http://www.ncbi.nlm.nih.gov/#151648
type: UnificationXref
db: Entrez Gene
id: 151648

16123593
type: PublicationXref
title: The N-terminal regulatory domain of cyclin A contains redundant ubiquitination targeting sequences and acceptor sites
db: PubMed
id: 16123593

.Complex.CycB.Cdc2..CDK1,.Family.CycB..CCNB1,.CCNB2...PROMOTES.CDC25B.
type: Catalysis
controlled: Phosphorylation.P.CycB.Cdc2.CDC25B
control type: ACTIVATION
data source: Spike
controller: CyclinB-Cdc2 (CDK1)- M-phase-promoting factor (MPF)
xref: 18237113

.MYBL2.PROMOTES.CCNB1.
type: TemplateReactionRegulation
xref: 15510213
controlled: Transcription.Regulation.P.MYBL2.CCNB1
control type: ACTIVATION
data source: Spike
controller: MYBL2

CFL1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1072

15510213
type: PublicationXref
title: E2Fs link the control of G1/S and G2/M transcription
db: PubMed
id: 15510213

15510216
type: PublicationXref
title: Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A
db: PubMed
id: 15510216

http://www.ncbi.nlm.nih.gov/#9700
type: UnificationXref
db: Entrez Gene
id: 9700

.ATM.PROMOTES.CHEK1.
type: Catalysis
controlled: Phosphorylation.P.ATM.CHEK1
control type: ACTIVATION
data source: Spike
controller: ATM
xref: 17525332
xref: 11252893

FOXM1_inactive
type: Protein
entity reference: FOXM1

.PLK1.PROMOTES.CCNB1.
type: Catalysis
controlled: Phosphorylation.P.PLK1.CCNB1
control type: ACTIVATION
data source: Spike
controller: PLK1
xref: 20126263
xref: 19364923

CDC25B_RNA
type: RnaRegion
entity reference: CDC25B

CLSPN
type: Protein
entity reference: CLSPN

AURKA
type: Protein
entity reference: AURKA

19276349
type: PublicationXref
title: Aurora A regulates prometaphase progression by inhibiting the ability of RASSF1A to suppress APC-Cdc20 activity
db: PubMed
id: 19276349

http://www.ncbi.nlm.nih.gov/#26271
type: UnificationXref
db: Entrez Gene
id: 26271

19228686
type: PublicationXref
title: Kinase signaling in the spindle checkpoint
db: PubMed
id: 19228686

AURKA
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6790

10859164
type: PublicationXref
title: Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
db: PubMed
id: 10859164

10859163
type: PublicationXref
title: Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice
db: PubMed
id: 10859163

.Family.PRKC..PKN2..INHIBITS.Family.Lamins...(LMNA).
type: Catalysis
controlled: Phosphorylation.I.PRKC.Lamins
control type: INHIBITION
data source: Spike
controller: PRKC.family
xref: 8034666

PLK1_inactive
type: Protein
entity reference: PLK1

http://www.ncbi.nlm.nih.gov/#699
type: UnificationXref
db: Entrez Gene
id: 699

SGOL1
type: Protein
entity reference: SGOL1

.FOXM1.PROMOTES.AURKB.
type: TemplateReactionRegulation
xref: 15689977
xref: 16314512
xref: 17173139
xref: 15817462
controlled: Transcription.Regulation.P.FOXM1.AURKB
control type: ACTIVATION
data source: Spike
controller: FOXM1

SGOL1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#151648

AURKB
type: Protein
entity reference: AURKB

CENPA_inactive
type: Protein
entity reference: CENPA

http://www.ncbi.nlm.nih.gov/#1073
type: UnificationXref
db: Entrez Gene
id: 1073

.ERBB2.INHIBITS.CDK1.
type: Catalysis
controlled: Phosphorylation.I.ERBB2.CDK1
control type: INHIBITION
data source: Spike
controller: ERBB2
xref: 12049736

.CDC42.UNKNOWN.CDC42EP4.
type: Catalysis
controlled: Physical.Interaction.U.CDC42.CDC42EP4
control type: ACTIVATION_UNKMECH
data source: Spike
controller: CDC42
xref: 10490598

http://www.ncbi.nlm.nih.gov/#1072
type: UnificationXref
db: Entrez Gene
id: 1072

http://www.ncbi.nlm.nih.gov/#891
type: UnificationXref
db: Entrez Gene
id: 891

.Complex.APC/C.CDC20....INHIBITS.CCNB1.
type: Catalysis
controlled: Ubiquitination.I.APC/C.CDC20.CCNB1
control type: INHIBITION
data source: Spike
controller: Activated APC/C (complexed with the cdc20 activator)
xref: 16123593
xref: 18319725
xref: 15733663
xref: 16647857

http://www.ncbi.nlm.nih.gov/#899
type: UnificationXref
db: Entrez Gene
id: 899

19680264
type: PublicationXref
title: Dissecting the role of ubiquitylation in the DNA damage response checkpoint in G2
db: PubMed
id: 19680264

16314512
type: PublicationXref
title: Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase
db: PubMed
id: 16314512

CHEK2_inactive
type: Protein
entity reference: CHEK2

http://www.ncbi.nlm.nih.gov/#1894
type: UnificationXref
db: Entrez Gene
id: 1894

CENPF
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1063

http://www.ncbi.nlm.nih.gov/#7272
type: UnificationXref
db: Entrez Gene
id: 7272

ESPL1_inactive
type: Protein
entity reference: ESPL1

http://www.ncbi.nlm.nih.gov/#1063
type: UnificationXref
db: Entrez Gene
id: 1063

CLSPN_inactive
type: Protein
entity reference: CLSPN

8348613
type: PublicationXref
title: Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase
db: PubMed
id: 8348613

http://www.ncbi.nlm.nih.gov/#1062
type: UnificationXref
db: Entrez Gene
id: 1062

14667408
type: PublicationXref
title: CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function
db: PubMed
id: 14667408

http://www.ncbi.nlm.nih.gov/#9133
type: UnificationXref
db: Entrez Gene
id: 9133

.RACGAP1.INHIBITS.CDC42.
type: Catalysis
controlled: Other.I.RACGAP1.CDC42
control type: INHIBITION
data source: Spike
controller: RACGAP1
xref: 15190208

CHEK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1111

KPNA2
type: Protein
entity reference: KPNA2

http://www.ncbi.nlm.nih.gov/#83461
type: UnificationXref
db: Entrez Gene
id: 83461

17525332
type: PublicationXref
title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
db: PubMed
id: 17525332

APC/C-CDC20.complex_inactive
type: Protein

AURKB
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9212

TPX2
type: Protein
entity reference: TPX2

Replication Factor C
type: Complex
display name: RFC.complex
data source: Spike

APC/C-FZR1.complex_inactive
type: Protein

http://www.ncbi.nlm.nih.gov/#10460
type: UnificationXref
db: Entrez Gene
id: 10460

.Complex.NF.Y....PROMOTES.CCNB1.
type: TemplateReactionRegulation
xref: 19364923
controlled: Transcription.Regulation.P.NF.Y.CCNB1
control type: ACTIVATION
data source: Spike
controller: NF-Y (trimer) transcription factor

ESPL1
type: Protein
entity reference: ESPL1

ATR
type: Protein
entity reference: ATR

CDK1
type: Protein
entity reference: CDK1

centromere-kinetochore
type: Complex
display name: centromere-kinetochore.complex
data source: Spike
component: TACC3
component: CENPE
component: CENPA
component: TACC2
component: CENPB
component: CENPF

RFC.complex_inactive
type: Protein

.Complex.PP2A....INHIBITS.ATM.
type: Catalysis
controlled: Dephosphorylation.I.PP2A.ATM
control type: INHIBITION
data source: Spike
controller: Protein phosphatase 2A
xref: 15510216

http://www.ncbi.nlm.nih.gov/#1058
type: UnificationXref
db: Entrez Gene
id: 1058

.PKN2.PROMOTES.CDC25B.
type: Catalysis
controlled: Phosphorylation.P.PKN2.CDC25B
control type: ACTIVATION
data source: Spike
controller: PKN2
xref: 17332740

http://www.ncbi.nlm.nih.gov/#1059
type: UnificationXref
db: Entrez Gene
id: 1059

CDC42EP4
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#23580

CFL2
type: Protein
entity reference: CFL2

11146641
type: PublicationXref
title: Together until separin do us part
db: PubMed
id: 11146641

.BUB1.INHIBITS.Complex.APC/C.CDC20...(CDC20).
type: Catalysis
controlled: Phosphorylation.I.BUB1.APC/C.CDC20
control type: INHIBITION
data source: Spike
controller: BUB1
xref: 15525512

.Complex.APC/C.CDC20....INHIBITS.PTTG1.
type: Catalysis
controlled: Ubiquitination.I.APC/C.CDC20.PTTG1
control type: INHIBITION
data source: Spike
controller: Activated APC/C (complexed with the cdc20 activator)
xref: 15678131
xref: 16647857

centromere-kinetochore.complex_inactive
type: Protein

Actin.family
type: Protein
data source: Spike
xref: ELK:F.000030

http://www.ncbi.nlm.nih.gov/#2064
type: UnificationXref
db: Entrez Gene
id: 2064

http://www.ncbi.nlm.nih.gov/#10579
type: UnificationXref
db: Entrez Gene
id: 10579

.Complex.CycB.Cdc2..CDK1,.Family.CycB..CCNB1,.CCNB2...PROMOTES.C13orf34.
type: Catalysis
controlled: Phosphorylation.P.CycB.Cdc2.C13orf34
control type: ACTIVATION
data source: Spike
controller: CyclinB-Cdc2 (CDK1)- M-phase-promoting factor (MPF)
xref: 19364923

ATR
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#545

CCNF
type: Protein
entity reference: CCNF

SGOL2
type: Protein
entity reference: SGOL2

CENPF
type: Protein
entity reference: CENPF

http://www.ncbi.nlm.nih.gov/#24137
type: UnificationXref
db: Entrez Gene
id: 24137

.DIAPH3.PROMOTES.Complex.centromere.kinetochore..CENPF,.CENPB,.CENPE,.CENPA,.TACC2,.TACC3.(CENPA).
type: Catalysis
controlled: Indirect.P.DIAPH3.centromere.kinetochore
control type: ACTIVATION
data source: Spike
controller: DIAPH3
xref: 15190208

Mitotic Spindle.complex_inactive
type: Protein

http://www.ncbi.nlm.nih.gov/#3838
type: UnificationXref
db: Entrez Gene
id: 3838

.AURKB.PROMOTES.CENPA.
type: Catalysis
controlled: Phosphorylation.P.AURKB.CENPA
control type: ACTIVATION
data source: Spike
controller: AURKB
xref: 11756469

.Complex.CycA.Cdk2....PROMOTES.MYBL2.
type: Catalysis
controlled: Phosphorylation.P.CycA.Cdk2.MYBL2
control type: ACTIVATION
data source: Spike
controller: CycA-Cdk2
xref: 10095772
xref: 9094315

.AURKA.PROMOTES.CDC25B.
type: Catalysis
controlled: Phosphorylation.P.AURKA.CDC25B
control type: ACTIVATION
data source: Spike
controller: AURKA
xref: 15128871

PRC1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9055

NUSAP1
type: Protein
entity reference: NUSAP1

http://www.ncbi.nlm.nih.gov/#11200
type: UnificationXref
db: Entrez Gene
id: 11200

CDC42
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#998

12738781
type: PublicationXref
title: Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate
db: PubMed
id: 12738781

Anaphase promoting complex / FZR1(CDH1) activator
type: Complex
display name: APC/C-FZR1.complex
data source: Spike

ATM
type: Protein
entity reference: ATM

PRC1_inactive
type: Protein
entity reference: PRC1

12947101
type: PublicationXref
title: Cell cycle-dependent phosphorylation of the large subunit of replication factor C (RF-C) leads to its dissociation from the RF-C complex
db: PubMed
id: 12947101

15630414
type: PublicationXref
title: Aurora-A - a guardian of poles
db: PubMed
id: 15630414

CKS2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1164

CENPE
type: Protein
entity reference: CENPE

DIAPH3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#81624

.Complex.CycB.Cdc2..CDK1,.Family.CycB..CCNB1,.CCNB2...PROMOTES.ECT2.
type: Catalysis
controlled: Phosphorylation.P.CycB.Cdc2.ECT2
control type: ACTIVATION
data source: Spike
controller: CyclinB-Cdc2 (CDK1)- M-phase-promoting factor (MPF)
xref: 17332740

.RHOA.PROMOTES.ROCK1.
type: Catalysis
controlled: Other.P.RHOA.ROCK1
control type: ACTIVATION
data source: Spike
controller: RHOA
xref: 15774750

Translation
type: MolecularInteraction
participant: AURKB_inactive
participant: AURKB_RNA

15279790
type: PublicationXref
title: Claspin, a regulator of Chk1 in DNA replication stress pathway
db: PubMed
id: 15279790

11340163
type: PublicationXref
title: A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression
db: PubMed
id: 11340163

LIMK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3984

17332740
type: PublicationXref
title: Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and exit from cytokinesis
db: PubMed
id: 17332740

17205132
type: PublicationXref
title: A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation
db: PubMed
id: 17205132

.PKMYT1.INHIBITS.Complex.CycB.Cdc2..CDK1,.Family.CycB..CCNB1,.CCNB2..(CDK1).
type: Catalysis
controlled: Phosphorylation.I.PKMYT1.CycB.Cdc2
control type: INHIBITION
data source: Spike
controller: PKMYT1
xref: 9001210

CIT
type: Protein
entity reference: CIT

.Complex.APC/C.FZR1....INHIBITS.PLK1.
type: Catalysis
controlled: Ubiquitination.I.APC/C.FZR1.PLK1
control type: INHIBITION
data source: Spike
controller: Anaphase promoting complex / FZR1(CDH1) activator
xref: 15678131
xref: 16647857

http://www.ncbi.nlm.nih.gov/#7465
type: UnificationXref
db: Entrez Gene
id: 7465

15279789
type: PublicationXref
title: Chk1 in the DNA damage response: conserved roles from yeasts to mammals
db: PubMed
id: 15279789

CLSPN
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#63967

12600307
type: PublicationXref
title: Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling
db: PubMed
id: 12600307

.Complex.CycB.Cdc2..CDK1,.Family.CycB..CCNB1,.CCNB2...INHIBITS.Complex.APC/C.FZR1...(CDC23).
type: Catalysis
controlled: Phosphorylation.I.CycB.Cdc2.APC/C.FZR1
control type: INHIBITION
data source: Spike
controller: CyclinB-Cdc2 (CDK1)- M-phase-promoting factor (MPF)
xref: 15678131

FBXO5
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#26271

.CDCA3.INHIBITS.WEE1.
type: Catalysis
controlled: Other.I.CDCA3.WEE1
control type: INHIBITION
data source: Spike
controller: CDCA3
xref: 15733861

Homo sapiens
type: BioSource
xref: 9606

CDC25C
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#995

AURKB_RNA
type: RnaRegion
entity reference: AURKB

AURKB_inactive
type: Protein
entity reference: AURKB

16360315
type: PublicationXref
title: Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response
db: PubMed
id: 16360315

LIMK1_inactive
type: Protein
entity reference: LIMK1

CENPA
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1058

http://www.ncbi.nlm.nih.gov/#81624
type: UnificationXref
db: Entrez Gene
id: 81624

CCNB1_DNA
type: DnaRegion
entity reference: CCNB1

11252893
type: PublicationXref
title: The many substrates and functions of ATM
db: PubMed
id: 11252893

ESPL1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9700

http://www.ncbi.nlm.nih.gov/#11113
type: UnificationXref
db: Entrez Gene
id: 11113

HMMR
type: Protein
entity reference: HMMR

shugoshin.family
type: Protein
data source: Spike
xref: ELK:F.000032
member physical entity: SGOL1
member physical entity: SGOL2

http://www.ncbi.nlm.nih.gov/#79866
type: UnificationXref
db: Entrez Gene
id: 79866

.Complex.CycA.Cdk2....INHIBITS.Complex.APC/C.CDC20...(ANAPC11).
type: Catalysis
controlled: Phosphorylation.I.CycA.Cdk2.APC/C.CDC20
control type: INHIBITION
data source: Spike
controller: CycA-Cdk2
xref: 19364923

.AURKA.INHIBITS.RASSF1.
type: Catalysis
controlled: Phosphorylation.I.AURKA.RASSF1
control type: INHIBITION
data source: Spike
controller: AURKA
xref: 19276349

15024056
type: PublicationXref
title: Forkhead box M1B transcriptional activity requires binding of Cdk-cyclin complexes for phosphorylation-dependent recruitment of p300/CBP coactivators
db: PubMed
id: 15024056

.Complex.Mitotic.Spindle..CDCA8,.PRC1..PROMOTES.Complex.centromere.kinetochore..CENPF,.CENPB,.CENPE,.CENPA,.TACC2,.TACC3.(CENPE).
type: Catalysis
controlled: Other.P.Mitotic.Spindle.centromere.kinetochore
control type: ACTIVATION
data source: Spike
controller: Mitotic Spindle
xref: 12600307

KIF4A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#24137

http://www.ncbi.nlm.nih.gov/#5594
type: UnificationXref
db: Entrez Gene
id: 5594

15625105
type: PublicationXref
title: Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis
db: PubMed
id: 15625105

CDK1_inactive
type: Protein
entity reference: CDK1

.Complex.CycB.Cdc2..CDK1,.Family.CycB..CCNB1,.CCNB2...INHIBITS.Family.Lamins...(LMNA).
type: Catalysis
controlled: Phosphorylation.I.CycB.Cdc2.Lamins
control type: INHIBITION
data source: Spike
controller: CyclinB-Cdc2 (CDK1)- M-phase-promoting factor (MPF)
xref: 7925482
xref: 11766879

Translation
type: MolecularInteraction
participant: PLK1_inactive
participant: PLK1_RNA

ATM
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#472

8034666
type: PublicationXref
title: Identification of nuclear beta II protein kinase C as a mitotic lamin kinase
db: PubMed
id: 8034666

Cohesin.complex_inactive
type: Protein

SCF-beta-TrCP complex [cytosol]
type: Complex
display name: SCF-beta-TrCP.complex
data source: Spike

8428594
type: PublicationXref
title: Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis
db: PubMed
id: 8428594

http://www.ncbi.nlm.nih.gov/#5586
type: UnificationXref
db: Entrez Gene
id: 5586

http://www.ncbi.nlm.nih.gov/#4605
type: UnificationXref
db: Entrez Gene
id: 4605

.CFL1.INHIBITS.Family.Actin...(ACTC1).
type: Catalysis
controlled: Physical.Interaction.I.CFL1.Actin
control type: INHIBITION
data source: Spike
controller: CFL1
xref: 17196218

CDCA8
type: Protein
entity reference: CDCA8

Myo-II.complex_inactive
type: Protein

DIAPH3_inactive
type: Protein
entity reference: DIAPH3

CIT
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#11113

Translation
type: MolecularInteraction
participant: CCNB1_inactive
participant: CCNB1_RNA

18451105
type: PublicationXref
title: Chk1 and Claspin potentiate PCNA ubiquitination
db: PubMed
id: 18451105

CCNB2
type: Protein
entity reference: CCNB2

PRKC.family
type: Protein
data source: Spike
xref: TAU:F.329911
member physical entity: PKN2

15272308
type: PublicationXref
title: Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism
db: PubMed
id: 15272308

CFL1_inactive
type: Protein
entity reference: CFL1

CHEK1
type: Protein
entity reference: CHEK1

.AURKA.PROMOTES.PLK1.
type: Catalysis
controlled: Phosphorylation.P.AURKA.PLK1
control type: ACTIVATION
data source: Spike
controller: AURKA
xref: 19228686

11572993
type: PublicationXref
title: Increased levels of forkhead box M1B transcription factor in transgenic mouse hepatocytes prevent age-related proliferation defects in regenerating liver
db: PubMed
id: 11572993

15531365
type: PublicationXref
title: The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis
db: PubMed
id: 15531365

CHEK2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#11200

15163406
type: PublicationXref
title: Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase
db: PubMed
id: 15163406

http://www.ncbi.nlm.nih.gov/#6093
type: UnificationXref
db: Entrez Gene
id: 6093

http://www.ncbi.nlm.nih.gov/#545
type: UnificationXref
db: Entrez Gene
id: 545

MYBL2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4605

MYBL2_inactive
type: Protein
entity reference: MYBL2

.TTK.PROMOTES.TACC2.
type: Catalysis
controlled: Phosphorylation.P.TTK.TACC2
control type: ACTIVATION
data source: Spike
controller: TTK
xref: 15304323

Lamins.family_inactive
type: Protein

11897663
type: PublicationXref
title: Plk1 promotes nuclear translocation of human Cdc25C during prophase
db: PubMed
id: 11897663

9001210
type: PublicationXref
title: The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex
db: PubMed
id: 9001210

CyclinB-Cdc2 (CDK1)- M-phase-promoting factor (MPF)
type: Complex
display name: CycB-Cdc2.complex
data source: Spike
component: CDK1
component: CycB.family

http://www.ncbi.nlm.nih.gov/#9055
type: UnificationXref
db: Entrez Gene
id: 9055

http://www.ncbi.nlm.nih.gov/#6790
type: UnificationXref
db: Entrez Gene
id: 6790

RASSF1_inactive
type: Protein
entity reference: RASSF1

.PTTG1.INHIBITS.ESPL1.
type: Catalysis
controlled: Other.I.PTTG1.ESPL1
control type: INHIBITION
data source: Spike
controller: PTTG1
xref: 15678131

.CDC25C.PROMOTES.Complex.CycB.Cdc2..CDK1,.Family.CycB..CCNB1,.CCNB2...
type: Catalysis
controlled: Dephosphorylation.P.CDC25C.CycB.Cdc2
control type: ACTIVATION
data source: Spike
controller: CDC25C
xref: 18319725
xref: 8348613

.TTK.INHIBITS.Complex.Mitotic.Spindle..CDCA8,.PRC1.(PRC1).
type: Catalysis
controlled: Phosphorylation.I.TTK.Mitotic.Spindle
control type: INHIBITION
data source: Spike
controller: TTK
xref: 12686615
xref: 14657364

16439210
type: PublicationXref
title: The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1
db: PubMed
id: 16439210

.ATR.INHIBITS.PLK1.
type: Catalysis
controlled: Indirect.I.ATR.PLK1
control type: INHIBITION
data source: Spike
controller: ATR
xref: 12147700

10716937
type: PublicationXref
title: Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction
db: PubMed
id: 10716937

Spike
type: Provenance

15070733
type: PublicationXref
title: M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP
db: PubMed
id: 15070733

http://www.ncbi.nlm.nih.gov/#29127
type: UnificationXref
db: Entrez Gene
id: 29127

PKMYT1_inactive
type: Protein
entity reference: PKMYT1

TACC3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#10460

http://www.ncbi.nlm.nih.gov/#998
type: UnificationXref
db: Entrez Gene
id: 998

http://www.ncbi.nlm.nih.gov/#995
type: UnificationXref
db: Entrez Gene
id: 995

PTTG1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9232

CDC25B
type: Protein
entity reference: CDC25B

http://www.ncbi.nlm.nih.gov/#994
type: UnificationXref
db: Entrez Gene
id: 994

http://www.ncbi.nlm.nih.gov/#993
type: UnificationXref
db: Entrez Gene
id: 993

.Complex.SCF.beta.TrCP....INHIBITS.WEE1.
type: Catalysis
controlled: Ubiquitination.I.SCF.beta.TrCP.WEE1
control type: INHIBITION
data source: Spike
controller: SCF-beta-TrCP complex [cytosol]
xref: 18285803

ROCK1_inactive
type: Protein
entity reference: ROCK1

WEE1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7465

.CLSPN.PROMOTES.CHEK1.
type: Catalysis
controlled: Other.P.CLSPN.CHEK1
control type: ACTIVATION
data source: Spike
controller: CLSPN
xref: 15371427
xref: 15279790
xref: 18451105

CENPB
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1059

CDK1_DNA
type: DnaRegion
entity reference: CDK1

.CHEK2.INHIBITS.CDC25C.
type: Catalysis
controlled: Phosphorylation.I.CHEK2.CDC25C
control type: INHIBITION
data source: Spike
controller: CHEK2
xref: 10681541

14-3-3.family
type: Protein
data source: Spike
xref: CEN:F.329881

16647857
type: PublicationXref
title: Ubiquitin and SUMO systems in the regulation of mitotic checkpoints
db: PubMed
id: 16647857

http://www.ncbi.nlm.nih.gov/#983
type: UnificationXref
db: Entrez Gene
id: 983

CDC25A_inactive
type: Protein
entity reference: CDC25A

.FOXM1.PROMOTES.CCNB1.
type: TemplateReactionRegulation
xref: 15689977
xref: 11682060
xref: 15817462
xref: 11572993
xref: 10567581
xref: 11391529
controlled: Transcription.Regulation.P.FOXM1.CCNB1
control type: ACTIVATION
data source: Spike
controller: FOXM1

http://www.ncbi.nlm.nih.gov/#63967
type: UnificationXref
db: Entrez Gene
id: 63967

http://www.ncbi.nlm.nih.gov/#5347
type: UnificationXref
db: Entrez Gene
id: 5347

WEE1_inactive
type: Protein
entity reference: WEE1

8079118
type: PublicationXref
title: Dentofacial morphology in adolescent or early adult patients with cleft lip and palate after a treatment regimen that included vomer flap surgery and pushback palatal repair
db: PubMed
id: 8079118

http://www.ncbi.nlm.nih.gov/#472
type: UnificationXref
db: Entrez Gene
id: 472

CDC42EP4
type: Protein
entity reference: CDC42EP4

RHOA
type: Protein
entity reference: RHOA

12049736
type: PublicationXref
title: Phosphorylation on tyrosine-15 of p34(Cdc2) by ErbB2 inhibits p34(Cdc2) activation and is involved in resistance to taxol-induced apoptosis
db: PubMed
id: 12049736

10567581
type: PublicationXref
title: Premature expression of the winged helix transcription factor HFH-11B in regenerating mouse liver accelerates hepatocyte entry into S phase
db: PubMed
id: 10567581

http://www.ncbi.nlm.nih.gov/#9088
type: UnificationXref
db: Entrez Gene
id: 9088

.ESPL1.INHIBITS.Complex.Cohesin...(SMC1A).
type: Catalysis
controlled: Other.I.ESPL1.Cohesin
control type: INHIBITION
data source: Spike
controller: ESPL1
xref: 11146641

CycB.family
type: Protein
data source: Spike
xref: CEN:F.329953
member physical entity: CCNB1
member physical entity: CCNB2

http://www.ncbi.nlm.nih.gov/#55143
type: UnificationXref
db: Entrez Gene
id: 55143

.Complex.CycB.Cdc2..CDK1,.Family.CycB..CCNB1,.CCNB2...INHIBITS.PRC1.
type: Catalysis
controlled: Phosphorylation.I.CycB.Cdc2.PRC1
control type: INHIBITION
data source: Spike
controller: CyclinB-Cdc2 (CDK1)- M-phase-promoting factor (MPF)
xref: 15774750

ECT2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1894

.ATM.PROMOTES.CHEK2.
type: Catalysis
controlled: Phosphorylation.P.ATM.CHEK2
control type: ACTIVATION
data source: Spike
controller: ATM
xref: 12773400
xref: 9889122

.Complex.CycB.Cdc2..CDK1,.Family.CycB..CCNB1,.CCNB2...PROMOTES.CDC25C.
type: Catalysis
controlled: Phosphorylation.P.CycB.Cdc2.CDC25C
control type: ACTIVATION
data source: Spike
controller: CyclinB-Cdc2 (CDK1)- M-phase-promoting factor (MPF)
xref: 8428594

C13orf34
type: Protein
entity reference: C13orf34

12963707
type: PublicationXref
title: NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization
db: PubMed
id: 12963707

CDCA3_inactive
type: Protein
entity reference: CDCA3

.CFL2.PROMOTES.Family.Actin...(ACTC1).
type: Catalysis
controlled: Physical.Interaction.P.CFL2.Actin
control type: ACTIVATION
data source: Spike
controller: CFL2
xref: 16530787
xref: 18957424

MAPK1
type: Protein
entity reference: MAPK1

TTK
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7272

11756469
type: PublicationXref
title: CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis
db: PubMed
id: 11756469

RACGAP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#29127

.Complex.CycB.Cdc2..CDK1,.Family.CycB..CCNB1,.CCNB2...INHIBITS.Complex.RFC...(RFC1).
type: Catalysis
controlled: Phosphorylation.I.CycB.Cdc2.RFC
control type: INHIBITION
data source: Spike
controller: CyclinB-Cdc2 (CDK1)- M-phase-promoting factor (MPF)
xref: 12947101

http://www.ncbi.nlm.nih.gov/#387
type: UnificationXref
db: Entrez Gene
id: 387

.ROCK1.PROMOTES.Complex.Myo.II...(MYH10).
type: Catalysis
controlled: Other.P.ROCK1.Myo.II
control type: ACTIVATION
data source: Spike
controller: ROCK1
xref: 15774750

15304323
type: PublicationXref
title: TTK kinase is essential for the centrosomal localization of TACC2
db: PubMed
id: 15304323

.Complex.CycB.Cdc2..CDK1,.Family.CycB..CCNB1,.CCNB2...PROMOTES.Complex.APC/C.CDC20...(CDC20).
type: Catalysis
controlled: Phosphorylation.P.CycB.Cdc2.APC/C.CDC20
control type: ACTIVATION
data source: Spike
controller: CyclinB-Cdc2 (CDK1)- M-phase-promoting factor (MPF)
xref: 15678131

BUB1
type: Protein
entity reference: BUB1

CDCA8
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#55143

15678131
type: PublicationXref
title: The anaphase-promoting complex: a key factor in the regulation of cell cycle
db: PubMed
id: 15678131

9889122
type: PublicationXref
title: A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
db: PubMed
id: 9889122

PKN2_inactive
type: Protein
entity reference: PKN2

CDC25C_inactive
type: Protein
entity reference: CDC25C

.Complex.APC/C.FZR1....INHIBITS.AURKB.
type: Catalysis
controlled: Ubiquitination.I.APC/C.FZR1.AURKB
control type: INHIBITION
data source: Spike
controller: Anaphase promoting complex / FZR1(CDH1) activator
xref: 16647857

.TTK.PROMOTES.CDCA8.
type: Catalysis
controlled: Phosphorylation.P.TTK.CDCA8
control type: ACTIVATION
data source: Spike
controller: TTK
xref: 19228686

CCNB1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#891

18285803
type: PublicationXref
title: Regulation of DNA repair throughout the cell cycle
db: PubMed
id: 18285803

15128871
type: PublicationXref
title: Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition
db: PubMed
id: 15128871

ELK:F.000032
type: UnificationXref
db: Spike DB
id: ELK:F-000032

C13orf34
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#79866

.RASSF1.INHIBITS.Complex.APC/C.CDC20...(CDC20).
type: Catalysis
controlled: Physical.Interaction.I.RASSF1.APC/C.CDC20
control type: INHIBITION
data source: Spike
controller: RASSF1
xref: 19276349

.ATR.PROMOTES.CHEK1.
type: Catalysis
controlled: Phosphorylation.P.ATR.CHEK1
control type: ACTIVATION
data source: Spike
controller: ATR
xref: 16431910
xref: 15279789
xref: 12766152
xref: 12781359
xref: 15190204
xref: 15272308
xref: 10859164
xref: 10859163
xref: 16360315
xref: 11090622
xref: 11390642

ELK:F.000030
type: UnificationXref
db: Spike DB
id: ELK:F-000030

15774750
type: PublicationXref
title: The molecular requirements for cytokinesis
db: PubMed
id: 15774750

SGOL2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#151246

HMMR
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3161

.Complex.CycB.Cdc2..CDK1,.Family.CycB..CCNB1,.CCNB2...INHIBITS.WEE1.
type: Catalysis
controlled: Phosphorylation.I.CycB.Cdc2.WEE1
control type: INHIBITION
data source: Spike
controller: CyclinB-Cdc2 (CDK1)- M-phase-promoting factor (MPF)
xref: 15070733

LIMK1
type: Protein
entity reference: LIMK1

Mitotic Spindle
type: Complex
display name: Mitotic Spindle.complex
data source: Spike
component: PRC1
component: CDCA8

.Complex.APC/C.FZR1....INHIBITS.AURKA.
type: Catalysis
controlled: Ubiquitination.I.APC/C.FZR1.AURKA
control type: INHIBITION
data source: Spike
controller: Anaphase promoting complex / FZR1(CDH1) activator
xref: 16647857

CCNB1
type: Protein
entity reference: CCNB1

.PLK1.INHIBITS.CLSPN.
type: Catalysis
controlled: Phosphorylation.I.PLK1.CLSPN
control type: INHIBITION
data source: Spike
controller: PLK1
xref: 15163406

18957424
type: PublicationXref
title: Actin depolymerization factor/cofilin activation regulates actin polymerization and tension development in canine tracheal smooth muscle
db: PubMed
id: 18957424

CDC25B
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#994

CDCA3
type: Protein
entity reference: CDCA3

Nonmuscle myosin II
type: Complex
display name: Myo-II.complex
data source: Spike

12686615
type: PublicationXref
title: Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores
db: PubMed
id: 12686615

.Complex.APC/C.FZR1....INHIBITS.CDC25A.
type: Catalysis
controlled: Ubiquitination.I.APC/C.FZR1.CDC25A
control type: INHIBITION
data source: Spike
controller: Anaphase promoting complex / FZR1(CDH1) activator
xref: 16647857

.FOXM1.PROMOTES.PLK1.
type: TemplateReactionRegulation
xref: 15689977
xref: 16314512
xref: 15654331
xref: 17173139
xref: 15817462
xref: 16809346
xref: 15531365
controlled: Transcription.Regulation.P.FOXM1.PLK1
control type: ACTIVATION
data source: Spike
controller: FOXM1

15817462
type: PublicationXref
title: The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature
db: PubMed
id: 15817462

CDC42
type: Protein
entity reference: CDC42

.PLK1.PROMOTES.ECT2.
type: Catalysis
controlled: mRNA.stability.P.PLK1.ECT2
control type: ACTIVATION
data source: Spike
controller: PLK1
xref: 17332740

CDCA3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#83461

CycB-Cdc2.complex_inactive
type: Protein

PP1 (Protein Phosphatase 1)
type: Complex
display name: PP1.complex
data source: Spike

RHOA_inactive
type: Protein
entity reference: RHOA

.KIF4A.PROMOTES.PRC1.
type: Catalysis
controlled: Other.P.KIF4A.PRC1
control type: ACTIVATION
data source: Spike
controller: KIF4A
xref: 15625105

18309293
type: PublicationXref
title: Plx1 is required for chromosomal DNA replication under stressful conditions
db: PubMed
id: 18309293

CENPB
type: Protein
entity reference: CENPB

ROCK1
type: Protein
entity reference: ROCK1

CFL2_inactive
type: Protein
entity reference: CFL2

http://www.ncbi.nlm.nih.gov/#151246
type: UnificationXref
db: Entrez Gene
id: 151246

Cohesin (mytotic)
type: Complex
display name: Cohesin.complex
data source: Spike

CDC25B_inactive
type: Protein
entity reference: CDC25B

.PLK1.PROMOTES.CDC25C.
type: Catalysis
controlled: Phosphorylation.P.PLK1.CDC25C
control type: ACTIVATION
data source: Spike
controller: PLK1
xref: 11897663

Translation
type: MolecularInteraction
participant: CDC25A_inactive
participant: CDC25A_RNA

CENPA
type: Protein
entity reference: CENPA

RHOA
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#387

20126263
type: PublicationXref
title: A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G(2)/M DNA Damage Checkpoint
db: PubMed
id: 20126263

19364923
type: PublicationXref
title: The decision to enter mitosis: feedback and redundancy in the mitotic entry network
db: PubMed
id: 19364923

11390642
type: PublicationXref
title: ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
db: PubMed
id: 11390642

CIT_inactive
type: Protein
entity reference: CIT

.Complex.CycA.Cdk2....INHIBITS.Complex.APC/C.FZR1...(CDC23).
type: Catalysis
controlled: Phosphorylation.I.CycA.Cdk2.APC/C.FZR1
control type: INHIBITION
data source: Spike
controller: CycA-Cdk2
xref: 11340163

CDC25B_DNA
type: DnaRegion
entity reference: CDC25B

10681541
type: PublicationXref
title: The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01
db: PubMed
id: 10681541

PKN2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5586

TACC2
type: Protein
entity reference: TACC2

CKS2
type: Protein
entity reference: CKS2

http://www.ncbi.nlm.nih.gov/#2305
type: UnificationXref
db: Entrez Gene
id: 2305

ERBB2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2064

.ATR.PROMOTES.ATM.
type: Catalysis
controlled: Phosphorylation.P.ATR.ATM
control type: ACTIVATION
data source: Spike
controller: ATR
xref: 17124492

AURKA_inactive
type: Protein
entity reference: AURKA

.Complex.APC/C.FZR1....INHIBITS.CDCA3.
type: Catalysis
controlled: Ubiquitination.I.APC/C.FZR1.CDCA3
control type: INHIBITION
data source: Spike
controller: Anaphase promoting complex / FZR1(CDH1) activator
xref: 15678131

12773400
type: PublicationXref
title: A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein
db: PubMed
id: 12773400

.CHEK1.INHIBITS.CDC25C.
type: Catalysis
controlled: Phosphorylation.I.CHEK1.CDC25C
control type: INHIBITION
data source: Spike
controller: CHEK1
xref: 10681541

.Family.14.3.3....INHIBITS.CDC25C.
type: Catalysis
controlled: Physical.Interaction.I.14.3.3.CDC25C
control type: INHIBITION
data source: Spike
controller: 14-3-3.family
xref: 12764136
xref: 10323858

CDC25A_RNA
type: RnaRegion
entity reference: CDC25A

12909615
type: PublicationXref
title: Karyopherin-alpha2 protein interacts with Chk2 and contributes to its nuclear import
db: PubMed
id: 12909615

.KPNA2.PROMOTES.CHEK2.
type: Catalysis
controlled: Other.P.KPNA2.CHEK2
control type: ACTIVATION
data source: Spike
controller: KPNA2
xref: 12909615

CDK1_RNA
type: RnaRegion
entity reference: CDK1

14657364
type: PublicationXref
title: Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression
db: PubMed
id: 14657364

MAPK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5594

15733663
type: PublicationXref
title: APC/C-Cdc20-mediated degradation of cyclin B participates in CSF arrest in unfertilized Xenopus eggs
db: PubMed
id: 15733663

FBXO5
type: Protein
entity reference: FBXO5

.FBXO5.INHIBITS.Complex.APC/C.CDC20...(ANAPC11).
type: Catalysis
controlled: Physical.Interaction.I.FBXO5.APC/C.CDC20
control type: INHIBITION
data source: Spike
controller: FBXO5
xref: 16439210

PTTG1_inactive
type: Protein
entity reference: PTTG1

PLK1
type: Protein
entity reference: PLK1

9094315
type: PublicationXref
title: Phosphorylation and activation of B-Myb by cyclin A-Cdk2
db: PubMed
id: 9094315

.ATR.INHIBITS.CLSPN.
type: Catalysis
controlled: Phosphorylation.I.ATR.CLSPN
control type: INHIBITION
data source: Spike
controller: ATR
xref: 18077418
xref: 18309293

.Complex.APC/C.FZR1....INHIBITS.CCNB1.
type: Catalysis
controlled: Ubiquitination.I.APC/C.FZR1.CCNB1
control type: INHIBITION
data source: Spike
controller: Anaphase promoting complex / FZR1(CDH1) activator
xref: 19160489

C13orf34_inactive
type: Protein
entity reference: C13orf34

TPX2_inactive
type: Protein
entity reference: TPX2

Lamins.family
type: Protein
data source: Spike
xref: CEN:F.329959

.Family.14.3.3....INHIBITS.CDC25B.
type: Catalysis
controlled: Physical.Interaction.I.14.3.3.CDC25B
control type: INHIBITION
data source: Spike
controller: 14-3-3.family
xref: 10323858

17124492
type: PublicationXref
title: ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling
db: PubMed
id: 17124492

http://www.ncbi.nlm.nih.gov/#51203
type: UnificationXref
db: Entrez Gene
id: 51203

HMMR_inactive
type: Protein
entity reference: HMMR

.ECT2.PROMOTES.RHOA.
type: Catalysis
controlled: Other.P.ECT2.RHOA
control type: ACTIVATION
data source: Spike
controller: ECT2
xref: 15774750

ATM_inactive
type: Protein
entity reference: ATM

Actin.family_inactive
type: Protein

15642749
type: PublicationXref
title: Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis
db: PubMed
id: 15642749

Translation
type: MolecularInteraction
participant: CDK1_inactive
participant: CDK1_RNA

11766879
type: PublicationXref
title: Dynamics of the nuclear envelope at mitosis and during apoptosis
db: PubMed
id: 11766879

15525512
type: PublicationXref
title: Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint
db: PubMed
id: 15525512

CDC25A_DNA
type: DnaRegion
entity reference: CDC25A

PLK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5347

CDC25A
type: Protein
entity reference: CDC25A

CDCA8_inactive
type: Protein
entity reference: CDCA8

.RHOA.PROMOTES.PKN2.
type: Catalysis
controlled: Physical.Interaction.P.RHOA.PKN2
control type: ACTIVATION
data source: Spike
controller: RHOA
xref: 18835241

10323858
type: PublicationXref
title: Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25
db: PubMed
id: 10323858

15654331
type: PublicationXref
title: FoxM1 is required for execution of the mitotic programme and chromosome stability
db: PubMed
id: 15654331

11391529
type: PublicationXref
title: Earlier expression of the transcription factor HFH-11B diminishes induction of p21(CIP1/WAF1) levels and accelerates mouse hepatocyte entry into S-phase following carbon tetrachloride liver injury
db: PubMed
id: 11391529

CFL1
type: Protein
entity reference: CFL1

16431910
type: PublicationXref
title: Rapid activation of ATR by ionizing radiation requires ATM and Mre11
db: PubMed
id: 16431910

15190208
type: PublicationXref
title: A new look at Rho GTPases in cell cycle: role in kinetochore-microtubule attachment
db: PubMed
id: 15190208

.LIMK1.PROMOTES.CFL2.
type: Catalysis
controlled: Phosphorylation.P.LIMK1.CFL2
control type: ACTIVATION
data source: Spike
controller: LIMK1
xref: 8079118

CCNB1_RNA
type: RnaRegion
entity reference: CCNB1

http://www.ncbi.nlm.nih.gov/#22974
type: UnificationXref
db: Entrez Gene
id: 22974

TPX2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#22974

PLK1_DNA
type: DnaRegion
entity reference: PLK1

15190204
type: PublicationXref
title: ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage
db: PubMed
id: 15190204

19160488
type: PublicationXref
title: Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression
db: PubMed
id: 19160488

http://www.ncbi.nlm.nih.gov/#1111
type: UnificationXref
db: Entrez Gene
id: 1111

CHEK1_inactive
type: Protein
entity reference: CHEK1

CENPE
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1062

19160489
type: PublicationXref
title: The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory
db: PubMed
id: 19160489

11090622
type: PublicationXref
title: Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts
db: PubMed
id: 11090622

NUSAP1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#51203

.RHOA.PROMOTES.CIT.
type: Catalysis
controlled: Physical.Interaction.P.RHOA.CIT
control type: ACTIVATION
data source: Spike
controller: RHOA
xref: 17332740

9606
type: UnificationXref
db: taxonomy
id: 9606

11018042
type: PublicationXref
title: Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase
db: PubMed
id: 11018042

KPNA2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3838

.MYBL2.PROMOTES.CDK1.
type: TemplateReactionRegulation
xref: 15510213
controlled: Transcription.Regulation.P.MYBL2.CDK1
control type: ACTIVATION
data source: Spike
controller: MYBL2

TACC2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#10579

.AURKA.PROMOTES.TPX2.
type: Catalysis
controlled: Phosphorylation.P.AURKA.TPX2
control type: ACTIVATION
data source: Spike
controller: AURKA
xref: 15630414

.MAPK1.INHIBITS.CDK1.
type: Catalysis
controlled: Phosphorylation.I.MAPK1.CDK1
control type: INHIBITION
data source: Spike
controller: MAPK1
xref: 17205132

.LIMK1.PROMOTES.CFL1.
type: Catalysis
controlled: Phosphorylation.P.LIMK1.CFL1
control type: ACTIVATION
data source: Spike
controller: LIMK1
xref: 8079118

10490598
type: PublicationXref
title: The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins
db: PubMed
id: 10490598

CEN:F.329953
type: UnificationXref
db: Spike DB
id: CEN:F-329953

TACC3
type: Protein
entity reference: TACC3

AURKB_DNA
type: DnaRegion
entity reference: AURKB

CFL2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1073

ROCK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#6093

.WEE1.INHIBITS.Complex.CycB.Cdc2..CDK1,.Family.CycB..CCNB1,.CCNB2...
type: Catalysis
controlled: Phosphorylation.I.WEE1.CycB.Cdc2
control type: INHIBITION
data source: Spike
controller: WEE1
xref: 8348613

http://www.ncbi.nlm.nih.gov/#3161
type: UnificationXref
db: Entrez Gene
id: 3161

RASSF1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#11186

17196218
type: PublicationXref
title: Mapping the ADF/cofilin binding site on monomeric actin by competitive cross-linking and peptide array: evidence for a second binding site on monomeric actin
db: PubMed
id: 17196218

CDC25C
type: Protein
entity reference: CDC25C

CCNB1_inactive
type: Protein
entity reference: CCNB1

CCNB2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9133

12764136
type: PublicationXref
title: 14-3-3 acts as an intramolecular bridge to regulate cdc25B localization and activity
db: PubMed
id: 12764136

NF-Y (trimer) transcription factor
type: Complex
display name: NF-Y.complex
data source: Spike

PRC1
type: Protein
entity reference: PRC1

CEN:F.329959
type: UnificationXref
db: Spike DB
id: CEN:F-329959

16530787
type: PublicationXref
title: Cofilin cross-bridges adjacent actin protomers and replaces part of the longitudinal F-actin interface
db: PubMed
id: 16530787

PKMYT1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9088

MYBL2
type: Protein
entity reference: MYBL2

BUB1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#699

CycA-Cdk2
type: Complex
display name: CycA-Cdk2.complex
data source: Spike

CDK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#983

CCNF
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#899

.Complex.CycA.Cdk2....PROMOTES.FOXM1.
type: Catalysis
controlled: Phosphorylation.P.CycA.Cdk2.FOXM1
control type: ACTIVATION
data source: Spike
controller: CycA-Cdk2
xref: 15024056

DIAPH3
type: Protein
entity reference: DIAPH3

CDC25A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#993

http://www.ncbi.nlm.nih.gov/#3984
type: UnificationXref
db: Entrez Gene
id: 3984

.TPX2.UNKNOWN.HMMR.
type: Catalysis
controlled: Physical.Interaction.U.TPX2.HMMR
control type: ACTIVATION_UNKMECH
data source: Spike
controller: TPX2
xref: 15705883

12482952
type: PublicationXref
title: The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration
db: PubMed
id: 12482952

ECT2_inactive
type: Protein
entity reference: ECT2

16809346
type: PublicationXref
title: The Forkhead box M1 protein regulates the transcription of the estrogen receptor alpha in breast cancer cells
db: PubMed
id: 16809346

.CDC42.PROMOTES.DIAPH3.
type: Catalysis
controlled: Other.P.CDC42.DIAPH3
control type: ACTIVATION
data source: Spike
controller: CDC42
xref: 15190208

TTK
type: Protein
entity reference: TTK

PKN2
type: Protein
entity reference: PKN2

FOXM1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#2305

9281587
type: PublicationXref
title: A dual-specificity phosphatase Cdc25B is an unstable protein and triggers p34(cdc2)/cyclin B activation in hamster BHK21 cells arrested with hydroxyurea
db: PubMed
id: 9281587

17173139
type: PublicationXref
title: A cell-penetrating ARF peptide inhibitor of FoxM1 in mouse hepatocellular carcinoma treatment
db: PubMed
id: 17173139

http://www.ncbi.nlm.nih.gov/#23580
type: UnificationXref
db: Entrez Gene
id: 23580

PLK1_RNA
type: RnaRegion
entity reference: PLK1

.CDC25A.PROMOTES.Complex.CycB.Cdc2..CDK1,.Family.CycB..CCNB1,.CCNB2..(CDK1).
type: Catalysis
controlled: Dephosphorylation.P.CDC25A.CycB.Cdc2
control type: ACTIVATION
data source: Spike
controller: CDC25A
xref: 19364923

KIF4A
type: Protein
entity reference: KIF4A

.NUSAP1.PROMOTES.Complex.Mitotic.Spindle..CDCA8,.PRC1.(CDCA8).
type: Catalysis
controlled: Other.P.NUSAP1.Mitotic.Spindle
control type: ACTIVATION
data source: Spike
controller: NUSAP1
xref: 12963707

Translation
type: MolecularInteraction
participant: CDC25B_RNA
participant: CDC25B_inactive

.CCNF.PROMOTES.Complex.CycB.Cdc2..CDK1,.Family.CycB..CCNB1,.CCNB2...
type: Catalysis
controlled: Physical.Interaction.P.CCNF.CycB.Cdc2
control type: ACTIVATION
data source: Spike
controller: CCNF
xref: 10716937

.PLK1.INHIBITS.WEE1.
type: Catalysis
controlled: Phosphorylation.I.PLK1.WEE1
control type: INHIBITION
data source: Spike
controller: PLK1
xref: 18285803

.CKS2.PROMOTES.Complex.centromere.kinetochore..CENPF,.CENPB,.CENPE,.CENPA,.TACC2,.TACC3.(CENPE).
type: Catalysis
controlled: Physical.Interaction.P.CKS2.centromere.kinetochore
control type: ACTIVATION
data source: Spike
controller: CKS2
xref: 12714746

15705883
type: PublicationXref
title: Receptor for hyaluronan-mediated motility correlates with centrosome abnormalities in multiple myeloma and maintains mitotic integrity
db: PubMed
id: 15705883

.Complex.APC/C.FZR1....INHIBITS.CLSPN.
type: Catalysis
controlled: Ubiquitination.I.APC/C.FZR1.CLSPN
control type: INHIBITION
data source: Spike
controller: Anaphase promoting complex / FZR1(CDH1) activator
xref: 19680264

CDC42EP4_inactive
type: Protein
entity reference: CDC42EP4

15689977
type: PublicationXref
title: FoxM1 dances with mitosis
db: PubMed
id: 15689977

18319725
type: PublicationXref
title: A comprehensive modular map of molecular interactions in RB/E2F pathway
db: PubMed
id: 18319725

18077418
type: PublicationXref
title: Profiling of UV-induced ATM/ATR signaling pathways
db: PubMed
id: 18077418

.ECT2.PROMOTES.CDC42.
type: Catalysis
controlled: Other.P.ECT2.CDC42
control type: ACTIVATION
data source: Spike
controller: ECT2
xref: 15642749

10095772
type: PublicationXref
title: Identification of cyclin A/Cdk2 phosphorylation sites in B-Myb
db: PubMed
id: 10095772

.PLK1.PROMOTES.FOXM1.
type: Catalysis
controlled: Phosphorylation.P.PLK1.FOXM1
control type: ACTIVATION
data source: Spike
controller: PLK1
xref: 19160488

Activated APC/C (complexed with the cdc20 activator)
type: Complex
display name: APC/C-CDC20.complex
data source: Spike

Cytokinesis Contractile Ring
type: Complex
display name: contractile ring.complex
data source: Spike
component: Actin.family

12781359
type: PublicationXref
title: Chk1 and Chk2 kinases in checkpoint control and cancer
db: PubMed
id: 12781359

PKMYT1
type: Protein
entity reference: PKMYT1

.FOXM1.PROMOTES.CDC25B.
type: TemplateReactionRegulation
xref: 15689977
xref: 16314512
xref: 12482952
controlled: Transcription.Regulation.P.FOXM1.CDC25B
control type: ACTIVATION
data source: Spike
controller: FOXM1

CEN:F.329881
type: UnificationXref
db: Spike DB
id: CEN:F-329881

http://www.ncbi.nlm.nih.gov/#9232
type: UnificationXref
db: Entrez Gene
id: 9232

RASSF1
type: Protein
entity reference: RASSF1

http://www.ncbi.nlm.nih.gov/#1164
type: UnificationXref
db: Entrez Gene
id: 1164

TAU:F.329911
type: UnificationXref
db: Spike DB
id: TAU:F-329911

TACC2_inactive
type: Protein
entity reference: TACC2

7925482
type: PublicationXref
title: Functional analysis of phosphorylation sites in human lamin A controlling lamin disassembly, nuclear transport and assembly
db: PubMed
id: 7925482

15733861
type: PublicationXref
title: Cell-cycle-dependent regulation of the human and mouse Tome-1 promoters
db: PubMed
id: 15733861

http://www.ncbi.nlm.nih.gov/#11186
type: UnificationXref
db: Entrez Gene
id: 11186

.FOXM1.PROMOTES.CDC25A.
type: TemplateReactionRegulation
xref: 15689977
controlled: Transcription.Regulation.P.FOXM1.CDC25A
control type: ACTIVATION
data source: Spike
controller: FOXM1

WEE1
type: Protein
entity reference: WEE1

RACGAP1
type: Protein
entity reference: RACGAP1

11970886
type: PublicationXref
title: Chromosome segregation: playing polo in prophase
db: PubMed
id: 11970886

.PLK1.INHIBITS.PKMYT1.
type: Catalysis
controlled: Phosphorylation.I.PLK1.PKMYT1
control type: INHIBITION
data source: Spike
controller: PLK1
xref: 12738781

.AURKA.PROMOTES.CENPA.
type: Catalysis
controlled: Phosphorylation.P.AURKA.CENPA
control type: ACTIVATION
data source: Spike
controller: AURKA
xref: 14667408

18237113
type: PublicationXref
title: NanoLC-MS/MS analysis provides new insights into the phosphorylation pattern of Cdc25B in vivo: full overlap with sites of phosphorylation by Chk1 and Cdk1/cycB kinases in vitro
db: PubMed
id: 18237113

12147700
type: PublicationXref
title: ATR enforces the topoisomerase II-dependent G2 checkpoint through inhibition of Plk1 kinase
db: PubMed
id: 12147700

11682060
type: PublicationXref
title: Over-expression of FoxM1 stimulates cyclin B1 expression
db: PubMed
id: 11682060

PTTG1
type: Protein
entity reference: PTTG1

CDC42_inactive
type: Protein
entity reference: CDC42

15173575
type: PublicationXref
title: Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein
db: PubMed
id: 15173575

CHEK2
type: Protein
entity reference: CHEK2

.CFL2.INHIBITS.Family.Actin...(ACTC1).
type: Catalysis
controlled: Physical.Interaction.I.CFL2.Actin
control type: INHIBITION
data source: Spike
controller: CFL2
xref: 16530787
xref: 18957424

15371427
type: PublicationXref
title: Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1
db: PubMed
id: 15371427

ECT2
type: Protein
entity reference: ECT2

.Complex.PP1....INHIBITS.AURKA.
type: Catalysis
controlled: Dephosphorylation.I.PP1.AURKA
control type: INHIBITION
data source: Spike
controller: PP1 (Protein Phosphatase 1)
xref: 15173575

http://www.ncbi.nlm.nih.gov/#9212
type: UnificationXref
db: Entrez Gene
id: 9212

12766152
type: PublicationXref
title: Human claspin is required for replication checkpoint control
db: PubMed
id: 12766152

Protein phosphatase 2A
type: Complex
display name: PP2A.complex
data source: Spike

.Complex.Cohesin....UNKNOWN.Complex.centromere.kinetochore..CENPF,.CENPB,.CENPE,.CENPA,.TACC2,.TACC3.(CENPE).
type: Catalysis
controlled: Physical.Interaction.U.Cohesin.centromere.kinetochore
control type: ACTIVATION_UNKMECH
data source: Spike
controller: Cohesin (mytotic)
xref: 11970886

18835241
type: PublicationXref
title: The C-terminus of PRK2/PKNgamma is required for optimal activation by RhoA in a GTP-dependent manner
db: PubMed
id: 18835241

.CDC25B.PROMOTES.Complex.CycB.Cdc2..CDK1,.Family.CycB..CCNB1,.CCNB2..(CDK1).
type: Catalysis
controlled: Dephosphorylation.P.CDC25B.CycB.Cdc2
control type: ACTIVATION
data source: Spike
controller: CDC25B
xref: 9281587

.ROCK1.PROMOTES.LIMK1.
type: Catalysis
controlled: Phosphorylation.P.ROCK1.LIMK1
control type: ACTIVATION
data source: Spike
controller: ROCK1
xref: 11018042

12714746
type: PublicationXref
title: Requirement of Cks2 for the first metaphase/anaphase transition of mammalian meiosis
db: PubMed
id: 12714746

ERBB2
type: Protein
entity reference: ERBB2

FOXM1
type: Protein
entity reference: FOXM1

.FBXO5.INHIBITS.Complex.APC/C.FZR1...(FZR1).
type: Catalysis
controlled: Physical.Interaction.I.FBXO5.APC/C.FZR1
control type: INHIBITION
data source: Spike
controller: FBXO5
xref: 16439210