Supplementary Material, Movie 2: Ser656-xxx-Gly660 towards Gly668-xxx-Gly672

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To see the movie, press right bottom -> Animate -> Play

The movie presents the backward pathway that was ranked first according to the colony function.

The pathway starts from the less stable conformation involving the Ser656 and Gly660 residues towards

the stable conformation involving the Gly668 and Gly672 residues. The helices move subjected to the

ridges-into-groves packing and the stability at each step along the pathway is determined by the steric properties

of the residues that mediate the inter-helix contact.