E2Fs link the control of G1/S and G2/M transcription
p21(Waf1/Cip1) inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice
Efficient activation of p53 pathway in A549 cells exposed to L2, a novel compound targeting p53-MDM2 interaction
Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase
PhysicalInteraction [ATM -- Complex SWI/SNF {} ]
Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway
Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus
SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization
Anaphase promoting complex / FZR1(CDH1) activator
Cell cycle-dependent phosphorylation of the large subunit of replication factor C (RF-C) leads to its dissociation from the RF-C complex
Gadd45a contributes to p53 stabilization in response to DNA damage
Mechanism of ATP-driven PCNA clamp loading by S. cerevisiae RFC
A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression
Human SNF5/INI1, a component of the human SWI/SNF chromatin remodeling complex, promotes nucleotide excision repair by influencing ATM recruitment and downstream H2AX phosphorylation
Chk1 in the DNA damage response: conserved roles from yeasts to mammals
Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response
Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition
Overexpression of ICBP90, a novel CCAAT-binding protein, overcomes cell contact inhibition by forcing topoisomerase II alpha expression
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
Enhanced phosphorylation of p53 by ATM in response to DNA damage
Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism
Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F
GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress
Pro-proliferative FoxM1 is a target of p53-mediated repression
CyclinB-Cdc2 (CDK1)- M-phase-promoting factor (MPF)
Divorcing ARF and p53: an unsettled case
Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double strand breaks
Physical and functional interaction between the Bloom's syndrome gene product and the largest subunit of chromatin assembly factor 1
Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression
ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain
Computer-assisted identification of cell cycle-related genes: new targets for E2F transcription factors.
Differential regulation of expression of the mammalian DNA repair genes by growth stimulation
The anaphase-promoting complex: a key factor in the regulation of cell cycle
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
Highly potent p21(WAF1)-derived peptide inhibitors of CDK-mediated pRb phosphorylation: delineation and structural insight into their interactions with cyclin A
Regulation of DNA repair throughout the cell cycle
Gadd45a, a p53- and BRCA1-regulated stress protein, in cellular response to DNA damage
Interaction between YY1 and the retinoblastoma protein. Regulation of cell cycle progression in differentiated cells.
Global mapping of c-Myc binding sites and target gene networks in human B cells
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage
Expression of MCM10 and TopBP1 is regulated by cell proliferation and UV irradiation via the E2F transcription factor
Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells
The decision to enter mitosis: feedback and redundancy in the mitotic entry network
Role of the mammalian SWI/SNF chromatin remodeling complex in the cellular response to UV damage
Hierarchical order of phosphorylation events commits Cdc25A to betaTrCP-dependent degradation
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
p21/CDKN1A mediates negative regulation of transcription by p53
A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein
The C terminus of p53 binds the N-terminal domain of MDM2
Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase
ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression
Regulation of early events in chromosome replication
Cell death by mitotic catastrophe: a molecular definition
Replication factor C clamp loader subunit arrangement within the circular pentamer and its attachment points to proliferating cell nuclear antigen
Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F
Rapid activation of ATR by ionizing radiation requires ATM and Mre11
The Bcl2 family: regulators of the cellular life-or-death switch
ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage
E2F-dependent induction of p14ARF during cell cycle re-entry in human T cells
Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts
A CAF-1-PCNA-mediated chromatin assembly pathway triggered by sensing DNA damage
ATM associates with and phosphorylates p53: mapping the region of interaction
Dose-dependent mutual regulation between Wip1 and p53 following UVC irradiation
PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition
Base damage and single-strand break repair: mechanisms and functional significance of short- and long-patch repair subpathways
Rb regulates fate choice and lineage commitment in vivo
Towards a proteome-scale map of the human protein-protein interaction network
Activated APC/C (complexed with the cdc20 activator)
Connecting proliferation and apoptosis in development and disease
Chk1 and Chk2 kinases in checkpoint control and cancer
Arrest of G(1)-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcription
Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit
Mcm10 regulates the stability and chromatin association of DNA polymerase-alpha
Human claspin is required for replication checkpoint control
Function and regulation of the transcription factors of the Myc/Max/Mad network