Supplementary Material, Movie 3: A negative control experiment - Glycophorin A

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Glycophorin A is a bitopic TM protein that forms stable homodimers, and the NMR structure of this protein

shows that the two TM helices are packed together via Gly79 and Gly83. We carried out calculations using

the NMR structure as the initial conformation. The calculation, which can be thought of as a negative control

experiment, resulted in a redundant pathway presented above.