
controller: SWI/SNF.complex

http://www.ncbi.nlm.nih.gov/#9126
type: UnificationXref
id: 9126
db: Entrez Gene

PADI4
type: Protein
entity reference: PADI4

18066086
type: PublicationXref
id: 18066086
title: Activation and regulation of ATM kinase activity in response to DNA double-strand breaks
db: PubMed

18718915
type: PublicationXref
id: 18718915
title: Microcephalin/MCPH1 associates with the Condensin II complex to function in homologous recombination repair
db: PubMed

UIMC1_inactive
type: Protein
entity reference: UIMC1

http://www.ncbi.nlm.nih.gov/#11200
type: UnificationXref
id: 11200
db: Entrez Gene

FANCD2
type: Protein
entity reference: FANCD2

UBE2N
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7334

CDKN2A
type: Protein
entity reference: CDKN2A

12947101
type: PublicationXref
id: 12947101
title: Cell cycle-dependent phosphorylation of the large subunit of replication factor C (RF-C) leads to its dissociation from the RF-C complex
db: PubMed

18006705
type: PublicationXref
id: 18006705
title: Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase
db: PubMed

PCNA
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5111

Recombinase.complex
type: Complex
name: HR Recombinase complex
component: XRCC3
component: RAD51
component: XRCC2
component: RAD50
component: RAD52
component: RAD54L
data source: Spike

MRE11A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4361

NBN
type: Protein
entity reference: NBN

http://www.ncbi.nlm.nih.gov/#672
type: UnificationXref
id: 672
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#675
type: UnificationXref
id: 675
db: Entrez Gene

TP53_inactive
type: Protein
entity reference: TP53

DNA2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1763

http://www.ncbi.nlm.nih.gov/#9810
type: UnificationXref
id: 9810
db: Entrez Gene

RAD51
type: Protein
entity reference: RAD51

CDC25C
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#995

BRIP1_inactive
type: Protein
entity reference: BRIP1

RNF20
type: Protein
entity reference: RNF20

BRCA1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#672

HP1-BETA-H3K9me.complex_inactive
type: Protein

UPF1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5976

.Complex.RNF20.RNF40..RNF20,.RNF40,.UBE2E1..PROMOTES.Family.H2B...(HIST1H2BJ).
type: Catalysis
controlled: Ubiquitination.P.RNF20.RNF40.H2B
xref: 18614047
control type: ACTIVATION
data source: Spike
controller: RNF20-RNF40.complex

16360315
type: PublicationXref
id: 16360315
title: Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response
db: PubMed

TERF2_inactive
type: Protein
entity reference: TERF2

XRCC1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7515

SMC1A_inactive
type: Protein
entity reference: SMC1A

.ATM.INHIBITS.EXO1.
type: Catalysis
controlled: Phosphorylation.I.ATM.EXO1
xref: 20019063
control type: INHIBITION
data source: Spike
controller: ATM

LIG4
type: Protein
entity reference: LIG4

Translation
type: MolecularInteraction
participant: CDC25C_inactive
participant: CDC25C_RNA

.Complex.Ku.heterodimer.(Ku.70.ku.80)..XRCC5,.XRCC6..PROMOTES.WRN.
type: Catalysis
controlled: Physical.Interaction.P.Ku.heterodimer.(Ku.70.ku.80).WRN
xref: 12919958
xref: 12177300
control type: ACTIVATION
data source: Spike
controller: Ku heterodimer (Ku-70-ku-80).complex

CHEK1_DNA
type: DnaRegion
entity reference: CHEK1

17596542
type: PublicationXref
id: 17596542
title: FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein
db: PubMed

ATM
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#472

RECQL5
type: Protein
entity reference: RECQL5

15468306
type: PublicationXref
id: 15468306
title: Phosphorylation of Artemis following irradiation-induced DNA damage
db: PubMed

.RPA1.PROMOTES.Complex.ATR.ATRIP..ATR,.ATRIP.(ATRIP).
type: Catalysis
controlled: Physical.Interaction.P.RPA1.ATR.ATRIP
xref: 15743907
control type: ACTIVATION
data source: Spike
controller: RPA1

.Complex.FANC(A.B.C.E.F.G.L.M)....PROMOTES.FANCI.
type: Catalysis
controlled: Ubiquitination.P.FANC(A.B.C.E.F.G.L.M).FANCI
xref: 17488615
control type: ACTIVATION
data source: Spike
controller: FANC(A-B-C-E-F-G-L-M).complex

http://www.ncbi.nlm.nih.gov/#641
type: UnificationXref
id: 641
db: Entrez Gene

19481982
type: PublicationXref
id: 19481982
title: 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response
db: PubMed

11459832
type: PublicationXref
id: 11459832
title: Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation
db: PubMed

PRMT1
type: Protein
entity reference: PRMT1

http://www.ncbi.nlm.nih.gov/#10524
type: UnificationXref
id: 10524
db: Entrez Gene

FAM175A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#84142

http://www.ncbi.nlm.nih.gov/#79840
type: UnificationXref
id: 79840
db: Entrez Gene

PhysicalInteraction [PAXIP1 -- TP53BP1 ]
type: MolecularInteraction
xref: 19481982
xref: 19414588
xref: 14576432
participant: TP53BP1
participant: PAXIP1

TOPBP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#11073

UPF1_inactive
type: Protein
entity reference: UPF1

15272308
type: PublicationXref
id: 15272308
title: Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism
db: PubMed

CHEK1
type: Protein
entity reference: CHEK1

15806145
type: PublicationXref
id: 15806145
title: Differences in the association of p53 phosphorylated on serine 15 and key enzymes of homologous recombination
db: PubMed

ACTL6A
type: Protein
entity reference: ACTL6A

.ATM.PROMOTES.RIF1.
type: Catalysis
controlled: Phosphorylation.P.ATM.RIF1
xref: 18077418
xref: 15342490
control type: ACTIVATION
data source: Spike
controller: ATM

HDAC4_inactive
type: Protein
entity reference: HDAC4

http://www.ncbi.nlm.nih.gov/#9656
type: UnificationXref
id: 9656
db: Entrez Gene

SUV420H1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#51111

ATR-ATRIP.complex_inactive
type: Protein

FANC(A-B-C-E-F-G-L-M).complex
type: Complex
name: FANC(A-B-C-E-F-G-L-M)
data source: Spike

TP53
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7157

http://www.ncbi.nlm.nih.gov/#5423
type: UnificationXref
id: 5423
db: Entrez Gene

RAD51_RNA
type: RnaRegion
entity reference: RAD51

18158334
type: PublicationXref
id: 18158334
title: DNA-activated protein kinase functions in a newly observed S phase checkpoint that links histone mRNA abundance with DNA replication
db: PubMed

.KAT5.PROMOTES.Family.H3...(HIST1H3F).
type: Catalysis
controlled: Acetylation.P.KAT5.H3
xref: 10096020
control type: ACTIVATION
data source: Spike
controller: KAT5

http://www.ncbi.nlm.nih.gov/#6790
type: UnificationXref
id: 6790
db: Entrez Gene

17599047
type: PublicationXref
id: 17599047
title: Distinct BRCT domains in Mcph1/Brit1 mediate ionizing radiation-induced focus formation and centrosomal localization
db: PubMed

FACT complex.complex
type: Complex
name: FACT complex [nucleoplasm]
data source: Spike

PhysicalInteraction [BRCA1 -- BRIP1 ]
type: MolecularInteraction
xref: 16713569
xref: 18369654
xref: 14576432
participant: BRCA1
participant: BRIP1

17124166
type: PublicationXref
id: 17124166
title: Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4
db: PubMed

NBN
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4683

TERF2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7014

.TP53BP1.PROMOTES.TP53.
type: Catalysis
controlled: Physical.Interaction.P.TP53BP1.TP53
xref: 17634560
control type: ACTIVATION
data source: Spike
controller: TP53BP1

17923702
type: PublicationXref
id: 17923702
title: DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity
db: PubMed

.PALB2.PROMOTES.BRCA2.
type: Catalysis
controlled: Physical.Interaction.P.PALB2.BRCA2
xref: 17200668
control type: ACTIVATION
data source: Spike
controller: PALB2

http://www.ncbi.nlm.nih.gov/#6117
type: UnificationXref
id: 6117
db: Entrez Gene

17643121
type: PublicationXref
id: 17643121
title: CCDC98 targets BRCA1 to DNA damage sites
db: PubMed

USP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7398

DNMT1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1786

.WRN.PROMOTES.Complex.DNA.Polymerase.delta.tetramer...(POLD4).
type: Catalysis
controlled: Physical.Interaction.P.WRN.DNA.Polymerase.delta.tetramer
xref: 10781066
control type: ACTIVATION
data source: Spike
controller: WRN

.DCLRE1C.PROMOTES.Complex.NHEJ.secondary.complex..NHEJ1,.LIG4,.XRCC4.(XRCC4).
type: Catalysis
controlled: Phosphorylation.P.DCLRE1C.NHEJ.secondary.complex
xref: 16857680
control type: ACTIVATION
data source: Spike
controller: DCLRE1C

.Complex.Gamma.H2AX...MDC1..H2AFX,.MDC1..PROMOTES.BLM.
type: Catalysis
controlled: Other.P.Gamma.H2AX...MDC1.BLM
xref: 18644834
control type: ACTIVATION
data source: Spike
controller: Gamma H2AX - MDC1.complex

FEN1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2237

http://www.ncbi.nlm.nih.gov/#5888
type: UnificationXref
id: 5888
db: Entrez Gene

.Complex.FANC(A.B.C.E.F.G.L.M)....PROMOTES.FANCD2.
type: Catalysis
controlled: Ubiquitination.P.FANC(A.B.C.E.F.G.L.M).FANCD2
xref: 16357213
control type: ACTIVATION
data source: Spike
controller: FANC(A-B-C-E-F-G-L-M).complex

RNF40_inactive
type: Protein
entity reference: RNF40

.TP53BP1.PROMOTES.HDAC4.
type: Catalysis
controlled: Physical.Interaction.P.TP53BP1.HDAC4
xref: 16945145
control type: ACTIVATION
data source: Spike
controller: TP53BP1

http://www.ncbi.nlm.nih.gov/#5884
type: UnificationXref
id: 5884
db: Entrez Gene

RAD17_inactive
type: Protein
entity reference: RAD17

http://www.ncbi.nlm.nih.gov/#4193
type: UnificationXref
id: 4193
db: Entrez Gene

MDM2
type: Protein
entity reference: MDM2

.ATM.PROMOTES.TP53.
type: Catalysis
controlled: Phosphorylation.P.ATM.TP53
xref: 9733515
xref: 9733514
xref: 9843217
control type: ACTIVATION
data source: Spike
controller: ATM

911-complex.complex
type: Complex
name: 911
data source: Spike

http://www.ncbi.nlm.nih.gov/#472
type: UnificationXref
id: 472
db: Entrez Gene

PAXIP1
type: Protein
entity reference: PAXIP1

http://www.ncbi.nlm.nih.gov/#146956
type: UnificationXref
id: 146956
db: Entrez Gene

17942393
type: PublicationXref
id: 17942393
title: Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression
db: PubMed

PhysicalInteraction [Complex FACT complex {} -- Family H2B {} ]
type: MolecularInteraction
xref: 19277046
participant: FACT complex.complex
participant: H2B.family

UIMC1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#51720

15342490
type: PublicationXref
id: 15342490
title: Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint
db: PubMed

XRCC1
type: Protein
entity reference: XRCC1

.RPA1.PROMOTES.FEN1.
type: Catalysis
controlled: Physical.Interaction.P.RPA1.FEN1
xref: 15592449
control type: ACTIVATION
data source: Spike
controller: RPA1

Gamma H2AX - MDC1.complex
type: Complex
name: Gamma H2AX - MDC1
component: MDC1
component: H2AFX
data source: Spike

RIF1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#55183

.RECQL5.INHIBITS.RAD51.
type: Catalysis
controlled: Physical.Interaction.I.RECQL5.RAD51
xref: 20348101
control type: INHIBITION
data source: Spike
controller: RECQL5

CDC25C_DNA
type: DnaRegion
entity reference: CDC25C

Ubc13-Rnf8.complex
type: Complex
name: E3 ligase ube2n-rnf8
component: UBE2N
component: RNF8
data source: Spike

.H2AFX.PROMOTES.MDC1.
type: Catalysis
controlled: Physical.Interaction.P.H2AFX.MDC1
xref: 16427009
control type: ACTIVATION
data source: Spike
controller: H2AFX

.ATM.PROMOTES.CHEK2.
type: Catalysis
controlled: Phosphorylation.P.ATM.CHEK2
xref: 12773400
xref: 9889122
control type: ACTIVATION
data source: Spike
controller: ATM

9109492
type: PublicationXref
id: 9109492
title: Functional interaction between DNA-PK and c-Abl in response to DNA damage
db: PubMed

.KAT5.PROMOTES.Family.H4...(HIST2H4B).
type: Catalysis
controlled: Acetylation.P.KAT5.H4
xref: 10096020
control type: ACTIVATION
data source: Spike
controller: KAT5

.ATM.PROMOTES.SMC1A.
type: Catalysis
controlled: Phosphorylation.P.ATM.SMC1A
xref: 11877376
control type: ACTIVATION
data source: Spike
controller: ATM

17353268
type: PublicationXref
id: 17353268
title: trans Autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining
db: PubMed

NHEJ secondary complex.complex_RNA
type: RnaRegion

http://www.ncbi.nlm.nih.gov/#4683
type: UnificationXref
id: 4683
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#2547
type: UnificationXref
id: 2547
db: Entrez Gene

20019063
type: PublicationXref
id: 20019063
title: Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks
db: PubMed

RPA1
type: Protein
entity reference: RPA1

RECQL
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5965

15686624
type: PublicationXref
id: 15686624
title: Role of c-Abl in the DNA damage stress response
db: PubMed

DNMT1
type: Protein
entity reference: DNMT1

http://www.ncbi.nlm.nih.gov/#8924
type: UnificationXref
id: 8924
db: Entrez Gene

BLM
type: Protein
entity reference: BLM

11950834
type: PublicationXref
id: 11950834
title: SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription
db: PubMed

H2A.family
type: Protein
member physical entity: H2AFX
xref: ELK:F.000026
data source: Spike

H2AFX_inactive
type: Protein
entity reference: H2AFX

OBFC2B_inactive
type: Protein
entity reference: OBFC2B

PRKDC_inactive
type: Protein
entity reference: PRKDC

MLH1
type: Protein
entity reference: MLH1

SMC3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9126

RNF40
type: Protein
entity reference: RNF40

APTX
type: Protein
entity reference: APTX

USP1
type: Protein
entity reference: USP1

14576432
type: PublicationXref
id: 14576432
title: BRCT repeats as phosphopeptide-binding modules involved in protein targeting
db: PubMed

.ATR.PROMOTES.Complex.911.complex...(RAD1).
type: Catalysis
controlled: Phosphorylation.P.ATR.911.complex
xref: 16436514
control type: ACTIVATION
data source: Spike
controller: ATR

15940255
type: PublicationXref
id: 15940255
title: The 'regulatory' beta-subunit of protein kinase CK2 negatively influences p53-mediated allosteric effects on Chk2 activation
db: PubMed

BLM complex.complex
type: Complex
name: Bloom syndrome protein complex
component: BLM
component: RMI1
component: TOP3A
data source: Spike

.E2F1.PROMOTES.CHEK1.
type: TemplateReactionRegulation
controlled: Transcription.Regulation.P.E2F1.CHEK1
xref: 18660752
control type: ACTIVATION
data source: Spike
controller: E2F1

.PADI4.INHIBITS.Family.H4...(HIST2H4B).
type: Catalysis
controlled: Dephosphorylation.I.PADI4.H4
xref: 15345777
control type: INHIBITION
data source: Spike
controller: PADI4

.ATM.PROMOTES.RAD17.
type: Catalysis
controlled: Phosphorylation.P.ATM.RAD17
xref: 11418864
xref: 11687627
control type: ACTIVATION
data source: Spike
controller: ATM

POLB
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5423

.XRCC5.PROMOTES.PRKDC.
type: Catalysis
controlled: Physical.Interaction.P.XRCC5.PRKDC
xref: 18285803
control type: ACTIVATION
data source: Spike
controller: XRCC5

MLH1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4292

H2A.family_inactive
type: Protein

H1.family
type: Protein
xref: CEN:F.329895
data source: Spike

9168116
type: PublicationXref
id: 9168116
title: Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation
db: PubMed

.Complex.911.complex....PROMOTES.TOPBP1.
type: Catalysis
controlled: Physical.Interaction.P.911.complex.TOPBP1
xref: 17636252
control type: ACTIVATION
data source: Spike
controller: 911-complex.complex

11390642
type: PublicationXref
id: 11390642
title: ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
db: PubMed

HP1-BETA-H3K9me.complex
type: Complex
name: HP1-BETA (CBX1)-H3K9me
data source: Spike

http://www.ncbi.nlm.nih.gov/#142
type: UnificationXref
id: 142
db: Entrez Gene

BRCA2
type: Protein
entity reference: BRCA2

.Family.H3....PROMOTES.TP53BP1.
type: Catalysis
controlled: Physical.Interaction.P.H3.TP53BP1
xref: 16774833
control type: ACTIVATION
data source: Spike
controller: H3.family

http://www.ncbi.nlm.nih.gov/#2305
type: UnificationXref
id: 2305
db: Entrez Gene

MDM2_inactive
type: Protein
entity reference: MDM2

CDC45
type: Protein
entity reference: CDC45

11687627
type: PublicationXref
id: 11687627
title: Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage
db: PubMed

WICH.complex
type: Complex
name: WSTFISWI ATP-dependent chromatin-remodelling complex
component: BAZ1B
data source: Spike

EXO1_inactive
type: Protein
entity reference: EXO1

12773400
type: PublicationXref
id: 12773400
title: A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein
db: PubMed

.RPA1.PROMOTES.BRIP1.
type: Catalysis
controlled: Physical.Interaction.P.RPA1.BRIP1
xref: 19419957
xref: 17596542
control type: ACTIVATION
data source: Spike
controller: RPA1

.BARD1.PROMOTES.BRCA1.
type: Catalysis
controlled: Physical.Interaction.P.BARD1.BRCA1
xref: 18369654
control type: ACTIVATION
data source: Spike
controller: BARD1

.TP53.PROMOTES.PADI4.
type: TemplateReactionRegulation
controlled: Transcription.Regulation.P.TP53.PADI4
xref: 19843866
control type: ACTIVATION
data source: Spike
controller: TP53

12919958
type: PublicationXref
id: 12919958
title: ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses
db: PubMed

BLM_inactive
type: Protein
entity reference: BLM

.HSF1.PROMOTES.Complex.DNA.PK..PRKDC,.XRCC6.(PRKDC).
type: Catalysis
controlled: Physical.Interaction.P.HSF1.DNA.PK
xref: 12919958
control type: ACTIVATION
data source: Spike
controller: HSF1

.Complex.RFC....PROMOTES.PCNA.
type: Catalysis
controlled: Physical.Interaction.P.RFC.PCNA
xref: 14530260
control type: ACTIVATION
data source: Spike
controller: RFC.complex

17488615
type: PublicationXref
id: 17488615
title: The Fanconi family adds a fraternal twin
db: PubMed

20639885
type: PublicationXref
id: 20639885
title: The C terminus of p53 binds the N-terminal domain of MDM2
db: PubMed

NHEJ secondary complex.complex_DNA
type: DnaRegion

BRCA2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#675

MCPH1
type: Protein
entity reference: MCPH1

RECQL4
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9401

.PADI4.INHIBITS.Family.H3...(HIST1H3F).
type: Catalysis
controlled: Other.I.PADI4.H3
xref: 15339660
control type: INHIBITION
data source: Spike
controller: PADI4

http://www.ncbi.nlm.nih.gov/#79184
type: UnificationXref
id: 79184
db: Entrez Gene

20376879
type: PublicationXref
id: 20376879
title: Multiple roles of BRIT1/MCPH1 in DNA damage response, DNA repair, and cancer suppression
db: PubMed

http://www.ncbi.nlm.nih.gov/#27343
type: UnificationXref
id: 27343
db: Entrez Gene

RBBP8
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5932

APTX-XRCC4-LIG4.complex
type: Complex
name: APTX-XRCC4-LIG4
component: LIG4
data source: Spike

TOPBP1
type: Protein
entity reference: TOPBP1

18442975
type: PublicationXref
id: 18442975
title: Regulation of intra-S phase checkpoint by ionizing radiation (IR)-dependent and IR-independent phosphorylation of SMC3
db: PubMed

18369654
type: PublicationXref
id: 18369654
title: Recognition of DNA double strand breaks by the BRCA1 tumor suppressor network
db: PubMed

15616588
type: PublicationXref
id: 15616588
title: Nbs1 is required for ATR-dependent phosphorylation events
db: PubMed

ATM_inactive
type: Protein
entity reference: ATM

XRCC4
type: Protein
entity reference: XRCC4

17636252
type: PublicationXref
id: 17636252
title: The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR
db: PubMed

12032095
type: PublicationXref
id: 12032095
title: Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining
db: PubMed

.ATM.INHIBITS.TRIM28.
type: Catalysis
controlled: Phosphorylation.I.ATM.TRIM28
xref: 20424263
xref: 17942393
control type: INHIBITION
data source: Spike
controller: ATM

RAD51_inactive
type: Protein
entity reference: RAD51

XRCC5
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7520

12612651
type: PublicationXref
id: 12612651
title: ATM and related protein kinases: safeguarding genome integrity
db: PubMed

CDC25C_RNA
type: RnaRegion
entity reference: CDC25C

19816404
type: PublicationXref
id: 19816404
title: ATM activates p53 by regulating MDM2 oligomerization and E3 processivity
db: PubMed

HSF1
type: Protein
entity reference: HSF1

17541404
type: PublicationXref
id: 17541404
title: Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1
db: PubMed

.RAD51.PROMOTES.RAD52.
type: Catalysis
controlled: Physical.Interaction.P.RAD51.RAD52
xref: 10448035
control type: ACTIVATION
data source: Spike
controller: RAD51

PhysicalInteraction [RNF168 -- UBE2N ]
type: MolecularInteraction
xref: 18077395
participant: RNF168
participant: UBE2N

.PRKDC.PROMOTES.HERC2.
type: Catalysis
controlled: Phosphorylation.P.PRKDC.HERC2
xref: 20023648
control type: ACTIVATION
data source: Spike
controller: PRKDC

BLM
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#641

16431910
type: PublicationXref
id: 16431910
title: Rapid activation of ATR by ionizing radiation requires ATM and Mre11
db: PubMed

XRCC4
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7518

15190204
type: PublicationXref
id: 15190204
title: ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage
db: PubMed

CHEK1_inactive
type: Protein
entity reference: CHEK1

10550055
type: PublicationXref
id: 10550055
title: Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks
db: PubMed

RNF8
type: Protein
entity reference: RNF8

MDC1
type: Protein
entity reference: MDC1

MDC1_inactive
type: Protein
entity reference: MDC1

9606
type: UnificationXref
id: 9606
db: taxonomy

TRIM28
type: Protein
entity reference: TRIM28

HSF1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3297

UIMC1
type: Protein
entity reference: UIMC1

RAD50
type: Protein
entity reference: RAD50

POLB_inactive
type: Protein
entity reference: POLB

18296440
type: PublicationXref
id: 18296440
title: Preferential dimethylation of histone H4 lysine 20 by Suv4-20
db: PubMed

RECQL5_inactive
type: Protein
entity reference: RECQL5

9560268
type: PublicationXref
id: 9560268
title: The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment
db: PubMed

http://www.ncbi.nlm.nih.gov/#7014
type: UnificationXref
id: 7014
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#55215
type: UnificationXref
id: 55215
db: Entrez Gene

.PRKDC.PROMOTES.PRKDC.
type: Catalysis
controlled: Phosphorylation.P.PRKDC.PRKDC
xref: 17353268
control type: ACTIVATION
data source: Spike
controller: PRKDC

RAD17
type: Protein
entity reference: RAD17

http://www.ncbi.nlm.nih.gov/#1020
type: UnificationXref
id: 1020
db: Entrez Gene

CDC25C
type: Protein
entity reference: CDC25C

http://www.ncbi.nlm.nih.gov/#10111
type: UnificationXref
id: 10111
db: Entrez Gene

19092802
type: PublicationXref
id: 19092802
title: WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity
db: PubMed

.Complex.DNA.PK..PRKDC,.XRCC6..INHIBITS.TRIM28.
type: Catalysis
controlled: Phosphorylation.I.DNA.PK.TRIM28
xref: 19444312
control type: INHIBITION
data source: Spike
controller: DNA-PK.complex

BRCA1_RNA
type: RnaRegion
entity reference: BRCA1

.RNF20.PROMOTES.RNF40.
type: Catalysis
controlled: Physical.Interaction.P.RNF20.RNF40
xref: 21362549
control type: ACTIVATION
data source: Spike
controller: RNF20

http://www.ncbi.nlm.nih.gov/#1029
type: UnificationXref
id: 1029
db: Entrez Gene

9843217
type: PublicationXref
id: 9843217
title: ATM associates with and phosphorylates p53: mapping the region of interaction
db: PubMed

MRN.complex_inactive
type: Protein

CDK5
type: Protein
entity reference: CDK5

PADI4
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#23569

DNA2
type: Protein
entity reference: DNA2

Translation
type: MolecularInteraction
participant: BRCA1_inactive
participant: BRCA1_RNA

LIG4
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3981

21326359
type: PublicationXref
id: 21326359
title: WSTF does it all: a multifunctional protein in transcription, repair, and replication
db: PubMed

CycA-Cdk2.complex
type: Complex
name: CycA-Cdk2
data source: Spike

Condensin II.complex
type: Complex
name: Condensin II
data source: Spike

ATR-ATRIP.complex
type: Complex
name: ATR-ATRIP [nucleoplasm]
component: ATR
component: ATRIP
data source: Spike

HERC2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8924

http://www.ncbi.nlm.nih.gov/#25
type: UnificationXref
id: 25
db: Entrez Gene

FOXM1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2305

.AURKA.INHIBITS.TP53.
type: Catalysis
controlled: Phosphorylation.I.AURKA.TP53
xref: 17259342
control type: INHIBITION
data source: Spike
controller: AURKA

PML
type: Protein
entity reference: PML

PALB2
type: Protein
entity reference: PALB2

SWI/SNF.complex
type: Complex
name: SWI/SNF
data source: Spike

POLM
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#27434

http://www.ncbi.nlm.nih.gov/#51111
type: UnificationXref
id: 51111
db: Entrez Gene

.ATM.INHIBITS.MDM2.
type: Catalysis
controlled: Phosphorylation.I.ATM.MDM2
xref: 19816404
xref: 10611322
control type: INHIBITION
data source: Spike
controller: ATM

14726021
type: PublicationXref
id: 14726021
title: Repair of DNA double strand breaks by non-homologous end joining
db: PubMed

RAD50
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#10111

RNF20-RNF40.complex
type: Complex
name: RNF20-RNF40
component: RNF20
component: RNF40
component: UBE2E1
data source: Spike

E2F1
type: Protein
entity reference: E2F1

17965729
type: PublicationXref
id: 17965729
title: Human CtIP promotes DNA end resection
db: PubMed

.ATR.UNKNOWN.FANCD2.
type: Catalysis
controlled: Phosphorylation.U.ATR.FANCD2
xref: 18082599
xref: 18077418
xref: 15616588
control type: ACTIVATION_UNKMECH
data source: Spike
controller: ATR

RNF2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6045

.USP1.INHIBITS.FANCD2.
type: Catalysis
controlled: Deubiqitination.I.USP1.FANCD2
xref: 16633336
control type: INHIBITION
data source: Spike
controller: USP1

.Complex.Ku.heterodimer.(Ku.70.ku.80)..XRCC5,.XRCC6..PROMOTES.PRKDC.
type: Catalysis
controlled: Physical.Interaction.P.Ku.heterodimer.(Ku.70.ku.80).PRKDC
xref: 17963495
control type: ACTIVATION
data source: Spike
controller: Ku heterodimer (Ku-70-ku-80).complex

.Complex.ARF.MDM2..MDM2,.CDKN2A..PROMOTES.TP53.
type: Catalysis
controlled: Indirect.P.ARF.MDM2.TP53
xref: 16915296
control type: ACTIVATION
data source: Spike
controller: ARF-MDM2.complex

17478428
type: PublicationXref
id: 17478428
title: A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints
db: PubMed

.RNF8.PROMOTES.Family.H2A..H2AFX.(H2AFZ).
type: Catalysis
controlled: Ubiquitination.P.RNF8.H2A
xref: 18001824
xref: 19797077
control type: ACTIVATION
data source: Spike
controller: RNF8

RNF8
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9025

RECQL
type: Protein
entity reference: RECQL

11278964
type: PublicationXref
id: 11278964
title: Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies
db: PubMed

18319725
type: PublicationXref
id: 18319725
title: A comprehensive modular map of molecular interactions in RB/E2F pathway
db: PubMed

18077418
type: PublicationXref
id: 18077418
title: Profiling of UV-induced ATM/ATR signaling pathways
db: PubMed

15339660
type: PublicationXref
id: 15339660
title: Histone deimination antagonizes arginine methylation
db: PubMed

16223874
type: PublicationXref
id: 16223874
title: DNA damage-induced phosphorylation of the human telomere-associated protein TRF2
db: PubMed

.ATM.PROMOTES.Complex.DNA.PK..PRKDC,.XRCC6.(PRKDC).
type: Catalysis
controlled: Phosphorylation.P.ATM.DNA.PK
xref: 17189255
control type: ACTIVATION
data source: Spike
controller: ATM

BRCA2_inactive
type: Protein
entity reference: BRCA2

15386022
type: PublicationXref
id: 15386022
title: Role of histone H2A ubiquitination in Polycomb silencing
db: PubMed

SMC1A
type: Protein
entity reference: SMC1A

PALB2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#79728

.ATM.PROMOTES.TOPBP1.
type: Catalysis
controlled: Phosphorylation.P.ATM.TOPBP1
xref: 19279141
control type: ACTIVATION
data source: Spike
controller: ATM

16904321
type: PublicationXref
id: 16904321
title: Tip60 in DNA damage response and growth control: many tricks in one HAT
db: PubMed

XRCC6
type: Protein
entity reference: XRCC6

RAD51
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5888

.H2AFX.PROMOTES.MCPH1.
type: Catalysis
controlled: Physical.Interaction.P.H2AFX.MCPH1
xref: 17599047
control type: ACTIVATION
data source: Spike
controller: H2AFX

BAZ1B
type: Protein
entity reference: BAZ1B

PRKDC
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5591

16857680
type: PublicationXref
id: 16857680
title: Interplay between Ku, artemis and DNA-PKcs at DNA ends
db: PubMed

17429352
type: PublicationXref
id: 17429352
title: The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex
db: PubMed

CHEK2
type: Protein
entity reference: CHEK2

EME1
type: Protein
entity reference: EME1

NHEJ secondary complex.complex
type: Complex
name: NHEJ secondary complex
component: LIG4
component: NHEJ1
component: XRCC4
data source: Spike

19419957
type: PublicationXref
id: 19419957
title: FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by replication protein A to unwind the damaged DNA substrate in a strand-specific manner
db: PubMed

PAXIP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#22976

BRIP1
type: Protein
entity reference: BRIP1

.ACTL6A.PROMOTES.ATM.
type: Catalysis
controlled: Acetylation.P.ACTL6A.ATM
xref: 16141325
control type: ACTIVATION
data source: Spike
controller: ACTL6A

.Complex.DNA.PK..PRKDC,.XRCC6..PROMOTES.Complex.NHEJ.secondary.complex..NHEJ1,.LIG4,.XRCC4.(XRCC4).
type: Catalysis
controlled: Phosphorylation.P.DNA.PK.NHEJ.secondary.complex
xref: 14726021
control type: ACTIVATION
data source: Spike
controller: DNA-PK.complex

.CHEK1.PROMOTES.RAD51.
type: Catalysis
controlled: Phosphorylation.P.CHEK1.RAD51
xref: 18285803
control type: ACTIVATION
data source: Spike
controller: CHEK1

NuA4.complex_inactive
type: Protein

19797077
type: PublicationXref
id: 19797077
title: Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response
db: PubMed

FOXM1
type: Protein
entity reference: FOXM1

.Complex.911.complex....PROMOTES.POLB.
type: Catalysis
controlled: Physical.Interaction.P.911.complex.POLB
xref: 15314187
control type: ACTIVATION
data source: Spike
controller: 911-complex.complex

15385968
type: PublicationXref
id: 15385968
title: Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV
db: PubMed

http://www.ncbi.nlm.nih.gov/#7398
type: UnificationXref
id: 7398
db: Entrez Gene

.PRMT1.PROMOTES.MRE11A.
type: Catalysis
controlled: Methylation.P.PRMT1.MRE11A
xref: 15741314
control type: ACTIVATION
data source: Spike
controller: PRMT1

20936109
type: PublicationXref
id: 20936109
title: BRCA1 Forms a Functional Complex with -H2AX as a Late Response to Genotoxic Stress
db: PubMed

.CHEK2.PROMOTES.BRCA1.
type: Catalysis
controlled: Phosphorylation.P.CHEK2.BRCA1
xref: 10724175
control type: ACTIVATION
data source: Spike
controller: CHEK2

TP53BP1
type: Protein
entity reference: TP53BP1

16945145
type: PublicationXref
id: 16945145
title: Tying the loose ends together in DNA double strand break repair with 53BP1
db: PubMed

http://www.ncbi.nlm.nih.gov/#5111
type: UnificationXref
id: 5111
db: Entrez Gene

UIMCI-BRCA1-BARD1.complex
type: Complex
name: UIMCI-BRCA1-BARD1-BRCC3
component: FAM175A
component: BRCA1
component: UIMC1
component: BARD1
component: BRCC3
data source: Spike

PARP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#142

FANCI
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#55215

http://www.ncbi.nlm.nih.gov/#1786
type: UnificationXref
id: 1786
db: Entrez Gene

.SUV420H2.PROMOTES.Family.H4...(HIST2H4B).
type: Catalysis
controlled: Methylation.P.SUV420H2.H4
xref: 19218832
control type: ACTIVATION
data source: Spike
controller: SUV420H2

RNF20
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#56254

.Complex.CK2....PROMOTES.TP53.
type: Catalysis
controlled: Phosphorylation.P.CK2.TP53
xref: 15951851
control type: ACTIVATION
data source: Spike
controller: CK2.complex

16009723
type: PublicationXref
id: 16009723
title: Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1
db: PubMed

RPA1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6117

19579266
type: PublicationXref
id: 19579266
title: Efficient activation of p53 pathway in A549 cells exposed to L2, a novel compound targeting p53-MDM2 interaction
db: PubMed

ATRIP
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#84126

http://www.ncbi.nlm.nih.gov/#9025
type: UnificationXref
id: 9025
db: Entrez Gene

.RAD17.PROMOTES.Complex.911.complex...(RAD9A).
type: Catalysis
controlled: Physical.Interaction.P.RAD17.911.complex
xref: 18082599
control type: ACTIVATION
data source: Spike
controller: RAD17

.Complex.Ku.heterodimer.(Ku.70.ku.80)..XRCC5,.XRCC6..PROMOTES.Complex.NHEJ.secondary.complex..NHEJ1,.LIG4,.XRCC4.(NHEJ1).
type: TemplateReactionRegulation
controlled: Transcription.Regulation.P.Ku.heterodimer.(Ku.70.ku.80).NHEJ.secondary.complex
xref: 17124166
control type: ACTIVATION
data source: Spike
controller: Ku heterodimer (Ku-70-ku-80).complex

MCPH1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#79648

19843866
type: PublicationXref
id: 19843866
title: Regulation of protein Citrullination through p53/PADI4 network in DNA damage response
db: PubMed

SHFM1
type: Protein
entity reference: SHFM1

.FOXM1.PROMOTES.BRCA2.
type: TemplateReactionRegulation
controlled: Transcription.Regulation.P.FOXM1.BRCA2
xref: 17101782
control type: ACTIVATION
data source: Spike
controller: FOXM1

17709392
type: PublicationXref
id: 17709392
title: DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics
db: PubMed

E2F1_inactive
type: Protein
entity reference: E2F1

H4.family_inactive
type: Protein

TOP3A
type: Protein
entity reference: TOP3A

17887956
type: PublicationXref
id: 17887956
title: Characterization of the interaction between the human DNA topoisomerase IIbeta-binding protein 1 (TopBP1) and the cell division cycle 45 (Cdc45) protein
db: PubMed

Ku heterodimer (Ku-70-ku-80).complex
type: Complex
name: Ku heterodimer (Ku-70-ku-80) XRCC6-XRCC5
component: XRCC6
component: XRCC5
data source: Spike

17525340
type: PublicationXref
id: 17525340
title: Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response
db: PubMed

http://www.ncbi.nlm.nih.gov/#9031
type: UnificationXref
id: 9031
db: Entrez Gene

CHEK2_inactive
type: Protein
entity reference: CHEK2

11163244
type: PublicationXref
id: 11163244
title: XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair
db: PubMed

18082599
type: PublicationXref
id: 18082599
title: The DNA damage response: ten years after
db: PubMed

10096020
type: PublicationXref
id: 10096020
title: Tip60 acetylates six lysines of a specific class in core histones in vitro
db: PubMed

LIG3
type: Protein
entity reference: LIG3

http://www.ncbi.nlm.nih.gov/#84142
type: UnificationXref
id: 84142
db: Entrez Gene

BAZ1B
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9031

CHEK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1111

RIF1_inactive
type: Protein
entity reference: RIF1

.Complex.CK2....PROMOTES.MDC1.
type: Catalysis
controlled: Phosphorylation.P.CK2.MDC1
xref: 18411307
xref: 18772547
control type: ACTIVATION
data source: Spike
controller: CK2.complex

.WRN.PROMOTES.RAD52.
type: Catalysis
controlled: Physical.Interaction.P.WRN.RAD52
xref: 12919958
control type: ACTIVATION
data source: Spike
controller: WRN

http://www.ncbi.nlm.nih.gov/#84126
type: UnificationXref
id: 84126
db: Entrez Gene

FAM175A
type: Protein
entity reference: FAM175A

http://www.ncbi.nlm.nih.gov/#5371
type: UnificationXref
id: 5371
db: Entrez Gene

.ATM.PROMOTES.MDC1.
type: Catalysis
controlled: Phosphorylation.P.ATM.MDC1
xref: 18006705
control type: ACTIVATION
data source: Spike
controller: ATM

CDKN2A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1029

http://www.ncbi.nlm.nih.gov/#51720
type: UnificationXref
id: 51720
db: Entrez Gene

RFC.complex
type: Complex
name: Replication Factor C
data source: Spike

TERF2
type: Protein
entity reference: TERF2

ATR
type: Protein
entity reference: ATR

POLL
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#27343

TRIM28
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#10155

Translation
type: MolecularInteraction
participant: BRCA2_RNA
participant: BRCA2_inactive

18438399
type: PublicationXref
id: 18438399
title: HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response
db: PubMed

RECQL4
type: Protein
entity reference: RECQL4

UBE2E1
type: Protein
entity reference: UBE2E1

15741314
type: PublicationXref
id: 15741314
title: Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control
db: PubMed

14561766
type: PublicationXref
id: 14561766
title: Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts
db: PubMed

15345777
type: PublicationXref
id: 15345777
title: Human PAD4 regulates histone arginine methylation levels via demethylimination
db: PubMed

.Complex.Gamma.H2AX...MDC1..H2AFX,.MDC1..PROMOTES.Complex.NuA4..KAT5,.ACTL6A.(ACTL6A).
type: Catalysis
controlled: Physical.Interaction.P.Gamma.H2AX...MDC1.NuA4
xref: 16904321
control type: ACTIVATION
data source: Spike
controller: Gamma H2AX - MDC1.complex

UBE2D3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7323

MDM2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4193

http://www.ncbi.nlm.nih.gov/#7158
type: UnificationXref
id: 7158
db: Entrez Gene

MRE11A_inactive
type: Protein
entity reference: MRE11A

http://www.ncbi.nlm.nih.gov/#7157
type: UnificationXref
id: 7157
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#7156
type: UnificationXref
id: 7156
db: Entrez Gene

19277046
type: PublicationXref
id: 19277046
title: The emerging role of nuclear architecture in DNA repair and genome maintenance
db: PubMed

16633336
type: PublicationXref
id: 16633336
title: Regulation of DNA repair by ubiquitylation
db: PubMed

16603769
type: PublicationXref
id: 16603769
title: The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM
db: PubMed

FEN1_inactive
type: Protein
entity reference: FEN1

.Complex.Gamma.H2AX...MDC1..H2AFX,.MDC1..PROMOTES.RNF8.
type: Catalysis
controlled: Physical.Interaction.P.Gamma.H2AX...MDC1.RNF8
xref: 18001824
control type: ACTIVATION
data source: Spike
controller: Gamma H2AX - MDC1.complex

7915517
type: PublicationXref
id: 7915517
title: Transcriptional regulation of the PCNA promoter by p53
db: PubMed

16436514
type: PublicationXref
id: 16436514
title: Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus
db: PubMed

19279141
type: PublicationXref
id: 19279141
title: The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM
db: PubMed

.BAZ1B.PROMOTES.H2AFX.
type: Catalysis
controlled: Phosphorylation.P.BAZ1B.H2AFX
xref: 19092802
xref: 21326359
control type: ACTIVATION
data source: Spike
controller: BAZ1B

20424263
type: PublicationXref
id: 20424263
title: SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1
db: PubMed

http://www.ncbi.nlm.nih.gov/#7979
type: UnificationXref
id: 7979
db: Entrez Gene

.BRCA1.PROMOTES.RBBP8.
type: Catalysis
controlled: Ubiquitination.P.BRCA1.RBBP8
xref: 18369654
control type: ACTIVATION
data source: Spike
controller: BRCA1

.KAT5.PROMOTES.ATM.
type: Catalysis
controlled: Acetylation.P.KAT5.ATM
xref: 16141325
control type: ACTIVATION
data source: Spike
controller: KAT5

.RBBP8.PROMOTES.Complex.MRN..RAD50,.NBN,.MRE11A.(MRE11A).
type: Catalysis
controlled: Physical.Interaction.P.RBBP8.MRN
xref: 17965729
control type: ACTIVATION
data source: Spike
controller: RBBP8

TOP3A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7156

RAD52
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5893

http://www.ncbi.nlm.nih.gov/#10155
type: UnificationXref
id: 10155
db: Entrez Gene

ATM
type: Protein
entity reference: ATM

18519686
type: PublicationXref
id: 18519686
title: RAP80 responds to DNA damage induced by both ionizing radiation and UV irradiation and is phosphorylated at Ser 205
db: PubMed

19151707
type: PublicationXref
id: 19151707
title: Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death
db: PubMed

.XRCC1.PROMOTES.PNKP.
type: Catalysis
controlled: Physical.Interaction.P.XRCC1.PNKP
xref: 11163244
control type: ACTIVATION
data source: Spike
controller: XRCC1

DNA Polymerase delta tetramer.complex
type: Complex
name: DNA Polymerase delta tetramer [nucleoplasm]
data source: Spike

KAT5
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#10524

17189255
type: PublicationXref
id: 17189255
title: Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break
db: PubMed

.SHFM1.PROMOTES.BRCA2.
type: Catalysis
controlled: Physical.Interaction.P.SHFM1.BRCA2
xref: 16205630
control type: ACTIVATION
data source: Spike
controller: SHFM1

http://www.ncbi.nlm.nih.gov/#8438
type: UnificationXref
id: 8438
db: Entrez Gene

DCLRE1C
type: Protein
entity reference: DCLRE1C

.USP1.INHIBITS.FANCI.
type: Catalysis
controlled: Deubiqitination.I.USP1.FANCI
xref: 17488615
control type: INHIBITION
data source: Spike
controller: USP1

.Complex.HTATIP.UBE2N..KAT5,.UBE2N..PROMOTES.H2AFX.
type: Catalysis
controlled: Acetylation.P.HTATIP.UBE2N.H2AFX
xref: 17709392
control type: ACTIVATION
data source: Spike
controller: HTATIP-UBE2N.complex

RIF1
type: Protein
entity reference: RIF1

.Complex.MRN..RAD50,.NBN,.MRE11A..PROMOTES.ATM.
type: Catalysis
controlled: Physical.Interaction.P.MRN.ATM
xref: 18285803
xref: 18066086
control type: ACTIVATION
data source: Spike
controller: MRN.complex

http://www.ncbi.nlm.nih.gov/#1763
type: UnificationXref
id: 1763
db: Entrez Gene

UPF1
type: Protein
entity reference: UPF1

9295282
type: PublicationXref
id: 9295282
title: Inhibition of phosphatidylinositol 3-kinase by c-Abl in the genotoxic stress response
db: PubMed

PADI4_DNA
type: DnaRegion
entity reference: PADI4

15279789
type: PublicationXref
id: 15279789
title: Chk1 in the DNA damage response: conserved roles from yeasts to mammals
db: PubMed

ABL1_inactive
type: Protein
entity reference: ABL1

18411307
type: PublicationXref
id: 18411307
title: Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin
db: PubMed

Homo sapiens
type: BioSource
xref: 9606

APTX
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#54840

http://www.ncbi.nlm.nih.gov/#64421
type: UnificationXref
id: 64421
db: Entrez Gene

.ATM.INHIBITS.UPF1.
type: Catalysis
controlled: Phosphorylation.I.ATM.UPF1
xref: 18158334
control type: INHIBITION
data source: Spike
controller: ATM

PhysicalInteraction [POLL -- XRCC4 ]
type: MolecularInteraction
xref: 14561766
participant: POLL
participant: XRCC4

.Complex.CK2....INHIBITS.Complex.HP1.BETA.H3K9me...(CBX1).
type: Catalysis
controlled: Phosphorylation.I.CK2.HP1.BETA.H3K9me
xref: 18438399
control type: INHIBITION
data source: Spike
controller: CK2.complex

.Complex.CK2....PROMOTES.XRCC1.
type: Catalysis
controlled: Phosphorylation.P.CK2.XRCC1
xref: 11163244
xref: 15066279
control type: ACTIVATION
data source: Spike
controller: CK2.complex

.KAT5.PROMOTES.PRKDC.
type: Catalysis
controlled: Acetylation.P.KAT5.PRKDC
xref: 16603769
control type: ACTIVATION
data source: Spike
controller: KAT5

.ATM.PROMOTES.OBFC2B.
type: Catalysis
controlled: Phosphorylation.P.ATM.OBFC2B
xref: 18449195
control type: ACTIVATION
data source: Spike
controller: ATM

.E2F1.PROMOTES.BRCA1.
type: TemplateReactionRegulation
controlled: Transcription.Regulation.P.E2F1.BRCA1
xref: 18319725
xref: 18660752
control type: ACTIVATION
data source: Spike
controller: E2F1

17101782
type: PublicationXref
id: 17101782
title: Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes
db: PubMed

http://www.ncbi.nlm.nih.gov/#5591
type: UnificationXref
id: 5591
db: Entrez Gene

PhysicalInteraction [BRCA2 -- RAD51 ]
type: MolecularInteraction
comment: intact:EBI-987097,intact:EBI-987144,intact:EBI-987246,intact:EBI-987332,intact:EBI-987396,intact:EBI-297257,intact:EBI-297268,intact:EBI-297231,intact:EBI-298257,intact:EBI-298264
xref: 9560268
xref: 15703751
xref: 17541404
xref: 17145710
participant: BRCA2
participant: RAD51

.TOPBP1.PROMOTES.ATR.
type: Catalysis
controlled: Physical.Interaction.P.TOPBP1.ATR
xref: 18066086
xref: 16285702
xref: 18769153
control type: ACTIVATION
data source: Spike
controller: TOPBP1

14990569
type: PublicationXref
id: 14990569
title: BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition
db: PubMed

17145710
type: PublicationXref
id: 17145710
title: IntAct--open source resource for molecular interaction data
db: PubMed

16357213
type: PublicationXref
id: 16357213
title: The Fanconi Anemia/BRCA pathway: new faces in the crowd
db: PubMed

EME1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#146956

KAT5_inactive
type: Protein
entity reference: KAT5

18449195
type: PublicationXref
id: 18449195
title: Single-stranded DNA-binding protein hSSB1 is critical for genomic stability
db: PubMed

.ATR.PROMOTES.BRCA1.
type: Catalysis
controlled: Phosphorylation.P.ATR.BRCA1
xref: 17478428
xref: 12773400
xref: 20936109
control type: ACTIVATION
data source: Spike
controller: ATR

9733515
type: PublicationXref
id: 9733515
title: Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
db: PubMed

9733514
type: PublicationXref
id: 9733514
title: Enhanced phosphorylation of p53 by ATM in response to DNA damage
db: PubMed

MRE11A
type: Protein
entity reference: MRE11A

15066279
type: PublicationXref
id: 15066279
title: The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks
db: PubMed

BRCA1_DNA
type: DnaRegion
entity reference: BRCA1

XRCC1_inactive
type: Protein
entity reference: XRCC1

http://www.ncbi.nlm.nih.gov/#7515
type: UnificationXref
id: 7515
db: Entrez Gene

15823538
type: PublicationXref
id: 15823538
title: Phosphorylation of histone H4 serine 1 during DNA damage requires casein kinase II in S. cerevisiae
db: PubMed

http://www.ncbi.nlm.nih.gov/#7517
type: UnificationXref
id: 7517
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#7516
type: UnificationXref
id: 7516
db: Entrez Gene

ABL1
type: Protein
entity reference: ABL1

PhysicalInteraction [BLM -- RPA1 ]
type: MolecularInteraction
comment: intact:EBI-621422,intact:EBI-707256,intact:EBI-707269
xref: 18644834
xref: 17145710
xref: 15965237
participant: BLM
participant: RPA1

http://www.ncbi.nlm.nih.gov/#7518
type: UnificationXref
id: 7518
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#86
type: UnificationXref
id: 86
db: Entrez Gene

PNKP
type: Protein
entity reference: PNKP

IMS1 complex..complex
type: Complex
name: INTS3-MISE hSSB1 (IMS1) complex.
component: OBFC2B
data source: Spike

.MDM2.INHIBITS.TP53.
type: Catalysis
controlled: Physical.Interaction.I.MDM2.TP53
xref: 11331603
xref: 20639885
xref: 19579266
control type: INHIBITION
data source: Spike
controller: MDM2

XRCC5
type: Protein
entity reference: XRCC5

18384127
type: PublicationXref
id: 18384127
title: Spatiotemporal dynamics of regulatory protein recruitment at DNA damage sites
db: PubMed

SHFM1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7979

XRCC3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7517

18025084
type: PublicationXref
id: 18025084
title: PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites
db: PubMed

CHEK2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#11200

PhysicalInteraction [Complex FACT complex {} -- Family H2A {H2AFX} ]
type: MolecularInteraction
xref: 19277046
participant: H2A.family
participant: FACT complex.complex

18431400
type: PublicationXref
id: 18431400
title: Transcriptional control of human p53-regulated genes
db: PubMed

http://www.ncbi.nlm.nih.gov/#5976
type: UnificationXref
id: 5976
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#545
type: UnificationXref
id: 545
db: Entrez Gene

MRN.complex
type: Complex
name: MRE11-RAD50-NBS1
component: NBN
component: MRE11A
component: RAD50
data source: Spike

15965237
type: PublicationXref
id: 15965237
title: Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases
db: PubMed

XRCC2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7516

XRCC6
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2547

http://www.ncbi.nlm.nih.gov/#7520
type: UnificationXref
id: 7520
db: Entrez Gene

PNKP
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#11284

http://www.ncbi.nlm.nih.gov/#79728
type: UnificationXref
id: 79728
db: Entrez Gene

11418864
type: PublicationXref
id: 11418864
title: ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses
db: PubMed

.PCNA.PROMOTES.Complex.DNA.Polymerase.delta.tetramer...(POLD4).
type: Catalysis
controlled: Physical.Interaction.P.PCNA.DNA.Polymerase.delta.tetramer
xref: 9038370
control type: ACTIVATION
data source: Spike
controller: PCNA

http://www.ncbi.nlm.nih.gov/#2177
type: UnificationXref
id: 2177
db: Entrez Gene

TP53BP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7158

CycB-Cdc2.complex
type: Complex
name: CyclinB-Cdc2 (CDK1)- M-phase-promoting factor (MPF)
data source: Spike

.Complex.Gamma.H2AX...MDC1..H2AFX,.MDC1..PROMOTES.NBN.
type: Catalysis
controlled: Physical.Interaction.P.Gamma.H2AX...MDC1.NBN
xref: 17963495
control type: ACTIVATION
data source: Spike
controller: Gamma H2AX - MDC1.complex

CK2.complex
type: Complex
name: Caseine Kinase 2
data source: Spike

POLL
type: Protein
entity reference: POLL

TOPBP1_inactive
type: Protein
entity reference: TOPBP1

http://www.ncbi.nlm.nih.gov/#5965
type: UnificationXref
id: 5965
db: Entrez Gene

HDAC4
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9759

Translation
type: MolecularInteraction
participant: CHEK1_RNA
participant: CHEK1_inactive

16285702
type: PublicationXref
id: 16285702
title: ATR-FT-IR membrane-based sensor for integrated microliquid-liquid extraction and detection
db: PubMed

H2B.family
type: Protein
xref: ELK:F.000027
data source: Spike

Spike
type: Provenance

16205630
type: PublicationXref
id: 16205630
title: DSS1 is required for the stability of BRCA2
db: PubMed

FANCI_inactive
type: Protein
entity reference: FANCI

RAD17
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5884

http://www.ncbi.nlm.nih.gov/#995
type: UnificationXref
id: 995
db: Entrez Gene

DCLRE1C_inactive
type: Protein
entity reference: DCLRE1C

H2AFX
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3014

15743907
type: PublicationXref
id: 15743907
title: ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation
db: PubMed

.CHEK2.INHIBITS.CDC25C.
type: Catalysis
controlled: Phosphorylation.I.CHEK2.CDC25C
xref: 10681541
control type: INHIBITION
data source: Spike
controller: CHEK2

16915296
type: PublicationXref
id: 16915296
title: Divorcing ARF and p53: an unsettled case
db: PubMed

POLM
type: Protein
entity reference: POLM

21362549
type: PublicationXref
id: 21362549
title: Requirement of ATM-Dependent Monoubiquitylation of Histone H2B for Timely Repair of DNA Double-Strand Breaks
db: PubMed

H3.family
type: Protein
xref: ELK:F.000028
data source: Spike

RECQL5
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9400

15592449
type: PublicationXref
id: 15592449
title: Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks
db: PubMed

911-complex.complex_inactive
type: Protein

10724175
type: PublicationXref
id: 10724175
title: hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
db: PubMed

18614047
type: PublicationXref
id: 18614047
title: H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation
db: PubMed

.ATM.PROMOTES.DCLRE1C.
type: Catalysis
controlled: Phosphorylation.P.ATM.DCLRE1C
xref: 15468306
xref: 15456891
control type: ACTIVATION
data source: Spike
controller: ATM

PhysicalInteraction [BLM -- RAD51 ]
type: MolecularInteraction
xref: 11278509
participant: RAD51
participant: BLM

BARD1
type: Protein
entity reference: BARD1

http://www.ncbi.nlm.nih.gov/#4292
type: UnificationXref
id: 4292
db: Entrez Gene

.TP53.PROMOTES.PCNA.
type: TemplateReactionRegulation
controlled: Transcription.Regulation.P.TP53.PCNA
xref: 7915517
control type: ACTIVATION
data source: Spike
controller: TP53

.XRCC4.PROMOTES.PNKP.
type: Catalysis
controlled: Other.P.XRCC4.PNKP
xref: 12032095
control type: ACTIVATION
data source: Spike
controller: XRCC4

DNA-PK.complex
type: Complex
name: DNA-PK
component: XRCC6
component: PRKDC
data source: Spike

10611322
type: PublicationXref
id: 10611322
title: Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage.
db: PubMed

ssDNA-RPA.complex
type: Complex
name: single stranded DNA
data source: Spike

17259342
type: PublicationXref
id: 17259342
title: Roles of Aurora kinases in mitosis and tumorigenesis
db: PubMed

http://www.ncbi.nlm.nih.gov/#580
type: UnificationXref
id: 580
db: Entrez Gene

.Complex.CK2....PROMOTES.XRCC4.
type: Catalysis
controlled: Phosphorylation.P.CK2.XRCC4
xref: 15385968
control type: ACTIVATION
data source: Spike
controller: CK2.complex

12177300
type: PublicationXref
id: 12177300
title: Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus
db: PubMed

http://www.ncbi.nlm.nih.gov/#5932
type: UnificationXref
id: 5932
db: Entrez Gene

RNF168
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#165918

http://www.ncbi.nlm.nih.gov/#9759
type: UnificationXref
id: 9759
db: Entrez Gene

PhysicalInteraction [TP53 -- TP53BP1 ]
type: MolecularInteraction
xref: 16713569
xref: 17634560
participant: TP53BP1
participant: TP53

SUV420H2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#84787

17963495
type: PublicationXref
id: 17963495
title: Extensive ssDNA end formation at DNA double-strand breaks in non-homologous end-joining deficient cells during the S phase
db: PubMed

H3.family_inactive
type: Protein

RAD52_inactive
type: Protein
entity reference: RAD52

PCNA_RNA
type: RnaRegion
entity reference: PCNA

.ABL1.INHIBITS.Complex.DNA.PK..PRKDC,.XRCC6.(PRKDC).
type: Catalysis
controlled: Phosphorylation.I.ABL1.DNA.PK
xref: 15686624
xref: 9295282
xref: 9109492
control type: INHIBITION
data source: Spike
controller: ABL1

19444312
type: PublicationXref
id: 19444312
title: Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells
db: PubMed

.Complex.CK2....INHIBITS.CDC25C.
type: Catalysis
controlled: Phosphorylation.I.CK2.CDC25C
xref: 15940255
control type: INHIBITION
data source: Spike
controller: CK2.complex

9889122
type: PublicationXref
id: 9889122
title: A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
db: PubMed

NuA4.complex
type: Complex
name: NuA4/Tip60 HAT complex
component: KAT5
component: ACTL6A
data source: Spike

http://www.ncbi.nlm.nih.gov/#11073
type: UnificationXref
id: 11073
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#27434
type: UnificationXref
id: 27434
db: Entrez Gene

PCNA_inactive
type: Protein
entity reference: PCNA

MDC1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9656

BRCA1
type: Protein
entity reference: BRCA1

CDC25C_inactive
type: Protein
entity reference: CDC25C

KAT5
type: Protein
entity reference: KAT5

18285803
type: PublicationXref
id: 18285803
title: Regulation of DNA repair throughout the cell cycle
db: PubMed

SUV420H1
type: Protein
entity reference: SUV420H1

RAD51_DNA
type: DnaRegion
entity reference: RAD51

.RAD52.PROMOTES.RAD51.
type: Catalysis
controlled: Physical.Interaction.P.RAD52.RAD51
xref: 10448035
control type: ACTIVATION
data source: Spike
controller: RAD52

DNA-PK.complex_inactive
type: Protein

TP53
type: Protein
entity reference: TP53

.ATR.PROMOTES.CHEK1.
type: Catalysis
controlled: Phosphorylation.P.ATR.CHEK1
xref: 16431910
xref: 15279789
xref: 12766152
xref: 12781359
xref: 15190204
xref: 15272308
xref: 10859164
xref: 10859163
xref: 16360315
xref: 11090622
xref: 11390642
control type: ACTIVATION
data source: Spike
controller: ATR

http://www.ncbi.nlm.nih.gov/#8243
type: UnificationXref
id: 8243
db: Entrez Gene

17991895
type: PublicationXref
id: 17991895
title: DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B
db: PubMed

ELK:F.000026
type: UnificationXref
id: ELK:F-000026
db: Spike DB

10781066
type: PublicationXref
id: 10781066
title: Functional interaction between the Werner Syndrome protein and DNA polymerase delta
db: PubMed

.PARP1.PROMOTES.ATM.
type: Catalysis
controlled: Phosphorylation.P.PARP1.ATM
xref: 17459151
xref: 18025084
control type: ACTIVATION
data source: Spike
controller: PARP1

ELK:F.000028
type: UnificationXref
id: ELK:F-000028
db: Spike DB

ELK:F.000027
type: UnificationXref
id: ELK:F-000027
db: Spike DB

http://www.ncbi.nlm.nih.gov/#4361
type: UnificationXref
id: 4361
db: Entrez Gene

POLB
type: Protein
entity reference: POLB

ELK:F.000029
type: UnificationXref
id: ELK:F-000029
db: Spike DB

BRCA2_DNA
type: DnaRegion
entity reference: BRCA2

11331603
type: PublicationXref
id: 11331603
title: ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage
db: PubMed

.MDC1.PROMOTES.TP53BP1.
type: Catalysis
controlled: Physical.Interaction.P.MDC1.TP53BP1
xref: 16009723
control type: ACTIVATION
data source: Spike
controller: MDC1

.Complex.CycB.Cdc2....INHIBITS.BRCA2.
type: Catalysis
controlled: Phosphorylation.I.CycB.Cdc2.BRCA2
xref: 15800615
control type: INHIBITION
data source: Spike
controller: CycB-Cdc2.complex

.PCNA.PROMOTES.DNMT1.
type: Catalysis
controlled: Physical.Interaction.P.PCNA.DNMT1
xref: 18384127
xref: 17991895
control type: ACTIVATION
data source: Spike
controller: PCNA

http://www.ncbi.nlm.nih.gov/#2237
type: UnificationXref
id: 2237
db: Entrez Gene

Cohesin.complex
type: Complex
name: Cohesin (mytotic)
component: SMC1A
component: SMC3
data source: Spike

15800615
type: PublicationXref
id: 15800615
title: CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair
db: PubMed

.Complex.DNA.PK..PRKDC,.XRCC6..PROMOTES.DCLRE1C.
type: Catalysis
controlled: Phosphorylation.P.DNA.PK.DCLRE1C
xref: 14726021
control type: ACTIVATION
data source: Spike
controller: DNA-PK.complex

RAD54L
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8438

16141325
type: PublicationXref
id: 16141325
title: A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM
db: PubMed

RNF40
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9810

DNMT1_inactive
type: Protein
entity reference: DNMT1

16713569
type: PublicationXref
id: 16713569
title: A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
db: PubMed

CHEK1_RNA
type: RnaRegion
entity reference: CHEK1

.Complex.CycA.Cdk2....INHIBITS.BRCA2.
type: Catalysis
controlled: Phosphorylation.I.CycA.Cdk2.BRCA2
xref: 15800615
control type: INHIBITION
data source: Spike
controller: CycA-Cdk2.complex

RBBP8
type: Protein
entity reference: RBBP8

.ATR.PROMOTES.UIMC1.
type: Catalysis
controlled: Phosphorylation.P.ATR.UIMC1
xref: 18519686
control type: ACTIVATION
data source: Spike
controller: ATR

http://www.ncbi.nlm.nih.gov/#54840
type: UnificationXref
id: 54840
db: Entrez Gene

10681541
type: PublicationXref
id: 10681541
title: The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01
db: PubMed

DNA Polymerase delta tetramer.complex_inactive
type: Protein

CDC45
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#8318

.CHEK1.INHIBITS.CDC25C.
type: Catalysis
controlled: Phosphorylation.I.CHEK1.CDC25C
xref: 10681541
control type: INHIBITION
data source: Spike
controller: CHEK1

.SUV420H1.PROMOTES.Family.H4...(HIST2H4B).
type: Catalysis
controlled: Methylation.P.SUV420H1.H4
xref: 19218832
control type: ACTIVATION
data source: Spike
controller: SUV420H1

.ATR.PROMOTES.RAD17.
type: Catalysis
controlled: Phosphorylation.P.ATR.RAD17
xref: 11418864
control type: ACTIVATION
data source: Spike
controller: ATR

.KAT5.PROMOTES.Family.H2A..H2AFX.(H2AFZ).
type: Catalysis
controlled: Acetylation.P.KAT5.H2A
xref: 10096020
control type: ACTIVATION
data source: Spike
controller: KAT5

18443409
type: PublicationXref
id: 18443409
title: New players in the BRCA1-mediated DNA damage responsive pathway
db: PubMed

DCLRE1C
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#64421

.Complex.NuA4..KAT5,.ACTL6A..PROMOTES.ATM.
type: Catalysis
controlled: Acetylation.P.NuA4.ATM
xref: 17923702
control type: ACTIVATION
data source: Spike
controller: NuA4.complex

19218832
type: PublicationXref
id: 19218832
title: Chromatin dynamics coupled to DNA repair
db: PubMed

.PARP1.PROMOTES.MRE11A.
type: Catalysis
controlled: Physical.Interaction.P.PARP1.MRE11A
xref: 18025084
control type: ACTIVATION
data source: Spike
controller: PARP1

BASC.complex
type: Complex
name: BRCA-1-associated genome surveillance complex
component: NBN
component: ATM
component: BRCA1
component: MRE11A
component: RAD50
component: BLM
component: MLH1
data source: Spike

TP53BP1_inactive
type: Protein
entity reference: TP53BP1

SUV420H2
type: Protein
entity reference: SUV420H2

http://www.ncbi.nlm.nih.gov/#5893
type: UnificationXref
id: 5893
db: Entrez Gene

11877376
type: PublicationXref
id: 11877376
title: Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage
db: PubMed

FANCD2_inactive
type: Protein
entity reference: FANCD2

PADI4_RNA
type: RnaRegion
entity reference: PADI4

TRIM28_inactive
type: Protein
entity reference: TRIM28

BARD1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#580

.H2AFX.PROMOTES.TP53BP1.
type: Catalysis
controlled: Physical.Interaction.P.H2AFX.TP53BP1
xref: 12697768
control type: ACTIVATION
data source: Spike
controller: H2AFX

BRIP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#83990

UBE2D3
type: Protein
entity reference: UBE2D3

RNF2
type: Protein
entity reference: RNF2

APTX-XRCC1-LIG3.complex
type: Complex
name: APTX-XRCC1-LIG3
component: LIG3
component: XRCC1
component: APTX
data source: Spike

FANCD2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2177

http://www.ncbi.nlm.nih.gov/#6045
type: UnificationXref
id: 6045
db: Entrez Gene

15703751
type: PublicationXref
id: 15703751
title: The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction
db: PubMed

14530260
type: PublicationXref
id: 14530260
title: Replication factor C clamp loader subunit arrangement within the circular pentamer and its attachment points to proliferating cell nuclear antigen
db: PubMed

PRMT1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3276

BRCC3
type: Protein
entity reference: BRCC3

NHEJ1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#79840

E2F1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1869

PNKP_inactive
type: Protein
entity reference: PNKP

http://www.ncbi.nlm.nih.gov/#22976
type: UnificationXref
id: 22976
db: Entrez Gene

PhysicalInteraction [ATM -- NBN ]
type: MolecularInteraction
xref: 17429352
participant: NBN
participant: ATM

http://www.ncbi.nlm.nih.gov/#1111
type: UnificationXref
id: 1111
db: Entrez Gene

11090622
type: PublicationXref
id: 11090622
title: Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts
db: PubMed

.RNF168.PROMOTES.Family.H2A..H2AFX.(H2AFX).
type: Catalysis
controlled: Ubiquitination.P.RNF168.H2A
xref: 18443409
control type: ACTIVATION
data source: Spike
controller: RNF168

NBN_inactive
type: Protein
entity reference: NBN

http://www.ncbi.nlm.nih.gov/#7324
type: UnificationXref
id: 7324
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#7323
type: UnificationXref
id: 7323
db: Entrez Gene

20023648
type: PublicationXref
id: 20023648
title: HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes
db: PubMed

http://www.ncbi.nlm.nih.gov/#23569
type: UnificationXref
id: 23569
db: Entrez Gene

SMC3_inactive
type: Protein
entity reference: SMC3

15456891
type: PublicationXref
id: 15456891
title: Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response
db: PubMed

Translation
type: MolecularInteraction
participant: NHEJ secondary complex.complex_inactive
participant: NHEJ secondary complex.complex_RNA

PRKDC
type: Protein
entity reference: PRKDC

WRN_inactive
type: Protein
entity reference: WRN

18001824
type: PublicationXref
id: 18001824
title: RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
db: PubMed

.ATM.PROMOTES.TERF2.
type: Catalysis
controlled: Phosphorylation.P.ATM.TERF2
xref: 16223874
control type: ACTIVATION
data source: Spike
controller: ATM

LIG3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3980

BRCA1_inactive
type: Protein
entity reference: BRCA1

MCPH1_inactive
type: Protein
entity reference: MCPH1

RAD52
type: Protein
entity reference: RAD52

HDAC4
type: Protein
entity reference: HDAC4

NHEJ secondary complex.complex_inactive
type: Protein

http://www.ncbi.nlm.nih.gov/#56254
type: UnificationXref
id: 56254
db: Entrez Gene

18077395
type: PublicationXref
id: 18077395
title: Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage
db: PubMed

.RNF2.INHIBITS.Family.H2A..H2AFX.(H2AFZ).
type: Catalysis
controlled: Ubiquitination.I.RNF2.H2A
xref: 15386022
control type: INHIBITION
data source: Spike
controller: RNF2

RecQ-like helicases.family
type: Protein
member physical entity: WRN
member physical entity: RECQL
member physical entity: RECQL5
member physical entity: RECQL4
member physical entity: BLM
xref: CEN:F.329888
data source: Spike

http://www.ncbi.nlm.nih.gov/#3981
type: UnificationXref
id: 3981
db: Entrez Gene

OBFC2B
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#79035

RMI1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#80010

PCNA_DNA
type: DnaRegion
entity reference: PCNA

http://www.ncbi.nlm.nih.gov/#84787
type: UnificationXref
id: 84787
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#3980
type: UnificationXref
id: 3980
db: Entrez Gene

PhysicalInteraction [BRCA1 -- FAM175A ]
type: MolecularInteraction
xref: 17525340
xref: 17643121
participant: FAM175A
participant: BRCA1

XRCC3
type: Protein
entity reference: XRCC3

FANCD2-BRCA2.complex
type: Complex
name: FANCD2-BRCA2
component: FANCD2
component: BRCA2
data source: Spike

16774833
type: PublicationXref
id: 16774833
title: The ATM-mediated DNA-damage response: taking shape
db: PubMed

http://www.ncbi.nlm.nih.gov/#7334
type: UnificationXref
id: 7334
db: Entrez Gene

.Family.H4....PROMOTES.TP53BP1.
type: Catalysis
controlled: Physical.Interaction.P.H4.TP53BP1
xref: 19218832
xref: 18296440
control type: ACTIVATION
data source: Spike
controller: H4.family

PML
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5371

.MDC1.PROMOTES.RNF8.
type: Catalysis
controlled: Indirect.P.MDC1.RNF8
xref: 18001824
control type: ACTIVATION
data source: Spike
controller: MDC1

HERC2_inactive
type: Protein
entity reference: HERC2

PhysicalInteraction [Complex Condensin II {} -- MCPH1 ]
type: MolecularInteraction
xref: 20376879
xref: 18718915
participant: MCPH1
participant: Condensin II.complex

CEN:F.329895
type: UnificationXref
id: CEN:F-329895
db: Spike DB

CDC45_inactive
type: Protein
entity reference: CDC45

.BLM.PROMOTES.TP53.
type: Catalysis
controlled: Physical.Interaction.P.BLM.TP53
xref: 15806145
control type: ACTIVATION
data source: Spike
controller: BLM

http://www.ncbi.nlm.nih.gov/#3297
type: UnificationXref
id: 3297
db: Entrez Gene

CDK5
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1020

.Complex.ssDNA.RPA..ssDNA..PROMOTES.RAD17.
type: Catalysis
controlled: Physical.Interaction.P.ssDNA.RPA.RAD17
xref: 18082599
control type: ACTIVATION
data source: Spike
controller: ssDNA-RPA.complex

http://www.ncbi.nlm.nih.gov/#80010
type: UnificationXref
id: 80010
db: Entrez Gene

PCNA
type: Protein
entity reference: PCNA

http://www.ncbi.nlm.nih.gov/#3014
type: UnificationXref
id: 3014
db: Entrez Gene

UBE2E1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7324

ARF-MDM2.complex
type: Complex
name: ARF-MDM2
component: MDM2
component: CDKN2A
data source: Spike

14966270
type: PublicationXref
id: 14966270
title: Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans
db: PubMed

12781359
type: PublicationXref
id: 12781359
title: Chk1 and Chk2 kinases in checkpoint control and cancer
db: PubMed

BRCC3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#79184

WRN-LIG3.complex
type: Complex
name: WRN-LIG3
component: LIG3
data source: Spike

RNF168
type: Protein
entity reference: RNF168

.ATM.PROMOTES.SMC3.
type: Catalysis
controlled: Phosphorylation.P.ATM.SMC3
xref: 18442975
control type: ACTIVATION
data source: Spike
controller: ATM

CEN:F.329888
type: UnificationXref
id: CEN:F-329888
db: Spike DB

XRCC2
type: Protein
entity reference: XRCC2

ATR_inactive
type: Protein
entity reference: ATR

19414588
type: PublicationXref
id: 19414588
title: PTIP Regulates 53BP1 and SMC1 at the DNA Damage Sites
db: PubMed

RBBP8_inactive
type: Protein
entity reference: RBBP8

.Complex.CK2....INHIBITS.Family.H4...(HIST2H4B).
type: Catalysis
controlled: Phosphorylation.I.CK2.H4
xref: 15823538
control type: INHIBITION
data source: Spike
controller: CK2.complex

RAD54L
type: Protein
entity reference: RAD54L

H2AFX
type: Protein
entity reference: H2AFX

.PRKDC.INHIBITS.UPF1.
type: Catalysis
controlled: Phosphorylation.I.PRKDC.UPF1
xref: 18158334
control type: INHIBITION
data source: Spike
controller: PRKDC

.CDK5.PROMOTES.ATM.
type: Catalysis
controlled: Phosphorylation.P.CDK5.ATM
xref: 19151707
control type: ACTIVATION
data source: Spike
controller: CDK5

H4.family
type: Protein
xref: ELK:F.000029
data source: Spike

17459151
type: PublicationXref
id: 17459151
title: Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition
db: PubMed

17200668
type: PublicationXref
id: 17200668
title: PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene
db: PubMed

.TP53.INHIBITS.CDC25C.
type: TemplateReactionRegulation
controlled: Transcription.Regulation.I.TP53.CDC25C
xref: 18431400
control type: INHIBITION
data source: Spike
controller: TP53

17218262
type: PublicationXref
id: 17218262
title: Essential role for nuclear PTEN in maintaining chromosomal integrity
db: PubMed

FANCI
type: Protein
entity reference: FANCI

.ATM.PROMOTES.FANCD2.
type: Catalysis
controlled: Phosphorylation.P.ATM.FANCD2
xref: 12612651
control type: ACTIVATION
data source: Spike
controller: ATM

ACTL6A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#86

PARP1
type: Protein
entity reference: PARP1

ABL1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#25

.Complex.Ku.heterodimer.(Ku.70.ku.80)..XRCC5,.XRCC6..PROMOTES.XRCC4.
type: Catalysis
controlled: Physical.Interaction.P.Ku.heterodimer.(Ku.70.ku.80).XRCC4
xref: 17124166
control type: ACTIVATION
data source: Spike
controller: Ku heterodimer (Ku-70-ku-80).complex

http://www.ncbi.nlm.nih.gov/#3276
type: UnificationXref
id: 3276
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#11284
type: UnificationXref
id: 11284
db: Entrez Gene

18660752
type: PublicationXref
id: 18660752
title: MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis
db: PubMed

RNF20_inactive
type: Protein
entity reference: RNF20

12697768
type: PublicationXref
id: 12697768
title: Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX
db: PubMed

18772547
type: PublicationXref
id: 18772547
title: Dancing on damaged chromatin: functions of ATM and the RAD50/MRE11/NBS1 complex in cellular responses to DNA damage
db: PubMed

12766152
type: PublicationXref
id: 12766152
title: Human claspin is required for replication checkpoint control
db: PubMed

Translation
type: MolecularInteraction
participant: PADI4_RNA
participant: PADI4

.MDM2.INHIBITS.KAT5.
type: Catalysis
controlled: Physical.Interaction.I.MDM2.KAT5
xref: 16904321
control type: INHIBITION
data source: Spike
controller: MDM2

16531125
type: PublicationXref
id: 16531125
title: gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes
db: PubMed