Translation
type: MolecularInteraction
participant: RB1_inactive
participant: RB1_RNA

Translation
type: MolecularInteraction
participant: PCNA_inactive
participant: PCNA_RNA

RBL1
type: Protein
entity reference: RBL1

.MYBL2.PROMOTES.CCNB1.
type: TemplateReactionRegulation
data source: Spike
xref: 15510213
controller: MYBL2
controlled: Transcription.Regulation.P.MYBL2.CCNB1
control type: ACTIVATION

15510213
type: PublicationXref
id: 15510213
title: E2Fs link the control of G1/S and G2/M transcription
db: PubMed

BTG2_DNA
type: DnaRegion
entity reference: BTG2

http://www.ncbi.nlm.nih.gov/#5111
type: UnificationXref
id: 5111
db: Entrez Gene

CAF-1.complex_inactive
type: Protein

CDKN1A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1026

9858545
type: PublicationXref
id: 9858545
title: p21(Waf1/Cip1) inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption
db: PubMed

10859164
type: PublicationXref
id: 10859164
title: Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
db: PubMed

10859163
type: PublicationXref
id: 10859163
title: Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice
db: PubMed

DHFR_DNA
type: DnaRegion
entity reference: DHFR

MYC
type: Protein
entity reference: MYC

.Family.E2F1.3....PROMOTES.MCM10.
type: TemplateReactionRegulation
data source: Spike
xref: 15195143
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.MCM10
control type: ACTIVATION

19579266
type: PublicationXref
id: 19579266
title: Efficient activation of p53 pathway in A549 cells exposed to L2, a novel compound targeting p53-MDM2 interaction
db: PubMed

http://www.ncbi.nlm.nih.gov/#891
type: UnificationXref
id: 891
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#894
type: UnificationXref
id: 894
db: Entrez Gene

.CDKN1A.INHIBITS.Complex.CycA.Cdk2..CDK2..
type: Catalysis
data source: Spike
controller: CDKN1A
controlled: Physical.Interaction.I.CDKN1A.CycA.Cdk2
xref: 12383116
control type: INHIBITION

http://www.ncbi.nlm.nih.gov/#896
type: UnificationXref
id: 896
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#898
type: UnificationXref
id: 898
db: Entrez Gene

RBL2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5934

DHFR
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1719

pre_RC.complex_inactive
type: Protein

RFC1_inactive
type: Protein
entity reference: RFC1

CHEK2_inactive
type: Protein
entity reference: CHEK2

http://www.ncbi.nlm.nih.gov/#51053
type: UnificationXref
id: 51053
db: Entrez Gene

PhysicalInteraction [GADD45A -- PCNA ]
type: MolecularInteraction
participant: PCNA
participant: GADD45A
xref: 16189514

RAD9A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5883

MCM6_RNA
type: RnaRegion
entity reference: MCM6

8348613
type: PublicationXref
id: 8348613
title: Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase
db: PubMed

http://www.ncbi.nlm.nih.gov/#9133
type: UnificationXref
id: 9133
db: Entrez Gene

CCND2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#894

DHFR
type: Protein
entity reference: DHFR

TK1_RNA
type: RnaRegion
entity reference: TK1

CDK4_RNA
type: RnaRegion
entity reference: CDK4

CHEK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1111

GADD45A_RNA
type: RnaRegion
entity reference: GADD45A

.CDKN1A.INHIBITS.Complex.CycE.Cdk2..CCNE1,.CDK2.(CDK2).
type: Catalysis
data source: Spike
controller: CDKN1A
controlled: Physical.Interaction.I.CDKN1A.CycE.Cdk2
xref: 9858545
control type: INHIBITION

http://www.ncbi.nlm.nih.gov/#7083
type: UnificationXref
id: 7083
db: Entrez Gene

CDKN2A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1029

CCND1
type: Protein
entity reference: CCND1

RB1_DNA
type: DnaRegion
entity reference: RB1

Replication Factor C
type: Complex
data source: Spike
display name: RFC.complex
component: RFC1

APC/C-FZR1.complex_inactive
type: Protein

ATR
type: Protein
entity reference: ATR

CDK1
type: Protein
entity reference: CDK1

TRIM28
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#10155

.Complex.SWI/SNF....PROMOTES.CDKN1A.
type: TemplateReactionRegulation
data source: Spike
xref: 18414052
controller: SWI/SNF
controlled: Transcription.Regulation.P.SWI/SNF.CDKN1A
control type: ACTIVATION

DHFR_RNA
type: RnaRegion
entity reference: DHFR

CCND1_inactive
type: Protein
entity reference: CCND1

RFC.complex_inactive
type: Protein

.ATR.PROMOTES.Complex.911.complex..RAD1,.RAD9A,.HUS1.(RAD1).
type: Catalysis
data source: Spike
controller: ATR
controlled: Phosphorylation.P.ATR.911.complex
xref: 16436514
control type: ACTIVATION

PhysicalInteraction [ATM -- Complex SWI/SNF {} ]
type: MolecularInteraction
participant: ATM
participant: SWI/SNF
xref: 19805520

.CDKN2A.INHIBITS.Complex.CycD.Cdk4..Family.CycD..CCND1,.CCND2,.CCND3.,.CDK4..
type: Catalysis
data source: Spike
controller: CDKN2A
controlled: Physical.Interaction.I.CDKN2A.CycD.Cdk4
xref: 15459661
control type: INHIBITION

MDM2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4193

CDC6_RNA
type: RnaRegion
entity reference: CDC6

8944033
type: PublicationXref
id: 8944033
title: Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway
db: PubMed

http://www.ncbi.nlm.nih.gov/#7157
type: UnificationXref
id: 7157
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#7153
type: UnificationXref
id: 7153
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#1869
type: UnificationXref
id: 1869
db: Entrez Gene

MCM6_DNA
type: DnaRegion
entity reference: MCM6

Translation
type: MolecularInteraction
participant: TOP2A
participant: TOP2A_RNA

MYBL2_RNA
type: RnaRegion
entity reference: MYBL2

.Family.E2F1.3....PROMOTES.MYC.
type: TemplateReactionRegulation
data source: Spike
xref: 11491305
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.MYC
control type: ACTIVATION

Translation
type: MolecularInteraction
participant: RAD51_RNA
participant: RAD51

GADD45A_DNA
type: DnaRegion
entity reference: GADD45A

E2F1-3.family_inactive
type: Protein

ATR
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#545

16436514
type: PublicationXref
id: 16436514
title: Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus
db: PubMed

POLA1
type: Protein
entity reference: POLA1

CDC6
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#990

.BLM.PROMOTES.Complex.CAF.1...(CHAF1A).
type: Catalysis
data source: Spike
controller: BLM
controlled: Physical.Interaction.P.BLM.CAF.1
xref: 15143166
control type: ACTIVATION

http://www.ncbi.nlm.nih.gov/#7832
type: UnificationXref
id: 7832
db: Entrez Gene

BTG2_RNA
type: RnaRegion
entity reference: BTG2

20424263
type: PublicationXref
id: 20424263
title: SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1
db: PubMed

9889196
type: PublicationXref
id: 9889196
title: Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization
db: PubMed

http://www.ncbi.nlm.nih.gov/#11200
type: UnificationXref
id: 11200
db: Entrez Gene

RFC1
type: Protein
entity reference: RFC1

MCM5_RNA
type: RnaRegion
entity reference: MCM5

RB Family.family
type: Protein
data source: Spike
member physical entity: RBL2
member physical entity: RBL1
member physical entity: RB1
xref: ELK:F.329908

Anaphase promoting complex / FZR1(CDH1) activator
type: Complex
data source: Spike
display name: APC/C-FZR1.complex

http://www.ncbi.nlm.nih.gov/#10155
type: UnificationXref
id: 10155
db: Entrez Gene

ATM
type: Protein
entity reference: ATM

MYC_DNA
type: DnaRegion
entity reference: MYC

CDKN2A
type: Protein
entity reference: CDKN2A

12947101
type: PublicationXref
id: 12947101
title: Cell cycle-dependent phosphorylation of the large subunit of replication factor C (RF-C) leads to its dissociation from the RF-C complex
db: PubMed

.Family.E2F1.3....PROMOTES.RAD51.
type: TemplateReactionRegulation
data source: Spike
xref: 15467751
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.RAD51
control type: ACTIVATION

14627995
type: PublicationXref
id: 14627995
title: Gadd45a contributes to p53 stabilization in response to DNA damage
db: PubMed

19285992
type: PublicationXref
id: 19285992
title: Mechanism of ATP-driven PCNA clamp loading by S. cerevisiae RFC
db: PubMed

PCNA
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5111

11340163
type: PublicationXref
id: 11340163
title: A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression
db: PubMed

.Family.E2F1.3....PROMOTES.RB1.
type: TemplateReactionRegulation
data source: Spike
xref: 11491305
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.RB1
control type: ACTIVATION

Translation
type: MolecularInteraction
participant: GADD45A
participant: GADD45A_RNA

19805520
type: PublicationXref
id: 19805520
title: Human SNF5/INI1, a component of the human SWI/SNF chromatin remodeling complex, promotes nucleotide excision repair by influencing ATM recruitment and downstream H2AX phosphorylation
db: PubMed

BTG2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7832

CCNE1_DNA
type: DnaRegion
entity reference: CCNE1

TP53_inactive
type: Protein
entity reference: TP53

15279789
type: PublicationXref
id: 15279789
title: Chk1 in the DNA damage response: conserved roles from yeasts to mammals
db: PubMed

.Complex.APC/C.CDC20....INHIBITS.GMNN.
type: Catalysis
data source: Spike
controller: Activated APC/C (complexed with the cdc20 activator)
controlled: Ubiquitination.I.APC/C.CDC20.GMNN
xref: 15380092
control type: INHIBITION

BTG2
type: Protein
entity reference: BTG2

RAD51
type: Protein
entity reference: RAD51

RB1
type: Protein
entity reference: RB1

.Family.E2F1.3....PROMOTES.TK1.
type: TemplateReactionRegulation
data source: Spike
xref: 11491305
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.TK1
control type: ACTIVATION

.CDKN1A.INHIBITS.PCNA.
type: Catalysis
data source: Spike
controller: CDKN1A
controlled: Physical.Interaction.I.CDKN1A.PCNA
xref: 17129767
control type: INHIBITION

.TP53.PROMOTES.BTG2.
type: TemplateReactionRegulation
data source: Spike
xref: 8944033
xref: 10669755
controller: TP53
controlled: Transcription.Regulation.P.TP53.BTG2
control type: ACTIVATION

Homo sapiens
type: BioSource
xref: 9606

.Family.E2F1.3....PROMOTES.MYBL2.
type: TemplateReactionRegulation
data source: Spike
xref: 15510213
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.MYBL2
control type: ACTIVATION

16360315
type: PublicationXref
id: 16360315
title: Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response
db: PubMed

MCM5
type: Protein
entity reference: MCM5

CCNB1_DNA
type: DnaRegion
entity reference: CCNB1

20360007
type: PublicationXref
id: 20360007
title: Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition
db: PubMed

http://www.ncbi.nlm.nih.gov/#5810
type: UnificationXref
id: 5810
db: Entrez Gene

12530060
type: PublicationXref
id: 12530060
title: Overexpression of ICBP90, a novel CCAAT-binding protein, overcomes cell contact inhibition by forcing topoisomerase II alpha expression
db: PubMed

RAD1
type: Protein
entity reference: RAD1

CDC6
type: Protein
entity reference: CDC6

UHRF1_RNA
type: RnaRegion
entity reference: UHRF1

.Family.E2F1.3....PROMOTES.CDK1.
type: TemplateReactionRegulation
data source: Spike
xref: 11491305
xref: 15510213
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.CDK1
control type: ACTIVATION

MCM10_DNA
type: DnaRegion
entity reference: MCM10

CDK1_inactive
type: Protein
entity reference: CDK1

MCM6
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4175

CCND3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#896

.Family.E2F1.3....PROMOTES.CDKN2A.
type: TemplateReactionRegulation
data source: Spike
xref: 11491305
xref: 17912037
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.CDKN2A
control type: ACTIVATION

9733515
type: PublicationXref
id: 9733515
title: Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
db: PubMed

CDK2
type: Protein
entity reference: CDK2

ATM
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#472

9733514
type: PublicationXref
id: 9733514
title: Enhanced phosphorylation of p53 by ATM in response to DNA damage
db: PubMed

Translation
type: MolecularInteraction
participant: DHFR_RNA
participant: DHFR

http://www.ncbi.nlm.nih.gov/#4609
type: UnificationXref
id: 4609
db: Entrez Gene

CycE-Cdk2.complex_inactive
type: Protein

.MYC.PROMOTES.CDC25A.
type: TemplateReactionRegulation
data source: Spike
xref: 11602341
controller: MYC
controlled: Transcription.Regulation.P.MYC.CDC25A
control type: ACTIVATION

MCM5_DNA
type: DnaRegion
entity reference: MCM5

CycD.family
type: Protein
data source: Spike
member physical entity: CCND3
member physical entity: CCND1
member physical entity: CCND2
xref: TAU:F.000006

http://www.ncbi.nlm.nih.gov/#4605
type: UnificationXref
id: 4605
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#641
type: UnificationXref
id: 641
db: Entrez Gene

Translation
type: MolecularInteraction
participant: CDKN2A
participant: CDKN2A_RNA

.MDM2.INHIBITS.TP53.
type: Catalysis
data source: Spike
controller: MDM2
controlled: Physical.Interaction.I.MDM2.TP53
xref: 11331603
xref: 20639885
xref: 19579266
control type: INHIBITION

Translation
type: MolecularInteraction
participant: CCNB1_RNA
participant: CCNB1

http://www.ncbi.nlm.nih.gov/#5981
type: UnificationXref
id: 5981
db: Entrez Gene

CCNB2
type: Protein
entity reference: CCNB2

.PCNA.PROMOTES.RFC1.
type: Catalysis
data source: Spike
controller: PCNA
controlled: Physical.Interaction.P.PCNA.RFC1
xref: 19285992
control type: ACTIVATION

CHEK1
type: Protein
entity reference: CHEK1

CCND1_DNA
type: DnaRegion
entity reference: CCND1

15272308
type: PublicationXref
id: 15272308
title: Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism
db: PubMed

9774682
type: PublicationXref
id: 9774682
title: Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F
db: PubMed

CycD-Cdk4.complex_inactive
type: Protein

CHEK2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#11200

Translation
type: MolecularInteraction
participant: UHRF1_RNA
participant: UHRF1

12124778
type: PublicationXref
id: 12124778
title: GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress
db: PubMed

CDKN1A_RNA
type: RnaRegion
entity reference: CDKN1A

http://www.ncbi.nlm.nih.gov/#545
type: UnificationXref
id: 545
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#7528
type: UnificationXref
id: 7528
db: Entrez Gene

.Complex.CycA.Cdk2..CDK2..INHIBITS.Complex.APC/C.FZR1...(CDC23).
type: Catalysis
data source: Spike
controller: CycA-Cdk2
controlled: Phosphorylation.I.CycA.Cdk2.APC/C.FZR1
xref: 11340163
control type: INHIBITION

MYBL2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4605

19749794
type: PublicationXref
id: 19749794
title: Pro-proliferative FoxM1 is a target of p53-mediated repression
db: PubMed

TP53
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7157

http://www.ncbi.nlm.nih.gov/#5422
type: UnificationXref
id: 5422
db: Entrez Gene

.CHEK2.INHIBITS.CDC25A.
type: Catalysis
data source: Spike
controller: CHEK2
controlled: Phosphorylation.I.CHEK2.CDC25A
xref: 18285803
control type: INHIBITION

RAD51_RNA
type: RnaRegion
entity reference: RAD51

CyclinB-Cdc2 (CDK1)- M-phase-promoting factor (MPF)
type: Complex
data source: Spike
display name: CycB-Cdc2.complex
component: CDK1
component: CycB.family

CDK4
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1019

CDK4
type: Protein
entity reference: CDK4

http://www.ncbi.nlm.nih.gov/#4175
type: UnificationXref
id: 4175
db: Entrez Gene

RB1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5925

http://www.ncbi.nlm.nih.gov/#4174
type: UnificationXref
id: 4174
db: Entrez Gene

.BTG2.INHIBITS.CCND1.
type: Catalysis
data source: Spike
controller: BTG2
controlled: Other.I.BTG2.CCND1
xref: 10669755
control type: INHIBITION

http://www.ncbi.nlm.nih.gov/#595
type: UnificationXref
id: 595
db: Entrez Gene

TOP2A_DNA
type: DnaRegion
entity reference: TOP2A

http://www.ncbi.nlm.nih.gov/#990
type: UnificationXref
id: 990
db: Entrez Gene

Spike
type: Provenance

http://www.ncbi.nlm.nih.gov/#29128
type: UnificationXref
id: 29128
db: Entrez Gene

.Family.E2F1.3....PROMOTES.PCNA.
type: TemplateReactionRegulation
data source: Spike
xref: 11491305
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.PCNA
control type: ACTIVATION

http://www.ncbi.nlm.nih.gov/#993
type: UnificationXref
id: 993
db: Entrez Gene

Translation
type: MolecularInteraction
participant: CDK4_RNA
participant: CDK4

.RB1.INHIBITS.Family.E2F1.3....
type: Catalysis
data source: Spike
controller: RB1
controlled: Physical.Interaction.I.RB1.E2F1.3
xref: 20686481
control type: INHIBITION

.Family.E2F1.3....PROMOTES.CDC25A.
type: TemplateReactionRegulation
data source: Spike
xref: 11491305
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.CDC25A
control type: ACTIVATION

CDK1_DNA
type: DnaRegion
entity reference: CDK1

Translation
type: MolecularInteraction
participant: MCM6_RNA
participant: MCM6

RB1_inactive
type: Protein
entity reference: RB1

MCM6
type: Protein
entity reference: MCM6

http://www.ncbi.nlm.nih.gov/#5883
type: UnificationXref
id: 5883
db: Entrez Gene

MCM10
type: Protein
entity reference: MCM10

TK1
type: Protein
entity reference: TK1

YY1
type: Protein
entity reference: YY1

16915296
type: PublicationXref
id: 16915296
title: Divorcing ARF and p53: an unsettled case
db: PubMed

Cyclin E - CDK2
type: Complex
data source: Spike
display name: CycE-Cdk2.complex
component: CDK2
component: CCNE1

http://www.ncbi.nlm.nih.gov/#983
type: UnificationXref
id: 983
db: Entrez Gene

CDC25A_inactive
type: Protein
entity reference: CDC25A

http://www.ncbi.nlm.nih.gov/#5888
type: UnificationXref
id: 5888
db: Entrez Gene

Translation
type: MolecularInteraction
participant: MYBL2
participant: MYBL2_RNA

TOP2A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7153

911-complex.complex_inactive
type: Protein

http://www.ncbi.nlm.nih.gov/#4193
type: UnificationXref
id: 4193
db: Entrez Gene

MDM2
type: Protein
entity reference: MDM2

.TP53.PROMOTES.CDKN1A.
type: TemplateReactionRegulation
data source: Spike
xref: 12748190
xref: 21163364
xref: 19749794
controller: TP53
controlled: Transcription.Regulation.P.TP53.CDKN1A
control type: ACTIVATION

17272272
type: PublicationXref
id: 17272272
title: Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double strand breaks
db: PubMed

.ATM.PROMOTES.TP53.
type: Catalysis
data source: Spike
controller: ATM
controlled: Phosphorylation.P.ATM.TP53
xref: 9733515
xref: 9733514
xref: 9843217
control type: ACTIVATION

15143166
type: PublicationXref
id: 15143166
title: Physical and functional interaction between the Bloom's syndrome gene product and the largest subunit of chromatin assembly factor 1
db: PubMed

911
type: Complex
data source: Spike
display name: 911-complex.complex
component: HUS1
component: RAD9A
component: RAD1

http://www.ncbi.nlm.nih.gov/#472
type: UnificationXref
id: 472
db: Entrez Gene

17942393
type: PublicationXref
id: 17942393
title: Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression
db: PubMed

chromatin assembly factor 1
type: Complex
data source: Spike
display name: CAF-1.complex

CCND2
type: Protein
entity reference: CCND2

http://www.ncbi.nlm.nih.gov/#4292
type: UnificationXref
id: 4292
db: Entrez Gene

pre_Replication Complex
type: Complex
data source: Spike
display name: pre_RC.complex
component: MCM10
component: CDC6
component: MCM5
component: MCM6

http://www.ncbi.nlm.nih.gov/#5925
type: UnificationXref
id: 5925
db: Entrez Gene

.MYC.PROMOTES.CDK4.
type: TemplateReactionRegulation
data source: Spike
xref: 17093053
xref: 11602341
controller: MYC
controlled: Transcription.Regulation.P.MYC.CDK4
control type: ACTIVATION

http://www.ncbi.nlm.nih.gov/#1647
type: UnificationXref
id: 1647
db: Entrez Gene

.TP53.PROMOTES.GADD45A.
type: TemplateReactionRegulation
data source: Spike
xref: 16990795
xref: 14627995
xref: 15603758
controller: TP53
controlled: Transcription.Regulation.P.TP53.GADD45A
control type: ACTIVATION

CycB.family
type: Protein
data source: Spike
member physical entity: CCNB1
member physical entity: CCNB2
xref: CEN:F.329953

.Complex.CycB.Cdc2..CDK1,.Family.CycB..CCNB1,.CCNB2...INHIBITS.Complex.RFC..RFC1.(RFC1).
type: Catalysis
data source: Spike
controller: CyclinB-Cdc2 (CDK1)- M-phase-promoting factor (MPF)
controlled: Phosphorylation.I.CycB.Cdc2.RFC
xref: 12947101
control type: INHIBITION

CDC6_DNA
type: DnaRegion
entity reference: CDC6

15361834
type: PublicationXref
id: 15361834
title: ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain
db: PubMed

.ATM.PROMOTES.CHEK2.
type: Catalysis
data source: Spike
controller: ATM
controlled: Phosphorylation.P.ATM.CHEK2
xref: 12773400
xref: 9889122
control type: ACTIVATION

http://www.ncbi.nlm.nih.gov/#5933
type: UnificationXref
id: 5933
db: Entrez Gene

MYC
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4609

http://www.ncbi.nlm.nih.gov/#5934
type: UnificationXref
id: 5934
db: Entrez Gene

CycA-Cdk2.complex_inactive
type: Protein

11491305
type: PublicationXref
id: 11491305
title: Computer-assisted identification of cell cycle-related genes: new targets for E2F transcription factors.
db: PubMed

PCNA_RNA
type: RnaRegion
entity reference: PCNA

15467751
type: PublicationXref
id: 15467751
title: Differential regulation of expression of the mammalian DNA repair genes by growth stimulation
db: PubMed

15678131
type: PublicationXref
id: 15678131
title: The anaphase-promoting complex: a key factor in the regulation of cell cycle
db: PubMed

9889122
type: PublicationXref
id: 9889122
title: A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
db: PubMed

CDC6_inactive
type: Protein
entity reference: CDC6

.UHRF1.PROMOTES.TOP2A.
type: TemplateReactionRegulation
data source: Spike
xref: 10646863
xref: 12530060
controller: UHRF1
controlled: Transcription.Regulation.P.UHRF1.TOP2A
control type: ACTIVATION

PCNA_inactive
type: Protein
entity reference: PCNA

CCNE1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#898

12383116
type: PublicationXref
id: 12383116
title: Highly potent p21(WAF1)-derived peptide inhibitors of CDK-mediated pRb phosphorylation: delineation and structural insight into their interactions with cyclin A
db: PubMed

BLM
type: Protein
entity reference: BLM

YY1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7528

CDKN1A_DNA
type: DnaRegion
entity reference: CDKN1A

CCNB1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#891

18285803
type: PublicationXref
id: 18285803
title: Regulation of DNA repair throughout the cell cycle
db: PubMed

RAD51_DNA
type: DnaRegion
entity reference: RAD51

.Family.E2F1.3....PROMOTES.UHRF1.
type: TemplateReactionRegulation
data source: Spike
xref: 15361834
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.UHRF1
control type: ACTIVATION

TP53
type: Protein
entity reference: TP53

MLH1
type: Protein
entity reference: MLH1

15603758
type: PublicationXref
id: 15603758
title: Gadd45a, a p53- and BRCA1-regulated stress protein, in cellular response to DNA damage
db: PubMed

.ATR.PROMOTES.CHEK1.
type: Catalysis
data source: Spike
controller: ATR
controlled: Phosphorylation.P.ATR.CHEK1
xref: 16431910
xref: 15279789
xref: 12766152
xref: 12781359
xref: 15190204
xref: 15272308
xref: 10859164
xref: 10859163
xref: 16360315
xref: 11090622
xref: 11390642
control type: ACTIVATION

RFC1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5981

CCNB1
type: Protein
entity reference: CCNB1

11118439
type: PublicationXref
id: 11118439
title: Interaction between YY1 and the retinoblastoma protein. Regulation of cell cycle progression in differentiated cells.
db: PubMed

HUS1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3364

Translation
type: MolecularInteraction
participant: MCM10
participant: MCM10_RNA

.TRIM28.INHIBITS.CDKN1A.
type: TemplateReactionRegulation
data source: Spike
xref: 17942393
controller: TRIM28
controlled: Transcription.Regulation.I.TRIM28.CDKN1A
control type: INHIBITION

17093053
type: PublicationXref
id: 17093053
title: Global mapping of c-Myc binding sites and target gene networks in human B cells
db: PubMed

Translation
type: MolecularInteraction
participant: BTG2
participant: BTG2_RNA

CCNE1
type: Protein
entity reference: CCNE1

E2F1_DNA
type: DnaRegion
entity reference: E2F1

RBL1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5933

.Family.E2F1.3....PROMOTES.CCNB1.
type: TemplateReactionRegulation
data source: Spike
xref: 15510213
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.CCNB1
control type: ACTIVATION

CycB-Cdc2.complex_inactive
type: Protein

11331603
type: PublicationXref
id: 11331603
title: ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage
db: PubMed

15195143
type: PublicationXref
id: 15195143
title: Expression of MCM10 and TopBP1 is regulated by cell proliferation and UV irradiation via the E2F transcription factor
db: PubMed

MYC_RNA
type: RnaRegion
entity reference: MYC

CCNE1_RNA
type: RnaRegion
entity reference: CCNE1

.CHEK1.INHIBITS.CDC25A.
type: Catalysis
data source: Spike
controller: CHEK1
controlled: Phosphorylation.I.CHEK1.CDC25A
xref: 18480045
xref: 14752276
control type: INHIBITION

Translation
type: MolecularInteraction
participant: CDC6_RNA
participant: CDC6_inactive

9520412
type: PublicationXref
id: 9520412
title: Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells
db: PubMed

.HUS1.PROMOTES.PCNA.
type: Catalysis
data source: Spike
controller: HUS1
controlled: Physical.Interaction.P.HUS1.PCNA
xref: 11077446
control type: ACTIVATION

Translation
type: MolecularInteraction
participant: E2F1_RNA
participant: E2F1

MLH1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4292

Translation
type: MolecularInteraction
participant: CDC25A_inactive
participant: CDC25A_RNA

E2F1_RNA
type: RnaRegion
entity reference: E2F1

HUS1
type: Protein
entity reference: HUS1

MCM10_RNA
type: RnaRegion
entity reference: MCM10

.CDC25A.PROMOTES.CDK2.
type: Catalysis
data source: Spike
controller: CDC25A
controlled: Dephosphorylation.P.CDC25A.CDK2
xref: 11602341
control type: ACTIVATION

19364923
type: PublicationXref
id: 19364923
title: The decision to enter mitosis: feedback and redundancy in the mitotic entry network
db: PubMed

18414052
type: PublicationXref
id: 18414052
title: Role of the mammalian SWI/SNF chromatin remodeling complex in the cellular response to UV damage
db: PubMed

14752276
type: PublicationXref
id: 14752276
title: Hierarchical order of phosphorylation events commits Cdc25A to betaTrCP-dependent degradation
db: PubMed

11390642
type: PublicationXref
id: 11390642
title: ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
db: PubMed

Translation
type: MolecularInteraction
participant: CCND1_RNA
participant: CCND1_inactive

12748190
type: PublicationXref
id: 12748190
title: p21/CDKN1A mediates negative regulation of transcription by p53
db: PubMed

GMNN
type: Protein
entity reference: GMNN

MLH1_DNA
type: DnaRegion
entity reference: MLH1

MDM2_inactive
type: Protein
entity reference: MDM2

.Family.E2F1.3....PROMOTES.MLH1.
type: TemplateReactionRegulation
data source: Spike
xref: 15467751
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.MLH1
control type: ACTIVATION

Translation
type: MolecularInteraction
participant: TK1
participant: TK1_RNA

12773400
type: PublicationXref
id: 12773400
title: A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein
db: PubMed

Translation
type: MolecularInteraction
participant: CDKN1A
participant: CDKN1A_RNA

CDC25A_RNA
type: RnaRegion
entity reference: CDC25A

CDK1_RNA
type: RnaRegion
entity reference: CDK1

20639885
type: PublicationXref
id: 20639885
title: The C terminus of p53 binds the N-terminal domain of MDM2
db: PubMed

.GADD45A.INHIBITS.Complex.CycB.Cdc2..CDK1,.Family.CycB..CCNB1,.CCNB2..(CDK1).
type: Catalysis
data source: Spike
controller: GADD45A
controlled: Physical.Interaction.I.GADD45A.CycB.Cdc2
xref: 12124778
control type: INHIBITION

18480045
type: PublicationXref
id: 18480045
title: Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase
db: PubMed

POLA1_inactive
type: Protein
entity reference: POLA1

.Complex.CycA.Cdk2..CDK2..INHIBITS.CDC6.
type: Catalysis
data source: Spike
controller: CycA-Cdk2
controlled: Phosphorylation.I.CycA.Cdk2.CDC6
xref: 9889196
control type: INHIBITION

RBL2
type: Protein
entity reference: RBL2

MYBL2_DNA
type: DnaRegion
entity reference: MYBL2

.Family.E2F1.3....PROMOTES.DHFR.
type: TemplateReactionRegulation
data source: Spike
xref: 11491305
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.DHFR
control type: ACTIVATION

TAU:F.000001
type: UnificationXref
id: TAU:F-000001
db: Spike DB

.PCNA.UNKNOWN.Complex.CAF.1...(CHAF1A).
type: Catalysis
data source: Spike
controller: PCNA
controlled: Physical.Interaction.U.PCNA.CAF.1
xref: 10648606
control type: ACTIVATION_UNKMECH

POLA1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5422

TAU:F.000006
type: UnificationXref
id: TAU:F-000006
db: Spike DB

10646863
type: PublicationXref
id: 10646863
title: ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression
db: PubMed

TRIM28_inactive
type: Protein
entity reference: TRIM28

.CDKN2A.INHIBITS.MDM2.
type: Catalysis
data source: Spike
controller: CDKN2A
controlled: Physical.Interaction.I.CDKN2A.MDM2
xref: 12209154
xref: 16915296
control type: INHIBITION

15380092
type: PublicationXref
id: 15380092
title: Regulation of early events in chromosome replication
db: PubMed

.CDKN1A.INHIBITS.Complex.CycB.Cdc2..CDK1,.Family.CycB..CCNB1,.CCNB2..(CDK1).
type: Catalysis
data source: Spike
controller: CDKN1A
controlled: Physical.Interaction.I.CDKN1A.CycB.Cdc2
xref: 15077146
control type: INHIBITION

.Family.E2F1.3....PROMOTES.CDC6.
type: TemplateReactionRegulation
data source: Spike
xref: 9774682
xref: 9778043
xref: 9520412
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.CDC6
control type: ACTIVATION

GADD45A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1647

.CDC25A.PROMOTES.CDK1.
type: Catalysis
data source: Spike
controller: CDC25A
controlled: Dephosphorylation.P.CDC25A.CDK1
xref: 20360007
control type: ACTIVATION

CDKN1A
type: Protein
entity reference: CDKN1A

.ATM.INHIBITS.TRIM28.
type: Catalysis
data source: Spike
controller: ATM
controlled: Phosphorylation.I.ATM.TRIM28
xref: 20424263
xref: 17942393
control type: INHIBITION

15077146
type: PublicationXref
id: 15077146
title: Cell death by mitotic catastrophe: a molecular definition
db: PubMed

Translation
type: MolecularInteraction
participant: CDK1_inactive
participant: CDK1_RNA

CCND1_RNA
type: RnaRegion
entity reference: CCND1

CDC25A_DNA
type: DnaRegion
entity reference: CDC25A

14530260
type: PublicationXref
id: 14530260
title: Replication factor C clamp loader subunit arrangement within the circular pentamer and its attachment points to proliferating cell nuclear antigen
db: PubMed

CDC25A
type: Protein
entity reference: CDC25A

9778043
type: PublicationXref
id: 9778043
title: Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F
db: PubMed

BLM
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#641

16431910
type: PublicationXref
id: 16431910
title: Rapid activation of ATR by ionizing radiation requires ATM and Mre11
db: PubMed

12209154
type: PublicationXref
id: 12209154
title: The Bcl2 family: regulators of the cellular life-or-death switch
db: PubMed

E2F1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1869

CCNB1_RNA
type: RnaRegion
entity reference: CCNB1

15190204
type: PublicationXref
id: 15190204
title: ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage
db: PubMed

UHRF1_DNA
type: DnaRegion
entity reference: UHRF1

minichromosome maintenance complex
type: Complex
data source: Spike
display name: MCM.complex
component: MCM10
component: MCM5
component: MCM6

17912037
type: PublicationXref
id: 17912037
title: E2F-dependent induction of p14ARF during cell cycle re-entry in human T cells
db: PubMed

http://www.ncbi.nlm.nih.gov/#1111
type: UnificationXref
id: 1111
db: Entrez Gene

CHEK1_inactive
type: Protein
entity reference: CHEK1

11090622
type: PublicationXref
id: 11090622
title: Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts
db: PubMed

10648606
type: PublicationXref
id: 10648606
title: A CAF-1-PCNA-mediated chromatin assembly pathway triggered by sensing DNA damage
db: PubMed

9606
type: UnificationXref
id: 9606
db: taxonomy

TRIM28
type: Protein
entity reference: TRIM28

.Family.E2F1.3....PROMOTES.MCM5.
type: TemplateReactionRegulation
data source: Spike
xref: 8348613
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.MCM5
control type: ACTIVATION

.Family.E2F1.3....PROMOTES.E2F1.
type: TemplateReactionRegulation
data source: Spike
xref: 11491305
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.E2F1
control type: ACTIVATION

http://www.ncbi.nlm.nih.gov/#1017
type: UnificationXref
id: 1017
db: Entrez Gene

GADD45A
type: Protein
entity reference: GADD45A

Translation
type: MolecularInteraction
participant: MCM5
participant: MCM5_RNA

.MYBL2.PROMOTES.CDK1.
type: TemplateReactionRegulation
data source: Spike
xref: 15510213
controller: MYBL2
controlled: Transcription.Regulation.P.MYBL2.CDK1
control type: ACTIVATION

CEN:F.329953
type: UnificationXref
id: CEN:F-329953
db: Spike DB

http://www.ncbi.nlm.nih.gov/#1019
type: UnificationXref
id: 1019
db: Entrez Gene

CDK4_DNA
type: DnaRegion
entity reference: CDK4

http://www.ncbi.nlm.nih.gov/#3364
type: UnificationXref
id: 3364
db: Entrez Gene

UHRF1
type: Protein
entity reference: UHRF1

CyclinD-CDK4
type: Complex
data source: Spike
display name: CycD-Cdk4.complex
component: CycD.family
component: CDK4

CCND1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#595

E2F1-3.family
type: Protein
data source: Spike
xref: TAU:F.000001

CCNB2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9133

http://www.ncbi.nlm.nih.gov/#1026
type: UnificationXref
id: 1026
db: Entrez Gene

Translation
type: MolecularInteraction
participant: MLH1_RNA
participant: MLH1

http://www.ncbi.nlm.nih.gov/#1029
type: UnificationXref
id: 1029
db: Entrez Gene

9843217
type: PublicationXref
id: 9843217
title: ATM associates with and phosphorylates p53: mapping the region of interaction
db: PubMed

21163364
type: PublicationXref
id: 21163364
title: Dose-dependent mutual regulation between Wip1 and p53 following UVC irradiation
db: PubMed

MYBL2
type: Protein
entity reference: MYBL2

CDKN2A_RNA
type: RnaRegion
entity reference: CDKN2A

http://www.ncbi.nlm.nih.gov/#1719
type: UnificationXref
id: 1719
db: Entrez Gene

CycA-Cdk2
type: Complex
data source: Spike
display name: CycA-Cdk2.complex
component: CDK2

CDK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#983

.Complex.RFC..RFC1..PROMOTES.PCNA.
type: Catalysis
data source: Spike
controller: Replication Factor C
controlled: Physical.Interaction.P.RFC.PCNA
xref: 14530260
control type: ACTIVATION

.MCM10.PROMOTES.POLA1.
type: Catalysis
data source: Spike
controller: MCM10
controlled: Physical.Interaction.P.MCM10.POLA1
xref: 15494305
control type: ACTIVATION

CDC25A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#993

.ATR.PROMOTES.TP53.
type: Catalysis
data source: Spike
controller: ATR
controlled: Phosphorylation.P.ATR.TP53
xref: 9733515
xref: 9733514
xref: 17272272
xref: 9843217
control type: ACTIVATION

.Family.E2F1.3....PROMOTES.CCND1.
type: TemplateReactionRegulation
data source: Spike
xref: 11491305
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.CCND1
control type: ACTIVATION

PCNA_DNA
type: DnaRegion
entity reference: PCNA

.Complex.APC/C.FZR1....INHIBITS.CDC6.
type: Catalysis
data source: Spike
controller: Anaphase promoting complex / FZR1(CDH1) activator
controlled: Ubiquitination.I.APC/C.FZR1.CDC6
xref: 15678131
control type: INHIBITION

.Family.E2F1.3....PROMOTES.CCNE1.
type: TemplateReactionRegulation
data source: Spike
xref: 11491305
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.CCNE1
control type: ACTIVATION

.TRIM28.INHIBITS.GADD45A.
type: TemplateReactionRegulation
data source: Spike
xref: 17942393
controller: TRIM28
controlled: Transcription.Regulation.I.TRIM28.GADD45A
control type: INHIBITION

11077446
type: PublicationXref
id: 11077446
title: PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition
db: PubMed

17129767
type: PublicationXref
id: 17129767
title: Base damage and single-strand break repair: mechanisms and functional significance of short- and long-patch repair subpathways
db: PubMed

.Complex.SWI/SNF....PROMOTES.GADD45A.
type: TemplateReactionRegulation
data source: Spike
xref: 18414052
controller: SWI/SNF
controlled: Transcription.Regulation.P.SWI/SNF.GADD45A
control type: ACTIVATION

TK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7083

20686481
type: PublicationXref
id: 20686481
title: Rb regulates fate choice and lineage commitment in vivo
db: PubMed

.CDC25A.PROMOTES.Complex.CycB.Cdc2..CDK1,.Family.CycB..CCNB1,.CCNB2..(CDK1).
type: Catalysis
data source: Spike
controller: CDC25A
controlled: Dephosphorylation.P.CDC25A.CycB.Cdc2
xref: 19364923
control type: ACTIVATION

SWI/SNF
type: Complex
data source: Spike
display name: SWI/SNF.complex

.Family.E2F1.3....PROMOTES.MCM6.
type: TemplateReactionRegulation
data source: Spike
xref: 8348613
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.MCM6
control type: ACTIVATION

RAD1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5810

Origion Recognition Complex
type: Complex
data source: Spike
display name: ORC.complex

GMNN
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#51053

16189514
type: PublicationXref
id: 16189514
title: Towards a proteome-scale map of the human protein-protein interaction network
db: PubMed

http://www.ncbi.nlm.nih.gov/#55388
type: UnificationXref
id: 55388
db: Entrez Gene

E2F1
type: Protein
entity reference: E2F1

CDK2_inactive
type: Protein
entity reference: CDK2

Translation
type: MolecularInteraction
participant: CCNE1_RNA
participant: CCNE1

PCNA
type: Protein
entity reference: PCNA

CCND3
type: Protein
entity reference: CCND3

Activated APC/C (complexed with the cdc20 activator)
type: Complex
data source: Spike
display name: APC/C-CDC20.complex

TOP2A
type: Protein
entity reference: TOP2A

15459661
type: PublicationXref
id: 15459661
title: Connecting proliferation and apoptosis in development and disease
db: PubMed

12781359
type: PublicationXref
id: 12781359
title: Chk1 and Chk2 kinases in checkpoint control and cancer
db: PubMed

Translation
type: MolecularInteraction
participant: MYC
participant: MYC_RNA

10669755
type: PublicationXref
id: 10669755
title: Arrest of G(1)-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcription
db: PubMed

UHRF1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#29128

RAD51
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5888

CDK2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1017

ELK:F.329908
type: UnificationXref
id: ELK:F-329908
db: Spike DB

RB1_RNA
type: RnaRegion
entity reference: RB1

CDKN2A_DNA
type: DnaRegion
entity reference: CDKN2A

TK1_DNA
type: DnaRegion
entity reference: TK1

MCM10
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#55388

TOP2A_RNA
type: RnaRegion
entity reference: TOP2A

16990795
type: PublicationXref
id: 16990795
title: Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit
db: PubMed

.YY1.UNKNOWN.RB1.
type: Catalysis
data source: Spike
controller: YY1
controlled: Physical.Interaction.U.YY1.RB1
xref: 11118439
control type: ACTIVATION_UNKMECH

MCM5
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4174

15494305
type: PublicationXref
id: 15494305
title: Mcm10 regulates the stability and chromatin association of DNA polymerase-alpha
db: PubMed

CHEK2
type: Protein
entity reference: CHEK2

RAD9A
type: Protein
entity reference: RAD9A

GMNN_inactive
type: Protein
entity reference: GMNN

.GMNN.INHIBITS.Complex.pre RC..CDC6,.MCM5,.MCM6,.MCM10.(CDC6).
type: Catalysis
data source: Spike
controller: GMNN
controlled: Physical.Interaction.I.GMNN.pre RC
xref: 15380092
control type: INHIBITION

12766152
type: PublicationXref
id: 12766152
title: Human claspin is required for replication checkpoint control
db: PubMed

MLH1_RNA
type: RnaRegion
entity reference: MLH1

11602341
type: PublicationXref
id: 11602341
title: Function and regulation of the transcription factors of the Myc/Max/Mad network
db: PubMed