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Proteins

Proteins are organic molecules which are responsible for most chemical reactions performed in the cell, and thus, are essential for all cell functions. A protein is a polypeptide - a macromolecule composed of building blocks called amino acids attached end to end in a linear string. There are 20 amino acids, with an average protein chaining about 200 of these. Proteins have a complex structure, which can be thought of as having four logical levels. The amino acid sequence of a protein's chain is called its primary structure. Different regions of the sequence form local regular secondary structures, such as \( \alpha \)-helices which are single stranded helices of amino acids, and \( \beta \)-sheets which are planar patches woven from chain segments that are almost linearly arranged. The tertiary structure is formed by packing such structures into one or several domains. The final, complete, protein may contain several protein chains arranged in a quaternary structure.

  
Figure: protein structure [4]

\includegraphics{lec01_figs/figure6_small.ps}


The whole complex structure (primary to quaternary) is practically determined solely by the primary sequence of amino acids (and therefore, is defined by the genetic material itself). The three dimensional structure is generally the one with the minimal free energy.


next up previous
Next: The Protein Folding Problem Up: Genetic information Previous: The Gene Finding Problem
Peer Itsik
2000-11-13