Translation
type: MolecularInteraction
participant: RB1_inactive
participant: RB1_RNA

Translation
type: MolecularInteraction
participant: PCNA_inactive
participant: PCNA_RNA

RBL1
type: Protein
entity reference: RBL1

CycA-Cdk2.complex_inactive
type: Protein

.MYBL2.PROMOTES.CCNB1.
type: TemplateReactionRegulation
control type: ACTIVATION
data source: Spike
xref: 15510213
controller: MYBL2
controlled: Transcription.Regulation.P.MYBL2.CCNB1

11491305
type: PublicationXref
title: Computer-assisted identification of cell cycle-related genes: new targets for E2F transcription factors.
id: 11491305
db: PubMed

15510213
type: PublicationXref
title: E2Fs link the control of G1/S and G2/M transcription
id: 15510213
db: PubMed

BTG2_DNA
type: DnaRegion
entity reference: BTG2

PCNA_RNA
type: RnaRegion
entity reference: PCNA

http://www.ncbi.nlm.nih.gov/#5111
type: UnificationXref
id: 5111
db: Entrez Gene

15467751
type: PublicationXref
title: Differential regulation of expression of the mammalian DNA repair genes by growth stimulation
id: 15467751
db: PubMed

CDKN1A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1026

CAF-1.complex_inactive
type: Protein

9858545
type: PublicationXref
title: p21(Waf1/Cip1) inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption
id: 9858545
db: PubMed

15678131
type: PublicationXref
title: The anaphase-promoting complex: a key factor in the regulation of cell cycle
id: 15678131
db: PubMed

DHFR_DNA
type: DnaRegion
entity reference: DHFR

CDC6_inactive
type: Protein
entity reference: CDC6

.UHRF1.PROMOTES.TOP2A.
type: TemplateReactionRegulation
control type: ACTIVATION
data source: Spike
xref: 10646863
xref: 12530060
controller: UHRF1
controlled: Transcription.Regulation.P.UHRF1.TOP2A

MYC
type: Protein
entity reference: MYC

PCNA_inactive
type: Protein
entity reference: PCNA

CCNE1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#898

12383116
type: PublicationXref
title: Highly potent p21(WAF1)-derived peptide inhibitors of CDK-mediated pRb phosphorylation: delineation and structural insight into their interactions with cyclin A
id: 12383116
db: PubMed

BLM
type: Protein
entity reference: BLM

YY1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7528

.Family.E2F1.3....PROMOTES.MCM10.
type: TemplateReactionRegulation
control type: ACTIVATION
data source: Spike
xref: 15195143
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.MCM10

CCNB1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#891

http://www.ncbi.nlm.nih.gov/#891
type: UnificationXref
id: 891
db: Entrez Gene

RAD51_DNA
type: DnaRegion
entity reference: RAD51

.Family.E2F1.3....PROMOTES.UHRF1.
type: TemplateReactionRegulation
control type: ACTIVATION
data source: Spike
xref: 15361834
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.UHRF1

http://www.ncbi.nlm.nih.gov/#894
type: UnificationXref
id: 894
db: Entrez Gene

TP53
type: Protein
entity reference: TP53

.CDKN1A.INHIBITS.Complex.CycA.Cdk2..CDK2..
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CDKN1A
xref: 12383116
controlled: Physical.Interaction.I.CDKN1A.CycA.Cdk2

MLH1
type: Protein
entity reference: MLH1

http://www.ncbi.nlm.nih.gov/#896
type: UnificationXref
id: 896
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#898
type: UnificationXref
id: 898
db: Entrez Gene

DHFR
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1719

RBL2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5934

pre_RC.complex_inactive
type: Protein

RFC1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5981

RFC1_inactive
type: Protein
entity reference: RFC1

CCNB1
type: Protein
entity reference: CCNB1

11118439
type: PublicationXref
title: Interaction between YY1 and the retinoblastoma protein. Regulation of cell cycle progression in differentiated cells.
id: 11118439
db: PubMed

HUS1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#3364

Translation
type: MolecularInteraction
participant: MCM10
participant: MCM10_RNA

http://www.ncbi.nlm.nih.gov/#51053
type: UnificationXref
id: 51053
db: Entrez Gene

17093053
type: PublicationXref
title: Global mapping of c-Myc binding sites and target gene networks in human B cells
id: 17093053
db: PubMed

Translation
type: MolecularInteraction
participant: BTG2
participant: BTG2_RNA

RAD9A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5883

MCM6_RNA
type: RnaRegion
entity reference: MCM6

8348613
type: PublicationXref
title: Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase
id: 8348613
db: PubMed

http://www.ncbi.nlm.nih.gov/#9133
type: UnificationXref
id: 9133
db: Entrez Gene

DHFR
type: Protein
entity reference: DHFR

CCND2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#894

TK1_RNA
type: RnaRegion
entity reference: TK1

CDK4_RNA
type: RnaRegion
entity reference: CDK4

E2F1_DNA
type: DnaRegion
entity reference: E2F1

CCNE1
type: Protein
entity reference: CCNE1

.Family.E2F1.3....PROMOTES.CCNB1.
type: TemplateReactionRegulation
control type: ACTIVATION
data source: Spike
xref: 15510213
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.CCNB1

RBL1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5933

15195143
type: PublicationXref
title: Expression of MCM10 and TopBP1 is regulated by cell proliferation and UV irradiation via the E2F transcription factor
id: 15195143
db: PubMed

MYC_RNA
type: RnaRegion
entity reference: MYC

.CDKN1A.INHIBITS.Complex.CycE.Cdk2..CCNE1,.CDK2.(CDK2).
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CDKN1A
xref: 9858545
controlled: Physical.Interaction.I.CDKN1A.CycE.Cdk2

CCNE1_RNA
type: RnaRegion
entity reference: CCNE1

http://www.ncbi.nlm.nih.gov/#7083
type: UnificationXref
id: 7083
db: Entrez Gene

CDKN2A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1029

Translation
type: MolecularInteraction
participant: CDC6_RNA
participant: CDC6_inactive

RB1_DNA
type: DnaRegion
entity reference: RB1

CCND1
type: Protein
entity reference: CCND1

APC/C-FZR1.complex_inactive
type: Protein

9520412
type: PublicationXref
title: Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells
id: 9520412
db: PubMed

RFC.complex
type: Complex
component: RFC1
data source: Spike
name: Replication Factor C

CDK1
type: Protein
entity reference: CDK1

DHFR_RNA
type: RnaRegion
entity reference: DHFR

.HUS1.PROMOTES.PCNA.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: HUS1
xref: 11077446
controlled: Physical.Interaction.P.HUS1.PCNA

Translation
type: MolecularInteraction
participant: E2F1_RNA
participant: E2F1

CCND1_inactive
type: Protein
entity reference: CCND1

RFC.complex_inactive
type: Protein

MLH1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4292

Translation
type: MolecularInteraction
participant: CDC25A
participant: CDC25A_RNA

E2F1_RNA
type: RnaRegion
entity reference: E2F1

.CDKN2A.INHIBITS.Complex.CycD.Cdk4..Family.CycD..CCND1,.CCND2,.CCND3.,.CDK4..
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CDKN2A
xref: 15459661
controlled: Physical.Interaction.I.CDKN2A.CycD.Cdk4

HUS1
type: Protein
entity reference: HUS1

MCM10_RNA
type: RnaRegion
entity reference: MCM10

CDC6_RNA
type: RnaRegion
entity reference: CDC6

8944033
type: PublicationXref
title: Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway
id: 8944033
db: PubMed

Translation
type: MolecularInteraction
participant: CCND1_RNA
participant: CCND1_inactive

http://www.ncbi.nlm.nih.gov/#7157
type: UnificationXref
id: 7157
db: Entrez Gene

GMNN
type: Protein
entity reference: GMNN

http://www.ncbi.nlm.nih.gov/#7153
type: UnificationXref
id: 7153
db: Entrez Gene

MLH1_DNA
type: DnaRegion
entity reference: MLH1

http://www.ncbi.nlm.nih.gov/#1869
type: UnificationXref
id: 1869
db: Entrez Gene

MCM6_DNA
type: DnaRegion
entity reference: MCM6

Translation
type: MolecularInteraction
participant: TOP2A
participant: TOP2A_RNA

.Family.E2F1.3....PROMOTES.MLH1.
type: TemplateReactionRegulation
control type: ACTIVATION
data source: Spike
xref: 15467751
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.MLH1

MYBL2_RNA
type: RnaRegion
entity reference: MYBL2

.Family.E2F1.3....PROMOTES.MYC.
type: TemplateReactionRegulation
control type: ACTIVATION
data source: Spike
xref: 11491305
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.MYC

Translation
type: MolecularInteraction
participant: TK1
participant: TK1_RNA

Translation
type: MolecularInteraction
participant: RAD51_RNA
participant: RAD51

E2F1-3.family_inactive
type: Protein

CDC25A_RNA
type: RnaRegion
entity reference: CDC25A

POLA1
type: Protein
entity reference: POLA1

CDC6
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#990

CDK1_RNA
type: RnaRegion
entity reference: CDK1

.BLM.PROMOTES.Complex.CAF.1...(CHAF1A).
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: BLM
xref: 15143166
controlled: Physical.Interaction.P.BLM.CAF.1

http://www.ncbi.nlm.nih.gov/#7832
type: UnificationXref
id: 7832
db: Entrez Gene

BTG2_RNA
type: RnaRegion
entity reference: BTG2

9889196
type: PublicationXref
title: Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization
id: 9889196
db: PubMed

POLA1_inactive
type: Protein
entity reference: POLA1

MCM5_RNA
type: RnaRegion
entity reference: MCM5

RFC1
type: Protein
entity reference: RFC1

.Complex.CycA.Cdk2..CDK2..INHIBITS.CDC6.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CycA-Cdk2.complex
xref: 9889196
controlled: Phosphorylation.I.CycA.Cdk2.CDC6

RBL2
type: Protein
entity reference: RBL2

MYBL2_DNA
type: DnaRegion
entity reference: MYBL2

RB Family.family
type: Protein
data source: Spike
member physical entity: RBL2
member physical entity: RBL1
member physical entity: RB1
xref: ELK:F.329908

APC/C-FZR1.complex
type: Complex
data source: Spike
name: Anaphase promoting complex / FZR1(CDH1) activator

MYC_DNA
type: DnaRegion
entity reference: MYC

CDKN2A
type: Protein
entity reference: CDKN2A

.Family.E2F1.3....PROMOTES.RAD51.
type: TemplateReactionRegulation
control type: ACTIVATION
data source: Spike
xref: 15467751
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.RAD51

12947101
type: PublicationXref
title: Cell cycle-dependent phosphorylation of the large subunit of replication factor C (RF-C) leads to its dissociation from the RF-C complex
id: 12947101
db: PubMed

.Family.E2F1.3....PROMOTES.DHFR.
type: TemplateReactionRegulation
control type: ACTIVATION
data source: Spike
xref: 11491305
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.DHFR

TAU:F.000001
type: UnificationXref
id: TAU:F-000001
db: Spike DB

.PCNA.UNKNOWN.Complex.CAF.1...(CHAF1A).
type: Catalysis
control type: ACTIVATION_UNKMECH
data source: Spike
controller: PCNA
xref: 10648606
controlled: Physical.Interaction.U.PCNA.CAF.1

POLA1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5422

TAU:F.000006
type: UnificationXref
id: TAU:F-000006
db: Spike DB

10646863
type: PublicationXref
title: ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression
id: 10646863
db: PubMed

19285992
type: PublicationXref
title: Mechanism of ATP-driven PCNA clamp loading by S. cerevisiae RFC
id: 19285992
db: PubMed

PCNA
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5111

15380092
type: PublicationXref
title: Regulation of early events in chromosome replication
id: 15380092
db: PubMed

11340163
type: PublicationXref
title: A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression
id: 11340163
db: PubMed

.Family.E2F1.3....PROMOTES.RB1.
type: TemplateReactionRegulation
control type: ACTIVATION
data source: Spike
xref: 11491305
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.RB1

.Family.E2F1.3....PROMOTES.CDC6.
type: TemplateReactionRegulation
control type: ACTIVATION
data source: Spike
xref: 9774682
xref: 9778043
xref: 9520412
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.CDC6

CDKN1A
type: Protein
entity reference: CDKN1A

BTG2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7832

Translation
type: MolecularInteraction
participant: CDK1
participant: CDK1_RNA

CCNE1_DNA
type: DnaRegion
entity reference: CCNE1

.Complex.APC/C.CDC20....INHIBITS.GMNN.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: APC/C-CDC20.complex
xref: 15380092
controlled: Ubiquitination.I.APC/C.CDC20.GMNN

CCND1_RNA
type: RnaRegion
entity reference: CCND1

CDC25A_DNA
type: DnaRegion
entity reference: CDC25A

BTG2
type: Protein
entity reference: BTG2

CDC25A
type: Protein
entity reference: CDC25A

14530260
type: PublicationXref
title: Replication factor C clamp loader subunit arrangement within the circular pentamer and its attachment points to proliferating cell nuclear antigen
id: 14530260
db: PubMed

RAD51
type: Protein
entity reference: RAD51

RB1
type: Protein
entity reference: RB1

.Family.E2F1.3....PROMOTES.TK1.
type: TemplateReactionRegulation
control type: ACTIVATION
data source: Spike
xref: 11491305
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.TK1

.TP53.PROMOTES.BTG2.
type: TemplateReactionRegulation
control type: ACTIVATION
data source: Spike
xref: 8944033
xref: 10669755
controller: TP53
controlled: Transcription.Regulation.P.TP53.BTG2

Homo sapiens
type: BioSource
xref: 9606

9778043
type: PublicationXref
title: Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F
id: 9778043
db: PubMed

BLM
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#641

CCNB1_RNA
type: RnaRegion
entity reference: CCNB1

E2F1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1869

.Family.E2F1.3....PROMOTES.MYBL2.
type: TemplateReactionRegulation
control type: ACTIVATION
data source: Spike
xref: 15510213
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.MYBL2

UHRF1_DNA
type: DnaRegion
entity reference: UHRF1

17912037
type: PublicationXref
title: E2F-dependent induction of p14ARF during cell cycle re-entry in human T cells
id: 17912037
db: PubMed

MCM.complex
type: Complex
component: MCM10
component: MCM5
component: MCM6
data source: Spike
name: minichromosome maintenance complex

10648606
type: PublicationXref
title: A CAF-1-PCNA-mediated chromatin assembly pathway triggered by sensing DNA damage
id: 10648606
db: PubMed

9606
type: UnificationXref
id: 9606
db: taxonomy

MCM5
type: Protein
entity reference: MCM5

.Family.E2F1.3....PROMOTES.MCM5.
type: TemplateReactionRegulation
control type: ACTIVATION
data source: Spike
xref: 8348613
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.MCM5

.Family.E2F1.3....PROMOTES.E2F1.
type: TemplateReactionRegulation
control type: ACTIVATION
data source: Spike
xref: 11491305
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.E2F1

CCNB1_DNA
type: DnaRegion
entity reference: CCNB1

http://www.ncbi.nlm.nih.gov/#1017
type: UnificationXref
id: 1017
db: Entrez Gene

Translation
type: MolecularInteraction
participant: MCM5
participant: MCM5_RNA

.MYBL2.PROMOTES.CDK1.
type: TemplateReactionRegulation
control type: ACTIVATION
data source: Spike
xref: 15510213
controller: MYBL2
controlled: Transcription.Regulation.P.MYBL2.CDK1

http://www.ncbi.nlm.nih.gov/#5810
type: UnificationXref
id: 5810
db: Entrez Gene

CEN:F.329953
type: UnificationXref
id: CEN:F-329953
db: Spike DB

http://www.ncbi.nlm.nih.gov/#1019
type: UnificationXref
id: 1019
db: Entrez Gene

CDK4_DNA
type: DnaRegion
entity reference: CDK4

12530060
type: PublicationXref
title: Overexpression of ICBP90, a novel CCAAT-binding protein, overcomes cell contact inhibition by forcing topoisomerase II alpha expression
id: 12530060
db: PubMed

http://www.ncbi.nlm.nih.gov/#3364
type: UnificationXref
id: 3364
db: Entrez Gene

UHRF1
type: Protein
entity reference: UHRF1

RAD1
type: Protein
entity reference: RAD1

CDC6
type: Protein
entity reference: CDC6

CCND1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#595

CycD-Cdk4.complex
type: Complex
component: CycD.family
component: CDK4
data source: Spike
name: CyclinD-CDK4

E2F1-3.family
type: Protein
data source: Spike
xref: TAU:F.000001

UHRF1_RNA
type: RnaRegion
entity reference: UHRF1

CCNB2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#9133

.Family.E2F1.3....PROMOTES.CDK1.
type: TemplateReactionRegulation
control type: ACTIVATION
data source: Spike
xref: 11491305
xref: 15510213
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.CDK1

MCM10_DNA
type: DnaRegion
entity reference: MCM10

http://www.ncbi.nlm.nih.gov/#1026
type: UnificationXref
id: 1026
db: Entrez Gene

Translation
type: MolecularInteraction
participant: MLH1_RNA
participant: MLH1

MCM6
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4175

http://www.ncbi.nlm.nih.gov/#1029
type: UnificationXref
id: 1029
db: Entrez Gene

CCND3
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#896

.Family.E2F1.3....PROMOTES.CDKN2A.
type: TemplateReactionRegulation
control type: ACTIVATION
data source: Spike
xref: 11491305
xref: 17912037
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.CDKN2A

CDK2
type: Protein
entity reference: CDK2

MYBL2
type: Protein
entity reference: MYBL2

CDKN2A_RNA
type: RnaRegion
entity reference: CDKN2A

Translation
type: MolecularInteraction
participant: DHFR_RNA
participant: DHFR

http://www.ncbi.nlm.nih.gov/#1719
type: UnificationXref
id: 1719
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#4609
type: UnificationXref
id: 4609
db: Entrez Gene

CycE-Cdk2.complex_inactive
type: Protein

.MYC.PROMOTES.CDC25A.
type: TemplateReactionRegulation
control type: ACTIVATION
data source: Spike
xref: 11602341
controller: MYC
controlled: Transcription.Regulation.P.MYC.CDC25A

MCM5_DNA
type: DnaRegion
entity reference: MCM5

CycA-Cdk2.complex
type: Complex
component: CDK2
data source: Spike
name: CycA-Cdk2

http://www.ncbi.nlm.nih.gov/#4605
type: UnificationXref
id: 4605
db: Entrez Gene

CDK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#983

CycD.family
type: Protein
data source: Spike
member physical entity: CCND3
member physical entity: CCND1
member physical entity: CCND2
xref: TAU:F.000006

.Complex.RFC..RFC1..PROMOTES.PCNA.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: RFC.complex
xref: 14530260
controlled: Physical.Interaction.P.RFC.PCNA

.MCM10.PROMOTES.POLA1.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: MCM10
xref: 15494305
controlled: Physical.Interaction.P.MCM10.POLA1

CDC25A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#993

.Family.E2F1.3....PROMOTES.CCND1.
type: TemplateReactionRegulation
control type: ACTIVATION
data source: Spike
xref: 11491305
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.CCND1

http://www.ncbi.nlm.nih.gov/#641
type: UnificationXref
id: 641
db: Entrez Gene

PCNA_DNA
type: DnaRegion
entity reference: PCNA

.Complex.APC/C.FZR1....INHIBITS.CDC6.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: APC/C-FZR1.complex
xref: 15678131
controlled: Ubiquitination.I.APC/C.FZR1.CDC6

.Family.E2F1.3....PROMOTES.CCNE1.
type: TemplateReactionRegulation
control type: ACTIVATION
data source: Spike
xref: 11491305
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.CCNE1

Translation
type: MolecularInteraction
participant: CDKN2A
participant: CDKN2A_RNA

Translation
type: MolecularInteraction
participant: CCNB1_RNA
participant: CCNB1

http://www.ncbi.nlm.nih.gov/#5981
type: UnificationXref
id: 5981
db: Entrez Gene

11077446
type: PublicationXref
title: PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition
id: 11077446
db: PubMed

CCNB2
type: Protein
entity reference: CCNB2

.PCNA.PROMOTES.RFC1.
type: Catalysis
control type: ACTIVATION
data source: Spike
controller: PCNA
xref: 19285992
controlled: Physical.Interaction.P.PCNA.RFC1

9774682
type: PublicationXref
title: Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F
id: 9774682
db: PubMed

CCND1_DNA
type: DnaRegion
entity reference: CCND1

CycD-Cdk4.complex_inactive
type: Protein

TK1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7083

20686481
type: PublicationXref
title: Rb regulates fate choice and lineage commitment in vivo
id: 20686481
db: PubMed

.Family.E2F1.3....PROMOTES.MCM6.
type: TemplateReactionRegulation
control type: ACTIVATION
data source: Spike
xref: 8348613
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.MCM6

Translation
type: MolecularInteraction
participant: UHRF1_RNA
participant: UHRF1

RAD1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5810

http://www.ncbi.nlm.nih.gov/#7528
type: UnificationXref
id: 7528
db: Entrez Gene

.Complex.CycA.Cdk2..CDK2..INHIBITS.Complex.APC/C.FZR1...(CDC23).
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CycA-Cdk2.complex
xref: 11340163
controlled: Phosphorylation.I.CycA.Cdk2.APC/C.FZR1

GMNN
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#51053

ORC.complex
type: Complex
data source: Spike
name: Origion Recognition Complex

MYBL2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4605

http://www.ncbi.nlm.nih.gov/#55388
type: UnificationXref
id: 55388
db: Entrez Gene

TP53
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7157

http://www.ncbi.nlm.nih.gov/#5422
type: UnificationXref
id: 5422
db: Entrez Gene

E2F1
type: Protein
entity reference: E2F1

RAD51_RNA
type: RnaRegion
entity reference: RAD51

CycB-Cdc2.complex
type: Complex
component: CDK1
component: CycB.family
data source: Spike
name: CyclinB-Cdc2 (CDK1)- M-phase-promoting factor (MPF)

CDK4
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1019

CDK4
type: Protein
entity reference: CDK4

Translation
type: MolecularInteraction
participant: CCNE1_RNA
participant: CCNE1

http://www.ncbi.nlm.nih.gov/#4175
type: UnificationXref
id: 4175
db: Entrez Gene

RB1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5925

http://www.ncbi.nlm.nih.gov/#4174
type: UnificationXref
id: 4174
db: Entrez Gene

PCNA
type: Protein
entity reference: PCNA

.BTG2.INHIBITS.CCND1.
type: Catalysis
control type: INHIBITION
data source: Spike
controller: BTG2
xref: 10669755
controlled: Other.I.BTG2.CCND1

CCND3
type: Protein
entity reference: CCND3

http://www.ncbi.nlm.nih.gov/#595
type: UnificationXref
id: 595
db: Entrez Gene

TOP2A_DNA
type: DnaRegion
entity reference: TOP2A

APC/C-CDC20.complex
type: Complex
data source: Spike
name: Activated APC/C (complexed with the cdc20 activator)

http://www.ncbi.nlm.nih.gov/#990
type: UnificationXref
id: 990
db: Entrez Gene

15459661
type: PublicationXref
title: Connecting proliferation and apoptosis in development and disease
id: 15459661
db: PubMed

TOP2A
type: Protein
entity reference: TOP2A

Spike
type: Provenance

http://www.ncbi.nlm.nih.gov/#29128
type: UnificationXref
id: 29128
db: Entrez Gene

.Family.E2F1.3....PROMOTES.PCNA.
type: TemplateReactionRegulation
control type: ACTIVATION
data source: Spike
xref: 11491305
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.PCNA

Translation
type: MolecularInteraction
participant: MYC
participant: MYC_RNA

10669755
type: PublicationXref
title: Arrest of G(1)-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcription
id: 10669755
db: PubMed

UHRF1
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#29128

http://www.ncbi.nlm.nih.gov/#993
type: UnificationXref
id: 993
db: Entrez Gene

Translation
type: MolecularInteraction
participant: CDK4_RNA
participant: CDK4

.Family.E2F1.3....PROMOTES.CDC25A.
type: TemplateReactionRegulation
control type: ACTIVATION
data source: Spike
xref: 11491305
controller: E2F1-3.family
controlled: Transcription.Regulation.P.E2F1.3.CDC25A

.RB1.INHIBITS.Family.E2F1.3....
type: Catalysis
control type: INHIBITION
data source: Spike
controller: RB1
xref: 20686481
controlled: Physical.Interaction.I.RB1.E2F1.3

RAD51
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#5888

CDK1_DNA
type: DnaRegion
entity reference: CDK1

CDK2
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#1017

Translation
type: MolecularInteraction
participant: MCM6_RNA
participant: MCM6

ELK:F.329908
type: UnificationXref
id: ELK:F-329908
db: Spike DB

RB1_inactive
type: Protein
entity reference: RB1

MCM6
type: Protein
entity reference: MCM6

RB1_RNA
type: RnaRegion
entity reference: RB1

CDKN2A_DNA
type: DnaRegion
entity reference: CDKN2A

http://www.ncbi.nlm.nih.gov/#5883
type: UnificationXref
id: 5883
db: Entrez Gene

MCM10
type: Protein
entity reference: MCM10

TK1_DNA
type: DnaRegion
entity reference: TK1

TK1
type: Protein
entity reference: TK1

YY1
type: Protein
entity reference: YY1

CycE-Cdk2.complex
type: Complex
component: CDK2
component: CCNE1
data source: Spike
name: Cyclin E - CDK2

MCM10
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#55388

http://www.ncbi.nlm.nih.gov/#983
type: UnificationXref
id: 983
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#5888
type: UnificationXref
id: 5888
db: Entrez Gene

Translation
type: MolecularInteraction
participant: MYBL2
participant: MYBL2_RNA

TOP2A
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#7153

TOP2A_RNA
type: RnaRegion
entity reference: TOP2A

911-complex.complex
type: Complex
component: HUS1
component: RAD9A
component: RAD1
data source: Spike
name: 911

15143166
type: PublicationXref
title: Physical and functional interaction between the Bloom's syndrome gene product and the largest subunit of chromatin assembly factor 1
id: 15143166
db: PubMed

.YY1.UNKNOWN.RB1.
type: Catalysis
control type: ACTIVATION_UNKMECH
data source: Spike
controller: YY1
xref: 11118439
controlled: Physical.Interaction.U.YY1.RB1

http://www.ncbi.nlm.nih.gov/#4292
type: UnificationXref
id: 4292
db: Entrez Gene

CCND2
type: Protein
entity reference: CCND2

CAF-1.complex
type: Complex
data source: Spike
name: chromatin assembly factor 1

MCM5
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4174

pre_RC.complex
type: Complex
component: MCM10
component: CDC6
component: MCM5
component: MCM6
data source: Spike
name: pre_Replication Complex

http://www.ncbi.nlm.nih.gov/#5925
type: UnificationXref
id: 5925
db: Entrez Gene

15494305
type: PublicationXref
title: Mcm10 regulates the stability and chromatin association of DNA polymerase-alpha
id: 15494305
db: PubMed

GMNN_inactive
type: Protein
entity reference: GMNN

RAD9A
type: Protein
entity reference: RAD9A

.MYC.PROMOTES.CDK4.
type: TemplateReactionRegulation
control type: ACTIVATION
data source: Spike
xref: 17093053
xref: 11602341
controller: MYC
controlled: Transcription.Regulation.P.MYC.CDK4

.GMNN.INHIBITS.Complex.pre RC..CDC6,.MCM5,.MCM6,.MCM10.(CDC6).
type: Catalysis
control type: INHIBITION
data source: Spike
controller: GMNN
xref: 15380092
controlled: Physical.Interaction.I.GMNN.pre RC

CycB.family
type: Protein
data source: Spike
member physical entity: CCNB1
member physical entity: CCNB2
xref: CEN:F.329953

MLH1_RNA
type: RnaRegion
entity reference: MLH1

.Complex.CycB.Cdc2..CDK1,.Family.CycB..CCNB1,.CCNB2...INHIBITS.Complex.RFC..RFC1.(RFC1).
type: Catalysis
control type: INHIBITION
data source: Spike
controller: CycB-Cdc2.complex
xref: 12947101
controlled: Phosphorylation.I.CycB.Cdc2.RFC

11602341
type: PublicationXref
title: Function and regulation of the transcription factors of the Myc/Max/Mad network
id: 11602341
db: PubMed

CDC6_DNA
type: DnaRegion
entity reference: CDC6

15361834
type: PublicationXref
title: ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain
id: 15361834
db: PubMed

http://www.ncbi.nlm.nih.gov/#5933
type: UnificationXref
id: 5933
db: Entrez Gene

http://www.ncbi.nlm.nih.gov/#5934
type: UnificationXref
id: 5934
db: Entrez Gene

MYC
type: ProteinReference
organism: Homo sapiens
xref: http://www.ncbi.nlm.nih.gov/#4609