The research in our lab mainly focuses on the development of computational tools for the analysis of genetic data; we are mostly interested in the development of tools that enable and facilitate genetic and epigenetic studies of common complex diseases, such as cancer, rheumatoid arthritis, or cardiovascular diseases. These studies shed important light on the biological mechanisms of these diseases, and they will pave the way to improved diagnosis and a personalize treatment based on an individual's genetics.

In more technical terms, we develop methods for the analysis of population genetics data (e.g., genome-wide association studies), epigenomics data (e.g., epigenome-wide association studies), and other omics data of populations. Our main motivation is the development of these methods in order to improve and facilitate studies of complex diseases. In our search for improved methodology we also consider general problems about the population. For example, we characterized methylation differences between men and women, we developed methods for the inference of ancestry from genomics data, we showed that ancestry is a key factor in choice of mates, we helped characterizing the history of the Jewish people based on population genetic data, and we explore the potential risks for privacy when DNA data is shared in public databases.

In addition, we collaborate with groups around the world in order to study specific diseases. Particularly, we have been working on genetic and epigenetic studies of Non-Hodgkin lymphoma, leukemia, age relaetd macular degeneration, rheumatoid arthritis, coronary artery disease, myocardial infarction (heart attack), and other cardiovascular measurements.

In the media

May, 2016 - Yedael Waldman, a joint post-doc between our lab and in Alon Keinan's Cornell lab, publishes a paper about the genetic history of Bene-Israel Indian Jews. Science Daily, The Times of India, Haaretz.

November, 2015 - Our paper on epigenetic differences between men and women was featured in Nature Reviews Genetics.

October, 2015 - Our PNAS paper finds that people choose their mates based on their genomes. NDTV, Daily Mail, Business Standard, Science Daily.

January, 2013 - Our Science paper came out in the first page of the printed version of Israeli newspaper Ha'haretz, two days before the national paralament elections... Ha'aretz paper version Ha'aretz first page

July, 2012 - Israeli business newspaper (The Marker): 40 under 40
The Marker paper version The Marker online version

June, 2012 - Genetic GPS
Wired Magazine, Haaretz Israeli News, Haaretz (Hebrew version), Times of Israel, London Jewish Chronicle, International Business Times (Italian)

May, 2011 - Profiles in Computer Science
Biomedical Computation Review

September, 2009 - From DNA Data to Disease Diagnosis
Frontier Economy, Spanish version

August, 2009 - Researchers Claim New Software Can Skirt Privacy Challenges of GWAS Data-Sharing
GenomeWeb, Innovation report, Physorg, , The Medical News (Sydney, Australia), Jerusalem Post, ynet (Israel), Biopharma.

July, 2009 - Gene linked to increasingly common type of blood cancer
EurekAlert

Funding and Acknowledgements

We thank The Edmond J. Safra Center for Bioinformatics for the continuing support of many of our students.
We also thank the Israeli Science Foundation, the German-Israeli Science Foundation, IBM, The National Science Foundation, and the National Institute of Health for their support in the past, present, and hopefully in the future.
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