PCNA: structure, functions and interactions
The multiple personalities of the regulatory subunit of protein kinase CK2: CK2 dependent and CK2 independent roles reveal a secret identity for CK2beta
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals
Polymorphic TP53BP1 and TP53 gene interactions associated with risk of squamous cell carcinoma of the head and neck
MRE11 complex links RECQ5 helicase to sites of DNA damage
Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51
Human Rad51 amino acid residues required for Rad52 binding
Early events in the mammalian response to DNA double-strand breaks
Physical interaction of RECQ5 helicase with RAD51 facilitates its anti-recombinase activity
The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair
Activation and regulation of ATM kinase activity in response to DNA double-strand breaks
Microcephalin/MCPH1 associates with the Condensin II complex to function in homologous recombination repair
Cell cycle-dependent phosphorylation of the large subunit of replication factor C (RF-C) leads to its dissociation from the RF-C complex
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase
Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response
FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein
Phosphorylation of Artemis following irradiation-induced DNA damage
14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response
Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation
PhysicalInteraction [PAXIP1 -- TP53BP1 ]
Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism
Differences in the association of p53 phosphorylated on serine 15 and key enzymes of homologous recombination
DNA-activated protein kinase functions in a newly observed S phase checkpoint that links histone mRNA abundance with DNA replication
Distinct BRCT domains in Mcph1/Brit1 mediate ionizing radiation-induced focus formation and centrosomal localization
Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4
DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity
CCDC98 targets BRCA1 to DNA damage sites
Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression
PhysicalInteraction [Complex FACT complex {} -- Family H2B {} ]
Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint
Functional interaction between DNA-PK and c-Abl in response to DNA damage
trans Autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining
Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks
Role of c-Abl in the DNA damage stress response
SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription
BRCT repeats as phosphopeptide-binding modules involved in protein targeting
The 'regulatory' beta-subunit of protein kinase CK2 negatively influences p53-mediated allosteric effects on Chk2 activation
Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage
WSTFISWI ATP-dependent chromatin-remodelling complex
A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein
ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses
The Fanconi family adds a fraternal twin
The C terminus of p53 binds the N-terminal domain of MDM2
Multiple roles of BRIT1/MCPH1 in DNA damage response, DNA repair, and cancer suppression
Regulation of intra-S phase checkpoint by ionizing radiation (IR)-dependent and IR-independent phosphorylation of SMC3
Recognition of DNA double strand breaks by the BRCA1 tumor suppressor network
Nbs1 is required for ATR-dependent phosphorylation events
The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR
Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining
ATM and related protein kinases: safeguarding genome integrity
ATM activates p53 by regulating MDM2 oligomerization and E3 processivity
Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1
Rapid activation of ATR by ionizing radiation requires ATM and Mre11
ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks
Preferential dimethylation of histone H4 lysine 20 by Suv4-20
The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment
WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity
ATM associates with and phosphorylates p53: mapping the region of interaction
WSTF does it all: a multifunctional protein in transcription, repair, and replication
Repair of DNA double strand breaks by non-homologous end joining
A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints
Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies
A comprehensive modular map of molecular interactions in RB/E2F pathway
Profiling of UV-induced ATM/ATR signaling pathways
Histone deimination antagonizes arginine methylation
DNA damage-induced phosphorylation of the human telomere-associated protein TRF2
Role of histone H2A ubiquitination in Polycomb silencing
Tip60 in DNA damage response and growth control: many tricks in one HAT
Interplay between Ku, artemis and DNA-PKcs at DNA ends
The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex
FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by replication protein A to unwind the damaged DNA substrate in a strand-specific manner
Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response
Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV
BRCA1 Forms a Functional Complex with -H2AX as a Late Response to Genotoxic Stress
Tying the loose ends together in DNA double strand break repair with 53BP1
Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1
Efficient activation of p53 pathway in A549 cells exposed to L2, a novel compound targeting p53-MDM2 interaction
Regulation of protein Citrullination through p53/PADI4 network in DNA damage response
DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics
Characterization of the interaction between the human DNA topoisomerase IIbeta-binding protein 1 (TopBP1) and the cell division cycle 45 (Cdc45) protein
Ku heterodimer (Ku-70-ku-80) XRCC6-XRCC5
Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response
XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair
The DNA damage response: ten years after
Tip60 acetylates six lysines of a specific class in core histones in vitro
HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response
Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control
Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts
Human PAD4 regulates histone arginine methylation levels via demethylimination
The emerging role of nuclear architecture in DNA repair and genome maintenance
Regulation of DNA repair by ubiquitylation
The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM
Transcriptional regulation of the PCNA promoter by p53
Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus
The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM
SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1
RAP80 responds to DNA damage induced by both ionizing radiation and UV irradiation and is phosphorylated at Ser 205
Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death
DNA Polymerase delta tetramer [nucleoplasm]
Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break
Inhibition of phosphatidylinositol 3-kinase by c-Abl in the genotoxic stress response
Chk1 in the DNA damage response: conserved roles from yeasts to mammals
Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin
Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes
BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition
IntAct--open source resource for molecular interaction data
The Fanconi Anemia/BRCA pathway: new faces in the crowd
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
Enhanced phosphorylation of p53 by ATM in response to DNA damage
The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks
Phosphorylation of histone H4 serine 1 during DNA damage requires casein kinase II in S. cerevisiae
Spatiotemporal dynamics of regulatory protein recruitment at DNA damage sites
PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites
PhysicalInteraction [Complex FACT complex {} -- Family H2A {H2AFX} ]
Transcriptional control of human p53-regulated genes
Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases
ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses
CyclinB-Cdc2 (CDK1)- M-phase-promoting factor (MPF)
ATR-FT-IR membrane-based sensor for integrated microliquid-liquid extraction and detection
DSS1 is required for the stability of BRCA2
ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation
Divorcing ARF and p53: an unsettled case
Requirement of ATM-Dependent Monoubiquitylation of Histone H2B for Timely Repair of DNA Double-Strand Breaks
Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks
hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation
Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage.
Roles of Aurora kinases in mitosis and tumorigenesis
Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus
Extensive ssDNA end formation at DNA double-strand breaks in non-homologous end-joining deficient cells during the S phase
Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
Regulation of DNA repair throughout the cell cycle
DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B
Functional interaction between the Werner Syndrome protein and DNA polymerase delta
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair
A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01
DNA Polymerase delta tetramer.complex_inactive
New players in the BRCA1-mediated DNA damage responsive pathway
Chromatin dynamics coupled to DNA repair
BRCA-1-associated genome surveillance complex
Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage
The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction
Replication factor C clamp loader subunit arrangement within the circular pentamer and its attachment points to proliferating cell nuclear antigen
Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts
HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes
Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage
The ATM-mediated DNA-damage response: taking shape
PhysicalInteraction [Complex Condensin II {} -- MCPH1 ]
Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans
Chk1 and Chk2 kinases in checkpoint control and cancer
PTIP Regulates 53BP1 and SMC1 at the DNA Damage Sites
Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition
PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene
Essential role for nuclear PTEN in maintaining chromosomal integrity
MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis
Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX
Dancing on damaged chromatin: functions of ATM and the RAD50/MRE11/NBS1 complex in cellular responses to DNA damage
Human claspin is required for replication checkpoint control
gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes