The N-terminal regulatory domain of cyclin A contains redundant ubiquitination targeting sequences and acceptor sites
E2Fs link the control of G1/S and G2/M transcription
Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A
Aurora A regulates prometaphase progression by inhibiting the ability of RASSF1A to suppress APC-Cdc20 activity
Kinase signaling in the spindle checkpoint
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice
Dissecting the role of ubiquitylation in the DNA damage response checkpoint in G2
Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase
Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase
CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate
Anaphase promoting complex / FZR1(CDH1) activator
Cell cycle-dependent phosphorylation of the large subunit of replication factor C (RF-C) leads to its dissociation from the RF-C complex
Claspin, a regulator of Chk1 in DNA replication stress pathway
A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression
Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and exit from cytokinesis
A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation
Chk1 in the DNA damage response: conserved roles from yeasts to mammals
Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling
Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response
The many substrates and functions of ATM
Forkhead box M1B transcriptional activity requires binding of Cdk-cyclin complexes for phosphorylation-dependent recruitment of p300/CBP coactivators
Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis
Identification of nuclear beta II protein kinase C as a mitotic lamin kinase
Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis
Chk1 and Claspin potentiate PCNA ubiquitination
Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism
Increased levels of forkhead box M1B transcription factor in transgenic mouse hepatocytes prevent age-related proliferation defects in regenerating liver
The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis
Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase
Plk1 promotes nuclear translocation of human Cdc25C during prophase
The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex
CyclinB-Cdc2 (CDK1)- M-phase-promoting factor (MPF)
The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1
Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction
M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP
Ubiquitin and SUMO systems in the regulation of mitotic checkpoints
Dentofacial morphology in adolescent or early adult patients with cleft lip and palate after a treatment regimen that included vomer flap surgery and pushback palatal repair
Phosphorylation on tyrosine-15 of p34(Cdc2) by ErbB2 inhibits p34(Cdc2) activation and is involved in resistance to taxol-induced apoptosis
Premature expression of the winged helix transcription factor HFH-11B in regenerating mouse liver accelerates hepatocyte entry into S phase
NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization
CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis
TTK kinase is essential for the centrosomal localization of TACC2
The anaphase-promoting complex: a key factor in the regulation of cell cycle
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
Regulation of DNA repair throughout the cell cycle
Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition
The molecular requirements for cytokinesis
Actin depolymerization factor/cofilin activation regulates actin polymerization and tension development in canine tracheal smooth muscle
Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores
The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature
Plx1 is required for chromosomal DNA replication under stressful conditions
A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G(2)/M DNA Damage Checkpoint
The decision to enter mitosis: feedback and redundancy in the mitotic entry network
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01
A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein
Karyopherin-alpha2 protein interacts with Chk2 and contributes to its nuclear import
Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression
APC/C-Cdc20-mediated degradation of cyclin B participates in CSF arrest in unfertilized Xenopus eggs
Phosphorylation and activation of B-Myb by cyclin A-Cdk2
ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling
Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis
Dynamics of the nuclear envelope at mitosis and during apoptosis
Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint
Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25
FoxM1 is required for execution of the mitotic programme and chromosome stability
Earlier expression of the transcription factor HFH-11B diminishes induction of p21(CIP1/WAF1) levels and accelerates mouse hepatocyte entry into S-phase following carbon tetrachloride liver injury
Rapid activation of ATR by ionizing radiation requires ATM and Mre11
A new look at Rho GTPases in cell cycle: role in kinetochore-microtubule attachment
ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage
Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression
The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory
Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts
Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase
The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins
Mapping the ADF/cofilin binding site on monomeric actin by competitive cross-linking and peptide array: evidence for a second binding site on monomeric actin
14-3-3 acts as an intramolecular bridge to regulate cdc25B localization and activity
Cofilin cross-bridges adjacent actin protomers and replaces part of the longitudinal F-actin interface
The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration
The Forkhead box M1 protein regulates the transcription of the estrogen receptor alpha in breast cancer cells
A dual-specificity phosphatase Cdc25B is an unstable protein and triggers p34(cdc2)/cyclin B activation in hamster BHK21 cells arrested with hydroxyurea
A cell-penetrating ARF peptide inhibitor of FoxM1 in mouse hepatocellular carcinoma treatment
Receptor for hyaluronan-mediated motility correlates with centrosome abnormalities in multiple myeloma and maintains mitotic integrity
A comprehensive modular map of molecular interactions in RB/E2F pathway
Profiling of UV-induced ATM/ATR signaling pathways
Identification of cyclin A/Cdk2 phosphorylation sites in B-Myb
Activated APC/C (complexed with the cdc20 activator)
Chk1 and Chk2 kinases in checkpoint control and cancer
Functional analysis of phosphorylation sites in human lamin A controlling lamin disassembly, nuclear transport and assembly
Cell-cycle-dependent regulation of the human and mouse Tome-1 promoters
Chromosome segregation: playing polo in prophase
NanoLC-MS/MS analysis provides new insights into the phosphorylation pattern of Cdc25B in vivo: full overlap with sites of phosphorylation by Chk1 and Cdk1/cycB kinases in vitro
ATR enforces the topoisomerase II-dependent G2 checkpoint through inhibition of Plk1 kinase
Over-expression of FoxM1 stimulates cyclin B1 expression
Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein
Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1
Human claspin is required for replication checkpoint control
The C-terminus of PRK2/PKNgamma is required for optimal activation by RhoA in a GTP-dependent manner
Requirement of Cks2 for the first metaphase/anaphase transition of mammalian meiosis